LOCUS       gnlProkkaHNAKIJJP_71   12331 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HNAKIJJP_71.
ACCESSION   gnlProkkaHNAKIJJP_71
VERSION     gnlProkkaHNAKIJJP_71
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 05:23:23
            Original ID  :: gnl|Prokka|HNAKIJJP_71
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12331
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12331
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3017:7331]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3018..7331
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12331
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12331
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             2..1795
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 71.7;
                     E-value: 7.3e-22)"
                     /gene_kind="transport"
                     /locus_tag="ctg48_1"
                     /transl_table=11
                     /translation="MTTDPTSDIRLTLGNIRTIQINVMGEVVQPGTYALSSFSTVFHAL
                     YRAGGVSDIGSLRNVQLVRNGKNIATIDVYEFIMKGNTQDDIRLQEGDVVIVPAYDVLV
                     KISGKVKRPMRFEMKKDENLATLIKYAGGFEADAYTRSLRVVRQNGEEYEVNTVKDIDY
                     NIYKMRNGDVVTAEAILNRFTNKLEIRGAVYRPGIYQLSGKLNTIRELVHEAQGLTGDA
                     FLNRAVLYRQREDLTSEVVQIDIKSIMDGTSPNLALMKNDILYIPSIHDLEDRGNVTVH
                     GEVAHPDSYPYADNMTLEDLIIQAGGLKEAASTVRIDISRRIKNPRSTADNDTIGQMYT
                     FSLKDGFVIDGQPGFILEPYDQVYVRRSPGYQAQQNVAIEGEILFGGNYAMTSREERLS
                     DLVNKAGGPTNYAYLRGAKLTRVANASEKKRMGDVIRLMSRQLGEAMIDSLGIRVEDTF
                     TVGIDLEKALSNPKSNADLVLREGDVISIPKNTNTVTINGAVMVPNTVSYMKGKNVDYY
                     LNQAGGCSDNARKSKKFIVYMNGQVTKVKGSGKKQIEPGCEIIVPGKAKKKGNIANILG
                     YATSFSSLGMMIASIANLIKK"
     CDS             1806..2954
                     /locus_tag="ctg48_2"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             3018..3737
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.4e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             3758..5059
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.9e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 3e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3.4e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             5076..6200
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.6e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             6210..7331
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg48_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_6"
                     /sec_met_domain="Aminotran_5 (E-value: 2.3e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        6300..7307
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg48_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg48_6_Aminotran_5.1"
                     /locus_tag="ctg48_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             7328..7471
                     /locus_tag="ctg48_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             7674..9158
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_8"
                     /sec_met_domain="Polysacc_synt (E-value: 2e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             9112..10371
                     /locus_tag="ctg48_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             10380..11129
                     /locus_tag="ctg48_10"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             11129..12169
                     /locus_tag="ctg48_11"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 taatactacc gatcctactt ccgacatccg tctgacgtta ggtaatatcc gtactattca
       61 gattaatgtg atgggagaag tcgtacagcc cggtacctac gccctttctt ccttctctac
      121 cgtcttccat gcgctttatc gtgcaggcgg tgtgagtgat atcggtagcc tccgaaacgt
      181 tcagttggta cgcaacggaa agaatattgc caccatcgac gtctacgaat tcattatgaa
      241 aggcaacaca caggatgaca tccgcctaca ggaaggtgac gttgtgattg ttcctgccta
      301 tgatgtattg gtaaagatta gcggcaaggt aaaacgtcct atgcgttttg aaatgaagaa
      361 agacgagaac cttgctactc tcattaaata tgccggcggc tttgaagctg atgcctacac
      421 ccgttcatta cgtgttgtcc gtcagaatgg tgaggaatac gaagtcaaca cagtcaaaga
      481 tatagattac aacatttata aaatgcgtaa cggtgacgta gtaaccgccg aagccatcct
      541 taaccgcttc acaaacaaac tggaaatccg tggcgctgtc tatcgtcccg gtatctacca
      601 gctcagcggt aaactgaaca cgatccgcga acttgtccat gaagctcagg gtctgaccgg
      661 tgacgctttc ctgaatcgtg ccgtcctcta tcgccagcgt gaagacctga ccagtgaagt
      721 tgttcagata gacattaagt ctatcatgga cggcacttcc ccaaaccttg ccctaatgaa
      781 gaatgacatc ctctacattc caagtatcca tgacctggaa gaccggggta atgtcacagt
      841 tcacggtgag gttgcccacc ctgattccta tccttatgcg gataacatga cacttgagga
      901 tctgatcatt caggccggtg gcttgaaaga agccgcctct actgtccgta ttgatatatc
      961 gagacgaatc aagaatcctc gtagtactgc ggataatgat acgattggtc agatgtatac
     1021 cttctcttta aaggatggtt ttgtaataga tggtcagccc ggttttatcc ttgagcctta
     1081 tgatcaggtt tatgtccgtc gcagtccggg ctatcaggca caacagaatg tagccattga
     1141 aggtgaaatc cttttcggag gaaattacgc catgaccagc cgtgaggaac gtctttccga
     1201 tttagtgaat aaagccggcg gtccgaccaa ttatgcctat ctgcgtggtg cgaaactgac
     1261 ccgtgtggct aacgctagtg aaaagaaacg tatgggtgat gtaattcgcc ttatgagcag
     1321 gcaattgggc gaagccatga ttgactcttt gggtattcgt gttgaagata cttttacggt
     1381 tggaatagat ttggaaaaag ccttgagcaa tcctaaaagt aatgccgatc ttgtcttacg
     1441 tgaaggtgat gtgatctcca tacctaagaa tactaatact gtaactatca atggtgctgt
     1501 catggttccg aatacggttt cttatatgaa gggaaagaat gtggattatt acctgaatca
     1561 ggccggtggc tgttctgata atgcaaggaa gagtaagaag ttcattgttt acatgaatgg
     1621 tcaggtgacg aaggttaagg gtagtggtaa gaaacagatt gagccggggt gtgagattat
     1681 tgtgcctggt aaggctaaga agaaagggaa catagctaat attttaggtt atgctacttc
     1741 cttcagttct ttgggaatga tgattgcttc tattgctaat ttgataaaga aataaatgac
     1801 ctattatgat tgaaaagcaa tcttatcaag aaccgttttc tgaagtggat aaaaggaaag
     1861 atgatgaaat ggaaatagac ttgatggcta ttttttataa gattattact gttcgtggag
     1921 tactatgcaa agctgctgga gtgggagtaa taattgctat agtggtggca ttgagcattc
     1981 ccaagcaata tacagtaaag gttacccttt ctcctgaaat gggtaatgcg aagggaagta
     2041 atggtttagc cggacttgct gcctcgtttt tgggagatgg ggctctaata ggggaaagca
     2101 cagatgcctt gaacgcttct ctttcagcag atattgtttc ttcaactcct tttttattgg
     2161 aacttttaga aatggaagtc tccgtttcta aaaaggatga taaaatgact ttggggtctt
     2221 atctcgatga agagtcatct ccttggtggg attatcttat aggttttccg ggcatagtaa
     2281 taggaggagt taaatcatta ttcggagaag atacggttcc tgccagtgga gggcggcaag
     2341 gaactatcga attgacgaaa gaagtaaatg agaagattaa ttttcttaaa aagaagatta
     2401 gtgcatccat tgataagaaa accgccataa cgagcattac ggtcacctta caaaatccgc
     2461 agatcactgc ggttatagca gattctgtcg ttcataaatt acaggaatat attattgggt
     2521 atcgaacttc aaaagtaaaa gaagactgtg cgtatttgga acggttgttt aaagaacgtc
     2581 agcaggaata ttatgctgct caaagaaaat atgcggatta tgtagacgcc catgataatg
     2641 tggttcttca aagtgtacgt gctgagcagg agcgtttaca gaacgacatg agtttggctt
     2701 atcagatata tagtcaggtt gctaatcagt tgcaggtatc cagagccaaa gtacaggagg
     2761 aaaagccagt ctttgcagta gttgagcctg ccgttgtacc tttgaaacct tcaggtatgg
     2821 gactcaaaat ttatatttta ttatttgtgt tcctgtccgt atctggtact ctcgtgtggg
     2881 tgttttttgg caaaagtctg ctggctagct tgagaaaaga actgaaaaat aaggagatag
     2941 aacaggataa atgatgctaa aacgtcgttt acaacattct tacatcaatt aaattcactt
     3001 actatattat taaacgaatg atacgtacag ctatgataat ggctgcgggc atgggaaccc
     3061 gttttggcca atatacagaa ttgataccta aagggttcgt caaagtggga ggtattccaa
     3121 tgatagttcg ttctattgat actttgttat catgtgacat tgagcgaatt gtaatcggta
     3181 caggatataa acaagaagtt tatgaagaat tgaagacaga ctatcctatg cttgaaacct
     3241 gttttagtcc tcgttatgct gaaacaaata gtatgtatac tttatataat acgcgggaga
     3301 ttctgggcaa tgatgatttt ttattgttag agtcagattt gatttttgag aaacaagcaa
     3361 taatgagctt attggagtgt cctgcggcag atgcaatgct aataactcca gtgacaaagt
     3421 ttcaagatca gtattatgtg gaacatgatg ataattttcg cctttcttca tgttctgtca
     3481 ataagaataa actaaacgct aaaggcgaat tggtcggcat ccataaacta tccggttcct
     3541 tttacaaaat aatgtgtgct gattatgcga gtattgttga tgaacaaccc aatttgggat
     3601 atgagtatga attactacga atatcttgtt ctcaatctcc tgtttatgtg cataaagtag
     3661 aagggctgaa atggtatgaa atcgatgaca tatcagattt ggaatatgca gagaaatata
     3721 ttgttccgta ttgttaatta aaataatata tcaaattatg agtaagacag tttatattgg
     3781 gatgactgcg gatattatgc atccaggact tatccgcatt attaatgagg ctactaaata
     3841 cggtgatgtt ataattggtc ttcttacaga taaagctatt gcggagcata aacgccttcc
     3901 ttatctgacc tatgaacaac gaaaagaggt agttcagaat attaaaggcg tatgtaaagt
     3961 tgttcctcaa gaagaatgga gctatgttga gaatctcaaa cgcattaaac ctgactatat
     4021 aattcatggt gacgactgga aaaccgggcc tttacgtgaa gaacgtgtgc gcgtatttga
     4081 agtgatgaat gaacagggag gaaaggttat cgaaattcca tatactttgg gaattaattc
     4141 atcttctttg gataaagata ttaaggctat aggtacaacc cctgatgtac gtttaaaatc
     4201 acttcgtcgt ttgataaatg ccaaacccgt agttcgtatt ttggaagctc atgatggact
     4261 atgtggcttg ataattgaaa atcaggaaat attaaaaggg gataagaggg aagtatttga
     4321 cggaatgtgg tctagtagcc ttacggattc aaccagtaaa ggtaaacctg atattgaggc
     4381 ggttgattta actacccgat tgcaagattt gaataatatt ctggagtgta ctactaaacc
     4441 tattattttt gatggagata caggtggtaa aattgaacat ttcgtattta cagtacgcac
     4501 tttagaacgt catggaattt cagctataat aattgaagat aaagttggat taaaaaagaa
     4561 ttcattgttt ggtacagatg ttattcaaac tcaagataca atcgaaggtt tctgtaataa
     4621 gatcaaagca ggaaaggcat ctcagattac tgatgatttt atgattatcg ctcgtattga
     4681 gagccttata gcgggaaagc cggtaagtga tgctttagag agagcttttg catatgtcca
     4741 agcgggagcg gacggtatta tgatacatag caaaaataag tcgggtgaag atataaaaga
     4801 attttgtttg gcgtttcgaa aacagtatgc tcatgtacct atcgtggttg tgcctactac
     4861 atatgatcat atttatgagt ctgaattgtg tgattggggt gtgaatataa ttatttatgc
     4921 taatcatatg cttcgtgccg cttatcctgc tatgatgaat gtcgcaaaga taatattaga
     4981 gaatgaacgt gctttagagg tgcgcgaact gtgtatgccc ataaaagaaa tattggaact
     5041 gattccaggt actaaataaa aagaggaata tcattatgtt aagcgtagaa aaagtttatg
     5101 aaacgtttct gagtcatgac gttgattttt ttacaggagt tccagactca ttactaaaaa
     5161 atatttgtgc ctatatcaca gaccatactt cacgtgagaa acatatcata gctgctaatg
     5221 aaggtgcggc tgtaggaatt gcttcaggtt attatatggc atcaggtaag gttcctgtgg
     5281 tttatatgca aaattccggc ttgggtaata ctgttaatcc tctgctgtct cttgcagatg
     5341 aacaagtata cagttttcca atgcttttga tgattggctg gcgtggtgaa ccgggaacaa
     5401 aagatgaacc tcagcataaa aaacagggtg aggtaacttt agatttgttg aaagcaatgc
     5461 ggattcctta tataattctt gattcaaatg agaatgatgc atttattcag ctccatgata
     5521 tcatacaatc agcaaaaact aagaatattc ctcatgcaat aattattcgg aaagatgttt
     5581 ttggcaaata taaacttcaa aaagagttcg gatgtaatta tcctttatct cgtgaggatg
     5641 ctttgcaaat agttgtggat tatctgcctg aaaattcagt ggtcgtttct actactggca
     5701 agctttctcg tgagttattt gaatatcgag aaatgaaaga gcaaggtcat gaacatgatt
     5761 ttctcacggt aggctctatg ggacatagtt catcaatctc tttgggtatt gctatagcaa
     5821 agcaagatag acctgtttat tgcttggatg gtgatggagc atttattatg catttagggg
     5881 caattagtaa cattggcgat ttatctccta aaaactatta tcatattttg tttaacaatg
     5941 gtgctcacga gtctgtagga ggacagccta ctttaggatt tagtttagat attccggcta
     6001 ttgtccgggg gagcggatat aagcatactt atactgtttg tacaaaagtt gaaattgaag
     6061 aagcaatgaa gcagcttcca aagttatgtg gtcctgtttt gttggaaata aaggttaaaa
     6121 tagattctcg ggagaatttg ggacgtccca cgactactcc tatagagaat aaggagcatt
     6181 ttatggattt tttaaaataa atatattcga tgaaaataga aagaaaaata ttattaaatc
     6241 ctgggcctgc cactactact gacagtgtaa aaatggcaca agttgttccg gatatttgtc
     6301 ctcgcgagaa agaattcgca ggtatgatga aacaacttcg ggacgatttg gtcagagttg
     6361 ctcatgggaa tttggaaaaa cataccgctg tattattttg tggctcagga accatcaata
     6421 ttgatatatg tctaaattct cttcttcctg aagacaaaag ggtgcttata gtgaataatg
     6481 gggcatatag tacccgtgct gtagaagtgt gtcaatatta tggtttgcct catattaatt
     6541 tggaattttc cgtttacgaa cgtcctgatt tatcggtggt ggaaaatgtg ttgcaagaaa
     6601 atcctgatat agctatggtt tatactactc atcacgagac gggtacagga attctgaacc
     6661 ctattcgcga gatgggcgct atagctcata aatatcaggc taaatttgtc gtcgatacta
     6721 cttcttcttt gggcatgatt ccttttgata tagagaaaga taatgtggat ttttgtatgg
     6781 catctgctca aaaaggactt caagcgatga caggtctttc ttttattata ggcaatgagg
     6841 aacagattaa gttttcaaaa aaatatccca agcgttctta ctattgtaat ctttatttgc
     6901 agtatgagaa ttttgagaga acaggtgaaa tgcattttac tccaccggta caaactattt
     6961 acgccactcg tcaggcatta aatgaatatt ttgaagtggg tgaagaagct aagtttgccc
     7021 gtcacaaaag agtttttgag gctattcatt caggtataaa tgaaattggt cttaaaagtg
     7081 taataaagcg tgaatggcag tcaggactgg ttgtctcagt tcaataccca gaagatccca
     7141 actgggattt tgagaaaata catgattatt gttatgagcg tggatttacg atttatccag
     7201 gtaagatatc aactgaggat acttttagaa tctgtgcttt aggagagata gaagtagatg
     7261 atattgagaa cttctttaaa gtactaaaag ctgcattaaa tcattataac gtcacattac
     7321 cgatgtcatg attgcagaaa tattattgaa gattcgtcat ttttattttt cccttcgtgg
     7381 tatacacttc catccggaaa gtgttatttc tggagtgcct attcgtagct ttcgcttagt
     7441 aggcaaatat ggcaatatta atttgaggtg atgcattagg agttctttat tcttataaaa
     7501 aggcatcggt agttatagga gataatgttt gtgtagggta atttgctttt agtgggagag
     7561 accatattag aattgcggta aggggcgaag aagataataa ccaattagtg agaatattgg
     7621 aaaaatataa ttgatatcgg taaatgtagt tgtttttata ctgtatttaa gtaatggaaa
     7681 atctaaagca gaaaactgta tcaggaataa tgtggagcgc tatagaacgt ttctctttac
     7741 aaggagtaca gtttataatt caaataatat tagctcgttt gttactacca tcggattatg
     7801 gtatgatcgg gatgttagct atttttcttc aagtcgctca agtatttata gatagcggtt
     7861 ttacaaatgc tttaatccag aaaaaagata gaactgaaga ggattttgcc actgtctttt
     7921 attttaatat tcttgtcgca gtattattct atggtatatt gtttttttcg gcttctttga
     7981 ttgcagactt ttataatatg ccgactttag ttcttgtaat tcgttttata gcattgtcgt
     8041 tgataataaa tgctttatcg gctattcaca gaacgaaatt aattatttct gtaaacttta
     8101 aaactcaatc taaaatttca ttaggtgcag cttttatatc aggcgtgatt ggaatatgga
     8161 tggcttatgt cggttgcggg gtttgggctt tagtttggca aactctctta aatagtataa
     8221 ttttgacaat tttgttttac tgtttagttc attggaaacc tttacatact ttctccaaaa
     8281 gttcttttga aagattattc aatttcggat ctaaattatt gatctcaagt cttatcaata
     8341 cagtatatcg taatctgtat accattgtaa taggaaaaaa gttttctgtt gtagagcttg
     8401 gttactatac aagagcagaa caatttgcta tttttccttc caataattta aatgctttag
     8461 tttctagagt agcgtatcct attttaagtt ccattcaaga tgatgataaa tgtttaacaa
     8521 acgcatatcg aaattatatc agattatcct catatataat ttttccttta atggtaggtt
     8581 tacttgtttt ggctaatcct attattagtc tattgttaac agataaatgg tctggggttg
     8641 ttattctttt acagatatta tgtttggatt ggatgtttga tcatttgagc caaattaatt
     8701 tgaatttatt atgggttaaa ggaagatctg atctgtcgtt acgtcttgaa ataataaaaa
     8761 agacgattgc tatattcatt ctttttgtgt caattccatt tgggcttgag gtgatgtgtt
     8821 ggggtagagt tatttactct ctgatagcga catatttgaa tacatattat actaattctc
     8881 ttattgattt gaccttaaag ttgcaagtta aagatgtatt tccaagttta atactctctt
     8941 tcataatggg ggggatcgtt tttatatgta tttctttctt tgaaactgat atagtaaaaa
     9001 ttgtgattgg atgtattact gggatgtcct tctatatttt actttctttt ctttttaagc
     9061 tagattcttt tttttgtatt ttaacattga tcattaaaac taaaaacata gatgaaaata
     9121 ttaaaaaaga tttttcaagt aatagtaaag ataattaacc attgtgtgcc agttgatagt
     9181 agatcattgt attttattcc tcatcctaat tgtagaacag ataaatatga tattataaat
     9241 tattcgtcag ataatgttct cgttctgtta aattatttgc taaaaaaaga tagtgctgaa
     9301 tattataaaa tatatgttga aatttatgat tcttctcgta tttcagaata tcaagaatat
     9361 atttatggca taaatcctaa tattaggtgt acttttttat gtgcatgtgt tggacgtttt
     9421 ttctttaata aagtatcttt taaggatatg ttgtatgcct ttttttgttt ttgtagagca
     9481 agtaaatgtt ttacagctac tttttattat gatttttcat ttaaaaaacg ctctcaacag
     9541 attatttgtt tggggtatta tactccattc aaagatgatt atcatatggg agatcattct
     9601 tatgataaat ttcgtaatac aacatgtaac tcatttgatt actctattgc tacttcttgt
     9661 ttaagtgcta gaataatttc aatagattgt ggaatctcat atgataaatt caaagtctta
     9721 ggatttccca gaaatgattt gttgatatcg aaaaataatt gcaatgttat taaaagagaa
     9781 atttcgaaat ttgcgggata tgatgtaact aaatatatag tttatactcc aacttttcgt
     9841 gattatgaga ctgttactga aggtaatttg cgttcaatac tcggatatgt tgattgtgat
     9901 ttgttgaagt tatcgaaaat actattgaag tttaatgcgg ctttaattct taaattacat
     9961 cctttgcaga ataaaacagt cttaaaaaaa gatttaccca aaggtatact tgtttttgaa
    10021 caaacatata aatatggatt gtatgatctt ttgtcatttt cagatggaat gattactgat
    10081 tatacttcta cctattttga ttttttattg gtaaataagc cagtcatatt taatttctac
    10141 gatattgaag aatatcgtag agtaagaggt ttctcatttg agccaataga atttttttgt
    10201 gcaggtgata ttgtttacaa ttataatgaa ttgatagatg ctgtgatggg acttctggct
    10261 gggaaagata ttcatgctga acatcgacgt catatttctt tattgatgaa tcaatttcaa
    10321 gatgataatt caacaaagag aatatgtgac atatttttaa atgaaatata ataaataaaa
    10381 tgaattatgc atttgtggtg caggcacgtt taggttctac acgtttgcct ggaaaaatat
    10441 tgaaaccttt ctatggtaat caatcgattc ttgacttaat ggttcataag ctttctgcta
    10501 tatcgaatat tccagtaatt attgctacaa caaattctgt tatcaatgaa cctattgaaa
    10561 agaaggcact tgcattaggg gtaaagtgct tcagaggtga ggagaatgat gttttaaaac
    10621 gattcattga tgttgctgaa tattttgata tacagggtat attccgaata tgttctgata
    10681 atccattttt agatgtacat gcggcaaggc aattggtcga aatagcaatg aaatcttgta
    10741 acgattatat aagttttgat attgatggta ctccatcaat taaaactcat ttcggttttt
    10801 ggggagaatt tgtaacgctt gatgcgctga agcgagttat aggatttact gatgatttat
    10861 tgtatcgtga acatgttact aattatatat atagtcatcc tgaacttttt aatattcaat
    10921 ggatttcagg atctccagtc gtgtcaaaac atcataatat tcgactcacg attgatacgt
    10981 tagaagattt ttctgtagca cagagaatat atagggattt acaagaaaaa agagtggaaa
    11041 tatcgataga agtgattgta gactatgttc gaagacatgc agaatacatt caactgatga
    11101 aacaacaaat aaaaaaaaat tctaaataat gaagaatact tatattattg gtgaaatagg
    11161 gcagaatcat aatggttctg ttgacttggc taagttgatt attgaattaa tctcacgacc
    11221 tgtacatgag gatgtttttg gtatggattt catgccaatg aatgctgtta aaatgactaa
    11281 aagagattta tcagaagaat tggctgtttc tcaaatgaat caaatatatg acaatcctaa
    11341 ttcttttggg cgtacttatg gtgaacatcg tgcttttctt gagcttgatg atcaagcgca
    11401 ttttgagatt tataaatatg ctaagtcatt aggattagat tttatcgaga cgttatgtgc
    11461 caaaggatgt ctgtctttgc ttaaactgtt cacaccggat aggctaaaag ttgctagtcg
    11521 tgatttgact aacttaccat tgcttgaagc attagcagaa actcatattc ctattatatt
    11581 atcgacagga atggctggtc aaagagaact tgacaatgca ttagatgtga taacgagata
    11641 tcatagtaat atagctattc tacattgtgt atctcagtat ccaactcatc caaataattt
    11701 gaatctacgt acaataacat atttgaagaa gcattacaat aagtttgaga taggtttttc
    11761 tgatcataca ataggtattt ctgctgctac agctgctgta gcgatgggag cggaaattat
    11821 agaaaagcat gtaacaattg atcggcatat gaaaggaaca gaccagcttg gctctttagg
    11881 tccagatggg gttaatcgta tgattcgaga tattcgcata gcagagtgtt ggcttggtac
    11941 tgaagatctt tatatagaaa aaggggtgga gaagtctaag ataaaacttg aacgttctat
    12001 tgccactcga aaatatattc cagcaggtag tattattcaa gagtcggaca ttcatttact
    12061 gagtcctggt gatggttata aatggataga taaaaaaaat gtaattggtc attttgctaa
    12121 acaagatata tcagcgaatg aaataatata tcctgatttt attgaataga tatattccta
    12181 ctgcaacttg tattacggta tagagtactg cctgctataa gctaagtagt gattaataaa
    12241 taagggtaaa atactaaaaa aatgaaagag ataaagctta tacttacaga tattgatggc
    12301 gtttggactg atggcggaat gttttatgat c
//
