LOCUS       c00001_gnlPro..        16270 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KOAKFGKP_1.
ACCESSION   c00001_gnlPro..
VERSION     c00001_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 05:32:35
            Original ID  :: gnl|Prokka|KOAKFGKP_1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16270
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..99)
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MLPSLTSGCREPVHPGVRGGNMGVSGNKSTVPN"
     protocluster    1..16270
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3290:6270]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3291..6270
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..16270
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16270
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             complement(570..2135)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.1e-47, bitscore:
                     155.5, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDSAMKDQLSDIFSGLVSQYVFDIQVAPDHESRQELIDLLGDVA
                     SCSDHLSCSVADGEGLQFTIVKDGMPTGIRFRAVPNGHEFTSLLLAVLNSDGKGKNIPD
                     ESICARVRALNGPIKLTTYVSLTCTNCPDVVQALNVMATLNSRITHETVDGAINQKEVE
                     AMKVQGVPSVFADGKLINVGRSDLGELLSKLEAQYGINEGGVDNSVEKPVKNYDVLIVG
                     GGPAGAASAIYSARKGLNVAVIAERIGGQVKETVGIENLISVPQTTGKQLANDLLMHIN
                     DYPVDILEHRRVDKVELDGSAKLLTTSTGERFSAPALIVATGASWRKLNVPGEADYIGK
                     GVAFCPHCDGPFYKGKHVAVVGGGNSGIEAAIDLAGICSKVTVLEFMDELKADQVLQEK
                     AKSLPNVEVFLHSQSLEVLGNGDKVTGLRVKDRKTDAERVIDLDGIFVQIGLAANSGVF
                     RDVVETNKPGEIVIDAYCRTNVPGIYAAGDVSTVPYKQIIIAMGEGAKAALSAFEDRMR
                     GSIG"
     CDS             complement(2140..2706)
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MEPIINSQVPEFKVQAFQNGSFKTVSSEDIKGKWAIFFFYPADFT
                     FVCPTELVDMADKYGKFQEMGVEVYSVSTDSHFVHKAWHDASETIRKIKYPMLADPTGA
                     LSRAFGVMIEEEGMAYRGTFLVNPEGKIKIAEIHDNGIGRNADELLRKVEAAQFVASHP
                     NEVCPAKWKKGEATLKPSIDLVGKI"
     CDS             2983..3288
                     /locus_tag="ctg1_4"
                     /transl_table=11
                     /translation="MRRASLYNTFSASLLLVCNAWLSSCVSQIPLTKEKPVNNSTYQVE
                     YLFEHEGCKVYRFMDMGHYIYFTNCEGDVTSIESDSVRTVNRISRKPIIIKEQTLD"
     CDS             complement(3291..4022)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 73; E-value:
                     9.7e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_5"
                     /sec_met_domain="Radical_SAM (E-value: 8.1e-35, bitscore:
                     114.4, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LINMLGRIHSLESFGTVDGPGIRFVVFMQGCPLRCLYCHNPDTWE
                     VKRETPYLLEPEALLAEVLRYKNFIAKGGVTVTGGEPLLQPEFLKEFFRLCRENGIHTA
                     LDTSGYICSGKALEVLEQVDLVLLDIKTIDAGLHPRLTAVKLDNTLRFLDELEKRGIPV
                     WIRHVIVPGLTDDDEALSKLAEYISSYNVVQKAELLPYHTMGAYKYEAQGLDYKLKGVE
                     PLSAERLANAKAIFSKHGITV"
     CDS             complement(4030..6270)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_6"
                     /sec_met_domain="Gly_radical (E-value: 3.5e-45, bitscore:
                     146.7, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 6.3e-281, bitscore:
                     926.7, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFENENWAQFKGETWKKEINVRDFIQNNYKPYNGDDTFLVPSSE
                     KTKKVWNKLTEMFKVEREKGVYDAETKLPQGIDTYGPGYIDKENEVIVGLQTDAPLKRG
                     IFPKGGIRMVENSLEAYGYHLDPMTKEIFTKYRKTHNEGVFSAYTDEMIAARRSAIITG
                     LPDAYGRGRIIGDYRRVPLYGTQILIEEKKRFQKRLDIQELTEEIIQSREEITEQIKAL
                     KAFEKMCAGYGFDVTRPAKDAREAVQFLYLAYLAAVKDQDGAAMSLGRTSTFLDIYIEK
                     DICEGKLTEEEAQELIDQFIIKLRIVRFLRTPEYNDLFSGDPVWVTESLGGQGVDGRSL
                     VTKTSYRYLHTLYNLGPAPEPNLTVLWFNNAPDNWKNFCAKVSIDTSAIQYENDDLMRP
                     DYGDDYGIACCVSPMKIGKQMQYFGARANLAKCLLYAINGGRDEKSGVQVAPRFEPITS
                     EYLDYNEVMEKYEQMMRWLAKVYVNALKIIHYMHDKYAYEAFEMGLHDGDVERIRATGI
                     AGLSIVADSLAAIRDTKVKVIRDERGLAVDFEREGEYVPFGNNDDRTDSIAVDITEKFM
                     EYLRQHQTYRKATPTQSILTITSNVVYGKKTGTTPDGRPGGTPFAPGANPMNGRDTKGA
                     VAALASVAKLPFQHAHDGISYTFAVSPATLGKERDIQINNLVSLLDGYFTPDGGQHLNV
                     NVFDRDLLLDAMEHPEKYPQLTIRVSGYAVNFVKLTREQQLDVISRTINSSL"
     CDS             complement(6698..9427)
                     /locus_tag="ctg1_7"
                     /transl_table=11
                     /translation="MNKRFSTLLAAALVAGSFSSAFAQLEGRNVEWKDAQASRAYYLAG
                     VHFVSLTDYLQAFSLQGLVNGADITAANPVAAAQWTVETKKVGTVTHYAFKNIEGEQYL
                     AFEKKDGAYALAAKKEANDETKSFRWFTVAANGNLQAVLSDEKEPYFLGLKNDGTADWS
                     LALLQSSEHHTDGSTSVIKKKVALYEIYNDQITAEAFASKFGENFTIEFPETLDDMDVF
                     ENVSVEKIANDNLGFKLVDNKGTKDTKDDEYVVLANERVSNSELAANAIGYRYAKMTAK
                     AIKDKKIDDKNTVFYAEENETNIGDGKYALVQKVKVGDLDNKDVTFGKVTNDETTRQLA
                     SVEYDCHSTFMGVTVGKGTRVANTEVANERMLIVNVTAKVADKKNSSALGLKNDFTGAR
                     WYDKVSEADFDQPQGQWLVAAGSAANTIKLINVQKPGFVQDNIRLYEAEGENTYTVFAS
                     DLGLSGLETITLTKVEDYDKLNGYYSTLSDINQKFAFVTTGEYANEEAGSDLYLKAGVE
                     GDVVTVVPHAGSEWELIRNEKAQAVTANYKYYDGEKWVELNGKGNEEKGILPADTVRLA
                     YSYAINADELGLGTAWKMAKDDIEFFLKENGKGTYAIVYGATADEVKEYGVINGSEELV
                     AETTDFTNSTPFEIIDLDAAPSLAADSKHMTFEATNSIGFIASDENNNAVLAKETAALW
                     VDSVNAEGYATPKFFISYAGKMMTTAKKFEEIVDKAYANDEISKKEYAELTADENLCYK
                     SVERIKFVDAERLSGEDTLVIADEKYTGKDIEDFKFKVTENEDGDYVLKANGNYVYVIN
                     GNLVYGTDAKEAEAFVIEVTSAPTANEGIATSEVKVIAGEGNVTIAGAAGKKVVISNIL
                     GQVVANTVVSSDNATIAAPAGVVVVAVEGEAAVKAIVK"
     CDS             complement(10066..10461)
                     /locus_tag="ctg1_8"
                     /transl_table=11
                     /translation="VKRGFFFMFPFPISFCPESVRRRVLDLFPQGYVCYFGCAKTITSA
                     WHNRFLGMKRSLHRHETLVGLFLLVFRADDVPQFHLVADLLFCDPSQASGDFGAVLFHT
                     EQIGGGDVRSIDFLYIILMYYSCLIRL"
     CDS             10978..12318
                     /locus_tag="ctg1_9"
                     /transl_table=11
                     /translation="MKRLTNLLAITLLTSCVTAFAQEQEETTTEKSAVEQSADIYAAGY
                     NKFRFGGYGEILANFMDYGINRFRGTDNGSKKDHRNSISIPRFVLAFDYKFNSQWVLGA
                     EIEFEAGGTGSAYEIENTENGEYEMEVEKGGEVALEQFHITRLIHPAFNVRAGHLIVPV
                     GLTNEHHEPINFFGTSRPEGETTILPSTWHENGIEVFGTFGRGYTRFNYQALVVAGLNA
                     NGFDRNTWVAGGKQGLFETDNFTSPGYVARLNYLGVPGLKIGGSFYYCHNTGANSDKPE
                     TYVKYGNIPLRIYTADLQYKNKYVTARANMIYGNLSKADDLSSVNNHQSGGSPYTQTTP
                     IAKRAVSYGGEVGFNLRAVCKDNMSVPVIYPFVRYEYYNPQEKGEGKHTMDLRNKVSMW
                     TAGANWYALPNLVVKADYTTRKIGGGKYNSENEFSLAIAYIGWFLSK"
     CDS             12355..13620
                     /locus_tag="ctg1_10"
                     /transl_table=11
                     /translation="MKKKNYFYLAALSLAMTFSMGACSDNNDPNPDGGGKDPVNLDYSS
                     ENASAWGNYMYNVAMLLNDDATMLYNSWVTDYVDEQGSHGPYATIFKDQTAGAYQSPLS
                     CIEEMIESGMWNIANEVGDAKIKDPYTKYTSGDKEGGLYAVESWYSWHSRDDYTNNIFS
                     IRNTYYGRIDDNDVSKVDGNLSAFNSYKDFDDEGDIAEHSLSKLIASTNPALDEEIKTL
                     IFASAKAIQAIPQPFRNNIDSEESVAAMNTCMELANLLLNEVKPYVNQTFGDPEYDDDL
                     DAIAEQFVDAVVLPTYKDLQEKNKLLLDAVNQFRQNPSNDNFEKACNLWITAREPWEKS
                     EAFLIGPVANLGLDPNMDSWPLDQNGIVQVLNSQNWDDLEWSGNFDEEDEAIGAAQSVR
                     GYHTLEYLLFKDGQPRTVDGAK"
     CDS             13656..13760
                     /locus_tag="ctg1_11"
                     /transl_table=11
                     /translation="MTNLETADKCPLFQGFRVITQCDSRYSEINSENQ"
     CDS             13767..15200
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MKQSYLLTSSLFLLFACAACEEDDKMDMDKIDVPNGYALSAGTST
                     IFLNSSVAYDTNADWITGANSIRFNNGDGLYDDVRTSNNGDGGGLGPVYAGYSCGSCHR
                     NAGRTKPTLWENGGSGNYGFSSMLVYISRRNGAFFRDYGRVLHDQAIYSVKPEGKLSVT
                     YDKQTFSFPDGETYELCKPNYTITEWYKDSIAPEDLFCTVRIPLRHVGMGQMMAIDRRE
                     IEALAAKSNYPEYGISGRCNYITEKGVTGVGLSGNKAQHLDLTVELGFSSDMGVTNSRY
                     PEEICEGQAQINQGSMMGLSYDQLDISTADMEDVDLYMQSLGVPARRNINDPQVILGEQ
                     KFYEAKCHLCHVTTLHTQAGGSTLLNGTRLPWLGGQTIHPYSDFLLHDMGSEIMGVGLN
                     DNYVSGLARGNEWRTTPLWGIGLQEKVNGHTYFLHDGRARNLTEAIMWHGGEGEASKNL
                     FKQMSKEEREAVIAFLNSL"
ORIGIN
        1 gttcggcacg gtacttttgt tgccggacac ccccatgttg ccccctctta cacccggatg
       61 taccggctct ctacacccgg atgttaagga tggcaacatg ggggtgttta cgaaattatg
      121 tgcttgtctt tgctaaaaaa agagagggct tttgtggaat gaagaaccgt atttcgccaa
      181 tttaacacct attgcattcg tttttacatt tgtttattcg attattttat atgctttttc
      241 aaaagcaaat gaaggcaata cattgatttc caatcatatg ataaaaacgt cctgtttcag
      301 gagtgataga ggcagtgata caggatgttt tcctctatca ctcctctaac gcttgaatat
      361 taatagctac aaccttcgta gtgatagagt gatagaggat ttgtagaaaa cttcgtatgg
      421 agatcacaac cttggaaaat tttgatgcgg ttgccctgtt gtgaaagtcg gggctttgtg
      481 tgtaaaaaaa gaaaaggtgt gcaattttga acatacattc atgcagttca atattgcaca
      541 ccttcgtcgt tcatagcaaa tactaaatat taaccgattg aacctctcat gcggtcttca
      601 aaagcagata gagccgcttt tgccccttct cccattgcta tgattatctg tttatagggt
      661 acggtcgaga cgtcgcccgc cgcatagatg ccgggaacat tcgtccgaca atacgcatcg
      721 attacaatct cacccggttt gttcgtttcg acaacgtcgc ggaaaacgcc actattggct
      781 gccaagccga tttggacaaa gattccgtcc aggtcgatca cccgctccgc atccgtctta
      841 cgatctttta cacgaagacc tgtcacctta tcgccattac cgagcacttc caaagattgg
      901 gaatgcaaga aaacttccac attcggcaag ctctttgctt tttcctgcaa cacttggtcg
      961 gctttcagtt cgtccataaa ttccagaacc gtcactttcg aacaaatgcc agccaaatct
     1021 atagctgctt cgatacccga atttccaccg ccgacaaccg ctacgtgctt acctttatag
     1081 aacggaccat cgcagtgagg gcaaaaagcg acaccttttc cgatatagtc cgcttcgccc
     1141 ggaacattca acttgcgcca gcttgcacct gtcgccacga taagggcagg agcagaaaaa
     1201 cgttcaccgg tagaagtggt cagaagtttc gccgatccat ccagttcgac tttatccaca
     1261 cggcgatgct ccagtatatc gaccggatag tcgttgatgt gcatcagaag gtcgttcgcc
     1321 aactgctttc cagtagtctg aggaacggaa atcaggttct cgataccgac cgtttctttg
     1381 acctgtcctc cgatacgttc ggctatcaca gcaacattca agcctttacg tgccgagtag
     1441 atagcagaag ctgcaccggc aggtccaccc cccactatta acacatcata gttcttaaca
     1501 ggtttttcaa cagagttatc aacaccccct tcattaattc cgtattgggc ttcgagtttg
     1561 gaaagcaatt ctcccaaatc actacgcccc acattgatca gtttgccatc ggcaaaaaca
     1621 gaagggactc cctgtacttt cattgcctca acttcttttt ggttgatagc gccatccacc
     1681 gtttcgtggg tgatccggct attgagagta gccatgacat tgagtgcctg cactacatcc
     1741 ggacaattgg tgcaagtaag agaaacataa gtcgtcagct tgatcggacc attcaaggct
     1801 ctgacacgag cacagatact ttcgtccggt atatttttac cttttccatc actattcagg
     1861 acagctaaca acaaggatgt aaactcatgt ccgttaggta ctgcacgaaa ccggataccg
     1921 gtaggcatac cgtcttttac aattgtaaac tgaagtcctt cgccatccgc aacgctgcat
     1981 gacaaatgat ccgagcatga tgccacatca ccaagcaggt ctattagctc ctgacggctt
     2041 tcgtgatcgg gagcgacttg tatatcaaat acatattgag ataccagtcc ggagaaaata
     2101 tccgaaagct ggtctttcat tgctgagtct aacataactt tagatcttac caaccaagtc
     2161 gatgctcggc ttcaaggttg cttcgccttt tttccacttt gcaggacaaa cttcgttcgg
     2221 gtgagaagca acgaactggg cagcttcgac tttacgaagc aattcgtctg cattacggcc
     2281 gataccgtta tcgtggattt cggcaatctt gatctttccc tcgggattta ccaggaacgt
     2341 accgcgataa gccatcccct cttcttcaat catcacaccg aacgcacggc ttaaagcccc
     2401 tgtcgggtct gccagcatcg gatatttgat cttacggatc gtttcggaag catcatgcca
     2461 tgctttgtgt acaaagtgcg agtctgtact tacggaatat acttcgacac ccatttcctg
     2521 aaatttgccg tacttgtcag ccatatcgac caattcggtc ggacatacga acgtaaagtc
     2581 ggcaggatag aagaaaaaga tagcccattt gcccttgata tcttcgctac ttactgtctt
     2641 gaaactacca ttctgaaaag cctgtacttt gaattcgggt acttgtgaat tgataattgg
     2701 ttccatgatt tttactattt aatttgttac tactattttt tgtttaccct acaaaggtaa
     2761 atcgtaagat actgattgaa agaatttttc aaattgataa tttttatctg ccgatagacg
     2821 gatttctatc tgcaagcata cttatctact atgacaatag gaagcaaagt aatgttttcc
     2881 gaaacaataa aaatatacct aattgtaggt aaaatacctt tcgatcatac catgtgattc
     2941 tttaattgtt aactttggat gttaacttaa aaatattcga agatgagaag agctagtttg
     3001 tataatacat tttcagcaag tctattgctc gtttgcaacg catggctttc ttcatgtgtc
     3061 tcacaaatac cccttacaaa ggaaaaaccg gtaaacaatt ccacttatca agtcgaatat
     3121 ctgttcgaac acgaagggtg taaggtctat cgtttcatgg atatgggaca ttacatctat
     3181 ttcaccaact gcgagggaga tgttaccagt attgaaagcg acagcgtccg cacagtcaac
     3241 cggatcagcc gtaaaccgat catcatcaaa gagcagacac tcgattaggc ttatacggtt
     3301 atcccgtgtt tactaaagat cgctttagca ttggccagac gttctgctga aagcggttcc
     3361 acacctttca gcttatagtc caggccttgt gcctcatatt tgtaagctcc cattgtatga
     3421 taaggcagaa gttcggcttt ctggaccacg ttatatgaac tgatatattc ggccagcttg
     3481 ctcaaggctt catcatcgtc cgtcaggccg ggcacgatca cgtggcgaat ccatacaggg
     3541 atgccgcgtt tctccagttc atcaagaaag cgtaaagtat tatcgagttt tacggccgtc
     3601 aaacggggat gaagaccggc gtcgatcgtc ttgatatcta acagaaccag atcgacctgt
     3661 tcgagcacct ccaatgcttt accggaacag atatagccgg aagtgtccaa cgccgtatga
     3721 ataccgttct cacggcaaag gcggaaaaac tctttaagga attcaggttg taacaaaggc
     3781 tcgccaccgg tcacggtaac accaccttta gcgataaaat tcttatagcg cagcacttcg
     3841 gcaagcaacg cttcaggttc cagcagataa ggcgtttcac gctttacctc ccaggtatcc
     3901 ggattgtggc aatacagaca acgaagcgga catccctgca taaaaacgac aaagcgaatt
     3961 ccgggaccgt caacggtccc gaaactctct aaagaatgta tacgccccaa catattaatc
     4021 aatggacaat tataaactgc tgttgatggt gcgcgagatg acgtcaagct gctgttcgcg
     4081 tgtcagcttc acgaagttga cggcatagcc agaaacgcgg atcgtaagct gcgggtattt
     4141 ctccggatgc tccatcgcat ctaacaacaa gtccctatcg aacacgttca cattcagatg
     4201 ctggccaccg tcaggcgtaa aatagccatc caacaggctc accaaattat ttatctgaat
     4261 atcgcgctcc ttacccaacg tagccggtga aacggcaaat gtataggaaa taccgtcatg
     4321 cgcatgctga aaaggcagtt tggctacaga agccaaagcg gcgacagccc ctttcgtatc
     4381 gcgtccgttc atcgggttag ctcccggagc gaacggcgta ccacccggac ggccgtcggg
     4441 agtcgttccg gttttctttc cgtagaccac gtttgatgtg atcgtcagga tagattgtgt
     4501 cggagttgcc ttgcggtatg tctgatgctg gcgcagatat tccataaact tctcagtaat
     4561 gtcgacagca atactgtccg tgcggtcgtc attgtttccg aaaggtacat attcgccttc
     4621 gcgttcgaag tcgacagcca aaccacgttc gtcacggatc actttcactt tcgtatcacg
     4681 gatggcagcc agcgagtcgg caacgataga aaggccggcg ataccggttg cgcggatacg
     4741 ttccacatct ccgtcatgaa gccccatctc gaatgcttca tacgcatatt tgtcgtgcat
     4801 gtagtgaatg atcttcagtg cattgacata gacttttgcc aaccagcgca tcatctgctc
     4861 gtatttctcc atcacttcgt tgtaatccag atactcgctg gtgatcggtt cgaaacgggg
     4921 agccacctgc acacccgatt tctcgtcacg tccgccattg atcgcataca acaagcactt
     4981 tgccaggttg gcacgagctc cgaaatactg catctgctta ccgatcttca tcggagacac
     5041 acagcaggcg ataccgtaat catcgccata gtccggacgc atcagatcgt cgttctcgta
     5101 ctggatggca gaggtatcga tcgatacttt tgcgcagaag tttttccagt tatccggagc
     5161 attgttgaac caaagcaccg tcaggttggg ttcgggtgcc gggccgaggt tatacaaggt
     5221 atgcagataa cggtaagatg tctttgtcac cagcgaacgg ccgtcaacac cttgtccgcc
     5281 cagcgattca gtcacccaaa cagggtcgcc ggagaacagg tcgttgtatt ccggagtacg
     5341 caggaaacgg acaatacgca gtttgataat aaactggtcg atcaattcct gtgcctcttc
     5401 ttccgtcagc ttgccttcgc aaatatcttt ttcgatatag atatcgagga aagtagaagt
     5461 acgtccgaga gacatggctg ctccatcctg atcctttacg gctgccaggt aagccagata
     5521 caagaactgc acggcttcgc gggcatcctt tgccggacgt gtcacatcga aaccataacc
     5581 ggcacacatt ttctcaaatg ctttcagcgc tttgatctgc tccgttatct cctcacggct
     5641 ctgaatgatt tcttctgtca gttcctgtat atcgagacgt ttctggaaac gtttcttttc
     5701 ttcgatcagg atctgagttc cgtacagagg tacacgacgg taatcaccga tgatacgtcc
     5761 gcgtccgtag gcatcaggca acccggtaat gatggcggaa cgacgtgccg caatcatctc
     5821 gtctgtatag gctgaaaaaa cgccttcgtt gtgcgtcttt ctgtatttgg tgaagatttc
     5881 ttttgtcatc gggtccagat gataaccata ggcttccaga ctgttttcga ccatgcggat
     5941 accgcctttc gggaagatac cgcgtttcaa cggggcatct gtctgcaagc cgacgattac
     6001 ttcgttttcc ttatcgatgt aaccgggtcc gtatgtgtca atcccctggg gaagcttcgt
     6061 ttcggcatca tatactcctt tctccctttc aaccttaaac atctcggtta gtttgttcca
     6121 cactttcttc gttttctccg aagagggtac gaggaacgta tcgtctccgt tataaggttt
     6181 gtaattgttc tggataaagt ctcttacatt gatctccttt ttccaggttt ctcctttgaa
     6241 ctgcgcccag ttctcgtttt caaacttcat aagcttatct tgtctatttc ggtttaggca
     6301 cgcaaagata cgtcttttcc ccctatctga aaaggattgt aaaggacgag ggatgttaaa
     6361 ccggagaaaa tacctacaaa tagggataag gggaataaaa acgaagcccc ggcagtacga
     6421 ataccgccgg ggcctgtttt ttgtctgcca tccggtcttc acagagggaa aagcagtaga
     6481 acttttaatt tcattacttt agtattatta atattaaata caaccgcttg ttcgcctgtc
     6541 gcagggtaat tgaaaccata gatcaagaaa acctcttaca tacggtttca cgcaggttgt
     6601 ctagaattat ttgattataa aatgtcattg tgcctgtgta agggtggttc gctaaccacc
     6661 cttacgatag acagtattgt ttttttagta tcaatcgtta cttaacgata gctttaacag
     6721 cagcttcgcc ttcaacagct acaactacta cacctgccgg agcagcgata gttgcgttgt
     6781 cagaagaaac gacagtgtta gctactacct gacctaagat gttgctgata acaactttct
     6841 taccggcagc gcctgcgatt gttacgttac cttcgccagc gatcactttc acttcagatg
     6901 ttgcgatgcc ttcgttggct gtaggagcag aagttacttc gattacaaat gcttcagctt
     6961 ccttagcatc tgtaccgtaa accaagttac cgttgattac atatacatag ttaccattag
     7021 ctttcagtac atagtcaccg tcttcgtttt cagtaacttt gaacttgaag tcttcgatat
     7081 ccttgccagt atacttttca tcggcgataa ccaaagtgtc ttcaccagac agacgttcag
     7141 cgtctacaaa tttgatacgt tctacactct tgtagcaaag attttcatca gcagtaagtt
     7201 ctgcatattc tttcttgctg atttcatcat tagcataagc cttatcaaca atttcttcaa
     7261 acttcttagc agttgtcatc atcttgccag cgtaagaaat gaagaacttc ggagttgcat
     7321 aaccttcagc atttacagag tcaacccaca aagcagctgt ttctttagcc aatactgcgt
     7381 tgttattttc gtcagaagcg atgaagccaa tgctattagt agcttcgaat gtcatgtgct
     7441 tgctgtcagc agccaaagaa ggagcagcat ccaagtctat gatttcgaac ggagtagagt
     7501 tagtaaagtc agttgtttct gctactaatt cctcagaacc attgattaca ccgtattctt
     7561 ttacttcatc agcagtagcg ccatatacga tagcgtatgt acctttacca ttttctttca
     7621 agaagaactc gatgtcatcc ttagccatct tccaagctgt tcccaaacct aattcatcag
     7681 cattgattgc atatgaataa gccagacgaa ctgtatcagc cggcaggata cctttttctt
     7741 cattaccttt gccattcagt tcaacccatt tttcaccgtc ataatatttg tagttggcag
     7801 taacagcctg tgctttttcg ttacggatca attcccattc agaaccagca tgaggaacaa
     7861 cagttacaac atctccttct acaccagctt tcaaatacag atctgaaccg gcttcttcgt
     7921 tagcatattc acctgttgtt acaaaggcga acttctgatt gatgtcagac aatgtactgt
     7981 agtagccgtt cagcttgtca taatcttcaa ctttcgtcaa agtgattgtt tcaagaccag
     8041 acaaacctaa atcagaagca aatactgtgt aagtattttc accttctgct tcatatagac
     8101 ggatattgtc ttgtacaaaa cccggtttct gaacattgat caacttaatt gtgttagcag
     8161 ctgaacccgc agcaaccaac cactgcccct gtggctgatc gaagtcagct tcagaaactt
     8221 tatcatacca acgtgcgcca gtgaaatcat tcttcaaccc cagtgcagaa gaattcttct
     8281 tgtctgcaac tttggcagtt acatttacga tcaacattct ttcgttggca acttcagtat
     8341 tagcgacacg tgtacccttg cctactgtaa cccccatgaa agtagaatgg cagtcatatt
     8401 cgacagaagc caactgacga gttgtttcat catttgtcac tttaccgaaa gtcacatctt
     8461 tgttgtccag gtcaccaact tttactttct gaactaatgc atatttacca tctccgatgt
     8521 ttgtttcgtt ctcttcagca tagaatacag tgttcttgtc gtcaattttc ttgtctttaa
     8581 tcgctttagc agtcattttt gcatagcgat aaccgattgc gttggcagcc aactctgagt
     8641 tggaaacacg ttcgtttgct aaaactacat attcatcgtc ttttgtatct tttgtgcctt
     8701 tgttgtcaac caacttgaaa cccaaattat cattggcgat tttttctacg cttacatttt
     8761 caaacacatc catgtcatcc aatgtttccg ggaactcgat tgtgaagttt tcgccaaact
     8821 tgctcgcaaa agcttctgct gtaatttggt cgttgtagat ttcgtagaga gctaccttct
     8881 tcttgataac ggaagtagat ccatccgtat gatgctcaga actttgtaat aaagccaatg
     8941 accaatctgc tgtgccatcg ttcttcagtc ctaaaaaata cggttctttt tcatcagaaa
     9001 gcacagcttg caaattgccg tttgctgcaa cagtaaacca acgaaacgac tttgtttcat
     9061 cgtttgcctc ttttttggca gctaaagcat aagctccatc tttcttttca aaagccaaat
     9121 actgttctcc ttcaatattt ttgaaagcat aatgtgtaac agttccaacc tttttagttt
     9181 caacagtcca ttgtgcagca gcaacaggat ttgcagccgt aatatcagca ccattcacta
     9241 atccttgcaa agaaaaagcc tgcaagtaat ctgtcagact cacaaaatgc acccctgcca
     9301 aataataagc gcggcttgct tgtgcatcct tccattcaac attacgcccc tccaactgtg
     9361 cgaaagctga actaaaagaa ccggctacca aagcggcagc caaaagagta gaaaatctct
     9421 tgttcataat ctaaaatgtt taattaataa taatatgtat attgaatatc gttcttactt
     9481 cctgtttaac aggtttttac caaattcctg tattttgacg agagaaaacg tacgtttttt
     9541 ttagtcattt ttgaggggct ttctggaggg tttgtgttgg aaagctggtt tttcgtactt
     9601 gttaagctat ctgattgata agaaagaata tagaaaagga aaaataattg gaagaaagga
     9661 ttgcaggttc aaaaagtagt tgtatttttg tgcagtgaaa atggcgaaag aaaacgtacg
     9721 ttttttcgct atttttcttc ttatacccat atacttctta ttagcaatga cttacattga
     9781 aaaaagtgcc taaagccata taaaaaaaga gctgttttca accgctcgcc aaactttttt
     9841 acatcttcat caaaacaaag ataatcaatc acctataaga ttaactccct ttattcacat
     9901 tggaggggaa aaacggcaaa aacagcaggt ttcgtaattt catcttggaa aagctccccc
     9961 ttctgttaaa gatatacaaa atacggagta ttggttgctt agctcaataa cagcttcaag
    10021 acttgcaaaa ccttacatta ttatgtatct ttacatcaac gtccgttaca gacggatcaa
    10081 acaactataa tacattaata taatatataa aaaatcgatg cttctgacat ccccgcctcc
    10141 tatctgttct gtatgaaaca agacagctcc aaagtcacca cttgcttgag aaggatcgca
    10201 gaacaacaga tcggcgacga ggtgaaactg tggcacgtca tcagccctaa ataccaagag
    10261 aaacaaaccg accagtgttt catgcctatg taacgaccgt ttcatgccga ggaaacggtt
    10321 gtgccaagcc gatgtaattg ttttggcaca gccgaagtag caaacatacc cttgcgggaa
    10381 caagtccaag actcgacgcc gaacagattc cggacagaag ctaatgggaa acggaaacat
    10441 aaaaaagaag cctctcttca cagagaggct tcttttttat atcgaaaata accaataaaa
    10501 actttccgat atagttaatc atcttatatg cttacataaa tagcaaaagg ttttgatata
    10561 gcgattatac taatagtgtt actttcttaa tgacattgca aagatacggg tacctccggc
    10621 ctcctacaat acctatatgt gagtaaaaaa acgcctcttg ctacctaatc agggtgatat
    10681 tgaaacaaaa agaaccgttt ttctcaaaac agttcttctt ttgtcgcaag gaaaaccaat
    10741 aaaaatcccc gctgttgtta tttactttaa aataaacatt acattgacat tctatcaata
    10801 aggttccggt cgacgattat acctaatcat gatacataat tgacaaaggc aaagatatga
    10861 gtggacaatc attaacacaa tacctacaaa taggtaacat cgacaccttt ttacctacta
    10921 attgcgattg cacaccgttg acagcccctt taattttgcc aaaaattaaa aaacgcaatg
    10981 aaaaggttaa ctaatttatt agcaatcact ctactaacct cttgtgtaac ggcatttgca
    11041 caggaacaag aagaaacaac gacagaaaaa tccgcagtgg aacaatccgc agacatttat
    11101 gcagccggat ataacaagtt ccgcttcggc ggatatgggg agatcctcgc aaactttatg
    11161 gactacggca tcaatcgttt ccggggtacg gacaacggaa gcaagaaaga ccatcgcaat
    11221 tcgatctcca taccccgttt tgtcttggct ttcgattaca aattcaattc ccaatgggta
    11281 ttaggagcag aaatagaatt tgaggctgga ggtacgggaa gtgcctatga gatagaaaac
    11341 acagaaaacg gagaatacga aatggaagtt gaaaaaggcg gtgaagttgc tttggaacaa
    11401 ttccacatca cacgtcttat ccatccggcc ttcaatgtcc gtgccggtca tttgatcgtc
    11461 ccggtcggtt tgaccaacga gcatcatgag ccgatcaact tcttcggaac ttctcgtccg
    11521 gaaggtgaaa cgaccatcct tccttctacc tggcacgaaa acggtatcga agtattcggt
    11581 acgttcggtc gaggctacac acgtttcaac taccaggctt tggtcgttgc cggattgaac
    11641 gccaacggtt tcgaccgcaa cacatgggtt gccggtggta agcaaggact attcgaaaca
    11701 gataacttca cctcaccggg ctatgtggcc cgcctgaact atttaggagt accgggattg
    11761 aaaataggcg gttccttcta ctattgccac aatacgggag ccaattccga caaaccggaa
    11821 acatacgtca aatatggaaa catacctttg cgcatctata cggctgacct gcaatacaaa
    11881 aacaaatatg tcaccgcacg cgcaaacatg atatacggca acctgagcaa agccgacgac
    11941 ctcagcagtg tcaacaacca ccaaagcggc ggttctcctt atacacagac aaccccgatc
    12001 gccaaacgtg cggtcagcta tggtggcgaa gtggggttca acctgcgtgc ggtttgtaaa
    12061 gacaatatga gcgtacccgt aatctatccg ttcgtccgct acgaatacta caacccacag
    12121 gaaaaaggcg aaggcaagca cacgatggat ttacgcaaca aagtaagcat gtggacagcc
    12181 ggagccaatt ggtatgcttt acctaatctt gtcgtgaaag cagactatac aacacgcaaa
    12241 atcggaggcg gcaaatataa cagcgaaaac gaattcagct tggctatcgc ctatatcggc
    12301 tggttcctca gcaaataaaa acaatataaa caaattaata acttatcaat aaaaatgaaa
    12361 aagaaaaatt atttctatct ggcagcctta tcgctcgcca tgacattctc gatgggagca
    12421 tgtagcgaca acaacgaccc caatccggat ggtggcggaa aagatccggt caacctggat
    12481 tacagttctg aaaacgccag tgcatggggt aactatatgt ataacgttgc aatgttgctg
    12541 aacgacgatg caaccatgct ctacaattct tgggtaaccg actacgtcga tgagcagggt
    12601 tcacacggcc catatgccac gattttcaaa gaccagactg ccggagctta ccaaagcccg
    12661 ctctcgtgta tcgaggaaat gatcgaaagc ggtatgtgga acatcgccaa cgaagtaggt
    12721 gacgccaaga tcaaggaccc gtataccaaa tataccagcg gtgacaagga aggcggtctc
    12781 tatgccgtcg aatcatggta tagctggcat tcgcgcgacg actatacgaa caatatcttc
    12841 tccatccgta acacatacta cggccgcatc gacgacaacg acgtgtccaa agtagacgga
    12901 aacctgagtg cattcaactc ttacaaagat ttcgacgatg aaggagacat cgcagaacac
    12961 tcgctttcaa aactgatcgc ttcaaccaac ccggctctcg acgaagaaat caaaacgctg
    13021 attttcgctt ctgcaaaggc gatccaggct attccgcaac cgttccgcaa caacatcgac
    13081 agcgaagagt ccgttgccgc aatgaacact tgcatggaac tggccaacct gttgttaaat
    13141 gaagtaaaac cgtatgtaaa ccaaacattc ggcgatcctg aatacgacga tgaccttgat
    13201 gcaatagccg aacagtttgt cgatgcggtc gttcttccta cttataaaga cttgcaggaa
    13261 aagaacaagc ttttgctgga tgcggtaaac cagttcagac aaaacccaag caacgacaac
    13321 ttcgaaaagg cctgcaattt atggatcacg gcacgcgaac cgtgggaaaa gagcgaagct
    13381 ttccttatcg gtccggtcgc caacttaggt ctggacccca acatggacag ctggcctttg
    13441 gaccagaacg gtatcgtaca ggtattgaat tcacaaaact gggatgacct ggaatggagc
    13501 ggaaactttg acgaagaaga tgaagccatc ggagccgcac agagcgtacg tggttaccat
    13561 acattggaat atctcctatt caaagacggg cagccccgca ctgtcgatgg agcaaaataa
    13621 acatgcctct gagacataaa acttgataat agatcatgac aaaccttgaa acagcagaca
    13681 aatgcccgct gtttcagggt ttcagagtaa ttacacaatg cgactcgcgt tattcggaaa
    13741 taaattcaga aaaccaataa aatgatatga agcaatctta cctgttaaca tcctcgctat
    13801 tcctgctctt tgcatgcgca gcttgtgaag aggacgataa aatggatatg gataaaatag
    13861 atgtcccgaa cggatatgcg ctgtcagcag ggacttcaac gattttccta aactcatcgg
    13921 tcgcctacga tacgaacgcc gactggataa caggagccaa ctcgatccgt ttcaacaacg
    13981 gcgacggtct ctacgacgat gtacgcacca gcaacaatgg cgacggaggc ggtctcggac
    14041 ctgtttatgc cggctattcc tgcggcagtt gccatcgcaa cgcaggaagg accaaaccga
    14101 cattgtggga aaacggcgga tcgggcaact acggtttctc ttccatgctg gtctatatct
    14161 cccgccgcaa cggtgctttc ttccgcgact acggacgtgt attgcacgac caagccatct
    14221 acagcgtcaa accggaaggt aagttgtccg tcacatacga caagcagact ttttccttcc
    14281 ccgacggaga gacttacgaa ctatgcaaac ccaattacac gataaccgaa tggtataaag
    14341 acagtatcgc cccggaagat ttgttctgca ccgtacgcat cccgttacgc cacgtcggta
    14401 tgggacagat gatggcaatc gaccgcaggg aaatcgaagc gctcgctgcc aaaagcaatt
    14461 atccggaata tggtatcagc ggacgttgca actatatcac cgagaagggt gtcaccggtg
    14521 tcggcctttc aggaaacaag gcacagcatc ttgacctgac cgtcgaactg ggcttttcaa
    14581 gcgatatggg cgtgacaaac agccgctatc cggaagagat ttgcgaaggg caggctcaga
    14641 tcaaccaagg cagcatgatg ggactctcgt acgaccagct cgacatatcg accgccgata
    14701 tggaagatgt ggacctttac atgcaaagcc tcggcgtacc ggcacggcgc aacataaacg
    14761 accctcaggt catcttagga gaacaaaagt tttacgaagc gaaatgccat ctctgccacg
    14821 tcactacgct gcacacgcaa gcgggcggtt ccacactgct caacggcaca cgtttgccat
    14881 ggctcggcgg acagaccata catccttatt ctgatttcct actgcatgac atggggtcgg
    14941 agatcatggg agtcgggttg aacgacaatt atgtcagcgg cctggcacga ggaaacgaat
    15001 ggcgtactac gccgctttgg ggtatcgggc tgcaggagaa agtcaacggt catacctatt
    15061 tccttcatga cggacgcgcc cgcaacctga ccgaagccat catgtggcat ggaggcgaag
    15121 gggaagcctc caaaaattta ttcaaacaaa tgagcaagga agagcgtgag gcagtgatcg
    15181 cattcctcaa ctccttataa tttatccata agacaaacta aaatgaaaca actgataatc
    15241 acaattgcag cattattact attgccgttg gccgtcatgg cccaatatga ggaagatacg
    15301 gaaaacggtg tcgtatcact aaacggcaaa gaaggtttta caatcgctac caagaagggg
    15361 gatttcgttt tcaaacctta tatgttggtc cagaccagtg ctaacatcaa ctactacgac
    15421 gatgaagggc tggacccggc ctacaatcag gacaatatac acaacagcgg tttctcgatc
    15481 ccttatgcca tcctcggttt cacgggcaag gcattcgacc gggtgacatt caacctctcc
    15541 atcaatgctg ccggaaacgg aggaaacatc cttcaacagg cttggttcga cgtagagata
    15601 aaaaagagtt ttgccatacg tgttggcaag ttcaagactc cgttctcgca cgcttacctg
    15661 actacgctgg gcgagacgtt aatgccgaca ctgccgacat cgctcacctc atccgttatc
    15721 ctgccttatt ctcttaatgc cgtgacaccg aacatcggca tgggattcga cctcggagtg
    15781 gaagtgcacg gattggtaaa ggataagttc ggctacgaag ttgggatttt caacggaacg
    15841 ggaagctccg tcaacgtggc atccaaaacg ttcagcgacg actggcatat cccgtcattg
    15901 ttgtatgccg gccgcatcac gtacatgccg aaaggagtta tgccgtccaa ccagggcagc
    15961 ccgaaccgtt tgaaggaaga taagatgctg ttcggtcttt ccacttcatt gaatgtggag
    16021 agcgaaagcg aaagtacgaa cgatttccgg gcaggagcag aattcgccat gttgaagaat
    16081 cgcctgtatc tcggcgctga aatctattat atgaatgtag ggtttaccaa acggcagaaa
    16141 attgacgaga gctataacta tttagggggg tacgtgcaag gcggttattt cgttaccaac
    16201 aaactacaag cgacagcccg ttatgacttc ttcaaccgca acggattgga cacaaacggt
    16261 tttctgaata
//
