LOCUS       c00036_gnlPro..        15808 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AOPGDALD_82.
ACCESSION   c00036_gnlPro..
VERSION     c00036_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 09:53:49
            Original ID  :: gnl|Prokka|AOPGDALD_82
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15808
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15808
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1251:5808]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1252..5808
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15808
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15808
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             78..1076
                     /locus_tag="ctg36_1"
                     /transl_table=11
                     /translation="MPLKLTTYYHGKDIPELPGKNTFHSKELFLIYEATPGYTPLLIVA
                     TEDGRPVARLLAAIRKAKKWLPSSLVKHCVVYSEGEFLDESLSTNKEKAEEVFGDMLEH
                     LTQEASRSCVLIEFRNLNNSMFGYRVFRANDYFPVNWLRVRNSLHSMKKTEDRFSPSRM
                     RQIKKGLKNGARVEEAHTVEEIHDFSRMLHKVYSSRIRRYFPANDFFRHMNDMLIKGQQ
                     AKIFVVKYKEKIIGGSVCIYSGDDAYLWFSGGMRKTYALQYPGVLAVWKALEDAHQRGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRVNWSWLNKLLVKFYV"
     CDS             1252..1656
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_2"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1e-23, bitscore:
                     75.1, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAEGKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             1685..3238
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_3"
                     /sec_met_domain="CT_Btheta (E-value: 6.2e-290, bitscore:
                     952.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYVFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGFELIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPT
                     KPYDMYEVIGAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             3270..4190
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_4"
                     /sec_met_domain="OAD_gamma (E-value: 2.1e-15, bitscore:
                     48.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLVLNEILIDNQNNFQD
                     DYGLHSAWIEIFNKSFGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWIGLFDSGRKLLDQIVVPAGVLGPNQSYARVSDGAAEW
                     EVKGGSGDKYVTPSTNNKTLDSNAKMEKFEEHDADGVGMSISAMSVVFCGLILLFIAFK
                     IVGKVAVNLSKRNAMKSKGIDKHEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRETPPRK"
     CDS             4215..4646
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.7; E-value:
                     2e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_5"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.2e-21, bitscore:
                     67.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKPA
                     AKPVTVRPMPNAPTAPTQVVKPTAPSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVNKGDSVLEGNDLVIIE"
     CDS             4648..5808
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_6"
                     /sec_met_domain="OAD_beta (E-value: 8.2e-153, bitscore:
                     499.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATVGHVVMILVGLGFIYLAVAK
                     EFEPMLLIPIGFGMLIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKNERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFIIATASGVIFVKIFNIFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDSTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             6103..7443
                     /locus_tag="ctg36_7"
                     /transl_table=11
                     /translation="MKRIIILFFLCCTIPLIAQHTDPIQEAMANYDYETALSLIAQKKT
                     TPPLLLQKGKALRGLGLTTEALATYQEIICNDTTNTRAFIEAAECCRALAKYNQALKYY
                     EHALDLNPENKYVRIQYISLLLSQQKFSEALGESSLMTEKDSSAIVLHLQAQSFEGMGE
                     LLPAAGCYYNIQAKYPDDYLAASKLGALNISGSYFDEAIEATEKYRQIDSTNISVNRQN
                     ALAYCLKQDYPTAIQRYEYLVSQGDSSFHTCYYLGISYYAAEKYYEAHDFLEVARKYDP
                     NNINLLYYLGRACSKTSWKKEGVDYLEKAIDLSIPKDSSMTRLYIGMTDCYKMAQMYKE
                     QIASIKERYQRYDKQNHKLLYDMAYIYFYDLKDKKNAERYLEAFLKTRPKDTKEEAEMN
                     ERGELVLGKSNYYNAAANWLKDIQSKQKIEDFFQNSSPQLPLPKKDK"
     CDS             complement(7528..8532)
                     /locus_tag="ctg36_8"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTREMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCAHPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSSDHHT
                     YTDPEEVIDFATRTGCDSLAISIGTSHGAYKFTPEQCHIDPKTGRMVPPPLAFEVLDAV
                     MEKLPGFPIVLHGSSSVPEEEVETINKYGGALKAAIGIPEEELRKAAKSAVCKINIDSD
                     SRLAMTAAIRKVFAEKPAEFDPRKYLGPARDNMEKLYKHKILNVLGSDNKLAQ"
     CDS             8969..9223
                     /locus_tag="ctg36_9"
                     /transl_table=11
                     /translation="MKKGLHPESYRPVVFKDMSNGDMFLSRSTVATKETIEFEGETYPL
                     LKIEISNTSHPFYTGKSTLVDTAGRVDKFMSRYGDRKKK"
     CDS             complement(9304..10518)
                     /locus_tag="ctg36_10"
                     /transl_table=11
                     /translation="MINREQYMEQIVPFIDKPFVKVITGIRRSGKSVVLRLIRDELLRR
                     GVREERIIYLNFESFQWIDLKEAKALYAYIRGQAGDAGKYYILLDEIQEVDGWEKVVNS
                     LLVDLDTDIYVTGSNSRMLSSELATYLTGRYVAFHVMTLSFREYLTFHDLQANDPTLNR
                     KEEFQKYLRMGGFPAIHTADYGYEAIYKIVYDIYSSVILRDTVQRHNIRNVELLERVVK
                     FVFDNIGNKLNAKNIADYFKSQQRKVDMNTIYNYLNALESAFIIQRISRYDIKGKEILQ
                     TNEKYFVSDLSLIYSVMGYRDRLIAGMLENLVCLELKRRGYEVYVGKQDDKEVDFVAIR
                     REEKIYVQVTYQLASQATVEREFAPLLAINDHYPKYVVSMDSLWQDNVEGVRHRHIADF
                     LLDDA"
     CDS             10736..11119
                     /locus_tag="ctg36_11"
                     /transl_table=11
                     /translation="MTKEEVFNFIRQRLSFSKELQEQFRHVNKDDLAKEHRRFEMSGNE
                     SKTGQCTIFNTAILNEFADLGIYDYTSYLFLDFHNGTPTVYLKYFSENENLEYTFTGYT
                     TTEIIFAILELTIFSGKPKRNRS"
     CDS             11855..12286
                     /locus_tag="ctg36_12"
                     /transl_table=11
                     /translation="MPKWISVEKAVIKYHIEKEAILLWVEMGQFPMLYIDNVPNVDEEC
                     ILELFRRSKAGITAEYIDTLEQLCIDKTMVCEKYAHIIQLKEKEIQLQKEINTLINEIQ
                     AAMKRQNERIRDLKKAIGENNNVIRSDSWIKRLRKRFQW"
     CDS             13372..14427
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg36_13"
                     /sec_met_domain="Biotin_lipoyl_2 (E-value: 1.3e-12,
                     bitscore: 38.7, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKNFGFVLAAAILLAGCGQKKETTTTTARPVKTTIVESRSIIRK
                     DFSGIVEAVEYVKLAFQVNGQIIQLPVIEGQKVKKGQLIAAIDPRDIALQYAATKSAYE
                     TASAQVERNKRLLSRQAISVQEYEISLANFQKAKSEYELSANNMRDTKLTAPFDGSIEK
                     RLVENYQRVNSGEGIVQLVNTHNLRIKFTIPDAYLYLLRAKDPRFLVEFDTFKGHVFQA
                     KLEEYLDISTDGTGIPVSITIDDPSFDRDLYAVKPGFTCSIRFTADVGPLVQDSWTIVP
                     LSAVFGESEGNKMYVWVVEDNKVHKREVTVNAPTGEAQALISEGLKPGEKIVIAGVYQL
                     VEGESITTVDR"
ORIGIN
        1 actttacttc aagcagctcc aacaaattct ttattttgtt gttgaataaa gaataaaaag
       61 tgtaaatttg tacctagatg ccactgaaac taacaacata ttatcatggg aaggatattc
      121 ctgaattgcc gggaaaaaat accttccatt ccaaagagtt atttctgatt tatgaagcaa
      181 ctcctgggta tactccttta ttaatagtgg caacagaaga cggcagaccg gtggcacgcc
      241 tgcttgctgc catccgcaaa gcaaagaagt ggctcccttc ttctttagtg aaacattgtg
      301 tagtatatag tgaaggcgaa tttctggacg agtctctttc gaccaacaaa gaaaaggcag
      361 aagaagtctt cggcgatatg ctcgaacatc tcacacaaga agcatcgcgc agctgtgtcc
      421 tgatcgaatt ccggaacctg aacaattcga tgttcggcta tcgggttttc cgtgccaatg
      481 attatttccc tgtcaattgg ttgcgggtac gcaattcgct gcacagtatg aaaaagacgg
      541 aagaccggtt cagtccgtcg cgtatgcgtc agataaaaaa aggactcaag aatggagcca
      601 gagtagagga agcacatacc gtggaagaga tacacgattt ctcacggatg ctgcacaagg
      661 tttattcctc ccgcatacgc agatatttcc ctgccaacga ctttttccgc cacatgaacg
      721 atatgttaat caaaggacaa caggcaaaaa tattcgttgt gaaatacaaa gagaaaatca
      781 ttggcggttc tgtctgtatc tattcgggag acgacgcata cctttggttt tcgggaggaa
      841 tgagaaagac atacgcactt caatatccgg gtgtgctagc tgtttggaaa gcattggaag
      901 acgcacacca acggggattc cgccacatgg aatttatgga tgtaggactt ccgttccgta
      961 aacacggtta tcgtgatttc gttcttcgct tcggaggaaa acaaagcagt acccgccgtt
     1021 ggttccgcgt caattggagt tggctgaata aactcttagt caagttttat gtctaaatgt
     1081 aatctcaaga ttacaaaaca atgttttatg ctcctttccc accatttttt ctgtttaata
     1141 atccaataat taaatgcaga aatatttctt tattagataa gaaatgtctt tctttgtgct
     1201 gttttatgcc ttataagcac agatttaaaa ccaaataaaa aaagtatagt tatgaagatt
     1261 tcacacattg aacatctggg cattgctgta aaaagcatcg aagaagccct tccttactac
     1321 gaaaatgtat taggtctgaa gtgttacaac attgaaacag tggaagatca gaaagtaaga
     1381 actgcttttt taaaagtggg cgaaacaaaa attgaactgt tggagcctac ttgcccggag
     1441 agtactattg ccaaattcat tgaaaacaaa ggtgcaggcg ttcaccacgt cgcatttgct
     1501 gtagaagatg gcgtagccaa tgcgctggca gaggcagaag gcaaagaaat ccgccttatc
     1561 gacaaagctc cccgcaaagg tgctgaaggt ttgaatatcg ctttccttca cccgaaatca
     1621 actttgggtg tgttaacaga actctgcgaa cattaatcat aaactctaaa accaacaaga
     1681 actcatgagt aatcaacttg aaaaaattaa agagcttatt gaacgccgtg ccgtagcacg
     1741 tatcggaggc ggtgaaaaag caattgcgaa gcaacacgaa aaagggaaat acacagcacg
     1801 cgagcgtctg gctatgctgc ttgacgaggg tagcttcgaa gaaatggaca tgttcgttga
     1861 gcacagatgc acgaacttcg gcatggagaa aaaacattac ccgggagacg gtgtagtaac
     1921 cggctgcggt acgatcgaag gacgtctggt atatgtgttc gcacaagact tcactgtttc
     1981 tgccggttca ctgtcagaaa cgatgtcatt gaaaatttgt aaaatcatgg atcaagccat
     2041 gaagatgggc gctccctgta tcggtatcaa cgactcgggt ggtgcacgta ttcaggaagg
     2101 tatcaacgct ttggcaggtt atgcagaaat cttccaacgc aatatccttg cttccggtgt
     2161 tatcccacag atttcaggta tcttcggtcc ttgtgccggc ggtgctgttt attctccggc
     2221 tctgaccgac ttcacgctaa tgatggaagg tacttcttat atgttcctta ccggaccaaa
     2281 agttgtgaag accgtaacag gtgaagacgt tagccaggaa aacctcggtg gcgcaagcgt
     2341 tcactccact aaatcaggtg tgactcattt caccgctaaa acagaagaag aaggtttcga
     2401 actgattcgt aaactgttga gttatattcc tcaaaacaac cttgaagaag ctccttatgt
     2461 agattgtaca gacccaatcg accgtctgga agattctttg aatgatatta tccccgacag
     2521 ccctactaaa ccgtatgaca tgtacgaagt tatcggcgct attgtggaca acggtgagtt
     2581 ccttgaaatc cagaaagatt atgcaaagaa tatcatcatt ggtttcgccc gtttcaacgg
     2641 acaatcggta ggtattgttg ccaatcagcc taagtatctg gctggtgtgc tcgacagcaa
     2701 cgcatctcgc aagggtgcac gtttcgtgcg tttctgcgat gcattcaata ttcctatcgt
     2761 atcgttagta gacgtaccgg gattccttcc gggaacaggt caggaataca acggcgttat
     2821 ccttcatggt gctaagctat tgtatgctta cggtgaagct actgtgccta aggttactat
     2881 cacattgcgt aaatcttacg gtggttctca catcgtaatg agctgtaagc aacttcgcgg
     2941 tgacatgaac tacgcatggc cgactgctga aatcgcagta atgggtggag caggagcagt
     3001 agaagtattg tacgcacgcg aagccaaaga tcaggaaaat cccgctcaat tccttgctga
     3061 aaaagaagca gaatacacga aactgtttgc caatccttac aatgcagcca aatacggcta
     3121 catcgatgat gtgattgaac cacgcaacac acgtttccgc gtaatccgtg ctttgcagca
     3181 gttgcagact aagaaattga gtaatccggc taagaagcat ggtaatattc cgttgtaatc
     3241 ctacttttca cattaaaaca agaacgatta tgaacaaaac caaaatcgga atattccttt
     3301 ctttgctgtt gctgattggg ctgacttctt gtggagagca aaagtcgaac aacaagctgg
     3361 tactgaacga aatcctgata gacaatcaga ataattttca agatgactac ggattgcaca
     3421 gcgcatggat tgaaatattc aataaatcat tcggtagcgc cgacctggca gcttgcttgt
     3481 tgaaagtaag cagccaaccg ggcgatacag ttacttactt tatcccgaaa ggtgatatac
     3541 ttacattagt gaagccacgt caacatgcac tattctgggc agatggcgaa cctaaccgcg
     3601 gtactttcca caccagcttc aagctgaatc cggaaacggc caactggatc ggtctgtttg
     3661 actccggtag aaagctgctc gaccagattg tagtgcccgc aggtgttctt ggccccaacc
     3721 agtcatacgc tcgtgtcagc gacggagcag cggagtggga ggtaaaaggt ggaagtggtg
     3781 acaaatacgt gaccccgagt acgaacaaca aaactcttga cagcaatgcc aagatggaaa
     3841 aattcgaaga gcatgatgct gacggtgtcg gcatgtccat ctctgccatg agtgtagtat
     3901 tctgcggatt gattcttctc tttattgcct tcaagattgt aggaaaagta gctgtaaatt
     3961 tgagcaagcg caatgctatg aaatctaaag gcattgacaa gcatgaagct aaggaactgt
     4021 cacaggctcc gggcgaagtt tacgctgcga tttctatggc attgcacgaa atgcaggatg
     4081 aagtgcacga cgtagaagaa acggtactga ccatcactcg cgtaaaacgc agttactcac
     4141 catggagttc gaagatttac actttgcgtg aaactcctcc cagaaagtaa gtcacctttt
     4201 aaaaagttaa aacgatgaaa gaatataaat ataaaatcaa cggtaactca tataaagtaa
     4261 ccatcggaga tattgaagat aatatcgctc atgtagaagt gaacggtaca cactataaag
     4321 tggaaatgga gaaacagccg aagcctgctg ccaaacctgt aacagtacgt cctatgccta
     4381 atgctcctac tgctcctact caggtagtga aaccgactgc tccgtctacc ggaaaatcag
     4441 gagtgaaatc tccgctgccg ggtgttatcc tcgacatcaa agtgaatgta ggcgatactg
     4501 taaagaaagg acagaccatt atcatattgg aagccatgaa gatggaaaac aatatcaatg
     4561 cggataagga cggtaagatt actgccatca acgtcaacaa gggagactct gttcttgaag
     4621 gtaatgacct cgtaattatt gaataatatg ggagatttta taaacttttt aggaaataac
     4681 ctcgccgact tctggacata cacgggcttt gcaaatgcta ctgtagggca tgtcgttatg
     4741 attcttgtgg gtttggggtt catctatctg gcggtagcca aagagttcga accgatgctg
     4801 ctgattccta tcggcttcgg tatgctgatc ggtaatatac cttttaatat ggatgccgga
     4861 ctgaaagtcg gtatttatga agaaggttcc gtattgaata tattgtatca gggagtaact
     4921 tccggctggt atccgccgct catctttttg ggcatcggcg ccatgacgga cttctcggca
     4981 cttatctcta atccgaaatt gatgttgatc ggtgctgctg cacaattcgg tatcttcggt
     5041 gcttacatga tcgcattgga aatgggcttc gacccgatgc aagccggcgc tatcggtatc
     5101 attggtggag cagatggccc gacggccatc ttcctttctt ccaagctagc acctaacctg
     5161 atgggagcca ttgcggtgtc cgcctactcc tatatggcgt tggttccggt gatacagccg
     5221 cctatcatgc gtctgctcac caccaagaac gaacgtgtca tccgcatgaa accgccgcgt
     5281 gccgtttctc acacggagaa ggttattttc ccgattatcg gcttgttgct gacctgcttc
     5341 ctggttcctt ccggtctacc tttgttgggt atgctgttct tcggtaacct gttgaaagaa
     5401 agtggtgtaa cccgtcgtct tgccaataca gctagcggtc cgttgattga tactatcact
     5461 atcctgttgg gtctgacagt aggtgcttct acgcaagctt ccgaattcct gacgctcgat
     5521 tctatcaaga ttttcgccct cggtgcattg tcattcatca ttgcaactgc atccggtgta
     5581 atcttcgtta agatattcaa tatcttcttg aagaagggca acaagatcaa tccattgatc
     5641 ggtaatgcag gggtttctgc tgtccccgac tctgcacgta tctcacaagt gattggtttg
     5701 gaatacgatt cgaccaacta tttgttgatg cacgctatgg gtccgaacgt tgccggagtg
     5761 atcggttcag ctgttgctgc cggtatcctg ctcggattct tgatgtaaga tataaggagg
     5821 ctgtttgaac agttcttaaa ataaaaaata agactatcct aaaagccttg aatttataaa
     5881 aatcaccttt gctacattat agtagtaaag gtgatttttc attataagga cttgctgtaa
     5941 aaaagactgt agctaccatg ccccatgtat tgtattgcgc actgttgtgt taccttctct
     6001 tatcattccg ttaatctatc caaaataatc tacgaataat tcgtaaatat aatattttta
     6061 gtaacttgca gcagataagt caaacaacta aaataaaata ttatgaaacg gattatcatt
     6121 ctgttctttc tttgttgtac cattcctcta atagcgcaac acacagaccc tattcaagaa
     6181 gctatggcaa actacgatta tgagacggcc ctttctctta tagctcaaaa aaagactacc
     6241 cctcccctgc tattacagaa aggcaaagcg ttgcgtggac taggactcac cacagaggca
     6301 cttgctacct atcaagaaat tatctgtaat gatactacaa atactcgtgc tttcattgaa
     6361 gcggccgaat gttgccgagc actagctaaa tacaatcaag cactaaaata ttatgaacat
     6421 gcacttgatc tgaatccgga aaacaaatat gtacgtattc aatatatcag cttgcttctc
     6481 tcccaacaga agtttagcga ggcgcttggt gaaagtagtc tgatgacaga aaaagacagt
     6541 tccgccattg tcctgcatct acaagctcaa agctttgaag gaatgggcga acttcttccc
     6601 gctgcaggtt gctattacaa tatccaggct aaatatcccg acgattatct ggctgccagc
     6661 aaactaggcg ctctaaatat atccggttcc tatttcgacg aagccatcga agctacagaa
     6721 aaataccggc aaattgacag taccaacatt tccgtcaacc ggcagaacgc tttagcatac
     6781 tgcttgaaac aagactaccc cactgccatc caacgttatg aatatcttgt cagccaagga
     6841 gacagttctt ttcatacttg ttattattta ggcatcagtt actatgcagc agagaagtac
     6901 tacgaagctc atgatttttt ggaagtcgcc cgtaaatatg atcccaacaa tatcaatctc
     6961 ctttattacc tcggtcgcgc ctgttccaaa acttcctgga aaaaagaggg cgtagactat
     7021 ctggaaaaag ccattgatct atccattccc aaagatagca gtatgactcg actttacatc
     7081 gggatgaccg actgttacaa gatggcacaa atgtacaaag aacagattgc atccatcaaa
     7141 gaacgctacc agcggtatga caaacaaaac cacaaactat tgtatgacat ggcctatata
     7201 tacttctatg acttgaaaga taagaaaaat gcggaacgct atttggaagc attcctaaaa
     7261 acacgtccta aagacactaa agaagaagcg gaaatgaacg agagaggcga acttgtttta
     7321 ggaaaatcca attattataa tgccgccgcc aactggctga aagatattca aagtaaacaa
     7381 aaaatagaag acttctttca aaattcctct ccacaacttc ctctcccaaa gaaagataaa
     7441 tagataagaa ctataaagca actaaaaggc tgctaccggt ttatcggtag cagcctttct
     7501 tttatttatg gaataatccg gagattatta ctgtgccaat ttgttgtcag aaccgagcac
     7561 attcagaatt ttgtgcttgt acagtttttc catattgtca cgagccgggc caagatactt
     7621 acgtgggtcg aattcagccg gtttttcagc gaatacctta cgtatagcag cagtcatagc
     7681 cagacgagag tcagagtcga tgttgatttt gcaaacagca gacttagcag ctttacgcaa
     7741 ttcttcttcc ggaatgccga tagcagcttt cagtgcacca ccatatttgt tgatagtttc
     7801 cacttcttct tccggaactg aagatgatcc gtgaagaacg atagggaatc ccggaagttt
     7861 ttccattaca gcgtccaata cttcgaaagc caatggagga ggaaccatac ggccagtctt
     7921 cgggtcgatg tggcattgtt ccggagtaaa tttgtaagca ccgtgagaag taccgattga
     7981 gatagccaaa gagtcgcaac cagtgcgagt agcgaagtcg attacttctt cagggtcagt
     8041 atatgtgtga tggtcggaag aaacttcatc ttctacacca gccaatacgc caagttcacc
     8101 ttctacagtt acgtcaaact ggtgagcgta ttcaacaact ttcttagtca atgctacgtt
     8161 ttcttcgtaa ggaagatgag aaccgtcaat catcactgaa gagaaacctg aatcgataca
     8221 agatttgcaa gtttcgaatg tatctccgtg gtcaagatga agaacgattt ccggatgtgc
     8281 gcagcctaat tctttagcat attctacagc accctgtgcc atgtaacgca acaaagtagc
     8341 gttagcatac tgacgagcac ctttagaaac ctgaagaatc acaggagatt tagtttcaac
     8401 agcagccttg atgatagcct gcatttgttc catattgttg aagttgaatg ctgggatagc
     8461 atatccacct ttgatagcct tagcaaacat ttctcttgtg tttaccaatc ctaaatcttt
     8521 gtaatttacc attttgttta aagtttattg ttagtgaata aaaattctac gcaaaagtaa
     8581 gcattatcca tcgaataacg aacatcggaa agaaaaatat agtagaaaaa ggtttaaatc
     8641 agactgcaaa atttagcagg aatacgagtg tgacattaga ttgtaatgtc caccttgcaa
     8701 actttgggat ttatgatttc tgaattctga ttgatgcctt cggatttata tctccttatt
     8761 tataccttat ttttcattca tttgatcacc aaaatctgca tagccaatca gaaatcagaa
     8821 attataaatc agaaattata aatcagaaat tttagaaaac ctttttctat ttcacagaaa
     8881 agcattatct ttgcgctctg aaaatgacca ttacactatt tcttaccaaa atagtaacag
     8941 aatataaatt aaaaaaacag atactgaaat gaaaaaaggc cttcatccag aatcataccg
     9001 tccggtagta tttaaagata tgtcaaatgg tgacatgttt ttgtctagat caactgtagc
     9061 aactaaagaa accatcgaat tcgaaggtga aacttatccg ttgctgaaga ttgaaatctc
     9121 aaacacttct cacccgttct atacaggtaa atctacattg gtagatactg caggtcgtgt
     9181 tgacaagttc atgagccgtt acggtgaccg taagaagaaa taattcgatc tttcgtgaaa
     9241 gatgaaaaaa gaggagattc tcgcagagaa tttcctcttt ttcgttttct atattcctta
     9301 acgtcaagca tcatccaaca agaaatcggc tatatgacga tgcctgacac cctccacatt
     9361 atcctgccac aagctgtcca tgctaactac atatttagga taatggtcgt taatggcgag
     9421 caaaggagca aactccctct caacagttgc ctgtgaagct aactgatacg ttacttgcac
     9481 ataaatcttt tcttcccgac ggatggctac aaaatccact tctttatcat cctgtttgcc
     9541 tacatacact tcataacccc ttcttttcaa ctccagacag accagattct ccaacatacc
     9601 tgcaatcaac cggtcacgat agcccatcac ggaataaatc aaagaaaggt cgcttacaaa
     9661 atacttctca ttcgtctgca gaatttcctt tcctttaata tcataccggg aaatacgttg
     9721 aatgataaaa gcactttcca atgcattcag ataattatag atggtattca tatccacctt
     9781 ccgttgctga cttttgaagt aatcggctat atttttagcg ttcagcttat tgcctatatt
     9841 atcgaaaaca aacttcacta cccgttcgag cagttccaca ttccggatat tgtgacgctg
     9901 caccgtgtca cgaagaatga cagaagaata gatgtcgtag acaattttat agatagcctc
     9961 atatccataa tcggcagtat gtatggccgg aaatcctccc atacggagat atttctgaaa
    10021 ttcctccttc cggttgagcg tcggatcatt ggcctgcaag tcatggaaag tcagatattc
    10081 tctaaaagac aaggtcatga catggaaagc gacataccgt cccgttaaat aagttgccag
    10141 ttcggacgat aacatacgtg agttggagcc ggtcacataa atatccgtat ccaaatctac
    10201 cagaagtgag ttgaccactt tttcccaacc gtccacttcc tgaatttcat ccaagagaat
    10261 ataatattta cccgcatctc ctgcctgccc ccgaatataa gcatacaaag ccttcgcctc
    10321 tttcagatct atccactgaa aactttcaaa attcagatag atgatacgtt cttcacgaac
    10381 tcctctcctc aacagttcgt cacgaatcag acgcagcact accgactttc cactgcgacg
    10441 aatacccgtt atcactttta caaacggctt atctataaaa ggaacaattt gttccatata
    10501 ctgttcacga ttaatcatat tcaaaagttt ttagggttat aagcacaaag atatactatt
    10561 ttcggaaagt ttttagggtt ataagcataa ataaatccat aaattcagat tcttttaggg
    10621 ttataagccg aaaaataaat aaaagaaata tgactgaatc cgatttatta ccaaataaag
    10681 aaagtacctt taccccaata attaataaaa aatggaaata accgatttaa aacaaatgac
    10741 aaaggaagaa gtttttaatt tcatcagaca acgcctttct ttcagtaaag aactgcaaga
    10801 acaattcaga catgtgaata aagacgatct cgcaaaagaa catcgcagat tcgaaatgtc
    10861 cggaaatgaa tcaaagacag gccaatgcac gattttcaac acagcgattc tgaacgagtt
    10921 tgccgatctt ggcatctatg attatacttc ttaccttttt ctcgacttcc acaatggcac
    10981 tccaaccgtt tatctcaaat atttctccga aaatgaaaat ttggaatata catttaccgg
    11041 atataccaca acggaaatca tctttgcaat tcttgaactg actatcttct ccggaaagcc
    11101 caaaagaaat cgcagctaaa aaaaagaatt gcacggaaag acaatgcgag gtcaaaagac
    11161 ttttatggct ttcatttagg cacggattac acggatttca cggttccatt agactaaaag
    11221 ccgcgaaatc cgtgtaatcc gtacctaaat aatatcaatc taatagatgg tttcactttt
    11281 ggctccctcc tttttatcat cacattatat ttgccacccg tatagcatat ttaccatctt
    11341 tataccatac tctctattct cataccatat ttcctgcatt tatttcctct tttccatcct
    11401 attccgaaaa aaacatatat ctttgtcaca cgctttctgc ccatcagcgt gatgaaacag
    11461 gcaaaagcgg tttttattcc ttaatggagt aaataacgta ttgtctctca aacttaaaaa
    11521 ttagcagttt tttcacaccg agagatgata caacagatac tccacgtaga tagtcgtata
    11581 tcaacatatc gattagagat ttgttatata taaacgtttg gcgtgggtgt ctgttgttta
    11641 tcattatctg gtgaagggta ttgctaagcc ttaagtttag ataatggtac aacagcactc
    11701 acgcttttat tgtatccggt cggtttcaac aatccttata ccccaaccaa ttccccaccc
    11761 gaccgaaatc ataaaaatcg tgggtgttcg ttgcacctct ccggacaata cattatttac
    11821 tccttttttt ataacacatt aaaacaaaag caatatgcca aaatggatta gtgtagaaaa
    11881 agcagtgatt aagtatcaca tcgaaaaaga agcgatcctg ctttgggtgg aaatgggaca
    11941 atttcctatg ttatacatag acaatgttcc gaacgttgac gaagaatgta ttctggaact
    12001 ctttcgccga agtaaagccg gcattacagc agaatatatt gatacactgg aacaactgtg
    12061 catagataaa acaatggtct gcgagaaata cgcccacatt attcaattga aagaaaagga
    12121 aattcagctg cagaaggaaa taaatacgtt gataaacgaa atacaggcag caatgaagag
    12181 acaaaatgaa cggatccggg atttgaaaaa agcgattgga gagaataaca acgttatacg
    12241 tagtgacagt tggataaaaa ggctgcgcaa aaggtttcaa tggtgaataa ttatcagcgt
    12301 accaattacc atgtgggaca caacgtaaac aattagcata ttggcacatt attgcacggt
    12361 ttttaccaca gaggacacag aggtgaattt ggtttatgac ttacgcttgt gaccctaatt
    12421 ttgatgcgta atcctcctct ataaagttga aaaaacatga aaacatctgc cacctgcaac
    12481 caaacgcgtg taatgcacta gttgataaat agttagagcg ttgcagatac ctgcggcaga
    12541 taggttgcag ataaagtatc tgcaacacag tataaacctt acataagcta attctccagg
    12601 agggcaaaag tttattgtat acataaactt cccgtttcca ggcggggaac tgtcgtttcc
    12661 ggcattagaa attacaattt ccacggcagg aaacgaaagt ttctaagacg ggacactaca
    12721 gtttccacgt aaggatactg tcgtttcccc gtagagacac caccatttct ccatagagtc
    12781 accccaatta tcccatagct ttgcacaaag gaatcaaggc tttttctttg attatataac
    12841 gtgttgcaga tactttatct gcaacctatc tgccacaggt atctgcaacg ttccaactat
    12901 ttattaacta gtgtattaca cgcttttcgt tgcaggtggc agatgttttt atgtttttca
    12961 actttatagt aggaaaaaat ttcattcatt tctgcaccgt ttcattcatt tttgcactga
    13021 aatgagcaaa atagtgcgat tttagtttat ttctgcacac ttctttgcta aatgggaatt
    13081 tatatttcac tacagaggac acggaggaca cagaggttaa ctatttttta ttcactatag
    13141 agtaatacag agtaatcgta tttatcgctc tgttttgctt acggaaagag agagaagaac
    13201 tctgtgtcct ctgtggtgaa ctcgtaaagt tcccgttttt tttgtgttcc atataaaggt
    13261 taagaggcag gatatgaaaa gacaggaatg ttgaacataa ataaacagga gttgttttag
    13321 tatattattc gctatttatc aacgcaaaac ctctaaacat caacgtggta tatgaaaaag
    13381 aattttggat tcgtcctggc ggctgcaatc ttgcttgctg gctgcggaca gaaaaaagaa
    13441 acgacaacga caactgcacg tcccgtaaag actacgattg tcgagtcaag atcgattatc
    13501 agaaaagatt tctcgggaat cgtggaagcg gtggaatatg tgaagctggc tttccaagtc
    13561 aacggacaaa tcatccagct tcctgtcatc gaaggacaga aagtgaaaaa aggacaactc
    13621 atcgcggcta tcgaccccag agacattgcg ttgcaatatg ccgctacgaa atcggcatac
    13681 gaaacggctt cggcacaagt ggaacgtaac aaacggctcc tctcccggca agcgatctcc
    13741 gtgcaggaat atgaaatcag cctcgccaac ttccagaagg cgaaatctga atacgaactg
    13801 tctgccaaca atatgcgcga caccaagctg acagctcctt tcgacggttc tatcgaaaaa
    13861 cgactggtgg aaaactatca gcgtgtcaac tccggtgagg ggatcgtgca gcttgtcaat
    13921 acacacaatc tgcgtatcaa attcaccatt ccggatgcgt atctttattt gttgcgtgcc
    13981 aaagacccgc gtttccttgt agagttcgac acatttaaag gacacgtgtt tcaagcgaaa
    14041 ctggaagaat atcttgatat ttctacggat ggcacaggaa ttccggtcag catcacgatt
    14101 gacgatccgt cattcgaccg cgatctgtat gctgtgaaac ccggtttcac gtgcagcatc
    14161 cgtttcacgg cagatgtagg tccgttggtg caggatagct ggacgatcgt accgcttagt
    14221 gccgtattcg gtgaaagcga agggaataaa atgtatgtct gggtggtaga agacaacaaa
    14281 gtccacaaac gggaagtgac cgtcaacgcc ccgaccggag aagcacaggc gctcatctcg
    14341 gaaggtttga aacccggtga aaaaatcgtc atagcaggcg tataccaact agtagaagga
    14401 gaatctatca caactgttga caggtgatag ttggtaaatg attaagtatc atttatccgc
    14461 tgtcattcat caattatcaa cgatcattta ttatgagttt agccaaatat tcattagata
    14521 atacgaaaat catctatttc tttcttgctg tattgctgat tgggggaatc acttccttcg
    14581 gcaagctggg taagaaagag gatgctcctt tcgtcataaa gtcggcggtt attatgaccc
    14641 gctatccggg tgccgaaccg gcagaagtgg agcggttgat taccgagcct atctctcgtg
    14701 aaattcaaag tatgagcggt gtgtacaaga taaaatcaga atcgatgtac gggctctcaa
    14761 aaatcacatt cgagttgcaa ccttccttgt cggcaagctc cattccgcag aagtgggatg
    14821 agttgcgacg gaaggtgcta aatatacagc cacaattgcc gagcggtgct tccgcaccga
    14881 cggtttccga tgatttcggc gacgtgttcg gtatctatta cggtttgacg gcggacgacg
    14941 gttacacata cgaagagatg cgcaactggg cggaacggat caagacgcag gtagtgacgg
    15001 cagacggggt gatgaaagtc gccctgttcg ggacgcagac ggaggtggtc aatattttta
    15061 tttccaccaa taagctcgta ggtatgggca tcgacccgaa acagcttgcc agtctgttgc
    15121 aatcgcagaa ccagattatc aataccggag aaatccgtgc cggcgagcaa cagctccggg
    15181 tgaccgccaa cggtatgtat accaccgtag acgatatccg caaccaggtg attaccacca
    15241 aagccggaca ggtgaaactg ggcgatatcg ccgtcatcga aaaagggtac atggaccctc
    15301 catccaatat catgcacgtg aacggcaaac gtgccatcgg catcggcgtc tccaccgacc
    15361 cgcaacggga cgtggtgcaa acgggcaaga acgtgaaagc caaactggac gaattgttgc
    15421 cactgatgcc tgtgggactg gaactgcaaa gcctgtatct ggagaacgaa attgccaacg
    15481 aagccaacaa cggatttatc atcaatctga tcgaatcgat tctgattgta attgtgatta
    15541 tcatgttggt gatgggtttg cgcgcaggtg tgctgatcgg ctcgtcactg attttctcta
    15601 ttggcggcac attacttatc atgtctttct tcggtgtcgg actgaaccgt acatcattgg
    15661 cgggatttat catcgccatg gggatgctgg tggataacgc catcgtggta acggacaatg
    15721 cacagattgc catcgcccgc ggagtagacc ggcggaaagc gctgatagac ggcgcaaccg
    15781 gtccgcaatg gggattgctt ggggctac
//
