LOCUS       c00009_gnlPro..        16278 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CFLJKNLG_53.
ACCESSION   c00009_gnlPro..
VERSION     c00009_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 06:50:22
            Original ID  :: gnl|Prokka|CFLJKNLG_53
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16278
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16278
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2726:6278](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2727..6278
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16278
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16278
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(154..1353)
                     /locus_tag="ctg9_1"
                     /transl_table=11
                     /translation="MTKKALYIFNPEHDLALASGETNYMAPASARQMASELALLPMWYA
                     EEGSVVLAPSAYNLDYVKKIQELLGLSVDLMTEPELASERNLDIRPWGWDIAIRKRLLD
                     LGVEESELPSIEQLDKLRFCSHRSCAVGLLPQLQLGACFCGESFYLTFPEEWKSFVESH
                     DTCLLKAPLSGSGKGLNWCKGVYTPSISGWCSRIGNQQGGVIGEPLYNKVEDFAMEFRS
                     SGNGRFGFAGYSQFRTGGSGAYEGNLLISDAAIERNLLEYIPVEEIYKLRDRLEQELSL
                     RFGTIYNGYLGVDMMICRFPESPVYRIHPCVEINLRMNMGVVARHIYDHYIYPTSTGAF
                     QISYYPTEGTAWRAHKEMEEAYPLEIEQGRIKSGYLSLVPAHKKSSYRAWVFISKSVFL
                     "
     CDS             1516..2694
                     /locus_tag="ctg9_2"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     RELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREYLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFANSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             2727..6278
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_3"
                     /sec_met_domain="PFOR_II (E-value: 4.9e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 5.6e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 5.6e-31, bitscore: 100.4,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-11, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 2e-11, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 3.1e-08, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00015, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 9.6e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMNPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKTKQHLVDIKSNVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARIVKLFNEILAADNASPEAKEVLKAWIENMYDADKTKE
                     LAPQVKAVIEEGLSHGCPICKELKGLTQYLVKRSQWIIGGDGASYDIGYGGLDHVIASG
                     KDVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQI
                     AMGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLW
                     RYNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAK
                     WRYNSYKRLARENWGAE"
     CDS             complement(6239..6388)
                     /locus_tag="ctg9_4"
                     /transl_table=11
                     /translation="MNSSGKKVVLFMLDRVHTIKNGNLLQDYRFLFIGYYYYSAPQFSL
                     AKRL"
     CDS             complement(6430..7302)
                     /locus_tag="ctg9_5"
                     /transl_table=11
                     /translation="MHVRIYKIVGIVLSAMLLLASCTNSDLEKKKVKIAYANWLEGIAM
                     SHLAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEF
                     LGEVYGEARVGLVVPQYVTIQSINELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGL
                     DGYTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEI
                     HAIAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRLLVD
                     SWIPKSENK"
     CDS             complement(7320..8144)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.5; E-value: 8.7e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg9_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.2e-28, bitscore:
                     92.5, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMVHFSTFFDAVNAGIGSFIIGFQHILFGIP
                     FYITILVLATLAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSPRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(8141..9367)
                     /locus_tag="ctg9_7"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTAGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGD
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSKQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETREFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(9666..10004)
                     /locus_tag="ctg9_8"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMSQ
                     CSRMVGRALKQIPDDLSAPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             10088..11383
                     /locus_tag="ctg9_9"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPNKSNPIINKTSTAVMKKKTILFASCLLGA
                     LAFSSCEKNLYDESKQPEKEKRITDLNIPADFDWKGSQNAKVKIASQSTATISVFLEEN
                     CNEEALMLRMDVDANISKLELPIEIPAYIKNVYVKYGNGSEIQTVPVESNGTISIVVPA
                     NATALSRVTTRANKEVETNNIFNYPGYGNGTIMFEDMYPALGDYDFNDFVAWYNFQIDG
                     FYWSHNQCYAEYLMIGFQIRAIGGIYDYNPYIRLAEVQYNELDLEETQMYLERNNPEEA
                     ENIKILKGPKGELIISLKKPAIPNGYKYYNTEVNEKTKPKKMMAIYLVFNSPVNVKSLQ
                     DSKMDFYIAKTNKGQEIHLKGYSPVYYNSNESYVNEDNFIWGLKVPASLHHAREEVNFL
                     EAYPDFEQWVTSGGQKNQRWWNKPKTNKLIMN"
     CDS             complement(11525..14407)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 62; E-value: 2.1e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_10"
                     /sec_met_domain="Peripla_BP_1 (E-value: 2.9e-19, bitscore:
                     62.0, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEAMKYTKWITVLLCLLGLAACRQDAPRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDKGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNYPDIKLIDKADAAWEREPAEVEMDSMLHRHPKIDAVYAHNDRI
                     APGAYQAAKKAGREKEMIFVGIDALPGKGNGLELVLDNVLDATFIYPTNGDKVMQLAMN
                     ILEKKSYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRSKNRLNKELSEQKKQVEQQRDKLEEQRDILEEQRD
                     KLEEQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADSSLSEDQR
                     RMLLLVQRNVNILLRLVNQILDFRKYENGKMEYTPISLDILSSFEGWNESFMAAARKKH
                     IHFSFDYMPDTDYRTLADVEKLERIYFNLLSNAFKFTPENGKVTVRLSSLTKDDHCWIR
                     FTVANTGSMISAEHIRNIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTITVESDEKQG
                     TIFTVDLPVQTCETVVSENSPAFSVPATSVTSTDAATSAVAGAPVTPATSGYSGSSSLN
                     DALTYEEEELEKSYDSSKPCVLIIDDNADIRLYVHGLLHTDYTVIEAADGSEGIRKAMK
                     YVPDLIISDVMMPGMDGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYI
                     SKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGD
                     SNLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGY
                     EVGFSSPSYFTKCYREQFGESPTDLLKRKG"
ORIGIN
        1 cgaagttgtc aactaaatcc agtacagtac atcacatggc atgtgattac ttgtttcatg
       61 caatgaaact ttttgtttct cggtgtggaa ccaatggttt cactgcatga aactatcagt
      121 ttcacaccga gaaaccataa cttcgatata atatcacaaa aacacgcttt ttgagataaa
      181 cacccacgcc cgataactac tctttttatg agccggcacc aatgacaaat agcctgattt
      241 tattcttcct tgttctattt ccaaaggata agcctcctcc atttctttgt gtgctctcca
      301 ggctgttcct tccgtagggt aatagcttat ttgaaaagct cctgttgaag taggatagat
      361 ataatggtca taaatatgac gcgctactac tcccatattc atcctcaagt tgatttccac
      421 gcaaggatga atccgataaa caggagattc tggaaagcga cagatcatca tatccactcc
      481 caaataacca ttataaatgg ttccgaaacg gagggataat tcttgttcaa ggcggtcgcg
      541 caatttataa atttcttcga cagggatata ttccaaaaga ttccgttcga tggctgcatc
      601 tgaaatcagc agattacctt cgtacgcccc acttccaccc gtacggaatt gagagtatcc
      661 ggcaaagcca aatcgaccat tacccgaaga acgaaattcc atagcaaaat cttccacctt
      721 attatataga ggttcgccaa taacacctcc ttgctggttg ccaatgcgtg agcaccaacc
      781 ggaaatggaa ggagtatata cacctttgca ccaattcaac ccttttccgc taccggataa
      841 aggagctttc agtaaacaag tatcatgtga ttctacaaat gacttccatt cttcgggaaa
      901 cgtcaggtaa aaagactctc cacaaaaaca ggctcccagt tgtagctgtg gtaataatcc
      961 cacagcgcag gaacgatggg aacagaaacg cagtttatcc aattgctcaa tagaaggaag
     1021 ctcgctttct tccactccca aatccaacag tcgttttctt attgctatat cccagcccca
     1081 aggacgaata tccaaattcc gctccgaagc aagttcaggt tctgtcatca aatcaaccga
     1141 aagtcctaat aattcctgta tcttcttcac atagtcgaga ttataagcgg aaggagccaa
     1201 tacaacactt ccctcttctg cataccacat cggcaacaaa gccaattcgg atgccatctg
     1261 ccgggcggaa gccggtgcca tatagtttgt ttcaccgctg gctaacgcca aatcatgttc
     1321 cggattgaat atataaagag ccttttttgt cattttaaac gaattcaaaa ctttattctg
     1381 caaatatata caggaaatag tcaggaatgg ctacaataaa cagaaagttc taattaaact
     1441 cacaattttg ccatctctac tttgcaaatc ctaaaaaaag cagtatattt gccacccgaa
     1501 aaacaaagaa ctgaaatgga atcattctat cgcacacacg cctacctcgt tgagcacacc
     1561 aatgcccccg ttcgccgcga tcttatggac gagatcgact ggagcgaccg cctgattggt
     1621 atcaaaggga cacgtggcgt aggaaaaacc actttccttc tccaatacgc caaagaaaaa
     1681 tttgggaacg accgctcctg cctgttcatc aacatgaaca acttctactt ctctggccac
     1741 agcattgtag actttgctaa cgaattccag aaacgtggtg gaaaagtatt gttgatcgac
     1801 caagtgttca aacacccgga atggagcaga gagttgcgca tgtgttacga ccgttttcct
     1861 aatttgaaaa ttgtctttac cggctcatct gtaatgcgac tgaaagagga aaatcttgaa
     1921 ttgcgtgata ttgcaaaaag ctataacctg cgcggatttt ctttccgcga atacctgaac
     1981 ttacaaacag gcatgaaatt cagggcctac agtctcgaag aaattcttag cactcacgaa
     2041 cagattgcca aaggagtact ctctaaagtt cgtccgctgg attacttcca ggattacctg
     2101 catcatgggt tctatccatt cttcctcgag aagcgtaact tttcggagaa tttgctgaaa
     2161 acgatgaaca tgatggtgga agtagatatc ctgctcatca aacaaattga actgaaatat
     2221 ctttcaaaga taaaaaaatt actatatttg ctcgctgtcg acggaccgaa ggctcccaat
     2281 gtgagtcaac tggcaagcga catacagaca tctcgcgcca cggtgatgaa ctatatcaag
     2341 tatctggcag atgcgcgact cattaatctg gtttatccga aaggagaaga atttcctaaa
     2401 aaaccttcca agataatgat gcacaactcc aacctgatgt attccatcta tcccgtgaaa
     2461 gtggaggagc aggatgtact cgacacattc tttgcaaatt ctttatggaa agaccataag
     2521 gtacataaag gagataaaaa cgtctctttt atggtggacg aagtaatgcc gttcaaaatt
     2581 tgccaggaag gagcaaagat caagaacaat ccgaatgtga cgtacgcgtt gcataaggct
     2641 gaaataggtc ggggcaacca gatacctctc tggatgttcg gctttttata ttaaaagatt
     2701 tatttactta aatatttaat ttagttatga ctaaacagaa gaaattcatc acttgtgatg
     2761 gtaaccaggc tgcagcgcat atctcgtata tgttctctga agtagctgct atctacccca
     2821 tcactccttc ttcgactatg gctgagtacg tagacgaatg ggctgccgca ggacgtaaga
     2881 acatcttcgg cgaaacagta ttggtacagg aaatgcaatc tgaaggtggt gctgccggtg
     2941 cagttcacgg ttctcttcag gctggtgcgt tgactactac ttacactgct tctcaggggc
     3001 ttctcctgat gatccctaat atgtacaaaa ttgccggtga gttcttgcct tgcgtattcc
     3061 atgtatctgc tcgtacattg gcttctcacg cattgtgtat cttcggtgac caccaagacg
     3121 taatgtcagc tcgtcagact ggctttgcga tgttggctga aggctctgta caggaagtta
     3181 tggatttggc tggtgttgct cacttggcta ccatcaaatc tcgcgttccg ttcatgaact
     3241 tcttcgatgg tttccgtaca tctcacgaaa tccagaagat tgaaatgttg gaaaatgatg
     3301 atcttgctcc gctgatcgat caggaagctt tggctgaatt ccgtgcccgc gcactgaatc
     3361 cgatgaatcc ggttgctcgt ggtatggctg aaaaccccga ccacttcttc caacatcgtg
     3421 aatcatgtaa caactactat gaagcagttc ctgctatcgt agaagaatac atgaatgaaa
     3481 tttctaagat tacaggtcgt aaatacggtt tgttcgatta ctatggtgca gaagatgcag
     3541 aacgcgtaat tatcgctatg ggttctgtaa cagaagctgc ccgcgaagct atcgaccact
     3601 tggtagcaaa tggcgaaaaa gtgggtatgg ttgccgtaca cctgtatcgt ccgttctctg
     3661 ctaaacactt cctggctgct gtacctaaga ctgccaagac tatcgcagtt cttgaccgta
     3721 ctaaagaacc gggcgctaac ggcgaacctc tttaccttga cgttaaagac tgcttctacg
     3781 gcgcagaaaa tgctccggtt atcgttggcg gtcgctacgg tttgggttca aaagatacta
     3841 ctcctgctca aattctttca gtattcgaaa acttggccat gccaatgccg aagaatcact
     3901 tcactatcgg tatcgtagac gacgttactt tcacttctct tcctcaaaaa gaagaaatcg
     3961 ctttaggcgg tgaaggaatg ttcgaagcta aattctacgg tttgggtgct gacggtacag
     4021 taggtgctaa caagaactct gtaaagatta tcggtgacaa cactgacaaa cactgccagg
     4081 cttacttctc ttatgactct aagaagtcag gtggtttcac ttgttctcac ttgcgtttcg
     4141 gtgatactcc gatccgttcc acttatttgg taaatactcc gaacttcgtt gcttgtcacg
     4201 ttcaggctta cctgcacatg tacgatgtaa ctcgtggttt gcgtaagaac ggttctttct
     4261 tgctgaacac tatctgggaa ggtgaagaac tggctaagaa cctgcctaac aaggttaaga
     4321 aatattttgc acagaacaac atttccgtat actatatcaa cgcaacacag attgcattgg
     4381 aaattggttt gggtaatcgt accaacacta tccttcaatc tgcattcttc cgtatcacag
     4441 gtgttattcc tgtagaccag gctgttgaac agatgaagaa attcatcgtt aagtcttacg
     4501 gtaagaaggg tgaagacgtt gttaacaaga actatgctgc cgttgaccgt ggtggtgaat
     4561 acaagacttt agctgttgat cctgcttggg ctaacctgcc ggatgatgca aaagctgaaa
     4621 acaacgatcc tgcattcatc aacgaagtag ttcgtccgat caatgcacaa gatggtgact
     4681 tgctgcctgt atctgcattc aagggtatcg aagacggtac ttggtatcaa ggtacttcta
     4741 aatacgaaaa acgtggtgta gccgcattcg ttcctgaatg gaatccagaa aactgtatcc
     4801 agtgtaacaa gtgtgcatac gtttgtcctc acgcttctat ccgtccgttc gtactcgatg
     4861 ctgaagagca gaagggtgct aagttcgaac aattgaaagc agtaggtaaa gtattcgacg
     4921 gtatgacatt ccgtatccag gttgacgttc tcgactgtct gggttgcggt aactgtgctg
     4981 acatctgtcc gggtaatccg aagaagggtg gcaaagcatt gacaatgaaa cacctcgaaa
     5041 gccaattggc tgaagctgac aactggactt actgtgctga aaacgtgaag actaaacaac
     5101 atcttgttga tatcaagtct aacgtgaaga actcacagtt cgctactccg ttgtttgagt
     5161 tctctggtgc ttgctctggt tgtggtgaaa ctccgtatgt gaaattgatt tctcaattgt
     5221 tcggtgaccg tgaaatggtt gctaacgcta ccggatgttc ttctatctac tctggttcag
     5281 ttccttctac tccgtatact acgaacgaaa acggtcacgg tcctgcttgg gctaactcac
     5341 tgttcgaaga cttctgtgaa ttcggtttgg gtatggaatt ggctaatgaa aagatgcgtg
     5401 ctcgtatcgt gaagttattc aacgaaatcc ttgctgccga caacgcttca cctgaagcaa
     5461 aagaagtgct gaaagcatgg attgaaaaca tgtacgatgc tgacaagact aaagaattgg
     5521 ctcctcaagt gaaagcagtg attgaagaag gtctttctca cggatgtcct atttgcaaag
     5581 aactgaaagg actgactcaa tatcttgtaa aacgcagcca atggatcatt ggtggtgacg
     5641 gtgcttctta cgatatcggt tatggtggtc ttgaccatgt aatcgcttcc ggtaaggacg
     5701 ttaacatcct cgttctggat actgaagttt actctaacac aggtggtcag tcttctaagg
     5761 ctactccggt aggtgctatc gctaagttcg ctgctgctgg taagcgcgta cgtaagaaag
     5821 acctcggtct gatggctact acttacggtt atgtatatgt tgcacagatc gctatgggtg
     5881 ctgaccaagc tcaaactctg aaagctatcc gtgaagctga agcatatccg ggaccatctt
     5941 tgattatcgc ttacgctcca tgtatcaacc acggtctgaa agcaggtatg ggtaagagcc
     6001 aggaagaaga agaaaaggct gttaagtgcg gttactggca cttgtggcgt tacaacccgg
     6061 ctctggaaga agaaggcaag aatccattcc aattggatag caaagaaccg aactgggaag
     6121 atttccaagg tttcttgaaa ggtgaagttc gttacgcttc tgtaatgaaa caatatcctg
     6181 ctgaagctga agaactattc aaagctgccg aagaaaacgc taaatggcgt tacaacagct
     6241 acaaacgttt ggctagagaa aactggggtg ctgaataata gtaataccct ataaataaaa
     6301 aacggtaatc ttgtagaaga ttaccgtttt ttattgtatg aactctgtcc aacataaaca
     6361 gtactacctt tttcccacta gagttcatgt ctattttata tttaaaatta agaataacaa
     6421 tgctccaatc tatttattct ctgacttcgg aatccaacta tccaccaaca gccgatgctc
     6481 atccctccat ttacgggcta tttcttcttc atccatcctg gcatccttca tagctgtcat
     6541 aaaagagcta agttcttctg tcgttagttt gatgttgcca aagaactcgg cagcaaacgg
     6601 atctttctca ctgaatcctt tccatgcaat agcatgtatt tcttccaagt ctccatatac
     6661 tttcttcgga tcatccaaga atttcaagtc aaactggtcg aacatccaat gcggtgtcca
     6721 ccccgtaatg acaatccatt ctcctttgtc catcgctttt ttcaaagaag ccagcatggt
     6781 ggaactactt gaagtcatga gggtataccc atcaagtccg taagcagcaa tggccttatc
     6841 ggtcgtcttc attatccctg ctcccgcatc aattcctact atttcagaag aaaaacggtc
     6901 tttattagct tccagctcat taatagactg gatcgtaaca tattgaggaa caaccagtcc
     6961 gacgcgagct tctccgtata cctcccccaa aaattcgatg ctgtctccat actgatccat
     7021 ataatctttc atcgttattg gtaaccaggc atccagaaac acatctgatt tctttcctga
     7081 catagataca aaaatagggg caagatcagc attttgcaat tcaacctcat atccatgctc
     7141 ttccaatacc accttagcca aatgactcat ggcaatacct tccagccaat tggcataggc
     7201 tatttttact ttctttttct ctaagtctga attagtacag gaagctagca aaagcatagc
     7261 cgaaagcact attcctacta ttttatatat tctcacatgc atttttattc ctttccgttt
     7321 tagttcttat tttttcgtcc tgccattcct tgtgtgatac ggtctaagat gatagctaaa
     7381 ataacaacag ctataccacc ttcaaaccca agtccgattt tcatttgggt aatacctttc
     7441 aatacaattt ctcccagacc accggcagca atcatggcag caatgacaac catagaaagc
     7501 gacatcataa ttgtctggtt gacacctgtc agaatggtgg gcaacgccaa aggaagctgc
     7561 actttataca ataactgcca acgggtagcc ccgaacgaac gggaagcttc cactacattt
     7621 ttaggaactt gccgaattcc caatccggta aggcggacta caggaggcat agcaaagata
     7681 atggtagcaa acactcccgg cactgctccc aatccgaaaa acaaaacagc aggaatcaga
     7741 taaacaaaag caggcatcgt ctgcatcaag tcgagaacag gacgaagtat tttctctgca
     7801 cgcggactgt ttgccgtcca cactcctaaa ggtacaccaa caatcagagc cagacaggta
     7861 gatgaaaaaa cgagagccag ggtttgcata gtagcctccc agaatcccat tccatagatc
     7921 agtaataatc ccaatgcggt gaaaattgcc gtaccgcgtc ctgctttcat ccatgcgagt
     7981 gtagcaagta ccaaaatggt tatataaaaa ggtattccga aaagtatgtg ttggaatcct
     8041 ataataaaac taccgatgcc cgcattcacg gcatcaaaga aagtggaaaa atgtaccatc
     8101 atccaattga tggccatctc tatatattgt cctatattta tcataaatct attgcgtttt
     8161 gaattatttc gtttatttct tctttgtctt tcccggtcac ttcgatgatt aaggatgaaa
     8221 gcgggattgt tcctaaaaac tcgcgcgtct catcaatcac ccataccggc gaattgctct
     8281 ttgtcattag aggaagtata tcctccaaca ccgtatcctc caacacagaa tgtacttctg
     8341 tacgcacaat cgtttcaatg gatttttcct gtttgctacg taacttaagc aagtcgttca
     8401 gacgtacttc tccgaccagt ttatcatcgg cgtctatgac aggtaatacg gtgatattct
     8461 tcgcacgcat cttacgaatc aatacttcgg gaccttcttt cttcagacgg gccaccaacg
     8521 gtttgtcaat cattaaagaa gaggcggtaa taattttgct cctatccacg ttttcaacaa
     8581 aacgggctac ataatcgtta gccggttcag tcaggatttc ctccgaagta cctacctgca
     8641 ccacttctcc gtctttcatg atggcaatac ggtcacctag cttaattgct tcactcaagt
     8701 cgtgggtaat aaaaacaatc gtctttttca tctttgattg caaggccagt agttcatcct
     8761 gcatctgtac gcgaatcaga ggatcgagag cagagaaagc ctcatccatt aaaagcactt
     8821 caggattatt agccagagca cgagccagtc cgacacgctg ttgcattcca ccggaaagat
     8881 cgcctaccat ctgattttca tatcctttca atccgacaag cttcatgctt tccatcgctt
     8941 tcttctcacg ttcctctttc ttcactccct gaagttcgag gccgaacgcg atattgctca
     9001 atacggaacg gtgaggtaac agaccgaaat tctggaaaac catcgccagc tctttccggc
     9061 gaacctgcaa taattctttt tcggaaattt tagatatatc tactccgttt acaagcactt
     9121 gtccggcagt aggacgtatc agacgattga tacaacgcag taatgtcgat tttccacttc
     9181 ccgagagtcc cattatcacg aaaaactctc cttcattaat tgaaagattg gcatctttca
     9241 ctcctaccgt acaaccggta tctttcagaa tttcctcttt actcttatct tttttcaaca
     9301 tcttgagggc tttctgcttc tcgttaccaa agataaggta caaatccttt atttctattt
     9361 tactcatata atatattggt ttagattata atatttgttt tgttttcaac tgccgcattc
     9421 cttattctca cttacgataa acaagttgaa tgttcgcatg gttcagtcat gccacatgat
     9481 aacatgacgg tccgacgttt tttaaatggt taaaaaaaac agacagagta gtttaaaagg
     9541 aatagaattt gataagatta tcctcttaat gaacagtaga aaatagtatt ttcataaata
     9601 aataacagtc tgttcttgca tattgttggc acaaaggtaa ggaaaataga ttaaatatgc
     9661 aaatttcatt caggtacgga gtaattccaa agatgctttt tcaagtctac gcatccattt
     9721 tgtttgaaag agatcccttc ttccaacaag agttgtttct gctctgtcca acccggaaca
     9781 agccgtcccg acgcattgac aacccgatga caaggcgcag ataaatcatc cggaatctgt
     9841 ttcaaagcac gccccaccat acgggaacat tgagacattc ccaataatgc ggcaattccc
     9901 ccataggtag aaactttacc taccggaatt tctcggacaa cctgatacac ctcttgacaa
     9961 aaggatgcgg aaaggctcgc cttatctact ttataatctt tcatcactca aacattactt
    10021 tatttcagtt ccaaaactag ataaaaagaa aagaatttgc aaataataaa agcatttcaa
    10081 ataaaatatg caactttatt tgctttattt acaaataatc ccgacctttg tccccaataa
    10141 aagcaaccct attattaaca aaacaagcac tgctgttatg aaaaagaaaa ctatcctgtt
    10201 cgcttcttgt ttattgggag cactggcttt cagctcctgt gagaagaacc tttatgatga
    10261 aagtaaacaa cccgagaaag aaaagagaat aacagacttg aatattcctg ctgactttga
    10321 ttggaaaggt tctcaaaatg ccaaagtgaa aattgccagt caatcaactg ctactatttc
    10381 tgtatttcta gaagaaaatt gcaatgaaga ggctttgatg cttcgaatgg atgtcgatgc
    10441 caacatatca aaattggaac tcccaattga aattcctgca tatataaaaa atgtgtatgt
    10501 aaaatatggt aatggctctg aaatacaaac tgttcctgtt gaaagtaatg gtactatttc
    10561 tatagtagta cctgctaacg ctacggcatt atccagagtt accacaagag ctaataaaga
    10621 agttgaaacg aacaacatct tcaattatcc gggatatggc aacggaacta ttatgttcga
    10681 agatatgtat ccagctttag gcgattatga ttttaatgat tttgttgcat ggtataattt
    10741 ccaaattgac ggtttttatt ggagtcacaa tcaatgttat gcagaatact taatgatagg
    10801 attccaaatc agagctatag gaggtatata tgactacaat ccttatatcc gcttggcaga
    10861 agtacaatat aatgaacttg atttagaaga aactcaaatg tatcttgagc gtaacaatcc
    10921 tgaagaggct gaaaatatca aaatcctaaa aggcccaaaa ggggaattga ttatttcact
    10981 aaagaaaccg gccattccta acggatacaa gtattataat acggaggtaa atgaaaaaac
    11041 aaagcctaaa aaaatgatgg ccatttactt ggtgttcaac tcacctgtta acgttaaaag
    11101 cctacaagac agtaaaatgg acttttatat tgcaaaaact aataaaggac aagaaatcca
    11161 cttaaaaggt tatagcccgg tttattataa cagcaacgaa agttatgtaa atgaagacaa
    11221 ctttatatgg ggattaaaag tacctgcatc tttacatcat gccagagaag aagtaaactt
    11281 cttggaagca tatccagact ttgaacaatg ggtaacatcg ggaggtcaaa agaaccaaag
    11341 atggtggaat aagccaaaaa cgaataagtt gattatgaat taataaatat acagtaaatc
    11401 atatactgaa ttaaataaga ggtaaggtat gtcaatagat ttccttacct cttattttta
    11461 tcatatgaat tccatagaag tataaacaga taaatgctca ccatcaaatt ttgcagattc
    11521 tatcctatcc tttcctcttc aacaaatctg tcggactctc tccaaactgt tctctataac
    11581 atttagtaaa ataagaagga gaactaaaac caacttcata acctatctct gccactgtca
    11641 tatccgacga ggcaagcaga gaagcagctt tcttcaaacg agctatacga agcagttcat
    11701 tcggagaata attagtcaga gatttaatct tgcggtaaag ttgcacacga cttaatccca
    11761 tatccttacc caaatcttct acattcaaat ttgaatctcc catctttgcc tcaatcagag
    11821 ctttgaattt ttccacaaag tctttatcca tatcacagac atcctctttc gccaacgttt
    11881 gtccgtcacc aaaaaactgt ttcaggcggc ggtgtgaatc tatcagatta cgaacgcgtg
    11941 ccaatagtaa ttgcgaactg aaaggcttgg agatataaga atctgcacca ccatcatacc
    12001 cttgaattcg ttgttcatcc aaagaacaag ctgtcaatag gataacagga atatgacagg
    12061 tttgtaattc gcttttcaag cgacgacaac attcaattcc atccattccg ggcatcatta
    12121 catcggagat aatcaagtcc gggacatatt tcatagcttt acgaatacct tccgagccgt
    12181 ctgcagcttc tataacagta taatcagtgt gaagcaatcc atgcacatat aagcgaatat
    12241 cagcgttatc atcaataatc agaacgcaag gtttggaaga gtcgtaactt ttttccaatt
    12301 cctcttcttc gtaagttaaa gcatcattca agctcgaaga accggaataa ccagaagttg
    12361 caggagttac gggagcccca gcaacggcag aggttgcagc atcggtggag gttacagaag
    12421 tagcagggac agagaatgcc ggagagtttt cagaaacaac agtctcgcaa gtctgtacag
    12481 gcaaatcaac ggtaaagata gttccttgct tttcatcact ttccactgtg atggtacctt
    12541 tatgcaattc cacaaaagcc tttaccaatg ccagtccaat acccgaaccg gcatggtgca
    12601 tatctatctt atagaaacgg tcgaaaatat tccggatatg ctccgcagaa atcattgagc
    12661 cggtattggc aacagtaaag cgaatccaac aatgatcgtc tttagtcagg gaagataagc
    12721 gtacagttac ttttccattc tccggagtaa atttgaaagc gttggaaagg aggttgaaat
    12781 agatgcgttc caacttttct acatctgcca atgtgcggta atccgtatcc ggcatataat
    12841 cgaatgagaa atgaatatgt ttcttccggg ctgctgccat gaaagactcg ttccatccct
    12901 caaaagaaga aagaatgtct aacgaaatag gagtatattc catttttcca ttctcgtatt
    12961 tacgaaaatc cagaatctga ttgacaagac gcaagaggat attcacgttt cgctgaacta
    13021 acaataacat tcggcgctga tcttcactca aagacgaatc agccagtaaa tgctctaccg
    13081 ggtcggcaac taatgtcagt ggagtacgaa aatcgtgaga tatatttgtg aagaaaacca
    13141 gcttggcatg agtcgcttct tccagttgat gagaaagctg gataagctga tcccgctgtt
    13201 cttcgagttt gtcacgctgt tcttcaagaa tatcccgttg ctcttcgagt ttatcgcgct
    13261 gttgctctac ttgtttcttc tgttcggaca actctttatt caggcgattc ttggaacgga
    13321 gggatttata gactaccaac aacaatcccg ctactaataa aagaataacc aagccgccat
    13381 acatcacgac ctgctgcgta gctacacgcg acagataccc accgatacgt ccgttcaatg
    13441 tttcaatctt ctgatccagt tccgagatat gggtagtctg aagttgcata acgtgcgcgt
    13501 tcgtgcggtc tacaacggca gtattcatga ccgtttcgcg aggataagac ttcttctcaa
    13561 gaatattcat ggccagttgc atcactttgt ccccattagt cggataaata aaagttgcat
    13621 cgagcacatt gtcaagcacc aattcaagcc cgtttccttt gccgggcagg gcatcaatgc
    13681 caacaaaaat catttccttt tcacgtccgg ctttcttcgc agcctgatag gctcccggag
    13741 cgatacggtc gttatgtgca tacaccgcat caatcttcgg atgacggtga agcatactat
    13801 ccatttccac ttctgccggt tcacgttccc aggcagcatc cgctttatca atcagtttga
    13861 tatccggata attgctgata gcggccataa atccctgatg gcgctccata gcaggggtgg
    13921 aaccacccag tccggtaagc tccactacat tccctttccc tttcagactt gatgcgatat
    13981 aatttcctac cgcacgacct atttcataat tatcggcacc aatataggca gtatatttat
    14041 cagaaagtat cttccggtct acaagaatga caggtattcc tttctgatag gcctcctcca
    14101 caattggagt catgggagcc gcttcattgg cggaaattat cagtaaatca actcctttat
    14161 ctataaaata atgaacatct tccgcctgct tacggttatc atccgccgcc gaacggattt
    14221 caaccgacac tccatcataa aacatcgctt cgcgaagaat ctcatcattc atcttgtgcc
    14281 tccaagagtc atcgctacat tgggccaccc caatacggaa acgaggcgca tcctgccgac
    14341 aggccgccaa gcccaaaaga caaagcaaga ctgttatcca cttcgtatat ttcatcgctt
    14401 caatcattcc ctttctttcg tatatctttt gtatttcttt ctgtaatcca aatttctctc
    14461 cccgcattat ttgcattcac caccgggaaa tacatcagtt ccactttcac agggttcagc
    14521 gtatattttc cagtaaagcg tggaagcaaa ggaaccgtaa actgataagt acctaccggt
    14581 aatttttcgc taaagataac agttttctct ttaaaatact cacgatatac ttcagaacgg
    14641 gagaaattaa caggttttga ggcataacta caacctgccg gaacaggaac ttcgagcatc
    14701 acatattgcg caccctcctg tttcacctgc aaggtaactg tcaatgtaac aggtacaccc
    14761 gccaccaaag agtctttttc caaagtcacc tccaccttga aagcatcact ctgacgagca
    14821 ttcatcacac gcttcattga atagacacta tacaataaag gctcttttcc cgtttttgaa
    14881 ataagcagac tgtcgcctgc tgtcagccgg gcatgataag gaaattccgt aattcgttga
    14941 tgatccttac cgctcacaga caccgacgtt cctgacatcc ctccggaacc tgccagcaaa
    15001 tcggtcagaa cagttgccac agccgaagaa gcctgatacg tattccatcc gcgctcctta
    15061 gtccgcaaaa tatacaattg catattttct ttcaacttac acagggaagg gtcattttta
    15121 ataatccggt aggctatcaa tgtatttatc atctgatttc cctcccaata ataagtacgc
    15181 cgtccgtcgt cacagtaaac accttccagc atatcctttt tcagataagg acgtacgcta
    15241 tcacccacat tcaccgaatc cacctgttgc ttgatttccc agagaagcag cttctctttc
    15301 aagtatgaaa gaggacgata atacttgttt ctatttgcca acgagtcttc tttctgttcc
    15361 aattgccgga cgaaaggttc caataatctg actgccgaag aataatccgc ctctactttc
    15421 cactcatgca gagcatgaag tatttctata tcttccagtt tcattcctcg ataaggacgc
    15481 gtatgagcat actccacttt caaaccattc agattcaact ccacaggata acctgcatct
    15541 tgcgccatct tcaaagcccg cagaatatgc gcagacatcc agaaagaagt attttcagag
    15601 ttcccccacc acgaccataa ctgatgtttg ttctgatgat tcgtcagtcg atggatgata
    15661 ggtcgaattg ctttatctac tttcaccttt tcacccttac tctgcatata ctgttggtaa
    15721 gccaacaaac cggttaactt ggatgccagc tgctcattgc acaaatattt gtatcctgtc
    15781 aagtaattca ctgattcttt atagatgtcc aactgattgt cagtgatact caccatcact
    15841 tcttcatcct cgccggattg cactttgacc gtctttgcat cggacagaat acccaatgtg
    15901 ccctccgcca attcagttcc ctgtggcagt atcggaatcg tatattcctc tccatcctga
    15961 tagccatcgt cgcgagtgaa aagatagctg atggtcacgc tatcggcatg aactgcctgc
    16021 atcggcactg tttcatgaaa tccctccatg aaactcactt cctgccgttt caacgtatcc
    16081 gttccgacgc agaactgtgt ctttccggct atgtgctgcc catccagata attgcggata
    16141 gtcccgacca ccgtactctg atccccctcc accaagaagc ggggagtttt caactccgcc
    16201 atcaacggtt tgtaagagcg gacgaaacgt cggaaagtac ccgtctgcaa acgacggttc
    16261 atgccataaa cgacagtt
//
