LOCUS       c00373_gnlPro..        10704 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AOHANEMP_373.
ACCESSION   c00373_gnlPro..
VERSION     c00373_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 10:06:49
            Original ID  :: gnl|Prokka|AOHANEMP_373
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10704
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10704
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3058:6373]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3059..6373
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..10704
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..10704
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             2..607
                     /locus_tag="ctg373_1"
                     /transl_table=11
                     /translation="ADVEALMACKAEAGETVDEALKTLILVIKENIKVRRFTRYEGVCS
                     AYVHGGGTHGILVNFETTNDIDAKDEFVAYGKDIAMQVAAANPGYVDEASVPAEVVAKE
                     KEIMLAQMAQDPKTANKPEAVKEKMIEGKIKKFFKENCLVDQEFVKDSDLTVAQYTAKV
                     AKDLGGEIKIVKFARFVKGEGLEKRADDFASEVASMVK"
     CDS             complement(736..2796)
                     /locus_tag="ctg373_2"
                     /transl_table=11
                     /translation="MLHYIKKSYISGQSAKLYLYSAHEKPVKYAKEVEAILKRISVKFQ
                     QQEQTYRSLHAAARSLLSSKGRVFLLFLLFYKVLTNLLFVPVLQLIWAMTLRFAPIRYL
                     NNKTASRIFASPAIIVCIAVLAVLAAFWSLYEIAAMLQLLTRMRHGGPLRAGAVFRDAF
                     RSLVRVFLPQNLPLLLYGVALIPLTNFFLAANHLTQFAVPEYLWGLLKARAANRFLFAL
                     AVLCVLALLLDGLVVLPKFLLERKSFGCAFAESLRVLRSRTGQLLALAPRWMLTATVRT
                     GLMLLCGALLFYCVILGVGFASTAALLALSRAALLIELPFLCLLMDCAMTAAQSTLTEA
                     LYEVTRQPDAILATISGELPALPREQTVLVRMMACAALVTCGVAAVYLLFPQTQPLQSV
                     LGLSDPVITYHRGYSSRAPENTMAAFETALEHGSPRIELDVQMTADGVAVVTHDTSLRR
                     CTGCNANIYDLPYAQVQQLDAGRWFHRQFTGSYIPTLEEVLALCKGKAELNIEIKPSTF
                     TPTLEAETVRLIHAYDYGADCVVTSQSYETLCKVKELDPDITTGYILALGVGTYYDLPA
                     ADFFSVESTFITAGMVQQIHLRGKTISAWTINRQQDAEKLLQLGVDDLITDKPEIIAPL
                     LARDKALDNRLLWLRDQIQELLAAPDAEEAMEVEETIEDAIEDPEEVLDEA"
     CDS             3059..4378
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg373_3"
                     /sec_met_domain="CT_Vparvula (E-value: 1.1e-66, bitscore:
                     215.0, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASKINKGEILAKFFDDGEYTALFADGAVSAACGYAAGQQAYAVY
                     QNGEAVTVKDVEKNIKVLEMAAQTGCPVVTFYNSVGAKLAEGLDVLTASAKLNAQIAKV
                     SGVVPQVAVVLGVCGGTSALSAANADVCIMAEGAELFFTAPFTSAAKGDKVADAGSAAA
                     AAKAGVASIVAADAAEAAEKAAHIVGLLPANNLTGPAIFEFEQPTAVLAVGAEPAKAAA
                     AVIDKDSAVELYAGFGKSVYTAFATIGGNAVGVVATGKQLCHNCVAKASRFVRLCDAFS
                     VPVVTIVDTEGFVPSVTDDVAGGIREAARLAATYADATTAKVAVLAGKAVGPVYTTLAA
                     ADLRIAVTGCTVSALEPSAAVSVLYKDEIDASDNIIAATKAKAAAYTAEVCSAASAVAA
                     GAADMSCDAANVRASVVAALELLSTKRAARLPKKHGNMAL"
     CDS             4430..4846
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg373_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 6.1e-13, bitscore:
                     38.1, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYYNITVNGVAYSVSVEETAAGAAPVAAAPAAPKAAPAPAAAPK
                     AAAGAAGAVAVKAPMPGNILDVKVAAGASVKAGDVLVILEAMKMENEXXXXXXXXXXXX
                     XXXXXXXXXXXXXXXXXXXXXXSRPVTCWSSSRP"
     CDS             4822..4953
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 53.8; E-value:
                     4.2e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg373_5"
                     /sec_met_domain="Biotin_lipoyl (E-value: 7.5e-18, bitscore:
                     53.8, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VLVILEAMKMENEIVAPQDGTVASINVNKGDTVNSGDVLVSMN"
     CDS             4970..6373
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg373_6"
                     /sec_met_domain="HMGL-like (E-value: 6.4e-48, bitscore:
                     153.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 8.2e-58, bitscore:
                     184.9, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKKPIKVTEVVLRDAHQSLLATRMTMDEMRPILPEMDKINYFSV
                     ECWGGATFDSCIRFLDEDPWERLRILRKELPHQKLQMLFRGQNMLGYRPYADDAVEYFV
                     QKSVANGIDVIRIFDALNDPRNLQTAIKSANKEGAHVQGCISYTLSPVHNNEYFAAYAK
                     TLEEMGANSICIKDMAGLLTPYTCYDLVKKLKETVSIPVDIHSHYTAGLASMSILKGIE
                     AGADIIDTAMSPLSLGTSHMPTESLVAALQGTDYDTGLDLKQLNVVRAYFAKLREKYIA
                     NGQISPKSLGVDANTLLYQVPGGMFSNMLKQLKDAGKEDKLDEVLAEIPRVREDAGYPP
                     LVTPTSQIVGTQAVFNVIMGERYKMVTKEFKGLVHGDYGKTPAPIKPEFTKKILGDEQP
                     ITCRFADTLAPEMDKLKAEAAKWATQEEDVLTYAMFPQVAPKFFDKRNAKKQGVDGDHV
                     DYTNQSHPV"
     CDS             6569..6910
                     /locus_tag="ctg373_7"
                     /transl_table=11
                     /translation="MRSIPEQRIAEFQEQDYQLYFGISKLEFDRMLKALHEAYRQEHKR
                     KTRFTKISMMDKLILTLIYRYEYRTMESIAKEYEVSLDTIADNIHWVERTLLNADILQT
                     SVTCVYKTN"
     CDS             7179..8057
                     /locus_tag="ctg373_8"
                     /transl_table=11
                     /translation="MILSMTGFGRGTAVLNGREITVELRSVNSRYFEYSSRIPRTCSSL
                     DSRLKKQLNQRISRGKVELSMTVQNVDAADTVVAVNMELARSYQQAMRDLSEQLGVKND
                     VSTAVLTRFPDVLTTRHADVDEEQLWQDVSAVTAQALDRFVEMRAAEGAKMKADVESRL
                     VFLEQCVGKVESLSAGRVENYTNRLYEKLKVILQDRDIDDARVLTEAAIFGDKTAVDEE
                     TVRLRSHIAQYRDILQLDEPVGRKLDFLTQELNRETNTIGSKCQDLDITRIVVDMKAEI
                     EKIREQIQNLE"
     CDS             8076..8354
                     /locus_tag="ctg373_9"
                     /transl_table=11
                     /translation="MKLINIGFGNMVSAGRVVAVVSPDSAPVKRLVKEARERGMLIDAS
                     YGRSTRAVLIMDSDHVVLSALQPETVASRAAGQEGRASMEEETSHGE"
     CDS             8344..8916
                     /locus_tag="ctg373_10"
                     /transl_table=11
                     /translation="MANDKFLFVVSGAAGTGKDSVVKALREAHPEIEKTVSATTRAPRP
                     GEQEGVDYYYRTREQFQQLLENDQVVEHNFYNGNYYGTLKSEVEKRLEAGKVVVLVIDV
                     HGAANIRRMFPGATTVFLLPPSVEELEHRLRGRGTETEESIQERLATARQELAEQDKFT
                     VKLVNNQIEPCAAELYQVICQRAGLQE"
     CDS             8945..10702
                     /locus_tag="ctg373_11"
                     /transl_table=11
                     /translation="MPKTVGVAVSNATFHFDKLYTYAVLPEHQNVVRLGSMVLVPFGKG
                     SRARMGVVLACDAEPEYSKLKYLFDVAPASACLTPELLRLVYFLKERTFCTYYEAVKAV
                     IPYGAQYKPAVAADGVTPVLQKQLTRHTENAYKLVGTLPQKPKPTAKQLAAVALLSGGP
                     RTLNELEDKGISRAVLDNLCTKGVLECSKVNKSIDLYASIPLRNDPITLTEQQQAAYDT
                     LLPKLEDTAPHSALLYGVTGSGKTLVFLKLISRCLELGRKALVLVPEISLTPQMILRLK
                     GQFGRRVAVQHSALNHTERLLQWQMIQDGGADIVVGTRSAVFSPLENIGLIIIDEEQEH
                     TYRSESAPRYSAHEVARQRAAENGALLLLASATPSTESFYAAQNGRTQLVRLTKRYGGN
                     PLPSVQIVDMRAELAAGNPREISLALEDAIRRNLEAEKQTILLLNRRGYQTIAQCEDCR
                     EVLKCPKCSVPMVYHKSAHKVLCHYCGSQQEPPPTLCPACGGKLQYRGFGTQKAEEELA
                     KLFPEARVLRMDQDSTAAKDAHEKLLAKFAAHEYDIMVGTQMVAKGQDLEDETLVGVLG
                     IDSLLFAQGF"
ORIGIN
        1 cgctgatgtc gaggctctga tggcttgcaa ggccgaggct ggcgagactg ttgacgaggc
       61 tctgaagacc ctgattctgg tcatcaagga gaacatcaag gttcgccgct tcacccgtta
      121 cgagggcgtc tgctctgcat acgtccacgg cggcggcacc cacggcattc tggtcaactt
      181 cgagaccacc aacgacatcg atgctaagga cgagttcgtt gcttacggca aggacatcgc
      241 catgcaggtc gctgctgcta accccggcta cgtcgacgag gcttctgtcc ccgccgaggt
      301 cgtggctaag gagaaggaga tcatgctggc tcagatggct caggatccca agaccgctaa
      361 caagcctgag gctgtgaagg agaagatgat cgagggcaag atcaagaagt tcttcaagga
      421 gaactgcctg gtcgatcagg agttcgtcaa ggacagcgac ctgaccgttg ctcagtacac
      481 cgctaaggtc gctaaggatc tgggcggcga gatcaagatc gtcaagttcg cccgctttgt
      541 caagggcgag ggtctggaga agcgtgctga cgacttcgca tctgaagttg caagcatggt
      601 gaagtaattt aaacttccaa agacaaaagg ggagccgcag tacctgtaac agggtgctgc
      661 ggctcctttt tatgtttatg aaaatgcaaa taccgggcag cccgcagcct gcccggtatt
      721 actgtataaa tcttcttacg cttcgtccaa aacctcttcg ggatcctcaa tagcgtcctc
      781 gatggtctcc tcgacctcca tcgcttcttc agcgtccggg gcggcaagca actcctgaat
      841 ctgatcccgc agccagagca gacggttgtc cagtgccttg tcccgtgcca gcagcggcgc
      901 aatgatctca ggcttatcag tgatcaggtc atccacaccc agctgcagca gcttttccgc
      961 atcctgctgg cggttgatgg tccatgcaga gatggtcttg ccgcgcagat ggatctgctg
     1021 caccataccg gcggtgataa aggtggattc cacgctgaaa aagtctgcgg caggcaggtc
     1081 gtagtaggtg cccacgccca gcgccagaat ataccctgtg gtaatgtccg ggtccagctc
     1141 cttcaccttg cacagggtct cgtagctttg agaggtgacc acgcagtccg cgccgtagtc
     1201 gtatgcgtgg atcagccgca ccgtttcggc ctccaatgtc ggcgtaaagg tgctgggctt
     1261 gatctcaatg ttcagctcag ccttgccctt gcacagcgcc agaacctctt ccagcgtagg
     1321 aatataggag cccgtaaact gccgatggaa ccagcgcccg gcatccagct gctgcacctg
     1381 tgcatagggc aggtcataga tgttggcgtt gcagccggta caccggcgca ggctggtatc
     1441 gtgggtcact acggctacgc cgtcagcagt catctgcacg tccagctcaa tgcggggact
     1501 gccgtgctcc agcgcggtct cgaaggcagc catggtgttc tccggcgcac gggaagaata
     1561 gccccggtgg taggtgatca ccgggtcaga aagacccagc acgctttgca gcggctgtgt
     1621 ttgcgggaaa agcagatata ccgctgctac gccgcaggtg accagtgcgg cgcaggccat
     1681 catcctgacc aacaccgtct gctcacgggg cagggcgggg agctctccgg aaatggtcgc
     1741 cagtattgca tcgggctggc gggtcacttc atacagtgcc tctgtaaggg tactctgcgc
     1801 cgccgtcatg gcacagtcca tgagcaggca aaggaacggc agttcgatca gcagtgccgc
     1861 gcgagaaagt gccagcaggg cagcagtgct ggcaaagccg acaccaagaa tgacacaata
     1921 gaacagcaaa gccccgcaca gcagcatcag cccggtgcgc acggtagcgg tcagcatcca
     1981 gcgcggtgcc agtgcaagca gttgcccggt gcggctgcgc aaaacccgca gactctccgc
     2041 aaatgcacag ccaaagcttt tacgttccag caggaacttt ggcagcacta caagcccgtc
     2101 cagcagcagc gccagcacac aaagcactgc cagagcaaat agaaaacggt tggcagcgcg
     2161 cgccttcagc agcccccaga gatattccgg cacggcaaac tgggtcagat gattcgcggc
     2221 aagaaaaaag ttcgtcaacg ggatcagggc aacgccatac agcagcagcg ggaggttctg
     2281 cggcagaaac actcgcacaa ggctgcgaaa ggcatcccgg aacaccgccc ccgcccgcag
     2341 cggtccgccg tgccgcatcc gcgtcaatag ttgcagcatc gcggcgattt catacaggct
     2401 ccagaaggct gccagtaccg ccagcacagc aatgcacacg atgatggcag gggaggcaaa
     2461 gatgcgggat gcagttttgt tgttgaggta gcggatgggc gcgaaccgca gcgtcatcgc
     2521 ccagatcagc tgcaataccg gtacgaacag gagatttgtc agtaccttat aaaacaacag
     2581 aaaaagcaga aatacccgcc cctttgacga aagcagggaa cgagcggcag cgtgcagaga
     2641 gcggtaggtc tgctcctgct gctggaactt tacggaaatt cgcttcaaga tagcttcaac
     2701 ctcttttgca tatttgacgg gcttttcgtg tgcgctatat aggtacagtt tggcagattg
     2761 cccggaaata tatgattttt taatatagtg taacataaac gcaacggaaa gaaaacgcag
     2821 cagacgggtg cagttttgcc aaaaaaaccg ggaaaatttc tacacccaca aaatgggcgt
     2881 gtgatagcat ttgtccagat aaaacgtgca aaacgatgaa tcgttaaaaa tttgagtatc
     2941 tataagtgac ggatgttgaa tcgcatggaa ttttatagaa tcccttgcat ttttttgcca
     3001 gcttctgtat aatgaatata attttgaaag ctcacacaga caaccaggag gtctaattat
     3061 ggcttcaaag atcaataagg gagaaatcct cgccaagttc ttcgatgacg gggagtacac
     3121 tgcactgttt gctgatggtg cagtgagcgc tgcctgcggc tatgctgcag gtcagcaggc
     3181 ttacgccgtt tatcagaatg gcgaggctgt caccgtaaag gatgttgaaa agaacatcaa
     3241 ggttctggaa atggctgcac agaccggctg cccggtggtc accttctata actcggttgg
     3301 tgcaaagctg gccgagggtc tggacgtgct gaccgccagc gcaaagctga atgcacagat
     3361 cgcaaaggtc tccggcgttg ttccgcaggt ggccgttgtt ctgggtgtct gcggtggtac
     3421 cagtgctctg agcgctgcca acgcagacgt ctgcatcatg gccgagggcg cggagctgtt
     3481 cttcaccgct ccgttcacct ccgctgccaa gggcgataag gtcgccgacg caggcagcgc
     3541 cgcagctgcc gcaaaggcag gcgtagcttc catcgtggct gccgatgccg cagaggctgc
     3601 tgaaaaggct gctcacatcg tgggtctgct gcccgccaac aacctgaccg gcccggcaat
     3661 cttcgagttc gagcagccca ccgctgttct ggccgtcggt gccgagcccg caaaggctgc
     3721 tgccgctgtg atcgataagg acagcgctgt ggagctgtac gcaggctttg gtaagtctgt
     3781 ttacaccgca tttgcaacca tcggcggcaa cgccgtgggc gttgtggcaa ccggtaagca
     3841 gctgtgccac aactgcgtag ccaaggcttc ccgctttgtg cgcctgtgcg atgccttcag
     3901 cgtgcctgtg gtcaccatcg tggataccga gggctttgtg cccagcgtta ccgatgacgt
     3961 ggctggcggc atccgcgagg ctgcccgtct ggccgctacc tacgccgatg ctaccaccgc
     4021 aaaagtggca gtgctggccg gcaaggctgt gggccctgtg tacaccactc tggctgctgc
     4081 cgatctgcgc atcgctgtga ccggctgcac cgtcagcgca ctggagccca gcgccgctgt
     4141 cagcgtgctg tataaggatg agatcgatgc ttccgacaac atcattgccg ccaccaaggc
     4201 taaggctgct gcctacaccg ctgaggtgtg cagcgctgcc agcgcagtgg ccgccggtgc
     4261 tgccgatatg agctgtgatg ccgctaatgt gcgcgccagc gttgtggctg cactggagct
     4321 gctgagcacc aagcgcgctg cccgcctgcc caagaagcat ggcaatatgg ccctgtaagc
     4381 gtccgaatgt aagttaattg agttcgattt tgaattggag gatccttcca tgaagtacta
     4441 caatattact gtcaatggtg ttgcttacag cgtttccgtt gaggaaactg ccgcaggcgc
     4501 tgctcctgtt gccgctgctc ccgccgcacc caaggctgct cccgctccgg cagctgctcc
     4561 taaggcagcc gccggtgcag ccggtgctgt tgccgtcaag gctcccatgc ccggcaacat
     4621 tctggatgtc aaggtcgctg ccggtgcttc tgtcaaggcc ggtgacgtgc tggtcatcct
     4681 cgaggccatg aagatggaga acgagannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4741 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4801 nnnnnngtca aggccggtga cgtgctggtc atcctcgagg ccatgaagat ggagaacgag
     4861 atcgttgctc cgcaggatgg caccgtggct tccatcaacg tgaacaaggg cgataccgtc
     4921 aactccggtg acgttctggt ttccatgaac taaggaagag gtgacaacca tggcaaaaaa
     4981 gccgatcaag gtgaccgagg tcgtcctgcg tgatgcgcac cagtctttgc tggctacccg
     5041 tatgaccatg gacgagatgc gccccatcct gcccgaaatg gacaagatca actacttctc
     5101 cgtggagtgc tggggcggcg ctacgttcga cagctgcatc cgcttcctgg acgaggatcc
     5161 ttgggagcgt ctgcgcatcc tgcgcaagga actgccgcac cagaagctgc agatgctgtt
     5221 ccgcggccag aatatgctgg gctaccgtcc ctacgcagat gacgctgtgg agtactttgt
     5281 acagaagtct gttgccaacg gcatcgacgt catccgcatc ttcgacgctc tgaacgaccc
     5341 ccgcaacctg cagactgcca tcaagtctgc caacaaggaa ggcgctcatg tgcagggctg
     5401 catcagctat accctgagcc ccgtgcataa caacgagtac tttgcagcct acgccaagac
     5461 tttggaggaa atgggcgcaa actccatctg catcaaggat atggccggtc tgctcactcc
     5521 ctatacctgc tatgatctgg tcaagaagct gaaggagact gtcagcatcc ctgtggacat
     5581 ccacagccac tacaccgcag gtctggcttc catgtccatt ctcaagggca tcgaggcagg
     5641 tgccgatatc atcgatactg ccatgagccc cctgagcctt ggtaccagcc acatgcccac
     5701 tgagagcttg gtggctgccc tgcagggcac cgactacgac accggtctgg atctgaagca
     5761 gctgaatgtc gtgcgcgctt actttgcaaa gctgcgtgag aagtacatcg ccaacggcca
     5821 gatcagcccc aagagtctgg gcgtggacgc caacaccctg ctgtatcagg tgccgggcgg
     5881 tatgttctcc aacatgctca agcagctgaa ggatgccggc aaggaagaca agctggacga
     5941 agtgctggcc gagattcccc gcgtccgtga ggatgcaggt tatccgccgc tggtcacccc
     6001 caccagccag atcgttggca cgcaggctgt gttcaacgtc atcatgggcg agcgctacaa
     6061 gatggttacc aaggagttca agggtctggt ccacggcgac tacggcaaga ctcccgctcc
     6121 catcaagccc gagttcacca agaagatcct tggcgacgag cagcccatta cctgccgctt
     6181 tgccgacacg ctggctcccg agatggacaa gctgaaggcc gaggctgcca agtgggcaac
     6241 gcaggaagag gacgtgctga cctacgctat gttcccgcag gtcgctccca agttcttcga
     6301 taagcgcaat gccaaaaagc agggcgtgga cggcgatcat gtggactaca ccaaccagtc
     6361 ccatcctgtc tgataaataa gtccctttca gggctgctgc acaaaatgct gtgcagcagc
     6421 cttttttgcg tatccggcaa aggcacaaga cgtactctgt cggccaatcc cggaaaaact
     6481 tctgcataca cattgacttg ccgcccaata ccttttataa tgtttggtat agccgtacaa
     6541 tacaacaaat gatgtggagg aaaatgctat gcgaagcatc ccggagcagc gcattgctga
     6601 gtttcaggag caggactatc aactgtattt tggcatttca aagctggaat ttgaccggat
     6661 gctcaaggct ctgcatgagg cttaccgtca ggagcataag cgcaagaccc gctttaccaa
     6721 gatctctatg atggataaac tcatcctgac cctgatctat cgctacgagt accgcacgat
     6781 ggaaagcatt gccaaggaat acgaggtttc tctggatacc attgccgaca acatccattg
     6841 ggtggagcgc acgctgctca atgcagatat cctgcaaacc agtgtgacct gcgtttataa
     6901 gacgaactga tgttatgacc ctgcgtgaaa acgcggggtt atatttttta caaggggaaa
     6961 acttctggaa aagcggtaac tgccgcagcc atgttgtttt ggctgcgcag cagtaaaaat
     7021 gaaaactgtg ttttttgcac ggatgcagtc tgcaccttga atttttcaga aaagaatagt
     7081 aaaatgatgc tatatgtatc gtaacatggg cttgtgtgcc caaagcggat acctatacag
     7141 aaaaaccgaa gttaaaccgc aaaagaatag gagctagtat gatcttaagc atgaccggtt
     7201 tcggcagggg aactgccgtg ctcaatggcc gtgagatcac tgtggaactg cgcagcgtga
     7261 actcccgcta tttcgagtat tcctcccgca tcccgcgcac ctgcagttct ctggacagcc
     7321 gcctgaaaaa gcagctcaac cagcggatct cccgcggcaa ggtagagctt agcatgaccg
     7381 tccagaacgt ggacgcagcg gataccgtgg tcgccgtcaa catggagctt gcccgcagct
     7441 atcagcaggc catgcgggac ctgtccgagc agctgggggt caaaaatgat gtgtccactg
     7501 ccgttctgac ccgcttcccg gatgtgctga ccacccgcca cgccgatgtg gacgaggagc
     7561 agctgtggca ggatgtgtct gccgtcaccg cgcaggcgct ggatcgcttt gtggagatgc
     7621 gtgccgccga gggcgccaag atgaaggcag acgtggaaag ccgtcttgtg tttctggagc
     7681 agtgcgtcgg caaagttgag agcctgagtg caggccgggt ggaaaactac accaaccgcc
     7741 tgtacgagaa actcaaggtc atcctgcagg atcgcgacat cgatgacgcc cgtgtgctga
     7801 ccgaagccgc catctttggc gataagactg ccgtggatga agaaactgtc cgtctgcgca
     7861 gccacattgc acagtaccgc gatatcctgc agctggacga gcccgtgggc cgcaagctgg
     7921 atttcctgac gcaggagttg aaccgtgaga ccaataccat cggctccaag tgtcaggatc
     7981 tggatatcac ccgtattgtg gtggatatga aggcggagat cgaaaaaatc cgcgagcaga
     8041 tccagaatct ggaataatat gttgtggagg agcctatgaa actcatcaac atcggctttg
     8101 gcaatatggt cagtgcgggg cgcgtggtgg cagtcgtcag cccggactcc gcaccggtca
     8161 aacgtctggt gaaggaagca cgcgagcgcg ggatgctgat cgatgcctct tacggccgca
     8221 gcacccgagc tgtgcttatc atggactccg atcatgtcgt gctgtccgcc cttcagcccg
     8281 aaacggtggc aagccgcgcc gccgggcagg agggtagagc atcaatggag gaagaaacat
     8341 ctcatggcga atgataaatt tctgtttgta gtttccggcg cagccggcac cggcaaggac
     8401 agcgtggtca aggcactgcg cgaggcacac cccgagatcg aaaagaccgt ctctgccacc
     8461 acacgcgccc cgcgccccgg cgagcaggag ggtgtggact actactaccg cacccgtgaa
     8521 cagttccagc agctgctgga aaacgatcag gtggtggagc acaacttcta taacggcaac
     8581 tactacggca ccctgaagtc tgaggtggaa aagcggctgg aagctggtaa ggtggtcgtg
     8641 ctggtcatcg atgtgcacgg cgctgccaat atccgccgga tgttcccggg cgctaccacc
     8701 gtgttcctgc tgccgccctc tgtggaggag ctggagcatc gcctgcgcgg ccgcggcacc
     8761 gagactgagg aaagcattca ggagcgtctc gccaccgccc ggcaggagct ggccgagcag
     8821 gataagttta ccgtaaagct ggtcaacaac cagatcgagc cctgcgctgc agagctttat
     8881 caggtcatct gtcagcgcgc cgggctgcag gagtgaaaaa tcaagcgttg aaggagttgg
     8941 acgaatgccc aaaacggtag gcgttgccgt cagcaatgcg accttccatt ttgataagct
     9001 gtatacctac gccgttctgc cggagcacca gaatgtggtg cgtctgggca gcatggtact
     9061 ggtacccttc ggcaagggta gccgcgcccg catgggtgtg gtactggcct gcgatgccga
     9121 gccggagtac tccaagctga aatatctgtt tgacgtagcc ccggcttcgg cctgcctgac
     9181 cccggagctg ctgcggctgg tgtatttttt aaaggaacgc accttctgca cctactacga
     9241 ggccgtcaag gcggtcattc cgtatggtgc gcagtataag cccgccgtgg cggcagacgg
     9301 tgtgaccccg gtgctgcaaa agcagcttac ccgtcacacc gaaaatgcct ataagcttgt
     9361 gggcactctg ccgcaaaagc caaagcctac ggcaaagcag ctggcggcgg tggcgctgct
     9421 gagcggcggt ccccgcaccc tgaacgaact ggaggataag ggcatcagcc gcgccgtgct
     9481 ggataacctg tgcaccaagg gtgtgctgga atgcagcaag gtgaataagt ccatcgacct
     9541 ctacgcctcc atcccgctgc gcaacgaccc catcaccctc acagagcagc agcaggccgc
     9601 ttacgacacg ctgctgccca aactagaaga taccgcaccc cattcggcgc tgttgtacgg
     9661 tgttaccggc agcggcaaga cgctggtgtt tttaaagttg atttcccgct gtctggaact
     9721 tggccgcaag gcgctggtgc tggtgccgga gatcagcctg accccgcaga tgatcctgcg
     9781 actcaaggga cagttcggcc gccgcgtggc ggtgcagcac tccgcgctca accacaccga
     9841 gcgtctgctg caatggcaga tgattcagga cggcggtgca gatatcgtgg tcggcacccg
     9901 cagcgcagtg ttttcgccgt tggaaaacat cggccttatc atcattgacg aggagcagga
     9961 gcacacctac cggtcggaat ccgcaccacg ctactctgcc cacgaggtcg cccggcagcg
    10021 tgccgccgaa aacggcgcac tactgcttct ggccagcgcc acccccagca ccgagagctt
    10081 ctacgctgca cagaacggac gcacccagct ggtgcgtctg accaagcgct atggcggcaa
    10141 cccgctgccc agtgtgcaga tcgtggatat gcgggcagag ctggctgcgg gcaacccccg
    10201 ggagatcagc cttgcgctgg aagatgccat ccgtcgcaat ctggaagcgg aaaagcagac
    10261 cattcttctg ctcaaccgcc ggggctacca gaccattgcc cagtgcgagg actgccgcga
    10321 ggtgctcaag tgccccaagt gcagcgtgcc catggtgtac cacaaatcag cgcataaggt
    10381 gctgtgccac tactgcggct cccagcagga gccgccgccc accctttgcc cggcctgcgg
    10441 cggcaagctg cagtaccggg gctttggtac ccagaaggcc gaggaggagc tggcaaagct
    10501 cttcccggag gcgcgggtgc tgcgcatgga tcaagactct accgccgcca aggacgccca
    10561 cgagaagctg cttgccaaat ttgcagcgca tgaatatgac atcatggtgg gtacccagat
    10621 ggtggcaaag ggacaggatc tcgaggatga gacccttgtg ggtgttctgg gcattgattc
    10681 gctgctgttt gcgcaaggct tccg
//
