LOCUS       gnlProkkaCCAEHOLC_28   13097 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CCAEHOLC_28.
ACCESSION   gnlProkkaCCAEHOLC_28
VERSION     gnlProkkaCCAEHOLC_28
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 08:51:54
            Original ID  :: gnl|Prokka|CCAEHOLC_28
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13097
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..132
                     /locus_tag="ctg28_1"
                     /transl_table=11
                     /translation="MDEERKQAVLTRSLSLLDVLPPSLLKQQLSAVCHGMQELCEIN"
     protocluster    1..13097
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3804:8097]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3805..8097
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13097
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13097
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             150..2561
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 32.3;
                     E-value: 7e-10)"
                     /gene_kind="transport"
                     /locus_tag="ctg28_2"
                     /sec_met_domain="Poly_export (E-value: 1.8e-18, bitscore:
                     56.9, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCLMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKNTSDMLED
                     HPTTQDLARGDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKNALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDIDYNIYKMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMDGT
                     SPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDISRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILEPYDQVYVRRSPG
                     YQAQQNVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKK
                     RMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIP
                     KNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKG
                     SGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             2572..3720
                     /locus_tag="ctg28_3"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             3805..4503
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_4"
                     /sec_met_domain="NTP_transf_3 (E-value: 5.1e-15, bitscore:
                     46.7, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLSCDIERIV
                     IGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLLESDLIFE
                     KQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKGELVGIHK
                     LSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEIDDISDLE
                     YAEKYIVPYC"
     CDS             4524..5825
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_5"
                     /sec_met_domain="CTP_transf_like (E-value: 3.4e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 3.5e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3.9e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             5842..6966
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_6"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.8e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.6e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             6976..8097
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg28_7_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_7"
                     /sec_met_domain="Aminotran_5 (E-value: 2.6e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        7066..8073
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg28_7_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg28_7_Aminotran_5.1"
                     /locus_tag="ctg28_7"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             8094..8237
                     /locus_tag="ctg28_8"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             8440..9924
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_9"
                     /sec_met_domain="Polysacc_synt (E-value: 2.3e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             9878..11137
                     /locus_tag="ctg28_10"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             11146..11895
                     /locus_tag="ctg28_11"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             11895..12935
                     /locus_tag="ctg28_12"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 gaagacgaag aaagaaaaca ggctgttttg acccgttctc tgtctcttct cgatgttctt
       61 cccccttctc ttcttaagca acagttatct gccgtctgtc atgggatgca ggaactgtgt
      121 gaaatcaact gaaacttttt tatttgtcaa tgaaaataca acgacttttt agcattctac
      181 tattttgttt gatgctggga agtggctcgc ttatggctca gtccatgagt gactcacagg
      241 tactggaata tgtaaaagac ggcatccgcc aaggcaagga acagaagcag cttgcttccg
      301 aactagcccg taagggtgta accaaagaac aggcaatgcg tgtgaagcag ctatacgagc
      361 agcagaacaa tgtaaatacc tcgaaatcaa cgggcacgga catcaacgaa tcccgcctgc
      421 gtgaagagac taagaagaat acttccgata tgctggagga tcatccgact actcaggacc
      481 ttgcccgtgg tgatcaggtc ttcggacgta acatcttcaa tacccgcaac ctgacgttcg
      541 agcctagtgt caaccttgcc actcctgcca attaccgtct tggtcccggt gatgaagtca
      601 tcattgatat ctggggtgcg agccagaaca cgatccgcca gcaaatctct cctgaaggta
      661 ctatcaacat tcagaagatc ggccctgtca accttagcgg tatgacagtc tctgccgcca
      721 atgactatct gaagaacgcc ctgaataaaa tatataacgg tctgaataat actaccgatc
      781 ctacttccga catccgtctg acgttaggta atatccgtac tattcagatt aatgtgatgg
      841 gagaagtcgt acagcccggt acctacgccc tttcttcctt ctctaccgtc ttccatgcgc
      901 tttatcgtgc aggcggtgtg agtgatatcg gtagcctccg aaacgttcag ttggtacgca
      961 acggaaagaa tattgccacc atcgacgtct acgaattcat tatgaaaggc aacacacagg
     1021 atgacatccg cctacaggaa ggtgacgttg tgattgttcc tgcctatgat gtattggtaa
     1081 agattagcgg caaggtaaaa cgtcctatgc gttttgaaat gaagaaagac gagaaccttg
     1141 ctactctcat taaatatgcc ggcggctttg aagctgatgc ctacacccgt tcattacgtg
     1201 ttgtccgtca gaatggtgag gaatacgaag tcaacacagt caaagatata gattacaaca
     1261 tttataaaat gcgtaacggt gacgtagtaa ccgccgaagc catccttaac cgcttcacaa
     1321 acaaactgga aatccgtggc gctgtctatc gtcccggtat ctaccagctc agcggtaaac
     1381 tgaacacgat ccgcgaactt gtccatgaag ctcagggtct gaccggtgac gctttcctga
     1441 atcgtgccgt cctctatcgc cagcgtgaag acctgaccag tgaagttgtt cagatagaca
     1501 ttaagtctat catggacggc acttccccaa accttgccct aatgaagaat gacatcctct
     1561 acattccaag tatccatgac ctggaagacc ggggtaatgt cacagttcac ggtgaggttg
     1621 cccaccctga ttcctatcct tatgcggata acatgacact tgaggatctg atcattcagg
     1681 ccggtggctt gaaagaagcc gcctctactg tccgtattga tatatcgaga cgaatcaaga
     1741 atcctcgtag tactgcggat aatgatacga ttggtcagat gtataccttc tctttaaagg
     1801 atggttttgt aatagatggt cagcccggtt ttatccttga gccttatgat caggtttatg
     1861 tccgtcgcag tccgggctat caggcacaac agaatgtagc cattgaaggt gaaatccttt
     1921 tcggaggaaa ttacgccatg accagccgtg aggaacgtct ttccgattta gtgaataaag
     1981 ccggcggtcc gaccaattat gcctatctgc gtggtgcgaa actgacccgt gtggctaacg
     2041 ctagtgaaaa gaaacgtatg ggtgatgtaa ttcgccttat gagcaggcaa ttgggcgaag
     2101 ccatgattga ctctttgggt attcgtgttg aagatacttt tacggttgga atagatttgg
     2161 aaaaagcctt gagcaatcct aaaagtaatg ccgatcttgt cttacgtgaa ggtgatgtga
     2221 tctccatacc taagaatact aatactgtaa ctatcaatgg tgctgtcatg gttccgaata
     2281 cggtttctta tatgaaggga aagaatgtgg attattacct gaatcaggcc ggtggctgtt
     2341 ctgataatgc aaggaagagt aagaagttca ttgtttacat gaatggtcag gtgacgaagg
     2401 ttaagggtag tggtaagaaa cagattgagc cggggtgtga gattattgtg cctggtaagg
     2461 ctaagaagaa agggaacata gctaatattt taggttatgc tacttccttc agttctttgg
     2521 gaatgatgat tgcttctatt gctaatttga taaagaaata aatgacctat tatgattgaa
     2581 aagcaatctt atcaagaacc gttttctgaa gtggataaaa ggaaagatga tgaaatggaa
     2641 atagacttga tggctatttt ttataagatt attactgttc gtggagtact atgcaaagct
     2701 gctggagtgg gagtaataat tgctatagtg gtggcattga gcattcccaa gcaatataca
     2761 gtaaaggtta ccctttctcc tgaaatgggt aatgcgaagg gaagtaatgg tttagccgga
     2821 cttgctgcct cgtttttggg agatggggct ctaatagggg aaagcacaga tgccttgaac
     2881 gcttctcttt cagcagatat tgtttcttca actccttttt tattggaact tttagaaatg
     2941 gaagtctccg tttctaaaaa ggatgataaa atgactttgg ggtcttatct cgatgaagag
     3001 tcatctcctt ggtgggatta tcttataggt tttccgggca tagtaatagg aggagttaaa
     3061 tcattattcg gagaagatac ggttcctgcc agtggagggc ggcaaggaac tatcgaattg
     3121 acgaaagaag taaatgagaa gattaatttt cttaaaaaga agattagtgc atccattgat
     3181 aagaaaaccg ccataacgag cattacggtc accttacaaa atccgcagat cactgcggtt
     3241 atagcagatt ctgtcgttca taaattacag gaatatatta ttgggtatcg aacttcaaaa
     3301 gtaaaagaag actgtgcgta tttggaacgg ttgtttaaag aacgtcagca ggaatattat
     3361 gctgctcaaa gaaaatatgc ggattatgta gacgcccatg ataatgtggt tcttcaaagt
     3421 gtacgtgctg agcaggagcg tttacagaac gacatgagtt tggcttatca gatatatagt
     3481 caggttgcta atcagttgca ggtatccaga gccaaagtac aggaggaaaa gccagtcttt
     3541 gcagtagttg agcctgccgt tgtacctttg aaaccttcag gtatgggact caaaatttat
     3601 attttattat ttgtgttcct gtccgtatct ggtactctcg tgtgggtgtt ttttggcaaa
     3661 agtctgctgg ctagcttgag aaaagaactg aaaaataagg agatagaaca ggataaatga
     3721 tgctaaaacg tcgtttacaa cattcttaca tcaattaaat tcacttacta tattattaaa
     3781 cgaatgatac gtacagctat gataatggct gcgggcatgg gaacccgttt tggccaatat
     3841 acagaattga tacctaaagg gttcgtcaaa gtgggaggta ttccaatgat agttcgttct
     3901 attgatactt tgttatcatg tgacattgag cgaattgtaa tcggtacagg atataaacaa
     3961 gaagtttatg aagaattgaa gacagactat cctatgcttg aaacctgttt tagtcctcgt
     4021 tatgctgaaa caaatagtat gtatacttta tataatacgc gggagattct gggcaatgat
     4081 gattttttat tgttagagtc agatttgatt tttgagaaac aagcaataat gagcttattg
     4141 gagtgtcctg cggcagatgc aatgctaata actccagtga caaagtttca agatcagtat
     4201 tatgtggaac atgatgataa ttttcgcctt tcttcatgtt ctgtcaataa gaataaacta
     4261 aacgctaaag gcgaattggt cggcatccat aaactatccg gttcctttta caaaataatg
     4321 tgtgctgatt atgcgagtat tgttgatgaa caacccaatt tgggatatga gtatgaatta
     4381 ctacgaatat cttgttctca atctcctgtt tatgtgcata aagtagaagg gctgaaatgg
     4441 tatgaaatcg atgacatatc agatttggaa tatgcagaga aatatattgt tccgtattgt
     4501 taattaaaat aatatatcaa attatgagta agacagttta tattgggatg actgcggata
     4561 ttatgcatcc aggacttatc cgcattatta atgaggctac taaatacggt gatgttataa
     4621 ttggtcttct tacagataaa gctattgcgg agcataaacg ccttccttat ctgacctatg
     4681 aacaacgaaa agaggtagtt cagaatatta aaggcgtatg taaagttgtt cctcaagaag
     4741 aatggagcta tgttgagaat ctcaaacgca ttaaacctga ctatataatt catggtgacg
     4801 actggaaaac cgggccttta cgtgaagaac gtgtgcgcgt atttgaagtg atgaatgaac
     4861 agggaggaaa ggttatcgaa attccatata ctttgggaat taattcatct tctttggata
     4921 aagatattaa ggctataggt acaacccctg atgtacgttt aaaatcactt cgtcgtttga
     4981 taaatgccaa acccgtagtt cgtattttgg aagctcatga tggactatgt ggcttgataa
     5041 ttgaaaatca ggaaatatta aaaggggata agagggaagt atttgacgga atgtggtcta
     5101 gtagccttac ggattcaacc agtaaaggta aacctgatat tgaggcggtt gatttaacta
     5161 cccgattgca agatttgaat aatattctgg agtgtactac taaacctatt atttttgatg
     5221 gagatacagg tggtaaaatt gaacatttcg tatttacagt acgcacttta gaacgtcatg
     5281 gaatttcagc tataataatt gaagataaag ttggattaaa aaagaattca ttgtttggta
     5341 cagatgttat tcaaactcaa gatacaatcg aaggtttctg taataagatc aaagcaggaa
     5401 aggcatctca gattactgat gattttatga ttatcgctcg tattgagagc cttatagcgg
     5461 gaaagccggt aagtgatgct ttagagagag cttttgcata tgtccaagcg ggagcggacg
     5521 gtattatgat acatagcaaa aataagtcgg gtgaagatat aaaagaattt tgtttggcgt
     5581 ttcgaaaaca gtatgctcat gtacctatcg tggttgtgcc tactacatat gatcatattt
     5641 atgagtctga attgtgtgat tggggtgtga atataattat ttatgctaat catatgcttc
     5701 gtgccgctta tcctgctatg atgaatgtcg caaagataat attagagaat gaacgtgctt
     5761 tagaggtgcg cgaactgtgt atgcccataa aagaaatatt ggaactgatt ccaggtacta
     5821 aataaaaaga ggaatatcat tatgttaagc gtagaaaaag tttatgaaac gtttctgagt
     5881 catgacgttg atttttttac aggagttcca gactcattac taaaaaatat ttgtgcctat
     5941 atcacagacc atacttcacg tgagaaacat atcatagctg ctaatgaagg tgcggctgta
     6001 ggaattgctt caggttatta tatggcatca ggtaaggttc ctgtggttta tatgcaaaat
     6061 tccggcttgg gtaatactgt taatcctctg ctgtctcttg cagatgaaca agtatacagt
     6121 tttccaatgc ttttgatgat tggctggcgt ggtgaaccgg gaacaaaaga tgaacctcag
     6181 cataaaaaac agggtgaggt aactttagat ttgttgaaag caatgcggat tccttatata
     6241 attcttgatt caaatgagaa tgatgcattt attcagctcc atgatatcat acaatcagca
     6301 aaaactaaga atattcctca tgcaataatt attcggaaag atgtttttgg caaatataaa
     6361 cttcaaaaag agttcggatg taattatcct ttatctcgtg aggatgcttt gcaaatagtt
     6421 gtggattatc tgcctgaaaa ttcagtggtc gtttctacta ctggcaagct ttctcgtgag
     6481 ttatttgaat atcgagaaat gaaagagcaa ggtcatgaac atgattttct cacggtaggc
     6541 tctatgggac atagttcatc aatctctttg ggtattgcta tagcaaagca agatagacct
     6601 gtttattgct tggatggtga tggagcattt attatgcatt taggggcaat tagtaacatt
     6661 ggcgatttat ctcctaaaaa ctattatcat attttgttta acaatggtgc tcacgagtct
     6721 gtaggaggac agcctacttt aggatttagt ttagatattc cggctattgt ccgggggagc
     6781 ggatataagc atacttatac tgtttgtaca aaagttgaaa ttgaagaagc aatgaagcag
     6841 cttccaaagt tatgtggtcc tgttttgttg gaaataaagg ttaaaataga ttctcgggag
     6901 aatttgggac gtcccacgac tactcctata gagaataagg agcattttat ggatttttta
     6961 aaataaatat attcgatgaa aatagaaaga aaaatattat taaatcctgg gcctgccact
     7021 actactgaca gtgtaaaaat ggcacaagtt gttccggata tttgtcctcg cgagaaagaa
     7081 ttcgcaggta tgatgaaaca acttcgggac gatttggtca gagttgctca tgggaatttg
     7141 gaaaaacata ccgctgtatt attttgtggc tcaggaacca tcaatattga tatatgtcta
     7201 aattctcttc ttcctgaaga caaaagggtg cttatagtga ataatggggc atatagtacc
     7261 cgtgctgtag aagtgtgtca atattatggt ttgcctcata ttaatttgga attttccgtt
     7321 tacgaacgtc ctgatttatc ggtggtggaa aatgtgttgc aagaaaatcc tgatatagct
     7381 atggtttata ctactcatca cgagacgggt acaggaattc tgaaccctat tcgcgagatg
     7441 ggcgctatag ctcataaata tcaggctaaa tttgtcgtcg atactacttc ttctttgggc
     7501 atgattcctt ttgatataga gaaagataat gtggattttt gtatggcatc tgctcaaaaa
     7561 ggacttcaag cgatgacagg tctttctttt attataggca atgaggaaca gattaagttt
     7621 tcaaaaaaat atcccaagcg ttcttactat tgtaatcttt atttgcagta tgagaatttt
     7681 gagagaacag gtgaaatgca ttttactcca ccggtacaaa ctatttacgc cactcgtcag
     7741 gcattaaatg aatattttga agtgggtgaa gaagctaagt ttgcccgtca caaaagagtt
     7801 tttgaggcta ttcattcagg tataaatgaa attggtctta aaagtgtaat aaagcgtgaa
     7861 tggcagtcag gactggttgt ctcagttcaa tacccagaag atcccaactg ggattttgag
     7921 aaaatacatg attattgtta tgagcgtgga tttacgattt atccaggtaa gatatcaact
     7981 gaggatactt ttagaatctg tgctttagga gagatagaag tagatgatat tgagaacttc
     8041 tttaaagtac taaaagctgc attaaatcat tataacgtca cattaccgat gtcatgattg
     8101 cagaaatatt attgaagatt cgtcattttt atttttccct tcgtggtata cacttccatc
     8161 cggaaagtgt tatttctgga gtgcctattc gtagctttcg cttagtaggc aaatatggca
     8221 atattaattt gaggtgatgc attaggagtt ctttattctt ataaaaaggc atcggtagtt
     8281 ataggagata atgtttgtgt agggtaattt gcttttagtg ggagagacca tattagaatt
     8341 gcggtaaggg gcgaagaaga taataaccaa ttagtgagaa tattggaaaa atataattga
     8401 tatcggtaaa tgtagttgtt tttatactgt atttaagtaa tggaaaatct aaagcagaaa
     8461 actgtatcag gaataatgtg gagcgctata gaacgtttct ctttacaagg agtacagttt
     8521 ataattcaaa taatattagc tcgtttgtta ctaccatcgg attatggtat gatcgggatg
     8581 ttagctattt ttcttcaagt cgctcaagta tttatagata gcggttttac aaatgcttta
     8641 atccagaaaa aagatagaac tgaagaggat tttgccactg tcttttattt taatattctt
     8701 gtcgcagtat tattctatgg tatattgttt ttttcggctt ctttgattgc agacttttat
     8761 aatatgccga ctttagttct tgtaattcgt tttatagcat tgtcgttgat aataaatgct
     8821 ttatcggcta ttcacagaac gaaattaatt atttctgtaa actttaaaac tcaatctaaa
     8881 atttcattag gtgcagcttt tatatcaggc gtgattggaa tatggatggc ttatgtcggt
     8941 tgcggggttt gggctttagt ttggcaaact ctcttaaata gtataatttt gacaattttg
     9001 ttttactgtt tagttcattg gaaaccttta catactttct ccaaaagttc ttttgaaaga
     9061 ttattcaatt tcggatctaa attattgatc tcaagtctta tcaatacagt atatcgtaat
     9121 ctgtatacca ttgtaatagg aaaaaagttt tctgttgtag agcttggtta ctatacaaga
     9181 gcagaacaat ttgctatttt tccttccaat aatttaaatg ctttagtttc tagagtagcg
     9241 tatcctattt taagttccat tcaagatgat gataaatgtt taacaaacgc atatcgaaat
     9301 tatatcagat tatcctcata tataattttt cctttaatgg taggtttact tgttttggct
     9361 aatcctatta ttagtctatt gttaacagat aaatggtctg gggttgttat tcttttacag
     9421 atattatgtt tggattggat gtttgatcat ttgagccaaa ttaatttgaa tttattatgg
     9481 gttaaaggaa gatctgatct gtcgttacgt cttgaaataa taaaaaagac gattgctata
     9541 ttcattcttt ttgtgtcaat tccatttggg cttgaggtga tgtgttgggg tagagttatt
     9601 tactctctga tagcgacata tttgaataca tattatacta attctcttat tgatttgacc
     9661 ttaaagttgc aagttaaaga tgtatttcca agtttaatac tctctttcat aatggggggg
     9721 atcgttttta tatgtatttc tttctttgaa actgatatag taaaaattgt gattggatgt
     9781 attactggga tgtccttcta tattttactt tcttttcttt ttaagctaga ttcttttttt
     9841 tgtattttaa cattgatcat taaaactaaa aacatagatg aaaatattaa aaaagatttt
     9901 tcaagtaata gtaaagataa ttaaccattg tgtgccagtt gatagtagat cattgtattt
     9961 tattcctcat cctaattgta gaacagataa atatgatatt ataaattatt cgtcagataa
    10021 tgttctcgtt ctgttaaatt atttgctaaa aaaagatagt gctgaatatt ataaaatata
    10081 tgttgaaatt tatgattctt ctcgtatttc agaatatcaa gaatatattt atggcataaa
    10141 tcctaatatt aggtgtactt ttttatgtgc atgtgttgga cgttttttct ttaataaagt
    10201 atcttttaag gatatgttgt atgccttttt ttgtttttgt agagcaagta aatgttttac
    10261 agctactttt tattatgatt tttcatttaa aaaacgctct caacagatta tttgtttggg
    10321 gtattatact ccattcaaag atgattatca tatgggagat cattcttatg ataaatttcg
    10381 taatacaaca tgtaactcat ttgattactc tattgctact tcttgtttaa gtgctagaat
    10441 aatttcaata gattgtggaa tctcatatga taaattcaaa gtcttaggat ttcccagaaa
    10501 tgatttgttg atatcgaaaa ataattgcaa tgttattaaa agagaaattt cgaaatttgc
    10561 gggatatgat gtaactaaat atatagttta tactccaact tttcgtgatt atgagactgt
    10621 tactgaaggt aatttgcgtt caatactcgg atatgttgat tgtgatttgt tgaagttatc
    10681 gaaaatacta ttgaagttta atgcggcttt aattcttaaa ttacatcctt tgcagaataa
    10741 aacagtctta aaaaaagatt tacccaaagg tatacttgtt tttgaacaaa catataaata
    10801 tggattgtat gatcttttgt cattttcaga tggaatgatt actgattata cttctaccta
    10861 ttttgatttt ttattggtaa ataagccagt catatttaat ttctacgata ttgaagaata
    10921 tcgtagagta agaggtttct catttgagcc aatagaattt ttttgtgcag gtgatattgt
    10981 ttacaattat aatgaattga tagatgctgt gatgggactt ctggctggga aagatattca
    11041 tgctgaacat cgacgtcata tttctttatt gatgaatcaa tttcaagatg ataattcaac
    11101 aaagagaata tgtgacatat ttttaaatga aatataataa ataaaatgaa ttatgcattt
    11161 gtggtgcagg cacgtttagg ttctacacgt ttgcctggaa aaatattgaa acctttctat
    11221 ggtaatcaat cgattcttga cttaatggtt cataagcttt ctgctatatc gaatattcca
    11281 gtaattattg ctacaacaaa ttctgttatc aatgaaccta ttgaaaagaa ggcacttgca
    11341 ttaggggtaa agtgcttcag aggtgaggag aatgatgttt taaaacgatt cattgatgtt
    11401 gctgaatatt ttgatataca gggtatattc cgaatatgtt ctgataatcc atttttagat
    11461 gtacatgcgg caaggcaatt ggtcgaaata gcaatgaaat cttgtaacga ttatataagt
    11521 tttgatattg atggtactcc atcaattaaa actcatttcg gtttttgggg agaatttgta
    11581 acgcttgatg cgctgaagcg agttatagga tttactgatg atttattgta tcgtgaacat
    11641 gttactaatt atatatatag tcatcctgaa ctttttaata ttcaatggat ttcaggatct
    11701 ccagtcgtgt caaaacatca taatattcga ctcacgattg atacgttaga agatttttct
    11761 gtagcacaga gaatatatag ggatttacaa gaaaaaagag tggaaatatc gatagaagtg
    11821 attgtagact atgttcgaag acatgcagaa tacattcaac tgatgaaaca acaaataaaa
    11881 aaaaattcta aataatgaag aatacttata ttattggtga aatagggcag aatcataatg
    11941 gttctgttga cttggctaag ttgattattg aattaatctc acgacctgta catgaggatg
    12001 tttttggtat ggatttcatg ccaatgaatg ctgttaaaat gactaaaaga gatttatcag
    12061 aagaattggc tgtttctcaa atgaatcaaa tatatgacaa tcctaattct tttgggcgta
    12121 cttatggtga acatcgtgct tttcttgagc ttgatgatca agcgcatttt gagatttata
    12181 aatatgctaa gtcattagga ttagatttta tcgagacgtt atgtgccaaa ggatgtctgt
    12241 ctttgcttaa actgttcaca ccggataggc taaaagttgc tagtcgtgat ttgactaact
    12301 taccattgct tgaagcatta gcagaaactc atattcctat tatattatcg acaggaatgg
    12361 ctggtcaaag agaacttgac aatgcattag atgtgataac gagatatcat agtaatatag
    12421 ctattctaca ttgtgtatct cagtatccaa ctcatccaaa taatttgaat ctacgtacaa
    12481 taacatattt gaagaagcat tacaataagt ttgagatagg tttttctgat catacaatag
    12541 gtatttctgc tgctacagct gctgtagcga tgggagcgga aattatagaa aagcatgtaa
    12601 caattgatcg gcatatgaaa ggaacagacc agcttggctc tttaggtcca gatggggtta
    12661 atcgtatgat tcgagatatt cgcatagcag agtgttggct tggtactgaa gatctttata
    12721 tagaaaaagg ggtggagaag tctaagataa aacttgaacg ttctattgcc actcgaaaat
    12781 atattccagc aggtagtatt attcaagagt cggacattca tttactgagt cctggtgatg
    12841 gttataaatg gatagataaa aaaaatgtaa ttggtcattt tgctaaacaa gatatatcag
    12901 cgaatgaaat aatatatcct gattttattg aatagatata ttcctactgc aacttgtatt
    12961 acggtataga gtactgcctg ctataagcta agtagtgatt aataaataag ggtaaaatac
    13021 taaaaaaatg aaagagataa agcttatact tacagatatt gatggcgttt ggactgatgg
    13081 cggaatgttt tatgatc
//
