LOCUS       c00012_gnlPro..        14585 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CCCDCJJA_54.
ACCESSION   c00012_gnlPro..
VERSION     c00012_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 05:42:24
            Original ID  :: gnl|Prokka|CCCDCJJA_54
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14585
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14585
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[28:4585]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      29..4585
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14585
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14585
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(29..1189)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_1"
                     /sec_met_domain="OAD_beta (E-value: 2.1e-152, bitscore:
                     499.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATVGHVVMILVGLGFIYLAVAK
                     EFEPMLLIPIGFGMLIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKNERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFIIATASGVIFVKIFNIFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDSTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(1191..1622)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.7; E-value:
                     2e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_2"
                     /sec_met_domain="Biotin_lipoyl (E-value: 3.1e-21, bitscore:
                     67.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKPA
                     AKPVTVRPMPNAPTAPTQVVKPTAPSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVNKGDSVLEGNDLVIIE"
     CDS             complement(1647..2567)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_3"
                     /sec_met_domain="OAD_gamma (E-value: 5.3e-15, bitscore:
                     48.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLVLNEILIDNQNNFQD
                     DYGLHSAWIEIFNKSFGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWIGLFDSGRKLLDQIVVPAGVLGPNQSYARVSDGAAEW
                     EVKGGSGDKYVTPSTNNKTLDSNAKMEKFEEHDADGVGMSISAMSVVFCGLILLFIAFK
                     IVGKVAVNLSKRNAMKSKGIDKHEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRETPPRK"
     CDS             complement(2599..4152)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_4"
                     /sec_met_domain="CT_Btheta (E-value: 1.6e-289, bitscore:
                     952.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYVFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGFELIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPT
                     KPYDMYEVIGAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             complement(4181..4585)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_5"
                     /sec_met_domain="Glyoxalase_4 (E-value: 2.5e-23, bitscore:
                     75.1, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAEGKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             complement(4761..5759)
                     /locus_tag="ctg12_6"
                     /transl_table=11
                     /translation="MPLKLTTYYHGKDIPELPGKNTFHSKELFLIYEATPGYTPLLIVA
                     TEDGRPVARLLAAIRKAKKWLPSSLVKHCVVYSEGEFLDESLSTNKEKAEEVFGDMLEH
                     LTQEASRSCVLIEFRNLNNSMFGYRVFRANDYFPVNWLRVRNSLHSMKKTEDRFSPSRM
                     RQIKKGLKNGARVEEAHTVEEIHDFSRMLHKVYSSRIRRYFPANDFFRHMNDMLIKGQQ
                     AKIFVVKYKEKIIGGSVCIYSGDDAYLWFSGGMRKTYALQYPGVLAVWKALEDAHQRGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRVNWSWLNKLLVKFYV"
     CDS             5999..9238
                     /locus_tag="ctg12_7"
                     /transl_table=11
                     /translation="MRCNAFVEAWKNHHRRASMILGLSLLSAPLSYSVYAEDGVSNTMV
                     QVVTQTKTVKGTIIDESGEPLIGVSIVVKGTSTGTITDFNGNFSINLPAGRKELVISYI
                     GYKEQTVTVTGNGPVNVKMVSDTQALDEVVVVGYGTMKKRDLTGAITSVKSEDVVMNPS
                     SNPMQALQGKVAGLDITRESGQAGSGVKMQLRGNRSFQKDSGNPLFIIDGMPGDYSTLN
                     PNDIESIEVLKDASSTAIYGSSGANGVILITTKGGKEGKAIVNFNAYVGVNGWSRTPEM
                     RSGESYIQTLRDASVGAGDGRWSSVADDKNLFTTDAEWNAHQNGQYIDWVDALLKTSVT
                     QNYSVSVAGGTENTKAYFSLNFSNEDGQFAQDSYKLYSSKIRVDHKIKKWMKVGIDAQL
                     SYVHQNKADSDLQTLMASNPLGSLYNEDGSINPQPVADPSSTVYNYLLNEDKSLYRNQA
                     QNLKVYYNPYLEITPLKGLTFITRAGANLGYSRSNTFTGEGSVQWYKANQTADGIKAQV
                     KDNRSYNYKWENILTYNFQIKKVHDITLTAVTSWNHNRSDVTTLYQKGVSDNKFLWHNI
                     LDGNSATSGSTSYSMSKGMGYVGRLNYSYMGRYLFAASVRHDGSSRLAEGNKWDTFPAF
                     SLGWRISDEKFMESTTNWLSNLKIRFGYGVTGSTAGIDPYSSAASLDATAVNMILGGVL
                     TPIYKFSQNIPNYLLTWEKSYNTNIGIDAAFLNNRIDVSMEYYNTKTKDVIWNKALPVI
                     NGAFSPDGGPKANYTTNLNMCETSNKGFELALNTRNIITKNFTWSSSVTFNHNKEKITK
                     LSGGDSDVLNNGDTGYALALGEAINSYYHYKLDGVWQKGEETDAAVFGAAPGDLKINIP
                     NLVKESDGRFYKIDEETGSAAVDENGNVIYYTSDNKYTPSDADYQILGHNSPDWSLGFQ
                     NNFTWKDFDLSVFVYARYGQMFAYDMLTSYDPKGIRNFPTYFNYWTENNPSNDFPAANA
                     NKGLEQYTGYYALRYVDGSFIKIKNITLGYSLPKSILKSAGIEKCRFYATITNPFVFAK
                     SHLLKDYDPEMNGSLKYPLTKQFVFGVNVTF"
     CDS             9263..11287
                     /locus_tag="ctg12_8"
                     /transl_table=11
                     /translation="MKSTIYKIAALTFAVASMSACSLDEYNPSQKTGDEILATFDGLKG
                     LQSYCYSSLYGQLFSVYDFLSVAEGGTDCWITPAGNPDYAKQVIYYDGLATNTNATNKL
                     FGQAYSMIGNCNAVVNRAELLTDGNEKDITTLVAEARCLRAFYYSILVNTYGNVTLTLE
                     ESSQDPILTPQRNSIEELYTQIIDDLKFAANNLEDTPYDSNRARVTKKTALGLLARVYA
                     QGGGEYGLTEDGVSYWQRAKEVAEDMILAYGDCLYDDVEDVWAPANNRNNKEALFIAAG
                     PDATNLENWNAGTQCNNNFTYMYPKPNTLTIYPTPDNQNYWYGRTNNNTLAPSKYLLDC
                     FDADYDKRWEVTFTTAFVQFSAVQSGGSYLFTNKKQTLDDGTKPKIGTKHGVNDNISSF
                     TILTQNIIDTYGLDAKFHNEYIYPYGDLNYTYYDGTWAPKMIAKVWPKGENSGDPSKLQ
                     EVKNPYVIPYPVAEDDDRICFYLSKERLSDAEKAKRRYYVINIDDLFDNGQYRKTDIKV
                     TNDKNMYPGFNKYNWLSEDSYSSNLQRKTGDVFIMRMAEVYLIAAEANQQLGNGGKAAE
                     YLNVLKKRAARNDASYNAMKLSNATQNDVMDEYARELCGEYQRWVLMKRHKDSFKQRLA
                     VGNPRAAENFDENKHYLRPISFNFLSQIDNAEEYGNNGY"
     CDS             11394..11936
                     /locus_tag="ctg12_9"
                     /transl_table=11
                     /translation="MLEEILAYNKQFVENKGYESYITNKYPDKKIAILSCMDTRLTALL
                     PAALGIKNGDVKMIKNAGGVISHPFGSVIRSLLVAIFELGVEEIMVIAHSDCGACHMHS
                     EVMLEKMKARGINPDYIDMMRFCGVDFHSWLDGFEDTEKSVRGTVDFIVRHPLIPSDVT
                     VYGFIIDSTTGELTRIV"
     CDS             12372..12908
                     /locus_tag="ctg12_10"
                     /transl_table=11
                     /translation="MENFSELIKNRRSMRKFTDEELTQDQVVALMKAALMSPSSKRSNS
                     WQFVVVDDKEVLKELSHCKEQASSFIADAALAIVVMADPLASDVWIEDASIASIMIQLQ
                     AEDLGLGSCWVQVRERFTATGMPSDEFVHGILDIPLQLQILSVIAIGHKGMERKPFNEE
                     HLQWEKIHINKFGGK"
     CDS             12911..13246
                     /locus_tag="ctg12_11"
                     /transl_table=11
                     /translation="MGAAKANNSKDTYLATAVTFIVIGALYLIDKLIHFSSIGLPWVMN
                     KDNMLLYASICFLIFKRDKSIGFVLLGLWLVMNIGLVMSLLGSLSGYLLPLTLLIIGIV
                     LFWFAKR"
     CDS             13254..14048
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_12"
                     /sec_met_domain="F420_oxidored (E-value: 2e-13, bitscore:
                     43.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPIVFIGAGNLATNLAKALYRKGFRIVQVYSRTMESAR
                     TLAEKVEAEYTTDLQAVSKDAKLYIVSLKDDALVDLLPQITEGKQASLLVHTAGSIPMS
                     VWEGHAERYGVFYPMQTFSKQREVKFQEVPFFVEAKRPEDVELLKAVAATLSEKVYEAS
                     SEQRKSLHLAAVFICNFTNHMYALAADLLEKYNLPFDVMLPLIDETARKVHELAPRDAQ
                     TGPAVRYDENVMSNHLAMLVDSPALQEIYKLMSKSIHEHHQL"
     CDS             14029..14550
                     /locus_tag="ctg12_13"
                     /transl_table=11
                     /translation="MSTINYDLSRIKALAFDVDGVLSSTTVPLHPSGEPMRTVNIKDGY
                     AIQLAVKKGLHIAIITGGRTEAVRIRFEGLGVKDLYMGSAVKIHDYRAFRDKYGLTDDE
                     ILYMGDDVPDIEVMCECGLPCCPKDAVPEVKSVAKYISYADGGRGCGRDVVEQVLKAHG
                     LWMVEDAFGW"
ORIGIN
        1 agaactgttc aaacagcctc cttatatctt acatcaagaa tccgagcagg ataccggcag
       61 caacagctga accgatcact ccggcaacgt tcggacccat agcgtgcatc aacaaatagt
      121 tggtcgaatc gtattccaaa ccaatcactt gtgagatacg tgcagagtcg gggacagcag
      181 aaacccctgc attaccgatc aatggattga tcttgttgcc cttcttcaag aagatattga
      241 atatcttaac gaagattaca ccggatgcag ttgcaatgat gaatgacaat gcaccgaggg
      301 cgaaaatctt gatagaatcg agcgtcagga attcggaagc ttgcgtagaa gcacctactg
      361 tcagacccaa caggatagtg atagtatcaa tcaacggacc gctagctgta ttggcaagac
      421 gacgggttac accactttct ttcaacaggt taccgaagaa cagcataccc aacaaaggta
      481 gaccggaagg aaccaggaag caggtcagca acaagccgat aatcgggaaa ataaccttct
      541 ccgtgtgaga aacggcacgc ggcggtttca tgcggatgac acgttcgttc ttggtggtga
      601 gcagacgcat gataggcggc tgtatcaccg gaaccaacgc catataggag taggcggaca
      661 ccgcaatggc tcccatcagg ttaggtgcta gcttggaaga aaggaagatg gccgtcgggc
      721 catctgctcc accaatgata ccgatagcgc cggcttgcat cgggtcgaag cccatttcca
      781 atgcgatcat gtaagcaccg aagataccga attgtgcagc agcaccgatc aacatcaatt
      841 tcggattaga gataagtgcc gagaagtccg tcatggcgcc gatgcccaaa aagatgagcg
      901 gcggatacca gccggaagtt actccctgat acaatatatt caatacggaa ccttcttcat
      961 aaataccgac tttcagtccg gcatccatat taaaaggtat attaccgatc agcataccga
     1021 agccgatagg aatcagcagc atcggttcga actctttggc taccgccaga tagatgaacc
     1081 ccaaacccac aagaatcata acgacatgcc ctacagtagc atttgcaaag cccgtgtatg
     1141 tccagaagtc ggcgaggtta tttcctaaaa agtttataaa atctcccata ttattcaata
     1201 attacgaggt cattaccttc aagaacagag tctcccttgt tgacgttgat ggcagtaatc
     1261 ttaccgtcct tatccgcatt gatattgttt tccatcttca tggcttccaa tatgataatg
     1321 gtctgtcctt tctttacagt atcgcctaca ttcactttga tgtcgaggat aacacccggc
     1381 agcggagatt tcactcctga ttttccggta gacggagcag tcggtttcac tacctgagta
     1441 ggagcagtag gagcattagg cataggacgt actgttacag gtttggcagc aggcttcggc
     1501 tgtttctcca tttccacttt atagtgtgta ccgttcactt ctacatgagc gatattatct
     1561 tcaatatctc cgatggttac tttatatgag ttaccgttga ttttatattt atattctttc
     1621 atcgttttaa ctttttaaaa ggtgacttac tttctgggag gagtttcacg caaagtgtaa
     1681 atcttcgaac tccatggtga gtaactgcgt tttacgcgag tgatggtcag taccgtttct
     1741 tctacgtcgt gcacttcatc ctgcatttcg tgcaatgcca tagaaatcgc agcgtaaact
     1801 tcgcccggag cctgtgacag ttccttagct tcatgcttgt caatgccttt agatttcata
     1861 gcattgcgct tgctcaaatt tacagctact tttcctacaa tcttgaaggc aataaagaga
     1921 agaatcaatc cgcagaatac tacactcatg gcagagatgg acatgccgac accgtcagca
     1981 tcatgctctt cgaatttttc catcttggca ttgctgtcaa gagttttgtt gttcgtactc
     2041 ggggtcacgt atttgtcacc acttccacct tttacctccc actccgctgc tccgtcgctg
     2101 acacgagcgt atgactggtt ggggccaaga acacctgcgg gcactacaat ctggtcgagc
     2161 agctttctac cggagtcaaa cagaccgatc cagttggccg tttccggatt cagcttgaag
     2221 ctggtgtgga aagtaccgcg gttaggttcg ccatctgccc agaatagtgc atgttgacgt
     2281 ggcttcacta atgtaagtat atcacctttc gggataaagt aagtaactgt atcgcccggt
     2341 tggctgctta ctttcaacaa gcaagctgcc aggtcggcgc taccgaatga tttattgaat
     2401 atttcaatcc atgcgctgtg caatccgtag tcatcttgaa aattattctg attgtctatc
     2461 aggatttcgt tcagtaccag cttgttgttc gacttttgct ctccacaaga agtcagccca
     2521 atcagcaaca gcaaagaaag gaatattccg attttggttt tgttcataat cgttcttgtt
     2581 ttaatgtgaa aagtaggatt acaacggaat attaccatgc ttcttagccg gattactcaa
     2641 tttcttagtc tgcaactgct gcaaagcacg gattacgcgg aaacgtgtgt tgcgtggttc
     2701 aatcacatca tcgatgtagc cgtatttggc tgcattgtaa ggattggcaa acagtttcgt
     2761 gtattctgct tctttttcag caaggaattg agcgggattt tcctgatctt tggcttcgcg
     2821 tgcgtacaat acttctactg ctcctgctcc acccattact gcgatttcag cagtcggcca
     2881 tgcgtagttc atgtcaccgc gaagttgctt acagctcatt acgatgtgag aaccaccgta
     2941 agatttacgc aatgtgatag taaccttagg cacagtagct tcaccgtaag catacaatag
     3001 cttagcacca tgaaggataa cgccgttgta ttcctgacct gttcccggaa ggaatcccgg
     3061 tacgtctact aacgatacga taggaatatt gaatgcatcg cagaaacgca cgaaacgtgc
     3121 acccttgcga gatgcgttgc tgtcgagcac accagccaga tacttaggct gattggcaac
     3181 aatacctacc gattgtccgt tgaaacgggc gaaaccaatg atgatattct ttgcataatc
     3241 tttctggatt tcaaggaact caccgttgtc cacaatagcg ccgataactt cgtacatgtc
     3301 atacggttta gtagggctgt cggggataat atcattcaaa gaatcttcca gacggtcgat
     3361 tgggtctgta caatctacat aaggagcttc ttcaaggttg ttttgaggaa tataactcaa
     3421 cagtttacga atcagttcga aaccttcttc ttctgtttta gcggtgaaat gagtcacacc
     3481 tgatttagtg gagtgaacgc ttgcgccacc gaggttttcc tggctaacgt cttcacctgt
     3541 tacggtcttc acaacttttg gtccggtaag gaacatataa gaagtacctt ccatcattag
     3601 cgtgaagtcg gtcagagccg gagaataaac agcaccgccg gcacaaggac cgaagatacc
     3661 tgaaatctgt gggataacac cggaagcaag gatattgcgt tggaagattt ctgcataacc
     3721 tgccaaagcg ttgatacctt cctgaatacg tgcaccaccc gagtcgttga taccgataca
     3781 gggagcgccc atcttcatgg cttgatccat gattttacaa attttcaatg acatcgtttc
     3841 tgacagtgaa ccggcagaaa cagtgaagtc ttgtgcgaac acatatacca gacgtccttc
     3901 gatcgtaccg cagccggtta ctacaccgtc tcccgggtaa tgttttttct ccatgccgaa
     3961 gttcgtgcat ctgtgctcaa cgaacatgtc catttcttcg aagctaccct cgtcaagcag
     4021 catagccaga cgctcgcgtg ctgtgtattt ccctttttcg tgttgcttcg caattgcttt
     4081 ttcaccgcct ccgatacgtg ctacggcacg gcgttcaata agctctttaa ttttttcaag
     4141 ttgattactc atgagttctt gttggtttta gagtttatga ttaatgttcg cagagttctg
     4201 ttaacacacc caaagttgat ttcgggtgaa ggaaagcgat attcaaacct tcagcacctt
     4261 tgcggggagc tttgtcgata aggcggattt ctttgccttc tgcctctgcc agcgcattgg
     4321 ctacgccatc ttctacagca aatgcgacgt ggtgaacgcc tgcacctttg ttttcaatga
     4381 atttggcaat agtactctcc gggcaagtag gctccaacag ttcaattttt gtttcgccca
     4441 cttttaaaaa agcagttctt actttctgat cttccactgt ttcaatgttg taacacttca
     4501 gacctaatac attttcgtag taaggaaggg cttcttcgat gctttttaca gcaatgccca
     4561 gatgttcaat gtgtgaaatc ttcataacta tacttttttt atttggtttt aaatctgtgc
     4621 ttataaggca taaaacagca caaagaaaga catttcttat ctaataaaga aatatttctg
     4681 catttaatta ttggattatt aaacagaaaa aatggtggga aaggagcata aaacattgtt
     4741 ttgtaatctt gagattacat ttagacataa aacttgacta agagtttatt cagccaactc
     4801 caattgacgc ggaaccaacg gcgggtactg ctttgttttc ctccgaagcg aagaacgaaa
     4861 tcacgataac cgtgtttacg gaacggaagt cctacatcca taaattccat gtggcggaat
     4921 ccccgttggt gtgcgtcttc caatgctttc caaacagcta gcacacccgg atattgaagt
     4981 gcgtatgtct ttctcattcc tcccgaaaac caaaggtatg cgtcgtctcc cgaatagata
     5041 cagacagaac cgccaatgat tttctctttg tatttcacaa cgaatatttt tgcctgttgt
     5101 cctttgatta acatatcgtt catgtggcgg aaaaagtcgt tggcagggaa atatctgcgt
     5161 atgcgggagg aataaacctt gtgcagcatc cgtgagaaat cgtgtatctc ttccacggta
     5221 tgtgcttcct ctactctggc tccattcttg agtccttttt ttatctgacg catacgcgac
     5281 ggactgaacc ggtcttccgt ctttttcata ctgtgcagcg aattgcgtac ccgcaaccaa
     5341 ttgacaggga aataatcatt ggcacggaaa acccgatagc cgaacatcga attgttcagg
     5401 ttccggaatt cgatcaggac acagctgcgc gatgcttctt gtgtgagatg ttcgagcata
     5461 tcgccgaaga cttcttctgc cttttctttg ttggtcgaaa gagactcgtc cagaaattcg
     5521 ccttcactat atactacaca atgtttcact aaagaagaag ggagccactt ctttgctttg
     5581 cggatggcag caagcaggcg tgccaccggt ctgccgtctt ctgttgccac tattaataaa
     5641 ggagtatacc caggagttgc ttcataaatc agaaataact ctttggaatg gaaggtattt
     5701 tttcccggca attcaggaat atccttccca tgataatatg ttgttagttt cagtggcatc
     5761 taggtacaaa tttacacttt ttattcttta ttcaacaaca aaataaagaa tttgttggag
     5821 ctgcttgaag taaagtataa tatatagttg cgtatttaat ggagaaaata tattttatag
     5881 gagaaatatg gtatgaaaag tgagtacgta ttaaaattag attcgtcttt aattaagatt
     5941 ataatcgaat agtttttgca aaacaacgag aattaatatt aactttaaat tagaacgaat
     6001 gagatgtaat gcatttgttg aagcatggaa gaatcatcat agacgcgctt ccatgatttt
     6061 agggctgtct ttattgtctg cccctctgtc atattctgtg tatgcagaag atggagtttc
     6121 taatactatg gtgcaagttg tcacacaaac gaaaactgtg aaaggaacta tcattgatga
     6181 aagcggggag ccgttgattg gggtttctat cgttgtgaaa ggaacaagta caggtacgat
     6241 taccgatttt aacggtaact tctctatcaa tcttccggcg ggaagaaaag aactggtcat
     6301 ttcttatatc ggttacaaag aacaaacggt gactgtgacg ggcaacggac cggtcaatgt
     6361 gaaaatggtt tcggacacac aggcattgga tgaagtggtt gttgtgggtt acggtacgat
     6421 gaaaaaacgc gatttgacag gagctatcac ttctgtaaaa agtgaagatg tagtgatgaa
     6481 tccaagttca aatccgatgc aggctttaca aggtaaggtg gcaggattgg atattacgcg
     6541 tgaatcggga caggccggtt cgggagtaaa gatgcagttg cgtggtaacc ggtcattcca
     6601 gaaggattcc ggaaatcctt tatttataat tgatggtatg ccgggggatt attctacatt
     6661 gaatccgaat gatattgaaa gcattgaagt tttaaaagat gcttcttcga cagctattta
     6721 tggttcaagt ggtgcgaacg gtgttatttt aattactact aaaggtggta aggaaggcaa
     6781 agcaattgtt aattttaatg catacgtagg tgtaaacggc tggtcaagga ctccggagat
     6841 gcgtagtgga gaaagttata tacaaacctt gagagatgca tctgttggtg ctggcgatgg
     6901 acgttggagc tcggttgctg atgataaaaa tctgtttact actgatgctg aatggaatgc
     6961 acatcaaaat ggccaatata tagattgggt ggatgctttg ttgaaaacca gtgtaacaca
     7021 gaattattct gtttctgtgg ctggtggaac ggaaaataca aaggcatatt tttctctgaa
     7081 cttctctaat gaggatgggc agtttgcaca agatagttat aaactttatt catctaaaat
     7141 ccgggtagat cataagatta aaaagtggat gaaggtgggc attgatgctc aactgtctta
     7201 tgtacatcaa aataaagctg attctgattt acagactttg atggcgtcaa atcctcttgg
     7261 atcgttgtat aatgaagatg gaagcatcaa tccgcaacct gttgccgatc cttcatctac
     7321 agtatataat tatcttttaa atgaggataa aagtttgtac cgcaatcagg ctcaaaacct
     7381 taaggtctat tataatcctt acttggaaat cactcctctt aaaggactga cttttattac
     7441 tcgtgctggt gctaatttgg gatattcacg tagtaacact ttcacaggag aggggtctgt
     7501 tcaatggtat aaggcaaatc aaacggcaga cggcattaag gcgcaagtta aggacaaccg
     7561 ttcgtataat tataagtggg aaaatatact tacttacaat ttccagatta agaaagtgca
     7621 tgatataact cttactgcag ttacatcgtg gaatcacaat cgtagcgatg tcactacttt
     7681 gtatcaaaaa ggtgtttctg ataataaatt cttatggcat aatattcttg atggtaattc
     7741 cgcaacttcg ggaagtactt cttatagtat gtctaagggg atgggatatg tcggccgttt
     7801 gaactattca tatatgggta ggtatttatt tgctgcatct gtccgccatg acggctcttc
     7861 cagactggca gaaggtaata aatgggatac tttcccggct ttttctttgg gatggagaat
     7921 ttctgatgaa aaatttatgg agagtacgac taactggttg agtaatctga aaatccgctt
     7981 cggatatggt gttacgggta gtacagcggg gattgatccg tattcgtctg ctgcatcatt
     8041 ggatgctact gctgtaaata tgatattagg aggtgttctg acaccgattt ataaattctc
     8101 acagaatatt ccgaactatt tgcttacatg ggaaaagtcg tataacacga atattggtat
     8161 tgacgctgca ttcttaaata atcgcattga tgtcagtatg gaatattata atacaaaaac
     8221 aaaagatgtt atatggaaca aggcacttcc tgttattaat ggagcattct ccccggatgg
     8281 cggacctaaa gcgaattata ctactaattt aaatatgtgt gagactagca ataaaggttt
     8341 tgagttggct cttaatacac gtaatattat aacaaagaac tttacctgga gttcaagtgt
     8401 aactttcaat cataataaag agaaaataac caaattgtcc ggtggagatt cagatgtgct
     8461 taataatggt gacaccggtt atgcattggc attgggagaa gctattaact cttattatca
     8521 ttataagttg gatggtgtat ggcaaaaagg tgaggaaact gatgcggcgg tatttggtgc
     8581 tgcacctggt gatttgaaaa tcaatatacc taatttagta aaagaatctg atggtagatt
     8641 ctataaaata gatgaagaaa cgggtagtgc tgctgtggat gaaaatggta atgttattta
     8701 ttacacttct gataataaat atactccaag tgatgcagat tatcaaattc tgggtcacaa
     8761 ctctccggat tggtctttag gattccagaa taattttacc tggaaggatt ttgatttaag
     8821 tgtgtttgtt tatgcacgtt acggacagat gtttgcttat gatatgttga cgtcttatga
     8881 cccgaagggt atacgtaact tcccgaccta tttcaattat tggactgaaa acaacccttc
     8941 aaatgatttt cctgccgcca atgctaataa aggtctcgaa caatatacgg gatattacgc
     9001 attacgctat gtagacggtt cgtttataaa gattaagaac attacattgg gatatagtct
     9061 gccgaaatct atcttaaaat cagccggtat agagaagtgt cgtttctatg ctaccattac
     9121 aaatccgttt gtatttgcga aaagccattt gctgaaagac tatgatccgg aaatgaatgg
     9181 ttctctgaag tacccattga ccaaacaatt tgtatttggt gtaaatgtta cattctagtt
     9241 tttcactaaa aaaagtattg aaatgaaaag tacaatctat aaaatagcag cgcttacatt
     9301 cgctgtggct tcaatgtctg cctgctcgct tgatgagtat aatccaagcc aaaaaacagg
     9361 agatgaaatt cttgcaacgt tcgatgggct taaaggatta cagtcttatt gttattcatc
     9421 actttacggg cagttattca gtgtctatga tttcttgtct gtggctgaag gtggtacgga
     9481 ctgctggata actcctgccg gtaatccgga ttatgccaag caggtgattt attatgatgg
     9541 tttagctacg aatacgaatg ctacaaataa attattcggt caggcttatt ctatgatcgg
     9601 taattgtaat gcagtagtaa acagggctga attactaacg gatggcaatg aaaaagatat
     9661 aacgacttta gtggctgaag cccgctgtct tcgtgcgttt tattattcca tattggtgaa
     9721 tacgtatgga aatgtaacgt taacattgga agaatcgtct caagatccta ttttgactcc
     9781 gcagcgtaac tctattgaag aactatatac gcagataatt gatgatttga aatttgcggc
     9841 caataatctt gaagatactc cttatgatag taatcgtgcg cgtgtgacta agaaaaccgc
     9901 gttaggactt ttggctcgcg tttatgctca aggtggtggc gaatatgggc tgacagaaga
     9961 tggagtatct tattggcaac gtgctaaaga agtggcagag gacatgattt tagcgtatgg
    10021 tgactgtttg tatgatgatg tggaagatgt ttgggctccg gcaaataatc gaaataataa
    10081 agaagcttta tttattgctg ccggtccgga tgctacgaat ttggagaatt ggaatgctgg
    10141 aacacaatgt aataataact ttacttatat gtatccaaag ccaaatactc tcactattta
    10201 tcctactccg gataatcaga attattggta tggacgtacc aataataata cgttggcacc
    10261 ttccaaatat ttgctggatt gttttgatgc tgattatgat aagcggtggg aagtaacctt
    10321 tactacggct tttgtacagt tttctgccgt acagtcagga ggtagttatt tatttactaa
    10381 taagaagcag acattggatg atggtacaaa accaaaaatt ggaacaaaac atggcgtaaa
    10441 tgataatatt agttcattta caattcttac tcaaaatata atcgatactt atggattgga
    10501 tgcaaaattc cataatgagt atatttatcc ttatggtgat ttgaattata catattatga
    10561 tggaacttgg gcgcccaaaa tgatagccaa ggtttggccg aaaggtgaaa atagcggtga
    10621 tccttccaaa ttgcaggaag tgaagaaccc ctatgtgata ccttaccctg tagctgaaga
    10681 tgatgataga atctgtttct acttatcaaa ggaaagactt tcggatgcgg agaaagcgaa
    10741 acgtagatat tatgtaatca atattgatga tttgtttgat aacggacaat atcgtaaaac
    10801 agatataaaa gtcactaatg acaaaaatat gtaccctggt ttcaacaaat acaattggtt
    10861 gtcggaagat tcatatagta gcaatttgca acgtaagaca ggtgatgtgt tcattatgcg
    10921 tatggctgaa gtatatctga ttgcagctga agctaaccaa caattaggaa atggcggaaa
    10981 agctgctgaa tatttaaatg tactgaaaaa gcgtgccgct cgcaatgatg catcttacaa
    11041 tgctatgaaa ttgagtaatg ctacacagaa tgatgttatg gacgaatatg ctcgtgaatt
    11101 atgtggagaa tatcaacgtt gggtattgat gaagcgtcac aaagattctt tcaaacaacg
    11161 tcttgctgtt ggtaatcctc gtgcagctga aaattttgat gaaaacaagc attatttgcg
    11221 tccgatttct tttaacttct tgagtcagat tgataatgca gaagaatatg gaaacaatgg
    11281 gtattagtac tcttacagat taaatttaga ttaaagaggg gatatgtcgt gatgatatgt
    11341 cccttttttc tatatctttg tgtaatcgaa cagaactttt aaaaagcgga actatgttag
    11401 aagaaatttt agcttacaac aagcaatttg ttgagaacaa gggatacgaa tcgtatatta
    11461 ccaataaata tcccgataag aaaatagcta ttctttcctg tatggatacc cgactgactg
    11521 ctttgctgcc agcagcatta ggaattaaga atggcgatgt gaaaatgata aaaaatgcag
    11581 gtggcgttat ttcccatcct ttcggtagcg tgatacgtag tttacttgta gctatttttg
    11641 agttgggggt agaggaaata atggtgattg ctcattctga ctgtggagct tgccacatgc
    11701 acagtgaagt aatgctcgaa aaaatgaaag cacgcggaat caatccggat tatattgata
    11761 tgatgcgttt ctgcggagtt gactttcatt cgtggctgga tggtttcgaa gatacagaaa
    11821 agtcggtgag aggaacggta gattttattg tgcgtcatcc tttgatccct tcagatgtga
    11881 cagtctacgg gtttattatt gattctacga ccggagaatt aactcggatt gtatagatta
    11941 ttagatagat aggtaaatag ataaacttct tttttaatcc cctaaatata gtgacgctat
    12001 cctatcatga tagtgacgcc atttctattg tatagtgtcg ctatgtctgg aggatagtga
    12061 cgctattttg aagacaaaaa aataaggcag ctttttatcg gctgccttta tctttctgcg
    12121 gttatatact ttctttgact ggtgcactcg tttgtgacaa atagggtgcc cgtacatctc
    12181 aatttctgcc tcacggctag ctttacgatt cgctttaacg taatcgtcct gtgtaattcg
    12241 ctttttcata atgaaattat ttctctgtgc aaagatacaa tatattcttc atttagtata
    12301 aacttttatt tcctattacg ctcggtttgc attatctttg catacattaa tcaaatgaaa
    12361 ccggaaataa tatggaaaat ttcagtgaat taataaagaa ccgtcgtagt atgcggaagt
    12421 tcaccgatga agaattgaca caagatcagg tagttgcgtt gatgaaagca gctttgatgt
    12481 ccccttcttc caaacgtagt aatagttggc agtttgtagt ggttgatgat aaagaggtat
    12541 tgaaagaatt gtctcattgc aaagaacagg cttcttcgtt cattgccgat gcagctttgg
    12601 cgattgttgt aatggccgat ccgttggcca gcgatgtttg gattgaagac gcttccattg
    12661 cttccatcat gatacagttg caggctgaag atcttggctt gggaagttgt tgggtgcagg
    12721 ttcgcgaacg tttcactgcc accggaatgc cttccgatga atttgtccat ggaattttgg
    12781 atattccctt gcaacttcag attctttctg tcattgctat cggacataaa gggatggaac
    12841 gtaaaccttt caatgaagaa catcttcaat gggagaaaat tcatattaac aagttcggag
    12901 gaaaataagt atgggagctg ctaaagcgaa taatagtaaa gatacctatc tggctactgc
    12961 tgttaccttt atcgttatcg gagcacttta tctgattgat aaactgattc atttctcttc
    13021 cattggactg ccttgggtga tgaataagga caatatgcta ttgtacgcct cgatctgttt
    13081 ccttattttc aaacgcgata aatcaattgg ttttgtgttg cttgggcttt ggctagtgat
    13141 gaatatcggt ttggtcatgt ccttattggg ttcgttatcc ggatatctgt tgccattgac
    13201 actgctcatc atcggaatcg ttttattctg gtttgcaaaa cgataagaga ataatgaaaa
    13261 gaagtataga agatacaccg atcgtgttta tcggtgcagg taacttggct actaatctgg
    13321 cgaaagctct ttatcgtaaa ggtttccgca ttgtacaggt atatagccgg actatggaat
    13381 ctgcccgtac cttagccgag aaagtagaag ctgaatatac aacagattta caggcagtct
    13441 ccaaagatgc aaaattgtat atcgtatcgt tgaaagatga tgctttagta gatttgttac
    13501 cgcagataac agaaggaaag caagcgtctt tgttggtgca tacggcagga agcattccga
    13561 tgagcgtttg ggaagggcat gcagaacgtt acggagtatt ttatccgatg cagacattca
    13621 gcaaacaacg tgaagttaaa tttcaggaag tgcctttctt tgttgaagcg aaaaggccgg
    13681 aagacgtgga attgttgaag gctgttgccg ccacactttc ggaaaaggtc tacgaggctt
    13741 cttccgagca acgtaagagc cttcatttgg ctgctgtttt tatctgtaac ttcaccaatc
    13801 acatgtatgc attagcagct gatttgcttg aaaaatacaa cttgcctttc gatgtcatgc
    13861 ttccgctgat agatgaaaca gcacgtaaag tccacgaatt ggcgccacgt gatgcacaga
    13921 ccggacccgc tgttcgttac gatgagaatg tgatgagtaa tcatcttgcc atgttggtag
    13981 attctccggc attgcaggaa atatataaac taatgagcaa aagtatccat gagcaccatc
    14041 aattatgatt tatcccgtat caaagcttta gcttttgatg tggacggagt attgagttcg
    14101 acaaccgtac ctttgcatcc ttccggagaa ccgatgcgca cggtgaatat caaagatggg
    14161 tacgccatcc agttggctgt gaaaaaagga cttcacatag ctatcatcac cggtggccgg
    14221 acagaagcgg tacgtatccg ttttgaggga ctgggagtga aggatttata catgggttct
    14281 gctgtgaaga tacatgatta tcgtgctttt cgtgataagt acggattgac cgatgatgaa
    14341 attctatata tgggtgatga cgtgccggat attgaagtga tgtgtgagtg cggactgcca
    14401 tgctgcccga aagatgccgt gccggaagtg aaatccgttg caaagtatat ttcttatgca
    14461 gacggtggtc gtggatgcgg acgtgatgta gtggagcagg tgctgaaagc tcacggtcta
    14521 tggatggtgg aagacgcctt cggttggtaa cttaatcata aataatcgtt gtttaataac
    14581 gaata
//
