LOCUS       c00171_gnlPro..        15399 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|POGBOIJE_214.
ACCESSION   c00171_gnlPro..
VERSION     c00171_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 07:14:45
            Original ID  :: gnl|Prokka|POGBOIJE_214
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15399
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15399
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[542:5399]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      543..5399
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..15399
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15399
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             96..458
                     /locus_tag="ctg171_1"
                     /transl_table=11
                     /translation="MVQVRIKRVYEDFSETDGYRVLVDKLWPRGIRKEWLKYDYWAKDI
                     TPSAALRRWFHEDIPGHWSDFVVMYQKELEASQAVADFLTLIKPHPVITLLYASKEPVY
                     NHARILRDYLEMHLKE"
     CDS             543..1775
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg171_2"
                     /sec_met_domain="HBT (E-value: 2.1e-17, bitscore: 53.0,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDAKEISKRTLAALLKVQQMGVRIVLASGR
                     PTYGLMPLAKSLELGNYGGFILSYNGCQIINAQNGEILFERRINPEMLPYLEKKARKNN
                     FALFTYHDDTIITDTPENEHIQNEARLNNLKVIKEEEFSVAIDFAPCKCMLVSDDEEAL
                     VSLEGHWKRRLNGALDVFRSEPYFLEVVPCAIDKANTLGALLEELDVKREEVIAIGDGV
                     CDVTMIQLAGLGVAMGHSQDSVKVCADYVTASNEEDGVALAVEKAIIAEVRATEIPLDQ
                     LNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFGILHGGATLALGETVAGLGS
                     MILCQPDEIVVGMQVSGNHISSAHEGDTVRAVATIVHKGRSSHVWNVDVFTSTNKLVSS
                     IRVVNSVMKKR"
     CDS             1772..2884
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg171_3"
                     /sec_met_domain="Chorismate_bind (E-value: 1.2e-58,
                     bitscore: 188.3, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDEKSNLTTIDALILRKQPFAVYRVPGEKYPRLLTEDVGAVRLI
                     YDLKELNGQRGFVIAPFRVDKSCPIVLIQSDRTGRPLPMEIVADEEQVLQSYPEESFHT
                     LCTGKYATCFHTFIEALRDATFDKLVLSRSLTIRKNPEFSPSAVFRAACQRYIHSYIYL
                     CYTPQTGVWLGSTPEIILSGEKNEWNTVALAGTQPLQNGKLPQVWDDKNRQEQDYVASY
                     IRRQLLSLGIRSTESGPYPAYAGALSHLKTDFHFSLKDNKNLGDLLKVLHPTPAVCGLP
                     KEEAYRFILENEGYDRKYYSGFIGWLDPEGRTDLYVNLRCMHIEDEQLTLYAGGGLLAS
                     SELNDEWQETEKKLQTMRRILVSAPIMMNH"
     CDS             2904..4571
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg171_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2e-08, bitscore:
                     23.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLEAHGITKVVLCPGSRNAPLVHTLSTHPGFT
                     CYAMTDERSAGYFAIGLALNGGHPAAVCCTSGTALLNLHPAVAEAYYQNIPLVVISADR
                     PAAWIGQMAGQTLPQPGVFQTLVKKSVNLPEIQTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINIPISEPLFQFTAESLPEVRVITRYQGLNVYDRDYNDLIERLNRYQKRMVIVGQMN
                     LIYLFEKRHTKLLYKHFVWLTEHIGNQTVPGIPVKNFDAALYAMPEEKIGQMTPELLIT
                     YGGHVVSKRLKKYLRQHPPKEHWHVSADGEVVDLYGSLTTVIEMDPFEFLEKIAPLLDN
                     RVPEYPRVWENYCKTIPEPEFGYSEMSAIGALIKALPESCALHLANSSVIRYAQLYQVP
                     STIEVCCNRGTSGIEGSLSTAVGYAAGSDKLNFIAIGDLSFFYDMNALWNINVRPNLRI
                     LLLNNGGGEIFHTLPGLDMSGTSHKYITAVHKTSAKGWAEERGFLYQRVENEEQLAEAM
                     KTFTQPEAMEQPVLMEVFSNKNKDARILKDYYHQLKQK"
     CDS             4575..5399
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg171_5"
                     /sec_met_domain="ECH_1 (E-value: 2.1e-82, bitscore: 265.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQREWTTIREYEDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKKYPKFP"
     CDS             5403..6428
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg171_6"
                     /sec_met_domain="MR_MLE_C (E-value: 1.2e-29, bitscore:
                     93.1, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDCKIDIIPRVLHFKQPAGTSRGTYTTRKVWYLHFTAPEFPNWVG
                     IGECAPLPNLSCDDLPDYEEVLAKICRQVENQGGKLDMEALCKYPSILFGLETAIRHFF
                     EGSWALWDTPFSRGEAGIPINGLIWMGDFNRMLAQIEKKMEAGFRCIKLKIGAINFEEE
                     LALLQHIRSHYSFKEIELRVDANGAFSPTDAMEKLKRLSELDLHSIEQPIRAGQWEEMA
                     RLTSESPLPIALDEELIGYNTWEEKQRLLSAIRPQYIIIKPSLHGGLAGGEEWIAEAEK
                     LNIGWWITSALESNIGLNAIAQWCATFQNLLPQGLGTGLLFTDNVEMPLEIRKDCLWFC
                     K"
     CDS             6425..7531
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 53.1; E-value:
                     6.4e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg171_7"
                     /sec_met_domain="AMP-binding (E-value: 1.2e-17, bitscore:
                     53.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMIFDRQKQRLLLEGKEYTPGDIHGLVAEGEGNHPSAIWDLYLFL
                     NEWFNDDPVITVHTSGSTGAPKELLVRKDQMIQSARLTCEFLDLKQGETALLCMNLRYI
                     GAMMVVVRSLIAGLNLIVRRASGHPLADVDTPLRFAAMVPLQVYNTFQIPEEKEKLKQT
                     EILIIGGGAVDKALEEEIRNLPNAVYSTYGMTETLSHIALRRLNGAVASDRYYPFSSVE
                     LSLSSEDTLMINAPLVCDETLQTNDIARIYPDGSFTILGRKDNVINSGGIKIQAEEIEK
                     LLQSFIPVPFVITSVPDQRLGQAVTLLIEGQMEISALGTKLESVLAPYYRPKYIYQVNH
                     IPQTGNGKINRKECRVLAESLQLLGRQE"
     CDS             complement(7505..8074)
                     /locus_tag="ctg171_8"
                     /transl_table=11
                     /translation="MKISFSRQTKERAFKQLYEDYYAPFCLYAKRFVDDKEVREDIVSD
                     VFTSLWDKLDTDSFDLQSETALGYIKMCVKNSCLNFLKHQEYEWSYAENIQKKAPLYET
                     ETDSVYTLDELYRMLYETLNKLPENYRTVFMKSFFEGKTHAEIAEEMNLSVKSINRYKQ
                     KTMELLRNELKDYLPLFLLFLSPEQL"
     CDS             8299..9222
                     /locus_tag="ctg171_9"
                     /transl_table=11
                     /translation="MENMNPESLLRKAQALGEDIKEMESIDVMGAYQQAQTQIKTNRRR
                     SMYNQLMRYAAFLTIPLLLSSLILGYLYWGATDTEEKYAEVMAATGSVIRYELPDHSVV
                     WLNSGSTLRYPTVFKKDNRNVELKGEAYFEVEADRKRPFYVNTPAGLSVYVYGTKFNVN
                     AYEDDNSIETVLEKGKVNVISPDGKTTVQLAPGERLLYNKVDQKLLKGKVDVYEKVAWK
                     DGKLIFRNAELGEIFKRLARHFNVDIQFNNISGKEYKYRATFRNETLPQILDYLAKSAA
                     LKWRTEEAVQQADDTFTKKKIIVDLY"
     CDS             9472..12771
                     /locus_tag="ctg171_10"
                     /transl_table=11
                     /translation="MRISLALLFAVVLQLSAENGYAQRTHVAISMNNVSVEQVLNKIEE
                     ASDYVFLYNDKTIQKNRIVSVRNKSGKILDILDDIFKGTDITYTVVDKQIILSTNKMQL
                     VQQEGQIQIKGVVKDAGGDPLIGVNVKVKDSTVGTITDINGNFTLQTRKGDILEISYVG
                     YATKTVKVQNAQVLNIVLTEDTEVLNEVVVTALGIKKEAKSLSYNVQQVSNAEITRIAD
                     ANFVNNLNGKVAGVTINSSSAGVGGSSRVVMRGTKSLNGNNNALYVVDGIPMSDMSAAS
                     TQPTDSYEGAGQSGDPISGLNPEDIESISVLSGPSAAALYGSAAANGVVMITTKKGREG
                     RTSVSISNNTTFSAPLVLPEFQNTYGQTEVGSYYSWGSKLNTPSSYDPKDFFQTGVNVT
                     NAASLSTGTDKNQTYLSLGTTNAKGIIHNNDYERYNVTVRNVAKMLKDKLTLDLSFMLS
                     SVKEQNMTSQGLYYNPLVPLYLFPAGDDFSKVQAYQRYDSERNLLTQYWPYSTSLALQN
                     PYWITEHIKIPNHKNRYMATASAKYEFADWINVTARAKMDRNNERRERMYDAGTNTLFA
                     SKYGYYSKSNIENQQIYGELLLNINKYFVDNTLNVTANVGGNFENNDYQSDYFGGKLKS
                     VANLFTFGNVDTSEKNLANQYGYHLKKRAIFGSAQIGYKSMAYLDVTARNDWSSTFKGT
                     NTGSFFYPSIGLSGIITDIFRCSTDIMPYMKVRISYSEVGNSPDVFLAIPTYALVDGVP
                     VTQSRRPNPNLKPERTKSWEAGFNFVFFKNRLRLDGSIYQSRTYNQFFERTLSSTTGYK
                     SEVVNGGRVDNKGIELSLRFEDKWGNFGWSSYLTYSLNRNKVVELLRNYEDPYTHELTS
                     LDRIDMGGTSMYKMILTEGGSIGDIYVNTLRTDEHGAIYVHPSDQVVVTQPDEFVKAGN
                     SAPKYNLGWGNTFSYKGLSLGFLFTARVGGVVVSQTQATMDAYGSSKATAIARDNGGAI
                     VNGRPIGAEDYYTKIGGAGAQGGIGSMYTYSATNVRLAELSLGYDIPINKYVDWIKGLN
                     VSFIGKNLFFLYRKAPFDPELTASTGTYFQGIDMFMSPSLRNLGFSVKVNF"
     CDS             12796..14391
                     /locus_tag="ctg171_11"
                     /transl_table=11
                     /translation="MILNKILSWNKLSILGISLMLLNNISCIDYEDNVNPNEVTEEMME
                     VDNLKTGAFFSQMLRRVVIINDGDKLDSDYQIAQNLSHDLYSGYIAATLGSTNHNGQYN
                     FQEQWVNATFDYAYTGIMAPWQSIHKIATEQELPEVDALATIVKVEGMHRIADTFGPIP
                     YVNYGSSSLYDALDLVYNKFFEELDNAIEVLSNYVNGNVDAKLMSDYDCVYGGDVEKWV
                     KFANTLRLRLAIRVSYANPTLAEAQAKKSMENMFGFIESKAERAELSHNSLEYHHPLHE
                     IAYNFNSGDCRPGATIVAYLNGLNDSRISSYFTAADDGEYHGVRIGITTSNMSNYQGNK
                     ISNLNINRASTPVVWMTAAESFFLRAEGALRGWDMGGTAKSFYEQGVRMSFEENNAAGV
                     DDYLADHTSTPGAFADNVGSDNYTFSSRVTPAWDDNAGFEAQLERIITQKWIANYPDGP
                     EGWSEYRRTGYPEVIPVVRNSSNGTIDTQLQVRRLPYTRDEKINNASGVASGISALGGQ
                     DTGGTKLWWDKKSR"
     CDS             14434..15375
                     /locus_tag="ctg171_12"
                     /transl_table=11
                     /translation="MKTKITGLLTFLIGTFFFYSCDTDVEALEIQKLKTYDEQYFENLR
                     AFKKSDHEISYAYYEAWSPIEGVTGYKDPASWGERMVGLPDSIDIVNLWMGIPTAETHP
                     IAYADMQYCQRKLGTRFVMHADASHYRHQFTVDGVDYDLSQNKDDEAMAAYAKWIVNQV
                     LEPGLDGVDVDWEGWSGSDLVRLIKELGKYFGPEGEQPDKLLIVDYFSGTPPTDIIPYC
                     DYIVQQAYSDQVGFLTQPSNFPPEKMIYCESFGVFYADGGQLMNYARWEPSKGRKGGCG
                     VFYLGRNYYSSSGIPYNEFREAIQIMNPAVNE"
ORIGIN
        1 gaaagcgcag gaatccttag gttgattttg gctttttcgt taaacaattt tccgttttat
       61 cggtttattc ttatgataac taaatataaa cggaaatggt gcaagttagg ataaagcgag
      121 tgtacgaaga cttttcagag acagacggat atcgggtgct ggtagataaa ctctggccac
      181 gtggaatcag gaaagaatgg ttgaaatatg attactgggc aaaagatata acgccttccg
      241 cagcactgcg tagatggttt catgaagata ttccggggca ctggagcgac tttgtcgtaa
      301 tgtatcagaa ggaactggaa gcttctcagg ctgttgccga ttttctgact cttatcaaac
      361 cccatccggt gatcactttg ctttatgcat ccaaagaacc ggtctacaat catgcccgaa
      421 tccttcgcga ttatctggaa atgcatctga aagagtgaaa ttaaagtaat ttttatctct
      481 ttccgctttc agtcgttcac tcaatttcct acctttgtaa tctaaatcaa aatcgtgtgt
      541 ccatgaagta taaattatta gttcttgatg tagacggaac gcttctcaat gatgcaaaag
      601 aaattagtaa acgtacattg gccgctttgc tgaaagtaca gcaaatggga gtacgtatcg
      661 tgctggcatc cggcagacct acttacggtc tgatgccctt agccaaatcc cttgaactcg
      721 gaaattacgg aggttttatt ctttcttata atggttgcca gataattaat gctcaaaacg
      781 gagaaatact gtttgagcgg aggattaatc cggaaatgtt gccttatctg gaaaagaagg
      841 caagaaaaaa taatttcgca ctgttcactt accatgatga tacgatcatt actgacactc
      901 cggagaatga acatatccag aatgaagctc gcttgaataa tttgaaagtg atcaaggaag
      961 aggaattttc tgtagcaatt gattttgccc cgtgtaagtg tatgcttgtc agcgatgacg
     1021 aggaagcgtt ggttagtctg gaaggacact ggaagagacg gttgaacgga gctttggatg
     1081 ttttccgttc cgaaccttat tttctggaag tagtgccgtg tgcgattgat aaagccaaca
     1141 cattgggagc tttattggaa gaactggatg tgaagcgtga agaagtcatc gctataggag
     1201 acggtgtgtg cgatgtaacg atgattcagc tggcaggact gggagtggcg atggggcatt
     1261 cgcaggattc ggtaaaggtc tgtgcggatt atgtgacagc ttccaatgag gaagacggag
     1321 tggctctggc tgtcgaaaag gcgataatag cggaagttcg ggctacagag attcctttgg
     1381 accagttgaa tgcacaggcg cgtcacgcat tgatgggtaa tctgggtatc caatatacat
     1441 atgccgacga agaccgtgta gaggcgacga tgccggtaga tcaccgtacc cgtcagccgt
     1501 tcggtatttt gcacggtgga gctacgcttg cattgggaga aacagttgcc ggactcggct
     1561 cgatgattct ctgtcagccg gatgaaattg tggtaggaat gcaggtcagc ggaaatcata
     1621 tatcttctgc gcacgaaggt gatacagtac gtgcagtagc gacgattgta cacaaaggac
     1681 gttcctccca tgtatggaat gtggacgttt ttacttcaac caataaactg gtgtcctcta
     1741 tacgggtggt caacagtgtg atgaaaaaaa gatgattgac gaaaaaagta acttgacaac
     1801 tattgatgca ctcattctgc ggaaacagcc ctttgctgtt tatcgtgttc ccggggagaa
     1861 gtatcctcgt ctgttgactg aagatgtcgg agctgtccgc ctgatttacg atttgaaaga
     1921 actgaatgga caaagaggat ttgtgattgc tccgttccgt gtagataagt catgcccgat
     1981 tgtgttgata cagtccgaca ggactggacg gccgttgcct atggaaatcg tggcagacga
     2041 agagcaggtc ttgcaaagtt atccggagga atcttttcat accctttgta cagggaagta
     2101 tgcgacctgt tttcatacat ttattgaagc cttgcgtgat gctacctttg ataaactggt
     2161 gctttcccgt agtctcacta ttagaaagaa tccggagttt tccccttcag ctgtttttcg
     2221 tgcagcttgt caacgttata ttcattctta tatctatctg tgttatactc ctcagacggg
     2281 cgtgtggctg ggaagtaccc ccgaaattat attgtcgggc gaaaaaaatg aatggaatac
     2341 agttgccttg gcaggaactc aacctttgca gaatggtaaa cttccgcaag tatgggatga
     2401 caaaaaccgt caggagcagg attatgtggc gtcctatatc cgtcggcagc ttctttcgct
     2461 gggcattcgc tctacagaga gcgggcctta tccggcatat gccggcgccc tgtcacatct
     2521 gaaaactgat tttcatttct ctttgaaaga taataaaaat ctgggagacc ttctgaaagt
     2581 cctgcatccg actcctgccg tgtgcggact gcctaaagaa gaagcctacc ggttcatttt
     2641 ggaaaatgaa gggtacgatc gtaagtatta ttccggtttt atcggttggc tcgatccgga
     2701 gggacgcaca gatttgtatg tgaatctgcg ttgcatgcac attgaagacg agcaactgac
     2761 actgtatgcc ggtggcggat tgttagcctc ttcagagttg aatgatgaat ggcaggaaac
     2821 ggaaaagaaa ttgcagacaa tgaggcgtat tcttgtgtct gctccaataa tgatgaatca
     2881 ttaacaagct aatcactatt aatatgtatt cggacaagaa aaatatactc cagttggtcg
     2941 cgttgcttga ggcgcatgga attacgaaag tagtgttatg tcccggtagc cgtaatgcac
     3001 ctcttgtgca tacgctgtct actcatccgg gttttacttg ttatgctatg acggatgagc
     3061 ggagtgccgg ttattttgcg attggtcttg cgctgaatgg cgggcatcct gctgccgttt
     3121 gctgtacttc cggtacagcg ttgctcaatc ttcatcctgc tgtggcagaa gcgtattatc
     3181 agaatatacc tttagttgtg atctctgccg atcggcctgc tgcctggatt ggacagatgg
     3241 cgggacagac attgccgcag cccggtgttt ttcagacatt ggtcaagaaa tcggtaaacc
     3301 ttccggagat tcagacagaa gaggatgaat ggtactgtaa ccgcttggtg aatgaagcat
     3361 tgctggaaac caaccatcat ggaaaaggtc cggtacatat taatattcct atatccgaac
     3421 ctttgttcca gtttacggcg gagtcgcttc ccgaagtacg tgttatcacg cgctatcagg
     3481 gtctgaatgt atacgaccgg gattacaatg acctgatcga acgcttgaac agatatcaga
     3541 agcggatggt tattgtcgga cagatgaact tgatttactt gtttgagaaa cggcatacca
     3601 aattgttata taaacatttc gtgtggctga ccgagcacat cggtaatcag acagtacccg
     3661 gtattccggt gaagaatttt gatgcggcgc tttatgcgat gcccgaagag aaaatcggcc
     3721 agatgactcc cgaactactg attacttatg gcggacatgt ggtttccaag cggttgaaaa
     3781 aatatcttcg gcagcatccg cctaaagaac actggcatgt gtctgctgat ggagaagtgg
     3841 ttgaccttta cggttctctg actaccgtca tcgaaatgga cccgtttgag tttctggaga
     3901 aaatagctcc attgctggat aaccgcgtgc cggagtatcc ccgtgtatgg gagaattatt
     3961 gcaagaccat tcccgaaccg gagttcggat attcggaaat gtcggctatc ggtgctttga
     4021 taaaagcatt gccggaatca tgtgcattgc atctggcaaa tagttctgtt atccgctatg
     4081 ctcagttata ccaggttcct tctacgattg aggtatgctg taatcggggt acaagcggca
     4141 tcgaaggctc gttgtccacg gcagtgggat atgctgccgg ttcggataaa ctaaatttta
     4201 tagctatagg tgaccttagt ttcttttatg atatgaatgc tttgtggaat atcaatgtcc
     4261 gtcctaatct acgcattctt ttgctgaata acggaggagg ggagattttc catacattac
     4321 ccggactgga tatgtcgggt acatcgcaca agtatattac agccgttcac aagacatctg
     4381 ccaaaggatg ggcggaagaa cgcggattcc tttatcaacg ggtagagaat gaagaacagc
     4441 ttgccgaagc gatgaaaacc ttcacacaac cggaagccat ggaacaaccg gttctgatgg
     4501 aagtattcag caataaaaat aaagatgcac gtatactgaa agattattat catcaactaa
     4561 aacaaaaata gattatgtca acacaaagag aatggacaac catcagagaa tacgaagata
     4621 tcctctttga ttactataat gggattgccc gcatcaccat taaccgtgaa cgctatcgaa
     4681 atgcatttac tccgactaca acggctgaaa tgagtgacgc attgcgcatt tgccgggaag
     4741 aagcggatat tgatgtgatc gtgattacgg gagctggtga caaggctttc tgttcgggcg
     4801 gtgaccagaa tgtgaaaggg cgtggcggct atatcggcaa ggacggtgtt ccccgtctga
     4861 gtgttctgga tgtacagaaa caaatccgca gcattccgaa accggtaatt gctgccgtaa
     4921 atggatttgc cattggtggc ggacacgtgc ttcatgtagt ttgcgattta tcgattgctt
     4981 cggagaatgc gatcttcgga cagaccggtc ctcgcgtagg tagctttgat gcaggtttcg
     5041 gagcctctta tctggctcgt gtcgtcggtc agaagaaggc acgtgagata tggttccttt
     5101 gccggaaata caatgcgcag gaagcgttgg atatgggatt ggtgaataaa gtagttccat
     5161 tggagcaact ggaggatgag tatgtgcaat gggcggaaga aatgatgctg ctcagtccgt
     5221 tggccttgcg gatgattaaa gccggattga atgccgaact ggacggccag gcaggtattc
     5281 aggagctggc aggggatgcg accttgcttt actatctgac ggatgaggct caggaaggaa
     5341 agaatgcatt tctggagaaa cgtaaaccta actttaagaa atatccgaag ttcccttaaa
     5401 caatggattg caaaatagac attattccgc gggtgcttca tttcaagcag ccggccggaa
     5461 cttcacgagg cacatacaca acgcgaaaag tctggtatct tcattttact gctcccgaat
     5521 ttcccaattg ggtagggatc ggggagtgcg ctcctctgcc aaatcttagc tgtgatgatc
     5581 ttcccgatta cgaggaagtg ctggctaaaa tctgccggca ggtagagaat cagggaggta
     5641 agctggacat ggaagctcta tgcaagtacc cttccatcct ttttggcttg gagacagcca
     5701 ttcgtcactt ttttgaagga agctgggctt tgtgggatac acccttctca cgtggggaag
     5761 caggtattcc gataaacggg cttatctgga tgggtgactt caatagaatg cttgctcaga
     5821 tagagaagaa gatggaggcg ggattccgct gtataaagtt gaagatcggt gccatcaact
     5881 ttgaagaaga actggcttta ctccaacata tccgctctca ctattctttt aaagaaatag
     5941 aattgcgtgt agatgccaac ggagcattct cgccaacaga tgcgatggag aaattgaaac
     6001 gcttgtccga actggactta cattcgatag aacagcccat tcgtgccgga caatgggaag
     6061 aaatggcacg tcttacttcc gaatctcctt tgccgatagc tttggatgag gaactgatag
     6121 gctataatac ctgggaagaa aagcaaaggc tgctttcggc tatccgtccg caatatatta
     6181 ttatcaaacc ttctcttcat ggtggattag ccggtggcga ggagtggatt gcggaagcgg
     6241 agaaactgaa tatcggctgg tggataactt ctgctctgga gtctaatatc ggtctgaatg
     6301 ctatcgcaca atggtgcgcc acttttcaga atctattgcc tcaagggtta ggcaccggat
     6361 tactttttac agataatgta gagatgcctc ttgaaatcag aaaagattgt ttgtggtttt
     6421 gtaaatgatg atattcgacc gacaaaaaca gcgtttgttg ctggagggaa aggaatatac
     6481 tccgggcgat atacatggcc ttgtagcaga aggtgaggga aaccaccctt ctgctatatg
     6541 ggacttgtat ctttttctaa acgaatggtt taatgatgat cctgtgatca ctgtacatac
     6601 ttccggttct acgggggcac ctaaagaatt gcttgttcgc aaagatcaga tgatacagag
     6661 tgcacgcctg acttgtgagt ttctggattt aaagcagggt gaaacggcat tattgtgtat
     6721 gaaccttcgc tatatcggag cgatgatggt agttgtccgt tctttgattg ccgggttgaa
     6781 tcttatagta cgtcgggctt ccggccatcc attggcggat gtggacactc ctttaaggtt
     6841 tgcggctatg gtgcctttgc aggtgtataa tacgtttcag atacccgaag agaaagagaa
     6901 attaaagcaa acggagattt taattatagg aggcggagca gttgacaaag ctttggagga
     6961 agaaatcaga aatctgccca atgctgttta ttcaacttat gggatgacgg aaacactttc
     7021 tcacatcgct ctccgccgtc tgaatggtgc agtggcttcc gatcgttatt atcctttttc
     7081 atccgtagag ttatctttgt cttcagaaga tacattgatg attaatgctc cgcttgtctg
     7141 tgatgaaact ctgcagacga atgatattgc ccgcatttat ccggacggca gttttacgat
     7201 tttgggacga aaggataatg taatcaatag cggaggtatt aaaattcagg cagaagagat
     7261 cgaaaagtta cttcagtcgt ttattcctgt accgtttgta atcacttccg ttccggatca
     7321 gcgtttgggg caggctgtta ctttgttgat agaagggcag atggaaataa gtgcgctagg
     7381 gactaaattg gaatcagtct tagcacctta ttatcgtcct aaatatattt atcaggtaaa
     7441 tcatattcct caaacgggaa atgggaagat taatcgtaaa gagtgccgtg ttttagcaga
     7501 gagcttacag ttgctcggga gacaggaata ataaaaacag cgggaggtaa tctttcaact
     7561 cgttccgcag gagttccatt gttttttgtt tataccgatt aatggatttt acgctgagat
     7621 tcatttcttc ggcaatttcc gcatgtgttt tgccttcaaa gaaactcttc ataaatacgg
     7681 tgcgatagtt ttccggaagc ttatttaatg tttcgtatag cattcggtat aactcatcaa
     7741 gtgtatatac actatctgtt tctgtttcat atagaggagc tttcttttgg atattttcgg
     7801 cataactcca ttcatactcc tgatgtttca gaaagttcaa acagctgttt tttacacaca
     7861 tttttatata tcccaatgct gtctctgatt gcaaatcgaa agagtcggta tccaacttgt
     7921 cccataggga ggtgaataca tccgaaacaa tgtcctcgcg gacttcttta tcatctacaa
     7981 atctttttgc atacaggcag aaaggggcat aataatcctc gtaaagttgt ttgaaagctc
     8041 tttctttagt ctgtctggaa aaagatattt tcattatttt gagattctgt agtttttcat
     8101 tttactgcaa atatataata agaaaatcag catttcctaa aattttcttt ctttttttgt
     8161 ttttggtatg aagctgtgga aaataagata gcttaaaaaa taaaataaaa aaaagtatgt
     8221 tatacctgtc ccttttcgat tacctcagtt gtactattag tgtaattgca attaaaagat
     8281 aagattttga aagagaatat ggaaaatatg aatccggaat cattgctccg aaaagcgcag
     8341 gcattaggag aggatattaa ggaaatggag tctattgatg taatgggtgc ctatcaacaa
     8401 gcacagaccc aaataaagac aaacagaaga aggagtatgt ataatcagtt gatgcgttat
     8461 gctgcattct tgactatacc tttattactt tcttctttga ttttgggata tttatattgg
     8521 ggagcaacgg atactgaaga gaagtatgca gaagtcatgg cggctacagg ttcagtcatt
     8581 cgttacgaac ttcctgacca ttcggttgtc tggttaaact ccggtagtac tttacgttat
     8641 cctaccgttt ttaagaaaga taatcgtaat gttgaattaa aaggtgaagc ctattttgaa
     8701 gtagaagcgg acaggaaacg gcctttttac gtcaatactc ctgccgggtt aagtgtctat
     8761 gtgtacggaa ccaaatttaa tgtgaatgct tacgaagatg ataatagtat agaaacggta
     8821 ttagaaaagg gtaaagtaaa cgttatttca ccggacggaa aaacaacagt tcagttagct
     8881 ccaggagaac gattgcttta taataaggta gatcagaaat tgttgaaggg aaaagtggat
     8941 gtttatgaaa aggtggcatg gaaagacggt aagttgatat tccgcaatgc cgagttgggt
     9001 gaaatattca aacggctggc acggcatttt aatgtagata ttcagtttaa taatatatcg
     9061 ggaaaagaat ataaatatcg tgcgaccttc cgtaatgaaa cactgccaca gatattggat
     9121 tatctggcta agtctgctgc cttgaagtgg agaactgagg aggcggtaca acaggcagat
     9181 gatacattca caaagaaaaa gataatagta gatttatatt agtaaccata aaaatgagaa
     9241 tagcctatga gataacacaa agatcgtaaa aaaaggaaga aagctgctac caacagctgt
     9301 cttcccccaa tttttcagat tcgcggtaag gagtcttgca aacgctaacc ggaatcaaac
     9361 cacagttcat tatagtaata aactttagtt aaccgcaaat gtatgaaaaa aaatcattca
     9421 tttattgcat tatatcctaa atatgcttta aatctaaaac tacctttagt tatgaggatt
     9481 agtctggcac tactttttgc agtcgtttta caactatctg cagagaatgg ctatgctcaa
     9541 cggacgcatg ttgccatttc tatgaacaat gtatctgtag aacaggtact gaataaaata
     9601 gaagaagctt ccgattatgt tttcctttac aatgacaaaa cgattcagaa gaatcgtatt
     9661 gtttctgtga gaaataaatc aggtaagatt ctggatattc tagatgatat ttttaagggg
     9721 accgatatta cgtataccgt agttgacaag cagattattt tatcgactaa taaaatgcaa
     9781 cttgttcagc aggaaggaca aatccaaata aaaggagttg tgaaagatgc tggcggagat
     9841 cccttgatcg gtgtgaatgt gaaagtgaaa gattctacgg tcggtactat caccgatata
     9901 aacggaaact ttacgctaca gaccaggaaa ggagatattc tggaaatttc ttatgtggga
     9961 tatgccacga aaacagtaaa ggtacagaat gcccaagttc tgaatattgt gctgacagaa
    10021 gatacagaag tactgaatga agtcgttgtt actgcattgg gtatcaagaa ggaagctaaa
    10081 tctttgtcat acaatgtaca gcaagtaagc aatgccgaga ttacacgcat tgcagatgcc
    10141 aacttcgtca ataatctgaa cggtaaagtt gcgggtgtta caattaactc atcttcagct
    10201 ggtgtcggtg gctcttcacg tgtagtgatg cgtggaacca aatcattgaa tggtaataac
    10261 aatgctcttt atgtggttga tggtatcccg atgagtgata tgagtgccgc ttctacacag
    10321 cctacggact catacgaagg tgccggtcag tccggtgatc ctatttccgg tctgaatccc
    10381 gaggatatag agagtatctc tgttttgagt ggaccgtcag ctgcagctct ttacggtagt
    10441 gccgctgcca atggtgttgt gatgattact actaaaaaag gtagggaagg acgtacttca
    10501 gtcagcatat ccaataatac gactttctcc gctcctcttg tcttgcccga atttcaaaat
    10561 acttatgggc agacagaagt gggtagttac tacagctggg gcagtaaatt gaatacgccg
    10621 agcagctatg atcctaaaga cttctttcag acaggtgtga atgtaacaaa tgctgccagt
    10681 ctttctacag gtactgacaa gaatcagact tacttatctt taggtactac caatgccaaa
    10741 ggtattatcc ataataatga ctacgaacgt tacaatgtca ctgtccgtaa tgttgccaag
    10801 atgctgaaag ataagctgac tcttgacctg agttttatgc ttagctctgt aaaagaacaa
    10861 aatatgacct ctcagggact ttattataac ccgttagtac ctctttatct atttcctgcg
    10921 ggagatgatt tctccaaagt acaggcatat cagcggtatg attcggaacg aaatttactg
    10981 actcagtact ggccttacag cacaagtctg gctttacaga atccatactg gattaccgag
    11041 catattaaaa tacctaatca taagaaccgt tatatggcaa ctgcatcggc aaaatatgaa
    11101 tttgctgact ggattaatgt aacagcccgt gccaaaatgg accgcaacaa cgaacgccgt
    11161 gagcgcatgt atgatgccgg aacaaatact ttgtttgctt ctaaatacgg ttattactcc
    11221 aagagtaata tcgagaatca acagatatac ggtgaattat tgctgaatat taataagtac
    11281 tttgtcgata ataccctaaa tgtaacagct aatgtgggtg ggaactttga aaacaatgat
    11341 tatcagtctg attatttcgg aggcaaactg aagtcggtag ccaacctctt tacttttggc
    11401 aacgtggata cttcagagaa gaatctggcc aaccaatatg gctatcattt gaaaaaacgc
    11461 gccatattcg gtagtgctca gatcggttac aagtctatgg cttatctgga tgtgacggct
    11521 cgtaacgact ggtcatctac cttcaaaggg acgaataccg gttctttctt ctatccgtct
    11581 atcggtcttt cggggattat cacagatata ttccgttgca gtacggatat tatgccatac
    11641 atgaaagtac gtatttctta ttcggaagta ggtaattcac cggatgtatt tctggctatt
    11701 ccgacttatg cgttggttga tggcgttcct gttactcagt cccgacgtcc taaccccaat
    11761 ctgaagccgg aacgtaccaa atcatgggaa gccggattta actttgtctt cttcaagaac
    11821 cgtttgagat tggatggatc tatctatcag tcacgtacct acaatcagtt ctttgaacgt
    11881 accctttctt ctactaccgg ctataaatcg gaagtagtca atggcggtcg tgtagataat
    11941 aaaggtatcg aattgtcttt gcgttttgag gacaaatggg gaaattttgg ctggagttcg
    12001 tatctgacct attcattgaa ccgaaataaa gtggtggaat tgctgcgcaa ctatgaagat
    12061 ccttatacgc acgaacttac ttctttggat agaattgata tgggcgggac aagtatgtat
    12121 aaaatgatac tgacagaagg cggatctatc ggcgatattt atgtgaatac gcttcgcacg
    12181 gacgaacatg gagctatcta tgtccatcct tcggaccagg ttgtagttac tcagcctgat
    12241 gaatttgtaa aggctggtaa tagtgctcct aagtataacc tcggttgggg aaacacattc
    12301 agttacaaag ggctttcatt gggattcctg ttcacggcac gtgtcggtgg tgtagttgta
    12361 tcacagacac aggcgacgat ggacgcatac ggctcttcaa aggctacagc tattgcccgt
    12421 gataatggcg gagccattgt taacggtcgt ccaatcggtg cggaagatta ctatacgaaa
    12481 attggaggtg caggtgctca gggtggtatt ggttctatgt acacctacag tgcgactaat
    12541 gtccgtttgg ctgagttatc gttaggctat gatattccta tcaacaagta tgtggactgg
    12601 attaaggggt tgaacgtatc tttcatcggt aagaatctct ttttccttta tagaaaagct
    12661 ccgttcgatc cggaactgac agcaagtaca ggcacttact ttcaaggtat cgacatgttt
    12721 atgtcgccaa gtctgcgtaa tttgggattc tctgtgaaag ttaatttcta atcaaactta
    12781 taaattgtag aagatatgat attaaataaa atactatcat ggaacaaact ttccattctc
    12841 gggatatctt tgatgctatt aaataacatt tcgtgtatcg actatgagga taacgtaaat
    12901 ccgaatgaag tcaccgagga aatgatggaa gtagacaact tgaagacggg tgctttcttt
    12961 tcgcaaatgc tgcgtcgggt tgtaatcata aatgatggcg acaagctcga ctctgactat
    13021 cagattgctc agaacttatc gcatgacctt tattcgggct atattgccgc taccttagga
    13081 tctaccaatc ataacgggca gtataacttt caggaacaat gggtgaatgc cacttttgat
    13141 tatgcctata ccggaattat ggcaccatgg caaagtattc acaaaatagc cactgaacag
    13201 gaactgccgg aagttgacgc attggctacc atcgtaaagg tagaaggcat gcaccgtatt
    13261 gctgatacat ttggtcctat tccatatgta aactatggct cttccagctt atatgacgca
    13321 ttggatttgg tttataataa gttttttgaa gaactggata atgctatcga agtattgagc
    13381 aattatgtga acggaaatgt ggatgctaag ctgatgagtg actatgactg tgtatatggg
    13441 ggggacgtag agaagtgggt gaagttcgcc aacacactgc gtttgcgtct tgctatacgt
    13501 gtttcatatg cgaatcccac actggcagaa gcacaggcaa agaagtcgat ggaaaacatg
    13561 ttcggcttta tcgaaagtaa agcggaacgt gccgaacttt cgcataattc attggaatat
    13621 catcatccgt tgcacgagat tgcctataac ttcaattcgg gtgactgtcg tccgggtgct
    13681 accatcgtag cctatttgaa cggactgaat gattcgcgaa tcagctctta ttttacagca
    13741 gccgatgacg gtgaatatca tggcgtacgt attggtatca caacaagcaa tatgagcaat
    13801 tatcaaggca ataaaatctc taatctgaat attaaccgtg cttctactcc ggtagtatgg
    13861 atgacggctg ccgaatcgtt cttcctgcgt gccgaaggtg cattacgtgg ctgggatatg
    13921 ggtggaacgg ccaaatcatt ctatgagcaa ggtgtacgca tgtcgtttga ggagaataat
    13981 gccgccggtg tagacgatta tttggctgat catacttcga ctccgggtgc ttttgcagac
    14041 aatgtgggta gtgataatta tactttcagc agcagggtta ctcctgcatg ggatgataat
    14101 gccggatttg aagctcagtt ggaacgcatc attacacaga agtggattgc caattatccc
    14161 gacggtcccg aaggctggag tgaatatcgt cgtacaggct atccggaagt tattcctgta
    14221 gtaagaaaca gtagtaatgg tacgattgat acccagttac aagtccgccg tctgccttat
    14281 acacgcgacg agaagatcaa caatgctagc ggcgttgcca gtggtatatc ggctttgggt
    14341 ggtcaggata cgggtggaac taaactctgg tgggacaaaa aatcccgata acaggagaat
    14401 ggacattgtt taattctaaa aacactaatt acgatgaaaa caaaaataac aggtttactg
    14461 actttcctta tcggaacatt ctttttctat agttgtgata ccgatgtgga agcgttagaa
    14521 attcagaagc tgaaaacata tgacgagcag tattttgaga atctgcgtgc tttcaagaaa
    14581 agcgatcatg agataagtta tgcttattac gaagcgtggt caccgattga aggtgtgaca
    14641 ggctataaag atcccgcgtc gtggggtgaa cgtatggtag gactacctga cagtatagat
    14701 attgtaaatc tttggatggg aataccgaca gcagagacac atccgatagc atatgcggat
    14761 atgcaatact gccagcggaa attgggtaca cgttttgtca tgcatgccga tgcttctcat
    14821 tacagacacc agtttaccgt tgatggggtt gattatgatc ttagccagaa taaggacgat
    14881 gaagcgatgg ctgcatatgc aaaatggatt gtgaatcaag tgttggaacc gggacttgat
    14941 ggagtagacg ttgactggga aggttggagt ggttccgatt tggtcagatt gataaaggaa
    15001 cttggcaagt attttggtcc tgaaggcgaa cagccggata agttgcttat cgttgactac
    15061 tttagtggaa caccaccaac agacatcata ccttattgtg attatatcgt tcaacaggct
    15121 tatagtgatc aagtggggtt cttgactcaa cccagtaact ttccacccga gaagatgatt
    15181 tactgcgaat cgttcggagt attctatgcc gatgggggac aacttatgaa ctatgcacgt
    15241 tgggaaccgt cgaaaggccg taaaggcggt tgtggagtat tctacttagg aagaaattat
    15301 tattcttcat cgggtatacc ttataatgaa ttccgggagg ctattcagat aatgaatcct
    15361 gctgtaaatg agtaaacaat gaataaataa gaatcatga
//
