LOCUS       c00032_gnlPro..        16247 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HOKEMPBB_32.
ACCESSION   c00032_gnlPro..
VERSION     c00032_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 07:05:47
            Original ID  :: gnl|Prokka|HOKEMPBB_32
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16247
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16247
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2695:6247](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2696..6247
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16247
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16247
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(123..1352)
                     /locus_tag="ctg32_1"
                     /transl_table=11
                     /translation="LQNKVLNSFKMTKKALYIFNPEHDLALASGETNYMAPASARQMAS
                     ELALLPMWYAEEGSVVLAPSAYNLDYVKKIQELLGLSVDLMTEPELASERNLDIRPWGW
                     DIAIRKRLLDLGVEESELPSIEQLDKLRFCSHRSCAVGLLPQLQLGACFCGESFYLTFP
                     EEWKSFVESHDTCLLKAPLSGSGKGLNWCKGVYTPSISGWCSRIGNQQGGVIGEPLYNK
                     VEDFAMEFRSSGNGRFGFAGYSQFRTGGSGAYEGNLLISDAAIERNLLEYIPVEEIYKL
                     RDRLEQELSLRFGTIYNGYLGVDMMICRFPESPVYRIHPCVEINLRMNMGVVARHIYDH
                     YIYPTSTGAFQISYYPTEGTAWRAHKEMEEAYPLEIEQGRIKSGYLSLVPAHKKSSYRA
                     WVFISKSVFL"
     CDS             complement(1491..1772)
                     /locus_tag="ctg32_2"
                     /transl_table=11
                     /translation="LVDQQYFSTTFLEFVSKVYNAVAREVEVVHVDEQAGAVVPKFFFG
                     VLEKESGFSYATCPFDTNQAVAPVDLVHKIAANGGIGVLNEVGVCAIE"
     CDS             1803..2663
                     /locus_tag="ctg32_3"
                     /transl_table=11
                     /translation="LRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFR
                     EYLNLQTGMKFRAYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFS
                     ENLLKTMNMMVEVDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRAT
                     VMNYIKYLADARLINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFAN
                     SLWKDHKVHKGDKNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWM
                     FGFLY"
     CDS             2696..6247
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_4"
                     /sec_met_domain="PFOR_II (E-value: 1.7e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 2e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 2e-31, bitscore: 100.4,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.1e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 6.9e-12, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 1.1e-08, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 5.5e-05, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 3.4e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMNPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKTKQHLVDIKSNVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARIVKLFNEILAADNASPEAKEVLKAWIENMYDADKTKE
                     LAPQVKAVIEEGLSHGCPICKELKGLTQYLVKRSQWIIGGDGASYDIGYGGLDHVIASG
                     KDVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQI
                     AMGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLW
                     RYNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAK
                     WRYNSYKRLARENWGAE"
     CDS             complement(6208..6357)
                     /locus_tag="ctg32_5"
                     /transl_table=11
                     /translation="MNSSGKKVVLFMLDRVHTIKNGNLLQDYRFLFIGYYYYSAPQFSL
                     AKRL"
     CDS             complement(6399..7271)
                     /locus_tag="ctg32_6"
                     /transl_table=11
                     /translation="MHVRIYKIVGIVLSAMLLLASCTNSDLEKKKVKIAYANWLEGIAM
                     SHLAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEF
                     LGEVYGEARVGLVVPQYVTIQSINELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGL
                     DGYTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEI
                     HAIAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRLLVD
                     SWIPKSENK"
     CDS             complement(7289..8113)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.5; E-value: 8.7e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg32_7"
                     /sec_met_domain="BPD_transp_1 (E-value: 4.4e-29, bitscore:
                     92.5, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMVHFSTFFDAVNAGIGSFIIGFQHILFGIP
                     FYITILVLATLAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSPRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(8110..9312)
                     /locus_tag="ctg32_8"
                     /transl_table=11
                     /translation="LYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKDANLSINEG
                     EFFVIMGLSGSGKSTLLRCINRLIRPTAGQVLVNGVDISKISEKELLQVRRKELAMVFQ
                     NFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGDLSGGMQQR
                     VGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITHDLSEAIKL
                     GDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMIDKPLVARLK
                     KEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSKQEKSIETIVRTEVHSV
                     LEDTVLEDILPLMTKSNSPVWVIDETREFLGTIPLSSLIIEVTGKDKEEINEIIQNAID
                     L"
     CDS             9369..9482
                     /locus_tag="ctg32_9"
                     /transl_table=11
                     /translation="LFSTAAFLILTYDKQVECSHGSVMPHDNMTVRRFLNG"
     CDS             complement(9635..9973)
                     /locus_tag="ctg32_10"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMSQ
                     CSRMVGRALKQIPDDLSAPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             10069..11352
                     /locus_tag="ctg32_11"
                     /transl_table=11
                     /translation="LLYLQIIPTFVPNKSNPIINKTSTAVMKKKTILFASCLLGALAFS
                     SCEKNLYDESKQPEKEKRITDLNIPADFDWKGSQNAKVKIASQSTATISVFLEENCNEE
                     ALMLRMDVDANISKLELPIEIPAYIKNVYVKYGNGSEIQTVPVESNGTISIVVPANATA
                     LSRVTTRANKEVETNNIFNYPGYGNGTIMFEDMYPALGDYDFNDFVAWYNFQIDGFYWS
                     HNQCYAEYLMIGFQIRAIGGIYDYNPYIRLAEVQYNELDLEETQMYLERNNPEEAENIK
                     ILKGPKGELIISLKKPAIPNGYKYYNTEVNEKTKPKKMMAIYLVFNSPVNVKSLQDSKM
                     DFYIAKTNKGQEIHLKGYSPVYYNSNESYVNEDNFIWGLKVPASLHHAREEVNFLEAYP
                     DFEQWVTSGGQKNQRWWNKPKTNKLIMN"
     CDS             complement(11494..14376)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 62; E-value: 2.1e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_12"
                     /sec_met_domain="Peripla_BP_1 (E-value: 1e-19, bitscore:
                     62.0, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEAMKYTKWITVLLCLLGLAACRQDAPRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDKGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNYPDIKLIDKADAAWEREPAEVEMDSMLHRHPKIDAVYAHNDRI
                     APGAYQAAKKAGREKEMIFVGIDALPGKGNGLELVLDNVLDATFIYPTNGDKVMQLAMN
                     ILEKKSYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRSKNRLNKELSEQKKQVEQQRDKLEEQRDILEEQRD
                     KLEEQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADSSLSEDQR
                     RMLLLVQRNVNILLRLVNQILDFRKYENGKMEYTPISLDILSSFEGWNESFMAAARKKH
                     IHFSFDYMPDTDYRTLADVEKLERIYFNLLSNAFKFTPENGKVTVRLSSLTKDDHCWIR
                     FTVANTGSMISAEHIRNIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTITVESDEKQG
                     TIFTVDLPVQTCETVVSENSPAFSVPATSVTSTDAATSAVAGAPVTPATSGYSGSSSLN
                     DALTYEEEELEKSYDSSKPCVLIIDDNADIRLYVHGLLHTDYTVIEAADGSEGIRKAMK
                     YVPDLIISDVMMPGMDGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYI
                     SKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGD
                     SNLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGY
                     EVGFSSPSYFTKCYREQFGESPTDLLKRKG"
ORIGIN
        1 tcacatggca tgtgattact tgtttcatgc aatgaaactt tttgtttctc ggtgtggaac
       61 caatggtttc actgcatgaa actatcagtt tcacaccgag aaaccataac ttcgatataa
      121 tatcacaaaa acacgctttt tgagataaac acccacgccc gataactact ctttttatga
      181 gccggcacca atgacaaata gcctgatttt attcttcctt gttctatttc caaaggataa
      241 gcctcctcca tttctttgtg tgctctccag gctgttcctt ccgtagggta atagcttatt
      301 tgaaaagctc ctgttgaagt aggatagata taatggtcat aaatatgacg cgctactact
      361 cccatattca tcctcaagtt gatttccacg caaggatgaa tccgataaac aggagattct
      421 ggaaagcgac agatcatcat atccactccc aaataaccat tataaatggt tccgaaacgg
      481 agggataatt cttgttcaag gcggtcgcgc aatttataaa tttcttcgac agggatatat
      541 tccaaaagat tccgttcgat ggctgcatct gaaatcagca gattaccttc gtacgcccca
      601 cttccacccg tacggaattg agagtatccg gcaaagccaa atcgaccatt acccgaagaa
      661 cgaaattcca tagcaaaatc ttccacctta ttatatagag gttcgccaat aacacctcct
      721 tgctggttgc caatgcgtga gcaccaaccg gaaatggaag gagtatatac acctttgcac
      781 caattcaacc cttttccgct accggataaa ggagctttca gtaaacaagt atcatgtgat
      841 tctacaaatg acttccattc ttcgggaaac gtcaggtaaa aagactctcc acaaaaacag
      901 gctcccagtt gtagctgtgg taataatccc acagcgcagg aacgatggga acagaaacgc
      961 agtttatcca attgctcaat agaaggaagc tcgctttctt ccactcccaa atccaacagt
     1021 cgttttctta ttgctatatc ccagccccaa ggacgaatat ccaaattccg ctccgaagca
     1081 agttcaggtt ctgtcatcaa atcaaccgaa agtcctaata attcctgtat cttcttcaca
     1141 tagtcgagat tataagcgga aggagccaat acaacacttc cctcttctgc ataccacatc
     1201 ggcaacaaag ccaattcgga tgccatctgc cgggcggaag ccggtgccat atagtttgtt
     1261 tcaccgctgg ctaacgccaa atcatgttcc ggattgaata tataaagagc cttttttgtc
     1321 attttaaacg aattcaaaac tttattctgc aaatatatac aggaaatagt caggaatggc
     1381 tacaataaac agaaagttct aattaaactc acaattttgc catctctact ttgcaaatcc
     1441 taaaaaaagc agtatatttg ccacccgaaa aacaaagaac tgaaatggaa tcattctatc
     1501 gcacacacgc ctacctcgtt gagcacacca atgcccccgt tcgccgcgat cttatggacg
     1561 agatcgactg gagcgaccgc ctgattggta tcaaagggac acgtggcgta ggaaaaacca
     1621 ctttccttct ccaatacgcc aaagaaaaat ttgggaacga ccgctcctgc ctgttcatca
     1681 acatgaacaa cttctacttc tctggccaca gcattgtaga ctttgctaac gaattccaga
     1741 aacgtggtgg aaaagtattg ttgatcgacc aagtgttcaa acacccggaa tggagcagag
     1801 agttgcgcat gtgttacgac cgttttccta atttgaaaat tgtctttacc ggctcatctg
     1861 taatgcgact gaaagaggaa aatcttgaat tgcgtgatat tgcaaaaagc tataacctgc
     1921 gcggattttc tttccgcgaa tacctgaact tacaaacagg catgaaattc agggcctaca
     1981 gtctcgaaga aattcttagc actcacgaac agattgccaa aggagtactc tctaaagttc
     2041 gtccgctgga ttacttccag gattacctgc atcatgggtt ctatccattc ttcctcgaga
     2101 agcgtaactt ttcggagaat ttgctgaaaa cgatgaacat gatggtggaa gtagatatcc
     2161 tgctcatcaa acaaattgaa ctgaaatatc tttcaaagat aaaaaaatta ctatatttgc
     2221 tcgctgtcga cggaccgaag gctcccaatg tgagtcaact ggcaagcgac atacagacat
     2281 ctcgcgccac ggtgatgaac tatatcaagt atctggcaga tgcgcgactc attaatctgg
     2341 tttatccgaa aggagaagaa tttcctaaaa aaccttccaa gataatgatg cacaactcca
     2401 acctgatgta ttccatctat cccgtgaaag tggaggagca ggatgtactc gacacattct
     2461 ttgcaaattc tttatggaaa gaccataagg tacataaagg agataaaaac gtctctttta
     2521 tggtggacga agtaatgccg ttcaaaattt gccaggaagg agcaaagatc aagaacaatc
     2581 cgaatgtgac gtacgcgttg cataaggctg aaataggtcg gggcaaccag atacctctct
     2641 ggatgttcgg ctttttatat taaaagattt atttacttaa atatttaatt tagttatgac
     2701 taaacagaag aaattcatca cttgtgatgg taaccaggct gcagcgcata tctcgtatat
     2761 gttctctgaa gtagctgcta tctaccccat cactccttct tcgactatgg ctgagtacgt
     2821 agacgaatgg gctgccgcag gacgtaagaa catcttcggc gaaacagtat tggtacagga
     2881 aatgcaatct gaaggtggtg ctgccggtgc agttcacggt tctcttcagg ctggtgcgtt
     2941 gactactact tacactgctt ctcaggggct tctcctgatg atccctaata tgtacaaaat
     3001 tgccggtgag ttcttgcctt gcgtattcca tgtatctgct cgtacattgg cttctcacgc
     3061 attgtgtatc ttcggtgacc accaagacgt aatgtcagct cgtcagactg gctttgcgat
     3121 gttggctgaa ggctctgtac aggaagttat ggatttggct ggtgttgctc acttggctac
     3181 catcaaatct cgcgttccgt tcatgaactt cttcgatggt ttccgtacat ctcacgaaat
     3241 ccagaagatt gaaatgttgg aaaatgatga tcttgctccg ctgatcgatc aggaagcttt
     3301 ggctgaattc cgtgcccgcg cactgaatcc gatgaatccg gttgctcgtg gtatggctga
     3361 aaaccccgac cacttcttcc aacatcgtga atcatgtaac aactactatg aagcagttcc
     3421 tgctatcgta gaagaataca tgaatgaaat ttctaagatt acaggtcgta aatacggttt
     3481 gttcgattac tatggtgcag aagatgcaga acgcgtaatt atcgctatgg gttctgtaac
     3541 agaagctgcc cgcgaagcta tcgaccactt ggtagcaaat ggcgaaaaag tgggtatggt
     3601 tgccgtacac ctgtatcgtc cgttctctgc taaacacttc ctggctgctg tacctaagac
     3661 tgccaagact atcgcagttc ttgaccgtac taaagaaccg ggcgctaacg gcgaacctct
     3721 ttaccttgac gttaaagact gcttctacgg cgcagaaaat gctccggtta tcgttggcgg
     3781 tcgctacggt ttgggttcaa aagatactac tcctgctcaa attctttcag tattcgaaaa
     3841 cttggccatg ccaatgccga agaatcactt cactatcggt atcgtagacg acgttacttt
     3901 cacttctctt cctcaaaaag aagaaatcgc tttaggcggt gaaggaatgt tcgaagctaa
     3961 attctacggt ttgggtgctg acggtacagt aggtgctaac aagaactctg taaagattat
     4021 cggtgacaac actgacaaac actgccaggc ttacttctct tatgactcta agaagtcagg
     4081 tggtttcact tgttctcact tgcgtttcgg tgatactccg atccgttcca cttatttggt
     4141 aaatactccg aacttcgttg cttgtcacgt tcaggcttac ctgcacatgt acgatgtaac
     4201 tcgtggtttg cgtaagaacg gttctttctt gctgaacact atctgggaag gtgaagaact
     4261 ggctaagaac ctgcctaaca aggttaagaa atattttgca cagaacaaca tttccgtata
     4321 ctatatcaac gcaacacaga ttgcattgga aattggtttg ggtaatcgta ccaacactat
     4381 ccttcaatct gcattcttcc gtatcacagg tgttattcct gtagaccagg ctgttgaaca
     4441 gatgaagaaa ttcatcgtta agtcttacgg taagaagggt gaagacgttg ttaacaagaa
     4501 ctatgctgcc gttgaccgtg gtggtgaata caagacttta gctgttgatc ctgcttgggc
     4561 taacctgccg gatgatgcaa aagctgaaaa caacgatcct gcattcatca acgaagtagt
     4621 tcgtccgatc aatgcacaag atggtgactt gctgcctgta tctgcattca agggtatcga
     4681 agacggtact tggtatcaag gtacttctaa atacgaaaaa cgtggtgtag ccgcattcgt
     4741 tcctgaatgg aatccagaaa actgtatcca gtgtaacaag tgtgcatacg tttgtcctca
     4801 cgcttctatc cgtccgttcg tactcgatgc tgaagagcag aagggtgcta agttcgaaca
     4861 attgaaagca gtaggtaaag tattcgacgg tatgacattc cgtatccagg ttgacgttct
     4921 cgactgtctg ggttgcggta actgtgctga catctgtccg ggtaatccga agaagggtgg
     4981 caaagcattg acaatgaaac acctcgaaag ccaattggct gaagctgaca actggactta
     5041 ctgtgctgaa aacgtgaaga ctaaacaaca tcttgttgat atcaagtcta acgtgaagaa
     5101 ctcacagttc gctactccgt tgtttgagtt ctctggtgct tgctctggtt gtggtgaaac
     5161 tccgtatgtg aaattgattt ctcaattgtt cggtgaccgt gaaatggttg ctaacgctac
     5221 cggatgttct tctatctact ctggttcagt tccttctact ccgtatacta cgaacgaaaa
     5281 cggtcacggt cctgcttggg ctaactcact gttcgaagac ttctgtgaat tcggtttggg
     5341 tatggaattg gctaatgaaa agatgcgtgc tcgtatcgtg aagttattca acgaaatcct
     5401 tgctgccgac aacgcttcac ctgaagcaaa agaagtgctg aaagcatgga ttgaaaacat
     5461 gtacgatgct gacaagacta aagaattggc tcctcaagtg aaagcagtga ttgaagaagg
     5521 tctttctcac ggatgtccta tttgcaaaga actgaaagga ctgactcaat atcttgtaaa
     5581 acgcagccaa tggatcattg gtggtgacgg tgcttcttac gatatcggtt atggtggtct
     5641 tgaccatgta atcgcttccg gtaaggacgt taacatcctc gttctggata ctgaagttta
     5701 ctctaacaca ggtggtcagt cttctaaggc tactccggta ggtgctatcg ctaagttcgc
     5761 tgctgctggt aagcgcgtac gtaagaaaga cctcggtctg atggctacta cttacggtta
     5821 tgtatatgtt gcacagatcg ctatgggtgc tgaccaagct caaactctga aagctatccg
     5881 tgaagctgaa gcatatccgg gaccatcttt gattatcgct tacgctccat gtatcaacca
     5941 cggtctgaaa gcaggtatgg gtaagagcca ggaagaagaa gaaaaggctg ttaagtgcgg
     6001 ttactggcac ttgtggcgtt acaacccggc tctggaagaa gaaggcaaga atccattcca
     6061 attggatagc aaagaaccga actgggaaga tttccaaggt ttcttgaaag gtgaagttcg
     6121 ttacgcttct gtaatgaaac aatatcctgc tgaagctgaa gaactattca aagctgccga
     6181 agaaaacgct aaatggcgtt acaacagcta caaacgtttg gctagagaaa actggggtgc
     6241 tgaataatag taatacccta taaataaaaa acggtaatct tgtagaagat taccgttttt
     6301 tattgtatga actctgtcca acataaacag tactaccttt ttcccactag agttcatgtc
     6361 tattttatat ttaaaattaa gaataacaat gctccaatct atttattctc tgacttcgga
     6421 atccaactat ccaccaacag ccgatgctca tccctccatt tacgggctat ttcttcttca
     6481 tccatcctgg catccttcat agctgtcata aaagagctaa gttcttctgt cgttagtttg
     6541 atgttgccaa agaactcggc agcaaacgga tctttctcac tgaatccttt ccatgcaata
     6601 gcatgtattt cttccaagtc tccatatact ttcttcggat catccaagaa tttcaagtca
     6661 aactggtcga acatccaatg cggtgtccac cccgtaatga caatccattc tcctttgtcc
     6721 atcgcttttt tcaaagaagc cagcatggtg gaactacttg aagtcatgag ggtataccca
     6781 tcaagtccgt aagcagcaat ggccttatcg gtcgtcttca ttatccctgc tcccgcatca
     6841 attcctacta tttcagaaga aaaacggtct ttattagctt ccagctcatt aatagactgg
     6901 atcgtaacat attgaggaac aaccagtccg acgcgagctt ctccgtatac ctcccccaaa
     6961 aattcgatgc tgtctccata ctgatccata taatctttca tcgttattgg taaccaggca
     7021 tccagaaaca catctgattt ctttcctgac atagatacaa aaataggggc aagatcagca
     7081 ttttgcaatt caacctcata tccatgctct tccaatacca ccttagccaa atgactcatg
     7141 gcaatacctt ccagccaatt ggcataggct atttttactt tctttttctc taagtctgaa
     7201 ttagtacagg aagctagcaa aagcatagcc gaaagcacta ttcctactat tttatatatt
     7261 ctcacatgca tttttattcc tttccgtttt agttcttatt ttttcgtcct gccattcctt
     7321 gtgtgatacg gtctaagatg atagctaaaa taacaacagc tataccacct tcaaacccaa
     7381 gtccgatttt catttgggta atacctttca atacaatttc tcccagacca ccggcagcaa
     7441 tcatggcagc aatgacaacc atagaaagcg acatcataat tgtctggttg acacctgtca
     7501 gaatggtggg caacgccaaa ggaagctgca ctttatacaa taactgccaa cgggtagccc
     7561 cgaacgaacg ggaagcttcc actacatttt taggaacttg ccgaattccc aatccggtaa
     7621 ggcggactac aggaggcata gcaaagataa tggtagcaaa cactcccggc actgctccca
     7681 atccgaaaaa caaaacagca ggaatcagat aaacaaaagc aggcatcgtc tgcatcaagt
     7741 cgagaacagg acgaagtatt ttctctgcac gcggactgtt tgccgtccac actcctaaag
     7801 gtacaccaac aatcagagcc agacaggtag atgaaaaaac gagagccagg gtttgcatag
     7861 tagcctccca gaatcccatt ccatagatca gtaataatcc caatgcggtg aaaattgccg
     7921 taccgcgtcc tgctttcatc catgcgagtg tagcaagtac caaaatggtt atataaaaag
     7981 gtattccgaa aagtatgtgt tggaatccta taataaaact accgatgccc gcattcacgg
     8041 catcaaagaa agtggaaaaa tgtaccatca tccaattgat ggccatctct atatattgtc
     8101 ctatatttat cataaatcta ttgcgttttg aattatttcg tttatttctt ctttgtcttt
     8161 cccggtcact tcgatgatta aggatgaaag cgggattgtt cctaaaaact cgcgcgtctc
     8221 atcaatcacc cataccggcg aattgctctt tgtcattaga ggaagtatat cctccaacac
     8281 cgtatcctcc aacacagaat gtacttctgt acgcacaatc gtttcaatgg atttttcctg
     8341 tttgctacgt aacttaagca agtcgttcag acgtacttct ccgaccagtt tatcatcggc
     8401 gtctatgaca ggtaatacgg tgatattctt cgcacgcatc ttacgaatca atacttcggg
     8461 accttctttc ttcagacggg ccaccaacgg tttgtcaatc attaaagaag aggcggtaat
     8521 aattttgctc ctatccacgt tttcaacaaa acgggctaca taatcgttag ccggttcagt
     8581 caggatttcc tccgaagtac ctacctgcac cacttctccg tctttcatga tggcaatacg
     8641 gtcacctagc ttaattgctt cactcaagtc gtgggtaata aaaacaatcg tctttttcat
     8701 ctttgattgc aaggccagta gttcatcctg catctgtacg cgaatcagag gatcgagagc
     8761 agagaaagcc tcatccatta aaagcacttc aggattatta gccagagcac gagccagtcc
     8821 gacacgctgt tgcattccac cggaaagatc gcctaccatc tgattttcat atcctttcaa
     8881 tccgacaagc ttcatgcttt ccatcgcttt cttctcacgt tcctctttct tcactccctg
     8941 aagttcgagg ccgaacgcga tattgctcaa tacggaacgg tgaggtaaca gaccgaaatt
     9001 ctggaaaacc atcgccagct ctttccggcg aacctgcaat aattcttttt cggaaatttt
     9061 agatatatct actccgttta caagcacttg tccggcagta ggacgtatca gacgattgat
     9121 acaacgcagt aatgtcgatt ttccacttcc cgagagtccc attatcacga aaaactctcc
     9181 ttcattaatt gaaagattgg catctttcac tcctaccgta caaccggtat ctttcagaat
     9241 ttcctcttta ctcttatctt ttttcaacat cttgagggct ttctgcttct cgttaccaaa
     9301 gataaggtac aaatccttta tttctatttt actcatataa tatattggtt tagattataa
     9361 tatttgtttt gttttcaact gccgcattcc ttattctcac ttacgataaa caagttgaat
     9421 gttcgcatgg ttcagtcatg ccacatgata acatgacggt ccgacgtttt ttaaatggtt
     9481 aaaaaaaaca gacagagtag tttaaaagga atagaatttg ataagattat cctcttaatg
     9541 aacagtagaa aatagtattt tcataaataa ataacagtct gttcttgcat attgttggca
     9601 caaaggtaag gaaaatagat taaatatgca aatttcattc aggtacggag taattccaaa
     9661 gatgcttttt caagtctacg catccatttt gtttgaaaga gatcccttct tccaacaaga
     9721 gttgtttctg ctctgtccaa cccggaacaa gccgtcccga cgcattgaca acccgatgac
     9781 aaggcgcaga taaatcatcc ggaatctgtt tcaaagcacg ccccaccata cgggaacatt
     9841 gagacattcc caataatgcg gcaattcccc cataggtaga aactttacct accggaattt
     9901 ctcggacaac ctgatacacc tcttgacaaa aggatgcgga aaggctcgcc ttatctactt
     9961 tataatcttt catcactcaa acattacttt atttcagttc caaaactaga taaaaagaaa
    10021 agaatttgca aataataaaa gcatttcaaa taaaatatgc aactttattt gctttattta
    10081 caaataatcc cgacctttgt ccccaataaa agcaacccta ttattaacaa aacaagcact
    10141 gctgttatga aaaagaaaac tatcctgttc gcttcttgtt tattgggagc actggctttc
    10201 agctcctgtg agaagaacct ttatgatgaa agtaaacaac ccgagaaaga aaagagaata
    10261 acagacttga atattcctgc tgactttgat tggaaaggtt ctcaaaatgc caaagtgaaa
    10321 attgccagtc aatcaactgc tactatttct gtatttctag aagaaaattg caatgaagag
    10381 gctttgatgc ttcgaatgga tgtcgatgcc aacatatcaa aattggaact cccaattgaa
    10441 attcctgcat atataaaaaa tgtgtatgta aaatatggta atggctctga aatacaaact
    10501 gttcctgttg aaagtaatgg tactatttct atagtagtac ctgctaacgc tacggcatta
    10561 tccagagtta ccacaagagc taataaagaa gttgaaacga acaacatctt caattatccg
    10621 ggatatggca acggaactat tatgttcgaa gatatgtatc cagctttagg cgattatgat
    10681 tttaatgatt ttgttgcatg gtataatttc caaattgacg gtttttattg gagtcacaat
    10741 caatgttatg cagaatactt aatgatagga ttccaaatca gagctatagg aggtatatat
    10801 gactacaatc cttatatccg cttggcagaa gtacaatata atgaacttga tttagaagaa
    10861 actcaaatgt atcttgagcg taacaatcct gaagaggctg aaaatatcaa aatcctaaaa
    10921 ggcccaaaag gggaattgat tatttcacta aagaaaccgg ccattcctaa cggatacaag
    10981 tattataata cggaggtaaa tgaaaaaaca aagcctaaaa aaatgatggc catttacttg
    11041 gtgttcaact cacctgttaa cgttaaaagc ctacaagaca gtaaaatgga cttttatatt
    11101 gcaaaaacta ataaaggaca agaaatccac ttaaaaggtt atagcccggt ttattataac
    11161 agcaacgaaa gttatgtaaa tgaagacaac tttatatggg gattaaaagt acctgcatct
    11221 ttacatcatg ccagagaaga agtaaacttc ttggaagcat atccagactt tgaacaatgg
    11281 gtaacatcgg gaggtcaaaa gaaccaaaga tggtggaata agccaaaaac gaataagttg
    11341 attatgaatt aataaatata cagtaaatca tatactgaat taaataagag gtaaggtatg
    11401 tcaatagatt tccttacctc ttatttttat catatgaatt ccatagaagt ataaacagat
    11461 aaatgctcac catcaaattt tgcagattct atcctatcct ttcctcttca acaaatctgt
    11521 cggactctct ccaaactgtt ctctataaca tttagtaaaa taagaaggag aactaaaacc
    11581 aacttcataa cctatctctg ccactgtcat atccgacgag gcaagcagag aagcagcttt
    11641 cttcaaacga gctatacgaa gcagttcatt cggagaataa ttagtcagag atttaatctt
    11701 gcggtaaagt tgcacacgac ttaatcccat atccttaccc aaatcttcta cattcaaatt
    11761 tgaatctccc atctttgcct caatcagagc tttgaatttt tccacaaagt ctttatccat
    11821 atcacagaca tcctctttcg ccaacgtttg tccgtcacca aaaaactgtt tcaggcggcg
    11881 gtgtgaatct atcagattac gaacgcgtgc caatagtaat tgcgaactga aaggcttgga
    11941 gatataagaa tctgcaccac catcataccc ttgaattcgt tgttcatcca aagaacaagc
    12001 tgtcaatagg ataacaggaa tatgacaggt ttgtaattcg cttttcaagc gacgacaaca
    12061 ttcaattcca tccattccgg gcatcattac atcggagata atcaagtccg ggacatattt
    12121 catagcttta cgaatacctt ccgagccgtc tgcagcttct ataacagtat aatcagtgtg
    12181 aagcaatcca tgcacatata agcgaatatc agcgttatca tcaataatca gaacgcaagg
    12241 tttggaagag tcgtaacttt tttccaattc ctcttcttcg taagttaaag catcattcaa
    12301 gctcgaagaa ccggaataac cagaagttgc aggagttacg ggagccccag caacggcaga
    12361 ggttgcagca tcggtggagg ttacagaagt agcagggaca gagaatgccg gagagttttc
    12421 agaaacaaca gtctcgcaag tctgtacagg caaatcaacg gtaaagatag ttccttgctt
    12481 ttcatcactt tccactgtga tggtaccttt atgcaattcc acaaaagcct ttaccaatgc
    12541 cagtccaata cccgaaccgg catggtgcat atctatctta tagaaacggt cgaaaatatt
    12601 ccggatatgc tccgcagaaa tcattgagcc ggtattggca acagtaaagc gaatccaaca
    12661 atgatcgtct ttagtcaggg aagataagcg tacagttact tttccattct ccggagtaaa
    12721 tttgaaagcg ttggaaagga ggttgaaata gatgcgttcc aacttttcta catctgccaa
    12781 tgtgcggtaa tccgtatccg gcatataatc gaatgagaaa tgaatatgtt tcttccgggc
    12841 tgctgccatg aaagactcgt tccatccctc aaaagaagaa agaatgtcta acgaaatagg
    12901 agtatattcc atttttccat tctcgtattt acgaaaatcc agaatctgat tgacaagacg
    12961 caagaggata ttcacgtttc gctgaactaa caataacatt cggcgctgat cttcactcaa
    13021 agacgaatca gccagtaaat gctctaccgg gtcggcaact aatgtcagtg gagtacgaaa
    13081 atcgtgagat atatttgtga agaaaaccag cttggcatga gtcgcttctt ccagttgatg
    13141 agaaagctgg ataagctgat cccgctgttc ttcgagtttg tcacgctgtt cttcaagaat
    13201 atcccgttgc tcttcgagtt tatcgcgctg ttgctctact tgtttcttct gttcggacaa
    13261 ctctttattc aggcgattct tggaacggag ggatttatag actaccaaca acaatcccgc
    13321 tactaataaa agaataacca agccgccata catcacgacc tgctgcgtag ctacacgcga
    13381 cagataccca ccgatacgtc cgttcaatgt ttcaatcttc tgatccagtt ccgagatatg
    13441 ggtagtctga agttgcataa cgtgcgcgtt cgtgcggtct acaacggcag tattcatgac
    13501 cgtttcgcga ggataagact tcttctcaag aatattcatg gccagttgca tcactttgtc
    13561 cccattagtc ggataaataa aagttgcatc gagcacattg tcaagcacca attcaagccc
    13621 gtttcctttg ccgggcaggg catcaatgcc aacaaaaatc atttcctttt cacgtccggc
    13681 tttcttcgca gcctgatagg ctcccggagc gatacggtcg ttatgtgcat acaccgcatc
    13741 aatcttcgga tgacggtgaa gcatactatc catttccact tctgccggtt cacgttccca
    13801 ggcagcatcc gctttatcaa tcagtttgat atccggataa ttgctgatag cggccataaa
    13861 tccctgatgg cgctccatag caggggtgga accacccagt ccggtaagct ccactacatt
    13921 ccctttccct ttcagacttg atgcgatata atttcctacc gcacgaccta tttcataatt
    13981 atcggcacca atataggcag tatatttatc agaaagtatc ttccggtcta caagaatgac
    14041 aggtattcct ttctgatagg cctcctccac aattggagtc atgggagccg cttcattggc
    14101 ggaaattatc agtaaatcaa ctcctttatc tataaaataa tgaacatctt ccgcctgctt
    14161 acggttatca tccgccgccg aacggatttc aaccgacact ccatcataaa acatcgcttc
    14221 gcgaagaatc tcatcattca tcttgtgcct ccaagagtca tcgctacatt gggccacccc
    14281 aatacggaaa cgaggcgcat cctgccgaca ggccgccaag cccaaaagac aaagcaagac
    14341 tgttatccac ttcgtatatt tcatcgcttc aatcattccc tttctttcgt atatcttttg
    14401 tatttctttc tgtaatccaa atttctctcc ccgcattatt tgcattcacc accgggaaat
    14461 acatcagttc cactttcaca gggttcagcg tatattttcc agtaaagcgt ggaagcaaag
    14521 gaaccgtaaa ctgataagta cctaccggta atttttcgct aaagataaca gttttctctt
    14581 taaaatactc acgatatact tcagaacggg agaaattaac aggttttgag gcataactac
    14641 aacctgccgg aacaggaact tcgagcatca catattgcgc accctcctgt ttcacctgca
    14701 aggtaactgt caatgtaaca ggtacacccg ccaccaaaga gtctttttcc aaagtcacct
    14761 ccaccttgaa agcatcactc tgacgagcat tcatcacacg cttcattgaa tagacactat
    14821 acaataaagg ctcttttccc gtttttgaaa taagcagact gtcgcctgct gtcagccggg
    14881 catgataagg aaattccgta attcgttgat gatccttacc gctcacagac accgacgttc
    14941 ctgacatccc tccggaacct gccagcaaat cggtcagaac agttgccaca gccgaagaag
    15001 cctgatacgt attccatccg cgctccttag tccgcaaaat atacaattgc atattttctt
    15061 tcaacttaca cagggaaggg tcatttttaa taatccggta ggctatcaat gtatttatca
    15121 tctgatttcc ctcccaataa taagtacgcc gtccgtcgtc acagtaaaca ccttccagca
    15181 tatccttttt cagataagga cgtacgctat cacccacatt caccgaatcc acctgttgct
    15241 tgatttccca gagaagcagc ttctctttca agtatgaaag aggacgataa tacttgtttc
    15301 tatttgccaa cgagtcttct ttctgttcca attgccggac gaaaggttcc aataatctga
    15361 ctgccgaaga ataatccgcc tctactttcc actcatgcag agcatgaagt atttctatat
    15421 cttccagttt cattcctcga taaggacgcg tatgagcata ctccactttc aaaccattca
    15481 gattcaactc cacaggataa cctgcatctt gcgccatctt caaagcccgc agaatatgcg
    15541 cagacatcca gaaagaagta ttttcagagt tcccccacca cgaccataac tgatgtttgt
    15601 tctgatgatt cgtcagtcga tggatgatag gtcgaattgc tttatctact ttcacctttt
    15661 cacccttact ctgcatatac tgttggtaag ccaacaaacc ggttaacttg gatgccagct
    15721 gctcattgca caaatatttg tatcctgtca agtaattcac tgattcttta tagatgtcca
    15781 actgattgtc agtgatactc accatcactt cttcatcctc gccggattgc actttgaccg
    15841 tctttgcatc ggacagaata cccaatgtgc cctccgccaa ttcagttccc tgtggcagta
    15901 tcggaatcgt atattcctct ccatcctgat agccatcgtc gcgagtgaaa agatagctga
    15961 tggtcacgct atcggcatga actgcctgca tcggcactgt ttcatgaaat ccctccatga
    16021 aactcacttc ctgccgtttc aacgtatccg ttccgacgca gaactgtgtc tttccggcta
    16081 tgtgctgccc atccagataa ttgcggatag tcccgaccac cgtactctga tccccctcca
    16141 ccaagaagcg gggagttttc aactccgcca tcaacggttt gtaagagcgg acgaaacgtc
    16201 ggaaagtacc cgtctgcaaa cgacggttca tgccataaac gacagtt
//
