LOCUS       c00236_gnlPro..        11460 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HKHAAPHC_236.
ACCESSION   c00236_gnlPro..
VERSION     c00236_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 11:18:40
            Original ID  :: gnl|Prokka|HKHAAPHC_236
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11460
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11460
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1864:6573]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1865..6573
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..11460
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11460
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(184..1671)
                     /locus_tag="ctg236_1"
                     /transl_table=11
                     /translation="MKKNILLAVCFLMPLATMAQNDTLGHERNITLSEAIVLARTQSVD
                     AAVALNELKTAYWEYRTFRADLLPEVNFTGTLPNYNKSYSTYQNSDGSYSFVRNNTLGL
                     SGQLSVDQNIWFTGGKLSLTSSLDYLKQLGSGGAKQFMSVPVSLELTQPVFGVNTLKWN
                     RRIEPVRYAEAKAEFISATEEVTMKTITYFFELLLAKESLATAMQNKTNADRLYEVAIA
                     KRKMGQISENDLLQLKLNSLQGKADVTEAESNLNAKMFQLRSFLGVSEQESLNPVLPAT
                     VPDIKMEYDRVLNKALERNSFAQNIRRRQLEADYEVATARGNLRSIDLFASVGYTGQNH
                     EFSSAYRDLLDNQIVQVGVKIPILDWGKRRGKVRVAKSNREVVLSRIRQEQMDFNQDIF
                     LLVANFNNQAQQLDIAEEADVIAEKRYKTSVETFMIGKISTLDLNDAQNSKDEARQKHI
                     SELYYYWYYFYQLRSLTLWDFERDTELEADFEEVVRG"
     CDS             1865..2377
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg236_2"
                     /sec_met_domain="Glyoxalase_4 (E-value: 3.2e-26, bitscore:
                     81.2, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNFFIKEEFSFFVLLYTFIKKDTILTLIYIVMKISHIEHLGIAV
                     KSIEEALPYYENVLGLKCYNIETVEDQKVRTAFLKVGDVKIELLEPTSPESTIAKFIEK
                     NNGNGGMHHLAFAVEDGVAGALAEVEEKGIRLIDKAPRKGAEGLNIAFLHPKSTLGVLT
                     ELCEKPE"
     CDS             2436..3989
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg236_3"
                     /sec_met_domain="CT_Btheta (E-value: 1e-291, bitscore:
                     956.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIDRRAAARLGGGEKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAQTEEEGLALIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDNPN
                     KPYDMYEVIGAIIDNGEFLEIQKDYSKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             4021..4953
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg236_4"
                     /sec_met_domain="OAD_gamma (E-value: 8.4e-18, bitscore:
                     54.3, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLMLVLGFCSSCKEQKSNNKLLLNEVLVNNESNYQ
                     DDYGVHSAWIEIFNRSYGSADLAGCYLKFSSQPGDTASYFIPKGDVLTLVKPRQHALFW
                     ADGEPRRGTFHTNFKLDATNANWIGLYDSGKKLLDQVIVPAGTLKANQSYARVSDAADQ
                     WEVKGGSEDKYVTPSTNNKTIDSNAKMEKFEEHDSVGIGMAISAMSVVFCGLILLYISF
                     KIIGKISVNLSKRNAMKAKGITDKQEAKEKQLGQAPGEVFAAISMAMHEFQSDVHDVED
                     TILTITRVKRSYSPWSSKIYTLRETPHKK"
     CDS             4977..5411
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.3; E-value:
                     2.7e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg236_5"
                     /sec_met_domain="Biotin_lipoyl (E-value: 4.4e-22, bitscore:
                     67.3, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNVYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKVV
                     VKPVARPAATSAPAAPATPVVKPAAASTGKSGVKSPLPGVILDIKVNVGDTVKKGQVII
                     ILEAMKMENNINADKDGKITAINVNKGDSVLEGTDLVIIE"
     CDS             5413..6573
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg236_6"
                     /sec_met_domain="OAD_beta (E-value: 3.9e-153, bitscore:
                     498.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFITFLGNNLADFWTYTGFANATVGHVVMLLVGLFFIYLAVAK
                     EFEPMLLIPIGFGMLIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLVGAAAQFGIFGAYMIALAIGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRWLTSKNERLIRMKPPRVVSHTEKVMFP
                     IIGLLLTTFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFGLGALSFVIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             6743..7792
                     /locus_tag="ctg236_7"
                     /transl_table=11
                     /translation="MRKLFISLCFSACCSLLAAQTTNPIQEAMANYDYETALMLIDQET
                     PTVPLLYQKGKALKGLGNNLEALSVFQEVVAQDSLNPRAYIEAAECCKSLAKYSEALDY
                     YQNALHINPDNKYARIQYISLLMNMKRYRESLKESNLLAERDSSAYVLHLRAESMGQVY
                     DNTEIMHVIDAYLDIQKRYPNDYLSAAKLGNIYVAGHQYEDAINITEKYRSIDSTNVLV
                     NRINAQAYCLNKDYPKAIERYEQLLQEKDSSFQTCFYAGISYYALEDFYPAHDLLERAL
                     KDDNTNINVLYYLGRACSKTSWKEDGVTYLETAVSLAMPSDSVIPAYMWGLRTATRWHF
                     NTPTRRIPF"
     CDS             7753..8094
                     /locus_tag="ctg236_8"
                     /transl_table=11
                     /translation="MAFQYTDQANTLLTQYEKYDRQKHKLLYDAAFIYYYYLKDVSKAE
                     RYLTAYLKTRPKNSKDKVQEVDADGVPIIGEDNRYNAAENWLKDIREKRKKEDFFKGKV
                     DTASVTPIK"
     CDS             8205..10055
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg236_9"
                     /sec_met_domain="Alpha-amylase (E-value: 1.7e-64, bitscore:
                     207.8, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVFLILGTLLLSLSTYAAMNVNKIDPPFWYTGMQNPELQLMVY
                     GEGIGNAAVSVNYPGVSLSSTVKLESNNYLLVYLKLDKDVKPGKFNLTFTEGKKKLVKE
                     YELKARNKKGCEHKGFDASDALYLLMPDRFANGNPDNDQIAGMAEYKIDRKDPNARHGG
                     DLAGIEQHLDYFSDLGVTALWFTPVLENNMTGGSYHGYATTDYYKVDPRFGTNEEYKQL
                     IEKAHARGIKIVMDMIFNHCGVEHVWIKDMPSKDWFNNPDHENNFVQTSFKLTPHVDPY
                     TSQYDADQMNDGWFVPSMPDLNQKNPHVYRYLVQNSFWWIEFANIDGIRMDTYPYADYD
                     AMSNWMKELNEEYPNYNTVGETWVTEPAYTAWWQKDSKLSAPKNSNLKTVMDFSFFDKI
                     NTAKNEQTETWFKGLDRIYNNFVYDFLYPNPASVLAFIENHDTDRFLGEGNNLPMLKQA
                     STLLLTTRRIPQLYYGTEVMMNGVKSKSDGYVRKDFPGGWTGDATNALTPAGRTKIQNE
                     CYDFYKTILNWRKGNDVIAKGSMVQFMVQNGVYAYARQYEGKTIFVMLNGTDAETTVPL
                     KFYKEILKDSKQGKDILSGKAITFGEELKMGPRESLVIEL"
     CDS             complement(10526..11458)
                     /locus_tag="ctg236_10"
                     /transl_table=11
                     /translation="PAFNFNNMEQMQAIIKAAVETKSPVILQVSKGARQYANATLLRYM
                     AQGAVEYAKELGCKHPEIVLHLDHGDTFETCKSCIDSGFSSVMIDGSHLPYEENVALTK
                     KVVDYAHQFDVTVEGELGVLAGVEDEVSAEHHTYTNPEEVIDFATRTGCDSLAISIGTS
                     HGAYKFKPEQCHVDPATGRLVPPPLEFAVLDAVMEKLPGFPIVLHGSSSVPQEEVDTIN
                     KYGGKLEAAIGIPEEQLRKAAKSAVCKINIDSDSRLAMTAAIRKTFAEKPAEFDPRKYL
                     GPARDNMEKLYKHKIINVLGSENKLAQLD"
ORIGIN
        1 caagagcaat taacctacgc tcatttccaa taaattacac tcttttcgta acttctttcc
       61 cgcaaaaata agtaaaaaag cagagttatg aatgataagt tataagttat ttacctataa
      121 tatcgcatat acggtacttt taccggcaaa taactcataa cttatcactt gcaacccgtc
      181 gacttatcct cttaccacct cttcaaaatc agcttccaat tccgtatcgc gttcaaaatc
      241 ccaaagggtc aagctgcgga gctgatagaa gtaataccaa tagtagtaca gctctgaaat
      301 atgcttttga cgggcttcgt ctttagagtt ctgtgcatcg ttcaggtcca gggtgctgat
      361 tttacctatc ataaaggtct ctacactggt cttgtaacgc ttctcagcaa tgacatccgc
      421 ctcttcggct atgtccagct gttgcgcctg gttgttgaag ttagccacca gtaaaaagat
      481 gtcctggtta aagtccatct gttcctgacg gattctggac aagaccactt cacggttgct
      541 ctttgccacc cttaccttac cacggcgctt gccccagtca aggataggaa tcttgacgcc
      601 cacctgcaca atctgattgt caagcaaatc ccggtaggct gaagagaatt catggttctg
      661 ccccgtatag cccacactgg caaagaggtc gatgctgcgc aggtttccgc gtgccgttgc
      721 cacttcataa tcagcttcga gctggcggcg gcgaatgttc tgtgcaaagg agttgcgttc
      781 cagtgccttg ttcagcacac ggtcatactc catctttata tcgggaacag tggcgggcaa
      841 caccggattc aggctttcct gctcggacac cccgaggaaa gaacggagct ggaacatttt
      901 tgcattcagg ttgctctctg cctcagtcac gtcggccttg ccctgcaatg aattcagttt
      961 aagctgcaac aaatcattct cggatatctg tcccatttta cgtttggcta tggccacttc
     1021 ataaaggcgg tcggcattcg tcttgttctg catggcggta gcgagcgatt ctttggccag
     1081 cagcaactca aagaaataag tgatggtttt catcgtcacc tcttccgtag ctgaaatgaa
     1141 ctcggccttt gcctcagcat agcgtacggg ctctatacgg cggttccact tcaaggtatt
     1201 cactccgaag accggctgcg tcaactccag gctcacgggg actgacatga actgcttcgc
     1261 tcctccggaa cccagttgtt tgagataatc cagcgaagaa gtcagtgaca gcttaccccc
     1321 cgtaaaccaa atgttctggt ctaccgaaag ctggccggac agccccagtg tattgttgcg
     1381 gacaaagcta taggagccgt cggaattctg gtaggtactg taggacttgt tatagttggg
     1441 tagtgtaccg gtgaaattca cttccggcaa caagtccgca cggaatgtac ggtattccca
     1501 atacgcggtt ttcaattcat tcaatgccac agcagcatcc acagactgcg tacgggccag
     1561 tacaatggcc tccgacagcg taatattgcg ttcatgtccc aaagtatcat tctgcgccat
     1621 ggttgccaac ggcatcaaaa aacaaactgc aagtaaaata ttctttttca tgttcaatct
     1681 ttaaaattgt cgcaaacaga aaagcaaaga gtgtgccaag tggccgggaa gatttcatag
     1741 aggggtaagt gttcattttc ggacagtggg gatgtccgtt agcggacgat atcaggaaaa
     1801 caaccggtct ctatctaaag tctgaaaaaa tccttctaaa gttcaattat ccatgaatta
     1861 attgatgaaa aatttcttta ttaaggaaga attctctttc tttgtgctgc tttatacctt
     1921 tattaaaaag gatacaatac taacattaat ttatatagtt atgaagattt cacacattga
     1981 gcatctgggc attgccgtta agagcattga agaagccctt ccgtactacg aaaacgtttt
     2041 aggtttgaaa tgctacaaca tcgaaaccgt ggaagatcag aaagttagaa ccgctttcct
     2101 gaaagtgggc gatgtaaaga tcgaattgtt ggaacctact tctcccgaaa gcacaattgc
     2161 caagttcatc gaaaagaaca acggtaacgg tggcatgcat catctcgcat tcgccgttga
     2221 agacggagtg gccggtgcgc ttgccgaagt cgaagaaaaa ggtatccgcc ttatagacaa
     2281 agctccccgc aaaggtgcag aaggtctgaa cattgcattc ctgcatccga agtcaactct
     2341 cggtgtcctg accgagcttt gcgagaaacc ggaataagca agactgtaaa atcatcaaat
     2401 cataaattgt ataaacactt aaagaatata aattcatgag taatcaactt gaaaagatta
     2461 aagagcttat agaccgccgc gctgcagcac gtctcggtgg tggtgaaaaa gcgattgcaa
     2521 agcaacacga gaagggtaaa tatacagctc gcgagcgcat agccatgctt ctcgacgaag
     2581 gcagtttcga agaaatggac atgttcgtag aacatagatg caccaacttc ggcatggaaa
     2641 agaaacacta ccccggtgac ggtgtagtaa ccggttgcgg tacaatcgaa ggccgtctgg
     2701 tttatatctt cgcacaggac ttcacagttt ctgccggttc actgtccgaa accatgtctc
     2761 tgaaaatctg taagattatg gaccaagcca tgaaaatggg tgctccgtgt atcggtatca
     2821 acgactcggg cggtgcacgt attcaggaag gtattaatgc cttggctggc tacgctgaaa
     2881 tcttccaacg taacatcctt gcttccggtg tcatcccgca gatttccggt attttcggtc
     2941 cttgtgccgg tggtgccgtt tactctcctg cattgactga ctttactttg atgatggaag
     3001 gtacatccta catgttcctt accggtccga aggtagtaaa gactgtaacc ggagaagacg
     3061 taagccagga aaacctgggt ggcgcgagtg ttcactccac caaatctggt gttactcatt
     3121 ttactgcaca gacagaagaa gaaggtttgg cccttatccg caaactgttg agctacattc
     3181 cccagaacaa tctggaagaa gctccctatg tagactgtac agaccctatt gaccgtctgg
     3241 aagattccct gaacgatatc attcctgata acccgaacaa accgtacgat atgtacgagg
     3301 taattggcgc tatcatagat aatggtgagt tcctcgaaat ccaaaaagat tattcaaaga
     3361 atatcattat tggtttcgca cgtttcaacg gacagtccgt aggtattgtt gccaaccagc
     3421 cgaagtatct ggcaggtgtg ctcgacagca acgcatcccg caagggcgca cgcttcgtcc
     3481 gtttctgcga cgccttcaat attcctatcg tatcattggt agacgtaccg ggattccttc
     3541 cgggaaccgg ccaggagtac aacggcgtca tcctgcacgg tgccaaactg ctgtatgcat
     3601 acggtgaagc tactgtaccc aaggttacca tcacactgcg taaatcctac ggtggttcgc
     3661 acatcgtgat gagctgtaag cagctgcgtg gcgacatgaa ttatgcttgg cctactgctg
     3721 aaatcgctgt aatgggtggt gcaggtgccg tagaagtatt atatgcccgc gaagccaaag
     3781 agcaggaaaa tccggctcaa ttcctggctg aaaaagaggc tgaatacacc aagttgtttg
     3841 ccaatcctta taatgcagct aaatatggct acattgatga tgttatcgaa ccgcgtaaca
     3901 cacgtttccg catcattcgt gccctgcaac agttgcaaac caagaaattg actaacccgg
     3961 ctaagaaaca tggtaatatt cccttgtaat caagcttttc acactaaaac aagaacgatt
     4021 atgaataaaa caaaaatcgg aatattcctt tcattgatgc tggtgttagg cttttgctct
     4081 tcttgcaaag aacagaaatc gaacaacaaa ctgctgctga atgaagtgct ggtcaacaac
     4141 gaaagcaact atcaggatga ctacggtgtg cacagcgcat ggattgaaat attcaacaga
     4201 tcatacggca gcgccgacct tgcaggttgc tatctgaaat tcagcagcca gccgggtgat
     4261 actgccagtt atttcattcc caaaggtgac gttctgacac tcgtaaaacc acgtcagcat
     4321 gcacttttct gggctgatgg agaaccaaga cgcggtacat ttcatacgaa cttcaaactg
     4381 gatgccacaa atgccaactg gattgggttg tatgattccg gcaagaaatt gcttgatcaa
     4441 gtcatagtgc ctgccggtac tttaaaagcc aaccaatcct atgcccgtgt cagtgatgca
     4501 gccgaccaat gggaagtaaa gggtggaagc gaagataaat atgtcactcc gagtaccaac
     4561 aacaagacta tcgacagcaa tgccaaaatg gaaaaattcg aagagcatga cagcgtaggt
     4621 atcggtatgg ctatttctgc catgagcgtt gtattctgcg ggctgatatt actctacatc
     4681 tccttcaaga ttataggtaa aatatcagtt aacctcagca aacgcaatgc catgaaagct
     4741 aaaggtatta ctgataaaca agaagcaaaa gagaaacaac tggggcaggc tccgggagaa
     4801 gtttttgctg ccatttcaat ggccatgcac gaattccaaa gcgatgtaca cgatgtggaa
     4861 gacacgatac ttaccattac ccgtgtaaaa cgcagttact caccgtggag ttcaaagatt
     4921 tatacgttgc gtgagactcc tcacaaaaag taagtcaccc ataataaaat aaaacgatga
     4981 aagaatataa atataaaatt aacggtaacg tatataaagt tgccattgga gatattgaag
     5041 acaacatcgc tcatgtagaa gtgaacggta ctccctacaa agttgaaatg gaaaaagcac
     5101 cgaaggtagt cgttaaaccg gtagcacgtc cggcagccac atccgctcct gctgctcctg
     5161 ctactccggt agtaaaaccg gccgctgctt ctaccggcaa gtcaggtgta aaatctccgc
     5221 ttcccggtgt aatcctcgat atcaaagtaa atgtcggcga tacagtaaag aagggacaag
     5281 ttatcatcat tttggaagcc atgaagatgg aaaacaatat caatgctgat aaagacggta
     5341 agattacagc catcaatgta aacaaagggg actctgttct cgaaggtact gacctcgtaa
     5401 ttattgaata atatgggaga atttatcaca tttttaggaa acaaccttgc cgacttctgg
     5461 acttatacag gttttgccaa tgcaacggta ggacatgtgg taatgcttct ggtaggtttg
     5521 tttttcatat acttggctgt agccaaggaa tttgagccga tgctattaat tcctatcggt
     5581 ttcggtatgc tgattggtaa tatacctttc aatatggaag ccggattaaa agtcggtatc
     5641 tatgaagaag gttccgtact taatattctg taccagggag taacctccgg ttggtacccg
     5701 ccactcatat tcctgggtat cggtgccatg acggatttct ctgctttgat atcgaacccc
     5761 aaattaatgt tggttggtgc agcagcccaa ttcggtatat tcggtgctta tatgattgcc
     5821 cttgccatag gatttgaccc gatgcaggct ggtgcaatcg gtatcattgg tggtgccgat
     5881 ggtccgactg ccatcttcct ctcttccaaa ctggctccta acttaatggg tgccattgcg
     5941 gtatcagcct attcatatat ggcattagta ccggtgatac agccgcctat tatgcgttgg
     6001 ctgaccagta aaaatgaacg tcttatccgt atgaaacctc cccgtgtggt ttcacatacg
     6061 gaaaaagtaa tgttcccgat tatcggtttg ttactgacca cattccttgt accatccggt
     6121 ctgcctttgc tgggtatgct gttcttcggt aatttactga aagaaagtgg agtcacacgt
     6181 cgtctggcaa acacagccag tggtccgctg attgatacca ttactattct gcttggtttg
     6241 acagtaggtg cttctacgca agcatccgag ttcttaaccc ttgattcaat caagatattc
     6301 ggtctgggcg ccttatcatt tgtcattgcc acagcatccg gtgtcatctt cgtgaagatt
     6361 ttcaacctct tcctgaagaa aggcaacaag attaatccgt tgatcggtaa tgccggtgta
     6421 tctgccgtac ccgactctgc acgtatctcc caagtagtag gtctggaata cgatcctacc
     6481 aactatctgc tgatgcatgc catgggcccg aacgttgccg gtgtaatcgg ttccgctgta
     6541 gcagcaggta tcctgctggg attcttaatg taatacattt attcattccg ttatccggct
     6601 tgaattctga actattttag agccccttca tttttggagg ggctttttcg ttaatctatc
     6661 taaaacagat tacgattatt tcgtaaatac attcttttta gtaacttgca gtcagtttaa
     6721 cctcatataa atgatatact gtatgcgaaa gctttttatc tccttatgtt tcagtgcatg
     6781 ctgttcgctt ctggcggcac agaccacaaa ccccattcaa gaggcgatgg ccaactacga
     6841 ttatgaaaca gccttgatgc tgatcgatca agaaaccccg accgtccccc tactctacca
     6901 aaaagggaaa gcgctgaaag ggctgggcaa taaccttgaa gctctgagcg tatttcagga
     6961 agtcgtagct caggattctc tcaatccccg ggcatacatt gaagctgccg aatgctgcaa
     7021 atcactagcc aaatatagcg aggcgctgga ttactaccag aatgcgctcc acataaaccc
     7081 ggacaataaa tacgcacgca tccagtatat cagtctgctg atgaacatga agagataccg
     7141 tgagtctcta aaggaaagca acctgctggc agaaagggac agttccgcct atgtactaca
     7201 ccttagagcc gaaagtatgg ggcaagtcta tgacaacaca gaaatcatgc atgtgataga
     7261 tgcctacctg gacatacaga aaaggtatcc caatgattac ctgtctgctg ccaaactcgg
     7321 caacatctat gtagcaggcc atcagtatga agacgccata aacataacgg agaaataccg
     7381 ttccatagac tccaccaacg tccttgtgaa ccgcatcaat gcccaagcct attgcctgaa
     7441 caaagattac cccaaagcaa tagagagata tgaacaactg ttgcaggaaa aggacagctc
     7501 cttccaaacc tgcttctacg ccggaatcag ctattatgcc ctcgaagact tctacccagc
     7561 acacgacctg ctggaaaggg ctcttaaaga tgacaatacc aacatcaacg ttctctatta
     7621 tctgggacgc gcctgctcca agacatcatg gaaagaggat ggagtgactt atctggaaac
     7681 tgccgtaagc ctcgccatgc ccagcgacag tgtcattccc gcctatatgt ggggcttgcg
     7741 gactgctaca agatggcatt tcaatacacc gaccaggcga atacccttct gacgcaatac
     7801 gaaaaatacg accggcagaa acacaaactg ctctacgacg cagcctttat ctattattac
     7861 tatctgaaag atgtgtccaa agcagagaga tatctgacgg catacctgaa aacccgtccg
     7921 aaaaacagca aggacaaagt gcaggaagta gatgcggacg gagttcccat catcggagaa
     7981 gacaaccgat acaatgccgc cgaaaactgg ctgaaggaca tcagagaaaa gcgcaagaaa
     8041 gaggacttct tcaagggaaa ggtcgatacc gctagcgtaa cccccatcaa atagccccaa
     8101 tgaaaacgtt tgcataatat aataaggtac agtaacggag aaagattaac tttctccgtt
     8161 atttgtttta aattagcgca aaaattaacc gtaaagttac tatcatgaaa aaagtattct
     8221 taatcttggg aacactctta ctctccctca gtacgtatgc agctatgaat gtgaacaaaa
     8281 tcgaccctcc gttttggtac accggcatgc agaacccgga actccagctg atggtctatg
     8341 gcgaaggcat cggcaacgcg gcagtatccg tcaattatcc cggcgtctca ttgagcagca
     8401 ccgtcaagct ggaaagcaac aactacctcc tggtctatct gaaactggac aaggatgtaa
     8461 aacccggcaa attcaacctc accttcactg aaggaaaaaa gaaactcgta aaggaatatg
     8521 aactgaaggc acgcaacaag aaaggttgcg aacataaagg tttcgacgcc tccgacgcac
     8581 tgtacctgct gatgcccgac cgctttgcca atggcaaccc ggacaatgac cagattgcgg
     8641 gcatggccga gtacaagata gaccgcaaag accccaatgc acgccacggc ggtgaccttg
     8701 ccggcatcga acaacacctg gactacttct ccgacctcgg cgtcacagcc ctctggttta
     8761 ctccggtact ggaaaacaac atgaccggcg gttcctatca cggctatgcc accacagact
     8821 actacaaggt ggacccgcgc ttcggtacca acgaagaata caagcaactg attgaaaaag
     8881 cccatgcacg cggcatcaaa atcgtaatgg acatgatttt caaccactgc ggcgtagagc
     8941 atgtatggat taaggacatg ccctccaaag attggttcaa caaccccgac cacgaaaaca
     9001 acttcgtgca gacctccttc aaactgaccc cgcacgtaga cccttatact tcccagtacg
     9061 atgccgacca gatgaacgac ggctggtttg taccttccat gcccgacctc aaccagaaga
     9121 atcctcacgt ttaccgctac ctggtacaga acagtttctg gtggattgaa ttcgccaaca
     9181 tcgacggcat ccgcatggac acttacccgt atgccgacta tgatgccatg agcaactgga
     9241 tgaaagagct caacgaagaa tatcccaact acaacaccgt gggcgagacc tgggttaccg
     9301 aacccgccta caccgcctgg tggcagaagg attccaagct atcagccccc aagaacagta
     9361 acctcaagac cgttatggac ttcagcttct tcgacaagat aaacaccgcc aagaatgaac
     9421 agaccgaaac ttggttcaag ggactggacc gcatatacaa taacttcgta tacgacttcc
     9481 tctaccccaa ccccgcttcc gtactggcat tcatcgaaaa ccacgacacc gaccgcttcc
     9541 tgggcgaagg caacaacctt ccgatgctga agcaagcctc taccctgctg cttaccaccc
     9601 gccgcattcc gcaactctac tacggaacgg aagtcatgat gaatggcgtg aagagcaaga
     9661 gcgacggcta tgtccgcaag gacttccccg gcggatggac cggtgacgca acaaacgcac
     9721 tgaccccagc cggacgtacc aaaatacaga acgagtgcta cgacttctac aagaccatcc
     9781 taaactggcg caaaggaaac gatgtgattg ccaaaggcag catggtgcag ttcatggtac
     9841 agaatggtgt ttatgcctac gcacgccagt acgaaggcaa gacgatattc gtgatgctga
     9901 acggtacaga tgcagagacc accgttcctt tgaaattcta caaggaaatc ctaaaagaca
     9961 gcaagcaggg aaaagatatt cttagcggca aggccatcac cttcggtgaa gagctgaaga
    10021 tgggccccag agaatcatta gtgatagaat tataacgcgc actccacaca gagagctcat
    10081 tcttgcaaat ctcccttgca gatagcttgc agacacctcg cctgccagcc atctgcaagg
    10141 gatttttagt atggaatagg tgtcacgggg atatgctttt caccggtctc aaatatagct
    10201 aatctgttag ttcataacgg tgaacacttt gttccagtat agagaaacaa agtgttcgga
    10261 tatgtagaaa caaagtgttc ttacgtattg gaacgaagtg tttttgcata ttggaacgaa
    10321 gtgttctctt tattgaaaca aactgttcag ttaagggaaa cagactgttt tgttaaagga
    10381 aacagactgt tgtacacgtt gaaacatccg cttctgaaat aaccggcgaa cttaaccatc
    10441 ccacaacacc ggcctatata taacaagtca gcccttgcaa catcaatatt gcaagggctg
    10501 acgctatatt cggattatct ttcgattagt ccagttgagc caatttgttc tctgaaccaa
    10561 gcacgttgat gattttatgc ttgtacagtt tttccatatt gtcacgagcc ggacccagat
    10621 acttacgcgg gtcgaattct gccggttttt cagcaaatgt cttgcggata gcagctgtca
    10681 tagccagacg tgagtcagag tcgatgttga ttttgcaaac agcagacttg gcagccttac
    10741 gcaactgctc ttcggggata ccgatagcag cttccagctt accaccatac ttgttgatag
    10801 tatcaacttc ttcctgagga actgaagaag aaccgtgaag aacgatgggg aatcccggaa
    10861 gtttctccat tacagcatcc agaacggcaa attccaaagg aggaggaacc agacgaccgg
    10921 tagcagggtc aacgtggcat tgttcgggtt tgaacttgta tgcaccatga gaagtaccga
    10981 ttgagatagc cagtgaatcg caacctgtac gggtagcgaa gtcaataact tcttcaggat
    11041 tagtatatgt atggtgttct gcagaaactt catcttctac accggccaat acaccgagtt
    11101 cgccttctac agttacgtcg aactgatggg catagtcaac taccttctta gtcagtgcaa
    11161 cgttttcttc gtacggaagg tgtgaaccgt caatcattac tgaagagaaa ccggagtcga
    11221 tacagctctt gcaagtttcg aatgtatctc cgtggtcaag gtgaagaaca atttcaggat
    11281 gtttgcaacc caattcctta gcgtactcaa cagcaccctg agccatgtaa cgcaacagcg
    11341 tagcgttggc atactgacgg gcacccttag atacctgaag aataaccgga gactttgttt
    11401 caactgcagc cttgatgata gcctgcatct gttccatatt gttgaagttg aatgccggaa
//
