LOCUS       c00118_gnlPro..        15934 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JAJNCFGE_118.
ACCESSION   c00118_gnlPro..
VERSION     c00118_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 07:31:36
            Original ID  :: gnl|Prokka|JAJNCFGE_118
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 109
            Orig. end    :: 16043
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15934
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[10109:16042]"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..15933
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
     cand_cluster    1..15934
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /kind="single"
                     /product="acetate2butyrate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15934
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="acetate2butyrate"
                     /region_number="1"
                     /rules="(not (POR or POR_N or PFOR_II) and minimum(4,
                     [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF, ETF_alpha,
                     HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and minimum(1,
                     [EC1_2-faecali, ECH1_Enoyl_CoA_DH1, ECH1_Enoyl_CoA_DH2,
                     ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4, Thiolase_C]))"
                     /tool="gutsmash"
     CDS             complement(3708..4790)
                     /locus_tag="ctg118_2"
                     /transl_table=11
                     /translation="MQKLSQTEELARSLAAKAHRHTLTTEQISRAMEEADFDIAQLDEL
                     YAALEQRGVHLAEEEPAELPVLDDAQIGRLENELSSEGVALDDPVKTYLKEIGRVPLLT
                     AGQEMALAKAARAGDADARRALSEANLRLVVSVAKRYAGRGLPFLDLIQEGNLGLMKAA
                     EKFEPERGFKFSTYATWWIRQSITRAIADQGRTIRIPVHLVESINRVKKTAGDLLHKNG
                     REPTVEEIAAALDMEPDKVRELLQLSQEPISLETPVGEEEDAHLEDFIQDEDAGVPVDE
                     AGRQLLRRELLHVLKSLTPREERVITLRFGLEDGRARTLEELGKEFNVTRERVRQIEAK
                     ALRKLRHPSRAKLLRDYLDE"
     CDS             complement(4839..6614)
                     /locus_tag="ctg118_3"
                     /transl_table=11
                     /translation="MIPHEYIEELTRRTDIVELVGSYVQLKRKGRLYGGLCPFHSEKTP
                     SFYVYPDTQSFYCFGCQAAGDAISFVKKINNISSGEAIKMLASRAGMPEPQEDDKTGRL
                     RSRVLSMNKEAARFFHACLNSTVEEARQARAYWRRRGLDDKTIVRFGLGYAPNDGQALY
                     QYLRDKGYNQQELDASGLFKRSPSGRIYCLFWKRVMTPIFDLRGNIIAFGGRVMDDSKP
                     KYVNSPETLVYHKSETVFAMQIAKRSASRRFVLCEGYMDVISMQQAGIDTAVCACGTAL
                     TPGQVRIISEYADEVILSYDSDEAGQKATLRSLELFRNSPVKVGVLQIPGAKDPDEYIK
                     KYGPERFQALLDGVGNALDFRLKRLRDQYDLSQDAQRLQYVKEAVEMLAERSNPTEQEV
                     YAGRLAEETNISKTAILAQLGTAAKRAGGKYRREKNRELLRSGEMDQIKVPYSAGGSQA
                     LGIASAQQRLLAAILREPRYLELAKQQLTAEQFIQPQQKELYEAMLNCSREGVELSLTA
                     LRAFVSEEALNELSRLAAQYSDVNCTPDDIRLYLDRIARGMPVASKAAAMSGDEITQYL
                     QSMREKKQGTLPEQD"
     CDS             complement(6640..7638)
                     /locus_tag="ctg118_4"
                     /transl_table=11
                     /translation="MDVRRRTEEIEHLTFAPWATFSDASRGRVVPEPQDPLRPVFQRDR
                     DRVLHCKAFRRLKQKTQVFLSPEGDLYRTRLTHTLEVSQIARTIARGLRLNEDLTEAIS
                     LAHDLGHTPFGHAGEKALNALCPDGFHHYMQSLRVVDRLEKDGEGLNLTWEVRNGIVTH
                     TKGTWAATPEGRIVRLADQIAFVNHDIEDAVRAGVLGAATLPKHCTAVLGQTKSARITT
                     MINSILTHSEEDVRMGTEEYEAFLALRDFMYATVYVDKNAKREEQKVDKLIAELYEYYL
                     THVDQMSNFYVQLAYQEGRERAVTDYISGMSDEFAIRTFEELFVPQKWHVL"
     CDS             complement(7781..8401)
                     /locus_tag="ctg118_5"
                     /transl_table=11
                     /translation="VEDYRTVRGTATGEYEEKKSRFIAQLSFADSEEAAVAFLEQVRAA
                     NRTARHNVYAYRLRAGNRERYSDDGEPAKTAGTPALEVLQHSGLTDLIVVVTRYFGGVL
                     LGTGGLVRAYTTATARALENAEVVTVRSVVELQVTVDYALYERASLLIDAAGAKQAPPE
                     FTDRVTLRWQMPEHTEAPLLEQLRELTRGSAQVTVSDPFYAPF"
     CDS             complement(8515..9453)
                     /locus_tag="ctg118_6"
                     /transl_table=11
                     /translation="MKRAMSTVKNIAAAAMTLAVFFGFAGFKPVTANAAQAAMPATASV
                     EEENSYFEEDAYQRSFLTLINNERAQAGLAPVALGDSNHNAAAMERAEELAVSYSYVRP
                     NGQRDFTVLAENGISDVSIGENYMAGCSTPDSAMDQWMATDFTRERILNADATTVSVGY
                     YEGGVYNNYWVLIFSYPENSHTEDYRQEVLNLVNAQRAKYGLTALKMGDDALTAAAQTR
                     AEEISVVNSHVRPDGSKCFTVLKDYGVTDTPTGENAAWGSVSPEEVVNAWMNSEGHRAN
                     ILNPEARKMSVGYYYNSNSTWGHQWIQIFTK"
     CDS             9597..10079
                     /locus_tag="ctg118_7"
                     /transl_table=11
                     /translation="LQKKYRFFKKFSPFYRNSSVTKSPKTLQLCCDSRQNKPSATASAH
                     FLGHFGAFRFVYHCIYMHRFAYRGFCVRFCGASLCSLLRSFPVEQIGAAVQWLAQQLLY
                     KKHKKEAAAQKCATASHNSGYAIEQCSGTGDHRAAFAASICLISSGTTLNRSPTMP"
     CDS             complement(10001..11095)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF_alpha"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1009:Electron-transferring flavoprotein (Score: 111.7;
                     E-value: 4.4e-35)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg118_8"
                     /sec_met_domain="ETF (E-value: 3e-47, bitscore: 150.8,
                     seeds: 129, tool: rule-based-clusters)"
                     /sec_met_domain="ETF_alpha (E-value: 9.8e-36, bitscore:
                     111.7, seeds: 511, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADFNEYKGVWVFCEQRQGALMSTDFELVSEARKLADELGCKVTG
                     LLLGDNVEGIAKELGGYGADEVLVCDSPLLKDYTTDAYAKVVCDMVNEYKPEVLLIGAT
                     NIGRDLGPRCAARLHTGLTADATHLDIDTAKYIDFLKESSTIDLSKQKFDMEDRNLKMT
                     RPAFGGHLMATIICPRFRPQMSTVRPGVMKKAPFDQAKADACQIVKPAFSLTAEDIKTE
                     VLSVEKAAEKLVDLIGADVIVSVGRGISKDVNKGIELAEQLAAALGGGVVGASRAVTDA
                     GWMTADHQVGQTGKTVHPKIYVALGISGAIQHTAGMQDSECIIAVNKNEGAPIFGVADY
                     GIVGDLFKVVPELIKQIEAAKAAL"
     CDS             complement(11117..11911)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 157;
                     E-value: 1.6e-48)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg118_9"
                     /sec_met_domain="ETF (E-value: 3.5e-49, bitscore: 157.0,
                     seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAIVCVKQVPDTSGKVSVKPDGTLDRASMATITNPDDLNALEAA
                     LKLKDATGCEVVVVTMGPPPAEGMLRELLARGADKAVLVSGREFGGSDTFATSQILAAA
                     VNKIGVGPEDVVFCGRQAIDGDTAQVGPQIAEKLHLPQVTYVADIQKDGNTLTVKRMLE
                     DGYMMVKVQTPCLLTCIKELNDPRYMSVNGIFTCYDKPMEVFDYNALKDDPLIEVDTIG
                     LKGSPTNVFKSFTPPQKGAGTMLTGDDTAAQLAGILAKKHLI"
     CDS             complement(11929..13098)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg118_10"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 4.2e-50, bitscore:
                     159.8, seeds: 49, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 5.2e-30, bitscore:
                     93.5, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.5e-40, bitscore:
                     128.4, seeds: 796, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFTLSKQQQMVQKMYREFAENEVKPLAKKVDAEEYFPKETVEKM
                     GKLGMMGIYFPTEVGGAGGDVLSYVMAVEELSKVCGTTGVIVSAHTSLCAAPIYENGTP
                     EQKAKYLPKLCSGEWLGAFGLTEPGAGTDAQGQQTIAKEDGDYWVLNGSKIFITNAGFA
                     DVFIVIAVTDNVLDKRGRPTKLCSAFIVERTDPGFSVGKAEDKMGIRGSSTCELIFEDC
                     RIPKDRMLGVRGKGFQLAMATLDGGRIGIASQALGIAEGALEETIAYVKERKQFGRAIA
                     AFQNTQFELAEMKARVEAAKYLVYAAALKKQQAMDGAKVRYSVEAAQAKLIAARTASDV
                     TRRCLQLFGGYGYTRDYPIERMMRDAKITEIYEGTSEVQMMVISGALLK"
     CDS             complement(13101..13253)
                     /locus_tag="ctg118_11"
                     /transl_table=11
                     /translation="MDFTLSKQQQMVQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
                     XXRRI"
     CDS             complement(13360..14232)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg118_12"
                     /sec_met_domain="HCDH (E-value: 1.1e-34, bitscore: 109.0,
                     seeds: 68, tool: rule-based-clusters)"
                     /sec_met_domain="HCDH_N (E-value: 2.2e-61, bitscore: 196.7,
                     seeds: 60, tool: rule-based-clusters)"
                     /sec_met_domain="F420_oxidored (E-value: 7e-08, bitscore:
                     23.0, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIGVIGAGTMGQGIAKAFAQVEGNTVALCDIKQEWAENGLAKIK
                     KGYEKLVAKGKMTQEKADAIVAAITPGLKEDLCADCDLVVEAAFEDMKVKQTTFGELDK
                     ICKPECVFASNTSSLSITEIGKGLTRPLIGMHFFNPADRMKLIEVIAGCNTPAETVEKI
                     KEIAVAIGKSPVQVNEAAGFVVNRILIPMINEAAFIKMEGVSDIAGIDTAMKLGANHPM
                     GPLELGDFIGLDICLAIMDVLYNETGDSKYRACPLIRKMVRGGNLGCKTGKGFYVYNAD
                     RTKTPVDQL"
     CDS             complement(14275..15060)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: EC1_2-faecali"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg118_13"
                     /sec_met_domain="EC1_2-faecali (E-value: 7e-94, bitscore:
                     303.6, seeds: 67, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAFVKTEVQGAVEIITIDRPKALNALNPEVLADLKAAFEAVDQET
                     VRCIVLTGEGDKSFVAGADIGSMSTMTKAEGEAFGKLGNDVFLMIEHFPIPVIAAVNGF
                     ALGGGNELAMSCDFRICSDNAVFGQPEVGLGITPGFGGTQRLARLVGMGMAKQLVYSAL
                     NIKADEAYRIGLVNAVYPQAELMENVLKLAGKIAKNAPIAVRNCKKAINDGISLPIEKA
                     VEVEEKLFGDCFETHDQKEGMACFLSREKPKPKAVFTNN"
     CDS             complement(15184..15933)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Thiolase_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Thiolase_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg118_14"
                     /sec_met_domain="Thiolase_N (E-value: 1e-38, bitscore:
                     123.0, seeds: 30, tool: rule-based-clusters)"
                     /sec_met_domain="Thiolase_C (E-value: 2.2e-49, bitscore:
                     156.2, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="GFNKHMGMTAENVCTNETYQKKYGYSPITREMLDEFSYNSQLKAD
                     KAIKDGAFKDEIVPVVIKGKKGDTVFDTDEGPRLSAPEVLAKLKPAFTKDGIVTAGNSS
                     AINDGAAALVVMSEEKAKELGVKPLATWVAGALAGVEPEVMGLGPIAATKKVMAKTGMT
                     VADMDLVEANEAFAAQSIAVGEALGFDKDKLNVNGGAIALGHPVGASGARILVTLLYAM
                     KHRGAHKGLATLCIGGGMGCATIVEMD"
ORIGIN
        1 ctcgatcttg gagaagtcga tgatgtggcc cttctcgccc atgatcttgg ggagcttggt
       61 ggggtatgca ggtgcattct caccgtgcca catctcgcgg gcggtatcaa aggtatcacc
      121 gatgtcgttc tcacgggcag agtcaaagac aggggtcatg accttgatgc cgcaggcctt
      181 ggcagcgtag ccaaggttga cttccagcac ctgaccgata ttcatacggg aaggcacgcc
      241 cagcgggttc agcacgatat ccagcggagt gccgtcgggc aggtagggca tatcctcctg
      301 cggcaggatg cgggaaacga cacccttgtt accgtgacgg cctgccatct tatcgccgac
      361 gctgatctta cgcttctgag cgatatagca gcggacgacc tcgcgcacac cgggctgcag
      421 ctcgtcgctg ttctccgggg taaagacctt gacatccaca atgatgccgt atgcgccgtg
      481 aggcacacgc agagaggtgt cgcgcacctc gcgggccttc tcgccgaaga tggcgcgcag
      541 caggcgctcc tcagcggtca gctcagtctc gcccttcggg gtgaccttac cgaccagaat
      601 atcgccgctc ttgacctcgg cgccgatgcg gatgatgccg cgctcgtcca gatccttcag
      661 ggcatcctca gaaacattgg ggatgtcgcg ggtgatctcc tcgggtccca gcttggtatc
      721 gcggctctcg gtctcgtact cctcgatgtg gatggaggtg tacacgtcct cacgcacgat
      781 cttctcgttc agcaggacgg cgtcctcgta gttgtagccc tcccaggtca tgaagccgat
      841 cagggcgttc ttacccagag agatctcgcc gttgcgcatt gcggggccat cggccagcac
      901 ctgaccggcg gtgacggtct cgcccacttc tacgatgggg cgctggttga tgcaggtgcc
      961 tgcgttggag cgggcaaact tgatcagaga ataatcctcc agagcgccct gctcgttgcg
     1021 caccacaaca tggtcggcat cgaccttttc cacaacgccg ttgctcttgg ccagcacagc
     1081 agtgccggaa tcggtagcag ccttgtactc cataccggta gcaacaatgg gctgctgggt
     1141 gaccatcaga ggcactgcct gacgctgcat gttagagccc atcagtgcac ggttacagtc
     1201 atcgttctcc aggaagggga tgcaagcggt agcaacagag accatcattc gcggagaaac
     1261 gtccatgtaa tcgaccttct ctgcgtcgat ttccaagatc tcgtcgcggc ggcgggcaga
     1321 cacacgggga cggatgaagt gcttgccttc atccagcggc tcgttggcct gtgccacaac
     1381 gtactcgtcc tccacatcgg cggtcatata ctccacctcg tcggtgacga cctgctcgat
     1441 gagattgttg ttctcgtcgt agatcttctt gaccttgcgg tagggagcct ccacgaagcc
     1501 gtactcgttg atcttggcgt aggatgccag ataggagatc agaccgatgt tggggccttc
     1561 aggggtctca atggggcaca tacggccata gtggctgtaa tgaacgtcgc ggacttcgaa
     1621 gcctgcgcgg tcacggctca gaccgccggg gcccagagca gacagacggc gcttgtgggt
     1681 cagctcagcc agagggttgt tctgatccat gaactgagac agcggagagg agccgaagaa
     1741 ctccttgatg gctgccacca caggacggat gttgatcagt gcctgcggag tgatgacgct
     1801 ctgatcctga ctctgcaggg tcatacgctc acggatgacg cgctccatac gggagaaacc
     1861 gatgcggaac tggttctgca gcagctcgcc cacgctgcgg atacggcggt tgcccagatg
     1921 gtcgatatca tcggtggtgc cgatgccgta gcccagaccg ttcaggtagt tgatagagga
     1981 caggatatcg tcgatggtga cggtacggcc aatgagcagg tcgtgatcct tcttcaggct
     2041 ctccatgacc tcctcggcgc tggaggcgtt atcaaggatc ttgcgcagct ccttgaggca
     2101 gcagcgctcg ttgatgccgc actccttgac atccacaccc ttgaatgcgg ggtagtagct
     2161 gtcgatgatg gcctgtgcgt ccacgcagcc gttggtgatg accttgacct tgtggggctg
     2221 atccttcatg ggatcatcga tcttcagcac gaccagattc acgccggcag catcgatctg
     2281 ctcagccagc ttgcggtcga tcttcttgtc ggcctcgaca aggatctcgc cggtgaaggg
     2341 atccaccacg ttctctgcgg ccacatggtc catgatgcgg cgtgccagag acagcttctt
     2401 attcatctta tagcggccga aacgggacag gtcgtaccgg cgcggatcga agaacagcat
     2461 atcgatctgg ctggtagcgg actccaccgt ggggggctcg ccggggcgca gcttgcggta
     2521 gacctccagc aggccctcct cgcggttctt ggtggtatcc ttttccagcg tggccagaat
     2581 gcgctcgtcc tcgccgaagt agttcaggat atcctcgtta gaggacaggc ccagtgcacg
     2641 gcacagcacg gtgacgggca gcttacggtt cttatcgata cggacataga acacgttggc
     2701 ggcatcggtc tcgtactcca gccatgcacc gcggttgggg ttcatggtgg cgctgtacag
     2761 gtcgttgccg accttatcct tagcatggcc gtagaacaca ccgggagagc ggaccagctg
     2821 gctgacgatt gcacgctcgg caccgttgat gacaaaggtg cctgcgtcgg tcatcagggg
     2881 gaagtcaccc atgaagatct cctgatcctt cacctcgccg gtctccttgt tcagcagacg
     2941 ggcagtgacg cgcagggggg ctgcaaaggt aacgtcgcgc tccttgcact ccttgatgct
     3001 gtacttcggc tccttatcca gccggaagtc cacaaagctc agtgccagat tgccggtgta
     3061 gtcctcaatg gtgccgatat cgtggaagac ctccttcagg ccttcatcca ggaaccactg
     3121 atacgagttc ttctgcacct cgatcaggtt cggcatactg atgacttcgt cgatgtggga
     3181 gaagctcatg cgctcggttt tgccgagctt tacgggcttg actttcatca taaaatcaac
     3241 cactccttac ttttatattc tacgggatgt cgtatacgcg ggtcaaattt gagcagacac
     3301 acataattcg acccgcgtcc tgcggaacct tccggcattt tgcacaaact tttcggggtg
     3361 acccctcaag cggcagccat cacagttccc tttttgacgc actagtccat tatgtgatac
     3421 taatgtagta tacaccccaa aacccctgtt gtcaagccat ttttcagttt tttgccgaaa
     3481 taaatttaat tttcggtttg ttttcgaacg cccggcagcg tgtagtcgtt tgttttccaa
     3541 gtacttgatt tttttatttt gcacgttcct gttcataata cccttgtgca atttgtctat
     3601 ctttgctctt gcgcccggag gtattacttt tccgcttccc tgccgcaaaa agaagagacc
     3661 gccgcacgga acgccgtgca gcggccttgt cctattatat agaatgctca ctcgtccaga
     3721 taatcccgca gcagctttgc gcggctgggg tggcgcagct tgcgcagcgc ctttgcttcg
     3781 atctgccgca cccgctcccg ggtcacgttg aactccttgc ccagttcttc cagggtgcgg
     3841 gcgcggccat cctccagacc aaagcgcagg gtgatgaccc gctcctcccg gggcgtcagg
     3901 cttttaagga cgtgcagcag ctcccgccgc agcagctgac gcccagcttc atccaccggg
     3961 acaccggcgt cctcgtcctg aataaagtcc tccagatggg cgtcctcttc ctcccccacc
     4021 ggcgtttcca gactgatggg ttcctgcgac agttgcaaca gttcccgcac cttgtccggc
     4081 tccatatcca gtgcggcggc gatttcctcc acggtgggct cccgcccatt tttgtgcagc
     4141 aggtcgcctg ccgttttctt gacccggttg atgctctcca ccagatgcac cgggatacgg
     4201 atggtacgtc cctgatccgc aatggcgcgg gtgatggact gacggatcca ccaggttgcg
     4261 taggtggaga acttgaagcc ccgttccggc tcaaactttt cagcagcctt catcaggccg
     4321 aggttgccct cctgaatgag atccagaaaa ggtagtccac gcccggcgta gcgcttggct
     4381 accgatacca ccagccgcag gtttgcctcg ctcaaagcgc ggcgggcatc tgcatccccg
     4441 gcccgggcag cctttgccag cgccatctcc tgtccggcgg tcagcagcgg cacccggccg
     4501 atctccttta aataggtctt gaccggatca tccagtgcca caccctccga ggatagttca
     4561 ttctccagcc tgccgatctg ggcatcatcc agcacaggca gctcggcagg ctcctcctct
     4621 gccagatgaa cgccccgctg ctccagcgcc gcgtaaagct cgtccagctg tgcaatatca
     4681 aaatccgctt cttccatggc acggctgatc tgctccgtgg tcagggtgtg acggtgagcc
     4741 tttgcggcaa ggctgcgggc aagttcttcc gtttgcgaca atttctgcat gattcctgct
     4801 ccttttctct ccagctccag ccggagggaa aacagggatc agtcttgttc gggcagcgtc
     4861 ccctgctttt tttcgcgcat cgactgaaga tactgtgtga tctcatcgcc agacattgca
     4921 gcagctttgc tagcaaccgg cattccccgg gcgatcctgt ccagatacag acggatatcg
     4981 tccggagtgc agttcacatc gctgtattgt gccgcaagcc ggctcagttc attcaatgct
     5041 tcttcgctta caaatgcccg cagtgcagtc aggctgagtt ccacgccctc ccggctgcaa
     5101 ttgagcatcg cttcgtatag ttccttctgc tgcggctgga tgaattgctc cgccgtcagc
     5161 tgctgcttgg ccagttccag atagcgcggc tcccgcagga tagctgccag cagccgctgc
     5221 tgggcgctgg cgatgcccag cgcctgactg ccacctgcgc tgtacgggac cttgatctga
     5281 tccatctcgc cggagcgcag cagctcgcgg tttttctccc ggcggtactt gccgcccgcc
     5341 cgctttgctg cggtgcccag ctgcgccaga atggcggttt tggagatgtt ggtctcctct
     5401 gccagccgcc cggcgtacac ctcctgctca gtggggttag agcgctcggc cagcatctcc
     5461 acggcttcct ttacatattg cagccgctgc gcatcctgcg agagatcata ctggtctcgc
     5521 aggcgcttga gccggaagtc caacgcattg cccaccccgt ccagaagtgc ctgaaaacgc
     5581 tccgggccgt attttttgat gtattcgtcc gggtcctttg cgccgggaat ctgcaaaacg
     5641 cccaccttta ccgggctgtt gcggaacagt tccagtgagc gcagggtcgc cttctggcca
     5701 gcctcgtccg agtcatagct cagaatgacc tcatcggcat actcgctgat gatgcgcact
     5761 tgcccggggg tcagggcggt gccgcaggcg cagacggcgg tgtcgatgcc cgcctgctgc
     5821 atactgatga catccatgta gccctcgcac agcacgaacc gccgggaggc gctgcgcttt
     5881 gcgatctgca tggcaaacac cgtctcggat ttgtggtaga ccagcgtttc cgggctgttg
     5941 acgtatttgg gcttggagtc gtccatcacg cgcccgccaa aggcaatgat attaccgcgc
     6001 aggtcaaaga tgggggtcat gacgcgcttc cagaacaggc agtagatgcg gccggaggga
     6061 ctgcgcttga acaagccgct ggcgtccaac tcctgctgat tgtagccctt atcccgcagg
     6121 tactggtaca gtgcctgccc gtcattgggg gcatagccca gcccgaaccg gacgatggtc
     6181 ttatcgtcca gcccgcgccg ccgccagtaa gcgcgcgcct gccgtgcctc ctccacggta
     6241 gagttcagac aggcgtggaa gaagcgggcg gcctccttgt tcatggaaag cacccggctg
     6301 cgcagacgtc cggtcttgtc gtcctcctgc ggctccggca taccggcgcg ggaagccagc
     6361 atcttgatag cttcgccgct gctgatattg ttgatctttt tgacaaagct gatggcatct
     6421 ccggctgcct gacagccgaa gcagtaaaag ctttgggtgt cagggtacac atagaaggac
     6481 ggcgtttttt cgctgtgaaa agggcacaga ccgccgtaca gacgtccctt gcgcttgagc
     6541 tgcacatagc tgcccaccag ttccacaatg tcggtgcggc gggtgagctc ctcgatgtat
     6601 tcgtgtggga tcatgttgat ttaaacgacc tctccagttt taaaggacgt gccatttctg
     6661 gggcacgaac agttcttcaa aggtgcggat ggcaaactcg tcgctcatac cgctgatgta
     6721 gtcggtgacg gcgcgttccc gtccctcctg ataggccagc tgcacataaa agttggacat
     6781 ctgatccaca tgggtcaggt agtactcgta cagttccgcg ataagcttgt ccaccttctg
     6841 ctcctcgcgc ttggcgtttt tgtccacata cacggtggcg tacatgaaat cccgcaaagc
     6901 gagaaaagcc tcgtattcct cggtgcccat gcggacatct tcctcgctgt gggtgaggat
     6961 gctgttgatc atagtggtga tgcgggcgga cttagtctgc cccagcactg ccgtacagtg
     7021 cttgggcagg gtggcagcgc ccagcacacc ggcgcgcacg gcgtcctcga tatcgtggtt
     7081 cacaaaggcg atctgatccg caagacgcac gatgcgccct tccggggtag ccgcccatgt
     7141 gcccttggtg tgggtaacga tgccgttgcg cacctcccat gtcaggttaa ggccctcgcc
     7201 gtccttttcc agccggtcta ccacacgcag gctttgcata taatggtgga agccgtccgg
     7261 gcagagagcg ttcagtgcct tttcgcctgc gtgtccaaag ggagtgtgcc ccagatcatg
     7321 cgcaaggctg atggcctcgg tcagatcctc gttcaggcgc agaccccggg caatggtgcg
     7381 ggcgatctgc gaaacttcca gcgtatgggt caaccgggtg cggtacaggt caccttccgg
     7441 cgagaggaac acctgcgttt tctgcttgag acgccggaag gccttgcagt gcagcacccg
     7501 gtcgcgatcc cgctggaaca ccgggcgcag cgggtcctgc ggctccggca cgactctgcc
     7561 gcggcttgca tcgctgaagg tcgcccacgg tgcaaaggta aggtgttcga tctcctcggt
     7621 tctccgacgc acatccatac agatcctcct tttgtttttc gggcttctcc cctcccctct
     7681 gcgcacagcc gatcccaatt gctgcgctac ggcaattgta gcacatcggc cgtgtcgaag
     7741 ggggaagttc cgtgtcggtt tgcaaaaaag actttgtttt ttaaaatggt gcgtagaacg
     7801 ggtcagacac cgttacctga gcgctgcccc gggtcagttc ccgcagctgc tccagcagcg
     7861 gggcttcggt atgctccggc atctgccagc gcagggtgac ccggtctgta aactccggcg
     7921 gtgcctgctt tgccccggcg gcgtcaatga gcagagatgc acgctcgtaa agggcgtagt
     7981 ccactgtcac ttgtaattcc accacgctgc gcacagtgac cacctcggcg ttttccagcg
     8041 cacgggcagt ggcggtagtg taagcgcgca ccaagccgcc ggtgcccagc agcaccccgc
     8101 caaagtagcg ggtgaccacc acgatcaggt ctgtcaggcc gctgtgctgc aacacttcca
     8161 gcgcgggcgt accggcggtc ttggccggct cgccgtcatc ggaatagcgc tcgcggttgc
     8221 ccgcccgcag gcggtaggcg taaacattgt gccgcgcggt gcggttggct gcccgcacct
     8281 gctccagaaa ggccacagcg gcttcctcac tgtcagcaaa ggaaagctgt gcgataaagc
     8341 ggctcttttt ctcttcgtat tcaccggtgg ccgtgccccg gacggtgcgg taatcctcca
     8401 cgttagatcc tcctgataat aactcagaat aagtataaca caaacgggcg caaataaaaa
     8461 gactgacgaa gccttgcggc cccgccagtc tttttataag aagaaagcag ttaatcactt
     8521 ggtaaagatc tggatccact gatgacccca agtgctgttg ctgttgtagt agtaaccaac
     8581 actcatctta cgagcctcag gattcaggat gttagcacga tggccttcgg agttcatcca
     8641 tgcattgacg acttcttcag gagagacgct gccccatgcg gcattctcgc cggtgggggt
     8701 atcggtgacg ccatagtcct tcaggacggt gaagcactta gagccatcgg gacggacgtg
     8761 ggagttcaca acggagatct cctcggcgcg ggtctgtgca gcggcggtca aagcgtcatc
     8821 gcccattttc agagcagtca gaccatactt tgcgcgctgg gcattgacca gattcagaac
     8881 ttcctgacgg taatcctcgg tgtgagaatt ttcggggtaa gagaagatca gcacccaata
     8941 gttattgtaa acaccgccct catagtagcc aacgctcacg gtggtagcat cggcgttcag
     9001 gatacgctcg cgggtgaagt cggtagccat ccactgatcc attgcggaat cgggggtgga
     9061 gcagccggcc atgtagttct cgccgatgga gacatcgctg ataccgttct ctgccagaac
     9121 ggtgaaatcg cgctgaccgt tgggacgaac gtaggagtaa gaaactgcca gctcttcggc
     9181 acgctccatt gcagcggcgt tgtggttgct gtcgcccaga gcaacaggag ccagaccagc
     9241 ctgtgcacgc tcgttattga tcagagtcag gaagctgcgc tggtaagcgt cttcctcaaa
     9301 gtaggagttc tcttcttcca cagaagcggt ggcaggcatg gcagcctgtg cagcgtttgc
     9361 ggtgacgggc ttgaagcctg caaagccaaa aaacacagcc agcgtcattg cagctgctgc
     9421 gatattcttc acggtactca ttgcacgctt cataagattg cctccggtct gttgccttat
     9481 gcagtgtgat cttggatatt gcaactcgtt tgcaactctg tcgtatcaca tccgcaactc
     9541 ttgtgtaaca agagtatcac aaaaccatac agacgtcaag aggtttagag gttgatttgc
     9601 agaaaaaata cagatttttt aaaaaattct cgccttttta tcgcaactca agcgtaacaa
     9661 agagtccgaa aacgttacag ttatgttgcg attctcgcca aaacaagcca agtgcaacag
     9721 cttccgcaca ctttttgggg cacttcggtg cgtttcgttt tgtatatcac tgtatttata
     9781 tgcaccgctt tgcatatcgt ggtttctgtg tacgtttttg tggcgcttcg ctgtgttccc
     9841 ttctgcgttc ctttcctgtg gagcaaatcg gagctgctgt gcagtggctg gcacaacagc
     9901 tcctttataa aaaacacaaa aaagaggccg ctgcacaaaa atgtgcaacg gcctctcaca
     9961 attcaggcta tgctattgaa caatgctcag gaacaggcga tcacagagca gcctttgctg
    10021 cctcgatctg cttgatcagc tcaggcacga ccttgaacag atcgcccacg atgccgtagt
    10081 cagcaacgcc gaagatggga gcaccctcgt tcttgttgac agcgatgatg cactcagaat
    10141 cctgcatacc ggcggtgtgc tggatagcac cagagatacc cagagccaca tagatcttgg
    10201 ggtgcacagt cttgccggtc tgaccgacct gatggtcagc ggtcatccag cctgcatcgg
    10261 tgacggcacg ggaagcgccc acgacaccgc cgcccagagc ggctgccagc tgctcggcca
    10321 gctcgatgcc cttgttgaca tccttgctga taccacgacc aacggagaca atgacatctg
    10381 cgccgatcag gtcgaccagc ttctcagcgg ccttctccac gctcagcact tcggtcttga
    10441 tgtcctcagc ggtcaggctg aaggcgggct tgacgatctg gcaggcatca gccttggcct
    10501 gatcgaaggg agccttcttc ataacgccgg gacgcacggt ggacatctgg ggacggaagc
    10561 gggggcagat gatggtagcc atcagatggc cgccgaatgc gggacgggtc atcttcaggt
    10621 tgcggtcttc catatcgaac ttctgcttgg acaggtcgat ggtggagctc tccttcagga
    10681 agtcgatata ctttgcagtg tcgatatcca gatgggtagc atcggcggtc aggccggtgt
    10741 gcagacgggc tgcgcagcgg gggccgaggt cacggccaat gttggtagcg ccgatcagca
    10801 gcacctcagg cttgtactcg ttgaccatat cgcacacgac ctttgcgtat gcgtcggtgg
    10861 tgtaatcctt cagcagggga ctgtcgcaga ccagaacctc gtcggcacca tagccgccca
    10921 gttccttggc aatgccctcc acgttgtcgc ccagcaacag gccggtgact ttgcagccca
    10981 gctcgtcggc cagcttacgg gcctcgctaa ccagctcgaa gtcagtggac atcagtgcgc
    11041 cctggcgctg ctcgcaaaag acccatacgc ccttgtattc gttaaaatca gccattgtaa
    11101 tcctatgctc ctttcatcag atcaggtgct tcttggccag gatacctgcc agctgtgcgg
    11161 cggtgtcgtc gccagtcagc atggtgcctg cgcccttctg cggaggagtg aaggacttaa
    11221 agacgttcgt cggagaaccc ttcaggccaa tggtgtccac ctcgatcagc ggatcgtcct
    11281 tcagtgcgtt gtagtcaaac acttccatgg gcttatcgta gcaggtaaag ataccgttca
    11341 cgctcatgta gcgggggtcg ttcagctcct tgatgcaggt cagcaggcag ggagtctgca
    11401 ccttgaccat catgtagccg tcctccagca tacgcttcac ggtcagggtg ttgccgtcct
    11461 tctggatgtc ggcaacgtag gtgacctgcg gcagatgcag cttttcagcg atctgggggc
    11521 cgacctgtgc ggtatcgcca tcgattgcct gacggccgca gaacacaacg tcctcggggc
    11581 caacgccgat cttgttgacg gcagcagcca ggatctggct ggttgcaaag gtatcggaac
    11641 cgccgaactc acggccggag accagaacag ccttatcagc gccgcgggcc agcagctcac
    11701 gcagcatgcc ctctgccggc gggggaccca tggtgacaac aacgacctcg cagccggtgg
    11761 cgtccttcag tttcagggcg gcctccagag cgttcaggtc atcggggttg gtgatggttg
    11821 ccatggatgc acgatccaga gtgccatcgg gcttgacgga caccttgccg gaggtatcag
    11881 gaacctgctt tacacaaaca attgctttca ttgtaactct tgcctccctt acttcagcag
    11941 cgcgccggaa atgaccatca tctgcacttc gctggtgccc tcgtagatct cggtgatctt
    12001 ggcatcacgc atcatgcgct cgatggggta gtcacgggtg tagccgtaac caccgaacag
    12061 ctgcaggcaa cggcgggtca catcgcttgc ggtgcgggcc gcgatcagct tagcctgtgc
    12121 agcctcgacg ctgtaacgaa cctttgcgcc atccatagcc tgctgcttct tcagagcggc
    12181 agcataaacc agatacttag cagcctcaac acgagccttc atctcagcca gctcgaactg
    12241 agtgttctgg aaagcagcaa tagcacggcc gaactgcttg cgctccttga cgtaagcaat
    12301 ggtctcctcc agagcgccct cggcgatgcc cagagcctga gaagcgatgc cgatacggcc
    12361 gccatccagc gtagccattg ccagctggaa gcccttgccg cgcacgccca gcatacgatc
    12421 cttcgggata cggcaatcct caaagatcag ctcacaggta gaagaaccgc ggatacccat
    12481 cttgtcctct gctttaccaa cagagaagcc cgggtcggtg cgctccacga tgaaggcgga
    12541 gcagagcttg gtgggacggc cgcgcttatc cagcacgtta tcggtaacgg cgatgacgat
    12601 gaacacatca gcaaagccgg cgttggtgat gaagatcttg gagccgttca gcacccagta
    12661 atcgccatct tccttggcaa tggtctgctg gccctgtgcg tcagtgccag cgcccggctc
    12721 ggtcaggccg aaagcaccca gccactcgcc gctgcacagc ttcggcaggt acttagcctt
    12781 ctgctcgggg gtgccgttct cgtaaatggg ggcagcgcac aggctggtgt gagcagagac
    12841 gatgacaccg gtggtgccgc agaccttgct cagctcctcc acggccataa cgtaggacag
    12901 cacatcgccg cctgcaccgc cgacctcagt cgggaaatag atgcccatca tgcccagctt
    12961 gcccatcttt tcgacggtct ccttggggaa gtattcctct gcgtcaacct tctttgccag
    13021 aggcttgact tcgttctcag caaactcgcg gtacattttc tgcaccatct gctgctgctt
    13081 ggacagagta aaatccatcg ctatatcctc ctnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13201 nnnnnnnnnn nnttctgcac catctgctgc tgcttggaca gagtaaaatc catcgctata
    13261 tcctcctaac aggtcttttt tcatttaccg gaatagcccg gtgcaaacaa attcctcccg
    13321 accgctttcc ccgcagccgg gagaaatgtt tatcagaatt tacagctggt caacaggggt
    13381 cttggtgcgg tctgcgttgt aaacgtagaa gcccttaccg gtcttgcagc ccagattgcc
    13441 gccacgcacc atcttgcgga tcagcgggca ggcacggtac ttgctgtcgc cggtctcgtt
    13501 gtacagcacg tccataatgg ccaggcagat gtccagaccg atgaagtcgc ccagttccag
    13561 gggtcccatg gggtggttag cgcccagctt catggcggtg tcgatgccag cgatatcgga
    13621 aacgccctcc atcttaatga aggcagcctc gttgatcatg gggatcagga tgcggttgac
    13681 cacaaagccg gcagcctcgt tgacctgaac ggggctcttg ccgatggcaa cggcgatctc
    13741 cttgatcttc tcaacggtct cagcgggggt gttgcagccg gcgatgacct cgatcagctt
    13801 catgcggtct gcggggttga agaagtgcat accgatcagg ggacgggtca gacccttgcc
    13861 gatctcggtg atggacagag aagaagtgtt ggaagcaaag acgcactcgg gcttgcagat
    13921 cttatccagc tcaccgaagg tggtctgctt gaccttcata tcctcgaaag cagcctcaac
    13981 gaccagatcg cagtctgcgc acagatcttc cttcagaccc ggggtgatgg cggcgacgat
    14041 cgcgtcagcc ttctcctggg tcatctttcc cttagcgacc agcttctcgt agcccttctt
    14101 gatctttgcc agaccattct cggcccactc ctgcttgatg tcgcacagag caacggtgtt
    14161 gccctcaacc tgtgcaaatg cctttgcgat gccctgaccc atagtgccag cgccgataac
    14221 accgatcttc ataggaaatc tctcctttaa tatcaaaaat tatgtagtaa tggattagtt
    14281 gttggtgaac actgccttgg gcttcggctt ctcacggctc aggaagcagg ccatgccttc
    14341 cttctggtca tgagtctcga agcagtcgcc gaacagcttc tcttcgactt cgacagcctt
    14401 ctcgatgggg aggctgatgc cgtcgttgat agccttcttg cagttacgca cagcgatggg
    14461 agcgttcttt gcgatcttgc cagccagctt caggacattc tccatcagct cagcctgcgg
    14521 atacacggcg ttgaccagac cgatgcggta agcctcgtca gccttgatgt tcagcgcaga
    14581 gtagaccagc tgctttgcca tgcccatgcc gaccagacga gccagacgct gggtgccgcc
    14641 gaagcccggg gtgatgccca gaccgacttc cggctgaccg aacacagcgt tgtcagagca
    14701 gatgcggaaa tcgcagctca tagccagctc gttgccgccg cccagtgcaa agccgttgac
    14761 ggctgcgatg acggggatgg ggaaatgctc gatcatcagg aacacatcat tgcccagctt
    14821 gccgaaggcc tcgccttctg ccttagtcat ggtgctcata gaaccgatat cagcaccagc
    14881 aacgaagctc ttgtcgcctt cgccggtcag aacaatgcag cggacagtct cctgatcgac
    14941 tgcctcaaaa gcagccttca ggtcagccag aacctcgggg ttcagggcgt tcagtgcctt
    15001 gggacggtcg atggtaatga tctcaacagc gccctgcacc tcggttttta caaatgccat
    15061 tgtgaaaacc tccatttcat acagttcagt tttttcaaaa cagcccccgg aacgcgggag
    15121 agctctccgg ttccctccgg cgctccgggt ctgtggttca gtcaggattc agagaaagag
    15181 tgcttagtcc atctcaacga tggtagcgca gcccatgccg ccgccgatgc acagggtagc
    15241 cagacccttg tgagcgccac ggtgcttcat agcgtacagc agggtgacca gaatacgagc
    15301 gccggaagcg ccgaccgggt gacccagagc gattgcgccg ccgttgacgt tcagcttgtc
    15361 cttatcaaag cccagagcct cgccgacagc gatggattgt gctgcgaatg cctcgttggc
    15421 ctcgaccaga tccatatcgg caacagtcat gccggtctta gccatgacct tcttggtagc
    15481 agcgatgggg cccagaccca tgacctcggg ctcaacgcct gccagagcac cggcgaccca
    15541 ggttgccaga ggcttcacgc ccagctcctt agccttctcc tcgctcataa cgaccagagc
    15601 agcagcgccg tcgttgatgg cggaagagtt accagcggtg acgatgccgt ctttggtgaa
    15661 ggcgggcttc agctttgcca gaacctcggg agcgctcaga cggggaccct catcggtatc
    15721 gaacacggtg tcgcccttct tgcccttgat gacaacagga acgatctcgt ccttgaaggc
    15781 gccgtccttg atggccttgt cagccttcag ctggctgttg tatgagaact cgtccagcat
    15841 ctcgcgggtg atggggctgt agccgtactt cttctggtag gtctcgttgg tgcagacgtt
    15901 ctcagcggtc atgcccatgt gcttgttgaa gccg
//
