LOCUS       c00011_gnlPro..        16246 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AOPGDALD_57.
ACCESSION   c00011_gnlPro..
VERSION     c00011_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 09:53:49
            Original ID  :: gnl|Prokka|AOPGDALD_57
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16246
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16246
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2694:6246](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2695..6246
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16246
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16246
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(122..1321)
                     /locus_tag="ctg11_1"
                     /transl_table=11
                     /translation="MTKKALYIFNPEHDLALASGETNYMAPASARQMASELALLPMWYA
                     EEGSVVLAPSAYNLDYVKKIQELLGLSVDLMTEPELASERNLDIRPWGWDIAIRKRLLD
                     LGVEESELPSIEQLDKLRFCSHRSCAVGLLPQLQLGACFCGESFYLTFPEEWKSFVESH
                     DTCLLKAPLSGSGKGLNWCKGVYTPSISGWCSRIGNQQGGVIGEPLYNKVEDFAMEFRS
                     SGNGRFGFAGYSQFRTGGSGAYEGNLLISDAAIERNLSEYIPVEEIYKLRDRLEQELSL
                     RFGTIYNGYLGVDMMICRFPESPVYRIHPCVEINLRMNMGVVARHIYDHYIYPTSTGAF
                     QISYYPTEGTAWRAHKEMEEAYPLEIEQGRIKSGYLSLVPAHKKSSYRAWVFISKSVFL
                     "
     CDS             1484..2662
                     /locus_tag="ctg11_2"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFAYEFQKRGGKVLLIDQVFKHPEWS
                     RELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREYLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             2695..6246
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_3"
                     /sec_met_domain="PFOR_II (E-value: 5.4e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 6.2e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 6.2e-31, bitscore: 100.4,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.3e-11, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 2.1e-11, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 3.4e-08, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00017, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.1e-24, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMNPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKTKQHLVDIKSNVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARIVKLFNEILAADNASPEAKEVLKAWIENMYDADKTKE
                     LAPQVKAVIEEGLSHGCPICKELKGLTQYLVKRSQWIIGGDGASYDIGYGGLDHVIASG
                     KDVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQI
                     AMGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLW
                     RYNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAK
                     WRYNSYKRLARENWGAE"
     CDS             complement(6207..6356)
                     /locus_tag="ctg11_4"
                     /transl_table=11
                     /translation="MNSSGKKGVLFMLDRVHTIKNGNLLQDYRFLFIGYYYYSAPQFSL
                     AKRL"
     CDS             complement(6398..7264)
                     /locus_tag="ctg11_5"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAMLLLASCTNSDLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFFG
                     EVYGEARVGLVVPQYVTIHSINELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRLLVDSW
                     IPKSENK"
     CDS             complement(7285..8109)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.5; E-value: 8.7e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg11_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.4e-28, bitscore:
                     92.5, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMVHFSTFFDAVNAGIGSFIIGFQHILFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSPRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(8106..9332)
                     /locus_tag="ctg11_7"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTTGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDTDDKLVGEVRLNDLLKLRSKQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETREFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(9631..9969)
                     /locus_tag="ctg11_8"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMSQ
                     CSRMVGRALKQIPDDLSAPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             10053..11348
                     /locus_tag="ctg11_9"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLLGA
                     LAFSSCEKNLYDESKQPEKEKKMTDLEVPADFDWKGSQNAKVKIASQSTATISVFLEEN
                     CNEEALMLRMDVDANTSKLELPIEIPAYIKNVYVKYGNGSEIQTVPVESNGTISIVVPA
                     NATALSRVTTRANKEVETNNIFNYPGYGNGTIMFEDMYPALGDYDFNDFVAWYNFQIDG
                     FYWSHNQCYAEYLMIGFQIRAIGGIYDYNPYIRLAEVQYNELDLEETQMYLERNNPEEA
                     ENIKILKGPKGELIISLKKPAIPNGYKYYNTEVNEKTKPKKMMAIYLVFNSPVNVKSLQ
                     DSKMDFYIAKTNKGQEIHLKGYSPVYYNSNESYVNEDNFIWGLKVPASLHHAREEVNFL
                     EAYPDFEQWVTSGGQENQRWWNKPKTNKLIMN"
     CDS             complement(11490..14372)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 62.8; E-value: 1.2e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg11_10"
                     /sec_met_domain="Peripla_BP_1 (E-value: 1.9e-19, bitscore:
                     62.8, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEAMKYTKWITVLFCLLGLAACRQDAPRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDKGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNYPDIKLIDKADAAWEREPAEVEMDSMLRRHPKIDAVYAHNDRI
                     APGAYQAAKKAGREKEMIFVGIDALPGKGNGLELVLDNVLDATFIYPTNGDKVMQLAMN
                     ILEKKSYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRSKNRLNKELSEQKKQVEQQRDKLEEQRDILEEQRD
                     KLEEQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADSSLSEDQR
                     RMLLLVQRNVNILLRLVNQILDFRKYENGKMEYTPISLDILSSFEGWNESFMAVARKKH
                     IHFSFDYMPDTDYRTLADVEKLERIYFNLLSNAFKFTPENGKVTVRLSSLTKDDHCWIR
                     FTVANTGSMISAEHIRNIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTITVESDEKQG
                     TIFTVDLPVQTCETVVSENSPAFSVSATSVTSTDATTSAVAGVPATPATSGYSGSSSLN
                     DALTYEEEELEKSYDSSKPCVLIIDDNADIRLYVHGLLHTDYTVIEAADGSEGIRKAMK
                     YVPDLIISDVMMPGMDGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYI
                     SKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGD
                     SNLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGY
                     EVGFSSPSYFTKCYREQFGESPTDLLKRKG"
ORIGIN
        1 cacatggcat gtgattactt gtttcatgca atgaaacttt ttgtttctcg gtgtggaacc
       61 aatggtttca ctgcatgaaa ctatcagttt cacaccgaga aaccataact tcgatataat
      121 atcacaaaaa cacgcttttt gagataaaca cccacgcccg ataactactc tttttatgag
      181 ccggcaccaa tgacaaatag cctgatttta ttcttccttg ttctatttcc aaaggataag
      241 cctcctccat ttctttgtgt gctctccagg ctgttccttc cgtagggtaa tagcttattt
      301 gaaaagctcc tgttgaagta ggatagatat aatggtcata aatatgacgc gctactactc
      361 ccatattcat cctcaagttg atttccacgc aaggatgaat ccgataaaca ggagattctg
      421 gaaagcgaca gatcatcata tccactccca aataaccatt ataaatggtt ccgaaacgga
      481 gggataattc ttgttcaagg cggtcgcgca atttataaat ttcttcgaca gggatatatt
      541 ccgaaagatt ccgttcgatg gctgcatctg aaatcagcag attaccttcg tacgccccac
      601 ttccacccgt acggaattga gagtatccgg caaagccaaa tcgaccatta cccgaagaac
      661 gaaattccat agcaaaatct tccaccttat tatatagagg ttcgccaata acacctcctt
      721 gctggttgcc aatgcgtgag caccaaccgg aaatggaagg agtatataca cctttgcacc
      781 aattcaaccc ttttccgcta ccggataaag gagctttcag taaacaagta tcatgtgatt
      841 ctacaaatga cttccattct tcgggaaacg tcaggtaaaa agactctcca caaaaacagg
      901 ctcccagttg tagctgtggt aataatccca cagcgcagga acgatgggaa cagaaacgca
      961 gtttatccaa ttgctcaata gaaggaagct cgctttcttc cactcccaaa tccaacagtc
     1021 gttttcttat tgctatatcc cagccccaag gacgaatatc caaattccgc tccgaagcaa
     1081 gttcaggttc tgtcatcaaa tcaaccgaaa gtcctaataa ttcctgtatc ttcttcacat
     1141 agtcgagatt ataagcggaa ggagccaata caacacttcc ctcttctgca taccacatcg
     1201 gcaacaaagc caattcggat gccatctgcc gggcggaagc cggtgccata tagtttgttt
     1261 caccgctggc taacgccaaa tcatgttccg gattgaatat ataaagagcc ttttttgtca
     1321 ttttaaacga attcaataca ttattctgca aatatataca ggaaatagcc aggaatggct
     1381 acaataaaca gaaagttcta attaaactca caattttgcc atctctactt tgcaaatcct
     1441 aaaaaaagca gtatatttgc cacccgaaaa acaaagaact gaaatggaat cattctatcg
     1501 cacacacgcc tacctcgttg agcacaccaa tgcccccgtt cgccgcgatc ttatggacga
     1561 gatcgattgg agcgaccgcc tgattggtat caaagggaca cgtggcgtag gaaaaaccac
     1621 tttccttctc caatacgcca aagagaaatt cggaaacgac cgttcctgtc tgttcatcaa
     1681 catgaacaat ttctatttct cgggacacag cattgtagac tttgcctacg aattccagaa
     1741 acgtggcgga aaagtattgt tgattgacca agtgttcaaa catccggaat ggagcagaga
     1801 gttgcgcatg tgttacgatc gttttcctaa tctgaagatt gtctttaccg gctcatccgt
     1861 gatgcgactg aaagaggaaa accttgaact gcgtgatatt gcaaagagct ataacctgcg
     1921 cggattttct tttcgcgaat acctgaactt acagacaggc atgaaattca gggcatacag
     1981 cctcgaagaa attcttagca ctcacgaaca gattgccaaa ggagtactct ctaaagttcg
     2041 tccgctggat tacttccagg attacctgca tcatgggttc tatccgttct tcctcgagaa
     2101 gcgtaacttc tcggagaatt tgctgaaaac gatgaacatg atggtggaag tagatatcct
     2161 gctcatcaaa caaattgaac tgaaatatct ttcaaagata aaaaaattac tatatttgct
     2221 cgctgtcgac ggaccgaagg ctcccaatgt gagccaactg gcaagcgaca tacagacatc
     2281 tcgcgccacg gtgatgaact atatcaagta tctggcagat gcacgactga ttaatctggt
     2341 ttatccgaag ggggaagaat tccctaaaaa accttcgaag ataatgatgc acaactccaa
     2401 cctgatgtat tccatctacc cggtgaaagt ggaggagcag gatgtgctcg acactttctt
     2461 tgtgaattct ttatggaaag accataaggt acataaagga gataaaaacg tctcttttat
     2521 ggtggacgaa gtaatgccgt tcaaaatttg ccaggaagga gcaaagatca agaacaatcc
     2581 gaatgtgacg tacgcgttac ataaggctga aataggtcgg ggcaaccaga tacctctctg
     2641 gatgttcggc tttttatatt aaaagattta tttacttaaa tatttaattt agttatgact
     2701 aaacagaaga aattcatcac ttgtgatggt aaccaggctg cagcgcatat ctcgtatatg
     2761 ttttctgaag tagctgctat ctaccccatc actccttctt cgactatggc tgagtacgta
     2821 gacgaatggg ctgccgcagg acgtaagaac atcttcggcg aaacagtatt ggtacaggaa
     2881 atgcaatctg aaggtggtgc tgccggtgca gttcacggtt ctcttcaggc tggtgcgttg
     2941 actactactt acactgcttc tcaggggctt ctcctgatga tccctaatat gtacaaaatt
     3001 gccggtgagt tcttgccttg cgtattccat gtgtctgctc gtacattggc ttctcacgca
     3061 ttgtgtatct tcggtgacca ccaagacgta atgtcagctc gtcagactgg ctttgctatg
     3121 ttggctgaag gctctgtaca ggaagttatg gatttggctg gtgttgccca cttggctacc
     3181 atcaaatctc gcgttccgtt catgaacttc ttcgatggtt tccgtacatc tcacgaaatc
     3241 cagaagattg aaatgttgga aaatgatgat cttgctccgc tgatcgatca ggaagctttg
     3301 gctgaattcc gtgcccgcgc actgaatccg atgaatccgg ttgctcgtgg tatggctgaa
     3361 aaccccgacc acttcttcca acatcgtgaa tcatgtaaca actactatga agcagttcct
     3421 gctatcgtag aagaatacat gaatgaaatt tctaagatta caggtcgtaa atacggtttg
     3481 ttcgattatt atggtgcaga agatgcagaa cgcgtaatta tcgctatggg ttctgtaaca
     3541 gaagctgccc gcgaagctat cgaccacttg gtagcaaatg gcgaaaaagt gggtatggtt
     3601 gccgtacacc tgtatcgtcc gttctctgct aaacacttcc tggctgctgt acctaagact
     3661 gccaagacta tcgcagttct tgaccgtact aaagaaccag gcgctaacgg cgaacctctt
     3721 taccttgacg ttaaagactg cttctacggc gcagaaaatg ctccggttat cgttggcggt
     3781 cgctacggtt tgggttcaaa agatactact cctgctcaaa ttctttcagt attcgagaac
     3841 ttggccatgc caatgccgaa gaatcacttc actatcggta tcgtagacga cgttactttc
     3901 acttctcttc ctcaaaaaga agaaatcgct ttaggcggtg aaggaatgtt cgaagctaaa
     3961 ttctacggtt tgggtgctga cggtacagta ggtgctaaca agaactctgt aaagattatc
     4021 ggtgacaaca ctgacaaaca ctgccaggct tacttctctt atgactctaa gaagtcaggt
     4081 ggtttcactt gttctcactt gcgtttcggt gatactccga tccgttccac ttatttggta
     4141 aatactccga acttcgttgc ttgtcacgtt caggcttacc tgcacatgta cgatgtaact
     4201 cgtggtttgc gtaagaacgg ttctttcttg ctgaacacta tctgggaagg tgaagaactg
     4261 gctaagaacc tgcctaacaa ggttaagaaa tattttgcac agaacaacat ttccgtatac
     4321 tatatcaacg caacacagat tgcattggaa attggtttgg gtaatcgtac caacactatc
     4381 cttcaatctg cattcttccg tatcacaggt gttattcctg tagaccaggc tgttgaacag
     4441 atgaagaaat tcatcgttaa gtcttacggt aagaagggtg aagacgttgt taacaagaac
     4501 tatgctgccg ttgaccgtgg tggtgaatac aagactttag ctgttgatcc tgcttgggct
     4561 aacctgccgg atgatgcaaa agctgaaaac aacgatcctg cattcatcaa cgaagtagtt
     4621 cgtccgatca atgcacaaga tggtgacttg ctgcctgtat ctgcattcaa gggtatcgaa
     4681 gacggtactt ggtatcaagg tacttctaaa tacgaaaaac gtggtgtagc cgcattcgtt
     4741 cctgaatgga atccagaaaa ctgtatccag tgtaacaagt gtgcatacgt ttgtcctcac
     4801 gcttctatcc gtccgttcgt actcgatgct gaagagcaga agggtgctaa gttcgaacaa
     4861 ttgaaagcag taggtaaagt attcgacggt atgacattcc gtatccaggt tgacgttctc
     4921 gactgtctgg gttgcggtaa ctgtgctgac atctgtccgg gtaatccgaa gaagggtggc
     4981 aaagcattga caatgaaaca cctcgaaagc caattggctg aagctgacaa ctggacttac
     5041 tgtgctgaaa acgtgaagac taaacaacat cttgttgata tcaagtctaa cgtgaagaac
     5101 tcacagttcg ctactccgtt gtttgagttc tctggtgctt gctctggttg tggtgaaact
     5161 ccgtatgtga aattgatttc tcaattgttc ggtgaccgtg aaatggttgc taacgctacc
     5221 ggatgttctt ctatctactc tggttcagtt ccttctactc cgtatactac gaacgaaaac
     5281 ggtcacggtc ctgcttgggc taactcactg ttcgaagact tctgtgaatt cggtttgggt
     5341 atggaattgg ctaatgaaaa gatgcgtgct cgtatcgtga agttattcaa cgaaatcctt
     5401 gctgccgaca acgcttcacc tgaagcaaaa gaagtgctga aagcatggat tgaaaacatg
     5461 tacgatgctg acaagactaa agaattggct cctcaagtga aagcagtgat tgaagaaggt
     5521 ctttctcacg gatgtcctat ttgcaaagaa ctgaaaggac tgactcaata tcttgtaaaa
     5581 cgcagccagt ggatcattgg tggtgacggt gcttcttacg atatcggtta tggtggtctt
     5641 gaccatgtaa tcgcttccgg taaggacgtt aacatcctcg ttctggatac tgaagtttac
     5701 tctaacacag gtggtcagtc ttctaaggct actccggtag gtgctatcgc taagttcgct
     5761 gctgctggta agcgcgtacg taagaaagac ctcggtctga tggctactac ttacggttat
     5821 gtatatgttg cacagatcgc tatgggtgct gaccaagctc aaactctgaa agctatccgt
     5881 gaagctgaag catatccagg accatctttg attatcgctt acgctccatg tatcaaccac
     5941 ggtctgaaag caggtatggg taagagccag gaagaagaag aaaaggctgt taagtgcggt
     6001 tactggcact tgtggcgtta caacccggct ctggaagaag aaggcaagaa tccattccaa
     6061 ttggatagca aagaaccgaa ctgggaagat ttccaaggtt tcttgaaagg tgaagttcgt
     6121 tacgcttctg taatgaaaca atatcctgct gaagctgaag aactattcaa agctgccgaa
     6181 gaaaacgcta aatggcgtta caacagctac aaacgtttgg ctagagaaaa ctggggtgct
     6241 gaataatagt aataccctat aaataaaaaa cggtaatctt gtagaagatt accgtttttt
     6301 attgtatgaa ctctgtccaa cataaacagt actccctttt tcccactaga gttcatgtct
     6361 attttatatt taaaattaag aataacaatg ctccaatcta tttattctct gacttcggaa
     6421 tccaactatc caccaacagc cgatgctcat ccctccattt acgggctatt tcttcttcat
     6481 ccatcctggc atccttcata gctgtcataa aagagctaag ttcttctgtc gttagtttga
     6541 tgttgccaaa gaattcggca gcaaacggat ctttctcact gaatcctttc catgcaatag
     6601 catgtatttc ttccaagtct ccatatactt tcttcggatc atccaagaat ttcaagtcaa
     6661 actggtcgaa catccaatgc ggtgtccacc ccgtaatgac aatccattct cctttgtcca
     6721 tcgctttttt caaagaagcc agcatggtgg aactacttga agtcatgagg gtatacccat
     6781 caagtccgta agcagcaatg gccttatcgg tcgtcttcat tatccctgct cccgcatcaa
     6841 ttcctactat ttcagaagaa aaacggtctt tattagcttc cagctcatta atagagtgga
     6901 tcgtaacata ttgaggaaca accagtccga cgcgagcttc tccgtatacc tccccaaaaa
     6961 attcgatgct gtctccatac tgatccatat aatctttcat cgttattggt aaccaggcat
     7021 ccagaaacac atcagatttc tttcctgaca tagatacaaa gatgggggca aggtcagcat
     7081 tttgcagttc aacctcatat ccatgctctt ccaataccac cttagccaaa tgactcatgg
     7141 caataccttc cagccaattg gcataggcta tttttacttt ctttttctct aagtctgaat
     7201 tagtacagga agctagcaaa agcatagctg acaatactat tcctactatt ttatatattc
     7261 tcatacgtat tttatccttt ccgtttagtt cttatttttt cgtcctgcca ttccttgcgt
     7321 gatacggtct aagatgatag ctaaaataac aactgctata ccaccttcaa acccaagtcc
     7381 gattttcatt tgggtaatac ctttcaatac aatttctccc agaccaccgg cagcaatcat
     7441 ggcagcaatg acaaccatag aaagcgacat cattattgtc tggttgacac cagtcagaat
     7501 ggtgggcaac gccaaaggaa gctgcacttt atacaataac tgccaacggg tagctccgaa
     7561 cgaacgggaa gcttccacta catttttagg aacttgccgg attcccaatc cggtaaggcg
     7621 gaccacagga ggcatagcaa agataatggt ggcaaacact cctggcactg ctcccaatcc
     7681 gaaaaacaaa acagcaggaa tcagataaac aaaagcaggc atcgtctgca tcaagtcgag
     7741 aacaggacga agtattttct ctgcacgcgg actgtttgcc gtccacactc ctaaaggtac
     7801 accaacaatc agagccagac aggtagatga aaaaacgaga gccagggttt gcatagtagc
     7861 ctcccaaaat cccattccat agatcagtaa taatcccaat gcggtgaaaa ttgccgtacc
     7921 gcgtcctgct ttcatccatg cgagtgcagc aagtaccaaa atggttatat aaaaaggtat
     7981 tccgaaaagt atgtgttgga atcctataat aaaactaccg atgcccgcat tcacggcatc
     8041 aaagaaagtg gaaaaatgta ccatcatcca attgatggcc atctctatat attgtcctat
     8101 atttatcata aatctattgc gttttgaatt atttcgttta tttcttcttt atctttcccg
     8161 gtcacttcga tgattaagga tgaaagcggg attgttccta aaaactcgcg cgtctcatca
     8221 atcacccata ccggtgaatt gctctttgtc attagaggaa gtatatcctc caacaccgta
     8281 tcctccaaca cagaatgtac ttctgtacgc acaatcgttt caatggattt ttcctgtttg
     8341 ctacgtaact taagcaagtc gttcagacgt acttctccga ccagtttatc atcggtgtct
     8401 atgacaggta atacggtgat attcttcgca cgcatcttac gaatcaatac ttcgggacct
     8461 tctttcttca gacgggccac caacggtttg tcaatcatta aagaagaggc ggtaataatt
     8521 ttgctcctat ccacgttttc aacaaaacgg gctacataat cgttagccgg ttcagtcagg
     8581 atttcctccg aagtacctac ctgcaccact tctccgtctt tcatgatggc aatacggtca
     8641 cctagcttaa ttgcttcact caagtcgtgg gtaataaaaa caatcgtctt tttcatcttt
     8701 gattgcaagg ccagtagttc atcctgcatc tgtacgcgaa tcagaggatc gagagcagag
     8761 aaagcctcat ccattaaaag cacttcagga ttattagcca gagcgcgagc cagtccgaca
     8821 cgctgttgca ttccaccgga aagctcgcct accatctgat tttcatatcc tttcaatccg
     8881 acaagcttca tgctttccat tgctttcttc tcacgttcct ctttcttcac tccctgaagt
     8941 tcgaggccga acgcgatatt gctcaatacg gaacggtgag gtaacagacc gaaattctgg
     9001 aaaaccatcg ccagctcttt ccgacgaacc tgcaataatt ctttttcgga aattttagat
     9061 atatctactc cgtttacaag cacttgcccg gtagtaggac gtatcagacg attgatacaa
     9121 cgcagtaatg tcgattttcc acttcccgag agtcccatta tcacgaaaaa ctctccttca
     9181 ttaattgaaa gattggcatc tttcactcct accgtacaac cggtatcttt cagaatttcc
     9241 tctttactct tatctttttt caacatcttg agggctttct gcttctcgtt accaaagata
     9301 aggtacaaat cctttatttc tattttactc atataatata ttggtttaga ttataatatt
     9361 tgttttgttt tcaactgccg cattccttat tctcacttac gataaacaag ttgaatgttc
     9421 gcatggttca gtcatgtcac atgataacat gacggtccga cgttttttaa atggtttaaa
     9481 aaaacagaca gagtagttta aaaggaatag aatttgataa gattatcctc ttaatgaaca
     9541 gtagaaaaca gtattttcat aaataaataa cagtctgttc ttgcatattg ttggcacaaa
     9601 ggtaaggaaa atagattaaa tatgcaaatt tcattcaggt acggagtaat tccaaagatg
     9661 ctttttcaag tctacgcatc cattttgttt gaaagagatc ccttcttcca acaagagttg
     9721 tttctgctct gtccaacccg gaacaagccg tcccgacgca ttgacaaccc gatgacaagg
     9781 cgcagataaa tcatccggaa tctgtttcaa agcacgcccc accatacggg aacattgaga
     9841 cattcccaat aatgcggcaa ttcccccata ggtagaaact ttacctaccg gaatttctcg
     9901 gacaacctga tacacctctt gacaaaagga tgcggaaagg ctcgccttat ctactttata
     9961 atctttcatc actcaaacat tactttattt cagttccaaa actagataaa aagaaaagaa
    10021 tttgcaaata ataaaagcat ttcaaataaa atatgcaact ttatttgctt tatttacaaa
    10081 taatcccgac ctttgtaccc attaaaagca accctattat taacaaaaca agcactgctg
    10141 ttatgaaaaa gaaaactatc ctgttcgctt cttgtttatt gggagcactg gctttcagct
    10201 cctgtgagaa gaacctttat gatgaaagta aacaacccga gaaagaaaag aaaatgactg
    10261 acttggaagt acctgccgat ttcgactgga aaggttctca aaatgccaaa gtgaaaattg
    10321 ccagtcaatc aactgctact atttctgtat ttctagaaga aaattgcaat gaagaggctt
    10381 tgatgcttcg aatggatgtc gatgccaaca catcaaaatt ggaactccca attgaaattc
    10441 ctgcatatat aaaaaatgtg tatgtaaaat atggtaatgg ctctgaaata caaactgttc
    10501 ctgttgaaag taatggtact atttctatag tagtacctgc taacgctacg gcattatcca
    10561 gagttaccac aagagctaat aaagaagttg aaacgaacaa catcttcaat tatccgggat
    10621 atggcaacgg aactattatg ttcgaagata tgtatccagc tttaggcgat tatgatttta
    10681 atgattttgt tgcatggtat aatttccaaa ttgacggttt ttattggagt cacaatcaat
    10741 gttatgcaga atacttaatg ataggattcc aaatcagagc tataggaggt atatatgact
    10801 acaatcctta tatccgcttg gcagaagtac aatataatga acttgattta gaagaaactc
    10861 aaatgtatct tgagcgtaac aatcctgaag aggctgaaaa tatcaaaatc ctaaaaggcc
    10921 caaaagggga attgattatt tcactaaaga aaccggccat tcctaacgga tacaagtatt
    10981 ataatacgga ggtaaatgaa aaaacaaagc ctaaaaaaat gatggccatt tacttggtgt
    11041 tcaactcacc tgttaacgtt aaaagcctac aagacagtaa aatggacttt tatattgcaa
    11101 aaactaataa aggacaagaa atccacttaa aaggttatag cccggtttat tataacagca
    11161 acgaaagtta tgtaaatgaa gacaacttta tatggggatt aaaagtacct gcatctttac
    11221 atcatgccag agaagaagta aacttcttgg aagcatatcc agactttgaa caatgggtaa
    11281 catcgggagg tcaagagaac caaagatggt ggaataagcc aaaaacgaat aagttgatta
    11341 tgaattaata aatatacagt aaatcatata ctgaattaaa taagaggtaa ggtatgtcaa
    11401 tagatttcct tacctcttat ttttatcata tgaattccat agaagtataa acagataaat
    11461 gctcaccacc aaattttgca gattctatcc tatcctttcc tcttcaacaa atctgtcgga
    11521 ctctctccaa actgttctct ataacattta gtaaaataag aaggagaact aaaaccaact
    11581 tcataaccta tctctgccac tgtcatatcc gacgaagcaa gcagggaagc agctttcttc
    11641 aaacgagcta tacgaagcag ttcattcggg gaataattag ttagggattt gattttgcga
    11701 tagagttgca cacggcttaa tcccatatct ttacccaagt cttccacatt caaatttgaa
    11761 tctcccatct ttgcctcaat caaagctttg aatttttcca caaagtcttt atccatatca
    11821 cagacatcct ctttcgccaa cgtttgtccg tcaccaaaaa actgtttcag gcggcggtgt
    11881 gaatctatca gattacgaac gcgtgccaat agtaattgcg aactgaaagg cttggagata
    11941 taagaatctg caccaccatc atacccttga attcgttgtt catccaaaga acaagctgtc
    12001 aataggataa caggaatatg acaggtttgt aattcgcttt tcaagcgacg acaacattca
    12061 attccatcca ttccgggcat cattacatcg gagataatca agtccgggac atatttcata
    12121 gctttacgaa taccttccga gccgtctgca gcttctataa cagtataatc agtatgaagc
    12181 aatccatgca catataagcg aatatcagcg ttatcatcaa taatcagaac gcaaggtttg
    12241 gaagagtcgt aacttttttc caattcctct tcttcgtaag ttaaagcatc attcaagctc
    12301 gaagaaccgg aataaccgga agttgcagga gttgccggaa ccccagcaac ggcagaggtt
    12361 gtagcatcgg tggaggttac agaagtagca gacacagaga atgccggaga gttttcagaa
    12421 acaacagtct cgcaagtctg cacaggcaaa tcaacggtaa agatagttcc ttgcttttca
    12481 tcactttcca ccgtgatggt acctttatgc aattccacaa aagcctttac caatgccagt
    12541 ccaatacccg aaccggcatg gtgcatatct atcttataga aacggtcgaa aatattccgg
    12601 atatgctccg cagaaatcat tgaaccggta ttggcaacgg taaagcgaat ccagcaatga
    12661 tcgtctttag tcagggaaga caagcgtaca gttacttttc cgttttccgg agtaaatttg
    12721 aaagcgttgg aaaggaggtt gaaatagatg cgttccaact tttctacatc tgccaatgtg
    12781 cggtaatccg tatccggcat ataatcgaat gagaaatgaa tatgcttctt ccgggctact
    12841 gccatgaaag attcgttcca tccttcaaaa gaagaaagaa tgtctaacga aataggagta
    12901 tattccattt ttccattctc gtatttacga aaatccagaa tctgattgac aagacgcaaa
    12961 aggatattca cgtttcgctg aactaacaat aacattcggc gctgatcttc actcaaagac
    13021 gaatcagcca gtaaatgctc taccgggtcg gcaactaatg tcagtggagt acgaaaatcg
    13081 tgagatatat ttgtgaagaa aaccagcttg gcatgagtcg cttcttccag ttgatgagaa
    13141 agctggataa gctgatcccg ctgttcttcg agtttgtcac gctgttcttc aagaatatcc
    13201 cgttgctctt cgagtttatc gcgctgttgc tctacttgtt tcttctgttc ggacaactct
    13261 ttattcaggc gattcttgga acggagggat ttatagacta ccaacaacaa tcccgctact
    13321 aataaaagaa taaccaagcc gccatacatc acgacctgct gcgtagctac acgcgacaga
    13381 tacccaccga tacgtccgtt caatgtttca atcttctgat ccagttccga gatatgggta
    13441 gtctgaagtt gcataacgtg cgcgttcgtg cggtctacaa cggcagtatt catgaccgtt
    13501 tcgcgaggat aagacttctt ctcaagaata ttcatggcca gttgcatcac tttgtcccca
    13561 ttagtcggat aaataaaagt tgcatccagc acattgtcaa gcaccaattc aagcccgttt
    13621 cctttgccgg gcagggcatc aatgccaaca aaaatcattt ccttttcacg tccggctttc
    13681 ttcgcagctt gataggctcc cggagcgata cggtcgttat gtgcatatac cgcatcaatc
    13741 ttcggatgac ggcgaagcat actatccatt tccacttctg ccggttcacg ttcccaggca
    13801 gcatccgctt tatcaatcag tttgatatcc ggataattgc tgatagcagc cataaatccc
    13861 tgatggcgtt ccatggcagg ggtggaacca cccagtccgg taagctccac tacattccct
    13921 ttccctttca gacttgatgc gatataattt cctaccgcac gacctatttc ataattatcg
    13981 gcaccgatat aggcagtata tttatcagaa agtatcttcc ggtctacaag aatgacaggt
    14041 attcctttct gataggcctc ctccacaatt ggagtcatgg gagccgcttc attggcggaa
    14101 attatcagta aatcaactcc tttatctata aaataatgaa catcttccgc ctgcttacgg
    14161 ttatcatccg ccgccgagcg gatttcaacc gacactccat cataaaacat cgcttcgcga
    14221 agaatctcat cattcatctt gtgcctccaa gagtcatcgc tacattgggc caccccaata
    14281 cggaaacgag gcgcatcctg ccgacaggcc gccaagccca aaagacaaaa caagactgtt
    14341 atccacttcg tatatttcat cgcttcaatc attccctttc tttcgtatat cttttgtatt
    14401 tctttctgta atccaaattt ctctccccgc attatttgca ttcaccaccg ggaaatacat
    14461 cagttccact ttcacagggt tcagcgtata ttttccagta aagcgtggaa gcaaaggaac
    14521 cgtaaactga taagtaccta ccggtaattt ttcgctaaag ataacagttt tctctttaaa
    14581 atactcacga tatacttcag aacgggagaa attaacaggt tttgaggcat aactacaacc
    14641 tgccggaaca ggaacttcga gcatcacata ttgcgcaccc tcctgtttca cctgcaaggt
    14701 aactgtcaat gtaacaggta cacccgccac caaagagtct ttttccaaag tcacctccac
    14761 cttgaaagca tcactctgac gagcattcat cacacgcttc attgaataga cactatacaa
    14821 taaaggctct tttcccgttt ttgaaataag cagactgtcg cctgctgtca gccgggcatg
    14881 ataaggaaat tccgtaattc gttgatgatc cttaccgctc acagacaccg acgttcctga
    14941 catccctcca gaacctgcca gcaaatcggt cagaacagtt gccacagccg aagaagcctg
    15001 atacgtattc catccgcgct ccttagtccg caaaatatac aattgcatat tttctttcaa
    15061 cttacacagg gaagggtcat ttttaataat ccggtaggct atcaatgtat ttatcatctg
    15121 atttccctcc caataataag tacgccgtcc gtcgtcacag taaacacctt ccagcatatc
    15181 ctttttcaga taaggacgta cgctatcacc cacattcacc gaatccacct gttgcttgat
    15241 ttcccagaga agcagcttct ctttcaagta tgaaagagga cgataatact tgtttctatt
    15301 tgccaacgag tcttctttct gttccaattg ccggacgaaa ggttccaata atctgactgc
    15361 cgaagaataa tccgcctcta ctttccactc atgcagagca tgaagtattt ctatatcttc
    15421 cagtttcatt cctcgataag gacgcgtatg agcatactcc actttcaaac cattcagatt
    15481 caactccaca ggataacctg catcttgcgc catcttcaaa gcccgcagaa tatgcgcaga
    15541 catccagaaa gaagtatttt cagagttccc ccaccacgac cataactgat gtttgttctg
    15601 atgattcgtc agtcgatgga tgataggtcg aattgcttta tctactttca ccttttcacc
    15661 cttactctgc atatactgtt ggtaagccaa caaaccgatt aacttggatg ccagctgctc
    15721 attgcacaaa tatttgtatc ctgtcaagta attcactgat tctttataga tgtccaactg
    15781 attgtcagtg atactcacca tcacttcttc atcctcgccg gattgcactt taaccgtctt
    15841 tgcatcggac agaataccca atgtgccctc cgccaattca gttccctgtg ccagtatcgg
    15901 aatcgtatat tcctctccat cctgatagcc atcgtcgcga gtgaaaagat agctgatggt
    15961 cacgctatcg gcatgaactg cctgcatcgg cactgtttca tgaaatccct ccatgaaact
    16021 cacttcctgc cgtttcaacg tatccgttcc gacgcagaac tgtgtctttc cggctatgtg
    16081 ctgcccatcc agataattgc ggatagtccc gaccaccgta ctctgatccc cctccaccaa
    16141 gaagcgggga gttttcaact ccgccatcaa cggtttgtaa gagcggatgg aacgtcggaa
    16201 agtacccgtc tgcaaacgac ggttcatgcc ataaacgaca gtttcc
//
