LOCUS       gnlProkkaHKHAAPHC_87    4733 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HKHAAPHC_87.
ACCESSION   gnlProkkaHKHAAPHC_87
VERSION     gnlProkkaHKHAAPHC_87
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 05:37:20
            Original ID  :: gnl|Prokka|HKHAAPHC_87
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 4733
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..4733
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[3020:4250]"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3021..4250
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..4733
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..4733
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     CDS             complement(2..349)
                     /locus_tag="ctg87_1"
                     /transl_table=11
                     /translation="MKRKTSPHQAALTDRTTIKVRFSEIDSMQIVWHGEYVRYFEDGRE
                     AFGKRYGLDYMSIYREGYVVPIVDLTCQFKQPLSFGEEAIVETRFIHSDAAKILFEYTI
                     YRASDQNIVATG"
     CDS             complement(346..783)
                     /locus_tag="ctg87_2"
                     /transl_table=11
                     /translation="MSSKEIICQGEELFRLIPQRPPMVMIDRFYGIEENTSWSGLTVTT
                     DNLFCRDGVLQETGIIEHIAQSAAARVGYIYMLRKEPVPLGFIGSVEKMKLFRLPSAGA
                     ELYTGITIVQEVFDITLITAEVKENDELLAECRMKIYLKKE"
     CDS             complement(780..1850)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 117.8; E-value:
                     1e-35)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg87_3"
                     /transl_table=11
                     /translation="MMHKRYTKEQCTAAEAQRLAQEIAFGPVVFQVSRLMLKFGIFQLL
                     SGKREGYTLQEISGQTGLTRYAAQVLLEASLTIGTILLEEDRYVLAKAGWFLLNDKMAR
                     VNMEFNHDVNYQGLFHLEEALLNGRPEGLKVFGEWPTIYEGLSQLPEQVQKSWFGFDHF
                     YSDQSFGKALEIVFSHHPKRLLDIGGNTGRWATQCVQYNKEVEVTIVDLPQQLEMMRKQ
                     TAGLSGSERIHGHGANLLDRDVPFPTGFDAVWMSQFLDCFSEEEVISILTRVAQSIGKD
                     SKVYIMETLWDRQRYETASYCLTQISLYFTAMANGNSKMFHSDDLIRCIENAGLEVEEI
                     QDNIGLGHSILQCRLK"
     CDS             complement(1864..2748)
                     /locus_tag="ctg87_4"
                     /transl_table=11
                     /translation="MSETWKGKTRGGIFGYMFFIYMIRCLGITAAYGFLALVVLYFIPF
                     APKATGNTWSYARNRLKYGRLKSVALLLKNYYRLGQILIDKVAIGNGMTGKYHFKFENY
                     QAFLDVLNGNTGVIMIGAHVGNWEIGAPFFDEYGKKINIVMFDAEHKRIKEILEKNAST
                     RDYKIIPVNEDSLTHVFRITEALDRREYVCFQGDRYLNKEKLLTTSFMGKEAKFPMGPF
                     LLASKLKVPVVFYFAMREAQRTYRFHFFIAETVVRTKEKRAEQALLEQYTQTLEKIVRQ
                     YPEQWFNYYPFWT"
     CDS             complement(2748..2999)
                     /NRPS_PKS="Domain: PP-binding (7-74). E-value: 4.3e-14.
                     Score: 44.7. Matches aSDomain:
                     nrpspksdomains_ctg87_5_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg87_5"
                     /sec_met_domain="PP-binding (E-value: 5.4e-15, bitscore:
                     44.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNEEIIEKIRTTLAEEFEIDVEQIQPDAPLMQTLELDSLDLVDM
                     VVLIDKNFGFTVTAKDFAGIKTFQDFYNLVISHMQKED"
     aSDomain        complement(2778..2978)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg87_5_PP-binding.1"
                     /evalue="4.30E-14"
                     /label="ctg87_5_PP-binding.1"
                     /locus_tag="ctg87_5"
                     /protein_end="74"
                     /protein_start="7"
                     /score="44.7"
                     /tool="antismash"
                     /translation="EKIRTTLAEEFEIDVEQIQPDAPLMQTLELDSLDLVDMVVLIDKN
                     FGFTVTAKDFAGIKTFQDFYNL"
     CDS             complement(3021..4250)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (77-405). E-value:
                     6.6e-51. Score: 165.4. Matches aSDomain:
                     nrpspksdomains_ctg87_6_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 309.4; E-value:
                     6.6e-94)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg87_6"
                     /sec_met_domain="APE_KS1 (E-value: 5.6e-172, bitscore:
                     560.8, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRVVITGMGIYSCIGKNQDEVKDSLFQGRSGIGIDPARKEMGYF
                     SALTGLVERPDLKKLLDRKKRHSLAEQGEYAYMATLEAFRQAQIDEEFLLDHEVGILYG
                     NDSSAAPVIEAIDVIRAKKNTAMVGSGSIFQSMNSTITMNLSVIFHLKGINFTISGACA
                     SGSHAIGMAYMLIKSGLQDCILCGGAQEVNPYSVGSFDGLGAFSTREDEPEKASRPFDK
                     GRDGLVPSGGGASLVLESYESAVRRGATILAEVIGYGFSSNGDHISVPNVDGPRRSLQM
                     AINDAGIPLEEIQYINAHATSTPVGDLNEAKAIAEVFGNHRPYVTSTKSQTGHEMWMAG
                     ASEVIYSILMMNNGFIAPNLNFEEPDEASALLNIPSRRIETEFDTFLSNSFGFGGTNSS
                     LIIRKFKENN"
     aSDomain        complement(3036..4019)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg87_6_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="6.60E-51"
                     /label="ctg87_6_PKS_KS.1"
                     /locus_tag="ctg87_6"
                     /protein_end="405"
                     /protein_start="77"
                     /score="165.4"
                     /tool="antismash"
                     /translation="MATLEAFRQAQIDEEFLLDHEVGILYGNDSSAAPVIEAIDVIRAK
                     KNTAMVGSGSIFQSMNSTITMNLSVIFHLKGINFTISGACASGSHAIGMAYMLIKSGLQ
                     DCILCGGAQEVNPYSVGSFDGLGAFSTREDEPEKASRPFDKGRDGLVPSGGGASLVLES
                     YESAVRRGATILAEVIGYGFSSNGDHISVPNVDGPRRSLQMAINDAGIPLEEIQYINAH
                     ATSTPVGDLNEAKAIAEVFGNHRPYVTSTKSQTGHEMWMAGASEVIYSILMMNNGFIAP
                     NLNFEEPDEASALLNIPSRRIETEFDTFLSNSFGFGGTNSSLIIRKF"
     CDS             complement(4258..4731)
                     /NRPS_PKS="Domain: PKS_KR (1-86). E-value: 2e-08. Score:
                     26.2. Matches aSDomain: nrpspksdomains_ctg87_7_PKS_KR.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     148.5; E-value: 3.9e-45)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg87_7"
                     /transl_table=11
                     /translation="MNNAGIRRDNLMLWMEQDEWSRVLDISLNGFFNVTQPLLKNMLVK
                     RFGRIINIVSLSGIKGMPGQTNYSAAKGGMIAATKALAQEVARKHVTVNAVAPGFIRTD
                     MTNGIDENEWKKQIPAGRFGEPGEVAALVGFLASEQASYITGEVISINGGIYT"
     aSDomain        complement(4474..4728)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg87_7_PKS_KR.1"
                     /evalue="2.00E-08"
                     /label="ctg87_7_PKS_KR.1"
                     /locus_tag="ctg87_7"
                     /protein_end="86"
                     /protein_start="1"
                     /score="26.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="NNAGIRRDNLMLWMEQDEWSRVLDISLNGFFNVTQPLLKNMLVKR
                     FGRIINIVSLSGIKGMPGQTNYSAAKGGMIAATKALAQEV"
     CDS_motif       complement(4519..4569)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg87_7_0001"
                     /evalue="2.00E-05"
                     /label="PKSI-KR_m4"
                     /locus_tag="ctg87_7"
                     /protein_end="71"
                     /protein_start="54"
                     /score="17.1"
                     /tool="antismash"
                     /translation="SLSGIKGMPGQTNYSAA"
ORIGIN
        1 ttcctgttgc cacaatgttt tggtccgatg cccggtagat ggtgtattca aaaagaattt
       61 tggcggcatc actgtggata aaccgtgtct cgacaatcgc ttcctcgcca aaagacagcg
      121 gttgtttgaa ctggcaggtc aggtctacga taggaactac atatccttcc cggtagatgc
      181 tcatatagtc cagaccgtat cgctttccga aagcttcgcg tccgtcttcg aaataacgca
      241 catattctcc atgccatact atctgcatgg aatctatctc actgaagcgg actttgatgg
      301 tggtccggtc cgtcagtgcc gcctgatgtg gacttgtttt tcgtttcatt ctttcttcag
      361 atatattttc atccggcatt cggccagcaa ttcatcgttt tcttttacct cggcggtaat
      421 cagggtgata tcaaatactt cctgaacgat ggttataccg gtatatagtt ctgctccggc
      481 agaaggaaga cggaatagtt tcatcttttc taccgaaccg ataaaaccta atggtacagg
      541 ttctttccgc agcatataga tataacctac acgtgccgcc gccgactggg cgatgtgctc
      601 tatgattccc gtttcctgta atacaccgtc ccggcagaac aggttgtcgg tagtgacggt
      661 cagccctgac caggatgtat tttcttctat cccatagaag cggtctatca ttaccatggg
      721 cgggcgttgg ggaatcagcc ggaacagctc ttctccctga cagatgattt ctttgctgct
      781 catttcagtc tgcattgcag gatactgtgt cccagtccta tgttatcttg aatttcttcc
      841 acttccaatc cggcattttc aatgcagcgg atcaggtcat ccgaatggaa catcttactg
      901 ttgccgttgg ccattgctgt aaagtagagg ctgatttgtg tcaggcaata agatgctgtt
      961 tcataccgtt ggcgatccca taatgtttcc ataatataga ctttgctgtc tttgccgatg
     1021 gattgtgcca cacgggtcag gatgctgatg acttcttctt ccgagaagca gtccagaaac
     1081 tggctcatcc atacagcgtc aaaacccgtg ggaaagggca cgtcccgatc cagcagattg
     1141 gcgccgtgac cgtgtatgcg ttcactaccg gacaaaccgg ccgtttgctt tctcatcatt
     1201 tccagttgtt gaggcaggtc cacgatggtt acttccactt ccttattata ttgtacgcat
     1261 tgtgtggccc atctgccggt attcccgcca atatcgagca agcgtttcgg gtgatggctg
     1321 aacacgattt ccaacgcttt gccgaatgac tggtccgaat agaaatgatc aaagccgaac
     1381 cagcttttct gtacctgttc cggcaattgg gacagacctt cgtaaatggt aggccattct
     1441 ccgaatactt tcaatccttc cggacgcccg tttaaaagag cttcttccaa atggaacaag
     1501 ccttgatagt tcacatcgtg attgaattcc atattgacac gagccatttt atcgttcagc
     1561 agaaaccagc ctgccttggc cagtacataa cggtcttctt ccaacaggat ggttccgatg
     1621 gtcagcgatg cttccagtaa tacttgtgcc gcatagcgtg tcagtccggt ctgcccgctg
     1681 atttcttgca gcgtatatcc ttcccgtttg ccggacaata attggaaaat tccgaatttc
     1741 aacatcaggc gcgatacttg gaataccaca ggaccgaaag ctatctcttg tgccagtctt
     1801 tgcgcttcgg cagccgtaca ttgttctttt gtatatcttt tatgcatcat accagattta
     1861 tttttatgtc cagaacgggt agtaattgaa ccattgttcc ggatactgcc ggacaatctt
     1921 ttccagcgtt tgtgtatatt gctccaataa tgcctgttcg gcccgtttct ctttcgtccg
     1981 tactactgtc tcggctataa agaaatggaa acgatacgtt ctttgggctt cacgcatggc
     2041 aaaatagaat acgacgggta cttttaactt cgaagccagc aggaaagggc ccatcggaaa
     2101 tttggcttct tttcccatga aagaagtcgt gagtaatttc tctttattca gatagcggtc
     2161 tccctgaaag cagacatact cccggcggtc cagcgcttcc gtgatgcgga atacatgtgt
     2221 caggctgtct tcattcaccg gaattatttt gtagtctcgc gtagaggcgt tcttttccaa
     2281 aatctccttt atccgcttgt gttcggcgtc aaacatgacg atattgatct ttttgccata
     2341 ttcatcgaag aaaggagcgc ctatttccca gttgcccaca tgggcgccaa tcataattac
     2401 tccggtgttt ccgtttagta cgtctaaaaa tgcctgatag ttctcaaact tgaaatgata
     2461 cttgccggtc attccgttgc cgatggccac tttgtcaatc aatatttgtc ccagccggta
     2521 atagtttttc aggagcagtg cgacggattt cagccgtccg tatttcagcc tgttccgtgc
     2581 gtaactccaa gtattgcccg ttgctttcgg tgcgaaaggt atgaagtaga ggacgaccaa
     2641 tgccaggaag ccgtaggccg cagttatccc cagacagcgg atcatgtaga taaagaacat
     2701 gtatccgaat atgcctcctc ttgtcttacc tttccatgtt tcggacatca gtcttctttt
     2761 tgcatatgtg aaattaccag attatagaaa tcttggaagg ttttgatacc ggcaaaatct
     2821 ttggctgtaa cggtgaaacc gaaattcttg tcaatcagta ctaccatatc caccaggtca
     2881 aggctatcca attccaaggt ttgcatcaaa ggtgcgtccg gttggatctg ttctacatca
     2941 atctcaaatt cttcggccag ggtggttctg atcttttcga tgatttcttc gttggtcata
     3001 aatttatata ttggtttgaa ttaattgttt tctttaaatt tacggataat cagtgaggaa
     3061 ttggttcctc cgaatccgaa tgagttggac aagaaggtgt caaattccgt ttctatcctc
     3121 cgggagggga tgttcagcag agcagaggct tcatcgggtt cttcaaaatt gagattagga
     3181 gcgataaatc cgttattcat catcaagatg gaataaatga cttcactggc gcctgccatc
     3241 cacatctcat gtccggtttg tgacttggtg gatgtgacat agggccgatg gtttccgaac
     3301 acttccgcta tggcttttgc ctcattcaaa tctcccacgg gggtggaagt ggcgtgtgca
     3361 ttgatatatt ggatttcttc caagggaatg cccgcatcgt tgattgccat ctgtaaagag
     3421 cgtctgggac cgtccacatt cggtacggaa atatgatctc cgtttgatga gaaaccgtat
     3481 cctatgactt ctgccagaat agtagctccg cgccttacgg ctgattcata actttcgagt
     3541 accaggctgg cgcctcctcc gctgggtacc aaaccgtccc gtcccttgtc aaaggggcgc
     3601 gatgcctttt ccggttcgtc ctcacgggtg gagaacgcgc ccaatccgtc gaaactaccc
     3661 acggagtaag gatttacctc ttgtgctcct ccgcacagaa tgcagtcctg aagtcctgat
     3721 ttgatgagca tatacgccat gccgatggcg tgtgaaccgc tggcacaagc tcccgatatg
     3781 gtaaaattaa ttcccttcaa atggaaaata accgaaaggt tcatggtaat cgtagagttc
     3841 atggactgga agatagaacc ggagcctacc atagccgtat tcttcttggc acgaatgaca
     3901 tcaatggcct cgattaccgg agcggcgcta ctgtcatttc catacaatat gcctacttca
     3961 tgatccaata aaaactcctc gtctatttgt gcctgacgga atgcctccaa ggtagccata
     4021 taggcatatt ctccctgttc ggcgaggcta tgccgctttt tgcggtccaa taacttcttt
     4081 aaatcaggac gttcgacaag tcctgtcaat gcggaaaaat accccatctc tttacgtgcc
     4141 ggatcgatgc cgatgcctga acgcccttgg aacaaagagt ctttcacctc atcttggttc
     4201 ttgcctatgc acgaataaat acccatgcct gtaatcacta ctcttctcat cttctgctta
     4261 tgtatagatt cctccattga tggaaattac ctctccggtg atataggagg cttgttccga
     4321 tgccaggaag cctaccagtg cggctacttc tccgggttcg ccgaaccgtc ctgccggtat
     4381 ctgttttttc cattcatttt catcaatgcc gttggtcata tccgtgcgga taaatcccgg
     4441 tgctacggcg ttcaccgtca cgtgttttct ggccacttcc tgtgccagtg ctttggtggc
     4501 ggctatcatt ccgcctttgg ctgccgaata gttggtttgt cccggcattc ctttgatacc
     4561 cgacagggaa acgatgttga tgatacgtcc gaatcgcttt accagcatat ttttcagcaa
     4621 gggttgggtg acgttgaaga aaccgttcag gctgatatcc aacacccggc tccattcatc
     4681 ctgttccatc cacagcatca ggttgtcacg gcgtataccg gcattgttca cca
//
