LOCUS       c00169_gnlPro..        14142 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HKHAAPHC_169.
ACCESSION   c00169_gnlPro..
VERSION     c00169_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 11:18:40
            Original ID  :: gnl|Prokka|HKHAAPHC_169
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14142
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14142
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[74:4142]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      75..4142
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14142
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14142
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             75..482
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg169_1"
                     /sec_met_domain="HBT (E-value: 3.1e-14, bitscore: 43.4,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMEETTCKPDYSNSMAEHLGIRFLPSTEDAVHAEMPVDHRTSQPF
                     GMLNGGASLALAEIVAGHGSTSLCREGEYACGVQVSGNHLSAVPVGGKVFATGKLIHRG
                     RSSHIWNIDITTPQGQLVSTVRVVNFILKKK"
     CDS             479..1621
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg169_2"
                     /sec_met_domain="Chorismate_bind (E-value: 3.8e-58,
                     bitscore: 187.2, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLPDIHTQKLLDCLTHSRLGFALYRLPWTDECYLVLQTSGDVEQ
                     LADIQELNGKKGFVMAPFRISEEHPLVLIRPDVTAYDWSEISEALSSLECADALLTCKS
                     RQSELSPFVSEETDKEQYTRAFGRFITPLQEKRFQKLVLSRSSARHIRDDFSPLGAFVR
                     ACNNYPRMMIYLCHTPASGTWLGSTPEILLSGHGKEWHTVALAGTMPMQNEVMPTDWDK
                     KNREEQGYVADYIRRIAKRFGNKMTEKGPYTARAGQLVHLKTDFYFLLKNTDHIGDLLQ
                     ELHPTPAVCGLPKEEAFRFIPDNEGYDRSYYSGFTGWLDTEGHTDIYVNLRCMEIKPGE
                     AILYAGGGILASSEVESEWMETGDKMNTMRSILHPDFINK"
     CDS             1648..3321
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg169_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.6e-07, bitscore:
                     21.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLKAHGVRKIVLCPGSRNAAIVHTLANIEDFT
                     CYSVTDERSAGFFAIGLSLQGGGPAAVCCTSGSALLNLHPAVAEAFYQQVPLIVISADR
                     PAAWIGQMDGQTLPQPHVFGTLVKMSVNLPEVHTEEDEWFCNRLINEAILETTHHGKGP
                     VHINVPISEPIYRFTAKTLPEVRVITRYQGLSVYDRDYKELIERLNKYNKRMVVVGQMN
                     LIYLFEKKYVKPLYKHFAWLTEHLGNQTIPGIPIKNFDAAVYSMTPERQEDMAPEILIT
                     YGGHIVSKQLKKYLRNHPPREHWHVAADGKIADLYGCLTTVIEMDPFEFLEKIAFLLDN
                     KPTHYPLMWENYCKTIPMPDLAYSEISVIGKLIRALPEPCALHLANSSTVRYAQLFTVP
                     PQVEICCNRGVNGIEGSLSTAIGYAAASSKLNFIIIGDLSFFYDMNALWNQNYGANIRI
                     LLLNNEGGEIFHTLPGMDKSSRSREFITAEHYTTAKGWAEERGFIYMKVTGEEELEEAM
                     QPFTSPETRMQPMLLEVFTDKEKDTTLLREYYHGLKNKNE"
     CDS             3321..4142
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg169_4"
                     /sec_met_domain="ECH_1 (E-value: 7.8e-85, bitscore: 274.3,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METREWKTIKEYQDILFDFYNGIAKITINRPRYRNAFTPTTTSEI
                     SDALYYCRECQDINVVVLTGAGDKAFCSGGDMHVKGHGGYIGTDGVPRLNVLDVQKQIR
                     SLPKPVIAMVNGYAIGGGHVLHVVCDLTIASENAIFGQTGPKVGSFDAGFGSSYLARIV
                     GQKKAREIWFLCRQYSAQEALEMGLVNTVVPFYRLEDETVAWAEKMMEHSPLALRMIKA
                     GLNAELDGQAGIQELAGDATMLYYMTEEAQEGGKAFLEKRKPRFQDYPKFP"
     CDS             4163..4546
                     /locus_tag="ctg169_5"
                     /transl_table=11
                     /translation="MDIEEFRKYCLSLGDVSEKMPFGKFAARYDSILAFYVYGHMFCFI
                     DIDNFTFVNVKSTSDEIEYIKERHVSVGNPINQSLKHWLQLNFDGDIPDTSIYTWVQRA
                     FEIVRDKYTKPTTHKKKCSKPKL"
     CDS             4525..5580
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg169_6"
                     /sec_met_domain="MR_MLE_C (E-value: 6.6e-30, bitscore:
                     94.4, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQTQIIKKQLHFKQPAGTSRGVYTTRDVWYILLTDTGSRHYGVG
                     ECAPLPALSCDDIPSYDEVLATACKNLEKNGEIDREALLPYPSILFGMETALLHFRARS
                     LQFWHTPFSKGKEGIPINGLIWMGNFDEMYRRIGEKMQQGFRCIKLKIGAIDFEKELEL
                     LAHIRRHFTPAQIELRVDANGAFSPADALEKLHRLSEFQLHSIEQPIRAGQWDEMARLC
                     AATPFPIALDEELIGINRRDRKIELLETIRPQYIILKPSLHGGISGSEEWMELAAERGI
                     GSWVTSALESNIGLNAIAQWCATLQPALPQGLGTGLLFTDNIDYPLHIEGDCLWFHPEE
                     QEPDLLNWLKQ"
     CDS             5577..6662
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 55.3; E-value:
                     1.4e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg169_7"
                     /sec_met_domain="AMP-binding (E-value: 3.8e-18, bitscore:
                     55.3, seeds: 145, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding_C (E-value: 1.8e-08, bitscore:
                     25.5, seeds: 272, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKFCTNRNKQTILIESIPYSNWEIEMVRMNIPADNRSFRQELFS
                     FLSEWFDPADTLPVHTSGSTGKPKELYVEKERMMESACLTCSFLGLQKEDSALLCMPLQ
                     YIAGKMVVVRALVAGLDLLPVTPSGHPLKDLTKAPVFAAMIPMQVYNSLQVPEEKAILQ
                     QIRHLIIGGGPIDSQLNAALKDFPHAVWSTYGMTETLSHIALRRLNGPEASDWYTPFES
                     IQIRLSKENTLVIYAPEICEKELVTNDIAEINGQNQFRILGRKDNTINTGGVKVQIEQV
                     EAALKEHLSVPFLITSAPDEKFGEIIVLLAEGQLPDDIEQTCTHQLPPYWRPKRFVPVF
                     KLPLTETGKPDRAIAKLLAQK"
     CDS             6918..7802
                     /locus_tag="ctg169_8"
                     /transl_table=11
                     /translation="MLYNNPKPQDTKEGLSDQDFSIYMDAHTVPFSKYPSYMPAGVLGI
                     CTEGNAEIQVGLRKYVICANDILIFMPGFLVSFIKSSPTFTIDYCTFSNVLFYDVINGS
                     IKRFPTGFHTYTQTHCVYSLSQEKAELFSIYFRLLYNRATSPTYLFTKESITNLLKLPF
                     LELYADYYSTVKEHKVTTLHKEEIGYFFLDLLLKHYKENKEVAFYAEKLHVSSKYLTEA
                     LTLVSGKSPKEWIIHYTLQEIYALLENPSISIQEIVQRTRFANLATLRRFFKRHTGTSL
                     LQYRKQDLYKNNQ"
     CDS             complement(7865..8041)
                     /locus_tag="ctg169_9"
                     /transl_table=11
                     /translation="MELPDDPMMLFSMVNMKLRDCYHSLDELCDDMNVDKELLVKKLKA
                     AGFEYSKENNKFW"
     CDS             complement(8156..10435)
                     /locus_tag="ctg169_10"
                     /transl_table=11
                     /translation="MLRDYQIEMKTRLMEAWKAHRSVMVQMPTGTGKTHLLASVVSEFV
                     SSAGSGVWLIAHRRELVAQMEETLAKYGIRREDTPVRVMSVQWLSRHWNEAGDAPGLIV
                     IDEAHHALAASYTEMWKRYPAAKKLGVTATPCRLNRRGFTELFEVLVTSWSIAEFIEKG
                     VLSVFDYVSIRPGSEEQRLIDGLEKRGADGDYQVKEMDAVLNRRPGIERLYRSVRQFAS
                     GKKGMVYAISIEHARRIAEYYSRRGVNAVAVDSKTPAMERKRMVEEFRHGKIEVLVNVD
                     VFSEGFDCPDVEFVQLARPTLSLAKYLQQVGRGLRRSEGKEACMLIDNVGLYRIFGLPT
                     QRWNWDAMFRGRMAGKGSLPGRMNCDASVTAFPVVERPAEAGGDLVVVMEHGRLLSSIR
                     EQALPDEKERSPSCRLRAFVDKETGLWGLEKGDEMLPDASFKEILSIKGRFAVGRLRNG
                     CVRVLDDTGALVAEPGHCREVRFLKDDLLQVRHAGNSVSYVDLRNGRCYSVRPRVLRYG
                     SIELLQANRTYYSRTRQVYANTCGLPSSSIVWMGFYVKMYDGRVPSRCRRMEDGGFCCE
                     PQVCLLEGDEERAYYLSGWLPDQSIVVMDEEGRYYHVEKGHGKRYVACNRPSDRSEDFD
                     EAVALLRRQADERVEKHLQEEKCETERKRQRIISRSVEAVPFQIGVKWGLRTAERILIP
                     PVYRRILHPVGGYCAYQDSSCQWGVLAVDGRIIIRAQYMEVEIDRDGTARLTLVPGKME
                     TVKLTD"
     CDS             complement(10491..10940)
                     /locus_tag="ctg169_11"
                     /transl_table=11
                     /translation="MMINIYGGNNLIAPVASSAIQNFYGDRGDEAADQPEDSEKTENTE
                     SVADEKPAQEPAELSDDEFYVSVYIPDIKVMRAYKILLGECTTARELAVVVGKMLADEN
                     CRNVDKHTVVKAAFIKSLLPFAKRLVSGGTIANIRAQINNMLASK"
     CDS             11144..11713
                     /locus_tag="ctg169_12"
                     /transl_table=11
                     /translation="MKEYIMSFFNAPVTNKIPTCICSVAGLHTYISTNPQLEELTRKVR
                     AGLGDKQVFRKNKQTLLPYVTPAGIFSYCKEQCMQVPSGLFVIDIDELASTEEAAMWRD
                     RLFADEVLHPVLSFVSPGNQGVKLFIPYRINPFLSVEESFDNALHTAWEYLEWKYELKV
                     DRANADLSRACFLSHDGEAKINNHKY"
     CDS             11717..13660
                     /locus_tag="ctg169_13"
                     /transl_table=11
                     /translation="MNDSISILEQLVTAIEQAGVNVAPTYQEYMPLAFAIANTCGEEGR
                     TRFHRICRISEKYHHDEADKLYGHALTKGTGRNSMGTVFHLAEVAGVKMDPKLANLQNL
                     QSLHTHTRARVSYNAHPDASDGTPPDAVFTDPASPLSDGVSKTILPARLPYFPDYRWPA
                     FLQGIIDYGNSPAQRDILLLGAATVLGSTLNKLVSFVYGRKHKYPCLQVFVTAPPASGK
                     GALTWVRRLAEPIHNALLDTYREKIKTYRMEKTKWDTLGKEKANTPEPEQPQLKMLLIA
                     GDNTGTGIQENLMDSGGVGLICETEADTVSTAIGGDHGHWSDLLRKCFDHDRLAYNRRT
                     NHEYRECNVTFLCVLLSGTPAQIKPLIPSAENGLFSRQLFYYMPAIEEWEDQFNEADTD
                     YDSRFLEWGAQWKEVLDAITASVSNINMKLTHEQKEIFNFHFARVFGRASAIHGNQMKS
                     AVTRIAINIFRIISIIALLRSLESLLPGGERSGEPQENIVRTLLNCPGLTPSAHIPQEN
                     IADGIVPQFNLSIRTDDFYAVLALVEPLYRHACHILSLLPAGTPTAPSANMTPETLFDC
                     LPLRFTRNEAIDKGEQVGVPAGSVDSLLKRMTERGQLVKVGRGEYEFNARMHTRTCVGV
                     RESASSASLQDS"
     CDS             13678..13902
                     /locus_tag="ctg169_14"
                     /transl_table=11
                     /translation="MKDFLYFPSMTKGSLALLYFPGSNPRIATRHLMRWINGCPPLMEE
                     LSATGYHTSQKVFTSRQVTLINRHLGSPG"
ORIGIN
        1 agacatacat acaacacctt ttcatctaaa atttatgtat ttttgtagcc ctatagaaaa
       61 gaacagacat acaaatgatg gaagaaacaa cctgcaaacc tgattattcg aattcgatgg
      121 cggaacatct gggtatccgg tttctaccct ccaccgagga tgcggtacat gccgaaatgc
      181 ctgtagacca tcgtacttca caaccctttg gtatgttgaa cggcggcgcg tcactggctc
      241 tggccgagat tgtggcaggg catggctcta cgtcgctatg ccgggaaggc gaatatgcct
      301 gcggagtaca agtaagtgga aatcatctgt cggccgtgcc cgtcggaggc aaagtattcg
      361 ccaccggcaa actgattcac cgcggcagat cctcgcatat atggaatata gatatcacca
      421 ctccacaagg acaactggtt tctactgttc gtgtcgttaa tttcatactg aaaaagaaat
      481 gaatctacca gatatacata cgcaaaaatt attggattgc ctgacacaca gccgcctcgg
      541 tttcgccctc taccggttac cttggacaga cgaatgctac ctggtattgc aaacctcggg
      601 cgatgtggaa caattagcgg acattcagga actgaatgga aagaaaggat ttgtcatggc
      661 tcctttccgg atatcggagg aacatccctt ggtacttatc cgtccggatg tcaccgcata
      721 cgactggagc gaaatcagcg aagcactgtc ttcactggaa tgtgcggatg ccctgctcac
      781 ctgcaaaagc cggcagagtg aactctcccc ttttgtttcc gaagaaacgg ataaagaaca
      841 atatacccgc gcattcgggc gtttcatcac tcccttacaa gagaagcggt tccagaaact
      901 ggttctgtca cgttcttccg ccagacatat cagagatgat ttttcaccac tcggcgcttt
      961 tgtccgggcc tgcaacaact atccgcgcat gatgatttac ctatgccaca cccccgcttc
     1021 cggaacctgg ctgggcagca caccggaaat cttattaagc ggacacggca aagaatggca
     1081 caccgtggcc ctggccggta ccatgccgat gcagaacgaa gtgatgccga cagactggga
     1141 caagaagaac cgggaagagc agggctatgt ggctgattac atccgccgga tcgccaaaag
     1201 attcggcaac aagatgacgg aaaaaggtcc ttataccgcc cgtgccggac aattggtaca
     1261 cctcaagacc gatttttatt tcttgttgaa aaatacagac catataggcg atttattgca
     1321 agaactccat cccactcccg ccgtctgcgg cctgcccaaa gaggaggctt tccggtttat
     1381 tccggacaat gaagggtacg accgcagtta ttattccgga ttcaccggct ggctggacac
     1441 agaggggcat accgatatct acgtcaatct gcgctgcatg gaaataaagc cgggtgaagc
     1501 catcctgtat gcaggaggag gaatactggc ttcctcggaa gtagaatcgg aatggatgga
     1561 aacgggagac aagatgaata cgatgcggag catccttcat cctgacttta taaataaata
     1621 aatggaaaca attaaagtag aagaataatg tattcagaca aaaagaacat acttcagttg
     1681 gtggcacttc tcaaagcgca cggtgtgcgg aaaatagtgc tttgtcccgg cagccgtaat
     1741 gctgccatcg tacatactct ggccaatata gaggacttca cttgttattc tgtaaccgat
     1801 gaacgcagtg ccggtttttt tgccatcggc ctatctttac aagggggagg ccctgccgca
     1861 gtatgctgca cttccggttc ggccctgctg aacctgcacc ctgccgtagc cgaagccttt
     1921 taccaacaag tacctctgat tgtcatttcc gccgaccgcc ccgctgcctg gataggacaa
     1981 atggacggac aaaccctgcc ccagccccat gtgttcggaa cgttagtcaa gatgtctgtc
     2041 aacctgcccg aagtacatac tgaggaagac gaatggtttt gcaaccgcct tatcaacgaa
     2101 gccatactgg aaaccaccca ccacggcaaa gggcctgtac atatcaatgt acccatttcc
     2161 gaacccattt accgcttcac cgccaaaaca cttcccgaag tacgtgtcat cacccgttat
     2221 cagggactga gcgtgtacga ccgtgactat aaggaactga tcgaacggct gaacaagtac
     2281 aacaagcgca tggttgtggt aggccagatg aatctgattt acctgttcga gaaaaaatat
     2341 gtgaaaccgc tttataaaca tttcgcctgg ctgacggaac atctgggcaa ccagaccatc
     2401 cccggcattc ctatcaagaa tttcgacgcc gccgtttatt ccatgacacc ggaacgccag
     2461 gaagacatgg cccccgaaat actgattacc tacggcggac acatcgtatc caaacaattg
     2521 aagaaatacc tgcgcaatca tcccccgcgc gaacactggc atgttgccgc cgacgggaag
     2581 atagccgatt tatacggttg cctgaccacc gtcatcgaga tggatccgtt tgagttcttg
     2641 gaaaaaatag ctttcctgct ggacaacaaa cctacccatt atccgctgat gtgggaaaac
     2701 tattgcaaaa ccattccgat gccggacctt gcttattccg aaatctccgt tatcggaaaa
     2761 ctcatccggg cactgcccga accctgtgcc ctgcatctgg caaacagctc caccgtgcgc
     2821 tatgcacagt tatttacagt tcctccccag gtggaaatct gttgcaaccg gggagtgaac
     2881 ggcatagaag gctccctgtc caccgccatc ggttatgccg ccgcttccag caagctgaat
     2941 ttcatcatca taggcgactt gagcttcttc tatgacatga acgcactgtg gaatcaaaat
     3001 tacggtgcca acatccgcat cctgttactg aataacgaag gaggagaaat attccacacc
     3061 ctgcctggaa tggacaaatc aagccgttcc agggagttta tcacagccga gcattacacc
     3121 accgccaaag gctgggcgga agaacgcggc tttatttaca tgaaagtgac cggagaagaa
     3181 gagctggaag aagcgatgca gccattcacc tcacccgaga cacggatgca acccatgctg
     3241 ctggaggtgt ttaccgacaa ggaaaaagac accaccctgt taagagaata ttatcacgga
     3301 cttaaaaata aaaatgaata atggaaacaa gagaatggaa aaccatcaaa gaatatcagg
     3361 atattctgtt tgacttttac aacggaatag cgaaaatcac catcaaccgt ccgcgttacc
     3421 gcaacgcgtt cacccccacc actacttcgg aaatcagcga cgccctgtat tactgccgcg
     3481 agtgccagga tatcaatgta gtggttctga ccggagcagg cgacaaagcc ttctgcagcg
     3541 ggggagatat gcacgtaaag gggcatggcg gctatatcgg cacagatgga gttccccgtc
     3601 tgaatgtgct ggacgtacaa aagcaaatcc ggtcactgcc taaaccggtc atcgccatgg
     3661 taaacggtta cgccatcggc ggcggtcatg tgctgcatgt ggtatgcgat ctgaccattg
     3721 cctcagagaa tgccattttc ggacagacag gtcccaaggt aggcagcttc gacgccggat
     3781 tcggctcttc ctatctggca cgcatcgtag ggcagaagaa agcccgtgaa atatggttcc
     3841 tttgccgtca atactccgca caggaagcac tggaaatggg attggtcaat acagtcgttc
     3901 ctttctaccg cctggaagac gaaaccgtgg catgggcaga aaagatgatg gagcacagcc
     3961 cgctcgctct tcgtatgatc aaagccggac tgaatgccga actggacgga caagccggca
     4021 tacaagaact tgccggagat gccaccatgc tgtattacat gacagaggaa gcgcaggaag
     4081 gagggaaggc atttttggaa aaacgcaagc cacggttcca ggattatccg aagttcccat
     4141 aaacaaacta caaattcaaa gcatggacat tgaagaattc agaaaatatt gtctttcgtt
     4201 aggtgacgtt tccgaaaaga tgccatttgg caaatttgct gcaagatatg attccatcct
     4261 tgccttttat gtttatggac acatgttctg ttttatagac attgacaatt tcacttttgt
     4321 caatgtcaaa tctacttcgg acgaaattga gtatataaaa gagagacatg tttcagtcgg
     4381 caatcccatc aaccaaagtc tgaaacattg gcttcaactt aattttgatg gtgatattcc
     4441 cgacacgagc atatacacat gggtccaacg cgcctttgag attgtcaggg ataaatatac
     4501 caaaccaact acacataaaa aaaaatgttc caaacccaaa ttataaaaaa acaattacac
     4561 ttcaagcaac ctgccggtac ttccagagga gtatatacta cccgggatgt atggtacatc
     4621 ctcctcaccg acaccggcag ccgccactat ggcgtgggtg aatgtgcccc tctccctgcc
     4681 ctgagttgtg acgatatccc ctcatacgac gaggtgttgg ccactgcctg caagaacctg
     4741 gaaaagaacg gggaaataga ccgggaagcc ttgcttccct atccgtccat cctgttcggt
     4801 atggaaaccg ccctgctgca tttccgggca cgcagcctgc aattctggca caccccgttc
     4861 agcaaaggca aagagggtat ccccatcaac ggactcatct ggatgggaaa ctttgacgag
     4921 atgtaccggc gcatcgggga aaagatgcag caaggcttcc gctgcatcaa actcaaaata
     4981 ggcgccatcg actttgaaaa ggaactggag ctgctggcgc acatccgccg gcatttcacc
     5041 ccagcccaaa tcgaactgcg tgtagatgcc aacggtgctt tctctcctgc cgatgccctc
     5101 gaaaagttac atcgtctttc cgaattccag ctccattcca tcgaacagcc catccgtgcg
     5161 ggacaatggg atgaaatggc ccgactctgt gccgccaccc cctttcccat tgcactggat
     5221 gaagagctga taggcatcaa ccggcgcgac cggaaaatag aattgctgga aaccatccgt
     5281 cctcagtaca ttatcctgaa accttctctg cacggaggaa tcagcggctc cgaagaatgg
     5341 atggaactgg cggctgaaag aggcatcggc tcatgggtca cttccgctct ggagtccaat
     5401 atcggactga atgccatcgc acaatggtgt gccaccttgc agcccgccct cccccaagga
     5461 ctaggtaccg gcttgctgtt taccgacaat atagactatc cgcttcacat cgaaggggac
     5521 tgcctttggt tccaccccga agaacaagaa cccgatttac taaactggct gaaacaatga
     5581 caaaattctg caccaataga aacaaacaga ccattctgat agaaagcatc ccctactcca
     5641 actgggaaat tgaaatggta agaatgaata tccctgccga caaccgaagc ttccggcagg
     5701 aacttttctc ctttctttcc gaatggtttg acccggcaga caccctgccg gtacatactt
     5761 caggctccac cggcaaaccc aaggaactgt atgtagaaaa agaacgcatg atggaaagcg
     5821 cctgcctcac ctgttccttc ctcggactac aaaaagaaga ttccgccctg ctctgtatgc
     5881 ccttgcaata cattgccgga aaaatggtgg tagtacgtgc cttggtagcg ggactggact
     5941 tgctgcctgt cactccatcc gggcatcctt taaaagacct gacaaaagca cccgtctttg
     6001 ccgccatgat ccccatgcaa gtctataact cactgcaagt tcccgaagag aaagcgatat
     6061 tgcaacaaat cagacacctc attatcggag gcggtcctat cgactcccaa ctgaacgctg
     6121 cgttaaaaga tttcccccat gccgtatggt ctacctacgg catgaccgaa accttgtcac
     6181 acattgccct acgcagactg aacggtcctg aagcttcaga ctggtacacc cctttcgaga
     6241 gcatacagat ccgtctgagt aaagaaaaca ccttggtgat atacgctccc gaaatttgcg
     6301 aaaaagaact ggtgaccaat gacatagccg agataaacgg acagaaccaa ttccgcattc
     6361 taggcagaaa agacaacacg atcaatacag gaggagtaaa agtgcagata gaacaagtag
     6421 aggccgcatt gaaagaacac ctgtccgttc ctttcctgat cacctccgcc cccgacgaaa
     6481 aattcggaga aatcattgta ctgcttgccg aaggacaact gcccgacgac atagaacaga
     6541 cctgcacaca tcaattacct ccctactggc gtcccaaacg ttttgttccg gtattcaaac
     6601 ttcccctgac agaaaccggg aaacccgacc gtgccatagc caaattactg gcgcaaaaat
     6661 aactccgatc cattcataaa gggtgaattc aaaaaccaat caaacggtct ttttgaattc
     6721 acccttcttt ctgtaaaaaa gaataatttt ccgtgttctc ctacaactta cggaaagctc
     6781 aaattgtttt cctatcagta tattaaaaaa atcaaataca cgtagttttt ttccgtttta
     6841 ttttccctta tgtccactac tcccggtgga atgtatcatt aaattctaat tttgtgaagc
     6901 tagatttgat acaaagtatg ttatataata acccaaaacc acaggatacc aaagaaggac
     6961 tgtccgacca agatttcagt atttatatgg atgcgcacac agtgcctttc agcaaatacc
     7021 cctcttatat gccggcagga gttttgggta tatgtaccga aggaaatgcc gagatccagg
     7081 ttggcctccg gaaatatgtt atttgcgcaa acgacattct tattttcatg ccgggattcc
     7141 tggtttcatt tataaaatcc agcccgactt tcaccatcga ctattgtact ttttcaaatg
     7201 tcctttttta tgacgtgatc aatggaagta tcaaacgttt tccgaccggt tttcatacct
     7261 acacccagac ccactgcgtc tattcgctat cccaagagaa agcggaactg ttctccatct
     7321 atttccggtt attatacaac agagccactt cgccaactta tttatttaca aaagaatcta
     7381 ttaccaatct gctgaaatta ccttttctgg aactttatgc agactattac agcacggtaa
     7441 aagaacataa agtcaccacc ttgcataaag aagaaatcgg atactttttt ctggatttgc
     7501 tgttaaagca ttacaaagaa aacaaagaag tggcgttcta tgccgaaaag ttgcatgttt
     7561 cctccaaata cctgactgaa gccttgaccc tggtaagcgg aaaatccccc aaagaatgga
     7621 ttatacatta taccctgcaa gagatttacg cactattgga gaatccatcc atcagcatac
     7681 aggaaatcgt tcaaagaacc cggtttgcca atcttgccac cttaagacgt ttcttcaagc
     7741 ggcataccgg aacatccctg ttgcaatacc ggaaacagga cttatacaaa aataatcaat
     7801 aggtacctca ataaaaaaat cagcccgttc cacacattct tccggaacgg gctgatccct
     7861 ctatctacca aaacttgttg ttttccttac tatactcaaa tccggccgcc ttcaattttt
     7921 tcaccaacag ctccttgtct acattcatat catcacaaag ctcgtccagc gaatgatagc
     7981 agtcacgaag tttcatattc accatgctga aaagcatcat cgggtcatca ggtaattcca
     8041 tatcaatatc tcctttttaa aaatcggatg caaagttaca aaacttttca taatgatacg
     8101 tattccatcg ccaaatatcg gtttgacaaa aagttatccc ctgcttttta tcctatcagt
     8161 ccgtcagctt caccgtttcc atcttccccg gaaccaaagt aagacgcgcc gttccatccc
     8221 tgtctatctc cacttccata tactgggccc ggataatgat ccttccgtct acagccagta
     8281 ccccccactg gcaggagctg tcctgatagg cgcaataacc acccaccgga tgcaatatcc
     8341 tccgatagac aggtggaatc aaaatccgct ccgctgtcct cagcccccat ttcactccta
     8401 tttgaaaagg tacggcctcc acactcctgc tgattatacg ctgccgtttc cgttcagtct
     8461 cgcacttttc ctcctgcaaa tgtttctcca cacgctcgtc cgcctgcctt cggagcaatg
     8521 ccaccgcctc atcaaaatcc tcactccggt ccgacggacg gttacaggcc acataacgct
     8581 ttccatgccc tttctccaca tgataatacc gtccctcctc atccatcacc acaatacttt
     8641 gatccggcaa ccatccgctc aggtaataag cacgctcctc atccccctcc aacagacaaa
     8701 cctgcggttc acaacaaaag cctccatctt ccatgcggcg gcatcgagaa ggcactctgc
     8761 catcgtacat cttcacataa aaccccatcc acacgatgga cgaagaaggc aacccgcatg
     8821 tattggcata cacctgcctt gtcctgctgt aataagtacg gttcgcctgt aacaattcta
     8881 tgctcccgta tctgaggaca cgcgggcgga cagaataaca ccggccgttc cgtaaatcca
     8941 cataagacac cgaattcccg gcatgacgga cttgcaacaa atcatctttc agaaacctca
     9001 cctcacggca atgccccggt tcggccacca aagcccccgt atcatccagt acccggacac
     9061 acccgttccg aagcctcccc acggcaaaac gtcctttgat actcaaaatc tctttaaacg
     9121 aagcgtccgg cagcatctca tctccctttt ccaatcccca aagacctgtt tccttatcta
     9181 caaatgccct cagcctgcat gacggtgacc gctccttctc atccggcaaa gcctgctctc
     9241 tgatggaaga aagcaaacgc ccgtgctcca taaccaccac caagtcccca ccggcttcag
     9301 ccggcctttc caccaccgga aaagcggtaa cggaagcatc acagttcatc cgtccgggca
     9361 aactcccctt tcccgccatc cgtccccgga acatagcatc ccagttccat cgctgtgtag
     9421 gaagcccgaa aatgcggtac agccccacat tgtctatcag catacacgcc tccttgccct
     9481 ccgatctccg caatccgcgc cctacctgct gcaaatattt agccagtgac aaagtaggac
     9541 gggccagttg tacaaactcc acatcgggac agtcgaaccc ctcgctgaat acatccacat
     9601 tcaccagcac ctcgattttt ccatgtctga actcctccac catccgctta cgctccatag
     9661 caggagtctt gctgtccaca gccaccgcat tcactccccg cctgctgtaa tactccgcta
     9721 tccgccgggc atgttcaatg ctgatggcat acaccatccc cttcttgccg gaagcaaact
     9781 gcctgacact gcggtacagg cgctcgatac cgggacgcct gttcagtacc gcatccatct
     9841 ctttcacctg ataatcccca tcggcccccc gtttctccag accgtcaatg agccgctgct
     9901 cctcgctgcc gggacggatg gatacataat cgaacacaga caacacgcct ttttcaataa
     9961 actcggcaat actccacgaa gtaaccagta cctcgaacag ttccgtaaac cccctacggt
    10021 tcaggcggca aggtgtggca gtcacaccca gtttctttgc ggcaggataa cgcttccaca
    10081 tctccgtgta agaagcggcc aaggcatgat gagcctcgtc tatcacaatc agtcccggag
    10141 catcacccgc ctcattccag tgccgggaca gccattggac agacatcacc ctgaccggag
    10201 tatcctccct ccggatacca tatttagcca gcgtttcctc catttgcgcc accagttccc
    10261 tacgatgggc aataagccat accccgctgc cggcagaaga cacgaactca ctgaccacag
    10321 atgccagcaa atgtgtcttg cccgtaccgg taggcatctg caccatcaca ctccggtgag
    10381 ctttccacgc ttccatcaga cgtgttttca tctctatctg ataatcccgc aacataaata
    10441 atttgccgat ttgctaacgt gccaatggag taagaggata actgaaaaaa ttatttacta
    10501 gccagcatat tattaatctg cgcccgtata ttggctatcg taccgcccga cacaagccgt
    10561 ttggcaaaag gtagcaacga cttgatgaaa gccgctttca ccaccgtgtg tttgtctaca
    10621 ttcctacagt tctcatcggc cagcatcttt cctaccacca ccgccagttc gcgtgccgtg
    10681 gtacactctc ccaaaagtat cttgtaagcc ctcatcacct ttatatcggg tatatagacc
    10741 gatacgtaaa attcatcatc cgacagttcc gccggttcct gtgccggctt ctcatccgcc
    10801 acactttctg tattctccgt tttctcagaa tcttccggtt ggtcggcggc ctcatcaccc
    10861 cggtcgccat aaaagttctg aatggcggaa gacgccacag gggcaatcag attgtttccg
    10921 ccataaatat ttatcatcat atcaggtttt tcattcatat actatttctt ttctctattc
    10981 tttaattatt atcaacagat cgttaatcaa aatccatatt ttatcaatat ataatcaata
    11041 gcatgcacca atagtaaaca gatagtaaac ggttatgaat cgatttccat acgtcattcc
    11101 ctacccgtat atttgtgcag ataaatcaaa atcaatttct tttatgaaag aatacatcat
    11161 gtcatttttc aatgcacccg tcaccaataa aatacccaca tgtatatgca gtgtggcagg
    11221 gcttcatacc tacatcagca ccaatccgca actggaagaa ctgacgcgta aagtcagagc
    11281 cggactcgga gacaagcaag tgttccgaaa gaataaacag acccttttac cgtatgtcac
    11341 tccggcaggt atcttctctt actgcaaaga gcaatgcatg caagttcctt cgggcctctt
    11401 tgtcatagat attgacgaac tggcttccac cgaagaagcg gcaatgtggc gcgaccgcct
    11461 ctttgccgat gaagtgctgc accccgtact ttcctttgtc agccccggaa accagggagt
    11521 aaaactgttt atcccttacc gcataaaccc tttcctgagc gtggaagaat ccttcgacaa
    11581 tgccctgcac accgcatggg agtatctgga atggaaatac gagctgaaag tggacagggc
    11641 caatgccgac ttgtccagag cctgttttct gtcgcacgac ggagaagcga aaatcaataa
    11701 ccataaatat taaaaaatga acgattctat ttctatcttg gaacagctgg taacagccat
    11761 cgaacaagcg ggagtcaatg tggcccccac ctatcaggaa tatatgccgc tggcctttgc
    11821 catagccaac acttgcggcg aggaaggacg cacccggttc caccgcatct gccgcatatc
    11881 cgaaaagtac caccacgatg aagcagacaa actgtacgga catgccctga ccaaaggaac
    11941 aggcagaaat tccatgggaa ccgtcttcca tctggcagag gtggccgggg tgaaaatgga
    12001 cccgaaactt gcaaacttgc agaacttgca gtctctccac acccacacac gtgcgcgcgt
    12061 atcctataat gcccatccgg atgcttccga cgggactccg cccgatgccg ttttcacgga
    12121 cccagcctcc cccctgtccg acggcgtgtc caagaccatc ctccctgccc gacttcccta
    12181 tttccccgac taccgctggc ccgccttcct gcaaggaatc atagactacg gtaactctcc
    12241 cgcccaacgg gatatcctgc tgctgggtgc ggcaaccgtg ctgggaagca ccctcaacaa
    12301 actggtaagt tttgtgtacg gacgaaagca caagtatccc tgtctgcaag tattcgtcac
    12361 cgcgcctccc gcttccggca aaggtgcgct gacctgggta cgccgtttgg cagaacccat
    12421 acacaacgcg ctgctggaca cctaccggga aaaaataaag acctaccgca tggaaaagac
    12481 caaatgggac actttgggga aggaaaaggc aaataccccc gaacccgaac agccccagct
    12541 gaaaatgctc ctcatagccg gcgacaatac cggtacaggc atacaggaaa acctgatgga
    12601 ctccggaggc gtaggactga tatgcgaaac cgaggccgac accgtgagca ccgccattgg
    12661 aggcgaccac ggacactgga gcgacctcct ccggaaatgt ttcgaccatg accggctggc
    12721 ctacaaccgg cgcaccaatc acgaataccg cgaatgtaac gtcacgttcc tctgcgtact
    12781 tctcagcggc acgcctgcac aaatcaagcc ccttatccca tcggccgaaa acggattgtt
    12841 ctctcgccag ctgttctact atatgcctgc cattgaagaa tgggaagacc agttcaacga
    12901 agcggataca gactatgact cccgtttcct ggaatggggg gcacaatgga aagaagtgct
    12961 ggacgccatc accgcttcgg tgagcaacat caacatgaag ctcacccacg agcaaaaaga
    13021 gatattcaac ttccactttg cccgcgtatt cggacgagcc tccgccattc acggcaacca
    13081 gatgaaaagc gccgtaaccc gtattgccat caatatcttc cgcatcataa gcattatcgc
    13141 cctgctgcgc tctctggaat ccctgctgcc gggaggcgaa aggagcggcg aaccacagga
    13201 aaacatcgtg cgtaccctgc tgaactgtcc cggactgacc ccgtcggccc atattccaca
    13261 agaaaacata gcagacggaa tcgtaccgca attcaacctc tccatccgca ccgacgactt
    13321 ttatgccgtg ctggccctgg tggaacctct gtaccgccat gcatgccaca ttctctcgct
    13381 cctgcccgca ggaaccccca ccgcaccatc ggcgaacatg actcccgaaa ccctgttcga
    13441 ctgccttccc ctgcgcttca cccgcaacga agccatcgac aaaggagaac aggtaggagt
    13501 tccggcaggc tcggtggact cgctgctgaa acgtatgacc gaacgcggac agctggtcaa
    13561 agtggggcgt ggcgaatacg aattcaacgc gcgcatgcac acacgtacgt gtgtgggtgt
    13621 gagagagagt gcaagttctg caagtttgca agattcctga atttaaaatg tataaatatg
    13681 aaagatttcc tttatttccc atccatgaca aaaggtagcc tggctctgct ctattttccc
    13741 ggttcaaatc cccggatagc cacccggcat ctgatgaggt ggataaacgg ctgtccccct
    13801 ttgatggaag agttatccgc aacgggttac catacctcgc aaaaagtctt cacgagccgc
    13861 caggtgacac tgatcaaccg gcatctgggc agccccggat agccctgcaa gctctttgga
    13921 acaggatgaa agccataaag tgccacaagg tgtcataaag cgtcagcacg catttcacag
    13981 tacctatctt tgcaatgtca acaatgaggg agccgatacg ttactaacct tcggcctagc
    14041 atgttactaa catgtaaccc catacgttac taaccttcag ccttacacgt tacctacgtg
    14101 caatccgcaa gaaaagtaaa gtattctcct tcttcactga cg
//
