LOCUS       gnlProkkaDKKLBDJE_136  14099 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DKKLBDJE_136.
ACCESSION   gnlProkkaDKKLBDJE_136
VERSION     gnlProkkaDKKLBDJE_136
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 04:58:58
            Original ID  :: gnl|Prokka|DKKLBDJE_136
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14099
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14099
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3832:4099]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3833..4099
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14099
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14099
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             12..923
                     /locus_tag="ctg136_1"
                     /transl_table=11
                     /translation="MKPTLFLLAAGMGSRYGGLKQLDGLGPNGETIMDYSIYDAINAGF
                     GKLVFVIRKDFEQDFRDKIISKYEGHIPCELVFQSIDDLPEGFTCPEGRTKPWGTNHAV
                     MMGADVIKEPFAVINCDDFYGRDSFQVMGKFLAALPEGSKNVYSMVGFRIGNTLSESGT
                     VSRGLCGTDANNLLTSVVERTKIQRMDGEVKYIDDNGEWTATPETTPVSMNFWGFTPDY
                     FAYSAEFFKSFLSDPKNMENLKSEFFIPLMVDKLINDGTATCEVLDTTSKWFGVTYPED
                     RQSVVDKIQALVDAGEYPAKLF"
     CDS             complement(968..2638)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 277.7; E-value:
                     3.2e-84)"
                     /gene_kind="transport"
                     /locus_tag="ctg136_2"
                     /transl_table=11
                     /translation="MKKQQKDKKVKKDRREKLRYIREVSAEQRGRILLSCLTGILGVAF
                     ALAFIYATKRVIDTATGITDDNLTHIAVLTVVLLTAQLLCGAADTWISTRMQIETGNAL
                     RHRLFSRLLQSRWNELERFHTGDVVNRVEQDTTAIVTLLTSSVPAFIVTSIQLLAAFLF
                     FYFLDPSLPWLIVAILPVFLSGSRFYMRRMKRYTHDIRNSDGRIQSVIQESLQHRIVIK
                     TLEQGERHLDKLDDLQDMLHSQVMGRTRFSLSAHMLVALAFSGGYLTAFLWGAVHLSAG
                     CITFGTMTAFLQLVGKVQRPVFDLSRLIPSVVNALTAIDRLLELERLPAEADGDSIFLA
                     STPELELKDVTFRYTPDDRPVFSRFSCRFPAGSCIAIVGETGKGKTTLIRLLLALATPQ
                     EGQILLIPAKHPLETSHTVSPQTRKNFVYVPQGNTLFSGTIRDNLLMGNPQASQEAIYQ
                     ALQTATADFVFHLPDGVDSPLSERGGGLSEGQAQRIAIARALLRPGNILLLDEATSALD
                     PDTERLLIKNLRRDCAGKTCIFVTHHPAVAEACESIVRL"
     CDS             complement(2661..3824)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg136_3"
                     /sec_met_domain="NTP_transf_5 (E-value: 1.1e-45, bitscore:
                     148.0, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQHAFFSLVRSGLWGTPADRQLFRSVSPDDWETVYRMANSQALLA
                     LTFDGISSLPAELRPPRVLYLKWAARTAQIEQANKRLNQLLPELNTLYREAGLHPVLLK
                     GQGIGTNYRTPLHRQCGDIDIYLGKQGQPIANRLLLQQGAIVEGEASDKHASYSLKGVH
                     IENHRIILRLNSPLANRYFQQIIRKWYPQETDYALFSETGKEDSKAVSIAIPPATFNAL
                     YIFLHAFVHFLNSGIGLRQLCDWTCLLANRHKEIDATTLLRQLQDLGLLHAAQAFGYIA
                     VTRLGLPANRLPFPLEGTKQIGEQLLEDILSTGNFGQHDNRIKPRPKGYWAGKWYTFCR
                     ATRRCNELRQFAPYEALWYPVTLIGGTIAIQINRSKGVKDKKARTKK"
     CDS             complement(3833..4099)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg136_4"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 5.1e-13,
                     bitscore: 41.0, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.4e-15, bitscore: 48.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIKQGFILHRIGDDYIIMQDGSSNVDFSKVISLNQTSAMLWQEI
                     ENKEFDTDSVTEALTSRYDVDNESARRDAQKFIDSLDREGIIE"
     CDS             complement(4112..4552)
                     /locus_tag="ctg136_5"
                     /transl_table=11
                     /translation="MKKSIPNEILLPEVARLIKEGHTVTITVRGNSMNPFLVDRRDRVT
                     LGDFTTEQLQPGVTVLARDLTERIVFHRIIRRNGDILILQGDGNLAQTEETDIGRVMGV
                     MTEAMRKDKRYTADGKVWKLYSYWWMKLNPARRWLLALFRRI"
     CDS             complement(4579..5505)
                     /locus_tag="ctg136_6"
                     /transl_table=11
                     /translation="MRIQILDYQVGPHTFRMVKPSDFNIFKALPSLIPFITTIDTTQKV
                     IFETEIDDDETTTKRTIAKTPDDICFNWEDADCIIRPLPHSSHLVSITPRKSGKNYWME
                     CNDNFRQCFIHLPACRTETPAPENETNFVLNNFLMMLYAFNAARHHTLLMHASVVATET
                     GKGYLFLGKSGTGKSTHTGLWLQQFSDCHLLNDDNPIVHVDSLGKQATVFGSPWSGKTP
                     CYRKESMTVGAFVRLEQAPQNEIEQERAAHAFATLLPSCSCLKQNKEIYNAIVATVTEL
                     ATLAPVYHLKCLPDREATELCRKTVEG"
     CDS             complement(5752..8691)
                     /locus_tag="ctg136_7"
                     /transl_table=11
                     /translation="MQVACMATAALTAFSCSQEEFENSGRKGNITVNATFEGAGTDTRT
                     TVNDEYKILWQDTDALGLFCSNAESNYSNTKLEYASGAGQTSATFNGSKPSGETAVFSI
                     YPYQQNMSVSGNTLTMTLPATLTNYNGSSNGPMYAKVTNPDNLSALSFKHMAAMIKLTV
                     NKIPAEATTFKIIASNNIAGICTVDLTAADPILAVTSDESKEITASFTASADIKSRNFY
                     IPLPTGTYSSITAQLTNGSDKVYFTKTLNDKILGRRDILVVPPLDCVVVEATTPSALST
                     ALADSKNLPQEAPTAATVTDIAVSGSFNTTSGSNDGIAIPVLQNSDINLTFNTAPTTST
                     AAPLTLTDKTNTSVSAPAATATNSVSLAVPETTAEQEAPSVAITMPSTTVTLAAVGNKA
                     TYNEVTATTAQQTLIINAGVTVKKLTVKGGNLKIYGKVEQLVHDASDTTIYIIKGTEAS
                     LPATIDSKFVVQSDVAVLKTAFANGEDFKLSADADITGQSVSVPAGKSVVLDLNGYTLT
                     ADNSATGKIIVLGKMTLKDSSTEKKGKIVASQDYTAASYNGSLIEIAGEDASMTMESGN
                     ISAVRETPDSNGQYGVGVTDGGDFTMTGGKIEAGWFAVAGNGNYKTQNSIINITDGELI
                     STADYAVYLPQSGTTTISGGKVYGAAGGVCIQRGTLNVEGTALITSKGTGSTGNWGDGT
                     GGLDCAAINVSGAYGIATVNIKGGTLIAEAKSLITEGTTYTPVINVTGGTFSDPSVLKY
                     MATNATVDIKLLSNINIAKTELATGYILNAANATANLNLNGHDIINSSETADATPFTQI
                     FTVQNGTLNISGNGNVKCDASATAKDDGYRMVIEARGYGTVNIHGGSYYNTQKLNTQID
                     LIYARENGKINIYGGTFESGKYGTPNNDTDGRYWVLNLKNTDKNTASIQVSGGTFINFN
                     PANPNMDDNESYLVTGYEVTRDGSVYTAAHKVGDGRKEYIVGQTSQENR"
     CDS             complement(8726..8941)
                     /locus_tag="ctg136_8"
                     /transl_table=11
                     /translation="MKQNTPDGREAYITPSIEVIKMENEGVIATSGEPYHPITRSYSGS
                     TSTHSYNSASSSDLEDLINDILTVEN"
     CDS             complement(9306..9632)
                     /locus_tag="ctg136_9"
                     /transl_table=11
                     /translation="MKNCYGIDFRSWRKELRTREKTKQTPCKLPDRVSRSLQGVLFKVY
                     QISVLILLKKILFSFFSVCLPLFIRHIAAMLLRKTSSKTMQTVTKYLKELSGVRSDNSP
                     NSYK"
     CDS             10498..10830
                     /locus_tag="ctg136_10"
                     /transl_table=11
                     /translation="MKQLIACCGLDCENCAARIATVNNDDELREKTAKEWSVLNNTPEI
                     TPETIHCMGCRADGVKFTYCSDYCAIRKCVYEKGFNTCGDCKELDTCQVVGAVLQHAPG
                     ARENLY"
     CDS             11064..11840
                     /NRPS_PKS="Domain: oMT (51-145). E-value: 2e-11. Score:
                     34.4. Matches aSDomain: nrpspksdomains_ctg136_11_oMT.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 81.3; E-value:
                     1.3e-24)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg136_11"
                     /transl_table=11
                     /translation="MSNENKTIHDFEFNLICDFFSNMERQGPGSPEVTLKALSFVDGLT
                     DESLIADIGCGTGGQTMVLAGHVPGQITGIDLFPGFIDIFNRNARQLGLQDRVKGIVGS
                     MDALPFGEEELDMIWCEGAIYNIGFERGLKEWRKYLKPGGYIAVSESSWFTDERPAEIN
                     DFWMDAYSEMDTLPNQVTKLYKAGYLPVATFILPENCWTEHYFASKVAAQEIFRKKYAG
                     NKIAEEFSLLQMIEDELYGKYKEFYGYVFFIAKKVG"
     aSDomain        11217..11498
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg136_11_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.00E-11"
                     /label="ctg136_11_oMT.1"
                     /locus_tag="ctg136_11"
                     /protein_end="145"
                     /protein_start="51"
                     /score="34.4"
                     /tool="antismash"
                     /translation="DIGCGTGGQTMVLAGHVPGQITGIDLFPGFIDIFNRNARQLGLQD
                     RVKGIVGSMDALPFGEEELDMIWCEGAIYNIGFERGLKEWRKYLKPGGY"
     CDS             complement(11915..12763)
                     /locus_tag="ctg136_12"
                     /transl_table=11
                     /translation="MNISEFNINDEFIACNHITTNELNPLVEKPYHTKASIFALCTKGV
                     LKTIINHTQFRVEANALLVIPPETFVQLLHTSDDAEIYVVIFSQQLIQSSGAGKVMMDK
                     FHIIGKHYIFPLSKTDFQLYAEFMTYLSHLYQRTESPSSLVSLQTLLTYLLQGISELCP
                     ERPRIKETPGSRHFNQYRIFIRLVHTDYVREHQVSYYALKMNMRPAALCRLVKKESGYT
                     AMEIINNTIIMDAKAQLCTANTPIKDIAVSLGFNNAAFFNKFFKRHTGIPPQKFRTSSK
                     Q"
     CDS             complement(13047..13154)
                     /locus_tag="ctg136_13"
                     /transl_table=11
                     /translation="MPPYHMLIQLEFIHHLLIQTPDTIFQINHNNADGP"
     CDS             complement(13275..13550)
                     /locus_tag="ctg136_14"
                     /transl_table=11
                     /translation="MNQKCEFLRRQRIVTRRNPQIFKITRFYNHQIMFHVERPLKYLGA
                     AQRNIQQMLLCPFFQHIPKIEYNPHQLSIFMNSHHSTLYQKTDATL"
     CDS             complement(13679..14050)
                     /locus_tag="ctg136_15"
                     /transl_table=11
                     /translation="MPFKETFSKWNSIVFDSILDKSRISEINTINNWLFFSIKDVNSII
                     SCRDKSASPQASSVEKPTMAFSGVRISWLILARNTLFNSSLRCAFCKASFNLFSVSLYF
                     CVLMQIPMIRNGKSVNCPT"
ORIGIN
        1 taataactaa tatgaaacca actttattct tattggcagc cggtatgggc agccgttatg
       61 gtggcttgaa acaattggac ggattgggac cgaatggcga aactatcatg gattattcta
      121 tttacgatgc catcaatgcc ggttttggca agctcgtttt cgtaatccgt aaagattttg
      181 aacaggactt ccgcgacaag attatttcca aatacgaagg ccatattccc tgcgaactgg
      241 tattccagtc catagatgac cttcctgaag gcttcacctg ccccgaaggc cgtaccaaac
      301 cttggggaac caaccatgct gtaatgatgg gtgccgatgt aataaaggaa ccgtttgctg
      361 ttatcaattg cgacgatttc tacggtcgtg actccttcca ggtaatgggc aaattccttg
      421 cagcccttcc cgaaggctcc aaaaacgtat attccatggt aggcttccgc atcggcaata
      481 cgttgagcga gagcggtacc gtatcccgtg gattgtgtgg aacggatgcg aacaacctgc
      541 tgacttccgt agtggaacgt accaagattc agcgcatgga cggtgaggtg aagtacatcg
      601 acgataacgg tgaatggact gccactcccg agacgactcc ggtcagcatg aacttctggg
      661 gtttcactcc cgattatttt gcttacagtg cagagttttt caagagtttc ttgagcgacc
      721 cgaagaatat ggagaacctg aaaagcgaat tcttcatccc gctgatggtg gataagctga
      781 ttaacgatgg cactgctacc tgcgaagtgc ttgatacaac cagcaagtgg ttcggtgtga
      841 cttatcccga agaccgtcag agtgtagtcg acaagattca ggctttggtg gatgcgggcg
      901 agtatcctgc gaagctgttc tgagtttgtt aaccaaaggc agatacccgt tggggcttat
      961 tctctgatta taatcggaca atagattcgc atgcctccgc tactgccgga tggtgggtga
     1021 cgaagataca tgttttgcct gcgcagtctc tgcgcaggtt ttttattaac agccgttccg
     1081 tgtcggggtc gagggcagaa gtggcttcat ctaaaagaag aatgtttccg gggcgtagca
     1141 gagcgcgggc aatggcgatg cgttgggctt gtccttcact gagtccacca cctcgttcgc
     1201 tgagtgggga gtctacgccg tcgggaaggt ggaagacgaa gtcggcggtg gcggtttgca
     1261 gggcttgata tatggcttct tgagaagctt gtgggtttcc catcagcagg ttgtcacgga
     1321 tagttccgct gaaaagggta ttgccttgcg ggacatatac gaagttcttg cgggtttgcg
     1381 gagagacggt atgactggtt tcaagtggat gtttggcggg tatcaagagt atctgtccct
     1441 cttgtggcgt tgccagtgcc aacaatagcc ggatgagcgt tgtctttcct tttcctgttt
     1501 ctccgactat agctatgcag ctaccggcgg ggaaacggca ggagaagcgg ctgaataccg
     1561 gacggtcatc gggagtgtag cgaaaagtca cgtctttcag ttccagttcc ggggtagagg
     1621 cgaggaatat gctgtcacca tccgcttctg ccggcagtct ttccaattcc aatagccggt
     1681 ctatggcggt aagggcattg actacggaag gtatcaggcg tgagaggtcg aacacgggac
     1741 gctggacttt tcctaccaat tgcaaaaagg cggtcatcgt tccgaaggtg atacagcctg
     1801 cgctgaggtg aacggctccc caaagaaaag ccgtgaggta tccgccggaa aaggcaaggg
     1861 ccactaacat gtgggcagaa agcgagaaac gggtacgtcc catgacttgg ctgtggagca
     1921 tgtcttgcaa gtcatcgagt ttgtccagat gccgttcgcc ttgttccaat gttttaatca
     1981 ctatgcgatg ttgcaggctc tcttgtatga cggactggat gcgaccgtca ctgttccgaa
     2041 tatcatgtgt atagcgtttc attcgtcgca tatagaaacg gctgcctgat agaaagacgg
     2101 gcaggatggc aacaatcagc catggcagtg aagggtctaa aaagtagaag aatagaaagg
     2161 ctgccagcag ttgtatactc gtgacgatga atgccgggac agaagaggtg agcaatgtga
     2221 cgatggcggt ggtgtcttgt tctacccggt tcactacgtc tccggtatgg aaacgctcca
     2281 attcgttcca gcggctttgc agtaagcgcg agaagaggcg gtggcgaagg gcgttgcccg
     2341 tctctatctg catacgggta cttatccaag tgtcagcagc tccgcacagt aattgggcag
     2401 tcagcaggac aacggtgaga acggcgatat gcgtcaggtt gtcgtctgtt attccggtag
     2461 cggtgtctat cacccgtttg gttgcataga taaaggctag ggcaaaggcc acgcccagaa
     2521 tgccggtgag gcaacttagc aggatacgtc cgcgttgttc ggcagatacc tctcgaatat
     2581 acctaagttt ttcacgtctg tcctttttca cttttttgtc cttctgttgc tttttcattc
     2641 cttttatttt ccgggttctt ttatttcttt gtccttgctt tcttgtcttt tactcctttt
     2701 gatcggttta tttgtatagc tatcgttccc cctatcagag tcacgggata ccagagtgct
     2761 tcgtacggtg caaattgacg cagttcgttg cagcgtcggg tggcgcggca gaaggtgtac
     2821 cactttcctg cccaatatcc tttggggcgt ggcttgatgc ggttatcatg ttgcccgaag
     2881 ttaccggtag acaggatgtc ttccaataat tgttctccta tctgcttggt gccttccaag
     2941 gggaaaggaa gccggttggc gggcaatccc agtcgggtga cggcaatgta gccgaatgct
     3001 tgtgcggcat gcaatagtcc gaggtcctgc aactggcgaa gcagggtggt ggcatctatt
     3061 tctttgtggc gattggcaag cagacaagtc cagtcgcata gctggcgcag gccgattccg
     3121 ctgttcagga aatgtacaaa ggcatgcagg aagatataaa gtgcattgaa ggtggccgga
     3181 ggtatggcga tactgacggc cttcgagtcc tctttcccgg tttcggagaa tagggcatag
     3241 tctgtttcct gcgggtacca ttttctgata atctgctgaa agtaccggtt ggcaagcgga
     3301 ctgttcagcc ggaggatgat gcggtggttc tcgatgtgta ctcctttcaa actgtagcta
     3361 gcatgcttgt cggacgcttc tccctcgact atggcgcctt gttgcagcag gaggcggttg
     3421 gctatgggtt gcccttgttt tcctaaatag atgtcgatgt ctccgcattg ccggtgcaag
     3481 ggagtgcggt agttggtgcc gatgccttgc cctttcagca gtacgggatg cagcccggct
     3541 tcccggtaaa gggtattgag ttcgggcaga agctggttga ggcgtttgtt ggcttgttct
     3601 atctgtgcag tccgggcagc ccatttcaga tagaggacgc gtggagggcg cagttcggcc
     3661 ggcagactgc ttatgccgtc aaaagtcagt gcaagcaggg cttgtgagtt tgccatgcgg
     3721 tacacggttt cccagtcgtc cggcgagacc gaccggaaga gttgtcggtc tgccggagtg
     3781 ccccacaggc cggagcgtac caatgaaaag aaagcgtgtt gcatatccgt ccttattcta
     3841 tgattccttc gcggtcaagg gagtcgataa acttctgcgc atcgcgacgg gccgattcgt
     3901 tatctacatc atagcggctg gtcagggctt ctgtcacgct gtctgtatcg aactctttgt
     3961 tttctatctc ttgccaaagc atggcggaag tttggttcag gctgatgact ttgctgaagt
     4021 ccacgttcga cgagccgtct tgcatgatga tgtagtcatc gcctatccgg tgcaggataa
     4081 atccttgttt gattttcatg gttattttgt tttatattct tctgaacagg gcgagcagcc
     4141 agcggcgagc ggggtttagc ttcatccacc agtaggagta gagcttccag actttgccgt
     4201 cggcggtgta ccgtttgtct tttcgcatgg cttcggtcat gacgcccatt acccgtccga
     4261 tgtcggtttc ttcggtctgg gcgaggttgc cgtcgccttg caggatgagt atgtctccgt
     4321 tccgacggat gatgcggtga aagacgatgc gttccgtcag gtcgcgtgcc agtacggtga
     4381 cgcccggttg cagctgttct gtggtgaaat cgcccagtgt cacccggtca cggcggtcca
     4441 ctaagaaagg attcatgctg ttgccccgca cggtgatggt tactgtatgt ccctctttga
     4501 tgagacgcgc cacttcggga agcaatatct cgttgggaat gcttttcttc atcggctgtt
     4561 cagttcatca ttcataactt atccttctac cgtctttctg caaagttccg tcgcttcacg
     4621 gtcgggcagg catttcagat gatagacggg tgccagcgtg gcaagttccg tcacagtggc
     4681 gacaatggcg ttatagattt ccttgttctg cttcaggcaa gagcaggagg ggaggagggt
     4741 ggcgaaagca tgtgctgctc tctcttgctc tatttcattc tgcggtgctt gttccaagcg
     4801 gacgaaggcg cctacggtca tggattcttt ccgatagcaa ggtgtctttc cgctccacgg
     4861 agaaccgaaa acagtggctt gcttgccgag gctgtccaca tgtactatcg gattgtcatc
     4921 gttcagtaga tggcagtccg agaactgttg cagccagagc ccggtgtgcg tacttttgcc
     4981 cgtgccgctt ttccctaaga agaggtagcc tttgcctgtt tcagtagcga caaccgaggc
     5041 atgcatcagc agtgtatggt ggcgggcggc attgaaggca tagagcatca tcaagaagtt
     5101 gttcagtacg aagttcgttt cgttttccgg agccggtgtt tctgtcctgc aggccggtag
     5161 gtggatgaag cattgcctga agttatcgtt gcactccatc caatagtttt tcccgctttt
     5221 ccgtggggtg atggatacaa ggtgtgagct gtggggcaaa gggcgaatga tgcaatcggc
     5281 atcttcccag ttgaaacata tatcatcggg agttttcgct atggttcgtt ttgtcgttgt
     5341 ttcgtcatcg tctatctctg tttcaaagat tactttttgc gtcgtgtcta ttgtcgtgat
     5401 gaacggaatc agtgaaggca gcgccttgaa tatattgaag tcggaaggtt tcaccatgcg
     5461 aaaggtgtgc ggtcctactt gataatccaa tatctgtatt ctcatatgtt ttgattgtta
     5521 gttgttattc atgatacttt gggctactca gaaaaataat gaatgtttgt gtgaatgagg
     5581 aagatttgag agatttttca actgtcttgt tgtcattctt tagacgcgga ggacgcagat
     5641 ctataaaaga aaatccgctg tccgccgcat ttaaaagata gtaataaggc gattccgata
     5701 tctcttcgtt tggtttgcga ggatatattg cttcctttct tagaatttgg cttatcggtt
     5761 ctcctgactt gtttggccaa caatatattc tttcctccca tcaccgactt tgtgggctgc
     5821 tgtatataca ctgccgtcac gggtaacctc gtagcctgtt accaaatagg actcattgtc
     5881 gtccatattc ggatttgccg ggttgaaatt gatgaacgtt ccaccggaca cctggatgct
     5941 ggcagtgttc ttgtctgtat tctttaagtt cagtacccag tatctgccat ccgtgtcgtt
     6001 gttgggtgta ccatatttgc cggattcaaa tgttcctcca tagatattga ttttcccatt
     6061 ctctcttgca taaatcaggt ctatctgggt gttcagtttc tgggtgttat agtaagaacc
     6121 gccatgaata tttactgtcc cgtatcctcg ggcttcaatt accatgcgat aaccatcgtc
     6181 tttcgctgta gcagatgcat cgcacttcac attgccgttg cctgaaatgt ttagtgttcc
     6241 gttctgtaca gtaaagattt gtgtgaaagg agtggcatca gctgtttctg aggaattgat
     6301 gatgtcgtgg ccattcaggt ttaagtttgc cgttgcgttt gcagcattca atatgtagcc
     6361 tgtggcaagc tccgtcttgg cgatgttgat atttgagaga agttttatat ccacagttgc
     6421 gttggttgcc atgtacttca gtacgcttgg gtcggagaat gtacctccgg taacgttgat
     6481 gaccggtgta taagtggtgc cttctgtgat gagtgacttt gcttcggcaa tcagtgtacc
     6541 gcctttgatg tttactgtgg caatgccata tgctccactt acgttgatgg cggcgcagtc
     6601 cagtcctccg gtaccgtcgc cccagttgcc ggtgctacct gtgcctttac tggtaatcaa
     6661 ggctgtacct tccacattca gagtgcctcg ttggatgcat acacctcctg cggcaccata
     6721 aaccttgccg ccactgatgg tcgttgtgcc ggattggggc agatagactg catagtcagc
     6781 agtagaaatg agttctccgt ctgtgatgtt gatgatggag ttctgcgtct tgtaattgcc
     6841 gttgcctgcc actgcaaacc atccggcttc tatcttgccg cctgtcatgg tgaagtctcc
     6901 accgtccgtc actccgacgc catattggcc gttactgtcc ggagtctctc tgactgcact
     6961 gatgttgccg ctttccatgg tcatggaggc atcttcaccg gctatttcaa tcagactgcc
     7021 attataagaa gccgctgtat aatcctggct ggcaactatc ttgcctttct tctcggtaga
     7081 gctgtccttc agtgtcatct tgcccaagac gatgattttg cctgttgcgc tgttgtcggc
     7141 agtcagtgta tatccgttca agtcaagaac cacggacttt ccggcgggta cactgacgct
     7201 ttgccctgtg atgtcggcat cggcggacaa tttaaaatct tcgccgttgg cgaaagcggt
     7261 ctttaggact gccacgtcgg attgaactac aaatttgctg tcgattgttg ccggaagtga
     7321 tgcttcagtt ccttttatta tatagattgt ggtatcgctg gcatcgtgta ccaattgttc
     7381 tacctttcca tatatcttca agttaccgcc ttttacggtc agcttcttta cggtgacgcc
     7441 tgcattgata atcaatgtct gctgggcggt agtggcagtc acttcattgt aagtggcttt
     7501 attgcctact gctgccaatg taacggtggt gcttggcatg gtgatggcta cagaaggagc
     7561 ttcttgctct gctgtggttt ccggtacagc caaggataca ctgttggtgg cagtggcggc
     7621 gggagcactt acgctggtat tggtcttgtc ggtcagcgtc aacggagcgg cagtactggt
     7681 cgttggggct gtattgaacg tcaggttgat gtccgagttc tgtaaaaccg ggatggcgat
     7741 gccgtcgttg ctgccagaag tggtattgaa gctgccgctg actgcaatgt cggttacggt
     7801 tgctgctgtc ggtgcttctt gtgggagatt ttttgaatca gctaaagctg tactaagcgc
     7861 actgggggtt gtagcctcta ccacaacgca atccaaagga ggtactacca atatgtctct
     7921 tctccctaag attttgtcat taagcgtctt ggtaaaatat accttgtcgc ttccattcgt
     7981 cagttgggca gtgatggaac tataagtacc tgtgggcaaa ggaatgtaga agttgcgaga
     8041 ctttatatca gctgaggctg tgaaggaggc ggtgatttcc ttgctttcat cgctcgttac
     8101 tgccagtatc gggtctgctg cggttaagtc taccgtacaa atacctgcaa tgttattgga
     8161 ggcaataatc ttgaaagtag tggcctctgc cggaatcttg ttgacggtca gttttatcat
     8221 ggctgccatg tgcttgaagg acagagcgct cagattgtcg ggatttgtca ccttggcata
     8281 catcgggcca ttgctgctgc cgttataatt tgtaagcgtg gcaggtagag tcatggtcaa
     8341 tgtattgccg cttacgctca tgttttgttg gtaaggatag atggagaata cagccgtttc
     8401 tccgcttggc ttgctgccgt tgaaagtggc ggaagtttga ccagcaccgc ttgcatattc
     8461 taattttgta ttgctataat tactttctgc attactacag aacaacccta gggcatcggt
     8521 atcttgccat agaatcttgt attcatcgtt tacggtagta cgggtgtcgg tacctgcgcc
     8581 ttcaaacgtt gcgttaacgg tgatgtttcc tttccgcccg ctgttttcaa attcctcttg
     8641 gctgcaactg aatgcggtca aggcagcagt tgccatgcag gcaacttgca taaggtttct
     8701 taatttcatc ataatgaagt cccccttagt tttctacggt taagatgtca ttgattaggt
     8761 cttccaagtc gctgctggat gccgaattgt agctatgggt agaggtgctg cccgaatagg
     8821 agcgcgtaat gggatggtaa ggttcgccgc ttgttgcaat gactccttca ttctccattt
     8881 tgataacttc gatagacgga gtgatgtatg cttctctacc gtctggtgtg ttctgtttca
     8941 tatacacaaa ttatttaaag gttaaacaat aaaaaaaacg tgagtaacta tgtttgtata
     9001 tcctttattc aggccttcgc attgcccttt ccctggatat acaacagtca ctcacgtcgt
     9061 ttgtgtatat accatccccc tgatgggaga aaaccatata aacatagacg tgagcatcct
     9121 tgttgttatc ttcagggaaa ttttcaaagt tgcgaagttt gaataaagaa gataatttca
     9181 ataatgctct tactaatatg taaataaacc cactacgcta tagcggattt gtgacaaaga
     9241 taattgtttt ttgtttaagt gtatctatgt ttctctattt tttttgggaa aggctcacgt
     9301 ctctttcatt tataggagtt aggagagtta tcacttctaa ctcccgataa ctccttcaaa
     9361 tatttagtaa ctgtctgcat tgtctttgag gatgtttttc tgaggagcat agcggctatg
     9421 tggcgaataa agaggggaag acagaccgaa aagaagctga ataaaatctt tttaagcaaa
     9481 attaaaacag agatttgata tactttaaac agaacaccct gcaaactccg gcttactctg
     9541 tccggcagtt tgcagggtgt ctgcttggtt ttctcgcgtg tacgtagctc cttacgccac
     9601 gaacggaagt cgatgccata gcaatttttc ataataagac tttccatatt tttgcaaatg
     9661 tccgtactgc ctttggctga aacaatttat ataagtaatt gaagtttcgt aagtgagtat
     9721 gcctgctgat aaatgggaat ttatcgcaca gagcgcgaag cctgctctca taacctatgg
     9781 agagcacgag tgaaagcttg tggattttta tctaaaacat aggtattcct ttgctcttct
     9841 ccctttgttt gtctgctgtg gcatagggaa tttatgacgc ctaacggcca tgaacaaccc
     9901 tgctttcggc cataaagcga tcgcttgacg accgtaagca gggttgttca tggccgttag
     9961 gcgtcactaa ctccagagct attgcggatg aagtacgtag cccgaaccta ttgcgcacaa
    10021 ggcgcaaacg tattatacaa cggtgtaaaa gacattagag tgcattattc atagtcggcc
    10081 tttgactccc gataactcct actatgcccc tacagtccaa ctccatatct gttgacttca
    10141 cagtaaggac aagcccgaaa atgcaggaaa accgaacctg ccgattcatg taatctgcat
    10201 gcagtattat ggtaggggat agcagcttac tgcaaaactc aggcgtttca ggcaggtgga
    10261 agcaaatttt gcttccacct tttcaggttg cttccaccgc agggcaaatg ccgatggaca
    10321 gggggatgca ggaggtgggt ggaagtgtgg aagcaaagtg atggaaaatt aatttggcat
    10381 tcacacaata ataaccgtat atttgtagca tggctgtctg cctcctctta aattcagata
    10441 aagaggaggt agacaaatgc ttgctatgag aaacacataa atggttataa ccaagtgatg
    10501 aaacaattaa ttgcatgttg cgggttggat tgcgaaaatt gcgccgcccg tatagccact
    10561 gtcaataatg acgatgagct gagagagaaa accgccaaag agtggagtgt gctgaacaat
    10621 acgccggaaa ttacgccgga aaccatccat tgtatggggt gccgtgcaga cggggtgaag
    10681 tttacctatt gcagcgatta ttgtgctatc cgcaaatgtg tgtacgaaaa aggtttcaat
    10741 acttgtggcg actgtaagga actggatact tgccaggtgg taggtgcggt tcttcagcat
    10801 gcgcccggtg caagggaaaa tctttattaa ccgtaaaatc tttgattaaa taaaatattg
    10861 cttatctttg cagtatgaca aagacattta aatcggattt ggttttgtaa acaatctgtg
    10921 ttccatgcac agattgtccc tttcgtttac tttcggataa cttctttcga gagtgttttt
    10981 ctattgttat aattcaagtt taatccgcat attatgctga aggtgttgtg atactttccg
    11041 tatatgcaaa atatagtaag aaaatgagta acgaaaataa aaccatccac gatttcgaat
    11101 ttaatttaat ctgtgacttt ttctccaata tggaacggca aggccctggc agtcctgaag
    11161 tgacgttgaa ggcattgagc tttgtagacg gtcttaccga tgaatccctt attgccgata
    11221 tcggttgtgg aacgggtggt cagacaatgg tattggctgg ccatgttccg ggacagatta
    11281 ccggaattga ccttttcccc ggctttattg acatcttcaa ccgtaatgca aggcagttgg
    11341 gcttgcagga cagagtaaaa ggaattgtcg gttcaatgga tgccctccct ttcggtgagg
    11401 aggagctgga tatgatttgg tgtgaaggtg ctatctataa catcggcttt gaacgtggct
    11461 tgaaggagtg gcgtaaatat ctgaaaccgg gagggtatat tgccgtatcc gagagttcat
    11521 ggtttacgga cgaacgtcct gcggaaatca atgacttctg gatggacgcc tattctgaaa
    11581 tggatacact tcccaatcag gtgaccaagt tgtacaaggc aggttatctt cccgttgcta
    11641 cattcatttt gccggagaat tgctggacag agcattactt tgcttcaaag gttgcggctc
    11701 aggagatttt ccgtaagaaa tatgccggta ataaaattgc cgaagagttc agcttactcc
    11761 aaatgattga ggatgaactg tacggcaagt ataaggaatt ttacggttat gtgttcttta
    11821 ttgccaagaa ggtaggctga tgacggactt ctcttattga ggaatgcggg tattctcagg
    11881 acagaatatc cgcattttgg gttttgagta gattttattg ttttgaggat gtacggaact
    11941 tctgaggagg tattcccgta tgacgtttaa agaatttgtt gaagaaggcc gcattattaa
    12001 aacctagact cacggctata tcctttatcg gagtgttggc ggtacaaagt tgtgctttgg
    12061 catccatgat gatagtattg ttgatgattt ccatggctgt atatcctgat tcctttttga
    12121 caaggcggca aagagctgcc ggtctcatat tcattttcaa tgcataatag gacacttgat
    12181 gctcccggac atagtctgtg tgtaccaatc ggataaaaat gcggtattgg ttgaaatgcc
    12241 tgctgcccgg agtctctttt attctagggc gttccggaca gagttcggat ataccttgta
    12301 acagataggt cagtagagtt tgcaatgaaa ctagacttga ggggctttct gttctttggt
    12361 agaggtgtga caaataggtc atgaactcgg cataaagctg gaagtccgtt ttcgatagag
    12421 gaaaaatata gtgtttgcct ataatgtgaa acttatccat catgaccttg ccggcccctg
    12481 aactctggat aagttgttgg gaaaatatga cgacatatat ttcagcatcg tctgacgtgt
    12541 gtagcaattg tacgaaggtc tcgggaggaa taactaggag ggcgttagct tcaaccctga
    12601 attgagtatg gtttatgata gttttcagaa ctcctttggt gcatagagcg aagatactgg
    12661 ccttggtgtg gtatggcttt tccactagcg gattcagttc attggttgtg atatgattgc
    12721 aggcaatgaa ctcgtcattt atattgaatt cggatatatt catgttggag attttaagac
    12781 gcaaaaatgg gggataataa tgtataaatg acagaggtaa cagttaaaat caatattacg
    12841 ctcaacttat ctctgttaaa taaggtaaag ttgtgaataa tagaatatat acatattaaa
    12901 atggaatatt gatttataag ggtttgtttg tggtataagc attttaaccc gaactttgct
    12961 ccttgtatga taaaacaatt ctgatgaatc cgaatgttcc tcaagaagta cgtataataa
    13021 atgccatctc cgagcagttg ttcaactcat ggcccgtcag cattattatg attgatttgg
    13081 aagattgtat ctggcgtctg aatcagcagg tgatgaatga actccaattg aatgagcatg
    13141 tgatagggcg gcatatcact gacttattgg aagtggtatg tgataaaaag aatgtgttgg
    13201 aagccctttt gctgcaactt cgggagaggg atgtacggat tattcccttg gataccaatt
    13261 gctttatacg tgaattaaag agtggcatca gttttctgat acaaggtgct atggtgggaa
    13321 ttcatgaaga tggacaattg gtgaggattg tactctattt taggaatgtg ttggaagaac
    13381 ggacacagaa gcatttgctg aatattgcgc tgagccgcac ccagatattt caatggtctt
    13441 tcgacatgga acataatctg atgattatag aaccgcgtta ttttgaatat ttggggattc
    13501 ctacgcgtga ctatacgctg acgcctgagg aattcgcatt tctgattcat ccggacgacc
    13561 ggaagggagt gtttgatgct ttggctttac agttgcgtgg taatttgtac gaacgcccag
    13621 tggaataccg tctacggagg ggagacggca agtgggagtg gtttgaggcg caatctacct
    13681 atgtgggaca attgacggat ttgccgttcc gtatcatcgg tatttgcatg agtacgcaga
    13741 aatacaagga tacggagaat aaattgaacg aggctttgca gaaagcgcaa cgtagcgatg
    13801 agttgaagag cgtatttctt gctaatatga gccacgagat acgtacgccg ctaaatgcca
    13861 ttgtgggctt ctctacacta ctggcttgtg gggatgccga cttgtcacgg caggagatta
    13921 tggaattcac gtctttgatt gaaaagaaca gccagttgtt aatggtgttg atttcagata
    13981 ttctggattt gtccaagata gaatcgaaca cgatggaatt ccattttgag aaggtttctt
    14041 taaatggcat attggaaagc atttacagtg cgcagaagat gaatcttcgg aaaggagtg
//
