LOCUS       c00043_gnlPro..        16510 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OMKEBPEO_43.
ACCESSION   c00043_gnlPro..
VERSION     c00043_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 05:15:50
            Original ID  :: gnl|Prokka|OMKEBPEO_43
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16510
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16510
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3041:6599](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3042..6599
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16510
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16510
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(469..1623)
                     /locus_tag="ctg43_1"
                     /transl_table=11
                     /translation="MALASGETNYMAPASARQMASDLALLPMWYAEAGSAVLAPSAYNA
                     DFLKTKSELLGMDVALLTEPEVADGKDWKFSPWGWDPALRKRLMTLGAGQTELPSADYM
                     NILREHSHRLQAVKLLPGLRLNEYFCGESFYLSTLAECSAFVEGREACLLKAPLSGSGK
                     GLNWCKGIFTTFISGWCARVAASQGGVVGEPIYNKVEDFAMEFYADGRGRVVFAGYSVF
                     HTGGSGMYAGNDLLSDEKILQKLSAYVPQEEFIRLRTRLEEELSALFGGFYHGYLGVDM
                     MICHFPDEAPVYRIHPCVEINLRMNMGVVAWLLTDRYLAADAEGVFRIDYYPLAGQALE
                     EHRQMSASFPLSVENNRVCAGYLPLVPVTPQSRYRAFLLLTLPQ"
     CDS             1803..3008
                     /locus_tag="ctg43_2"
                     /transl_table=11
                     /translation="LPAEKQRNEMESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGI
                     KGTRGVGKTTFLLQYAKEKFGTDRSCLFINMNNFYFSGHSLVDFANEFQKRGGKVLLID
                     QVFKHPEWSKELRMCYDRFPSLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFL
                     NLQTGMKFRAYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENL
                     LKTMNMMVEVDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDVQTSRATVMN
                     YIKYLADARLINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNTLW
                     KDHKVHKGDKNVSFMVDEVMPFKICAEGTKIKNNPDVTYALQKAEIGRGNQIPLWMFGF
                     LY"
     CDS             3042..6599
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_3"
                     /sec_met_domain="PFOR_II (E-value: 5e-19, bitscore: 58.2,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 7.1e-83, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 7.8e-32, bitscore: 100.3,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 2.5e-12, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 4.6e-08, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.5e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.2e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKSIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQIISVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIAMEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLTVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKSKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTMNEKGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIASDCCPAEYKEVFAEWINNMLDAEKTKE
                     LAEKIIPMVEAAKDKCNHCKQIADLQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGADTAE"
     CDS             6724..6912
                     /locus_tag="ctg43_4"
                     /transl_table=11
                     /translation="MIGFVIWIIGLILTFRAAIEIWNINAAVEKRLIAIVLIVLTSWLG
                     LLFYYFYGKERMAGWLK"
     CDS             complement(6923..7783)
                     /locus_tag="ctg43_5"
                     /transl_table=11
                     /translation="MNKIKMIAAMFIAGILLTFVSCGDNGKSKKISIAYANWSEGIAMT
                     NLAKAIFEDQGYDVKLLNADLAPIFTSISRKKADVFMDVWMPVTMEDYMKQYGDKLEVI
                     GDIYDGARIGLVIPDYVTINSIEELNAEKERFSGQIVGIDAGAGIMKATDQAIKDYGLD
                     YKLMTSSGPAMTASLKKAIDKKDWIVVTGWTPHWMFDRFKLKVLQDPKLIYGNTESIHT
                     IAWKGFSEKDPFAAELLGNIRLTDAEISSLMTALEEAQTTERQAARQWMEEHQELVNSW
                     IPEKD"
     CDS             complement(7811..8641)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 91.7; E-value: 1.6e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg43_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.9e-29, bitscore:
                     91.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIETAINWLTEHFASFFDALSMGIGGFIDGFQHVLFGIP
                     FYITIAVLAALAWFKSGKGTAVFTLLGLLLIYGMGFWEETMQTLALVLSSTCLALLLGV
                     PLGIWTANSDRCNKIMRPVLDFMQTMPAFVYLIPAVLFFGLGTVPGAFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATPWQLLYKVQLPLALPTILTGINQTIMMSLSMVVIA
                     AMISAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIVLDRITQGMADNRKSKKK"
     CDS             complement(8638..9864)
                     /locus_tag="ctg43_7"
                     /transl_table=11
                     /translation="MSKIEIKDLYLVFGNEKQKALKMLKEGKTKSEILKATGCTVAVKD
                     ANLSINEGEIFVIMGLSGSGKSTLLRCINRLIRPTSGEVIINGTDIAKVSDKELLQIRR
                     KELAMVFQNFGLLPHRSVLHNIAFGLELQGVKKGEREQKAMESMQLVGLKGYENQMVSE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLTLQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEIVQIGTSEEILTEPANAYVERFVENVDRSKIITASSVMVD
                     KPIVARLKKEGPEVLIRKMRERNLTVLPVVDSNNLLVGEVRLNDLLKLRKEQIRSIESV
                     VRHEVHSVLGDTVLEDILPLMTKTNSPIWVVNENREFEGVVPLSSLIIEVTGKDKEEIN
                     EIIQNAIEL"
     CDS             10337..11623
                     /locus_tag="ctg43_8"
                     /transl_table=11
                     /translation="MFNRAITIFLGKDNCHYTTKEKQTGTATLDDKSQVQFLSKKNPKM
                     PFFYSRRNLYMIGFLLAFIVTLLEFIRGRHQNFMVFSDATQFFWQGISPYTTEFVEAHG
                     RYFLYSPVFTVLFAPFAYLPAWLGPFAWNLFNYSLFFMAIFTLPQQFTQQQKCRMFLFL
                     LLILGQSLLSFQYNITVAYLFLFAYTLLEKDRGFLAVLLIMISGCTKVYGIFELALLLC
                     YPHVWRNFGYAVTMGIVLLALPLIKIAPADLLPYYEEWCHSLAVHQSAGAYDSFFYARP
                     IAAWTLPHFRALQIGMLGLLTLLFLGNFRKWSSFAFRAQALGILMGWVVLLSDSAEKHT
                     YIIALAGFMLWYWSRPTRTATDKILFWCCFVLLCIVPIDIFVPIPIRDFITRTLWLHVW
                     VFFIVWIRMIWLTFLASFIHPRATNVLSD"
     CDS             complement(11667..11918)
                     /locus_tag="ctg43_9"
                     /transl_table=11
                     /translation="MKDYKVDKESFSESFRKEVYEVVSQIPVGKVSTYGGIALLLGAPQ
                     CSRMVGRALKEVPDELSIPCHRVVNSTGRLVPGWVEQK"
     CDS             complement(11946..14699)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 64.3; E-value: 4.2e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_10"
                     /sec_met_domain="Peripla_BP_1 (E-value: 7.4e-21, bitscore:
                     64.3, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTMRYLKWMLVLFGLIGMTACRQDTPRFRIGVAQCSDDSWRHKM
                     NDEILREAMFYNGVSVEIRSAGDDNSKQAEDVHYFMDEGVDLLIISANEAAPMTPIVEE
                     AYQKGIPVILVDRKILSDKYTAYIGADNYEIGRSVGNYIASSLKGKGNIVELTGLSGST
                     PAMERHQGFMAAISKFPDIKLIDKADAAWERGPAEIEMDSMLRRHPKIDAVYAHNDRIA
                     PGAYQAAKMAGREKEMIFVGIDALPGKGNGLELVLDSVLDATFIYPTNGDKVLQLAMDI
                     LEKKPYPKETVMNTAVVDRTNAHVMQLQTTHISELDKKIETLNGRIGGYLSQVATQQVV
                     LYGSLIILLLVAGLLLVVYKSLRSKNRLNKELFKQKQQLEEQRDKLEEQRDQLIQLSHQ
                     LEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADKTLSGDQHRMLMLIQRNVNILLR
                     LVNQILDFRKYENGKMEYTPVTVDVLSSFEGWNESFQAAARKKHIHFSFDSMPDTDYHT
                     LADMEKLERIYFNLLSNAFKFTPENGKIAVRLSSLSKEDKRWIRFTVANTGSMISAEHI
                     RNVFDRFYKIDMHHTGSGIGLALVKAFVEMHGGMISVESDEKQGTVFTVELPVQSCEAV
                     AAEPDTTLVSADSRTTDVLLAEEEELEKGYDSSKPSVLIIDDNEDIRSYVHTLLHTDYT
                     VIEAADGSEGIRKAMKYVPDLIISDVMMPGIDGIECCRRLKSELQTCHIPVILLTACSL
                     DEQRIQGYDGGADSYISKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDK
                     DFVERFKSLIEEKMGDSGLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKA
                     ASLLASSDMTVAEIGYEVGFSSPSYFAKCYKEQFGESPTDFLKRKG"
     CDS             complement(15032..16258)
                     /locus_tag="ctg43_11"
                     /transl_table=11
                     /translation="MFFFLIVPLFLALFYKPIAYLCGRFLNNKSKRENYFMKHISNFLR
                     SKSWNVFLFLYLALPLFAQKEYKIDQVSVVNVGDGRLLFQELKTEKALNGEHRIIDGYH
                     SAYVLASFKDGFYDGGYKEYVDNILITEGSYKEGRKDGLFKINSKFDGKLKEEKSYKEG
                     KLDGTSKSYFTTGKVESERNFRMGKEHGKQLSYESDGTLRKEHNYKDGKQVGKQYTFLK
                     GTYDLYETVYFNEEGFQDGEYSSVFTFGSPRILGSYKNGKKNGRWTTFAESGDTLMIET
                     YLDGKEDGLHVSFANGSGVRQKEYYMKNDRKDGLYREYNLENGELRYEATYQAGRLHGK
                     ERRLIVSNRFDYWETSTYVNGRQNGPFEARYVKNDQLRECGEYKNGHRVGRWKRYTIDG
                     KLEKEWDEN"
ORIGIN
        1 caagctgata aggactaaag gtcatgtcac tctttttcat cttttattca ttttagttga
       61 tacttatagt agtcaaccaa atccagggta agacaactac tgttgatttg attgacttaa
      121 ccgcatgttc caatcacatt gaacgcatca gctacttcaa tagtactgct ctctctgaaa
      181 acattaaatc atatatcagt caataataca taaattatca gtccttaata cttgatttct
      241 caattattaa tatctgagaa atcaaacgtt aacagttgag atatcagata ttaacatcct
      301 gtaaatcaaa gaataacaca gtaaaaacag tatttatcag gacgatgcag agtgagagca
      361 agtccttgct ctcactctgc taccactgga tctctaacag ctaaaacatc gatgaataaa
      421 gggatacaga cgaactgtta gagcatgaga gcaaaagcac tatctttttc actgggggag
      481 agtaagcaaa agaaacgcac gataccggct ttgaggcgtc accggtacta acggcaaata
      541 tccggcacac acccgattat tctctacgga caaagggaac gaagccgaca tctgccgatg
      601 ttcctccaaa gcctgaccgg ctaaaggata ataatcaatc cgaaaaactc cttccgcatc
      661 cgcagccaaa taacgatccg tcaagagcca tgccaccacc cccatattca ttcgcagatt
      721 aatttcgaca caaggatgaa tccggtaaac aggcgcttca tccggaaaat gacaaatcat
      781 catatccact cccaagtatc catgataaaa gccaccgaac aaagctgaca attcttcttc
      841 caaacgagtc cgcagcctga taaattcttc ttgtggcaca taagccgata gtttctgcag
      901 aatcttctcg tcagacagca agtcattccc tgcatacatc ccactcccac ccgtgtggaa
      961 gaccgaatat ccggcaaaaa caacccttcc tctcccgtca gcataaaact ccatagcgaa
     1021 atcttccacc ttattatata taggttcgcc taccacccca ccctgagaag cagcgacacg
     1081 ggcacaccaa ccggaaataa aagtagtaaa tatgccttta caccaattca atcctttccc
     1141 gcttccggaa agcggagctt ttaacaagca cgcttcccgc ccttcgacga acgcactgca
     1201 ctccgccaaa gtactcaaat aaaaagattc tccacagaag tattcattca accgcaaccc
     1261 aggcaacaac tttaccgcct gcagacgatg cgaatgctct ctcagaatat tcatataatc
     1321 cgcagaaggc agctccgtct gacctgcccc caatgtcatc aaacgcttcc gcaaagcagg
     1381 gtcccaaccc cacggagaga acttccagtc tttaccgtca gccacttccg gttccgtcaa
     1441 caaggccaca tccatgccca aaagttcact ctttgttttc aggaagtccg cattataagc
     1501 agacggtgca agcaccgcac ttcccgcttc ggcataccac ataggaagca acgccaggtc
     1561 actcgccatc tgtcgggcgg aagccggcgc catatagttc gtctcaccgc ttgccaacgc
     1621 catatcatgc tccggattga atatataaac aggtcttttc gtcatgtcaa agatggattc
     1681 aacacattat tctgcaaata tatacaggaa ataatcagga acttacacaa taaagagaaa
     1741 cttataaatt aaagcacatt tttgctatct ctactttgca aatcctaaaa aaagcactat
     1801 atttgccagc cgaaaaacaa agaaacgaaa tggaatcatt ctatcgcaca cacgcctacc
     1861 tcgttgagca caccaatgcc cccgttcgcc gcgatcttat ggacgagatc gactggagtg
     1921 accgtctgat tggtatcaaa gggacacgtg gcgtaggaaa aaccactttc ctcctgcagt
     1981 acgccaaaga gaaattcggc accgaccgtt cctgtctgtt catcaatatg aacaactttt
     2041 atttctccgg tcacagcctt gttgacttcg ccaacgagtt tcagaaacgt ggcggaaaag
     2101 tactgctgat cgaccaggtg ttcaaacatc ccgaatggag caaagagcta cgaatgtgct
     2161 atgaccgttt ccccagcctg aagattgtct tcaccggttc ttccgtcatg cgactcaaag
     2221 aggaaaacct cgaattgcgt gacattgcga aaagttataa cctgcgcgga ttctctttcc
     2281 gtgaatttct gaacctgcag acaggaatga aattccgggc atacagcctc gaagaaatcc
     2341 tcagtacaca tgaacagata gccaaaggag tactttccaa agtacgaccg ctggattatt
     2401 ttcaggatta cctgcatcat ggtttctacc ctttcttcct tgaaaaacgt aatttctcgg
     2461 agaatctgct gaaaacaatg aacatgatgg tagaagtgga tatcttgctg atcaaacaaa
     2521 ttgagctgaa atatctttca aagataaaaa aattactata tttgttggct gtggacggac
     2581 cgaaagctcc gaacgtgagc caactggcaa gtgacgtaca gacatcccgc gctacggtaa
     2641 tgaactatat caagtatctg gcagacgcgc gtctgattaa tctggtttac ccgaaaggag
     2701 aagaattccc aaagaaaccg tcaaagatta tgatgcacaa ctctaacctg atgtactcca
     2761 tttatccggt gaaagtggaa gaacaggatg tactcgacac gttcttcgtt aacactttat
     2821 ggaaagacca taaggtacat aaaggagata aaaacgtctc tttcatggta gacgaagtga
     2881 tgccgttcaa aatttgtgcg gaaggtacaa aaataaagaa taacccggac gtgacgtatg
     2941 cgttgcaaaa ggccgagata ggccgcggca accaaatacc tctttggatg ttcggattct
     3001 tatactaaaa agatttattt acttaaatat ttaatttagt tatgactaaa cagaagaaat
     3061 tcatcacatg tgatggtaac caagctgcag cacatatctc gtatatgttc tctgaagtag
     3121 cagctatcta ccccatcact ccttcttcga ctatggctga gtacgtagac gaatgggctg
     3181 ccgcaggacg taagaacatc ttcggcgaaa cagtattggt acaggaaatg caatctgaag
     3241 gtggtgctgc cggtgcagtt cacggttctc ttcaggctgg tgcattgact actacttaca
     3301 ctgcttctca gggtcttctt ttgatgatcc ctaacatgta caagattgcc ggtgaattct
     3361 tgccttgtgt attccacgtt tctgctcgta cactggcttc tcacgcattg tgtatcttcg
     3421 gtgaccatca ggacgtaatg tcagctcgtc aaaccggctt cgctatgttg gcagaaggtt
     3481 ctgtacagga agttatggat ttggcaggtg ttgctcatct ggctactatc aaatcacgcg
     3541 ttccgttcat gaacttcttc gatggtttcc gtacttctca cgaaatccag aagatcgaaa
     3601 tgttggaaaa cgacgacctc gctccgctga tcgaccagga agctttggct gaattccgtg
     3661 cccgtgcact gaatccgatg aagccggttg cccgtggtat ggctgaaaac cccgaccact
     3721 tcttccaaca tcgtgaatca tgcaataact actatgaagc agttcctgct atcgtagaag
     3781 aatacatgaa cgaaatttcc aagatcacag gccgcaaata cggtttgttc gattactacg
     3841 gtgcagaaga tgcagaacgc gtaattatcg caatgggttc tgtaactgaa gctgcccgcg
     3901 aagctatcga ccacttggta gcaaacggcg aaaaagtagg tatggttgcc gtacacttgt
     3961 atcgtccgtt ctctgctaaa cacttcctgg ctgctgtacc caagactgca aagagcatcg
     4021 cagtgcttga ccgtacaaaa gaaccgggtg ctaacggcga acctctttac cttgacgtta
     4081 aagactgctt ctatggcgca gaaaatgctc ctgttatcgt tggcggtcgc tacggtctgg
     4141 gttcaaaaga taccactccg gcacagatca tctctgtatt cgaaaacttg gctatgccaa
     4201 tgccgaagaa ccacttcact atcggtatcg tagacgacgt tacgttcact tctcttcctc
     4261 agaaagaaga aatcgctctg ggcggtgaag gtatgttcga agctaaattc tacggtctgg
     4321 gtgctgacgg cacagtaggt gccaacaaga actctgttaa gattatcggt gacaacaccg
     4381 acaaacactg tcaggcttac ttctcttacg actccaagaa gtcgggtggt ttcacttgtt
     4441 ctcacttgcg tttcggtgat actccgatcc gttctactta cttggtaaat actccgaact
     4501 tcgttgcttg tcacgttcag gcttacctgc acatgtacga cgtaacacgt ggtttgcgta
     4561 agaacggttc tttcttgctg aataccatct gggaaggcga agaactggct aagaacctgc
     4621 ctaacaaggt gaagaaatac tttgcacaga acaacatctc tgtatactat atcaacgcaa
     4681 ctcagattgc aatggaaatt ggtttgggca accgtaccaa tacaatcctt cagtctgcat
     4741 tcttccgtat cacaggcgta atccctgtag atcaagctgt tgaacagatg aagaaattca
     4801 tcgttaagtc ttacggcaag aagggtgaag acgttgttaa caagaactac gctgctgtag
     4861 accgcggtgg tgaatacaag actctgactg tcgatcctgc ttgggctaac ctgccggatg
     4921 atgcaaaagc agaaaacaat gatcctgctt tcatcaacga agtagttcgt ccgatcaatg
     4981 cacaggacgg tgacttgctg ccggtatctg cattcaaggg tatcgaagac ggtacttggt
     5041 atcaaggtac ttccaaatac gaaaaacgtg gtgtagctgc attcgttccc gaatggaatg
     5101 ctgaaaactg tattcagtgt aacaagtgtg cttacgtttg tcctcacgct tctatccgtc
     5161 cgttcgtact cgatgctgaa gagcagaagg gtgctaagtt cgagcaactg aaagctgtag
     5221 gtaaagcatt cgatggtatg acattccgta ttcaggtaga cgttctcgac tgtctgggtt
     5281 gcggtaactg tgccgacatc tgtccgggta atccgaagaa gggtggcaag gcattgacca
     5341 tgaaacacct tgaaagccag ttggccgaag ctgataactg gacttactgc gctgaaaacg
     5401 tgaagagcaa acaacacctg gtagacatca aggctaacgt gaagaactct cagttcgcaa
     5461 ctccgttgtt tgagttctca ggcgcttgct ccggttgtgg tgaaactccg tacgtgaaac
     5521 tgatttctca gttgttcggt gaccgtgaaa tggttgctaa cgctacagga tgttcttcta
     5581 tctactccgg ttcagttcct tctactccgt acactatgaa cgaaaagggt cacggtcctg
     5641 catgggctaa ctccttgttc gaagacttct gtgaatttgg tctgggtatg gaactggcta
     5701 acgaaaagat gcgtgcccgt ctggtgaaag taatgaacga agctatcgct tctgattgct
     5761 gcccggctga atacaaagaa gtatttgctg aatggatcaa caatatgctg gatgcagaaa
     5821 agactaagga actggccgaa aagatcattc cgatggtaga agctgctaaa gataaatgca
     5881 accactgcaa gcaaatcgct gatctgcaac aatatcttgt taaacgcagc caatggatca
     5941 tcggtggtga cggtgcttct tatgatatcg gttacggtgg tcttgaccat gtaatcgctt
     6001 ccggtaagga cgttaacatc cttgtattgg atactgaggt ttactctaac acaggtggtc
     6061 agtcttctaa agctactccg gtaggcgcta tcgctaagtt tgctgctgca ggtaagcgtg
     6121 tacgtaagaa agacctcggt ctgatggcta ctacttacgg ttatgtatat gttgctcaga
     6181 ttgctatggg tgctgaccag gctcagactc tgaaagctat ccgtgaagct gaagcatatc
     6241 cgggaccatc actgatcatc gcttacgctc catgtatcaa ccacggtctg aaagccggta
     6301 tgggtaagag ccaggaagaa gaagaaaagg ctgttaagtg cggttactgg cacttgtggc
     6361 gttacaaccc tgctttggaa gaagaaggca agaatccgtt ccaactggat agcaaagaac
     6421 ctaactggga agacttccaa ggtttcttga agggtgaagt tcgttacgct tctgtaatga
     6481 aacaatatcc tgctgaagct gaagaactgt ttaaagctgc tgaagaaaac gctaaatggc
     6541 gttacaacag ctacaaacgt cttgccagag aaaactgggg agctgataca gctgaataat
     6601 aagtagaaat actttataca taataaaagg caggaatcct ggaaacagat tcctgccttt
     6661 tttgtttata tcttagaagt aacgattact tctcacgaag atattcatta aaactctaaa
     6721 gatatgatcg gatttgttat ttggattatc ggtttgatac tgactttcag agctgccata
     6781 gagatttgga atataaatgc ggctgtagag aaaagactta tagcgattgt attaatcgtt
     6841 cttaccagct ggctgggact acttttctac tacttctatg gtaaagaaag aatggcagga
     6901 tggttgaagt agtgtttgca tatcaatctt tctcaggaat ccaactgttt accagttcct
     6961 gatgttcttc catccattga cgggcagcct gtctttccgt tgtctgcgcc tcttccagag
     7021 cagtcattaa agagctgatt tccgcatctg tcagacgaat gttgcccaaa agttcggcag
     7081 caaaagggtc tttctcgcta aaacctttcc atgctatggt atgaatggat tccgtatttc
     7141 catatatcag cttcgggtcc tgaagaactt tcagcttgaa acggtcgaac atccagtgag
     7201 gcgtccatcc cgtcacgaca atccagtctt tcttatcaat cgctttcttt agggaagcag
     7261 tcatggcagg tccgctcgaa gtcatcagtt tataatccaa tccatagtct ttgatggcct
     7321 gatcggtagc tttcataata ccggctccgg catcaatacc gacaatctga ccggagaaac
     7381 gttccttttc cgcgttcagt tcttcgattg agttgatcgt aacgtaatcc ggaatcacca
     7441 gcccgatacg ggcaccatca taaatatccc cgataacttc gagtttatcc ccgtattgtt
     7501 tcatataatc ttccatagtg acaggcatcc agacatccat aaatacgtct gctttcttac
     7561 gggagataga ggtaaatata ggtgcaaggt cggcattcag caactttaca tcgtacccct
     7621 gatcttcaaa aatcgctttg gcaaggtttg tcattgcaat accttccgac cagttggcat
     7681 aagcgatact tatcttctta ctctttccgt tgtctccgca ggaaacgaag gttaagagta
     7741 tgccggcaat aaacattgcc gcaatcattt ttatcttatt cattgattat tcctttcttt
     7801 ggtgtgattc ttatttcttt ttactttttc tgttatctgc cataccctga gtgatgcggt
     7861 ccagcacgat cgccaatatc acgactgcga taccgccttc aaatccgagt ccgattttca
     7921 tttgggtgat acctttcagc acgatttctc ccaaccctcc cgcagaaatc atggcggcaa
     7981 tcactaccat cgaaagtgac atcatgatcg tctgattgat tcccgtcaga atagtaggca
     8041 atgccaaagg caattgcacc ttataaagaa gctgccaggg agtagctcca aaagaacggg
     8101 aggcttctac tacattttta ggaacctgac gaatgcccag accagtcaga cgaaccacag
     8161 gaggcattgc aaagatgatg gtggcaaaag ctcccggcac agttcccaat ccgaagaata
     8221 gaacggcagg aatcagatag acaaaggcag gcattgtctg cataaagtcg aggacagggc
     8281 gcattatctt gttacaacga tcactgttgg cagtccagat tcccaacgga acgcctaaaa
     8341 gcaatgccag acaagtggaa gaaagtacca atgccaatgt ctgcatcgtt tcttcccaaa
     8401 agcccatgcc gtaaataagc aataaaccca agagggtaaa tacggctgtc cccttacccg
     8461 acttaaacca ggcgagcgca gccagcactg caattgtgat ataaaaaggt attccaaaca
     8521 gtacgtgctg aaaaccgtct atgaatcctc cgatccccat gctgagagca tcaaaaaagg
     8581 aagcaaaatg ttctgtgagc caattaatgg cagtctctat atattgtccg atatttatca
     8641 taattctatt gcgttttgaa tgatttcatt aatttcttct ttatcttttc ccgttacttc
     8701 gatgatcaat gaggaaagtg gcactacgcc ttcaaactcc cgattctcat ttacgaccca
     8761 gattggcgag ttcgtttttg tcatcaacgg aagaatatct tccagcaccg tatcacccag
     8821 cactgaatga acttcatgcc ttactacgga ctcgatggag cggatttgct cttttcgtag
     8881 tttcagcaag tcattcaacc gcacctctcc tactaacaga ttattggaat cgactaccgg
     8941 aagaacggtc agattccgtt cgcgcatctt acggatcagc acctccgggc cttctttctt
     9001 caaacgtgcc actatgggtt tatctaccat aacagaggaa gctgttataa tcttgcttcg
     9061 atctacattc tccacaaatc gttctacata agcgttggca ggttcggtca ggatttcttc
     9121 cgatgtaccg atttgtacaa tttctccatc cttcatgata gcaatccggt cacccaattt
     9181 aatcgcttca ctcaggtcgt gagtaataaa gacaatcgtt tttttcatct tcgactgcaa
     9241 agtcagcagt tcatcctgca tctgcacacg gatcaaagga tcgagtgccg agaaggcctc
     9301 atccatcaac aggacttcgg gattattggc caaagcccgc gccagcccga cacgctgctg
     9361 catcccaccc gacagttcac ttaccatctg attctcgtag cctttcagcc ccaccagttg
     9421 catactttcc atcgctttct gctcccgttc tccctttttt actccctgta gttcgagccc
     9481 gaaagctata ttatgcaaga cagaacggtg aggaagcaga ccgaagttct gaaagaccat
     9541 agccagttct ttccggcgaa tctgcaacag ttccttatcc gacactttgg ctatgtctgt
     9601 tccattgata atcacttctc cggaagtagg gcgtatcaaa cggttgatgc agcggagtaa
     9661 agtggacttt ccactaccgg acagccccat aatgacgaat atttcgcctt cattaatgga
     9721 aagattcgca tctttcaccg caactgtaca tccggtcgct ttcaatattt cactttttgt
     9781 tttaccttct ttcaacatct tcaaagcctt ctgcttctca ttgccaaaaa ccagatagag
     9841 atctttaatt tctattttac tcatacaata aaatggttta ggttattaaa ataatataca
     9901 cagcaagaca agaacaaacg ataacaggaa tctttcttta tatcgtataa agttctgatt
     9961 taaataaggg acaaataaca atgaatcccg aaataattaa taaaatgatt attgacagac
    10021 tgagtaatta aaaaaggaat agaatttgat aagataatcc tttcaacgaa tagcaaaaaa
    10081 tagcattttt atgtataaaa acagcctgtt ccagtatctt gctggcacaa agatacaaaa
    10141 aacggattaa acatacaaat tatattcaaa atccggggca tacagagggc tttatttgta
    10201 atgatatgga aagtttccgg gtaatattcc cctatcactc agcaaaatag aacaaaccgg
    10261 cagataaata taaaataagt ttgaatattt cacttaaaca ccgtatattt ggcgtcaata
    10321 actaaactag atttatatgt tcaacagggc tattacaatt ttcctgggga aggataattg
    10381 tcattacaca acaaaagaaa aacaaacagg tactgccaca ctagacgaca aaagccaagt
    10441 acagttcctt agtaaaaaga accccaaaat gccgtttttc tatagccggc ggaatctcta
    10501 catgataggt ttcctgctcg cttttatagt gactctgctc gaatttatac gaggacggca
    10561 tcaaaacttt atggtcttct cggacgctac tcaattcttc tggcaaggca tcagcccata
    10621 cacaactgaa tttgtagaag ctcacggacg ctacttcctt tattctccag ttttcacggt
    10681 attgttcgct ccgtttgcgt atctgcctgc atggctggga cctttcgcgt ggaatctatt
    10741 caattattcg ctgttcttta tggcgatctt cacgctgccc caacaattca cccagcagca
    10801 gaaatgccgt atgttccttt ttctgttact gattttagga caaagtttac tttcatttca
    10861 gtataacata acggtagcct atttattctt attcgcctat acgttattgg aaaaagaccg
    10921 tggatttctg gctgttctgt taatcatgat ttcgggatgt accaaagtat atggaatttt
    10981 cgaactggca ttgttgctgt gctatcctca cgtatggcgt aactttggct atgccgttac
    11041 aatgggcatt gtattgcttg cattaccgtt aatcaaaata gctcctgcag atttgctccc
    11101 ctattatgaa gaatggtgcc atagtcttgc tgttcatcag tccgccggag cttatgattc
    11161 atttttctat gcccgcccca ttgcagcatg gacattgcca cacttccgtg cacttcagat
    11221 aggaatgctc ggcttgctga ctctgctctt tttggggaat ttccgcaaat ggtcgtcttt
    11281 tgccttccgt gcccaggctt tgggcattct catgggctgg gtagtattac tgagtgactc
    11341 cgccgagaag catacctata ttatcgcatt ggcaggtttc atgctctggt attggagcag
    11401 accaacacgt accgcaacag acaagattct attttggtgc tgttttgtgc tgttatgtat
    11461 cgttcctatc gacatattcg tccctatacc catcagagat ttcattacca ggaccttatg
    11521 gcttcatgta tgggttttct ttattgtatg gatacggatg atatggctta ccttccttgc
    11581 atccttcatt catccacgtg ccacaaatgt tctttcagat taacgcatcc gttagctttg
    11641 aaagaaactt cttctgccag caagagttat ttttgttcca cccaaccggg caccagcctt
    11701 ccggtggaat ttacaactct atggcaggga atggataatt catccggcac ttctttcaat
    11761 gcacgtccca ccatccgcga gcattggggt gcccccaaca gcaaagcaat acctccataa
    11821 gtagatactt ttcccacagg tatctgggat acgacttcgt acacttcctt ccgaaaggat
    11881 tcggaaaagc tctctttatc tactttataa tctttcatat atccctcttt acgatatcaa
    11941 tgaaatcatc ctttcctttt caggaaatct gtcgggctct ctccaaactg ctctttatag
    12001 cacttggcga aataagaagg tgaactgaaa ccgacttcat aaccaatctc cgctacggtc
    12061 atgtccgaag aagcaagcaa agaagctgcc ttcttcaaac gggcgatacg gagcaattca
    12121 ttcggagagt agttagtcaa tgatttaatc ttgcgataaa gctgcacacg gcttagtccc
    12181 atgtctttgc ccaagtcctc cacattcaaa ccggagtctc ccattttctc ttcaatcaat
    12241 gacttgaatc tttctacaaa atccttgtcc atatcgcaga catcttcttt tgccaatgtc
    12301 tgcccgtcac caaagaactg tttcagacga cggtgagaat cgatcagatt gcggacacgt
    12361 gccagcaaca gctgtgaact gaacggcttt gaaatataag aatccgcacc accgtcatat
    12421 ccctgaatac gctgttcgtc cagtgaacac gctgtcagca gaataaccgg aatatgacag
    12481 gtctgtaact cacttttcag ccggcggcaa cattcaatgc catcaatgcc cggcatcatc
    12541 acatcagaaa tgatcaggtc cggaacatac ttcatagcct tacggattcc ttcggagccg
    12601 tctgccgctt caatcaccgt atagtctgta tgcaacaacg tatggacata cgaacggata
    12661 tcctcattat catcaataat cagtacggac ggtttggaag agtcatatcc tttttccagt
    12721 tcttcctctt ccgccaatag aacatctgtt gtacgggaat ccgcagaaac aagggtggta
    12781 tccggttcgg cagcaacagc ctcacaagac tgtacaggca gttcaacggt aaagaccgtg
    12841 ccctgtttct catcgctctc tacggagatc ataccaccgt gcatttctac gaaggctttt
    12901 accaatgcca gtccgattcc cgaaccggta tggtgcatat cgatcttata gaaacggtcg
    12961 aatacattgc gaatatgttc ggcagaaatc atagaaccgg tatttgccac cgtgaaacgt
    13021 atccatcgct tgtcctcttt actaagggaa gacagacgga cggctatttt cccgttttcc
    13081 ggtgtaaact taaaggcatt ggacagaaga ttgaaataaa tacgttccag cttctccatg
    13141 tctgccagtg tatgataatc cgtatccggc atactatcaa aagaaaaatg gatatgcttc
    13201 ttacgggctg ccgcctgaaa agactcattc catccttcga aagaagaaag gacatccacc
    13261 gtaaccggag tatattccat cttgccgttt tcatatttac ggaaatccag aatctgattg
    13321 accagacgca gaagaatgtt cacattccgc tgaatcagca tgagcatccg gtgctgatct
    13381 ccgctcagtg tcttgtccgc caacaaatgt tctaccgggt cggcaaccaa tgtcaacgga
    13441 gtacggaagt cgtgagaaat attggtgaaa aagaccagct tggcatgggt agcttcttcc
    13501 agttgatgag agagctgtat caattggtca cgctgttctt ccagtttgtc acgctgctct
    13561 tccaattgct gcttctgctt aaaaagctct ttattcaagc gattcttaga gcggagtgat
    13621 ttataaacga ccaataataa gccggctacc aataaaagga taatcagact gccgtataaa
    13681 acgacctgtt gtgtagctac ctgagagaga tagccaccga tacgtccgtt gagcgtttca
    13741 atctttttgt cgagttcgga aatgtgtgtg gtctgcaact gcatgacgtg tgcgttggta
    13801 cggtccacaa cagcggtatt catcaccgtt tctttgggat agggtttctt ctccagaatg
    13861 tccatagcca gttgcagtac cttatcgcca ttggtcggat agataaaggt ggcatccagc
    13921 acactgtcca gtaccagttc cagtccgttt cccttacccg gcaaggcatc tatgccgaca
    13981 aaaatcattt ccttctcccg ccctgccatc tttgctgcct gataggcacc cggagcgata
    14041 cggtcattat gggcatacac agcatcaatc ttaggatgcc tccgaagcat actatccatt
    14101 tctatctctg ccggaccacg ttcccacgca gcatccgctt tatcaatcag ctttatatcc
    14161 gggaatttac tgatggcagc cataaatccc tgatgccgtt ccattgcagg agtcgaaccg
    14221 ctcaatcctg tcagttctac tatatttccc ttccctttca gactggaggc aatatagttt
    14281 cctaccgaac gaccgatttc ataattatcg gctccgatat aggcagtata tttatccgaa
    14341 agaatcttcc ggtctacaag aataacgggg atgcctttct gataagcttc ttctacaatc
    14401 ggagtcatag gagcagcttc gttagcggaa ataatcagca gatcgactcc ttcgtccata
    14461 aaataatgga catcttccgc ctgcttactg ttatcatccc ctgccgaacg gatttccacc
    14521 gaaacaccat tataaaacat cgcttcccga agaatctcat cattcatctt atgtcgccat
    14581 gaatcatcgc tgcattgagc caccccaata cgaaaacggg gtgtatcctg ccggcaagcc
    14641 gtcatcccga ttaaaccaaa cagcaccagc atccacttca gatatctcat cgtcttcatc
    14701 catctcatca tttcatagtt ctttctgtaa tccaattaag aacaaaaata agaaataata
    14761 ctgtaaagtt ctctaacttc agctatttat tattctaaaa agaaggaaag cagtcctctt
    14821 tcagaccatc ggaaagtatt aacaaaagta taaagcgtaa aacaaacact taatcaatgt
    14881 tataaaacat agcgttttac ttggataatt tgcagatttc acagaagtcc gtatctttgc
    14941 actgtgtttt tcatagtatt agatttaagg ttaacaaagg ttggagcaag gcgttgctcc
    15001 tttttttatg ctctgacctt tcatctaccg gttagttttc atcccattcc ttttccagtt
    15061 taccatcaat agtgtagcgt ttccatcgtc ctacacggtg accattctta tattccccac
    15121 attcacgaag ctggtcattc tttacataac gagcttcgaa cggtccgttc tgccttccgt
    15181 tcacataggt agaagtttcc caataatcaa agcggttgct cactatcagc cgtcgttcct
    15241 tgccatgcaa tctgccggcc tgataggtag cttcatatct caattcacca ttttccaaat
    15301 tatattcacg gtataaaccg tctttacgat cgttcttcat ataatattct ttctgcctta
    15361 ccccacttcc gttggcaaat gagacatgga gtccatcttc ttttccatcc agataggttt
    15421 caatcatcag cgtatctccg ctttcagcaa aagtagtcca acgaccattc ttctttccat
    15481 tcttataact acccagtata cgtggcgagc caaacgtaaa cacggacgaa tattcaccgt
    15541 cctgaaaacc ttcttcattg aaataaacgg tctcatacaa atcatatgta cctttcagaa
    15601 aagtatactg tttgcctacc tgcttcccgt ccttgtaatt atgctctttc cgcaaagtac
    15661 cgtcagattc gtacgacagt tgcttcccgt gctctttccc catccggaag tttctttcac
    15721 tttccacttt tccggtagta aagtaacttt tgctcgtacc gtccagctta ccttccttat
    15781 aggacttttc ttctttcagc ttaccgtcaa acttggagtt aatcttgaag aggccatcct
    15841 tccgcccttc tttataactt ccttccgtta ttaatatatt gtccacatat tctttgtatc
    15901 cgccatcata aaaaccatct ttaaaagatg ccagcacata ggcggaatga taaccatcta
    15961 tgatgcgatg ttcgccattc aatgcttttt ccgttttcag ttcctgaaac aacagtctgc
    16021 catcgcctac attaacaaca gatacctgat cgatcttata ttccttttgc gcaaacaaag
    16081 gaagagcaag atataaaaac aaaaatacgt tccagctttt tgatctgagg aagttcgaaa
    16141 tgtgtttcat aaagtagttt tctctttttg atttattatt taaaaacctg ccgcaaagat
    16201 aggcaatcgg cttataaaac aaggcaagaa agagggggac aattagaaaa aagaacatct
    16261 gttattatca ttctaataat taacagatta agtagtaaat caaaacacag ggaaggggga
    16321 catttactga aataagaaac agaaaagaag atgtgtcaaa agcaactaaa ttcccctcct
    16381 tcaggaagga ggagagttta gttgcttttg acacatttac atttgcagta ttaaatatca
    16441 caacaaaata taagtgtata tttgaaaagt agagttgcag tgaactaact ttgacactag
    16501 tcttaaatga
//
