## Tue Jul 2 07:07:12 2024 ## emapper-2.1.12 ## /d223NFS/m128030022/anaconda3/envs/eggnog/bin/emapper.py -i /d223NFS/m128030014/NGP/gene_list/prokka_results/GCA_021623275.1/GCA_021623275.1.faa --temp_dir /d223NFS/m128030022/NGPs/NGPs_new/databases/NGPs_DB/NGPs_db/GCA_021623275.1/2.eggNOGmapper --output_dir /d223NFS/m128030022/NGPs/NGPs_new/databases/NGPs_DB/NGPs_db/GCA_021623275.1/2.eggNOGmapper --output eggNOG_out --override --cpu 20 -m diamond --sensmode fast ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs LANLAPFM_00001 1256908.HMPREF0373_02866 3.38e-133 392.0 COG0194@1|root,COG4502@1|root,COG0194@2|Bacteria,COG4502@2|Bacteria,1V87A@1239|Firmicutes,24SD2@186801|Clostridia 186801|Clostridia F 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) - - - - - - - - - - - - Guanylate_kin,NT5C LANLAPFM_00002 411474.COPEUT_01787 0.0 992.0 COG1866@1|root,COG1866@2|Bacteria,1TPQV@1239|Firmicutes,248JE@186801|Clostridia 186801|Clostridia H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP LANLAPFM_00003 622312.ROSEINA2194_00966 3.95e-136 390.0 COG1684@1|root,COG1684@2|Bacteria,1TRB2@1239|Firmicutes,24ECW@186801|Clostridia 186801|Clostridia N flagellar biosynthetic protein FliR fliR - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 LANLAPFM_00004 585394.RHOM_07030 6.88e-46 149.0 COG1987@1|root,COG1987@2|Bacteria,1VEHF@1239|Firmicutes,24QJR@186801|Clostridia 186801|Clostridia N Flagellar biosynthetic protein FliQ fliQ - - ko:K02420 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_3 LANLAPFM_00005 585394.RHOM_07025 1.41e-115 340.0 COG1338@1|root,COG1338@2|Bacteria,1TPIE@1239|Firmicutes,2487C@186801|Clostridia 186801|Clostridia N Plays a role in the flagellum-specific transport system fliP - - ko:K02419 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliP LANLAPFM_00007 585394.RHOM_09240 2.92e-45 148.0 2DP3R@1|root,330E2@2|Bacteria,1VEPT@1239|Firmicutes,24QJB@186801|Clostridia 186801|Clostridia S COG NOG16856 non supervised orthologous group - - - - - - - - - - - - DUF1540 LANLAPFM_00008 585394.RHOM_09230 5.85e-87 261.0 2C6U1@1|root,30XIE@2|Bacteria,1V4EP@1239|Firmicutes,24J3E@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Zn_dep_PLPC LANLAPFM_00011 585394.RHOM_09220 1.49e-93 273.0 COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,24HB9@186801|Clostridia 186801|Clostridia K Belongs to the MraZ family mraZ - - ko:K03925 - - - - ko00000 - - - MraZ LANLAPFM_00012 622312.ROSEINA2194_01247 3.2e-196 547.0 COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia 186801|Clostridia J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 LANLAPFM_00013 622312.ROSEINA2194_01246 4.57e-60 191.0 2E3U8@1|root,32YRK@2|Bacteria,1VEYB@1239|Firmicutes,24QRX@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - DivIC LANLAPFM_00014 585394.RHOM_09205 0.0 1048.0 COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia 186801|Clostridia M penicillin-binding protein - - - ko:K08384 ko00550,map00550 - - - ko00000,ko00001,ko01011 - - - PBP_dimer,Transpeptidase LANLAPFM_00015 585394.RHOM_09200 0.0 935.0 COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia 186801|Clostridia M penicillin-binding protein spoVD - 3.4.16.4 ko:K03587,ko:K08384 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase LANLAPFM_00016 585394.RHOM_09195 1.71e-198 553.0 COG0472@1|root,COG0472@2|Bacteria,1TP8W@1239|Firmicutes,247S7@186801|Clostridia 186801|Clostridia M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 LANLAPFM_00017 585394.RHOM_09190 3.3e-192 548.0 COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,248GS@186801|Clostridia 186801|Clostridia M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M LANLAPFM_00018 585394.RHOM_09185 4.55e-203 569.0 COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia 186801|Clostridia D Belongs to the SEDS family ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE LANLAPFM_00019 585394.RHOM_09180 7.63e-120 348.0 COG1589@1|root,COG1589@2|Bacteria,1V34X@1239|Firmicutes,248RF@186801|Clostridia 186801|Clostridia M COG1589 Cell division septal protein - - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 LANLAPFM_00020 585394.RHOM_09175 1.55e-231 643.0 COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia 186801|Clostridia D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin LANLAPFM_00021 742741.HMPREF9475_01248 2.49e-11 68.6 29ECG@1|root,301AF@2|Bacteria,1UY4W@1239|Firmicutes,24HI3@186801|Clostridia,21YX0@1506553|Lachnoclostridium 186801|Clostridia M aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR spoIIGA - - ko:K06383 - - - - ko00000,ko01000,ko01002 - - - Peptidase_U4 LANLAPFM_00022 585394.RHOM_09165 6.64e-130 374.0 COG1191@1|root,COG1191@2|Bacteria,1TP3T@1239|Firmicutes,24A4T@186801|Clostridia 186801|Clostridia K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released sigE - - ko:K03091 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4 LANLAPFM_00023 585394.RHOM_16625 0.0 1115.0 COG3887@1|root,COG3887@2|Bacteria,1TPGP@1239|Firmicutes,2484R@186801|Clostridia 186801|Clostridia T domain protein yybT - - - - - - - - - - - DHH,DHHA1 LANLAPFM_00024 622312.ROSEINA2194_04348 1.72e-38 140.0 COG3187@1|root,COG3187@2|Bacteria,1UMA9@1239|Firmicutes,25GDD@186801|Clostridia 186801|Clostridia O Heat shock protein - - - - - - - - - - - - - LANLAPFM_00025 1235793.C809_00094 2.17e-170 482.0 COG0524@1|root,COG0524@2|Bacteria,1TPGM@1239|Firmicutes,247M1@186801|Clostridia,27IAP@186928|unclassified Lachnospiraceae 186801|Clostridia G pfkB family carbohydrate kinase - - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB LANLAPFM_00026 97139.C824_01915 1.26e-171 508.0 COG3345@1|root,COG3345@2|Bacteria,1TQF4@1239|Firmicutes,2489F@186801|Clostridia,36EIY@31979|Clostridiaceae 186801|Clostridia G alpha-galactosidase - - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Glyco_hydro_36C,Glyco_hydro_36N,Melibiase LANLAPFM_00027 1298920.KI911353_gene656 6.07e-276 769.0 COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia,21XQ0@1506553|Lachnoclostridium 186801|Clostridia G SMART alpha amylase catalytic sub domain malL - 3.2.1.1,3.2.1.10 ko:K01176,ko:K01182 ko00052,ko00500,ko01100,ko04973,map00052,map00500,map01100,map04973 - R00801,R01718,R01791,R02108,R02112,R06199,R11262 RC00028,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C LANLAPFM_00028 1449050.JNLE01000003_gene575 2.05e-172 488.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,36F5I@31979|Clostridiaceae 186801|Clostridia K Transcriptional regulator, LacI family - - - ko:K02529,ko:K03484 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 LANLAPFM_00029 1235793.C809_00086 2.46e-162 479.0 COG1621@1|root,COG1621@2|Bacteria,1TPAE@1239|Firmicutes,247UU@186801|Clostridia,27J9G@186928|unclassified Lachnospiraceae 186801|Clostridia G Glycosyl hydrolases family 32 - - 3.2.1.80 ko:K03332 ko00051,map00051 - R00879 - ko00000,ko00001,ko01000 - - - Big_2,CW_binding_1,Cadherin-like,DUF1080,Flg_new,Glyco_hydro_32C,Glyco_hydro_32N LANLAPFM_00030 1408324.JNJK01000020_gene3670 9.42e-47 165.0 COG2182@1|root,COG2182@2|Bacteria,1UIC9@1239|Firmicutes,2499Z@186801|Clostridia,27KJ5@186928|unclassified Lachnospiraceae 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_8 LANLAPFM_00031 397291.C804_04832 4.27e-266 824.0 COG3209@1|root,COG3693@1|root,COG5492@1|root,COG3209@2|Bacteria,COG3693@2|Bacteria,COG5492@2|Bacteria,1UHTC@1239|Firmicutes,248KD@186801|Clostridia,27K6N@186928|unclassified Lachnospiraceae 186801|Clostridia G Carbohydrate family 9 binding domain-like - - 3.2.1.4,3.2.1.8 ko:K01179,ko:K01181 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM9_1,CBM_4_9,Glyco_hydro_10,Polysacc_deac_1,SLH LANLAPFM_00032 180332.JTGN01000009_gene4214 1.5e-43 162.0 COG3533@1|root,COG5492@1|root,COG3533@2|Bacteria,COG5492@2|Bacteria,1VTDU@1239|Firmicutes 1239|Firmicutes N Bacterial Ig-like domain (group 4) - - - - - - - - - - - - Beta_helix,Big_2,Big_4 LANLAPFM_00033 585394.RHOM_16635 1.51e-57 178.0 COG0238@1|root,COG0238@2|Bacteria,1V9XS@1239|Firmicutes,24MQV@186801|Clostridia 186801|Clostridia J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 LANLAPFM_00034 585394.RHOM_16640 8.85e-97 282.0 COG0629@1|root,COG0629@2|Bacteria,1V3WT@1239|Firmicutes,24HF9@186801|Clostridia 186801|Clostridia L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB LANLAPFM_00035 585394.RHOM_16645 4.62e-54 170.0 COG0360@1|root,COG0360@2|Bacteria,1VA18@1239|Firmicutes,24QZQ@186801|Clostridia 186801|Clostridia J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 LANLAPFM_00036 622312.ROSEINA2194_04343 1.32e-33 116.0 COG4481@1|root,COG4481@2|Bacteria,1VEQ7@1239|Firmicutes,24QKA@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF951 LANLAPFM_00037 1123075.AUDP01000021_gene1398 9.08e-83 247.0 COG4894@1|root,COG4894@2|Bacteria,1V3WA@1239|Firmicutes,24MB0@186801|Clostridia,3WJCK@541000|Ruminococcaceae 186801|Clostridia S LURP-one-related - - - - - - - - - - - - LOR LANLAPFM_00038 585394.RHOM_16655 1.52e-156 441.0 COG0846@1|root,COG0846@2|Bacteria,1TQKD@1239|Firmicutes,2491J@186801|Clostridia 186801|Clostridia K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 LANLAPFM_00039 483218.BACPEC_02910 7.56e-149 447.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,268D0@186813|unclassified Clostridiales 186801|Clostridia NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,dCache_1 LANLAPFM_00041 585394.RHOM_16660 2.33e-84 253.0 COG0700@1|root,COG0700@2|Bacteria,1V45M@1239|Firmicutes,24HSJ@186801|Clostridia 186801|Clostridia S PFAM nucleoside recognition domain protein spmB - - ko:K06374 - - - - ko00000 - - - Gate LANLAPFM_00042 622312.ROSEINA2194_04339 7.24e-231 654.0 COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,1TS8B@1239|Firmicutes,24EZ4@186801|Clostridia 186801|Clostridia T GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_3,Response_reg LANLAPFM_00043 585394.RHOM_16670 4.05e-104 305.0 COG2715@1|root,COG2715@2|Bacteria,1V1E2@1239|Firmicutes,249G0@186801|Clostridia 186801|Clostridia S membrane protein required for spore maturation spmA - - ko:K06373 - - - - ko00000 - - - Gate LANLAPFM_00044 585394.RHOM_16680 3.85e-235 669.0 COG4805@1|root,COG4805@2|Bacteria,1TREN@1239|Firmicutes,249U9@186801|Clostridia 186801|Clostridia S protein conserved in bacteria - - - - - - - - - - - - DUF885 LANLAPFM_00045 622312.ROSEINA2194_04330 9.73e-173 485.0 COG0313@1|root,COG0313@2|Bacteria,1TP6U@1239|Firmicutes,24864@186801|Clostridia 186801|Clostridia H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase LANLAPFM_00046 642492.Clole_0437 3.32e-153 435.0 COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia 186801|Clostridia P ABC-type nitrate sulfonate bicarbonate transport system ATPase component - - - ko:K02049,ko:K15555 ko00920,ko02010,map00920,map02010 M00188,M00436 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16,3.A.1.17,3.A.1.17.2 - - ABC_tran LANLAPFM_00047 642492.Clole_0436 2.66e-134 386.0 COG0600@1|root,COG0600@2|Bacteria,1UYCY@1239|Firmicutes,249RH@186801|Clostridia 186801|Clostridia P PFAM Binding-protein-dependent transport system inner membrane component - - - ko:K02050,ko:K15552 ko00920,ko02010,map00920,map02010 M00188,M00435 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.17,3.A.1.17.1,3.A.1.17.4 - - BPD_transp_1 LANLAPFM_00048 642492.Clole_0435 2.32e-166 475.0 COG0715@1|root,COG0715@2|Bacteria,1UYBA@1239|Firmicutes,24D4Q@186801|Clostridia 186801|Clostridia P TIGRFAM ABC transporter, substrate-binding protein, aliphatic - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,OmpA LANLAPFM_00049 642492.Clole_0434 3.99e-54 171.0 COG0347@1|root,COG0347@2|Bacteria,1V73J@1239|Firmicutes,24S5C@186801|Clostridia 186801|Clostridia K Belongs to the P(II) protein family - - - ko:K02590 - - - - ko00000 - - - P-II LANLAPFM_00050 642492.Clole_0433 2.32e-49 159.0 COG0347@1|root,COG0347@2|Bacteria,1VASB@1239|Firmicutes,24J84@186801|Clostridia 186801|Clostridia K Belongs to the P(II) protein family - - - ko:K02589 - - - - ko00000 - - - P-II LANLAPFM_00051 642492.Clole_0432 6e-282 785.0 COG0154@1|root,COG0154@2|Bacteria,1TSAQ@1239|Firmicutes,2483V@186801|Clostridia 186801|Clostridia J PFAM Amidase - - 3.5.1.54 ko:K01457 ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120 - R00005 RC02756 ko00000,ko00001,ko01000 - - - Amidase LANLAPFM_00052 642492.Clole_0431 0.0 1904.0 COG0439@1|root,COG1984@1|root,COG2049@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,1TPUN@1239|Firmicutes,24E9Y@186801|Clostridia 186801|Clostridia EI Allophanate hydrolase subunit 1 - - 6.3.4.6 ko:K01941 ko00220,ko00791,ko01100,map00220,map00791,map01100 - R00774 RC00378 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D LANLAPFM_00053 642492.Clole_0430 1.22e-139 396.0 COG3665@1|root,COG3665@2|Bacteria,1UYE1@1239|Firmicutes,24DNP@186801|Clostridia 186801|Clostridia S TIGRFAM Urea carboxylase-associated protein 1 - - - ko:K09967 - - - - ko00000 - - - DUF1989 LANLAPFM_00054 642492.Clole_0429 5.54e-156 439.0 COG3665@1|root,COG3665@2|Bacteria,1TQQF@1239|Firmicutes,24DHT@186801|Clostridia 186801|Clostridia S TIGRFAM Urea carboxylase-associated protein 2 - - - ko:K09967 - - - - ko00000 - - - DUF1989 LANLAPFM_00055 642492.Clole_0428 1.6e-79 247.0 COG2197@1|root,COG2197@2|Bacteria,1V7ZQ@1239|Firmicutes,25BMW@186801|Clostridia 186801|Clostridia K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE LANLAPFM_00056 1122915.AUGY01000071_gene4411 1.28e-40 149.0 COG0715@1|root,COG0715@2|Bacteria,1UY07@1239|Firmicutes,4HCR6@91061|Bacilli,26S7G@186822|Paenibacillaceae 91061|Bacilli P NMT1-like family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 LANLAPFM_00057 1123257.AUFV01000001_gene1768 2.24e-36 130.0 COG1335@1|root,COG1335@2|Bacteria 2|Bacteria Q hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides - - - - - - - - - - - - Isochorismatase LANLAPFM_00058 457421.CBFG_03614 2.93e-19 88.2 COG2197@1|root,COG2197@2|Bacteria,1V7ZQ@1239|Firmicutes,25BMW@186801|Clostridia 186801|Clostridia K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE LANLAPFM_00059 622312.ROSEINA2194_00855 9.51e-23 88.2 2EJZ9@1|root,33DPV@2|Bacteria,1VQST@1239|Firmicutes,254M5@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00060 397290.C810_01918 4.97e-106 320.0 COG5492@1|root,COG5492@2|Bacteria,1V4A5@1239|Firmicutes,24IM0@186801|Clostridia,27MBH@186928|unclassified Lachnospiraceae 186801|Clostridia N Bacterial Ig-like domain 2 - - - - - - - - - - - - Big_2 LANLAPFM_00061 1414720.CBYM010000015_gene2999 1.8e-119 349.0 COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,36DPF@31979|Clostridiaceae 186801|Clostridia HP ABC transporter fhuC - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran LANLAPFM_00062 1414720.CBYM010000015_gene3000 1.23e-137 400.0 COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,24BGM@186801|Clostridia,36EF1@31979|Clostridiaceae 186801|Clostridia P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily fhuG - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD LANLAPFM_00063 1216932.CM240_2981 3.68e-139 404.0 COG0609@1|root,COG0609@2|Bacteria,1TP13@1239|Firmicutes,24A8W@186801|Clostridia,36FH9@31979|Clostridiaceae 186801|Clostridia P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily fhuB - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD LANLAPFM_00064 1499683.CCFF01000013_gene228 9.43e-160 456.0 COG0614@1|root,COG0614@2|Bacteria,1TQMK@1239|Firmicutes,24B1M@186801|Clostridia,36EU7@31979|Clostridiaceae 186801|Clostridia P Periplasmic binding protein fhuD - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 LANLAPFM_00065 290402.Cbei_2136 4.59e-91 283.0 COG2207@1|root,COG2207@2|Bacteria,1V0EE@1239|Firmicutes,25B24@186801|Clostridia,36FJY@31979|Clostridiaceae 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 LANLAPFM_00066 585394.RHOM_16690 3.76e-144 410.0 COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24BK7@186801|Clostridia 186801|Clostridia M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT LANLAPFM_00067 622312.ROSEINA2194_04328 4.33e-155 437.0 COG4123@1|root,COG4123@2|Bacteria,1TQ25@1239|Firmicutes,249UH@186801|Clostridia 186801|Clostridia S Methyltransferase yfiC - 2.1.1.223 ko:K15460 - - - - ko00000,ko01000,ko03016 - - - MTS,Methyltransf_31 LANLAPFM_00068 622312.ROSEINA2194_04327 2.14e-187 524.0 COG1774@1|root,COG1774@2|Bacteria,1TP1V@1239|Firmicutes,247Q6@186801|Clostridia 186801|Clostridia K domain protein yaaT - - - - - - - - - - - PSP1 LANLAPFM_00069 622312.ROSEINA2194_04326 9.47e-198 553.0 COG2812@1|root,COG2812@2|Bacteria,1VCQC@1239|Firmicutes,248U4@186801|Clostridia 186801|Clostridia L 'dna polymerase iii holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C LANLAPFM_00070 622312.ROSEINA2194_04325 4.89e-82 244.0 COG1728@1|root,COG1728@2|Bacteria,1VF6M@1239|Firmicutes,24S6C@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF327) - - - ko:K09770 - - - - ko00000 - - - DUF327 LANLAPFM_00071 622312.ROSEINA2194_04324 1.47e-96 286.0 COG0194@1|root,COG0194@2|Bacteria,1V3RZ@1239|Firmicutes,24HKC@186801|Clostridia 186801|Clostridia F Psort location Cytoplasmic, score gmk_1 - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin LANLAPFM_00072 622312.ROSEINA2194_04323 2.77e-208 593.0 COG1982@1|root,COG1982@2|Bacteria,1TNZ9@1239|Firmicutes,247RA@186801|Clostridia 186801|Clostridia E Orn Lys Arg decarboxylase major speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - OKR_DC_1,OKR_DC_1_C LANLAPFM_00073 622312.ROSEINA2194_04322 3.71e-96 293.0 COG0746@1|root,COG0746@2|Bacteria 2|Bacteria H molybdenum cofactor guanylyltransferase activity mobA GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.77 ko:K03752,ko:K13818 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - DUF3305,NTP_transf_3 LANLAPFM_00074 585394.RHOM_16730 1.8e-72 232.0 2EE0F@1|root,337V8@2|Bacteria,1VFWV@1239|Firmicutes,24SC3@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00075 585394.RHOM_16735 2.65e-112 327.0 COG5340@1|root,COG5340@2|Bacteria,1USGA@1239|Firmicutes,24IEV@186801|Clostridia 186801|Clostridia K Transcriptional regulator, AbiEi antitoxin - - - - - - - - - - - - AbiEi_4 LANLAPFM_00076 585394.RHOM_16745 7.3e-209 591.0 COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia 186801|Clostridia M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K01286,ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 LANLAPFM_00077 585394.RHOM_06360 1.92e-268 769.0 COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,1TS8B@1239|Firmicutes,24EZ4@186801|Clostridia 186801|Clostridia T GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_3,Response_reg LANLAPFM_00078 642492.Clole_1639 1.3e-304 855.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia 186801|Clostridia G hydrolase, family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C LANLAPFM_00079 357809.Cphy_0218 0.0 1185.0 COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,24A10@186801|Clostridia,21YQ6@1506553|Lachnoclostridium 186801|Clostridia G Galactose mutarotase-like - - 3.2.1.177 ko:K01811 - - - - ko00000,ko01000 - GH31 - DUF4968,Gal_mutarotas_2,Glyco_hydro_31 LANLAPFM_00080 1195236.CTER_3491 2.28e-204 584.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V4UB@1239|Firmicutes,24BJM@186801|Clostridia,3WRKI@541000|Ruminococcaceae 186801|Clostridia K PFAM response regulator receiver - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,Response_reg LANLAPFM_00081 1469948.JPNB01000001_gene966 0.0 889.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36E82@31979|Clostridiaceae 186801|Clostridia V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_00082 1469948.JPNB01000001_gene965 3.7e-308 853.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36DEY@31979|Clostridiaceae 186801|Clostridia V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_00083 180332.JTGN01000001_gene4817 3.22e-97 294.0 COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1V2EN@1239|Firmicutes,24GG9@186801|Clostridia 186801|Clostridia K PFAM helix-turn-helix- domain containing protein AraC type - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18 LANLAPFM_00084 689781.AUJX01000061_gene567 3.41e-260 721.0 COG1373@1|root,COG1373@2|Bacteria,1TQ8Z@1239|Firmicutes,24BKQ@186801|Clostridia,2PRAW@265975|Oribacterium 186801|Clostridia S Domain of unknown function (DUF4143) - - - - - - - - - - - - AAA_14,DUF4143 LANLAPFM_00085 411460.RUMTOR_01909 3.57e-31 112.0 COG3070@1|root,COG3070@2|Bacteria,1V42M@1239|Firmicutes,24JNV@186801|Clostridia,3Y06Z@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - TfoX_N LANLAPFM_00086 1408311.JNJM01000002_gene1192 2.22e-75 226.0 29A02@1|root,2ZX1N@2|Bacteria,1V48B@1239|Firmicutes,24HF1@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00087 1069534.LRC_05120 1.68e-86 258.0 COG4283@1|root,COG4283@2|Bacteria,1V8M5@1239|Firmicutes,4HHMT@91061|Bacilli,3F6RT@33958|Lactobacillaceae 91061|Bacilli S DinB superfamily - - - - - - - - - - - - DUF1706 LANLAPFM_00088 585394.RHOM_14450 9.26e-109 315.0 COG0203@1|root,COG0203@2|Bacteria,1V6JQ@1239|Firmicutes,24J9T@186801|Clostridia 186801|Clostridia J ribosomal protein l17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 LANLAPFM_00089 585394.RHOM_14460 8.48e-216 597.0 COG0202@1|root,COG0202@2|Bacteria,1TPR8@1239|Firmicutes,248DS@186801|Clostridia 186801|Clostridia K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L LANLAPFM_00090 585394.RHOM_14465 1.58e-132 376.0 COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia 186801|Clostridia J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 LANLAPFM_00091 622312.ROSEINA2194_02078 1.22e-74 224.0 COG0100@1|root,COG0100@2|Bacteria,1V3IK@1239|Firmicutes,24HIK@186801|Clostridia 186801|Clostridia J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 LANLAPFM_00092 585394.RHOM_14475 3.76e-72 218.0 COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,24HCT@186801|Clostridia 186801|Clostridia J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 LANLAPFM_00093 585394.RHOM_14490 6.91e-45 145.0 COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,24MQE@186801|Clostridia 186801|Clostridia J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a LANLAPFM_00094 397288.C806_00699 1.21e-18 80.1 COG2163@1|root,COG2163@2|Bacteria,1VEPA@1239|Firmicutes,24UP0@186801|Clostridia 186801|Clostridia J COG2163 Ribosomal protein L14E L6E L27E - - - - - - - - - - - - - LANLAPFM_00095 585394.RHOM_14500 2.38e-154 437.0 COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia 186801|Clostridia E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 LANLAPFM_00096 622312.ROSEINA2194_02071 1.63e-147 416.0 COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia 186801|Clostridia F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - iHN637.CLJU_RS20110 ADK,ADK_lid LANLAPFM_00097 585394.RHOM_14510 3.47e-276 760.0 COG0201@1|root,COG0201@2|Bacteria,1TPHB@1239|Firmicutes,248T9@186801|Clostridia 186801|Clostridia U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY LANLAPFM_00098 622312.ROSEINA2194_02069 1.42e-92 271.0 COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,24HAJ@186801|Clostridia 186801|Clostridia J Binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A LANLAPFM_00099 585394.RHOM_14520 3.04e-32 112.0 COG1841@1|root,COG1841@2|Bacteria 2|Bacteria J maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rpmD GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 LANLAPFM_00100 585394.RHOM_14525 1.84e-106 308.0 COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,24G5D@186801|Clostridia 186801|Clostridia J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C LANLAPFM_00101 622312.ROSEINA2194_02066 6.5e-73 219.0 COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,24JCS@186801|Clostridia 186801|Clostridia J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p LANLAPFM_00102 585394.RHOM_14535 7.41e-120 343.0 COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,2496R@186801|Clostridia 186801|Clostridia J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 LANLAPFM_00103 585394.RHOM_14545 2.87e-88 259.0 COG0096@1|root,COG0096@2|Bacteria,1V3KK@1239|Firmicutes,24HCP@186801|Clostridia 186801|Clostridia J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 LANLAPFM_00104 585394.RHOM_14550 4.1e-39 129.0 COG0199@1|root,COG0199@2|Bacteria,1VEF6@1239|Firmicutes,24QR1@186801|Clostridia 186801|Clostridia J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 LANLAPFM_00105 585394.RHOM_14555 9.01e-121 345.0 COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,247X0@186801|Clostridia 186801|Clostridia J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C LANLAPFM_00106 1235790.C805_00242 7.38e-61 187.0 COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,24MY0@186801|Clostridia,25WQ0@186806|Eubacteriaceae 186801|Clostridia J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 LANLAPFM_00107 585394.RHOM_14565 2.87e-76 228.0 COG0093@1|root,COG0093@2|Bacteria,1V3N0@1239|Firmicutes,24H98@186801|Clostridia 186801|Clostridia J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 LANLAPFM_00108 622312.ROSEINA2194_02060 3.48e-53 167.0 COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia 186801|Clostridia J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 LANLAPFM_00109 585394.RHOM_14575 5.47e-34 117.0 COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,24QV1@186801|Clostridia 186801|Clostridia J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 LANLAPFM_00110 622312.ROSEINA2194_02058 2.11e-98 286.0 COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,24FQX@186801|Clostridia 186801|Clostridia J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 LANLAPFM_00111 585394.RHOM_14585 1.69e-151 426.0 COG0092@1|root,COG0092@2|Bacteria,1TPCP@1239|Firmicutes,24833@186801|Clostridia 186801|Clostridia J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C LANLAPFM_00115 585394.RHOM_03675 1.56e-84 253.0 2ANER@1|root,31DDD@2|Bacteria,1V46U@1239|Firmicutes,24JDI@186801|Clostridia 186801|Clostridia S stage V sporulation protein AC spoVAC - - ko:K06405 - - - - ko00000 - - - SpoVAC_SpoVAEB LANLAPFM_00117 59374.Fisuc_1259 1.79e-10 65.5 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria 2|Bacteria T PhoQ Sensor - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,Response_reg LANLAPFM_00119 622312.ROSEINA2194_03062 2.72e-224 621.0 COG0371@1|root,COG0371@2|Bacteria,1TR6W@1239|Firmicutes,25CDJ@186801|Clostridia 186801|Clostridia C 3-dehydroquinate synthase egsA - 1.1.1.261 ko:K00096 ko00564,map00564 - R05679,R05680 RC00029 ko00000,ko00001,ko01000 - - - Fe-ADH_2 LANLAPFM_00121 585394.RHOM_10215 0.0 972.0 COG0369@1|root,COG1151@2|Bacteria,1TP8X@1239|Firmicutes,247IN@186801|Clostridia 186801|Clostridia C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O hcp - 1.7.99.1 ko:K05601 ko00910,map00910 - R00143 RC02797 ko00000,ko00001,ko01000 - - - Prismane LANLAPFM_00122 585394.RHOM_03700 3.56e-142 406.0 COG0561@1|root,COG0561@2|Bacteria,1V1JB@1239|Firmicutes,24AY8@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Hydrolase_3 LANLAPFM_00123 622312.ROSEINA2194_01879 3.88e-73 222.0 2E3N2@1|root,32YK7@2|Bacteria,1VEYM@1239|Firmicutes,24QJ0@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00124 1280698.AUJS01000100_gene153 4.33e-127 364.0 COG2039@1|root,COG2039@2|Bacteria,1TRRX@1239|Firmicutes,248T4@186801|Clostridia,27W6C@189330|Dorea 186801|Clostridia O Pyroglutamyl peptidase pcp - 3.4.19.3 ko:K01304 - - - - ko00000,ko01000,ko01002 - - - Peptidase_C15 LANLAPFM_00125 585394.RHOM_03705 2.78e-90 294.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3,HlyD_D23 LANLAPFM_00126 585394.RHOM_03710 1.36e-135 407.0 COG0845@1|root,COG0845@2|Bacteria,1V96V@1239|Firmicutes,24BEV@186801|Clostridia 186801|Clostridia M Efflux transporter, RND family, MFP subunit - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 LANLAPFM_00127 585394.RHOM_03715 1.91e-219 620.0 COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,24AWU@186801|Clostridia 186801|Clostridia V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD LANLAPFM_00129 585394.RHOM_03725 6.18e-130 374.0 COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia 186801|Clostridia V ABC transporter lolD - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran LANLAPFM_00130 585394.RHOM_03730 3.4e-116 338.0 COG4912@1|root,COG4912@2|Bacteria,1TQII@1239|Firmicutes,248N8@186801|Clostridia 186801|Clostridia L Psort location Cytoplasmic, score - - - - - - - - - - - - DNA_alkylation LANLAPFM_00131 411902.CLOBOL_06104 2.98e-113 333.0 COG0483@1|root,COG0483@2|Bacteria,1TR4E@1239|Firmicutes,24KJZ@186801|Clostridia,22041@1506553|Lachnoclostridium 186801|Clostridia G Inositol monophosphatase family - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P LANLAPFM_00132 585394.RHOM_14180 0.0 1023.0 COG1368@1|root,COG1368@2|Bacteria,1TRMA@1239|Firmicutes,2480C@186801|Clostridia 186801|Clostridia M PFAM sulfatase - - - - - - - - - - - - Sulfatase LANLAPFM_00133 585394.RHOM_14175 5.23e-233 642.0 COG1453@1|root,COG1453@2|Bacteria,1TSTA@1239|Firmicutes,249IP@186801|Clostridia 186801|Clostridia C aldo keto reductase - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red,Fer4_17 LANLAPFM_00134 622312.ROSEINA2194_04026 3.79e-104 306.0 COG0546@1|root,COG0546@2|Bacteria,1V3YI@1239|Firmicutes,24CRF@186801|Clostridia 186801|Clostridia C Psort location Cytoplasmic, score - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 LANLAPFM_00136 411459.RUMOBE_02462 2.05e-147 420.0 COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,3Y0BE@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K06864 - - - - ko00000 - - - ATP_bind_3,NAD_synthase,QueC LANLAPFM_00137 411462.DORLON_01513 2.59e-156 441.0 COG1179@1|root,COG1179@2|Bacteria,1TQ7A@1239|Firmicutes,248RA@186801|Clostridia,27VIT@189330|Dorea 186801|Clostridia H COG COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and THIamine biosynthesis family 1 thiF - - ko:K22132 - - - - ko00000,ko03016 - - - ThiF LANLAPFM_00138 1235793.C809_00892 0.0 936.0 COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia,27JM8@186928|unclassified Lachnospiraceae 186801|Clostridia E Bacterial extracellular solute-binding proteins, family 5 Middle oppA - - ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - SBP_bac_5 LANLAPFM_00139 1235793.C809_00893 2.47e-188 527.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,27KXN@186928|unclassified Lachnospiraceae 186801|Clostridia EP Binding-protein-dependent transport system inner membrane component oppB - - ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1 LANLAPFM_00140 1235793.C809_00894 8.03e-217 602.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,27II5@186928|unclassified Lachnospiraceae 186801|Clostridia EP N-terminal TM domain of oligopeptide transport permease C oppC - - ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1,OppC_N LANLAPFM_00141 1235793.C809_00895 9.68e-235 649.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,27JHK@186928|unclassified Lachnospiraceae 186801|Clostridia P Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY LANLAPFM_00142 748224.HMPREF9436_00019 3.18e-193 539.0 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,3WN2S@541000|Ruminococcaceae 186801|Clostridia P Oligopeptide/dipeptide transporter, C-terminal region oppF - - ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY LANLAPFM_00143 511680.BUTYVIB_00626 1.8e-149 449.0 COG0840@1|root,COG5000@1|root,COG0840@2|Bacteria,COG5000@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,4BX8J@830|Butyrivibrio 186801|Clostridia NT Methyl-accepting chemotaxis protein signaling domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal LANLAPFM_00144 622312.ROSEINA2194_01501 0.0 1144.0 COG0366@1|root,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 13 family tvaI - - - - - - - - - - - Alpha-amylase,Alpha-amylase_C,Alpha-amylase_N LANLAPFM_00146 2325.TKV_c09470 1.77e-24 103.0 COG2091@1|root,COG2091@2|Bacteria,1VEYZ@1239|Firmicutes,24RQ3@186801|Clostridia,42GYT@68295|Thermoanaerobacterales 186801|Clostridia H Belongs to the P-Pant transferase superfamily sfp - - ko:K06133 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS LANLAPFM_00147 585394.RHOM_06375 5.92e-102 296.0 COG0782@1|root,COG0782@2|Bacteria,1V1G3@1239|Firmicutes,24FRJ@186801|Clostridia 186801|Clostridia K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA_2 - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N LANLAPFM_00148 585394.RHOM_06380 5.43e-179 501.0 COG0685@1|root,COG0685@2|Bacteria,1TQFE@1239|Firmicutes,247ZK@186801|Clostridia 186801|Clostridia E 5,10-methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR LANLAPFM_00149 622312.ROSEINA2194_02781 1.74e-56 181.0 2EF5Q@1|root,338YV@2|Bacteria,1VJS5@1239|Firmicutes,24RWV@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00150 585394.RHOM_13440 7.58e-160 453.0 28KEH@1|root,2ZA0R@2|Bacteria,1V76J@1239|Firmicutes,24JHU@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF4300) - - - - - - - - - - - - DUF4300 LANLAPFM_00151 411461.DORFOR_03149 1.82e-98 298.0 COG0526@1|root,COG0526@2|Bacteria,1UY9A@1239|Firmicutes,24C03@186801|Clostridia,27WII@189330|Dorea 186801|Clostridia M COG COG0526 Thiol-disulfide isomerase and THIoredoxins - - - - - - - - - - - - AhpC-TSA,Redoxin LANLAPFM_00152 1256908.HMPREF0373_00304 5.08e-189 528.0 COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,25V01@186806|Eubacteriaceae 186801|Clostridia C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_5 LANLAPFM_00153 411474.COPEUT_01943 8.25e-138 392.0 COG0745@1|root,COG0745@2|Bacteria,1TSRR@1239|Firmicutes,24AG3@186801|Clostridia 186801|Clostridia T Psort location Cytoplasmic, score cutR - - - - - - - - - - - Response_reg,Trans_reg_C LANLAPFM_00154 411489.CLOL250_00372 3.28e-231 641.0 COG0642@1|root,COG2205@2|Bacteria,1UHQC@1239|Firmicutes,2496X@186801|Clostridia,36HCI@31979|Clostridiaceae 186801|Clostridia T Signal transduction histidine kinase arlS - - - - - - - - - - - HAMP,HATPase_c,HisKA LANLAPFM_00155 397288.C806_04417 1.02e-08 58.2 COG1132@1|root,COG1132@2|Bacteria,1US0C@1239|Firmicutes,24EZJ@186801|Clostridia,27M01@186928|unclassified Lachnospiraceae 186801|Clostridia V ABC transporter - - - - - - - - - - - - ABC_tran LANLAPFM_00156 622312.ROSEINA2194_00222 4.74e-175 489.0 COG0351@1|root,COG0351@2|Bacteria,1TQ4A@1239|Firmicutes,2483H@186801|Clostridia 186801|Clostridia H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin LANLAPFM_00157 585394.RHOM_13420 1.38e-246 681.0 COG1457@1|root,COG1457@2|Bacteria,1TTBN@1239|Firmicutes,248EP@186801|Clostridia 186801|Clostridia F PFAM Permease for cytosine purines, uracil, thiamine, allantoin cytX - - - - - - - - - - - Transp_cyt_pur LANLAPFM_00158 585394.RHOM_13415 1.3e-111 321.0 COG4732@1|root,COG4732@2|Bacteria,1V6HH@1239|Firmicutes,24JF7@186801|Clostridia 186801|Clostridia S ThiW protein thiW - - - - - - - - - - - ThiW LANLAPFM_00159 471875.RUMLAC_00916 6.1e-101 293.0 COG0454@1|root,COG0456@2|Bacteria,1V77V@1239|Firmicutes,24HI8@186801|Clostridia,3WIP1@541000|Ruminococcaceae 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - Acetyltransf_1 LANLAPFM_00161 585394.RHOM_06395 1.22e-166 484.0 COG1641@1|root,COG1641@2|Bacteria,1TPAV@1239|Firmicutes,247ZH@186801|Clostridia 186801|Clostridia P Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes larC - 4.99.1.12 ko:K09121 - - - - ko00000,ko01000 - - - DUF111 LANLAPFM_00162 585394.RHOM_06400 1.49e-147 419.0 COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia 186801|Clostridia S (AIR) carboxylase - - - ko:K06898 - - - - ko00000 - - - AIRC LANLAPFM_00163 1408323.JQKK01000005_gene154 4.41e-41 140.0 29PCB@1|root,30AAJ@2|Bacteria,1V4H2@1239|Firmicutes,24IF4@186801|Clostridia,27M51@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00164 622312.ROSEINA2194_02683 3.27e-292 805.0 COG2326@1|root,COG2326@2|Bacteria,1TQQR@1239|Firmicutes,249HE@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score pap - - - - - - - - - - - PPK2 LANLAPFM_00165 585394.RHOM_08170 1.64e-165 467.0 COG1082@1|root,COG1082@2|Bacteria,1U81K@1239|Firmicutes,2492P@186801|Clostridia 186801|Clostridia G Psort location Cytoplasmic, score - - - - - - - - - - - - AP_endonuc_2 LANLAPFM_00166 585394.RHOM_08175 1.65e-267 744.0 COG5434@1|root,COG5434@2|Bacteria,1TQQW@1239|Firmicutes,24A0R@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - Glyco_hydro_28,Pectate_lyase_3 LANLAPFM_00168 483218.BACPEC_01722 2.45e-275 774.0 COG0666@1|root,COG3507@1|root,COG0666@2|Bacteria,COG3507@2|Bacteria,1TP5K@1239|Firmicutes,247R2@186801|Clostridia,26AET@186813|unclassified Clostridiales 186801|Clostridia G Glycosyl hydrolases family 43 - - 3.2.1.37 ko:K01198 ko00520,ko01100,map00520,map01100 - R01433 RC00467 ko00000,ko00001,ko01000 - GH43 - Ank_2,Ank_4,Glyco_hydro_43 LANLAPFM_00169 515622.bpr_I1585 1.11e-208 598.0 COG3507@1|root,COG3507@2|Bacteria,1UDW2@1239|Firmicutes,24A81@186801|Clostridia,4BYGR@830|Butyrivibrio 186801|Clostridia G Glycosyl hydrolases family 43 - - - - - - - - - - - - Glyco_hydro_43 LANLAPFM_00170 1280668.ATVT01000001_gene794 1.39e-93 281.0 COG2755@1|root,COG2755@2|Bacteria,1V2SC@1239|Firmicutes,24H62@186801|Clostridia,4BWRN@830|Butyrivibrio 186801|Clostridia E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 LANLAPFM_00171 1298920.KI911353_gene1189 1.36e-146 419.0 COG0395@1|root,COG0395@2|Bacteria,1TSX2@1239|Firmicutes,24891@186801|Clostridia,222N7@1506553|Lachnoclostridium 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02026,ko:K17320 ko02010,map02010 M00207,M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 LANLAPFM_00172 1304866.K413DRAFT_2463 5.37e-108 320.0 COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,247UA@186801|Clostridia,36GXV@31979|Clostridiaceae 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K17319 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 LANLAPFM_00173 1298920.KI911353_gene1188 5.6e-20 88.6 COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,247UA@186801|Clostridia,222G1@1506553|Lachnoclostridium 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K17319 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 LANLAPFM_00174 1304866.K413DRAFT_2462 8.32e-230 650.0 COG1653@1|root,COG1653@2|Bacteria,1TW09@1239|Firmicutes,24BZW@186801|Clostridia,36G3C@31979|Clostridiaceae 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K17318 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - SBP_bac_1,SBP_bac_8 LANLAPFM_00175 622312.ROSEINA2194_01217 2.54e-75 232.0 COG2137@1|root,COG2137@2|Bacteria,1V72V@1239|Firmicutes,24J7X@186801|Clostridia 186801|Clostridia S Regulatory protein RecX recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX LANLAPFM_00176 622312.ROSEINA2194_01218 2.53e-217 605.0 COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia 186801|Clostridia L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA LANLAPFM_00178 585394.RHOM_08955 6.1e-53 169.0 COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia 186801|Clostridia O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin LANLAPFM_00179 585394.RHOM_08960 0.0 1030.0 COG4108@1|root,COG4108@2|Bacteria,1TPYT@1239|Firmicutes,247X3@186801|Clostridia 186801|Clostridia J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C LANLAPFM_00180 585394.RHOM_08965 6.56e-256 704.0 COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia 186801|Clostridia G Phosphotransfer between the C1 and C5 carbon atoms of pentose deoB - 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - - Metalloenzyme LANLAPFM_00181 622312.ROSEINA2194_01221 1.15e-95 288.0 28ZIG@1|root,2ZM9W@2|Bacteria,1V2JN@1239|Firmicutes,25BHX@186801|Clostridia 186801|Clostridia S SpoIIIAH-like protein - - - - - - - - - - - - SpoIIIAH LANLAPFM_00182 622312.ROSEINA2194_01222 9.54e-52 172.0 2E6BB@1|root,330Z5@2|Bacteria,1VF3M@1239|Firmicutes,24RAX@186801|Clostridia 186801|Clostridia S Stage III sporulation protein AG spoIIIAG - - ko:K06396 - - - - ko00000 - - - - LANLAPFM_00184 622312.ROSEINA2194_01224 3.92e-123 367.0 2C2CG@1|root,2Z7PW@2|Bacteria,1TQQ2@1239|Firmicutes,24AH2@186801|Clostridia 186801|Clostridia S stage III sporulation protein AE spoIIIAE - - ko:K06394 - - - - ko00000 - - - Spore_III_AE LANLAPFM_00185 585394.RHOM_09090 2.03e-44 148.0 2CPUI@1|root,32SJW@2|Bacteria,1VA9Y@1239|Firmicutes,24NK6@186801|Clostridia 186801|Clostridia S Stage III sporulation protein AD spoIIIAD - - ko:K06393 - - - - ko00000 - - - SpoIIIAC LANLAPFM_00186 585394.RHOM_09095 1.58e-33 115.0 2E555@1|root,32ZY3@2|Bacteria,1VEM4@1239|Firmicutes,24QNR@186801|Clostridia 186801|Clostridia S Stage III sporulation protein AC spoIIIAC - - ko:K06392 - - - - ko00000 - - - SpoIIIAC LANLAPFM_00187 397290.C810_02092 4.31e-09 60.5 29N29@1|root,30900@2|Bacteria,1U486@1239|Firmicutes,24GD0@186801|Clostridia,27PVV@186928|unclassified Lachnospiraceae 186801|Clostridia S Stage III sporulation protein AB (spore_III_AB) - - - - - - - - - - - - Spore_III_AB LANLAPFM_00188 585394.RHOM_09105 3.73e-125 367.0 COG3854@1|root,COG3854@2|Bacteria,1TQ23@1239|Firmicutes,248S2@186801|Clostridia 186801|Clostridia S stage III sporulation protein AA spoIIIAA - - ko:K06390 - - - - ko00000 - - - T2SSE LANLAPFM_00189 483218.BACPEC_01486 5.25e-184 518.0 28JHK@1|root,2Z9B4@2|Bacteria,1TS7Y@1239|Firmicutes,249S0@186801|Clostridia,26AQK@186813|unclassified Clostridiales 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_00190 742765.HMPREF9457_01596 0.0 890.0 COG1966@1|root,COG1966@2|Bacteria,1TQN8@1239|Firmicutes,248DZ@186801|Clostridia,27WC8@189330|Dorea 186801|Clostridia T 5TM C-terminal transporter carbon starvation CstA cstA - - - - - - - - - - - CstA,CstA_5TM LANLAPFM_00191 411459.RUMOBE_02708 1.41e-94 288.0 COG1609@1|root,COG1609@2|Bacteria,1UK1H@1239|Firmicutes,249XN@186801|Clostridia,3XZFY@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 9.98 - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 LANLAPFM_00192 140626.JHWB01000022_gene2045 8.62e-107 315.0 COG0406@1|root,COG0406@2|Bacteria,1U7UE@1239|Firmicutes,24F5B@186801|Clostridia 186801|Clostridia G Psort location Cytoplasmic, score - - - - - - - - - - - - His_Phos_1 LANLAPFM_00195 622312.ROSEINA2194_04314 7.61e-235 652.0 COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia 186801|Clostridia E Cleaves the N-terminal amino acid of tripeptides pepT - 3.4.11.4 ko:K01258 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M42 LANLAPFM_00196 1280688.AUJB01000009_gene1639 1.29e-15 88.6 2EAR0@1|root,334T8@2|Bacteria,1VAT6@1239|Firmicutes,24NCB@186801|Clostridia,3NGVW@46205|Pseudobutyrivibrio 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00197 585394.RHOM_16785 5.27e-278 766.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia 186801|Clostridia V Mate efflux family protein mepA_2 - - - - - - - - - - - MatE LANLAPFM_00198 585394.RHOM_13430 2.83e-143 406.0 2DB6M@1|root,2Z7HS@2|Bacteria,1U8V8@1239|Firmicutes,249IN@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF2871 LANLAPFM_00199 483218.BACPEC_02760 3.58e-80 240.0 COG1846@1|root,COG1846@2|Bacteria,1V3G1@1239|Firmicutes,24G8T@186801|Clostridia,26CGS@186813|unclassified Clostridiales 186801|Clostridia K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - HTH_27,MarR,MarR_2 LANLAPFM_00200 483218.BACPEC_02215 2.33e-149 420.0 COG1838@1|root,COG1838@2|Bacteria,1TSJ8@1239|Firmicutes,25CDD@186801|Clostridia,269T7@186813|unclassified Clostridiales 186801|Clostridia C Fumarase C-terminus ttdB - 4.2.1.2,4.2.1.32 ko:K01678,ko:K03780 ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00339,R01082 RC00443,RC01382 ko00000,ko00001,ko00002,ko01000 - - - Fumerase_C LANLAPFM_00201 483218.BACPEC_02216 6.18e-219 604.0 COG1951@1|root,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,248T7@186801|Clostridia,2685W@186813|unclassified Clostridiales 186801|Clostridia C Fumarate hydratase (Fumerase) - - 4.2.1.32 ko:K03779 ko00630,map00630 - R00339 RC01382 ko00000,ko00001,ko01000 - - - Fumerase LANLAPFM_00202 483218.BACPEC_02217 7.42e-278 764.0 COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,24D6M@186801|Clostridia,26A6P@186813|unclassified Clostridiales 186801|Clostridia P Sodium:sulfate symporter transmembrane region - - - - - - - - - - - - CitMHS,Na_sulph_symp LANLAPFM_00203 483218.BACPEC_02218 1.63e-137 393.0 COG0583@1|root,COG0583@2|Bacteria,1TQ6Y@1239|Firmicutes,25C6V@186801|Clostridia 186801|Clostridia K lysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate LANLAPFM_00204 622312.ROSEINA2194_04272 1.43e-308 843.0 COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia 186801|Clostridia V Mate efflux family protein - - - - - - - - - - - - MatE LANLAPFM_00205 622312.ROSEINA2194_04268 0.0 1154.0 COG0366@1|root,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.133,3.2.1.135,3.2.1.54 ko:K01208 ko00500,ko01100,map00500,map01100 - R02112,R03122,R11262 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Alpha-amylase_N,Malt_amylase_C LANLAPFM_00206 585394.RHOM_14630 3.92e-279 768.0 COG0569@1|root,COG0569@2|Bacteria,1TPNS@1239|Firmicutes,24830@186801|Clostridia 186801|Clostridia P domain protein trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N LANLAPFM_00207 585394.RHOM_14635 4.26e-262 728.0 COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,248K4@186801|Clostridia 186801|Clostridia P Cation transport protein trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH LANLAPFM_00208 622312.ROSEINA2194_02047 9.38e-194 538.0 COG1092@1|root,COG1092@2|Bacteria,1TPUD@1239|Firmicutes,2480X@186801|Clostridia 186801|Clostridia J Psort location Cytoplasmic, score rlmL_1 - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM LANLAPFM_00209 585394.RHOM_14710 7.89e-186 521.0 COG0598@1|root,COG0598@2|Bacteria,1TPI8@1239|Firmicutes,24956@186801|Clostridia 186801|Clostridia P Mg2 transporter protein corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA LANLAPFM_00210 585394.RHOM_14715 2.1e-82 248.0 COG1247@1|root,COG1247@2|Bacteria,1V6X5@1239|Firmicutes,24IB5@186801|Clostridia 186801|Clostridia M Acetyltransferase GNAT family yncA - 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 - R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 - - - Acetyltransf_4 LANLAPFM_00211 720554.Clocl_3524 2.85e-70 222.0 COG0637@1|root,COG0637@2|Bacteria,1V1DF@1239|Firmicutes,24DES@186801|Clostridia,3WS73@541000|Ruminococcaceae 186801|Clostridia S IA, variant 3 - - - - - - - - - - - - HAD_2 LANLAPFM_00212 411468.CLOSCI_03983 2.85e-92 276.0 COG0352@1|root,COG0352@2|Bacteria,1V3ZR@1239|Firmicutes,24DG3@186801|Clostridia,21ZN5@1506553|Lachnoclostridium 186801|Clostridia H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI LANLAPFM_00213 1235799.C818_03344 7.93e-104 311.0 COG2145@1|root,COG2145@2|Bacteria,1V1R6@1239|Firmicutes,248AC@186801|Clostridia,27IRB@186928|unclassified Lachnospiraceae 186801|Clostridia H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ) thiM - 2.7.1.50 ko:K00878 ko00730,ko01100,map00730,map01100 M00127 R04448 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HK LANLAPFM_00214 585394.RHOM_14750 7.73e-93 280.0 2AYHW@1|root,31QMC@2|Bacteria,1V6S7@1239|Firmicutes,24NBV@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - TraX LANLAPFM_00215 622312.ROSEINA2194_02031 1.38e-157 442.0 COG0284@1|root,COG0284@2|Bacteria,1TPPH@1239|Firmicutes,24DII@186801|Clostridia 186801|Clostridia F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase LANLAPFM_00216 585394.RHOM_06725 1.41e-194 574.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia 186801|Clostridia NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 LANLAPFM_00218 411489.CLOL250_00613 5.86e-42 144.0 COG0507@1|root,COG0507@2|Bacteria,1VAZW@1239|Firmicutes,24NP3@186801|Clostridia 186801|Clostridia L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - - LANLAPFM_00220 585394.RHOM_11955 2.45e-156 446.0 COG2333@1|root,COG2333@2|Bacteria,1UEY5@1239|Firmicutes,24E8K@186801|Clostridia 186801|Clostridia S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B LANLAPFM_00221 483218.BACPEC_02375 1.25e-204 575.0 COG1004@1|root,COG1004@2|Bacteria,1TQFN@1239|Firmicutes,25B1W@186801|Clostridia,2682F@186813|unclassified Clostridiales 186801|Clostridia M UDP binding domain ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N LANLAPFM_00222 585394.RHOM_11950 0.0 1138.0 COG0463@1|root,COG1216@1|root,COG0463@2|Bacteria,COG1216@2|Bacteria,1TQU0@1239|Firmicutes,248HP@186801|Clostridia 186801|Clostridia M Glycosyltransferase, group 2 family protein - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2 LANLAPFM_00223 585394.RHOM_11945 7.2e-33 114.0 2E96G@1|root,333F2@2|Bacteria,1VHVR@1239|Firmicutes,24SE5@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00224 585394.RHOM_11940 0.0 914.0 COG1215@1|root,COG1216@1|root,COG1215@2|Bacteria,COG1216@2|Bacteria,1TQU0@1239|Firmicutes,248HP@186801|Clostridia 186801|Clostridia M Glycosyltransferase, group 2 family protein - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2 LANLAPFM_00225 622312.ROSEINA2194_02504 1.54e-155 444.0 COG1216@1|root,COG1216@2|Bacteria,1TSTE@1239|Firmicutes,249WH@186801|Clostridia 186801|Clostridia M Glycosyltransferase, group 2 family protein - - - ko:K07011 - - - - ko00000 - - - Glycos_transf_2 LANLAPFM_00226 585394.RHOM_11930 1.51e-300 824.0 COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,248WV@186801|Clostridia 186801|Clostridia M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase - - 2.7.8.6 ko:K00996 - - - - ko00000,ko01000,ko01005 - - - Bac_transf,CoA_binding_3 LANLAPFM_00227 585394.RHOM_11925 1.27e-187 531.0 COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,248RH@186801|Clostridia 186801|Clostridia K Cell envelope-like function transcriptional attenuator common domain protein - - - - - - - - - - - - LytR_cpsA_psr LANLAPFM_00228 585394.RHOM_11920 7.28e-160 456.0 COG1216@1|root,COG1216@2|Bacteria,1TSXW@1239|Firmicutes,2499G@186801|Clostridia 186801|Clostridia S Glycosyltransferase, group 2 family protein - - - ko:K12992 ko02025,map02025 - - - ko00000,ko00001,ko01000,ko01003,ko01005 - GT2 - Glycos_transf_2 LANLAPFM_00229 622312.ROSEINA2194_01652 0.0 1267.0 COG1199@1|root,COG1199@2|Bacteria,1TQHQ@1239|Firmicutes,25C6H@186801|Clostridia 186801|Clostridia L helicase involved in DNA repair and perhaps also replication - - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - Helicase_C_2 LANLAPFM_00230 622312.ROSEINA2194_01654 5.58e-53 167.0 2DMSX@1|root,32TG6@2|Bacteria,1VCKS@1239|Firmicutes,24P39@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00231 622312.ROSEINA2194_01655 0.0 1060.0 COG1961@1|root,COG1961@2|Bacteria,1TPA6@1239|Firmicutes,247KF@186801|Clostridia 186801|Clostridia L Psort location Cytoplasmic, score - - - - - - - - - - - - DUF4368,Recombinase,Resolvase,Zn_ribbon_recom LANLAPFM_00232 1235800.C819_00786 8.48e-243 686.0 COG1961@1|root,COG1961@2|Bacteria,1TQ8Y@1239|Firmicutes,247WD@186801|Clostridia,27T7X@186928|unclassified Lachnospiraceae 186801|Clostridia L Recombinase zinc beta ribbon domain - - - - - - - - - - - - DUF4368,Recombinase,Resolvase,Zn_ribbon_recom LANLAPFM_00233 622312.ROSEINA2194_03305 0.0 895.0 COG1961@1|root,COG1961@2|Bacteria,1TSXI@1239|Firmicutes,248RE@186801|Clostridia 186801|Clostridia L Psort location Cytoplasmic, score - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom LANLAPFM_00235 397291.C804_05617 7.4e-94 276.0 COG1443@1|root,COG1443@2|Bacteria,1V41D@1239|Firmicutes,24KU4@186801|Clostridia,27M9G@186928|unclassified Lachnospiraceae 186801|Clostridia I NUDIX domain idi - - - - - - - - - - - NUDIX LANLAPFM_00236 515620.EUBELI_01734 4.4e-230 644.0 COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,25V84@186806|Eubacteriaceae 186801|Clostridia V MATE efflux family protein - - - - - - - - - - - - MatE LANLAPFM_00237 411474.COPEUT_00455 0.0 1250.0 COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia 186801|Clostridia P transporter of a GTP-driven Fe(2 ) uptake system feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoA,FeoB_C,FeoB_N,Gate LANLAPFM_00238 622312.ROSEINA2194_01846 2.25e-280 780.0 COG4822@1|root,COG4822@2|Bacteria,1TQ5V@1239|Firmicutes,24ABG@186801|Clostridia 186801|Clostridia H cobalt chelatase cbiK - 4.99.1.3 ko:K02190 ko00860,ko01100,map00860,map01100 - R05807 RC01012 ko00000,ko00001,ko01000 - - - CbiK LANLAPFM_00239 1256908.HMPREF0373_02031 1.14e-257 720.0 COG0614@1|root,COG0614@2|Bacteria,1TQ4U@1239|Firmicutes,249I2@186801|Clostridia,25UTP@186806|Eubacteriaceae 186801|Clostridia P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 LANLAPFM_00240 1256908.HMPREF0373_02030 2.89e-180 508.0 COG0609@1|root,COG0609@2|Bacteria,1TQXW@1239|Firmicutes,249TJ@186801|Clostridia,25VB9@186806|Eubacteriaceae 186801|Clostridia P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily btuC - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD LANLAPFM_00241 1256908.HMPREF0373_02029 3.83e-185 525.0 COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,25VKN@186806|Eubacteriaceae 186801|Clostridia HP K02013 iron complex transport system ATP-binding protein fepC - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran,zf-like LANLAPFM_00242 592026.GCWU0000282_002961 0.0 1339.0 COG1112@1|root,COG1112@2|Bacteria,1TP20@1239|Firmicutes,24BMH@186801|Clostridia 186801|Clostridia L COG1112 Superfamily I DNA and RNA - - - - - - - - - - - - AAA_11,AAA_12,DUF2726 LANLAPFM_00243 478749.BRYFOR_06207 1.32e-104 310.0 COG2186@1|root,COG2186@2|Bacteria,1V5UA@1239|Firmicutes,24BCM@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - ko:K05799 - - - - ko00000,ko03000 - - - FCD,GntR LANLAPFM_00244 478749.BRYFOR_06209 2.77e-255 708.0 COG2610@1|root,COG2610@2|Bacteria,1TQ14@1239|Firmicutes,248PQ@186801|Clostridia 186801|Clostridia EG Gluconate - - - ko:K03299,ko:K06155,ko:K06156,ko:K06157 - - - - ko00000,ko02000 2.A.8,2.A.8.1.2,2.A.8.1.4,2.A.8.1.8 - iHN637.CLJU_RS05690,iHN637.CLJU_RS13905 GntP_permease LANLAPFM_00245 457421.CBFG_01718 0.0 1022.0 COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia 186801|Clostridia EG Belongs to the IlvD Edd family - - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD LANLAPFM_00246 1121871.AUAT01000005_gene1736 5.02e-16 85.9 COG2971@1|root,COG2971@2|Bacteria,1V47Z@1239|Firmicutes,4IR14@91061|Bacilli 91061|Bacilli G BadF/BadG/BcrA/BcrD ATPase family - - - - - - - - - - - - BcrAD_BadFG LANLAPFM_00247 140626.JHWB01000009_gene1454 4.79e-117 341.0 COG0363@1|root,COG0363@2|Bacteria,1TP10@1239|Firmicutes,248HK@186801|Clostridia 186801|Clostridia G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion nagB - 3.5.99.6 ko:K02564 ko00520,ko01100,map00520,map01100 - R00765 RC00163 ko00000,ko00001,ko01000 - - - Glucosamine_iso LANLAPFM_00248 1280664.AUIX01000021_gene2964 7.38e-171 489.0 COG1820@1|root,COG1820@2|Bacteria,1TPFK@1239|Firmicutes,2481N@186801|Clostridia,4BX6M@830|Butyrivibrio 186801|Clostridia G Amidohydrolase family nagA - 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 - R02059 RC00166,RC00300 ko00000,ko00001,ko01000 - - - Amidohydro_1 LANLAPFM_00249 585394.RHOM_14935 0.0 975.0 COG0166@1|root,COG0166@2|Bacteria,1TP29@1239|Firmicutes,2487A@186801|Clostridia 186801|Clostridia G Belongs to the GPI family pgi - 2.2.1.2,5.3.1.9 ko:K01810,ko:K13810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00004,M00007,M00114 R01827,R02739,R02740,R03321 RC00376,RC00439,RC00563,RC00604 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI LANLAPFM_00250 585394.RHOM_14920 4.22e-227 628.0 COG0275@1|root,COG0275@2|Bacteria,1TP5R@1239|Firmicutes,248PH@186801|Clostridia 186801|Clostridia M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH2 - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 LANLAPFM_00251 411489.CLOL250_02329 2.27e-169 478.0 COG0214@1|root,COG0214@2|Bacteria,1TPSZ@1239|Firmicutes,248C1@186801|Clostridia,36DZ4@31979|Clostridiaceae 186801|Clostridia H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively pdxS - 4.3.3.6 ko:K06215 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SOR_SNZ LANLAPFM_00252 411489.CLOL250_02328 1.4e-76 234.0 COG0311@1|root,COG0311@2|Bacteria,1V3I6@1239|Firmicutes,24HRT@186801|Clostridia,36I0R@31979|Clostridiaceae 186801|Clostridia H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS pdxT - 4.3.3.6 ko:K08681 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS19495 SNO LANLAPFM_00253 742740.HMPREF9474_02025 9.15e-142 420.0 COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,22083@1506553|Lachnoclostridium 186801|Clostridia V MatE effD - - - - - - - - - - - MatE LANLAPFM_00254 483218.BACPEC_03086 7.68e-62 194.0 2BIDU@1|root,32CK4@2|Bacteria,1VDRI@1239|Firmicutes,24NJ9@186801|Clostridia,26BYT@186813|unclassified Clostridiales 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00255 622312.ROSEINA2194_00274 6.74e-181 509.0 COG3049@1|root,COG3049@2|Bacteria,1TPZS@1239|Firmicutes,24B0E@186801|Clostridia 186801|Clostridia M Linear amide C-N hydrolase, choloylglycine hydrolase family protein cbh - 3.5.1.24 ko:K01442 ko00120,ko00121,ko01100,map00120,map00121,map01100 - R02797,R03975,R03977,R04486,R04487,R05835 RC00090,RC00096 ko00000,ko00001,ko01000 - - - CBAH LANLAPFM_00256 411474.COPEUT_02079 2.24e-115 341.0 COG0583@1|root,COG0583@2|Bacteria,1TRVX@1239|Firmicutes,24B1W@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_1,LysR_substrate LANLAPFM_00257 585394.RHOM_02250 5.31e-119 345.0 COG2364@1|root,COG2364@2|Bacteria,1US08@1239|Firmicutes,24DPK@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - LANLAPFM_00258 1235793.C809_01339 2e-37 129.0 COG1970@1|root,COG1970@2|Bacteria,1VA14@1239|Firmicutes,24JAB@186801|Clostridia,27NWQ@186928|unclassified Lachnospiraceae 186801|Clostridia M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL - - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL LANLAPFM_00259 642492.Clole_0471 3.45e-245 701.0 COG2234@1|root,COG2234@2|Bacteria,1TRWH@1239|Firmicutes,24BM1@186801|Clostridia 186801|Clostridia S PA domain - - - - - - - - - - - - PA,Peptidase_M28 LANLAPFM_00260 1121115.AXVN01000103_gene864 1.18e-100 297.0 COG0454@1|root,COG0456@2|Bacteria,1V1I9@1239|Firmicutes,24GXQ@186801|Clostridia 186801|Clostridia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10 LANLAPFM_00261 622312.ROSEINA2194_00835 1.74e-30 110.0 COG2747@1|root,COG2747@2|Bacteria,1VFH9@1239|Firmicutes,24QZ8@186801|Clostridia 186801|Clostridia KNU Anti-sigma-28 factor, FlgM flgM - - ko:K02398 ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040 - - - ko00000,ko00001,ko02035 - - - FlgM LANLAPFM_00262 585394.RHOM_00615 1.12e-58 187.0 2APQ2@1|root,31ETS@2|Bacteria,1V6HK@1239|Firmicutes,24KPZ@186801|Clostridia 186801|Clostridia S FlgN protein - - - - - - - - - - - - FlgN LANLAPFM_00263 585394.RHOM_00620 4.62e-300 833.0 COG1256@1|root,COG1256@2|Bacteria,1TPXH@1239|Firmicutes,249PE@186801|Clostridia 186801|Clostridia N TIGRFAM Flagellar hook-associated protein, FlgK flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C LANLAPFM_00264 585394.RHOM_00625 7.68e-281 786.0 COG1256@1|root,COG1256@2|Bacteria,1TPXH@1239|Firmicutes,249PE@186801|Clostridia 186801|Clostridia N TIGRFAM Flagellar hook-associated protein, FlgK flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C LANLAPFM_00265 585394.RHOM_00630 3.65e-233 658.0 COG1344@1|root,COG1344@2|Bacteria,1TPDT@1239|Firmicutes,248FN@186801|Clostridia 186801|Clostridia N Belongs to the bacterial flagellin family flgL - - ko:K02397 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N LANLAPFM_00266 585394.RHOM_00635 2.94e-77 233.0 COG1699@1|root,COG1699@2|Bacteria,1VA6Y@1239|Firmicutes,24QXE@186801|Clostridia 186801|Clostridia S Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum fliW - - ko:K13626 - - - - ko00000,ko02035 - - - FliW LANLAPFM_00267 585394.RHOM_00640 1.92e-35 121.0 COG1551@1|root,COG1551@2|Bacteria,1VEEF@1239|Firmicutes,24QPD@186801|Clostridia 186801|Clostridia T Could accelerate the degradation of some genes transcripts potentially through selective RNA binding csrA - - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA LANLAPFM_00268 622312.ROSEINA2194_00379 7e-36 128.0 COG1334@1|root,COG1334@2|Bacteria,1VFRY@1239|Firmicutes,24QPX@186801|Clostridia 186801|Clostridia N PFAM Flagellar protein FlaG protein flaG - - ko:K06603 - - - - ko00000,ko02035 - - - FlaG LANLAPFM_00269 585394.RHOM_00650 0.0 1093.0 COG1345@1|root,COG1345@2|Bacteria,1TQ66@1239|Firmicutes,248Q9@186801|Clostridia 186801|Clostridia N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end fliD - - ko:K02407 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_IN,FliD_C,FliD_N LANLAPFM_00270 585394.RHOM_00655 2.4e-70 213.0 COG1516@1|root,COG1516@2|Bacteria,1VA8K@1239|Firmicutes,24MRW@186801|Clostridia 186801|Clostridia N flagellar protein flis fliS - - ko:K02422 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliS LANLAPFM_00271 585394.RHOM_00660 2.92e-73 223.0 2CW8V@1|root,32SZ6@2|Bacteria,1VAWT@1239|Firmicutes,24N6N@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - FlgN LANLAPFM_00272 622312.ROSEINA2194_00384 9.58e-162 457.0 COG1344@1|root,COG1344@2|Bacteria,1TP1K@1239|Firmicutes,247JQ@186801|Clostridia 186801|Clostridia N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella - - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N LANLAPFM_00273 622312.ROSEINA2194_00387 5.4e-221 616.0 COG4641@1|root,COG4641@2|Bacteria,1TR7G@1239|Firmicutes,249U5@186801|Clostridia 186801|Clostridia P DUF based on E. rectale Gene description (DUF3880) - - - ko:K06320 - - - - ko00000 - - - DUF3880,Glyco_trans_1_2 LANLAPFM_00274 622312.ROSEINA2194_00388 1.07e-212 595.0 COG4641@1|root,COG4641@2|Bacteria,1TS28@1239|Firmicutes,24E2J@186801|Clostridia 186801|Clostridia S DUF based on E. rectale Gene description (DUF3880) - - - ko:K06320 - - - - ko00000 - - - DUF3880,Glyco_trans_1_2 LANLAPFM_00275 622312.ROSEINA2194_00389 1.73e-232 640.0 COG1086@1|root,COG1086@2|Bacteria,1TPTC@1239|Firmicutes,247YC@186801|Clostridia 186801|Clostridia M Polysaccharide biosynthesis protein pseB - 4.2.1.115 ko:K15894 ko00520,map00520 - R09697 RC02609 ko00000,ko00001,ko01000 - - - Polysacc_synt_2 LANLAPFM_00276 585394.RHOM_00700 2.22e-280 766.0 COG0037@1|root,COG0037@2|Bacteria,1V1S0@1239|Firmicutes,24BSC@186801|Clostridia 186801|Clostridia D tRNA processing - - - - - - - - - - - - - LANLAPFM_00277 585394.RHOM_00705 4.9e-119 343.0 COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia 186801|Clostridia E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase LANLAPFM_00278 622312.ROSEINA2194_00393 4.89e-161 453.0 COG0107@1|root,COG0107@2|Bacteria,1VRBC@1239|Firmicutes,24Y72@186801|Clostridia 186801|Clostridia E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit - - - - - - - - - - - - His_biosynth LANLAPFM_00279 622312.ROSEINA2194_00394 7.61e-275 764.0 COG4641@1|root,COG4641@2|Bacteria,1UMWB@1239|Firmicutes,24CQX@186801|Clostridia 186801|Clostridia S Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_2 LANLAPFM_00280 622312.ROSEINA2194_00395 3.23e-57 181.0 2C12Y@1|root,32STC@2|Bacteria,1VCPE@1239|Firmicutes,24Q1P@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00281 622312.ROSEINA2194_00397 3.33e-309 860.0 COG1887@1|root,COG1887@2|Bacteria,1UY3V@1239|Firmicutes,24FED@186801|Clostridia 186801|Clostridia M Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC - - - - - - - - - - - - Glyphos_transf LANLAPFM_00282 1235793.C809_02425 8.91e-55 173.0 2C5R4@1|root,31VPY@2|Bacteria,1V8EP@1239|Firmicutes,24JPJ@186801|Clostridia,27MNA@186928|unclassified Lachnospiraceae 186801|Clostridia S Transposon-encoded protein TnpV - - - - - - - - - - - - TnpV LANLAPFM_00283 518637.EUBIFOR_01475 7.09e-19 84.3 COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,3VQ8R@526524|Erysipelotrichia 526524|Erysipelotrichia S Oxidoreductase, aldo keto reductase family protein - - - - - - - - - - - - Aldo_ket_red LANLAPFM_00284 1458427.BAWN01000009_gene613 1.82e-16 88.2 COG2199@1|root,COG3706@2|Bacteria,1NECV@1224|Proteobacteria,2VNH2@28216|Betaproteobacteria,4ACVV@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,MASE2 LANLAPFM_00285 622312.ROSEINA2194_04371 4.15e-172 484.0 COG1284@1|root,COG1284@2|Bacteria,1TYTP@1239|Firmicutes,25CBP@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF2179,YitT_membrane LANLAPFM_00286 397291.C804_04805 4.58e-209 591.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,27IAA@186928|unclassified Lachnospiraceae 186801|Clostridia V Polysaccharide biosynthesis C-terminal domain - - - - - - - - - - - - MatE LANLAPFM_00287 556261.HMPREF0240_03527 0.0 917.0 COG4637@1|root,COG4637@2|Bacteria,1UZCB@1239|Firmicutes,248WE@186801|Clostridia,36PCY@31979|Clostridiaceae 186801|Clostridia S AAA ATPase domain - - - - - - - - - - - - AAA_15,AAA_21 LANLAPFM_00288 397287.C807_02411 7.26e-84 253.0 COG4720@1|root,COG4720@2|Bacteria,1V5I7@1239|Firmicutes,25CJU@186801|Clostridia,27U5H@186928|unclassified Lachnospiraceae 186801|Clostridia S Pfam:DUF3816 - - - - - - - - - - - - ECF_trnsprt LANLAPFM_00289 585394.RHOM_05960 6.19e-223 629.0 COG0144@1|root,COG3270@1|root,COG0144@2|Bacteria,COG3270@2|Bacteria,1TPGQ@1239|Firmicutes,247N0@186801|Clostridia 186801|Clostridia J NOL1 NOP2 sun family - - - - - - - - - - - - Methyltr_RsmB-F,Methyltr_RsmF_N,Methyltranf_PUA,RsmF_methylt_CI LANLAPFM_00290 1235793.C809_02152 1.52e-206 580.0 COG4804@1|root,COG4804@2|Bacteria,1TP7Q@1239|Firmicutes,24A19@186801|Clostridia,27TF6@186928|unclassified Lachnospiraceae 186801|Clostridia S Protein of unknown function (DUF1016) - - - - - - - - - - - - DUF1016 LANLAPFM_00291 1226325.HMPREF1548_02362 8.29e-232 644.0 COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,248AY@186801|Clostridia,36DKQ@31979|Clostridiaceae 186801|Clostridia E PFAM Aminotransferase class I and II - - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 LANLAPFM_00292 658086.HMPREF0994_00210 0.0 897.0 COG1757@1|root,COG1757@2|Bacteria,1TQ3B@1239|Firmicutes,248WN@186801|Clostridia,27TF9@186928|unclassified Lachnospiraceae 186801|Clostridia C Na+/H+ antiporter family nhaC - - ko:K03315 - - - - ko00000,ko02000 2.A.35 - - Na_H_antiporter LANLAPFM_00293 658086.HMPREF0994_00211 4.79e-63 195.0 COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,24J8Y@186801|Clostridia,27N9W@186928|unclassified Lachnospiraceae 186801|Clostridia J Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP LANLAPFM_00294 585394.RHOM_09030 4.85e-225 641.0 COG0079@1|root,COG2082@1|root,COG0079@2|Bacteria,COG2082@2|Bacteria,1TP5D@1239|Firmicutes,248Q0@186801|Clostridia 186801|Clostridia E PFAM Aminotransferase class I and II cobD_2 - 4.1.1.81 ko:K04720 ko00860,map00860 - R06530 RC00517 ko00000,ko00001,ko01000 - - - Aminotran_1_2 LANLAPFM_00295 622312.ROSEINA2194_01855 3.89e-167 480.0 COG1903@1|root,COG1903@2|Bacteria,1TQ3M@1239|Firmicutes,248AK@186801|Clostridia 186801|Clostridia H Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A cbiD - 2.1.1.195 ko:K02188 ko00860,ko01100,map00860,map01100 - R07773 RC00003,RC02051 ko00000,ko00001,ko01000 - - - CbiD LANLAPFM_00296 622312.ROSEINA2194_01854 3.25e-135 388.0 COG2875@1|root,COG2875@2|Bacteria,1TP6J@1239|Firmicutes,248IZ@186801|Clostridia 186801|Clostridia H precorrin-4 C(11)-methyltransferase cobM - 2.1.1.133,2.1.1.271 ko:K05936 ko00860,ko01100,map00860,map01100 - R05181,R05810 RC00003,RC01294,RC02049 ko00000,ko00001,ko01000 - - - TP_methylase LANLAPFM_00297 1469948.JPNB01000001_gene2323 1.29e-90 287.0 COG2073@1|root,COG2073@2|Bacteria,1TPYM@1239|Firmicutes,247JW@186801|Clostridia,36DM5@31979|Clostridiaceae 186801|Clostridia H Cobalamin biosynthesis protein cbiG cbiG - 3.7.1.12 ko:K02189 ko00860,ko01100,map00860,map01100 - R07772 RC01545,RC02097 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS15705 CbiG_C,CbiG_N,CbiG_mid LANLAPFM_00298 1120746.CCNL01000008_gene554 1.99e-128 370.0 COG1010@1|root,COG1010@2|Bacteria 2|Bacteria H Tetrapyrrole (Corrin/Porphyrin) Methylases cobJ - 2.1.1.131,2.1.1.133,2.1.1.271,3.7.1.12,6.3.5.10 ko:K02232,ko:K05934,ko:K05936,ko:K13541 ko00860,ko01100,map00860,map01100 M00122 R05180,R05181,R05225,R05809,R05810,R07772 RC00003,RC00010,RC01293,RC01294,RC01302,RC01545,RC02049,RC02097,RC03471 ko00000,ko00001,ko00002,ko01000 - - - CbiC,TP_methylase LANLAPFM_00299 1120746.CCNL01000008_gene555 1.31e-237 682.0 COG2099@1|root,COG2241@1|root,COG2242@1|root,COG2099@2|Bacteria,COG2241@2|Bacteria,COG2242@2|Bacteria 2|Bacteria H protein methyltransferase activity cobK - 1.3.1.106,1.3.1.54,1.3.1.76,2.1.1.131,2.1.1.132,2.1.1.196,2.1.1.289,3.7.1.12,4.99.1.4 ko:K00595,ko:K02191,ko:K02304,ko:K03399,ko:K05895,ko:K05934,ko:K13541 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03947,R05149,R05150,R05180,R05809,R05812,R05813,R07772,R07774,R07775 RC00003,RC01012,RC01034,RC01279,RC01280,RC01293,RC01545,RC02052,RC02053,RC02054,RC02097,RC03471 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS15725 CbiJ,Methyltransf_31,TP_methylase LANLAPFM_00300 397290.C810_02927 1.42e-180 524.0 COG1797@1|root,COG2158@1|root,COG1797@2|Bacteria,COG2158@2|Bacteria,1TNY2@1239|Firmicutes,247PU@186801|Clostridia,27IYT@186928|unclassified Lachnospiraceae 186801|Clostridia H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,CbiA,GATase_3 LANLAPFM_00301 1120746.CCNL01000008_gene565 1.39e-96 289.0 COG2243@1|root,COG2243@2|Bacteria 2|Bacteria H precorrin-2 c20-methyltransferase cobI - 2.1.1.130,2.1.1.151,4.99.1.3 ko:K02190,ko:K03394 ko00860,ko01100,map00860,map01100 - R03948,R05807,R05808 RC00003,RC01012,RC01035,RC01662 ko00000,ko00001,ko01000 - - - TP_methylase LANLAPFM_00302 585394.RHOM_08970 4.02e-39 131.0 COG2158@1|root,COG2158@2|Bacteria 2|Bacteria S Cysteine-rich small domain cbiA - - ko:K07162 - - - - ko00000 - - - zf-like LANLAPFM_00304 622312.ROSEINA2194_00478 1.79e-62 204.0 COG3773@1|root,COG3773@2|Bacteria,1VHG1@1239|Firmicutes,24SYE@186801|Clostridia 186801|Clostridia M COG3773 Cell wall hydrolyses involved in spore germination - - 3.5.1.28 ko:K01449 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - Hydrolase_2 LANLAPFM_00305 1163671.JAGI01000002_gene2184 1.33e-54 186.0 COG0037@1|root,COG0607@1|root,COG0037@2|Bacteria,COG0607@2|Bacteria,1TQ0Y@1239|Firmicutes,247RP@186801|Clostridia,36DIN@31979|Clostridiaceae 186801|Clostridia H Belongs to the TtcA family ttcA - - - - - - - - - - - ATP_bind_3,Rhodanese LANLAPFM_00306 622312.ROSEINA2194_03851 2.95e-42 141.0 2EH8T@1|root,33B0N@2|Bacteria,1VKIJ@1239|Firmicutes,24V3Q@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00307 585394.RHOM_08000 2.11e-59 186.0 COG4753@1|root,COG4753@2|Bacteria,1VAG0@1239|Firmicutes,24P6B@186801|Clostridia 186801|Clostridia T cheY-homologous receiver domain - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_18,Response_reg LANLAPFM_00308 585394.RHOM_08005 1.46e-107 321.0 COG1406@1|root,COG1406@2|Bacteria,1V46M@1239|Firmicutes,24B3C@186801|Clostridia 186801|Clostridia N Chemotaxis phosphatase CheX - - - - - - - - - - - - CheX LANLAPFM_00309 622312.ROSEINA2194_03854 3.56e-310 851.0 COG0498@1|root,COG0498@2|Bacteria,1TPR0@1239|Firmicutes,248YY@186801|Clostridia 186801|Clostridia E Threonine synthase thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS16355 PALP,Thr_synth_N LANLAPFM_00310 585394.RHOM_08020 3.18e-127 369.0 28NT4@1|root,2ZBRW@2|Bacteria,1UXVI@1239|Firmicutes,24ABY@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00311 483218.BACPEC_02992 1.78e-102 322.0 COG0840@1|root,COG0840@2|Bacteria,1TSW1@1239|Firmicutes,24B19@186801|Clostridia 186801|Clostridia NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal LANLAPFM_00312 1235802.C823_03008 5.92e-263 743.0 COG0840@1|root,COG1145@1|root,COG4624@1|root,COG0840@2|Bacteria,COG1145@2|Bacteria,COG4624@2|Bacteria,1TSVR@1239|Firmicutes,248TC@186801|Clostridia,25VKU@186806|Eubacteriaceae 186801|Clostridia CNT Iron only hydrogenase large subunit, C-terminal domain - - - - - - - - - - - - FeS,Fe_hyd_lg_C,Fer4,Fer4_10,Fer4_7,MCPsignal LANLAPFM_00313 585394.RHOM_08335 1.03e-156 443.0 COG1036@1|root,COG2878@1|root,COG1036@2|Bacteria,COG2878@2|Bacteria,1TQGD@1239|Firmicutes,24904@186801|Clostridia 186801|Clostridia C electron transport complex, RnfABCDGE type, B subunit rnfB - - ko:K03616 - - - - ko00000 - - - FeS,Fer4,Fer4_13,Fer4_4,Fer4_9 LANLAPFM_00314 585394.RHOM_08340 4.83e-123 352.0 COG4657@1|root,COG4657@2|Bacteria,1TS06@1239|Firmicutes,247UE@186801|Clostridia 186801|Clostridia C Part of a membrane complex involved in electron transport rnfA - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr LANLAPFM_00315 585394.RHOM_08345 9.91e-139 395.0 COG4660@1|root,COG4660@2|Bacteria,1TSE7@1239|Firmicutes,24972@186801|Clostridia 186801|Clostridia C Part of a membrane complex involved in electron transport rnfE - - ko:K03613 - - - - ko00000 - - iHN637.CLJU_RS05585 Rnf-Nqr LANLAPFM_00316 585394.RHOM_08350 3.91e-106 310.0 COG4659@1|root,COG4659@2|Bacteria,1V7R1@1239|Firmicutes,24JVM@186801|Clostridia 186801|Clostridia C Part of a membrane complex involved in electron transport rnfG - - ko:K03612 - - - - ko00000 - - - FMN_bind LANLAPFM_00317 585394.RHOM_08355 1.52e-185 520.0 COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia 186801|Clostridia C Part of a membrane complex involved in electron transport rnfD - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE LANLAPFM_00318 585394.RHOM_08360 1.28e-278 766.0 COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia 186801|Clostridia C Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily rnfC - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4,Fer4_10,Fer4_7,Fer4_9,RnfC_N,SLBB LANLAPFM_00319 411463.EUBVEN_02693 1.23e-136 389.0 COG0356@1|root,COG0356@2|Bacteria,1TQIT@1239|Firmicutes,24A6Q@186801|Clostridia,25VMP@186806|Eubacteriaceae 186801|Clostridia C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A LANLAPFM_00320 585394.RHOM_14685 8.34e-38 127.0 COG0636@1|root,COG0636@2|Bacteria,1V8SD@1239|Firmicutes,24QMQ@186801|Clostridia 186801|Clostridia C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iHN637.CLJU_RS01165 ATP-synt_C LANLAPFM_00321 411463.EUBVEN_02695 8.25e-61 192.0 COG0711@1|root,COG0711@2|Bacteria,1VB85@1239|Firmicutes,24RWR@186801|Clostridia,25X82@186806|Eubacteriaceae 186801|Clostridia C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B LANLAPFM_00322 622312.ROSEINA2194_02212 1.64e-62 197.0 COG0712@1|root,COG0712@2|Bacteria,1UI0C@1239|Firmicutes,24G5C@186801|Clostridia 186801|Clostridia C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP LANLAPFM_00323 622312.ROSEINA2194_02211 0.0 875.0 COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N,OSCP LANLAPFM_00324 585394.RHOM_14665 6.19e-175 492.0 COG0224@1|root,COG0224@2|Bacteria,1TPBX@1239|Firmicutes,2486Q@186801|Clostridia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt LANLAPFM_00325 585394.RHOM_14660 0.0 871.0 COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,2489W@186801|Clostridia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N LANLAPFM_00326 585394.RHOM_14655 1.05e-77 233.0 COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,24ND7@186801|Clostridia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N LANLAPFM_00327 658086.HMPREF0994_01674 1.76e-68 222.0 COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1V41T@1239|Firmicutes,25B4Q@186801|Clostridia,27TZT@186928|unclassified Lachnospiraceae 186801|Clostridia K Cupin domain - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18,HTH_AraC LANLAPFM_00328 397291.C804_03759 0.0 1059.0 COG1472@1|root,COG1472@2|Bacteria,1TPH5@1239|Firmicutes,247QP@186801|Clostridia,27IMH@186928|unclassified Lachnospiraceae 186801|Clostridia G Fibronectin type III-like domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C LANLAPFM_00329 622312.ROSEINA2194_00571 0.0 1215.0 COG1472@1|root,COG1472@2|Bacteria,1TPH5@1239|Firmicutes,247QP@186801|Clostridia 186801|Clostridia G Glycosyl hydrolase family 3 N-terminal domain protein - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C LANLAPFM_00330 1256908.HMPREF0373_00101 0.0 1419.0 COG0058@1|root,COG0058@2|Bacteria,1TQAJ@1239|Firmicutes,248E1@186801|Clostridia,25VB4@186806|Eubacteriaceae 186801|Clostridia G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase LANLAPFM_00331 622312.ROSEINA2194_02271 0.0 1931.0 COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,247XX@186801|Clostridia 186801|Clostridia J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 LANLAPFM_00332 585394.RHOM_04250 1.37e-174 493.0 COG0618@1|root,COG0618@2|Bacteria,1UKBY@1239|Firmicutes,24EAR@186801|Clostridia 186801|Clostridia S DHH family - - - - - - - - - - - - DHH,DHHA1 LANLAPFM_00333 622312.ROSEINA2194_02268 2.33e-104 306.0 COG0546@1|root,COG0546@2|Bacteria,1V4W6@1239|Firmicutes,24DB6@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 LANLAPFM_00334 622312.ROSEINA2194_02267 1.25e-281 779.0 COG2317@1|root,COG2317@2|Bacteria,1TPS6@1239|Firmicutes,249NK@186801|Clostridia 186801|Clostridia E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues - - 3.4.17.19 ko:K01299 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M32 LANLAPFM_00335 585394.RHOM_03855 1.56e-256 703.0 COG0115@1|root,COG0115@2|Bacteria,1TQQI@1239|Firmicutes,2480D@186801|Clostridia 186801|Clostridia E Branched-chain amino acid aminotransferase ilvE - 2.6.1.42,4.1.3.38 ko:K00826,ko:K02619 ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R05553,R10991 RC00006,RC00036,RC01843,RC02148 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 LANLAPFM_00336 585394.RHOM_03850 1.62e-47 160.0 2E0ER@1|root,32W16@2|Bacteria,1VDMK@1239|Firmicutes,24T4F@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - ECF_trnsprt LANLAPFM_00337 585394.RHOM_14785 2.59e-99 290.0 COG1853@1|root,COG1853@2|Bacteria,1V41U@1239|Firmicutes,24HTA@186801|Clostridia 186801|Clostridia S Conserved protein domain typically associated with flavoprotein oxygenases DIM6 NTAB family - - - - - - - - - - - - Flavin_Reduct LANLAPFM_00338 478749.BRYFOR_07844 5.53e-76 243.0 COG5464@1|root,COG5464@2|Bacteria,1V3CA@1239|Firmicutes,24H4R@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - Transposase_31 LANLAPFM_00339 585394.RHOM_11755 0.0 887.0 COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,2484D@186801|Clostridia 186801|Clostridia J Asparaginyl-tRNA synthetase asnS - 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon LANLAPFM_00340 585394.RHOM_11760 2.36e-148 436.0 COG0544@1|root,COG0544@2|Bacteria,1V3TB@1239|Firmicutes,24I3U@186801|Clostridia 186801|Clostridia O Bacterial trigger factor protein (TF) C-terminus - - - - - - - - - - - - FKBP_C,Trigger_C LANLAPFM_00341 585394.RHOM_05010 2.38e-45 148.0 2EK04@1|root,33DQP@2|Bacteria,1VM4D@1239|Firmicutes,24WYN@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00342 585394.RHOM_05425 1.61e-139 398.0 28XBK@1|root,2ZJ9G@2|Bacteria,1V203@1239|Firmicutes,24E0K@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00343 585394.RHOM_05420 6.34e-313 852.0 COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,247X7@186801|Clostridia 186801|Clostridia E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC LANLAPFM_00344 585394.RHOM_05415 2.56e-53 169.0 COG1687@1|root,COG1687@2|Bacteria,1V9YS@1239|Firmicutes,24MSG@186801|Clostridia 186801|Clostridia E branched-chain amino acid azlD - - - - - - - - - - - AzlD LANLAPFM_00345 585394.RHOM_05410 3.33e-136 390.0 COG1296@1|root,COG1296@2|Bacteria,1TP8P@1239|Firmicutes,248NN@186801|Clostridia 186801|Clostridia E branched-chain amino acid permease (azaleucine resistance) - - - - - - - - - - - - AzlC LANLAPFM_00346 585394.RHOM_05405 5.76e-64 210.0 COG0741@1|root,COG0741@2|Bacteria,1V6DD@1239|Firmicutes,24JDA@186801|Clostridia 186801|Clostridia M transglycosylase yjbJ - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT LANLAPFM_00347 585394.RHOM_05400 7.13e-83 247.0 COG1846@1|root,COG1846@2|Bacteria,1V1U2@1239|Firmicutes,24FR9@186801|Clostridia 186801|Clostridia K MarR family - - - - - - - - - - - - MarR LANLAPFM_00348 622312.ROSEINA2194_02996 7.26e-167 472.0 COG0539@1|root,COG0539@2|Bacteria,1UYC5@1239|Firmicutes,24AJ1@186801|Clostridia 186801|Clostridia J S1 RNA binding domain protein rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 LANLAPFM_00349 585394.RHOM_11170 5.83e-206 608.0 COG0642@1|root,COG2205@2|Bacteria,1TP73@1239|Firmicutes,248Y6@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA LANLAPFM_00350 585394.RHOM_11175 9.86e-148 418.0 COG0745@1|root,COG0745@2|Bacteria,1TP9M@1239|Firmicutes,247TK@186801|Clostridia 186801|Clostridia KT response regulator receiver vanR3 - - - - - - - - - - - Response_reg,Trans_reg_C LANLAPFM_00351 1235793.C809_01831 7.87e-34 119.0 COG4818@1|root,COG4818@2|Bacteria,1UN6A@1239|Firmicutes,25GXJ@186801|Clostridia,27Q73@186928|unclassified Lachnospiraceae 186801|Clostridia S TM2 domain - - - - - - - - - - - - - LANLAPFM_00352 1449050.JNLE01000003_gene2095 3.88e-21 96.3 COG0304@1|root,COG2273@1|root,COG2340@1|root,COG3291@1|root,COG0304@2|Bacteria,COG2273@2|Bacteria,COG2340@2|Bacteria,COG3291@2|Bacteria,1TR5U@1239|Firmicutes,248GW@186801|Clostridia,36HJG@31979|Clostridiaceae 186801|Clostridia G family 16 - - - - - - - - - - - - CBM_4_9,DUF1533,Glyco_hydro_16,SLH LANLAPFM_00353 483218.BACPEC_00641 8.08e-40 140.0 COG0789@1|root,COG0789@2|Bacteria,1TS6Z@1239|Firmicutes,24AD8@186801|Clostridia,26CP4@186813|unclassified Clostridiales 186801|Clostridia K TipAS antibiotic-recognition domain mta - - - - - - - - - - - MerR_1,TipAS LANLAPFM_00355 1408312.JNJS01000004_gene2495 7.95e-149 425.0 COG1533@1|root,COG1533@2|Bacteria,1TSS2@1239|Firmicutes,248SB@186801|Clostridia,3NI14@46205|Pseudobutyrivibrio 186801|Clostridia L Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM LANLAPFM_00356 622312.ROSEINA2194_00812 4.47e-35 120.0 COG0236@1|root,COG0236@2|Bacteria,1VEE3@1239|Firmicutes,24QME@186801|Clostridia 186801|Clostridia IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding LANLAPFM_00357 622312.ROSEINA2194_00811 4.02e-181 508.0 COG2070@1|root,COG2070@2|Bacteria,1TPC3@1239|Firmicutes,24831@186801|Clostridia 186801|Clostridia S reductase II fabK - 1.3.1.9 ko:K02371 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - iHN637.CLJU_RS20775 NMO LANLAPFM_00358 622312.ROSEINA2194_00810 1.24e-151 434.0 COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,247UF@186801|Clostridia 186801|Clostridia I malonyl coa-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 LANLAPFM_00359 476272.RUMHYD_01858 1.07e-115 338.0 COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,3XYM7@572511|Blautia 186801|Clostridia IQ Psort location Cytoplasmic, score fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 LANLAPFM_00360 585394.RHOM_14065 1.5e-242 672.0 COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt LANLAPFM_00361 622312.ROSEINA2194_00807 1.53e-80 241.0 COG0764@1|root,COG0764@2|Bacteria,1V6EX@1239|Firmicutes,24JAW@186801|Clostridia 186801|Clostridia I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA LANLAPFM_00362 585394.RHOM_14055 0.0 942.0 COG0777@1|root,COG0825@1|root,COG0777@2|Bacteria,COG0825@2|Bacteria,1TP4U@1239|Firmicutes,248QK@186801|Clostridia 186801|Clostridia I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS20740 ACCA,Carboxyl_trans LANLAPFM_00363 622312.ROSEINA2194_00805 1.22e-164 468.0 COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C LANLAPFM_00365 585394.RHOM_14045 1.04e-78 236.0 COG1846@1|root,COG1846@2|Bacteria,1V6GY@1239|Firmicutes,24HTB@186801|Clostridia 186801|Clostridia K Transcriptional regulator, MarR family - - - - - - - - - - - - HTH_27,MarR,MarR_2 LANLAPFM_00366 622312.ROSEINA2194_02852 1.35e-176 498.0 COG0039@1|root,COG0039@2|Bacteria,1TPSY@1239|Firmicutes,248DH@186801|Clostridia 186801|Clostridia C Belongs to the LDH MDH superfamily. LDH family ldh - 1.1.1.27 ko:K00016 ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922 - R00703,R01000,R03104 RC00031,RC00044 ko00000,ko00001,ko01000,ko04147 - - - Ldh_1_C,Ldh_1_N LANLAPFM_00367 622312.ROSEINA2194_04459 1.72e-223 618.0 COG0524@1|root,COG0524@2|Bacteria,1TQ9Q@1239|Firmicutes,25B0T@186801|Clostridia 186801|Clostridia G Psort location Cytoplasmic, score - - 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PfkB LANLAPFM_00368 585394.RHOM_04000 4.62e-131 385.0 COG2355@1|root,COG2355@2|Bacteria,1UA7M@1239|Firmicutes,24AE6@186801|Clostridia 186801|Clostridia E PFAM Peptidase M19, renal dipeptidase - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 LANLAPFM_00369 500632.CLONEX_03577 1.24e-31 133.0 COG0772@1|root,COG0772@2|Bacteria,1TRIP@1239|Firmicutes,25DEX@186801|Clostridia 186801|Clostridia D Belongs to the SEDS family - - - - - - - - - - - - FTSW_RODA_SPOVE LANLAPFM_00370 1235798.C817_04466 7.15e-45 148.0 COG1695@1|root,COG1695@2|Bacteria,1VAKA@1239|Firmicutes,24MVF@186801|Clostridia,27VT5@189330|Dorea 186801|Clostridia K Transcriptional regulator, PadR family - - - ko:K10947 - - - - ko00000,ko03000 - - - PadR LANLAPFM_00371 592026.GCWU0000282_001791 1.49e-57 186.0 COG0685@1|root,COG0685@2|Bacteria,1TQFE@1239|Firmicutes,247ZK@186801|Clostridia 186801|Clostridia E 5,10-methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR LANLAPFM_00372 411489.CLOL250_02471 2.53e-34 126.0 COG0583@1|root,COG0583@2|Bacteria,1TP3E@1239|Firmicutes,248HI@186801|Clostridia,36ES0@31979|Clostridiaceae 186801|Clostridia K transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate LANLAPFM_00373 411463.EUBVEN_02650 4.13e-47 160.0 COG0583@1|root,COG0583@2|Bacteria,1TP3E@1239|Firmicutes,248HI@186801|Clostridia,25VUS@186806|Eubacteriaceae 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_1,LysR_substrate LANLAPFM_00374 1280679.ATVX01000004_gene452 6.3e-07 51.2 29155@1|root,2ZNSF@2|Bacteria,1W51U@1239|Firmicutes,257BM@186801|Clostridia,4C0H7@830|Butyrivibrio 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00375 585394.RHOM_03995 0.0 1372.0 COG0058@1|root,COG0058@2|Bacteria,1TQAJ@1239|Firmicutes,248E1@186801|Clostridia 186801|Clostridia G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties malP_1 - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase LANLAPFM_00376 622312.ROSEINA2194_02243 2.02e-168 475.0 COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1TSRS@1239|Firmicutes,24BXX@186801|Clostridia 186801|Clostridia K transcriptional regulator (AraC family) - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18,HTH_AraC LANLAPFM_00377 585394.RHOM_03350 3.68e-215 617.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1TS8B@1239|Firmicutes,24EZ4@186801|Clostridia 186801|Clostridia T GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_9 LANLAPFM_00378 585394.RHOM_11515 2.73e-56 181.0 COG0671@1|root,COG0671@2|Bacteria,1VB2R@1239|Firmicutes,24MQ9@186801|Clostridia 186801|Clostridia I Psort location CytoplasmicMembrane, score - - - - - - - - - - - - PAP2 LANLAPFM_00379 585394.RHOM_11510 7.6e-66 204.0 COG0597@1|root,COG0597@2|Bacteria,1VFDG@1239|Firmicutes,24PUH@186801|Clostridia 186801|Clostridia MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins - - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 LANLAPFM_00380 1235790.C805_02487 2.01e-70 220.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1URF2@1239|Firmicutes,24BBP@186801|Clostridia,25ZEW@186806|Eubacteriaceae 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,HTH_AraC,Response_reg LANLAPFM_00381 585394.RHOM_11710 1.83e-161 473.0 COG0845@1|root,COG0845@2|Bacteria,1V046@1239|Firmicutes,24ANJ@186801|Clostridia 186801|Clostridia M Efflux transporter, RND family, MFP subunit - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 LANLAPFM_00382 585394.RHOM_11705 1.68e-136 389.0 COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran LANLAPFM_00383 585394.RHOM_11700 9.28e-215 615.0 COG0845@1|root,COG0845@2|Bacteria,1UZ3U@1239|Firmicutes,24BV7@186801|Clostridia 186801|Clostridia M domain, Protein - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 LANLAPFM_00384 585394.RHOM_11695 6.42e-221 618.0 COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia 186801|Clostridia V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD LANLAPFM_00385 585394.RHOM_11690 9.49e-175 500.0 COG4641@1|root,COG4641@2|Bacteria,1UYE0@1239|Firmicutes,24D1Q@186801|Clostridia 186801|Clostridia M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_2 LANLAPFM_00386 622312.ROSEINA2194_04229 6.92e-298 814.0 COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia 186801|Clostridia J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b LANLAPFM_00387 585394.RHOM_11680 1.52e-120 344.0 COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,247XN@186801|Clostridia 186801|Clostridia O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase LANLAPFM_00388 585394.RHOM_11675 7.58e-121 355.0 29TA1@1|root,30EH1@2|Bacteria,1V43N@1239|Firmicutes,24IGU@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00390 585394.RHOM_11420 1.17e-176 507.0 COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia 186801|Clostridia G hydrolase, family 3 - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 LANLAPFM_00391 622312.ROSEINA2194_02225 7.06e-81 250.0 COG4862@1|root,COG4862@2|Bacteria 2|Bacteria NOT establishment of competence for transformation mecA GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K16511 - - - - ko00000 - - - MecA LANLAPFM_00393 585394.RHOM_12015 4.92e-143 411.0 COG2207@1|root,COG2207@2|Bacteria,1V1FV@1239|Firmicutes,24887@186801|Clostridia 186801|Clostridia K transcriptional regulator (AraC family) - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC LANLAPFM_00394 585394.RHOM_12025 3.07e-114 342.0 COG3594@1|root,COG3594@2|Bacteria,1VJ6T@1239|Firmicutes,24UK1@186801|Clostridia 186801|Clostridia G Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 LANLAPFM_00395 483218.BACPEC_02363 5.11e-292 815.0 COG0367@1|root,COG0367@2|Bacteria,1TRPB@1239|Firmicutes,247YA@186801|Clostridia,268P3@186813|unclassified Clostridiales 186801|Clostridia E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 LANLAPFM_00396 585394.RHOM_12030 5.76e-120 348.0 COG1922@1|root,COG1922@2|Bacteria,1UIHR@1239|Firmicutes,25BDH@186801|Clostridia 186801|Clostridia M Belongs to the glycosyltransferase 26 family - - 2.4.1.187 ko:K05946 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01003 - GT26 - CoA_binding_3,Glyco_tran_WecB LANLAPFM_00397 585394.RHOM_12035 3.36e-91 278.0 2DMX9@1|root,32U7V@2|Bacteria,1W0SU@1239|Firmicutes,24QVG@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00398 585394.RHOM_12040 6.04e-253 713.0 COG1132@1|root,COG1132@2|Bacteria,1TQAN@1239|Firmicutes,24BEK@186801|Clostridia 186801|Clostridia V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran LANLAPFM_00399 585394.RHOM_12075 3.62e-108 322.0 arCOG09486@1|root,2ZC3Y@2|Bacteria,1VABR@1239|Firmicutes,24F51@186801|Clostridia 186801|Clostridia S Glycosyl transferase family 11 - - - - - - - - - - - - Glyco_transf_11 LANLAPFM_00400 1123307.KB904364_gene1166 4.44e-76 255.0 COG1807@1|root,COG1807@2|Bacteria,1V11Z@1239|Firmicutes,4ISNZ@91061|Bacilli 91061|Bacilli M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 LANLAPFM_00402 632245.CLP_3145 1.64e-96 292.0 COG0382@1|root,COG0382@2|Bacteria,1TRTB@1239|Firmicutes,24AQ0@186801|Clostridia,36E6F@31979|Clostridiaceae 186801|Clostridia H PFAM UbiA prenyltransferase ubiA - - - - - - - - - - - UbiA LANLAPFM_00403 585394.RHOM_11975 2.91e-130 397.0 28PI9@1|root,2ZC8C@2|Bacteria,1V6ZI@1239|Firmicutes,24M4V@186801|Clostridia 186801|Clostridia S Glucosyl transferase GtrII - - - - - - - - - - - - Glucos_trans_II LANLAPFM_00404 1235793.C809_03429 5.82e-85 266.0 2DBCR@1|root,2Z8FA@2|Bacteria,1V8ZT@1239|Firmicutes,24KB5@186801|Clostridia,27MF2@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00405 489825.LYNGBM3L_09380 7.06e-16 84.7 2C7E6@1|root,32JF5@2|Bacteria,1G9FH@1117|Cyanobacteria,1HG1Y@1150|Oscillatoriales 1117|Cyanobacteria - - - - - - - - - - - - - - - LANLAPFM_00406 585394.RHOM_12020 4.37e-59 201.0 COG3274@1|root,COG3274@2|Bacteria,1V90B@1239|Firmicutes,24IC7@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Acyl_transf_3 LANLAPFM_00407 877424.ATWC01000003_gene1798 1.96e-27 119.0 COG3274@1|root,COG3274@2|Bacteria,1VFZD@1239|Firmicutes,25D9I@186801|Clostridia 186801|Clostridia S Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 LANLAPFM_00408 626369.HMPREF0446_00571 2.88e-27 117.0 COG0438@1|root,COG0438@2|Bacteria,1UZFG@1239|Firmicutes,4ISTK@91061|Bacilli 91061|Bacilli M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - LANLAPFM_00411 585394.RHOM_12090 2.86e-201 564.0 COG1470@1|root,COG1470@2|Bacteria,1TRGE@1239|Firmicutes,24EHG@186801|Clostridia 186801|Clostridia D Protein of unknown function (DUF3048) C-terminal domain - - - - - - - - - - - - DUF3048,DUF3048_C LANLAPFM_00412 397288.C806_01854 1.59e-82 283.0 COG5279@1|root,COG5279@2|Bacteria,1VEK2@1239|Firmicutes,24SMT@186801|Clostridia,27NZA@186928|unclassified Lachnospiraceae 186801|Clostridia D COG3209 Rhs family protein - - - - - - - - - - - - Flg_new,Transglut_core LANLAPFM_00413 585394.RHOM_12095 1.88e-189 530.0 COG0463@1|root,COG0463@2|Bacteria,1TPR3@1239|Firmicutes,248Q5@186801|Clostridia 186801|Clostridia M PFAM Glycosyl transferase family 2 - - - ko:K20534 - - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 LANLAPFM_00414 1410658.JHWI01000034_gene1952 8.88e-178 501.0 COG0463@1|root,COG0463@2|Bacteria,1TPR3@1239|Firmicutes,3VP1J@526524|Erysipelotrichia 526524|Erysipelotrichia M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 LANLAPFM_00415 515620.EUBELI_00113 1.95e-64 201.0 COG2246@1|root,COG2246@2|Bacteria,1VESW@1239|Firmicutes,24QSN@186801|Clostridia,25XGV@186806|Eubacteriaceae 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - GtrA LANLAPFM_00416 585394.RHOM_03215 3.17e-37 125.0 2BX75@1|root,32YCI@2|Bacteria,1VEDY@1239|Firmicutes,24QPW@186801|Clostridia 186801|Clostridia S 'small, acid-soluble spore protein sasP - - ko:K06421 - - - - ko00000 - - - SASP LANLAPFM_00417 585394.RHOM_03145 2.47e-103 301.0 COG0693@1|root,COG0693@2|Bacteria,1V3WB@1239|Firmicutes,24HGU@186801|Clostridia 186801|Clostridia S DJ-1 family yajL - 3.5.1.124 ko:K03152 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI LANLAPFM_00418 585394.RHOM_03140 7.98e-87 257.0 COG2954@1|root,COG2954@2|Bacteria,1V7MS@1239|Firmicutes,24JER@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - CYTH LANLAPFM_00419 585394.RHOM_03135 9.08e-191 540.0 COG2263@1|root,COG2263@2|Bacteria,1TQUZ@1239|Firmicutes,248AM@186801|Clostridia 186801|Clostridia J Psort location Cytoplasmic, score - - - - - - - - - - - - Methyltransf_32 LANLAPFM_00420 622312.ROSEINA2194_00699 3.69e-73 225.0 COG4728@1|root,COG4728@2|Bacteria,1VENJ@1239|Firmicutes,24SFD@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - DUF1653 LANLAPFM_00422 610130.Closa_2435 4.55e-178 512.0 COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,21XK8@1506553|Lachnoclostridium 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH LANLAPFM_00423 397287.C807_00819 4.68e-107 313.0 COG0569@1|root,COG0569@2|Bacteria,1TQ9H@1239|Firmicutes,249C2@186801|Clostridia,27KNA@186928|unclassified Lachnospiraceae 186801|Clostridia P TrkA-N domain ktrA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N LANLAPFM_00424 585394.RHOM_03075 1.38e-193 546.0 COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia 186801|Clostridia C aldo keto reductase - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red,Fer4_17,Fer4_9 LANLAPFM_00425 585394.RHOM_03065 1.11e-121 350.0 COG1102@1|root,COG1102@2|Bacteria,1V1PJ@1239|Firmicutes,24GMN@186801|Clostridia 186801|Clostridia F Psort location Cytoplasmic, score - - - - - - - - - - - - Cytidylate_kin2 LANLAPFM_00426 622312.ROSEINA2194_00695 4.72e-151 426.0 COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia 186801|Clostridia E Abc transporter livF - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran LANLAPFM_00427 622312.ROSEINA2194_00694 7.24e-163 457.0 COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,2490B@186801|Clostridia 186801|Clostridia E Abc transporter livG - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C LANLAPFM_00428 622312.ROSEINA2194_00693 3.19e-206 576.0 COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,248WH@186801|Clostridia 186801|Clostridia E Belongs to the binding-protein-dependent transport system permease family livM - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 LANLAPFM_00429 585394.RHOM_03045 4.99e-179 502.0 COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,2480A@186801|Clostridia 186801|Clostridia E Belongs to the binding-protein-dependent transport system permease family livH - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 LANLAPFM_00430 622312.ROSEINA2194_00691 2.47e-217 608.0 COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia 186801|Clostridia E PFAM Extracellular ligand-binding receptor braC - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 LANLAPFM_00433 592026.GCWU0000282_003027 7.97e-206 587.0 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia 186801|Clostridia P Belongs to the ABC transporter superfamily appF - - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY LANLAPFM_00434 1449050.JNLE01000005_gene4146 4.19e-205 571.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,36DZS@31979|Clostridiaceae 186801|Clostridia P Belongs to the ABC transporter superfamily - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY LANLAPFM_00435 1449050.JNLE01000005_gene4147 6.91e-142 431.0 COG1173@1|root,COG5184@1|root,COG1173@2|Bacteria,COG5184@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,36E1E@31979|Clostridiaceae 186801|Clostridia EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N,RCC1_2 LANLAPFM_00436 592026.GCWU0000282_003030 1.44e-137 400.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component appB - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 LANLAPFM_00437 1449050.JNLE01000005_gene4149 7.3e-165 493.0 COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,36WU1@31979|Clostridiaceae 186801|Clostridia E Extracellular solute-binding protein, family 5 - - - ko:K02035,ko:K15584 ko02010,ko02024,map02010,map02024 M00239,M00440 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 LANLAPFM_00438 585394.RHOM_07825 3.67e-125 360.0 COG0740@1|root,COG0740@2|Bacteria,1TPX2@1239|Firmicutes,249QX@186801|Clostridia 186801|Clostridia OU Protease subunit of ATP-dependent tepA - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease LANLAPFM_00439 585394.RHOM_07820 8e-150 428.0 COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia 186801|Clostridia V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA LANLAPFM_00440 585394.RHOM_07815 0.0 1089.0 COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,247KM@186801|Clostridia 186801|Clostridia D FtsK SpoIIIE ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma LANLAPFM_00441 585394.RHOM_07810 0.0 1000.0 COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia 186801|Clostridia H Belongs to the formate--tetrahydrofolate ligase family fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS LANLAPFM_00442 622312.ROSEINA2194_03801 7.8e-95 295.0 COG0457@1|root,COG0457@2|Bacteria,1UZDE@1239|Firmicutes,2491Z@186801|Clostridia 186801|Clostridia S Tetratricopeptide repeat protein - - - - - - - - - - - - CHB_HEX_C_1,Fn3_assoc,TPR_16,TPR_19,TPR_8,zinc_ribbon_2 LANLAPFM_00443 622312.ROSEINA2194_03792 1.06e-103 303.0 COG0503@1|root,COG0503@2|Bacteria,1V1DU@1239|Firmicutes,249VC@186801|Clostridia 186801|Clostridia F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis xpt - 2.4.2.22 ko:K03816 ko00230,ko01100,ko01110,map00230,map01100,map01110 - R01229,R02142 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran LANLAPFM_00445 585394.RHOM_07785 6.69e-81 243.0 COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,24HED@186801|Clostridia 186801|Clostridia J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase LANLAPFM_00446 1280390.CBQR020000002_gene18 1.63e-190 548.0 COG3507@1|root,COG3507@2|Bacteria,1UY12@1239|Firmicutes,4HEUT@91061|Bacilli,27497@186822|Paenibacillaceae 91061|Bacilli G Belongs to the glycosyl hydrolase 43 family - - 3.2.1.37,3.2.1.55 ko:K01198,ko:K01209 ko00520,ko01100,map00520,map01100 - R01433,R01762 RC00467 ko00000,ko00001,ko01000 - GH43,GH51 - Glyco_hydro_43 LANLAPFM_00447 1256908.HMPREF0373_02751 6.65e-290 800.0 COG0591@1|root,COG0591@2|Bacteria,1TPVE@1239|Firmicutes,248NQ@186801|Clostridia,25V4N@186806|Eubacteriaceae 186801|Clostridia E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family putP - - ko:K11928 - - - - ko00000,ko02000 2.A.21.2 - - SSF LANLAPFM_00448 585394.RHOM_04730 1.48e-273 753.0 COG4908@1|root,COG4908@2|Bacteria,1TQXH@1239|Firmicutes,24B2C@186801|Clostridia 186801|Clostridia I Psort location - - - - - - - - - - - - AATase LANLAPFM_00449 585394.RHOM_04735 4.16e-110 322.0 2B3FQ@1|root,31W4P@2|Bacteria,1V6XF@1239|Firmicutes,24KDR@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - LANLAPFM_00450 585394.RHOM_04740 1.93e-195 545.0 COG0657@1|root,COG0657@2|Bacteria,1UZ7B@1239|Firmicutes,25B2C@186801|Clostridia 186801|Clostridia I Psort location Cytoplasmic, score - - 3.1.1.83 ko:K14731 ko00903,ko00930,ko01220,map00903,map00930,map01220 - R03751,R06390,R06391,R06392,R06393 RC00713,RC00983,RC01505 ko00000,ko00001,ko01000 - - - Abhydrolase_3 LANLAPFM_00451 585394.RHOM_04745 7.58e-257 709.0 COG0205@1|root,COG0205@2|Bacteria,1TRJQ@1239|Firmicutes,247IV@186801|Clostridia 186801|Clostridia H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK LANLAPFM_00452 585394.RHOM_04750 1.41e-161 458.0 COG1313@1|root,COG1313@2|Bacteria,1TRUV@1239|Firmicutes,247VW@186801|Clostridia 186801|Clostridia C radical SAM domain protein PflX - 1.97.1.4 ko:K04070 - - - - ko00000,ko01000 - - - Fer4_12,Fer4_14,Radical_SAM LANLAPFM_00453 622312.ROSEINA2194_03438 1.71e-21 105.0 COG5184@1|root,COG5184@2|Bacteria,1VDTD@1239|Firmicutes,25FD2@186801|Clostridia 186801|Clostridia DZ Cadherin-like beta sandwich domain - - - - - - - - - - - - Cadherin-like LANLAPFM_00454 622312.ROSEINA2194_03436 0.0 1234.0 COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia 186801|Clostridia O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N LANLAPFM_00455 585394.RHOM_04785 9.41e-75 225.0 2AU16@1|root,31JM9@2|Bacteria,1V6CJ@1239|Firmicutes,24JBF@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - LANLAPFM_00456 585394.RHOM_09600 2.34e-253 697.0 COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia 186801|Clostridia C Malic enzyme, NAD binding domain maeB - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic LANLAPFM_00457 585394.RHOM_09605 1.66e-166 471.0 COG1242@1|root,COG1242@2|Bacteria,1TQ57@1239|Firmicutes,247U3@186801|Clostridia 186801|Clostridia S radical SAM protein, TIGR01212 family ytqA - - ko:K07139 - - - - ko00000 - - - Radical_SAM,Radical_SAM_C LANLAPFM_00458 585394.RHOM_09610 3.79e-100 292.0 COG3432@1|root,COG3432@2|Bacteria,1V75P@1239|Firmicutes,24JAZ@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF4364 LANLAPFM_00459 585394.RHOM_09615 2.13e-116 338.0 COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia 186801|Clostridia V Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - - - - - - - - - - Flavin_Reduct LANLAPFM_00460 585394.RHOM_09630 0.0 916.0 COG1164@1|root,COG1164@2|Bacteria,1TPV4@1239|Firmicutes,2495D@186801|Clostridia 186801|Clostridia E oligoendopeptidase, M3 family - - - - - - - - - - - - Peptidase_M3 LANLAPFM_00461 585394.RHOM_09640 2.89e-116 352.0 28JJA@1|root,2Z9CD@2|Bacteria,1TPY4@1239|Firmicutes,24DSP@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00462 585394.RHOM_03580 7.12e-168 478.0 COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,247K8@186801|Clostridia 186801|Clostridia G ABC-type sugar transport system periplasmic component - - - ko:K02058 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - Peripla_BP_4 LANLAPFM_00463 585394.RHOM_03570 1.05e-214 596.0 COG1172@1|root,COG1172@2|Bacteria,1TPPT@1239|Firmicutes,248FJ@186801|Clostridia 186801|Clostridia G Belongs to the binding-protein-dependent transport system permease family yjfF - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 LANLAPFM_00464 585394.RHOM_03565 5.86e-220 610.0 COG1172@1|root,COG1172@2|Bacteria,1TR6F@1239|Firmicutes,2484T@186801|Clostridia 186801|Clostridia G Belongs to the binding-protein-dependent transport system permease family - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 LANLAPFM_00465 585394.RHOM_03560 0.0 887.0 COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia 186801|Clostridia G import. Responsible for energy coupling to the transport system araG_1 - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran LANLAPFM_00466 585394.RHOM_03555 4.55e-212 592.0 COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,247K8@186801|Clostridia 186801|Clostridia G ABC-type sugar transport system periplasmic component - - - ko:K02058 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - Peripla_BP_4 LANLAPFM_00467 585394.RHOM_08465 3.3e-48 154.0 COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia 186801|Clostridia J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 LANLAPFM_00468 585394.RHOM_08470 5.9e-165 476.0 COG0791@1|root,COG3103@1|root,COG0791@2|Bacteria,COG3103@2|Bacteria,COG4991@2|Bacteria,1UBS0@1239|Firmicutes,25B2D@186801|Clostridia 186801|Clostridia M NlpC p60 family protein - - - - - - - - - - - - NLPC_P60,SH3_3 LANLAPFM_00469 585394.RHOM_08475 3.32e-171 483.0 COG0196@1|root,COG0196@2|Bacteria,1TPKS@1239|Firmicutes,2484A@186801|Clostridia 186801|Clostridia H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase LANLAPFM_00470 622312.ROSEINA2194_00453 4.87e-156 446.0 COG0130@1|root,COG0130@2|Bacteria,1TP9Y@1239|Firmicutes,24B46@186801|Clostridia 186801|Clostridia J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N LANLAPFM_00471 585394.RHOM_08485 2.73e-167 474.0 COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia 186801|Clostridia J domain protein nrnA - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 LANLAPFM_00472 622312.ROSEINA2194_00455 5.93e-66 202.0 COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia 186801|Clostridia J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA LANLAPFM_00473 585394.RHOM_08495 0.0 1234.0 COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia 186801|Clostridia J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N LANLAPFM_00474 585394.RHOM_08500 1.52e-51 164.0 COG1358@1|root,COG1358@2|Bacteria,1VEYG@1239|Firmicutes,24QP3@186801|Clostridia 186801|Clostridia J ribosomal protein - - - - - - - - - - - - Ribosomal_L7Ae LANLAPFM_00475 585394.RHOM_08505 1.74e-49 158.0 COG2740@1|root,COG2740@2|Bacteria,1VEJS@1239|Firmicutes,24QSJ@186801|Clostridia 186801|Clostridia K Nucleic-acid-binding protein implicated in transcription termination ylxR - - ko:K07742 - - - - ko00000 - - - DUF448 LANLAPFM_00476 585394.RHOM_08510 1.18e-232 647.0 COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,247W8@186801|Clostridia 186801|Clostridia K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_5,NusA_N,S1 LANLAPFM_00477 585394.RHOM_08515 5.44e-99 288.0 COG0779@1|root,COG0779@2|Bacteria,1V6KT@1239|Firmicutes,24N1G@186801|Clostridia 186801|Clostridia S Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C LANLAPFM_00479 585394.RHOM_07830 0.0 922.0 COG0297@1|root,COG0297@2|Bacteria,1TQ4M@1239|Firmicutes,248G1@186801|Clostridia 186801|Clostridia G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 LANLAPFM_00480 585394.RHOM_07835 4.31e-150 424.0 COG0217@1|root,COG0217@2|Bacteria,1TPP5@1239|Firmicutes,247NK@186801|Clostridia 186801|Clostridia K transcriptional regulatory protein yebC - - - - - - - - - - - Transcrip_reg LANLAPFM_00481 585394.RHOM_07845 2.16e-70 213.0 COG2337@1|root,COG2337@2|Bacteria,1V6DK@1239|Firmicutes,24JE1@186801|Clostridia 186801|Clostridia L Toxic component of a toxin-antitoxin (TA) module ndoA - - ko:K07171 - - - - ko00000,ko01000,ko02048 - - - PemK_toxin LANLAPFM_00482 622312.ROSEINA2194_03813 6.25e-212 593.0 COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia 186801|Clostridia M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N LANLAPFM_00483 585394.RHOM_07850 1.24e-176 513.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia 186801|Clostridia H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - ACPS,Carb_kinase,YjeF_N LANLAPFM_00484 585394.RHOM_07855 1.53e-137 391.0 COG2344@1|root,COG2344@2|Bacteria,1TSMR@1239|Firmicutes,247RQ@186801|Clostridia 186801|Clostridia K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex - - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N LANLAPFM_00485 585394.RHOM_07860 5.48e-68 226.0 COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia 186801|Clostridia S Abc transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn LANLAPFM_00486 585394.RHOM_07860 1.84e-255 717.0 COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia 186801|Clostridia S Abc transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn LANLAPFM_00487 585394.RHOM_07865 5.04e-278 761.0 COG0538@1|root,COG0538@2|Bacteria,1TSKB@1239|Firmicutes,247KX@186801|Clostridia 186801|Clostridia C Belongs to the isocitrate and isopropylmalate dehydrogenases family icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh LANLAPFM_00488 585394.RHOM_07870 3.78e-126 362.0 COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,24E6I@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - FCD,GntR LANLAPFM_00489 585394.RHOM_07875 0.0 923.0 COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2495J@186801|Clostridia 186801|Clostridia E Belongs to the alpha-IPM synthase homocitrate synthase family - GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0036440,GO:0046912,GO:0050450 - - - - - - - - - iHN637.CLJU_RS03250 HMGL-like LANLAPFM_00491 585394.RHOM_04825 0.0 1023.0 COG0488@1|root,COG0488@2|Bacteria,1TPW0@1239|Firmicutes,248ST@186801|Clostridia 186801|Clostridia S ABC transporter ykpA - - - - - - - - - - - ABC_tran,ABC_tran_Xtn LANLAPFM_00492 585394.RHOM_04830 0.0 1104.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1TS8B@1239|Firmicutes,24EZ4@186801|Clostridia 186801|Clostridia T GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_3,SBP_bac_3 LANLAPFM_00493 622312.ROSEINA2194_04145 0.0 2296.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia 186801|Clostridia C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C LANLAPFM_00494 622312.ROSEINA2194_04143 0.0 912.0 COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia 186801|Clostridia G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsP - 2.7.3.9,2.7.9.2 ko:K01007,ko:K08483 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C LANLAPFM_00495 622312.ROSEINA2194_04142 1.56e-46 150.0 COG1925@1|root,COG1925@2|Bacteria 2|Bacteria G phosphoenolpyruvate-dependent sugar phosphotransferase system ptsH - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr LANLAPFM_00496 457412.RSAG_02981 6.08e-201 562.0 COG0582@1|root,COG0582@2|Bacteria,1TSQW@1239|Firmicutes,249T6@186801|Clostridia,3WHU5@541000|Ruminococcaceae 186801|Clostridia L Phage integrase family - - - - - - - - - - - - Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase LANLAPFM_00497 1235800.C819_01131 1.16e-19 90.9 28J9U@1|root,2Z94P@2|Bacteria,1UYN9@1239|Firmicutes,248AD@186801|Clostridia,27PA2@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00498 1410633.JHWR01000016_gene1040 1.61e-84 251.0 COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,24FRS@186801|Clostridia,27M62@186928|unclassified Lachnospiraceae 186801|Clostridia H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH - 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase LANLAPFM_00499 1321778.HMPREF1982_03317 1.36e-241 669.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,248B0@186801|Clostridia,26AE5@186813|unclassified Clostridiales 186801|Clostridia H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 LANLAPFM_00500 1341157.RF007C_08915 1.53e-88 266.0 COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,24FVK@186801|Clostridia,3WIGR@541000|Ruminococcaceae 186801|Clostridia H riboflavin synthase, alpha subunit ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding LANLAPFM_00501 1321778.HMPREF1982_03315 1.37e-159 458.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,26A16@186813|unclassified Clostridiales 186801|Clostridia H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 LANLAPFM_00502 877424.ATWC01000015_gene635 5.38e-266 770.0 COG0642@1|root,COG0784@1|root,COG1307@1|root,COG0784@2|Bacteria,COG1307@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,27I9U@186928|unclassified Lachnospiraceae 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - DegV,HATPase_c,HisKA,Hpt,Response_reg LANLAPFM_00503 877424.ATWC01000015_gene634 2.02e-202 607.0 COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1TSDF@1239|Firmicutes,250SJ@186801|Clostridia,27ISK@186928|unclassified Lachnospiraceae 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - 4HB_MCP_1,GAF_2,HATPase_c,HisKA,Hpt,Response_reg LANLAPFM_00509 585394.RHOM_05235 5.18e-15 72.4 2EG0W@1|root,339SX@2|Bacteria,1VKDR@1239|Firmicutes,24S7Y@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00510 585394.RHOM_05230 9.83e-138 413.0 28I5Y@1|root,2Z892@2|Bacteria,1UYUF@1239|Firmicutes,24CM9@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00511 585394.RHOM_05225 1.42e-181 513.0 COG0630@1|root,COG0630@2|Bacteria,1UHT2@1239|Firmicutes,25EN1@186801|Clostridia 186801|Clostridia NU COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis - - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE LANLAPFM_00520 1462527.CCDM010000002_gene1665 3.73e-22 94.0 COG1476@1|root,COG1476@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - Cupin_2,HTH_3 LANLAPFM_00522 476272.RUMHYD_02827 1.53e-20 83.6 COG1974@1|root,COG1974@2|Bacteria 2|Bacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair - - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - HTH_3,LexA_DNA_bind,Peptidase_S24 LANLAPFM_00523 476272.RUMHYD_02826 2.57e-35 125.0 COG1476@1|root,COG1476@2|Bacteria,1VGN2@1239|Firmicutes,24T4H@186801|Clostridia 186801|Clostridia K TRANSCRIPTIONal - - - - - - - - - - - - - LANLAPFM_00524 476272.RUMHYD_02826 1.62e-53 171.0 COG1476@1|root,COG1476@2|Bacteria,1VGN2@1239|Firmicutes,24T4H@186801|Clostridia 186801|Clostridia K TRANSCRIPTIONal - - - - - - - - - - - - - LANLAPFM_00525 585394.RHOM_13905 0.0 1196.0 COG0119@1|root,COG2207@1|root,COG0119@2|Bacteria,COG2207@2|Bacteria,1TP4Y@1239|Firmicutes,2485A@186801|Clostridia 186801|Clostridia E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,HTH_18,LeuA_dimer LANLAPFM_00526 471875.RUMLAC_00843 1.91e-62 197.0 28PZ1@1|root,2ZCII@2|Bacteria,1V2GX@1239|Firmicutes,24IE1@186801|Clostridia,3WK3Z@541000|Ruminococcaceae 186801|Clostridia S Domain of unknown function, E. rectale Gene description (DUF3877) - - - - - - - - - - - - DUF3877 LANLAPFM_00527 622312.ROSEINA2194_00788 6.32e-83 247.0 COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia 186801|Clostridia K transcriptional regulator - - - - - - - - - - - - Rrf2 LANLAPFM_00528 1235793.C809_01839 2.26e-54 171.0 COG3695@1|root,COG3695@2|Bacteria,1UIU9@1239|Firmicutes,25ES2@186801|Clostridia,27UK4@186928|unclassified Lachnospiraceae 186801|Clostridia L 6-O-methylguanine DNA methyltransferase, DNA binding domain - - - ko:K07443 - - - - ko00000 - - - DNA_binding_1 LANLAPFM_00529 622312.ROSEINA2194_00787 3.71e-302 835.0 COG0659@1|root,COG0659@2|Bacteria,1TPI4@1239|Firmicutes,24978@186801|Clostridia 186801|Clostridia P Sulfate transporter sulP - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp LANLAPFM_00531 411461.DORFOR_00949 2.24e-28 111.0 2CJI5@1|root,32SA3@2|Bacteria,1VAH5@1239|Firmicutes,24MTX@186801|Clostridia,27VSK@189330|Dorea 186801|Clostridia S Sporulation and spore germination - - - - - - - - - - - - Germane LANLAPFM_00532 622312.ROSEINA2194_01022 3.22e-78 247.0 COG0789@1|root,COG4978@1|root,COG0789@2|Bacteria,COG4978@2|Bacteria,1V48S@1239|Firmicutes,24F7N@186801|Clostridia 186801|Clostridia KT transcriptional regulator bltR - - - - - - - - - - - GyrI-like,MerR_1 LANLAPFM_00533 622312.ROSEINA2194_01023 5.4e-175 503.0 COG0534@1|root,COG0534@2|Bacteria,1TPPJ@1239|Firmicutes,25AZE@186801|Clostridia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - MatE LANLAPFM_00534 585394.RHOM_13940 1.83e-83 248.0 COG0517@1|root,COG0517@2|Bacteria,1V7XE@1239|Firmicutes,24HF5@186801|Clostridia 186801|Clostridia S Cbs domain - - - - - - - - - - - - CBS LANLAPFM_00536 622312.ROSEINA2194_00543 6.01e-169 479.0 COG0562@1|root,COG0562@2|Bacteria,1TQB9@1239|Firmicutes,249BR@186801|Clostridia 186801|Clostridia M UDP-galactopyranose mutase glf - 5.4.99.9 ko:K01854 ko00052,ko00520,map00052,map00520 - R00505,R09009 RC00317,RC02396 ko00000,ko00001,ko01000 - - - GLF,NAD_binding_8 LANLAPFM_00537 585394.RHOM_11865 7.5e-219 606.0 COG0463@1|root,COG0463@2|Bacteria,1TT6C@1239|Firmicutes,248F2@186801|Clostridia 186801|Clostridia M Psort location Cytoplasmic, score kfoC_2 - - - - - - - - - - - Glycos_transf_2 LANLAPFM_00538 585394.RHOM_11850 4.29e-19 91.7 COG1670@1|root,COG1670@2|Bacteria,1UHY0@1239|Firmicutes,25EFE@186801|Clostridia 186801|Clostridia J Psort location Cytoplasmic, score - - - - - - - - - - - - Acetyltransf_1 LANLAPFM_00539 1235790.C805_02060 7.8e-131 377.0 COG4555@1|root,COG4555@2|Bacteria,1UHYH@1239|Firmicutes,25E73@186801|Clostridia 186801|Clostridia CP ABC transporter natA - 3.6.3.7 ko:K09697 ko02010,ko02020,map02010,map02020 M00253 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.115 - - ABC_tran LANLAPFM_00540 397290.C810_02286 1.88e-123 369.0 COG1668@1|root,COG1668@2|Bacteria,1TQNC@1239|Firmicutes,2489Z@186801|Clostridia,27I77@186928|unclassified Lachnospiraceae 186801|Clostridia CP ABC-2 family transporter protein natB - - ko:K09696 ko02010,ko02020,map02010,map02020 M00253 - - ko00000,ko00001,ko00002,ko02000 3.A.1.115 - - ABC2_membrane_2,ABC2_membrane_3,Abi LANLAPFM_00541 585394.RHOM_11845 7.01e-107 315.0 COG0726@1|root,COG0726@2|Bacteria,1V6DN@1239|Firmicutes,24JSE@186801|Clostridia 186801|Clostridia G xylanase chitin deacetylase - - 3.5.1.104 ko:K22278 - - - - ko00000,ko01000 - - - Polysacc_deac_1 LANLAPFM_00542 622312.ROSEINA2194_02179 4.42e-32 118.0 2E5D8@1|root,33058@2|Bacteria,1VERG@1239|Firmicutes,24S0M@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - DUF1344 LANLAPFM_00543 658086.HMPREF0994_04050 1.82e-117 358.0 COG4826@1|root,COG4826@2|Bacteria,1UYKX@1239|Firmicutes,24B76@186801|Clostridia,27KFI@186928|unclassified Lachnospiraceae 186801|Clostridia O SERine Proteinase INhibitors - - - ko:K13963 ko05146,map05146 - - - ko00000,ko00001 - - - Serpin LANLAPFM_00544 585394.RHOM_03840 3.86e-74 228.0 COG1595@1|root,COG1595@2|Bacteria,1V1JW@1239|Firmicutes,24FYN@186801|Clostridia 186801|Clostridia K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 LANLAPFM_00546 585394.RHOM_04185 7.55e-143 405.0 COG0461@1|root,COG0461@2|Bacteria,1TREW@1239|Firmicutes,248WM@186801|Clostridia 186801|Clostridia F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran LANLAPFM_00547 585394.RHOM_04190 2.71e-62 196.0 COG4767@1|root,COG4767@2|Bacteria,1VAH6@1239|Firmicutes,24MQR@186801|Clostridia 186801|Clostridia V Glycopeptide antibiotics resistance protein - - - - - - - - - - - - VanZ LANLAPFM_00548 1410630.JNKP01000001_gene1787 3.28e-120 351.0 COG0726@1|root,COG0726@2|Bacteria,1U0B6@1239|Firmicutes,24895@186801|Clostridia,27M6G@186928|unclassified Lachnospiraceae 186801|Clostridia G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 LANLAPFM_00549 585394.RHOM_03965 0.0 953.0 COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia 186801|Clostridia F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family ade - 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - Adenine_deam_C,Amidohydro_1 LANLAPFM_00550 585394.RHOM_03960 8.88e-128 379.0 COG4086@1|root,COG4086@2|Bacteria,1TR2I@1239|Firmicutes,24C10@186801|Clostridia 186801|Clostridia S Secreted protein - - - - - - - - - - - - DUF1002 LANLAPFM_00551 585394.RHOM_03955 2.59e-180 507.0 COG2267@1|root,COG2267@2|Bacteria,1TRM1@1239|Firmicutes,247J5@186801|Clostridia 186801|Clostridia I Hydrolase, alpha beta domain protein - - - - - - - - - - - - Hydrolase_4 LANLAPFM_00553 622312.ROSEINA2194_03374 0.0 879.0 COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia 186801|Clostridia L Single-stranded-DNA-specific exonuclease RecJ recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 LANLAPFM_00554 622312.ROSEINA2194_03375 1.69e-113 332.0 COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248GJ@186801|Clostridia 186801|Clostridia J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA1 - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 LANLAPFM_00555 585394.RHOM_03935 1.3e-247 687.0 COG3409@1|root,COG3409@2|Bacteria,1TS29@1239|Firmicutes,247SQ@186801|Clostridia 186801|Clostridia M Peptidoglycan binding domain protein sleC - - - - - - - - - - - PG_binding_1,SpoIID LANLAPFM_00556 622312.ROSEINA2194_03378 0.0 988.0 COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia 186801|Clostridia M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS LANLAPFM_00557 585394.RHOM_00600 8.96e-86 266.0 COG2720@1|root,COG2720@2|Bacteria,1V5AV@1239|Firmicutes,24HJP@186801|Clostridia 186801|Clostridia V vancomycin resistance protein - - - - - - - - - - - - Big_4,CW_binding_2,VanW LANLAPFM_00558 585394.RHOM_15990 8.34e-229 638.0 COG1228@1|root,COG1228@2|Bacteria,1TPNQ@1239|Firmicutes,248UT@186801|Clostridia 186801|Clostridia Q amidohydrolase - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 LANLAPFM_00559 140626.JHWB01000022_gene2044 2.69e-293 812.0 COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia 186801|Clostridia G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsP - 2.7.3.9,2.7.9.2 ko:K01007,ko:K08483 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C LANLAPFM_00560 140626.JHWB01000022_gene2043 3.49e-35 121.0 COG1925@1|root,COG1925@2|Bacteria,1VA0R@1239|Firmicutes,24QIP@186801|Clostridia 186801|Clostridia G phosphocarrier, HPr family - - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr LANLAPFM_00561 622312.ROSEINA2194_04380 0.0 1000.0 COG1299@1|root,COG1445@1|root,COG1762@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,COG1762@2|Bacteria,1TPKU@1239|Firmicutes,248V6@186801|Clostridia 186801|Clostridia G Phosphotransferase System fruA - 2.7.1.202 ko:K02768,ko:K02769,ko:K02770 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_EIIA_2,PTS_EIIC,PTS_IIB LANLAPFM_00562 622312.ROSEINA2194_04379 1.88e-176 496.0 COG1105@1|root,COG1105@2|Bacteria,1TQ36@1239|Firmicutes,249RK@186801|Clostridia 186801|Clostridia H Belongs to the carbohydrate kinase PfkB family. LacC subfamily pfkB - 2.7.1.56 ko:K00882 ko00051,map00051 - R02071 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB LANLAPFM_00563 585394.RHOM_16010 2.88e-137 392.0 COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,2498W@186801|Clostridia 186801|Clostridia K transcriptional regulator DeoR family fruR - - ko:K03436 - - - - ko00000,ko03000 - - - DeoRC,HTH_DeoR LANLAPFM_00564 585394.RHOM_16015 1.46e-73 228.0 COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,24F4A@186801|Clostridia 186801|Clostridia G phosphoglycerate mutase - - 3.1.3.73 ko:K02226 ko00860,ko01100,map00860,map01100 M00122 R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 LANLAPFM_00565 1226325.HMPREF1548_02751 2.11e-74 239.0 28JN4@1|root,2Z9EJ@2|Bacteria,1TRQI@1239|Firmicutes,24E4X@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - Transposase_31 LANLAPFM_00568 622312.ROSEINA2194_03155 6.02e-105 310.0 COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,248E6@186801|Clostridia 186801|Clostridia I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD - 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS20335 IspD LANLAPFM_00569 622312.ROSEINA2194_03156 2.06e-234 646.0 COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia 186801|Clostridia O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 LANLAPFM_00570 585394.RHOM_02890 1.75e-74 229.0 2CB94@1|root,32XMH@2|Bacteria,1VCD1@1239|Firmicutes,24MX5@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00571 622312.ROSEINA2194_03158 1.98e-189 529.0 COG1234@1|root,COG1234@2|Bacteria,1TRGP@1239|Firmicutes,248EQ@186801|Clostridia 186801|Clostridia S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 LANLAPFM_00572 585394.RHOM_02880 7.57e-26 97.4 2EJD6@1|root,33D47@2|Bacteria,1VKED@1239|Firmicutes,24T7S@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_00573 622312.ROSEINA2194_03159 7.09e-72 219.0 COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,24J9Z@186801|Clostridia 186801|Clostridia K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 rimI - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1,Acetyltransf_10 LANLAPFM_00574 622312.ROSEINA2194_03160 1.82e-129 372.0 COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia 186801|Clostridia O Universal bacterial protein YeaZ yeaZ - - ko:K14742 - - - - ko00000,ko03016 - - - Acetyltransf_1,Peptidase_M22 LANLAPFM_00575 622312.ROSEINA2194_03161 9.27e-91 266.0 COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia 186801|Clostridia K Hydrolase, P-loop family ydiB - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE LANLAPFM_00576 622312.ROSEINA2194_03162 2.43e-65 204.0 2AZ5D@1|root,31RC2@2|Bacteria,1V74Z@1239|Firmicutes,24KGW@186801|Clostridia 186801|Clostridia S YcxB-like protein - - - - - - - - - - - - YcxB LANLAPFM_00577 622312.ROSEINA2194_00823 1.66e-113 329.0 COG3601@1|root,COG3601@2|Bacteria,1V4BW@1239|Firmicutes,24E4V@186801|Clostridia 186801|Clostridia S Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins ribU - - - - - - - - - - - ECF_trnsprt LANLAPFM_00578 622312.ROSEINA2194_00824 0.0 1251.0 COG2183@1|root,COG2183@2|Bacteria,1TPFE@1239|Firmicutes,248P0@186801|Clostridia 186801|Clostridia K Tex-like protein N-terminal domain yhgF - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF LANLAPFM_00579 585394.RHOM_02840 9.56e-35 122.0 2EGCD@1|root,33A46@2|Bacteria,1VMG3@1239|Firmicutes,24UKI@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00580 585394.RHOM_02835 3.63e-42 144.0 2DNZJ@1|root,32ZX7@2|Bacteria,1VHMI@1239|Firmicutes,24SBG@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF2752) - - - - - - - - - - - - DUF2752 LANLAPFM_00581 585394.RHOM_02825 4.27e-76 238.0 COG5523@1|root,COG5523@2|Bacteria,1VB3B@1239|Firmicutes,24N6Q@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF975) - - - - - - - - - - - - DUF975 LANLAPFM_00582 585394.RHOM_02820 2.37e-295 811.0 COG2233@1|root,COG2233@2|Bacteria,1TQKX@1239|Firmicutes,2485Z@186801|Clostridia 186801|Clostridia F permease pyrP - - ko:K02824 - - - - ko00000,ko02000 2.A.40.1.1,2.A.40.1.2 - - Xan_ur_permease LANLAPFM_00583 585394.RHOM_02815 1.8e-77 240.0 COG4758@1|root,COG4758@2|Bacteria,1V7WJ@1239|Firmicutes,24A1Z@186801|Clostridia 186801|Clostridia S membrane - - - - - - - - - - - - DUF2154 LANLAPFM_00584 397291.C804_03441 1.9e-71 219.0 COG3279@1|root,COG3279@2|Bacteria,1VBF7@1239|Firmicutes,24G1R@186801|Clostridia,27MWM@186928|unclassified Lachnospiraceae 186801|Clostridia KT LytTr DNA-binding domain - - - - - - - - - - - - LytTR LANLAPFM_00585 585394.RHOM_02805 1.25e-168 475.0 COG0489@1|root,COG0489@2|Bacteria,1TQ34@1239|Firmicutes,24817@186801|Clostridia 186801|Clostridia D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - - - - - - - - - - ParA LANLAPFM_00586 585394.RHOM_02800 4.19e-214 597.0 COG0182@1|root,COG0182@2|Bacteria,1TPDK@1239|Firmicutes,249C5@186801|Clostridia 186801|Clostridia J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B LANLAPFM_00588 1469948.JPNB01000002_gene3250 1.76e-199 562.0 COG1680@1|root,COG1680@2|Bacteria,1UC2C@1239|Firmicutes,24B3Q@186801|Clostridia,36FP4@31979|Clostridiaceae 186801|Clostridia V beta-lactamase - - 3.4.16.4 ko:K21469 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Beta-lactamase LANLAPFM_00589 1280694.AUJQ01000011_gene1768 2.02e-130 391.0 COG0013@1|root,COG0013@2|Bacteria,1TSBZ@1239|Firmicutes,249VN@186801|Clostridia,3NGIB@46205|Pseudobutyrivibrio 186801|Clostridia J tRNA synthetases class II (A) alaXL - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD LANLAPFM_00590 622312.ROSEINA2194_01738 8.77e-174 486.0 COG0703@1|root,COG1605@1|root,COG0703@2|Bacteria,COG1605@2|Bacteria,1VA6Z@1239|Firmicutes,24MQY@186801|Clostridia 186801|Clostridia F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CM_2,SKI LANLAPFM_00591 622312.ROSEINA2194_01737 5.19e-186 524.0 COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,248MN@186801|Clostridia 186801|Clostridia G COG COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component siaP - - ko:K21395 - - - - ko00000,ko02000 2.A.56.1 - - DctP LANLAPFM_00592 622312.ROSEINA2194_01736 2.21e-255 706.0 COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia 186801|Clostridia G Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DctM,DctQ LANLAPFM_00593 622312.ROSEINA2194_01735 6.63e-98 290.0 COG3090@1|root,COG3090@2|Bacteria,1V3PZ@1239|Firmicutes,24HA7@186801|Clostridia 186801|Clostridia G COG COG3090 TRAP-type C4-dicarboxylate transport system, small permease component - - - - - - - - - - - - DctQ LANLAPFM_00594 1408312.JNJS01000001_gene1438 6.75e-139 397.0 COG0710@1|root,COG0710@2|Bacteria,1TSPN@1239|Firmicutes,249EX@186801|Clostridia,3NH3M@46205|Pseudobutyrivibrio 186801|Clostridia E Type I 3-dehydroquinase aroD - 4.2.1.10 ko:K03785 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_I,SKI LANLAPFM_00595 622312.ROSEINA2194_01731 1.43e-259 715.0 COG0477@1|root,COG0477@2|Bacteria,1TS50@1239|Firmicutes,24BE2@186801|Clostridia 186801|Clostridia EGP Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - MFS_1 LANLAPFM_00596 622312.ROSEINA2194_01730 2.24e-204 566.0 COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia 186801|Clostridia E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N LANLAPFM_00597 622312.ROSEINA2194_01729 4.99e-179 502.0 COG0583@1|root,COG0583@2|Bacteria,1TRVX@1239|Firmicutes,24B1W@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_1,LysR_substrate LANLAPFM_00598 622312.ROSEINA2194_01728 2.01e-128 371.0 COG0583@1|root,COG0583@2|Bacteria,1TRVX@1239|Firmicutes,24B1W@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_1,LysR_substrate LANLAPFM_00599 622312.ROSEINA2194_01725 0.0 1282.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia 186801|Clostridia C NADH flavin oxidoreductase NADH oxidase - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 LANLAPFM_00600 622312.ROSEINA2194_01722 7.94e-207 572.0 COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia 186801|Clostridia E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N LANLAPFM_00601 411470.RUMGNA_03147 6.09e-64 199.0 COG0454@1|root,COG0456@2|Bacteria,1VDD6@1239|Firmicutes,24NEN@186801|Clostridia,3Y0NK@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10 LANLAPFM_00602 622312.ROSEINA2194_00591 0.0 1212.0 COG4716@1|root,COG4716@2|Bacteria,1TQZ6@1239|Firmicutes,248TZ@186801|Clostridia 186801|Clostridia S Myosin-crossreactive antigen - - 4.2.1.53 ko:K10254 - - - - ko00000,ko01000 - - - MCRA LANLAPFM_00603 1235800.C819_03126 2.51e-99 291.0 COG1309@1|root,COG1309@2|Bacteria,1UYIP@1239|Firmicutes,249K5@186801|Clostridia,27TME@186928|unclassified Lachnospiraceae 186801|Clostridia K Transcriptional regulator C-terminal region - - - - - - - - - - - - TetR_C_8,TetR_N LANLAPFM_00604 33035.JPJF01000032_gene2180 0.0 951.0 COG3534@1|root,COG3534@2|Bacteria,1TRY9@1239|Firmicutes,2497J@186801|Clostridia,3Y1AY@572511|Blautia 186801|Clostridia G Alpha-L-arabinofuranosidase C-terminus abfA - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C LANLAPFM_00605 33035.JPJF01000032_gene2181 3.15e-165 466.0 COG0395@1|root,COG0395@2|Bacteria,1TT5G@1239|Firmicutes,249MU@186801|Clostridia,3Y17N@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K17236 ko02010,map02010 M00602 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.34 - - BPD_transp_1 LANLAPFM_00606 33035.JPJF01000032_gene2182 2.43e-188 526.0 COG1175@1|root,COG1175@2|Bacteria,1TRSP@1239|Firmicutes,24906@186801|Clostridia,3Y17F@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K17235 ko02010,map02010 M00602 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.34 - - BPD_transp_1 LANLAPFM_00607 33035.JPJF01000032_gene2183 7.92e-269 743.0 COG1653@1|root,COG1653@2|Bacteria,1TS9Z@1239|Firmicutes,2490T@186801|Clostridia 186801|Clostridia G Extracellular solute-binding protein araN - - ko:K17234 ko02010,map02010 M00602 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.34 - - SBP_bac_1,SBP_bac_8 LANLAPFM_00608 33035.JPJF01000032_gene2184 0.0 969.0 COG3533@1|root,COG3533@2|Bacteria,1TNYA@1239|Firmicutes,24841@186801|Clostridia,3Y0XI@572511|Blautia 186801|Clostridia S Beta-L-arabinofuranosidase, GH127 - - - ko:K09955 - - - - ko00000 - - - Glyco_hydro_127 LANLAPFM_00609 585394.RHOM_02185 2.51e-101 306.0 COG2199@1|root,COG2199@2|Bacteria,1UV0N@1239|Firmicutes,24NW2@186801|Clostridia 186801|Clostridia T PAS fold - - - - - - - - - - - - GGDEF,PAS_3 LANLAPFM_00610 585394.RHOM_02190 0.0 1407.0 COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia 186801|Clostridia C Glycine radical pflB - 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like LANLAPFM_00611 622312.ROSEINA2194_02147 6.06e-135 388.0 COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,247NA@186801|Clostridia 186801|Clostridia C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine pflA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM LANLAPFM_00613 585394.RHOM_02215 3.95e-109 315.0 COG1544@1|root,COG1544@2|Bacteria,1V1D5@1239|Firmicutes,24HDH@186801|Clostridia 186801|Clostridia J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase hpf - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosom_S30AE_C,Ribosomal_S30AE LANLAPFM_00614 622312.ROSEINA2194_03042 1.71e-143 412.0 COG1307@1|root,COG1307@2|Bacteria,1TRM7@1239|Firmicutes,247ST@186801|Clostridia 186801|Clostridia T EDD domain protein, DegV family - - - - - - - - - - - - DegV LANLAPFM_00616 622312.ROSEINA2194_02142 1.44e-207 579.0 COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,248CR@186801|Clostridia 186801|Clostridia F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N LANLAPFM_00617 622312.ROSEINA2194_02141 8.92e-254 706.0 COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia 186801|Clostridia M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M LANLAPFM_00618 585394.RHOM_13125 1.6e-146 416.0 COG0204@1|root,COG0204@2|Bacteria,1UMJA@1239|Firmicutes,249AV@186801|Clostridia 186801|Clostridia I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family plsC_1 - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase LANLAPFM_00619 585394.RHOM_14775 2.08e-130 375.0 COG1028@1|root,COG1028@2|Bacteria,1TZY6@1239|Firmicutes,248QZ@186801|Clostridia 186801|Clostridia IQ Oxidoreductase, short chain dehydrogenase reductase family protein - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short,adh_short_C2 LANLAPFM_00620 585394.RHOM_14780 0.0 1229.0 COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 13 family glgX - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 LANLAPFM_00621 33035.JPJF01000028_gene2808 1.69e-126 364.0 COG0235@1|root,COG0235@2|Bacteria,1TS5G@1239|Firmicutes,248NY@186801|Clostridia,3XZRB@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 fucA - 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II LANLAPFM_00622 622312.ROSEINA2194_02025 1.06e-147 429.0 COG4677@1|root,COG4677@2|Bacteria,1UYI6@1239|Firmicutes,24B29@186801|Clostridia 186801|Clostridia G Pectinesterase - - 3.1.1.11 ko:K01051 ko00040,ko01100,map00040,map01100 M00081 R02362 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Pectinesterase LANLAPFM_00623 585394.RHOM_14795 4.8e-20 80.9 2DRBT@1|root,33B4Z@2|Bacteria,1VMZQ@1239|Firmicutes,24UIT@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00624 397291.C804_00046 4.68e-121 360.0 COG1266@1|root,COG1266@2|Bacteria,1UYS2@1239|Firmicutes,24BKW@186801|Clostridia,27KG8@186928|unclassified Lachnospiraceae 186801|Clostridia S CAAX protease self-immunity - - - - - - - - - - - - Abi LANLAPFM_00625 411474.COPEUT_02349 1.4e-103 310.0 COG3868@1|root,COG3868@2|Bacteria,1V4J5@1239|Firmicutes,24GI7@186801|Clostridia 186801|Clostridia M Glycoside-hydrolase family GH114 - - - - - - - - - - - - Glyco_hydro_114 LANLAPFM_00626 411474.COPEUT_00477 2.56e-125 368.0 COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,247X1@186801|Clostridia 186801|Clostridia EG Psort location CytoplasmicMembrane, score - - - - - - - - - - - - EamA LANLAPFM_00628 1226325.HMPREF1548_00628 4.04e-142 405.0 2BGWZ@1|root,32AWW@2|Bacteria,1UGTQ@1239|Firmicutes,25PDC@186801|Clostridia,36RXW@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00629 1235802.C823_05784 1.52e-129 376.0 COG1033@1|root,COG1033@2|Bacteria,1VHSF@1239|Firmicutes,24R7H@186801|Clostridia,25XTN@186806|Eubacteriaceae 186801|Clostridia M YARHG domain - - - - - - - - - - - - YARHG,zinc_ribbon_2 LANLAPFM_00630 1226325.HMPREF1548_05938 2.85e-65 200.0 COG1321@1|root,COG1321@2|Bacteria,1V3IS@1239|Firmicutes,24MSE@186801|Clostridia,36KQ7@31979|Clostridiaceae 186801|Clostridia K iron dependent repressor - - - - - - - - - - - - Fe_dep_repr_C,Fe_dep_repress LANLAPFM_00632 180332.JTGN01000006_gene3154 5.14e-173 496.0 COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia 186801|Clostridia M Cbs domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 LANLAPFM_00634 622312.ROSEINA2194_03131 9.75e-246 679.0 COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia 186801|Clostridia E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 LANLAPFM_00635 622312.ROSEINA2194_03130 2e-92 271.0 COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,24HDD@186801|Clostridia 186801|Clostridia C assembly protein, NifU family nifU - - ko:K04488 - - - - ko00000 - - - NifU_N LANLAPFM_00636 1298920.KI911353_gene3328 2.19e-265 732.0 COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,247XK@186801|Clostridia,21XFB@1506553|Lachnoclostridium 186801|Clostridia E Psort location Cytoplasmic, score 9.98 MET17 - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP LANLAPFM_00637 1341157.RF007C_10565 1.93e-173 489.0 COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,3WG9Z@541000|Ruminococcaceae 186801|Clostridia E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP LANLAPFM_00638 585394.RHOM_13855 2.05e-93 278.0 COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24HHW@186801|Clostridia 186801|Clostridia U Belongs to the peptidase S26 family lepB_1 - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 LANLAPFM_00639 585394.RHOM_13850 1.88e-205 577.0 COG0053@1|root,COG0053@2|Bacteria,1TSGY@1239|Firmicutes,2491V@186801|Clostridia 186801|Clostridia P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer LANLAPFM_00640 877424.ATWC01000015_gene633 9.78e-133 389.0 COG3437@1|root,COG3437@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia,27IRU@186928|unclassified Lachnospiraceae 186801|Clostridia T HD domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg LANLAPFM_00641 585394.RHOM_10905 3.58e-244 691.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia 186801|Clostridia L DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C LANLAPFM_00643 585394.RHOM_10895 7.75e-256 711.0 COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia 186801|Clostridia J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - tRNA_U5-meth_tr LANLAPFM_00644 445973.CLOBAR_00478 3.06e-269 746.0 COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,25RRQ@186804|Peptostreptococcaceae 186801|Clostridia H 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD LANLAPFM_00645 742733.HMPREF9469_01638 2.67e-63 200.0 COG0163@1|root,COG0163@2|Bacteria,1V3JV@1239|Firmicutes,24HE5@186801|Clostridia,220IG@1506553|Lachnoclostridium 186801|Clostridia H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein LANLAPFM_00646 742738.HMPREF9460_00250 6.22e-14 70.1 arCOG04966@1|root,33EHA@2|Bacteria,1VN4X@1239|Firmicutes,24VEA@186801|Clostridia,26C56@186813|unclassified Clostridiales 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00647 1410616.JHXE01000014_gene390 2.68e-139 402.0 COG0583@1|root,COG0583@2|Bacteria,1TQ6Y@1239|Firmicutes,24KGS@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_1,LysR_substrate LANLAPFM_00648 1280680.AUJU01000023_gene2540 5.68e-116 354.0 COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,24ABB@186801|Clostridia,4C1ND@830|Butyrivibrio 186801|Clostridia G MFS/sugar transport protein - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 LANLAPFM_00649 1414720.CBYM010000020_gene2482 2e-180 521.0 COG0657@1|root,COG0657@2|Bacteria,1USHI@1239|Firmicutes,24DIN@186801|Clostridia,36IKW@31979|Clostridiaceae 186801|Clostridia I acetylesterase activity - - - - - - - - - - - - - LANLAPFM_00650 1408306.JHXX01000003_gene1412 9.87e-74 224.0 COG0454@1|root,COG0456@2|Bacteria,1VAJN@1239|Firmicutes,24H93@186801|Clostridia,4BXFH@830|Butyrivibrio 186801|Clostridia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10 LANLAPFM_00652 411463.EUBVEN_02876 5.96e-57 179.0 2C5R4@1|root,2ZC1N@2|Bacteria,1V292@1239|Firmicutes,25CQM@186801|Clostridia,25ZT4@186806|Eubacteriaceae 186801|Clostridia S Transposon-encoded protein TnpV - - - - - - - - - - - - TnpV LANLAPFM_00653 1216362.B437_00875 1.59e-124 361.0 COG0500@1|root,COG2226@2|Bacteria,378H4@32066|Fusobacteria 32066|Fusobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 LANLAPFM_00654 1336241.JAEB01000004_gene516 2.97e-38 132.0 2AUVQ@1|root,2ZI4I@2|Bacteria,1V1YP@1239|Firmicutes,24FSR@186801|Clostridia,25W7C@186806|Eubacteriaceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00655 658655.HMPREF0988_01416 3.88e-71 217.0 2AUVQ@1|root,31KJ2@2|Bacteria,1V1UV@1239|Firmicutes,24H4A@186801|Clostridia,27MKJ@186928|unclassified Lachnospiraceae 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - LANLAPFM_00656 478749.BRYFOR_09858 8.29e-43 143.0 296XG@1|root,2ZU65@2|Bacteria,1V0MN@1239|Firmicutes,24GI1@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF3990 LANLAPFM_00657 1506994.JNLQ01000001_gene263 2.64e-145 415.0 COG2013@1|root,COG2013@2|Bacteria,1TP7N@1239|Firmicutes,249B4@186801|Clostridia,4BZ30@830|Butyrivibrio 186801|Clostridia S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24 LANLAPFM_00658 585394.RHOM_16605 0.0 1341.0 COG3973@1|root,COG3973@2|Bacteria,1TP39@1239|Firmicutes,249IG@186801|Clostridia 186801|Clostridia L DNA helicase - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_19,DUF4968,UvrD-helicase,UvrD_C,UvrD_C_2 LANLAPFM_00659 416870.llmg_1857 5.74e-11 61.2 COG2755@1|root,COG2755@2|Bacteria,1V1CQ@1239|Firmicutes,4HGVZ@91061|Bacilli 91061|Bacilli E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - Lipase_GDSL_2 LANLAPFM_00660 411462.DORLON_01191 2.01e-116 343.0 COG0583@1|root,COG0583@2|Bacteria,1UXFR@1239|Firmicutes,25C6Q@186801|Clostridia 186801|Clostridia K transcriptional regulator - - - ko:K21755 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate LANLAPFM_00661 457412.RSAG_01452 2e-243 678.0 COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,3WGER@541000|Ruminococcaceae 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - MatE LANLAPFM_00662 411469.EUBHAL_00026 0.0 984.0 COG0514@1|root,COG0514@2|Bacteria,1TPN5@1239|Firmicutes,247ZA@186801|Clostridia,25UY4@186806|Eubacteriaceae 186801|Clostridia L ATP-dependent DNA helicase RecQ recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind LANLAPFM_00663 411461.DORFOR_00452 1.92e-286 788.0 COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,27UQI@189330|Dorea 186801|Clostridia P COG COG0733 Na -dependent transporters of the SNF family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF LANLAPFM_00664 585394.RHOM_14880 1.3e-174 498.0 COG0738@1|root,COG0738@2|Bacteria,1TPB5@1239|Firmicutes,24913@186801|Clostridia 186801|Clostridia G Major Facilitator - - - - - - - - - - - - MFS_1 LANLAPFM_00665 1280694.AUJQ01000006_gene775 1.21e-95 307.0 COG2199@1|root,COG2199@2|Bacteria,1V0N3@1239|Firmicutes,24FMU@186801|Clostridia,3NHV9@46205|Pseudobutyrivibrio 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - 7TMR-DISM_7TM,GGDEF,SBP_bac_3 LANLAPFM_00666 411461.DORFOR_02251 1.8e-181 509.0 COG0826@1|root,COG0826@2|Bacteria,1TRX5@1239|Firmicutes,24CTG@186801|Clostridia,27W8Q@189330|Dorea 186801|Clostridia O Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - LANLAPFM_00667 622312.ROSEINA2194_03973 4.14e-131 373.0 2BVFM@1|root,320X7@2|Bacteria,1V984@1239|Firmicutes,24KKJ@186801|Clostridia 186801|Clostridia S ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane_5 LANLAPFM_00668 622312.ROSEINA2194_03083 1.61e-192 535.0 COG1131@1|root,COG1131@2|Bacteria,1TPZR@1239|Firmicutes,247NW@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran LANLAPFM_00669 1235792.C808_03355 1.03e-75 227.0 COG1725@1|root,COG1725@2|Bacteria,1V9ZC@1239|Firmicutes,24NTW@186801|Clostridia,27MSR@186928|unclassified Lachnospiraceae 186801|Clostridia K Bacterial regulatory proteins, gntR family - - - ko:K07979 - - - - ko00000,ko03000 - - - GntR LANLAPFM_00670 585394.RHOM_10150 0.0 1033.0 COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia 186801|Clostridia S Abc transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn LANLAPFM_00671 411468.CLOSCI_03722 1.07e-181 516.0 COG1929@1|root,COG1929@2|Bacteria,1TPSI@1239|Firmicutes,249SH@186801|Clostridia,21Y5G@1506553|Lachnoclostridium 186801|Clostridia G Belongs to the glycerate kinase type-1 family glxK - 2.7.1.165 ko:K00865 ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 - R08572 RC00002,RC00428 ko00000,ko00001,ko01000 - - - Gly_kinase LANLAPFM_00672 622312.ROSEINA2194_02760 8.33e-140 402.0 COG0566@1|root,COG0566@2|Bacteria,1TSUW@1239|Firmicutes,24ACK@186801|Clostridia 186801|Clostridia J Psort location Cytoplasmic, score - - - - - - - - - - - - SpoU_methylase LANLAPFM_00674 1280680.AUJU01000016_gene3966 7.42e-58 197.0 COG0488@1|root,COG0488@2|Bacteria,1TNYS@1239|Firmicutes,248D6@186801|Clostridia,4BYMU@830|Butyrivibrio 186801|Clostridia S ATPases associated with a variety of cellular activities - - - ko:K19350 ko02010,map02010 - - - ko00000,ko00001,ko01504,ko02000 3.A.1.121 - - ABC_tran LANLAPFM_00675 1226325.HMPREF1548_01973 1.98e-22 91.3 COG0488@1|root,COG0488@2|Bacteria,1TNYS@1239|Firmicutes,248D6@186801|Clostridia 186801|Clostridia L ABC transporter - - - ko:K19350 ko02010,map02010 - - - ko00000,ko00001,ko01504,ko02000 3.A.1.121 - - ABC_tran LANLAPFM_00676 585394.RHOM_07290 0.0 1193.0 COG0577@1|root,COG0577@2|Bacteria,1TPHU@1239|Firmicutes,247QW@186801|Clostridia 186801|Clostridia V Efflux ABC transporter, permease protein - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD LANLAPFM_00677 622312.ROSEINA2194_03605 2.28e-159 447.0 COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran LANLAPFM_00678 411462.DORLON_02271 7.05e-10 60.5 28JN4@1|root,2Z9EJ@2|Bacteria,1TRQI@1239|Firmicutes,24E4X@186801|Clostridia,27W4K@189330|Dorea 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - LANLAPFM_00679 585394.RHOM_15945 8.02e-106 314.0 28JN4@1|root,2Z9EJ@2|Bacteria,1TRQI@1239|Firmicutes,24E4X@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_00680 1408306.JHXX01000002_gene3031 9.49e-61 239.0 COG3209@1|root,COG4886@1|root,COG3209@2|Bacteria,COG4886@2|Bacteria,1V44C@1239|Firmicutes,25EA1@186801|Clostridia,4C2BH@830|Butyrivibrio 186801|Clostridia M Leucine rich repeats (6 copies) - - - - - - - - - - - - LRR_5 LANLAPFM_00681 411468.CLOSCI_00849 3.05e-22 87.8 COG1396@1|root,COG1396@2|Bacteria,1UHV9@1239|Firmicutes,25E41@186801|Clostridia,223NI@1506553|Lachnoclostridium 186801|Clostridia K Helix-turn-helix domain - - - - - - - - - - - - HTH_19,HTH_3 LANLAPFM_00682 585394.RHOM_11135 1.05e-46 155.0 2C9RU@1|root,349H4@2|Bacteria,1VYXI@1239|Firmicutes,253A6@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00683 585394.RHOM_11140 5.47e-76 232.0 COG3663@1|root,COG3663@2|Bacteria,1V6GI@1239|Firmicutes,24HD8@186801|Clostridia 186801|Clostridia L COG3663 G T U mismatch-specific DNA glycosylase - - 3.2.2.28 ko:K03649 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG LANLAPFM_00684 585394.RHOM_11145 5.53e-143 413.0 COG1879@1|root,COG1879@2|Bacteria,1UYPR@1239|Firmicutes,248AW@186801|Clostridia 186801|Clostridia G Periplasmic binding protein domain - - - ko:K17213 ko02010,map02010 M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2 - - Peripla_BP_4 LANLAPFM_00685 397290.C810_01607 2.94e-240 687.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,27IZ3@186928|unclassified Lachnospiraceae 186801|Clostridia NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 LANLAPFM_00686 1414720.CBYM010000014_gene2732 2.23e-315 900.0 COG3250@1|root,COG3250@2|Bacteria,1TU92@1239|Firmicutes,248WD@186801|Clostridia,36FQK@31979|Clostridiaceae 186801|Clostridia G Belongs to the glycosyl hydrolase 2 family - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N LANLAPFM_00687 622312.ROSEINA2194_00480 2.56e-206 583.0 COG3864@1|root,COG3864@2|Bacteria,1TSI1@1239|Firmicutes,248YT@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF2201,DUF2201_N LANLAPFM_00688 585394.RHOM_09385 7.56e-75 242.0 2DMDS@1|root,32QT4@2|Bacteria,1UINH@1239|Firmicutes,25EP3@186801|Clostridia 186801|Clostridia S Leucine rich repeats (6 copies) - - - - - - - - - - - - LRR_5 LANLAPFM_00689 411469.EUBHAL_02917 5.8e-144 415.0 COG0523@1|root,COG0523@2|Bacteria,1TQRE@1239|Firmicutes,24B0I@186801|Clostridia,25VJT@186806|Eubacteriaceae 186801|Clostridia S CobW/HypB/UreG, nucleotide-binding domain - - - - - - - - - - - - CobW_C,cobW LANLAPFM_00690 1235802.C823_03877 5.72e-184 526.0 COG2866@1|root,COG3409@1|root,COG2866@2|Bacteria,COG3409@2|Bacteria,1TP3K@1239|Firmicutes,249MT@186801|Clostridia,25WZ3@186806|Eubacteriaceae 186801|Clostridia E Zn_pept - - 3.4.19.11 ko:K01308 - - - - ko00000,ko01000,ko01002 - - - LysM,PG_binding_1,Peptidase_M14 LANLAPFM_00691 1235790.C805_02517 2.3e-151 465.0 COG4188@1|root,COG4188@2|Bacteria,1UGK7@1239|Firmicutes,24CXP@186801|Clostridia 186801|Clostridia S dienelactone hydrolase - - - - - - - - - - - - Chlorophyllase2 LANLAPFM_00692 585394.RHOM_13045 5.02e-276 776.0 COG1609@1|root,COG2199@1|root,COG1609@2|Bacteria,COG3706@2|Bacteria,1TSMK@1239|Firmicutes,24EJV@186801|Clostridia 186801|Clostridia KT diguanylate cyclase - - - - - - - - - - - - GGDEF,Peripla_BP_3 LANLAPFM_00693 622312.ROSEINA2194_01540 5.61e-127 361.0 COG0231@1|root,COG0231@2|Bacteria,1TR8P@1239|Firmicutes,249DV@186801|Clostridia 186801|Clostridia J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C LANLAPFM_00694 585394.RHOM_05110 1.21e-94 276.0 COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia 186801|Clostridia G Ribose 5-phosphate isomerase rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB LANLAPFM_00695 585394.RHOM_05105 7.28e-101 294.0 COG2179@1|root,COG2179@2|Bacteria,1V6KM@1239|Firmicutes,24KK7@186801|Clostridia 186801|Clostridia F HAD superfamily (Subfamily IIIA) phosphatase, TIGR01668 yqeG - - ko:K07015 - - - - ko00000 - - - HAD_2,Hydrolase,Hydrolase_like,PGP_phosphatase LANLAPFM_00696 585394.RHOM_05100 1.05e-31 115.0 2E9G7@1|root,333PE@2|Bacteria,1VHIP@1239|Firmicutes,24UC4@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00697 585394.RHOM_05095 7.84e-101 292.0 COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,24HFT@186801|Clostridia 186801|Clostridia K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone LANLAPFM_00698 585394.RHOM_05090 1.43e-43 142.0 COG1873@1|root,COG1873@2|Bacteria,1VEMT@1239|Firmicutes 1239|Firmicutes S sporulation protein, YlmC YmxH family ylmC - - - - - - - - - - - PRC LANLAPFM_00699 585394.RHOM_05085 4.26e-251 690.0 COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,2482Z@186801|Clostridia 186801|Clostridia J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C LANLAPFM_00700 585394.RHOM_09975 7.81e-89 268.0 COG1564@1|root,COG1564@2|Bacteria,1VA0W@1239|Firmicutes,24NG6@186801|Clostridia 186801|Clostridia H thiamine pyrophosphokinase thiN - 2.7.6.2 ko:K00949 ko00730,ko01100,map00730,map01100 - R00619 RC00002,RC00017 ko00000,ko00001,ko01000 - - - TPK_B1_binding,TPK_catalytic LANLAPFM_00701 585394.RHOM_09980 3.28e-128 367.0 COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia 186801|Clostridia G Belongs to the ribulose-phosphate 3-epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim LANLAPFM_00702 585394.RHOM_09985 3.53e-161 457.0 COG1162@1|root,COG1162@2|Bacteria,1TPSQ@1239|Firmicutes,248R5@186801|Clostridia 186801|Clostridia S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase,RsgA_N LANLAPFM_00703 585394.RHOM_09990 7.26e-285 803.0 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia 186801|Clostridia KLT serine threonine protein kinase prkC - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase LANLAPFM_00704 622312.ROSEINA2194_03525 2.75e-126 365.0 COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia 186801|Clostridia T Phosphatase stp - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 LANLAPFM_00705 622312.ROSEINA2194_03526 1.79e-211 588.0 COG0820@1|root,COG0820@2|Bacteria,1TPVF@1239|Firmicutes,248BC@186801|Clostridia 186801|Clostridia J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM LANLAPFM_00706 622312.ROSEINA2194_03527 1.14e-201 572.0 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,248CS@186801|Clostridia 186801|Clostridia J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB LANLAPFM_00707 622312.ROSEINA2194_03528 1.22e-142 405.0 COG2738@1|root,COG2738@2|Bacteria,1TPD3@1239|Firmicutes,2490Y@186801|Clostridia 186801|Clostridia S zinc metallopeptidase yugP - - ko:K06973 - - - - ko00000 - - - Zn_peptidase_2 LANLAPFM_00708 585394.RHOM_10015 5.63e-178 501.0 COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,248ED@186801|Clostridia 186801|Clostridia J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N LANLAPFM_00709 622312.ROSEINA2194_03530 6.49e-92 271.0 COG0242@1|root,COG0242@2|Bacteria,1V70B@1239|Firmicutes,24JET@186801|Clostridia 186801|Clostridia J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase LANLAPFM_00710 585394.RHOM_10025 0.0 1031.0 COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia 186801|Clostridia L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII LANLAPFM_00711 585394.RHOM_10030 1.58e-219 623.0 COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia 186801|Clostridia M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M LANLAPFM_00712 585394.RHOM_10035 2.14e-65 201.0 COG4905@1|root,COG4905@2|Bacteria,1VAQJ@1239|Firmicutes,24K5I@186801|Clostridia 186801|Clostridia S Putative ABC-transporter type IV - - - - - - - - - - - - ABC_trans_CmpB LANLAPFM_00713 585394.RHOM_10045 1.34e-200 557.0 COG0540@1|root,COG0540@2|Bacteria,1TQ96@1239|Firmicutes,2496D@186801|Clostridia 186801|Clostridia F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N,PyrI_C LANLAPFM_00714 585394.RHOM_10050 5.15e-90 265.0 COG1781@1|root,COG1781@2|Bacteria,1V6U9@1239|Firmicutes,24JJU@186801|Clostridia 186801|Clostridia F Aspartate carbamoyltransferase regulatory chain, allosteric domain protein pyrI - - ko:K00610 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002 - - - PyrI,PyrI_C LANLAPFM_00715 622312.ROSEINA2194_03538 2.51e-119 344.0 COG0484@1|root,COG0484@2|Bacteria,1V1GK@1239|Firmicutes,2494E@186801|Clostridia 186801|Clostridia O DnaJ domain protein - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,TPR_2 LANLAPFM_00716 622312.ROSEINA2194_03539 1.44e-167 473.0 2CC4I@1|root,2Z8PZ@2|Bacteria,1TQTT@1239|Firmicutes,24AJ3@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_00717 622312.ROSEINA2194_03540 1.41e-54 174.0 COG4416@1|root,COG4416@2|Bacteria,1VEMD@1239|Firmicutes,24MRR@186801|Clostridia 186801|Clostridia S COG NOG18757 non supervised orthologous group - - - - - - - - - - - - - LANLAPFM_00718 585394.RHOM_04945 0.0 897.0 COG0441@1|root,COG0572@1|root,COG0441@2|Bacteria,COG0572@2|Bacteria,1TQ4V@1239|Firmicutes,249IT@186801|Clostridia 186801|Clostridia F uridine kinase udk - 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PRK LANLAPFM_00719 585394.RHOM_04940 1.04e-94 285.0 COG2384@1|root,COG2384@2|Bacteria,1V3I4@1239|Firmicutes,24BJI@186801|Clostridia 186801|Clostridia L Psort location Cytoplasmic, score trmK - 2.1.1.217 ko:K06967 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_18,TrmK LANLAPFM_00720 585394.RHOM_04935 3.69e-239 663.0 COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia 186801|Clostridia K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth sigA - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 LANLAPFM_00721 622312.ROSEINA2194_03431 0.0 934.0 COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia 186801|Clostridia L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 LANLAPFM_00722 585394.RHOM_04925 4.15e-216 599.0 COG0232@1|root,COG0232@2|Bacteria,1TPEI@1239|Firmicutes,247Q1@186801|Clostridia 186801|Clostridia F Belongs to the dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc LANLAPFM_00724 1235790.C805_01468 1.72e-72 233.0 COG1527@1|root,COG1527@2|Bacteria,1U1QE@1239|Firmicutes,24A4E@186801|Clostridia 186801|Clostridia C Archaeal vacuolar-type H -ATPase subunit C ntpC - - ko:K02119 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_AC39 LANLAPFM_00725 397288.C806_01355 6.26e-255 723.0 COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia,27KFU@186928|unclassified Lachnospiraceae 186801|Clostridia U V-type ATPase 116kDa subunit family ntpI - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I LANLAPFM_00726 397290.C810_03102 7.44e-57 180.0 COG0636@1|root,COG0636@2|Bacteria,1VAGE@1239|Firmicutes,24RB6@186801|Clostridia,27MUF@186928|unclassified Lachnospiraceae 186801|Clostridia C ATP synthase subunit C - - - ko:K02124 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_C LANLAPFM_00727 397288.C806_01357 2.68e-49 158.0 COG1436@1|root,COG1436@2|Bacteria,1VEN1@1239|Firmicutes,24K2E@186801|Clostridia,27NKU@186928|unclassified Lachnospiraceae 186801|Clostridia C ATP synthase (F/14-kDa) subunit - - - ko:K02122 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_F LANLAPFM_00728 357809.Cphy_3443 1.99e-21 94.0 COG1390@1|root,COG1390@2|Bacteria,1V7UJ@1239|Firmicutes,24ICM@186801|Clostridia,21Z0G@1506553|Lachnoclostridium 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - vATP-synt_E LANLAPFM_00729 397288.C806_01359 0.0 930.0 COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,27IS3@186928|unclassified Lachnospiraceae 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit ntpA - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn LANLAPFM_00730 1235790.C805_01474 2.4e-273 754.0 COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia,25VDA@186806|Eubacteriaceae 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit ntpB - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N LANLAPFM_00731 1235790.C805_01475 1.76e-103 304.0 COG1394@1|root,COG1394@2|Bacteria,1TQ4P@1239|Firmicutes,24Z7J@186801|Clostridia,25WFD@186806|Eubacteriaceae 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane atpD - - ko:K02120 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_D LANLAPFM_00732 1235800.C819_00237 9.73e-174 498.0 COG3434@1|root,COG3434@2|Bacteria,1TPWC@1239|Firmicutes,248M1@186801|Clostridia,27J37@186928|unclassified Lachnospiraceae 186801|Clostridia T HDOD domain - - - - - - - - - - - - EAL,HDOD LANLAPFM_00733 556261.HMPREF0240_03651 2.06e-284 792.0 COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,36EBZ@31979|Clostridiaceae 186801|Clostridia J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr LANLAPFM_00734 585394.RHOM_01085 6.27e-203 564.0 COG3481@1|root,COG3481@2|Bacteria,1TPIU@1239|Firmicutes,248SS@186801|Clostridia 186801|Clostridia S domain protein yhaM - - ko:K03698 - - - - ko00000,ko01000,ko03019 - - - HD,tRNA_anti-codon LANLAPFM_00735 585394.RHOM_01080 1.89e-180 520.0 COG0265@1|root,COG0265@2|Bacteria,1TTAZ@1239|Firmicutes,24BWH@186801|Clostridia 186801|Clostridia O PDZ DHR GLGF domain protein - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 LANLAPFM_00736 585394.RHOM_01075 0.0 1196.0 COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,248YK@186801|Clostridia 186801|Clostridia L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr LANLAPFM_00737 622312.ROSEINA2194_02099 1e-153 433.0 COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia 186801|Clostridia T response regulator receiver srrA_2 - - - - - - - - - - - Response_reg,Trans_reg_C LANLAPFM_00738 585394.RHOM_01065 4.73e-274 758.0 COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA LANLAPFM_00739 1280698.AUJS01000002_gene2684 3.69e-113 334.0 COG1361@1|root,COG1361@2|Bacteria,1V003@1239|Firmicutes,24B4Q@186801|Clostridia 186801|Clostridia M Conserved repeat protein - - - - - - - - - - - - - LANLAPFM_00740 1235790.C805_00256 3.49e-77 259.0 COG0726@1|root,COG0726@2|Bacteria,1V6DN@1239|Firmicutes,249SN@186801|Clostridia,25ZE3@186806|Eubacteriaceae 186801|Clostridia G Polysaccharide deacetylase - - 3.5.1.104 ko:K22278 - - - - ko00000,ko01000 - - - CW_binding_1,ChW,Polysacc_deac_1 LANLAPFM_00741 411489.CLOL250_01602 1.07e-300 888.0 COG3210@1|root,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - 3.2.1.78 ko:K01218 ko00051,ko02024,map00051,map02024 - R01332 RC00467 ko00000,ko00001,ko01000 - GH26 - DUF4157,Haemagg_act,LRR_5,Peptidase_M64 LANLAPFM_00746 585394.RHOM_03550 4.23e-241 675.0 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia 186801|Clostridia T Histidine kinase - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,His_kinase LANLAPFM_00747 585394.RHOM_03545 8.43e-213 608.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia 186801|Clostridia T response regulator receiver - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg LANLAPFM_00748 585394.RHOM_09645 0.0 929.0 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,2490X@186801|Clostridia 186801|Clostridia E 'glutamate synthase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 LANLAPFM_00749 585394.RHOM_09650 0.0 2844.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia 186801|Clostridia E 'glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase LANLAPFM_00750 622312.ROSEINA2194_00938 8.66e-155 462.0 COG0550@1|root,COG4465@1|root,COG0550@2|Bacteria,COG4465@2|Bacteria,1TPUS@1239|Firmicutes,248MG@186801|Clostridia 186801|Clostridia L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom LANLAPFM_00751 622312.ROSEINA2194_00938 0.0 1186.0 COG0550@1|root,COG4465@1|root,COG0550@2|Bacteria,COG4465@2|Bacteria,1TPUS@1239|Firmicutes,248MG@186801|Clostridia 186801|Clostridia L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom LANLAPFM_00752 622312.ROSEINA2194_00937 1.23e-142 415.0 COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia 186801|Clostridia LU DNA protecting protein DprA dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A LANLAPFM_00753 585394.RHOM_06900 1.93e-233 657.0 COG0606@1|root,COG0606@2|Bacteria,1TPPB@1239|Firmicutes,248T8@186801|Clostridia 186801|Clostridia O chelatase subunit ChlI comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C LANLAPFM_00754 622312.ROSEINA2194_00935 3.41e-95 282.0 COG1191@1|root,COG1191@2|Bacteria,1TPJ5@1239|Firmicutes,247XH@186801|Clostridia 186801|Clostridia K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released sigK - - ko:K03091 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4 LANLAPFM_00755 622312.ROSEINA2194_00934 1.63e-137 398.0 COG0564@1|root,COG0564@2|Bacteria,1TS1T@1239|Firmicutes,249AH@186801|Clostridia 186801|Clostridia J Responsible for synthesis of pseudouridine from uracil rluD_2 - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 LANLAPFM_00756 585394.RHOM_06885 9.4e-100 294.0 2943S@1|root,2ZRIE@2|Bacteria,1V3J6@1239|Firmicutes,24HEP@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score KatE - - - - - - - - - - - - LANLAPFM_00758 585394.RHOM_06880 3.12e-173 506.0 COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 LANLAPFM_00759 622312.ROSEINA2194_01333 7.74e-85 253.0 COG0622@1|root,COG0622@2|Bacteria,1VA0U@1239|Firmicutes,24MMK@186801|Clostridia 186801|Clostridia S Phosphoesterase yfcE1 - - ko:K07095 - - - - ko00000 - - - Metallophos_2 LANLAPFM_00760 585394.RHOM_02950 3.22e-114 330.0 COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia 186801|Clostridia F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like LANLAPFM_00761 622312.ROSEINA2194_01335 8.69e-166 473.0 COG0860@1|root,COG0860@2|Bacteria,1UYPW@1239|Firmicutes,24BHU@186801|Clostridia 186801|Clostridia M PFAM cell wall hydrolase autolysin - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,Cu_amine_oxidN1 LANLAPFM_00762 622312.ROSEINA2194_01336 2.93e-316 872.0 COG4870@1|root,COG4870@2|Bacteria,1TVCW@1239|Firmicutes,248WA@186801|Clostridia 186801|Clostridia O Papain family cysteine protease - - - - - - - - - - - - Big_2,Cu_amine_oxidN1,Peptidase_C1,Rhodanese LANLAPFM_00763 585394.RHOM_02930 7.36e-258 709.0 COG0116@1|root,COG0116@2|Bacteria,1TP0X@1239|Firmicutes,248MA@186801|Clostridia 186801|Clostridia L Belongs to the methyltransferase superfamily ypsC - - ko:K07444 - - - - ko00000,ko01000 - - - THUMP,UPF0020 LANLAPFM_00764 585394.RHOM_02925 5.04e-37 127.0 COG0607@1|root,COG0607@2|Bacteria,1VGXK@1239|Firmicutes,24R46@186801|Clostridia 186801|Clostridia P Psort location Cytoplasmic, score - - - - - - - - - - - - Rhodanese LANLAPFM_00766 585394.RHOM_02915 0.0 1103.0 COG0664@1|root,COG0664@2|Bacteria,1TSX5@1239|Firmicutes,24A8U@186801|Clostridia 186801|Clostridia T - Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - - - - - - - - - - cNMP_binding LANLAPFM_00767 585394.RHOM_02910 2.52e-219 613.0 COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia 186801|Clostridia H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K01598,ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein LANLAPFM_00768 622312.ROSEINA2194_04364 5.73e-101 296.0 COG0712@1|root,COG0712@2|Bacteria,1VAG3@1239|Firmicutes,24MSA@186801|Clostridia 186801|Clostridia C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP LANLAPFM_00769 585394.RHOM_16045 4.29e-44 150.0 COG0711@1|root,COG0711@2|Bacteria,1V74H@1239|Firmicutes,25CRV@186801|Clostridia 186801|Clostridia C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B LANLAPFM_00770 1235802.C823_01323 1.62e-44 145.0 COG0636@1|root,COG0636@2|Bacteria,1V8SD@1239|Firmicutes,24QMQ@186801|Clostridia,25XKI@186806|Eubacteriaceae 186801|Clostridia C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C LANLAPFM_00771 585394.RHOM_16055 8.22e-154 435.0 COG0356@1|root,COG0356@2|Bacteria,1TQIT@1239|Firmicutes,24A6Q@186801|Clostridia 186801|Clostridia C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A LANLAPFM_00772 622312.ROSEINA2194_04360 1.34e-68 210.0 2CFN0@1|root,32RUQ@2|Bacteria,1VD5D@1239|Firmicutes,24MN1@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - ATP-synt_I LANLAPFM_00773 622312.ROSEINA2194_04359 9.24e-33 115.0 2EC2U@1|root,3361T@2|Bacteria,1VK1M@1239|Firmicutes,24RW0@186801|Clostridia 186801|Clostridia S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - - - - - - - - - - ATPase_gene1 LANLAPFM_00774 585394.RHOM_16075 1.87e-102 297.0 COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24HF0@186801|Clostridia 186801|Clostridia F cytidine and deoxycytidylate deaminase zinc-binding region comEB - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 LANLAPFM_00775 585394.RHOM_16080 1.24e-144 408.0 COG0035@1|root,COG0035@2|Bacteria,1TPMT@1239|Firmicutes,248FV@186801|Clostridia 186801|Clostridia F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate upp - 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000 - - - UPRTase LANLAPFM_00776 622312.ROSEINA2194_04355 5.53e-80 241.0 COG0394@1|root,COG0394@2|Bacteria,1UIG5@1239|Firmicutes,25EMJ@186801|Clostridia 186801|Clostridia T Low molecular weight phosphotyrosine protein phosphatase - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc LANLAPFM_00777 622312.ROSEINA2194_04354 5.17e-209 583.0 COG0009@1|root,COG0009@2|Bacteria,1TP1I@1239|Firmicutes,248HS@186801|Clostridia 186801|Clostridia J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine sua - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - SUA5,Sua5_yciO_yrdC LANLAPFM_00778 585394.RHOM_16095 8.55e-213 592.0 COG2017@1|root,COG2017@2|Bacteria,1TQGJ@1239|Firmicutes,249DZ@186801|Clostridia 186801|Clostridia G Converts alpha-aldose to the beta-anomer - - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim LANLAPFM_00779 585394.RHOM_16100 3.41e-18 76.6 COG2768@1|root,COG2768@2|Bacteria,1VET2@1239|Firmicutes,24QUH@186801|Clostridia 186801|Clostridia C Ferredoxin - - - - - - - - - - - - Fer4 LANLAPFM_00780 622312.ROSEINA2194_00870 9.62e-305 833.0 COG1373@1|root,COG1373@2|Bacteria,1TQ8Z@1239|Firmicutes,2499K@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - AAA_14,DUF4143 LANLAPFM_00781 585394.RHOM_06865 9.22e-46 149.0 2E3QR@1|root,32YNK@2|Bacteria,1VENX@1239|Firmicutes,24QVR@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF1292 LANLAPFM_00782 622312.ROSEINA2194_00929 0.0 891.0 COG0210@1|root,COG0210@2|Bacteria,1TPVG@1239|Firmicutes,2484I@186801|Clostridia 186801|Clostridia L DNA helicase yjcD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C LANLAPFM_00783 585394.RHOM_06855 0.0 922.0 COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia 186801|Clostridia J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17,6.1.1.24 ko:K01885,ko:K09698 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R03651,R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c LANLAPFM_00784 585394.RHOM_06850 2.5e-222 635.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia 186801|Clostridia NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal LANLAPFM_00785 585394.RHOM_06845 3.1e-199 565.0 COG2182@1|root,COG2182@2|Bacteria,1VRPK@1239|Firmicutes,24Y63@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K15770 ko02010,map02010 M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2 - - SBP_bac_8 LANLAPFM_00787 622312.ROSEINA2194_00922 3.08e-33 117.0 2E34J@1|root,32Y4N@2|Bacteria,1VESM@1239|Firmicutes,24QZX@186801|Clostridia 186801|Clostridia S COG NOG18028 non supervised orthologous group cotJB - - ko:K06333 - - - - ko00000 - - - CotJB LANLAPFM_00788 585394.RHOM_06825 6.83e-88 261.0 COG3546@1|root,COG3546@2|Bacteria,1TQVQ@1239|Firmicutes,247YJ@186801|Clostridia 186801|Clostridia P PFAM Manganese containing catalase cotJC - - ko:K06334 - - - - ko00000 - - - Mn_catalase LANLAPFM_00789 457412.RSAG_00803 0.0 897.0 COG1961@1|root,COG1961@2|Bacteria,1TPA6@1239|Firmicutes,247KF@186801|Clostridia,3WGP9@541000|Ruminococcaceae 186801|Clostridia L Resolvase, N terminal domain - - - - - - - - - - - - DUF4368,Recombinase,Resolvase,Zn_ribbon_recom LANLAPFM_00790 483218.BACPEC_01206 6.9e-234 650.0 COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,247XK@186801|Clostridia,2683I@186813|unclassified Clostridiales 186801|Clostridia E Cys/Met metabolism PLP-dependent enzyme - - - - - - - - - - - - Cys_Met_Meta_PP LANLAPFM_00791 483218.BACPEC_01205 1.14e-169 478.0 COG2221@1|root,COG2221@2|Bacteria,1TR7P@1239|Firmicutes,2493K@186801|Clostridia,269QP@186813|unclassified Clostridiales 186801|Clostridia C Nitrite/Sulfite reductase ferredoxin-like half domain - - - ko:K00385 ko00920,ko01120,map00920,map01120 - R00858,R10146 RC00065 ko00000,ko00001 - - - Fer4,Fer4_7,NIR_SIR,NIR_SIR_ferr LANLAPFM_00792 483218.BACPEC_01204 6.62e-46 149.0 COG0425@1|root,COG0425@2|Bacteria,1VBET@1239|Firmicutes,24NV0@186801|Clostridia 186801|Clostridia O Belongs to the sulfur carrier protein TusA family - - - - - - - - - - - - TusA LANLAPFM_00793 483218.BACPEC_01203 1.81e-42 141.0 COG0526@1|root,COG0526@2|Bacteria,1UHN6@1239|Firmicutes,25FT1@186801|Clostridia 186801|Clostridia O Thioredoxin trxA1 - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin LANLAPFM_00794 483218.BACPEC_01202 2.65e-29 105.0 COG2104@1|root,COG2104@2|Bacteria,1VFJR@1239|Firmicutes,24SEU@186801|Clostridia 186801|Clostridia H thiamine biosynthesis protein ThiS thiS - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS LANLAPFM_00795 483218.BACPEC_01201 4.81e-183 510.0 COG0476@1|root,COG0476@2|Bacteria,1TQ3U@1239|Firmicutes,25CJC@186801|Clostridia,269P8@186813|unclassified Clostridiales 186801|Clostridia H ThiF family moeB - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - Rhodanese,ThiF LANLAPFM_00796 1160721.RBI_I01804 2.66e-56 179.0 COG1310@1|root,COG1310@2|Bacteria,1V6TY@1239|Firmicutes,24JI8@186801|Clostridia,3WJ1M@541000|Ruminococcaceae 186801|Clostridia S Mov34 MPN PAD-1 family - - 3.13.1.6 ko:K21140 ko04122,map04122 - R11524 RC00064,RC00090 ko00000,ko00001,ko01000 - - - Prok-JAB LANLAPFM_00797 180332.JTGN01000013_gene974 8.34e-33 146.0 COG2340@1|root,COG3087@1|root,COG3507@1|root,COG3533@1|root,COG2340@2|Bacteria,COG3087@2|Bacteria,COG3507@2|Bacteria,COG3533@2|Bacteria,1TRV9@1239|Firmicutes,24CKP@186801|Clostridia 186801|Clostridia G Beta-L-arabinofuranosidase, GH127 - - - - - - - - - - - - Glyco_hydro_127 LANLAPFM_00799 1280688.AUJB01000008_gene1258 2.69e-35 120.0 COG0227@1|root,COG0227@2|Bacteria,1VEI2@1239|Firmicutes,24QNA@186801|Clostridia,3NHEH@46205|Pseudobutyrivibrio 186801|Clostridia J Ribosomal L28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 LANLAPFM_00800 585394.RHOM_07260 2.12e-72 218.0 COG1302@1|root,COG1302@2|Bacteria,1V731@1239|Firmicutes,24JIA@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - Asp23 LANLAPFM_00801 585394.RHOM_07265 0.0 900.0 COG1461@1|root,COG1461@2|Bacteria,1TQMX@1239|Firmicutes,247XI@186801|Clostridia 186801|Clostridia S DAK2 domain fusion protein YloV - - - ko:K07030 - - - - ko00000 - - - Dak1_2,Dak2 LANLAPFM_00802 585394.RHOM_07270 0.0 999.0 COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia 186801|Clostridia L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge LANLAPFM_00803 585394.RHOM_07275 7.8e-38 127.0 2BX75@1|root,32YCI@2|Bacteria,1VEDY@1239|Firmicutes,24QPW@186801|Clostridia 186801|Clostridia S 'small, acid-soluble spore protein sasP - - ko:K06421 - - - - ko00000 - - - SASP LANLAPFM_00804 585394.RHOM_07295 9.78e-260 713.0 COG4225@1|root,COG4225@2|Bacteria,1TRJ7@1239|Firmicutes,24806@186801|Clostridia 186801|Clostridia S Glycosyl Hydrolase Family 88 - - 3.2.1.172 ko:K15532 - - - - ko00000,ko01000 - GH105 - Glyco_hydro_88 LANLAPFM_00805 665956.HMPREF1032_02998 3.76e-60 199.0 COG1266@1|root,COG1266@2|Bacteria,1USCY@1239|Firmicutes,24F5M@186801|Clostridia,3WMPA@541000|Ruminococcaceae 186801|Clostridia S CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi LANLAPFM_00806 585394.RHOM_07300 0.0 982.0 COG1293@1|root,COG1293@2|Bacteria,1TQ8A@1239|Firmicutes,248RK@186801|Clostridia 186801|Clostridia K Fibronectin-binding protein FbpA - - - - - - - - - - - DUF814,FbpA LANLAPFM_00807 622312.ROSEINA2194_01235 0.0 907.0 COG1236@1|root,COG1236@2|Bacteria,1TQBH@1239|Firmicutes,248QR@186801|Clostridia 186801|Clostridia J exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL LANLAPFM_00808 585394.RHOM_09155 3.96e-159 449.0 COG1191@1|root,COG1191@2|Bacteria,1TPDD@1239|Firmicutes,24A1H@186801|Clostridia 186801|Clostridia K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released sigG - - ko:K03091 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 LANLAPFM_00810 585394.RHOM_09140 6.68e-155 440.0 COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24B81@186801|Clostridia 186801|Clostridia E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF_2 - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase LANLAPFM_00812 585394.RHOM_08785 8.26e-308 863.0 COG0451@1|root,COG0451@2|Bacteria,1UYUX@1239|Firmicutes,24CYP@186801|Clostridia 186801|Clostridia GM Psort location CytoplasmicMembrane, score - - 5.1.3.2 ko:K01784,ko:K21009 ko00052,ko00520,ko01100,ko02025,map00052,map00520,map01100,map02025 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,RmlD_sub_bind LANLAPFM_00813 585394.RHOM_08780 1.37e-123 362.0 28H6W@1|root,2ZA4C@2|Bacteria,1UXGN@1239|Firmicutes,24AZN@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00814 411469.EUBHAL_02519 1.44e-133 419.0 28N1Z@1|root,2ZB7X@2|Bacteria,1UZID@1239|Firmicutes,24F7M@186801|Clostridia,25Y86@186806|Eubacteriaceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00816 585394.RHOM_06705 5.14e-116 336.0 COG1139@1|root,COG1139@2|Bacteria,1TP90@1239|Firmicutes,249B6@186801|Clostridia 186801|Clostridia C PFAM Uncharacterised ACR, YkgG family COG1556 - - - - - - - - - - - - LUD_dom LANLAPFM_00817 622312.ROSEINA2194_03578 0.0 940.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_00818 622312.ROSEINA2194_03581 1.13e-190 538.0 COG0523@1|root,COG0523@2|Bacteria,1TPCG@1239|Firmicutes,248XD@186801|Clostridia 186801|Clostridia K CobW P47K family protein cobW - - - - - - - - - - - CobW_C,cobW LANLAPFM_00819 585394.RHOM_06720 6.96e-196 546.0 COG0523@1|root,COG3689@1|root,COG0523@2|Bacteria,COG3689@2|Bacteria,1TS8P@1239|Firmicutes,248DY@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - cobW LANLAPFM_00820 622312.ROSEINA2194_04232 7.02e-133 384.0 COG2703@1|root,COG2703@2|Bacteria,1VBEC@1239|Firmicutes,24NV2@186801|Clostridia 186801|Clostridia P Hemerythrin HHE cation binding domain - - - ko:K07216 - - - - ko00000 - - - Hemerythrin LANLAPFM_00821 622312.ROSEINA2194_00374 5.58e-160 461.0 COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,248X3@186801|Clostridia 186801|Clostridia S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind LANLAPFM_00822 585394.RHOM_06735 1.78e-179 505.0 COG4120@1|root,COG4120@2|Bacteria,1TPDJ@1239|Firmicutes,249P1@186801|Clostridia 186801|Clostridia S Belongs to the binding-protein-dependent transport system permease family - - - ko:K05832 - M00247 - - ko00000,ko00002,ko02000 - - - BPD_transp_2 LANLAPFM_00823 585394.RHOM_06740 5.41e-162 457.0 COG1101@1|root,COG1101@2|Bacteria,1TPAN@1239|Firmicutes,247WW@186801|Clostridia 186801|Clostridia S Abc transporter - - - ko:K05833 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_tran LANLAPFM_00824 622312.ROSEINA2194_00370 9.43e-202 559.0 COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,247YB@186801|Clostridia 186801|Clostridia C PFAM oxidoreductase FAD NAD(P)-binding domain protein pyrK_1 - 1.18.1.2,1.19.1.1 ko:K00528,ko:K16951 ko00920,ko01120,map00920,map01120 - R00858,R10146,R10159 RC00065 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,NAD_binding_1 LANLAPFM_00825 585394.RHOM_06750 4.16e-313 855.0 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia 186801|Clostridia C 'glutamate synthase gltA - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2 LANLAPFM_00826 622312.ROSEINA2194_00367 0.0 940.0 COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia 186801|Clostridia P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - ko:K12952 - - - - ko00000,ko01000 3.A.3.23 - - E1-E2_ATPase,Hydrolase LANLAPFM_00827 585394.RHOM_06755 1.56e-61 202.0 COG1131@1|root,COG1131@2|Bacteria,1VF25@1239|Firmicutes,248Y7@186801|Clostridia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - LANLAPFM_00828 585394.RHOM_06760 7.49e-130 372.0 COG1131@1|root,COG1131@2|Bacteria,1TPUP@1239|Firmicutes,249FR@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran LANLAPFM_00829 585394.RHOM_06765 2.9e-58 182.0 COG1725@1|root,COG1725@2|Bacteria,1VA2B@1239|Firmicutes,24N57@186801|Clostridia 186801|Clostridia K Transcriptional regulator, GntR family - - - - - - - - - - - - GntR LANLAPFM_00830 397288.C806_04570 2.21e-05 53.5 COG1345@1|root,COG1345@2|Bacteria,1VU42@1239|Firmicutes,24Y6R@186801|Clostridia,27KHZ@186928|unclassified Lachnospiraceae 186801|Clostridia N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end - - - - - - - - - - - - FliD_C LANLAPFM_00832 585394.RHOM_15945 4.9e-123 360.0 28JN4@1|root,2Z9EJ@2|Bacteria,1TRQI@1239|Firmicutes,24E4X@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_00833 585394.RHOM_09375 4.06e-52 170.0 2AKH0@1|root,31B8X@2|Bacteria,1V6ZY@1239|Firmicutes 1239|Firmicutes S Protein of unknown function (DUF2975) - - - - - - - - - - - - DUF2975 LANLAPFM_00834 1235790.C805_03566 9.31e-34 117.0 COG3655@1|root,COG3655@2|Bacteria,1VESP@1239|Firmicutes,24QSQ@186801|Clostridia,25XC8@186806|Eubacteriaceae 186801|Clostridia K DNA-binding helix-turn-helix protein - - - ko:K07727 - - - - ko00000,ko03000 - - - HTH_26 LANLAPFM_00835 585394.RHOM_09365 1.55e-122 375.0 COG0810@1|root,COG0810@2|Bacteria,1UJMR@1239|Firmicutes,251BT@186801|Clostridia 186801|Clostridia M Domain of unknown function (DUF4173) - - - - - - - - - - - - DUF4173 LANLAPFM_00836 585394.RHOM_10170 3.16e-199 562.0 COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248IH@186801|Clostridia 186801|Clostridia S ABC-type transport system, periplasmic component surface lipoprotein - - - ko:K07335 - - - - ko00000 - - - Bmp LANLAPFM_00837 483218.BACPEC_02957 6.97e-141 427.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,26BFA@186813|unclassified Clostridiales 186801|Clostridia NT Single cache domain 3 - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,sCache_3_3 LANLAPFM_00838 622312.ROSEINA2194_01368 7.71e-79 238.0 COG1051@1|root,COG1051@2|Bacteria,1UUZ0@1239|Firmicutes,24NDR@186801|Clostridia 186801|Clostridia F NUDIX domain - - - - - - - - - - - - NUDIX LANLAPFM_00839 585394.RHOM_09310 3.39e-98 286.0 COG1803@1|root,COG1803@2|Bacteria,1V3KQ@1239|Firmicutes,24FUQ@186801|Clostridia 186801|Clostridia G methylglyoxal synthase mgsA - 2.7.1.24,4.2.3.3 ko:K00859,ko:K01734 ko00640,ko00770,ko01100,ko01120,map00640,map00770,map01100,map01120 M00120 R00130,R01016 RC00002,RC00078,RC00424 ko00000,ko00001,ko00002,ko01000 - - - MGS LANLAPFM_00840 585394.RHOM_09305 3.52e-178 499.0 COG1307@1|root,COG1307@2|Bacteria,1TRM7@1239|Firmicutes,248N9@186801|Clostridia 186801|Clostridia S EDD domain protein, DegV family - - - - - - - - - - - - DegV LANLAPFM_00841 585394.RHOM_09300 4.49e-246 684.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia 186801|Clostridia V Mate efflux family protein - - - - - - - - - - - - MatE LANLAPFM_00842 585394.RHOM_09295 2.08e-149 427.0 COG0583@1|root,COG0583@2|Bacteria,1TRJK@1239|Firmicutes,24AY4@186801|Clostridia 186801|Clostridia K lysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate LANLAPFM_00843 1256908.HMPREF0373_01084 5.64e-297 811.0 COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,25V6G@186806|Eubacteriaceae 186801|Clostridia F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt LANLAPFM_00844 585394.RHOM_09285 9.36e-76 233.0 COG1011@1|root,COG1011@2|Bacteria,1V6I4@1239|Firmicutes,24JK7@186801|Clostridia 186801|Clostridia S HAD hydrolase, family IA, variant 3 - - - ko:K07025 - - - - ko00000 - - - HAD_2,Hydrolase LANLAPFM_00845 585394.RHOM_09280 1.73e-144 416.0 COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia 186801|Clostridia V ABC-type multidrug transport system ATPase component - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran LANLAPFM_00846 585394.RHOM_09275 0.0 906.0 COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,1TT1J@1239|Firmicutes,24BC2@186801|Clostridia 186801|Clostridia N -transport system - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3,ABC_transp_aux LANLAPFM_00849 1256908.HMPREF0373_01181 2.76e-244 680.0 COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,24865@186801|Clostridia,25VD8@186806|Eubacteriaceae 186801|Clostridia C citrate synthase - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt LANLAPFM_00850 622312.ROSEINA2194_00357 1.81e-29 106.0 2DR14@1|root,339R7@2|Bacteria,1VMNT@1239|Firmicutes,24UVM@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00851 585394.RHOM_09245 1.72e-112 323.0 COG3012@1|root,COG3012@2|Bacteria,1V1CC@1239|Firmicutes,24FYC@186801|Clostridia 186801|Clostridia U Psort location Cytoplasmic, score secA_2 - - - - - - - - - - - SEC-C LANLAPFM_00852 1121335.Clst_1077 0.0 1123.0 COG2182@1|root,COG2182@2|Bacteria,1UJPM@1239|Firmicutes,25F7T@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_8 LANLAPFM_00853 1449050.JNLE01000003_gene2908 1.28e-157 450.0 COG1175@1|root,COG1175@2|Bacteria,1TR0M@1239|Firmicutes,24CRB@186801|Clostridia 186801|Clostridia G PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 LANLAPFM_00854 1121335.Clst_1079 5.51e-156 444.0 COG0395@1|root,COG0395@2|Bacteria,1TRS1@1239|Firmicutes,24ARW@186801|Clostridia,3WH53@541000|Ruminococcaceae 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 LANLAPFM_00855 1094508.Tsac_1160 1.06e-173 504.0 COG3391@1|root,COG3391@2|Bacteria,1U3IC@1239|Firmicutes,2490J@186801|Clostridia,42I05@68295|Thermoanaerobacterales 186801|Clostridia S PFAM NHL repeat containing protein - - - - - - - - - - - - NHL,Yip1 LANLAPFM_00856 1121335.Clst_1081 1.54e-67 213.0 COG2881@1|root,COG2881@2|Bacteria,1VBWZ@1239|Firmicutes,24MD2@186801|Clostridia 186801|Clostridia S overlaps another CDS with the same product name - - - - - - - - - - - - Yip1 LANLAPFM_00857 1121335.Clst_1082 6.39e-279 801.0 COG3420@1|root,COG3420@2|Bacteria,1TSNZ@1239|Firmicutes,24D4T@186801|Clostridia,3WHC4@541000|Ruminococcaceae 186801|Clostridia P alginic acid biosynthetic process - - - - - - - - - - - - - LANLAPFM_00858 1121335.Clst_1083 7e-118 348.0 COG1175@1|root,COG1175@2|Bacteria,1U73Q@1239|Firmicutes,24AFP@186801|Clostridia,3WHI4@541000|Ruminococcaceae 186801|Clostridia G PFAM binding-protein-dependent transport systems inner membrane component - - - - - - - - - - - - BPD_transp_1 LANLAPFM_00859 1121335.Clst_1084 1.88e-130 381.0 COG0395@1|root,COG0395@2|Bacteria,1UYH5@1239|Firmicutes,24AMA@186801|Clostridia,3WH39@541000|Ruminococcaceae 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 LANLAPFM_00860 1094508.Tsac_1165 1.21e-129 392.0 COG1653@1|root,COG1653@2|Bacteria,1TXES@1239|Firmicutes,25JZ6@186801|Clostridia,42INH@68295|Thermoanaerobacterales 186801|Clostridia G PFAM Bacterial extracellular solute-binding - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - - LANLAPFM_00861 357809.Cphy_3376 1.45e-41 147.0 COG5578@1|root,COG5578@2|Bacteria,1V3XD@1239|Firmicutes,24K78@186801|Clostridia,21YZW@1506553|Lachnoclostridium 186801|Clostridia S Protein of unknown function, DUF624 - - - - - - - - - - - - DUF624 LANLAPFM_00862 1449050.JNLE01000003_gene2847 1.66e-101 309.0 COG1609@1|root,COG1609@2|Bacteria,1TT55@1239|Firmicutes,24A7X@186801|Clostridia,36HMC@31979|Clostridiaceae 186801|Clostridia K PFAM Bacterial regulatory proteins, lacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 LANLAPFM_00863 397291.C804_03195 8.81e-225 622.0 COG2152@1|root,COG2152@2|Bacteria,1TQE7@1239|Firmicutes,249D0@186801|Clostridia,27JZU@186928|unclassified Lachnospiraceae 186801|Clostridia G beta-1,4-mannooligosaccharide phosphorylase - - 2.4.1.319,2.4.1.320 ko:K18785 - - R10811,R10829 RC00049 ko00000,ko01000 - - - Glyco_hydro_130 LANLAPFM_00864 357809.Cphy_2058 1.01e-155 456.0 COG2730@1|root,COG2730@2|Bacteria,1UVAD@1239|Firmicutes,25KF9@186801|Clostridia,223EG@1506553|Lachnoclostridium 186801|Clostridia G Cellulase (glycosyl hydrolase family 5) - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Cellulase LANLAPFM_00865 1123075.AUDP01000048_gene1544 3.75e-55 190.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,249Q3@186801|Clostridia,3WHDK@541000|Ruminococcaceae 186801|Clostridia V MATE efflux family protein - - - - - - - - - - - - MatE LANLAPFM_00866 585394.RHOM_05925 7.03e-244 683.0 COG0714@1|root,COG0714@2|Bacteria,1U8NZ@1239|Firmicutes,248X1@186801|Clostridia 186801|Clostridia S associated with various cellular activities - - - - - - - - - - - - AAA,AAA_5 LANLAPFM_00867 515620.EUBELI_00163 5.69e-279 771.0 COG1488@1|root,COG1488@2|Bacteria,1TPDW@1239|Firmicutes,247NY@186801|Clostridia,25URI@186806|Eubacteriaceae 186801|Clostridia H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP pncB - 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - - NAPRTase,QRPTase_C,QRPTase_N LANLAPFM_00868 658086.HMPREF0994_07307 9.89e-229 643.0 28JJB@1|root,2Z9CE@2|Bacteria,1U6BP@1239|Firmicutes,24B0T@186801|Clostridia,27UAP@186928|unclassified Lachnospiraceae 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_00869 1226325.HMPREF1548_05144 1.96e-86 264.0 2A92C@1|root,30Y6D@2|Bacteria,1V59Y@1239|Firmicutes,25HP5@186801|Clostridia,36I7M@31979|Clostridiaceae 186801|Clostridia S Domain of unknown function (DUF4194) - - - - - - - - - - - - DUF4194 LANLAPFM_00870 1226325.HMPREF1548_05145 0.0 1421.0 COG4913@1|root,COG4913@2|Bacteria,1TPVZ@1239|Firmicutes,2491E@186801|Clostridia,36EUY@31979|Clostridiaceae 186801|Clostridia S DNA replication and repair protein RecF - - - - - - - - - - - - AAA_29,SMC_hinge,SbcCD_C LANLAPFM_00871 556261.HMPREF0240_03393 5.42e-90 285.0 COG4924@1|root,COG4924@2|Bacteria,1V0BQ@1239|Firmicutes,24DRK@186801|Clostridia,36PW8@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function C-terminus (DUF2399) - - - - - - - - - - - - DUF2220,DUF3322 LANLAPFM_00872 585394.RHOM_05930 7.63e-305 843.0 COG3044@1|root,COG3044@2|Bacteria,1TPJ9@1239|Firmicutes,248G5@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - ABC_ATPase LANLAPFM_00873 428125.CLOLEP_01728 0.0 1314.0 COG0178@1|root,COG0178@2|Bacteria,1TP0A@1239|Firmicutes,24B3G@186801|Clostridia,3WN9G@541000|Ruminococcaceae 186801|Clostridia L Psort location Cytoplasmic, score - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran LANLAPFM_00874 515620.EUBELI_00659 3.48e-239 669.0 COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,2481R@186801|Clostridia,25VPU@186806|Eubacteriaceae 186801|Clostridia P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N LANLAPFM_00875 350688.Clos_2061 1.96e-25 112.0 28NDR@1|root,2ZBGG@2|Bacteria,1TSYU@1239|Firmicutes,24E7Y@186801|Clostridia,36PP2@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00876 1232447.BAHW02000039_gene2686 0.0 1114.0 COG0480@1|root,COG3688@1|root,COG0480@2|Bacteria,COG3688@2|Bacteria,1TPQH@1239|Firmicutes,247X4@186801|Clostridia,26843@186813|unclassified Clostridiales 186801|Clostridia J Elongation factor G, domain IV tetP - - - - - - - - - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,NYN_YacP LANLAPFM_00877 585394.RHOM_05940 4.24e-24 93.6 2EHJU@1|root,33BBQ@2|Bacteria,1VN8N@1239|Firmicutes,24VAU@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00879 622312.ROSEINA2194_01363 1.42e-245 674.0 COG0059@1|root,COG0059@2|Bacteria,1TPI7@1239|Firmicutes,247RH@186801|Clostridia 186801|Clostridia H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN LANLAPFM_00880 585394.RHOM_08065 2.56e-104 303.0 COG0440@1|root,COG0440@2|Bacteria,1V2AJ@1239|Firmicutes,24HZM@186801|Clostridia 186801|Clostridia E Acetolactate synthase, small subunit ilvN - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS10025 ACT,ACT_5,ALS_ss_C LANLAPFM_00882 585394.RHOM_08080 3.23e-288 813.0 COG1511@1|root,COG1511@2|Bacteria,1TQ15@1239|Firmicutes,2493H@186801|Clostridia 186801|Clostridia S YhgE Pip pip1 - - ko:K01421 - - - - ko00000 - - - ABC2_membrane,ABC2_membrane_3,DUF3533 LANLAPFM_00883 585394.RHOM_08085 1.44e-46 156.0 COG1511@1|root,COG1511@2|Bacteria,1VFYY@1239|Firmicutes,24RU2@186801|Clostridia 186801|Clostridia S domain protein - - - - - - - - - - - - - LANLAPFM_00884 585394.RHOM_08090 3.7e-273 778.0 COG1511@1|root,COG1511@2|Bacteria,1TQ15@1239|Firmicutes,2493H@186801|Clostridia 186801|Clostridia S YhgE Pip pip1 - - ko:K01421 - - - - ko00000 - - - ABC2_membrane,ABC2_membrane_3,DUF3533 LANLAPFM_00885 1226322.HMPREF1545_00232 1.46e-43 147.0 2DMPJ@1|root,32SWG@2|Bacteria,1V7RA@1239|Firmicutes,24NGU@186801|Clostridia,2N7F0@216572|Oscillospiraceae 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_00886 622312.ROSEINA2194_04170 9.53e-275 763.0 COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,248FH@186801|Clostridia 186801|Clostridia L ImpB MucB SamB family protein - - - ko:K03502 - - - - ko00000,ko03400 - - - IMS,IMS_C,IMS_HHH LANLAPFM_00887 585394.RHOM_07965 3.69e-260 744.0 COG2385@1|root,COG2385@2|Bacteria,1UW6J@1239|Firmicutes,24CYM@186801|Clostridia 186801|Clostridia D SpoIID LytB domain protein - - - ko:K06381 - - - - ko00000 - - - SpoIID LANLAPFM_00888 585394.RHOM_07960 2.63e-149 426.0 COG1295@1|root,COG1295@2|Bacteria,1U7HM@1239|Firmicutes,24A2Q@186801|Clostridia 186801|Clostridia H Belongs to the UPF0761 family yihY - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB LANLAPFM_00889 483218.BACPEC_01341 2.54e-209 582.0 COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,267UI@186813|unclassified Clostridiales 186801|Clostridia J Aminoacyl tRNA synthetase class II, N-terminal domain pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d LANLAPFM_00890 1256908.HMPREF0373_02472 0.0 1295.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,25UVH@186806|Eubacteriaceae 186801|Clostridia J phenylalanyl-tRNA synthetase (beta subunit) pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind LANLAPFM_00891 585394.RHOM_07945 6.84e-230 635.0 COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia 186801|Clostridia J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth LANLAPFM_00892 140626.JHWB01000016_gene2464 9.28e-46 150.0 2E11F@1|root,32WHB@2|Bacteria,1VD34@1239|Firmicutes,24NEB@186801|Clostridia 186801|Clostridia S PilZ domain - - - - - - - - - - - - PilZ LANLAPFM_00894 1280698.AUJS01000065_gene668 3.75e-287 794.0 2CC51@1|root,2Z7IU@2|Bacteria,1TQNI@1239|Firmicutes,24DDD@186801|Clostridia 186801|Clostridia S PFAM conserved - - - - - - - - - - - - DUF2397 LANLAPFM_00895 1280698.AUJS01000065_gene669 6.57e-219 610.0 28HUD@1|root,2Z813@2|Bacteria,1TUFV@1239|Firmicutes,24A4P@186801|Clostridia 186801|Clostridia S PFAM conserved - - - - - - - - - - - - DUF2398 LANLAPFM_00896 1280698.AUJS01000065_gene670 0.0 1654.0 COG1196@1|root,COG1196@2|Bacteria,1TPW9@1239|Firmicutes,247V7@186801|Clostridia 186801|Clostridia D Putative exonuclease SbcCD, C subunit - - - - - - - - - - - - SbcCD_C LANLAPFM_00897 1280698.AUJS01000065_gene671 1.22e-179 514.0 COG4924@1|root,COG4924@2|Bacteria,1TRVG@1239|Firmicutes,24D0P@186801|Clostridia 186801|Clostridia S Protein of unknown function N-terminus (DUF3323) - - - - - - - - - - - - DUF2399,DUF3323 LANLAPFM_00898 622312.ROSEINA2194_02311 0.0 939.0 COG4468@1|root,COG4468@2|Bacteria,1TPBN@1239|Firmicutes,247ZN@186801|Clostridia 186801|Clostridia G UDPglucose--hexose-1-phosphate uridylyltransferase galT - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GalP_UDP_tr_C,GalP_UDP_transf LANLAPFM_00899 622312.ROSEINA2194_02310 6.61e-265 729.0 COG0153@1|root,COG0153@2|Bacteria,1TPD0@1239|Firmicutes,247U8@186801|Clostridia 186801|Clostridia G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) galK - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg LANLAPFM_00900 585394.RHOM_10945 2.71e-251 692.0 COG3867@1|root,COG3867@2|Bacteria,1TQDZ@1239|Firmicutes,24CPM@186801|Clostridia 186801|Clostridia G arabinogalactan - - 3.2.1.89 ko:K01224 - - - - ko00000,ko01000 - - - Glyco_hydro_53 LANLAPFM_00901 622312.ROSEINA2194_04219 0.0 1747.0 COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,248H7@186801|Clostridia 186801|Clostridia G beta-galactosidase lacZ - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N LANLAPFM_00902 622312.ROSEINA2194_04218 1.2e-205 570.0 COG2207@1|root,COG2207@2|Bacteria,1V0IW@1239|Firmicutes,24BME@186801|Clostridia 186801|Clostridia K transcriptional regulator (AraC family) - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18,HTH_AraC LANLAPFM_00903 622312.ROSEINA2194_04217 6.33e-50 157.0 2EAM1@1|root,334PP@2|Bacteria,1VI13@1239|Firmicutes,24ST8@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00904 622312.ROSEINA2194_04216 0.0 1264.0 2DBG1@1|root,2Z91R@2|Bacteria,1TQV4@1239|Firmicutes,24CK0@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00905 622312.ROSEINA2194_04215 1.71e-180 504.0 COG3833@1|root,COG3833@2|Bacteria,1TRB7@1239|Firmicutes,248A7@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K15772 ko02010,map02010 M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2 - - BPD_transp_1 LANLAPFM_00906 622312.ROSEINA2194_04214 0.0 875.0 COG1175@1|root,COG1175@2|Bacteria,1TR2A@1239|Firmicutes,247MA@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K15771 ko02010,map02010 M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2 - - BPD_transp_1 LANLAPFM_00907 622312.ROSEINA2194_04213 1.03e-250 696.0 COG2182@1|root,COG2182@2|Bacteria,1TPU9@1239|Firmicutes,249BY@186801|Clostridia 186801|Clostridia G ABC transporter, solute-binding protein - - - ko:K15770 ko02010,map02010 M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2 - - SBP_bac_8 LANLAPFM_00908 585394.RHOM_10990 1.67e-180 509.0 COG1609@1|root,COG1609@2|Bacteria,1TPZM@1239|Firmicutes,248WQ@186801|Clostridia 186801|Clostridia K Periplasmic binding protein LacI transcriptional regulator - - - - - - - - - - - - LacI,Peripla_BP_1,Peripla_BP_3 LANLAPFM_00909 1163671.JAGI01000002_gene2603 6.97e-246 690.0 COG3507@1|root,COG3507@2|Bacteria,1TP5K@1239|Firmicutes,247R2@186801|Clostridia,36ES1@31979|Clostridiaceae 186801|Clostridia G Belongs to the glycosyl hydrolase 43 family - - 3.2.1.37,3.2.1.55 ko:K01198,ko:K01209 ko00520,ko01100,map00520,map01100 - R01433,R01762 RC00467 ko00000,ko00001,ko01000 - GH43,GH51 - Glyco_hydro_43 LANLAPFM_00910 585394.RHOM_05745 1.25e-251 709.0 COG2755@1|root,COG2755@2|Bacteria,1TPYH@1239|Firmicutes,2486S@186801|Clostridia 186801|Clostridia E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - CBM_4_9,Lipase_GDSL_2 LANLAPFM_00911 1280390.CBQR020000071_gene1456 0.0 908.0 2DB7A@1|root,2Z7KK@2|Bacteria,1TQ2C@1239|Firmicutes,4HFKE@91061|Bacilli,26S01@186822|Paenibacillaceae 91061|Bacilli S Glycosyl hydrolase family 115 - - - - - - - - - - - - Glyco_hydro_115 LANLAPFM_00912 1226325.HMPREF1548_05296 1.45e-200 565.0 COG3405@1|root,COG3405@2|Bacteria,1U1E1@1239|Firmicutes,24878@186801|Clostridia,36FZI@31979|Clostridiaceae 186801|Clostridia G family 8 - - 3.2.1.156 ko:K15531 - - - - ko00000,ko01000 - GH8 - Dockerin_1,Glyco_hydro_8,Polysacc_deac_1 LANLAPFM_00913 397291.C804_04827 9.53e-177 497.0 COG0395@1|root,COG0395@2|Bacteria,1TP14@1239|Firmicutes,2481Z@186801|Clostridia,27KBY@186928|unclassified Lachnospiraceae 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K17320 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 LANLAPFM_00914 397291.C804_04826 3.21e-193 540.0 COG4209@1|root,COG4209@2|Bacteria,1TQ64@1239|Firmicutes,24YP3@186801|Clostridia,27KGJ@186928|unclassified Lachnospiraceae 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K17319 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 LANLAPFM_00915 397291.C804_04825 0.0 982.0 COG1653@1|root,COG1653@2|Bacteria,1TQWF@1239|Firmicutes,24CWD@186801|Clostridia,27IIE@186928|unclassified Lachnospiraceae 186801|Clostridia G PFAM extracellular solute-binding protein family 1 - - - ko:K17318 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - SBP_bac_1,SBP_bac_8 LANLAPFM_00916 585394.RHOM_05765 3.41e-174 509.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UYK2@1239|Firmicutes,247MJ@186801|Clostridia 186801|Clostridia T response regulator receiver - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,Response_reg LANLAPFM_00917 397291.C804_04823 2.35e-155 466.0 COG2972@1|root,COG2972@2|Bacteria,1TPUF@1239|Firmicutes,2491H@186801|Clostridia,27JGZ@186928|unclassified Lachnospiraceae 186801|Clostridia T Histidine kinase - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,His_kinase LANLAPFM_00918 397291.C804_04887 0.0 1081.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,27J28@186928|unclassified Lachnospiraceae 186801|Clostridia G Glycosyl hydrolase family 3 C-terminal domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C LANLAPFM_00919 585394.RHOM_10995 0.0 997.0 COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,2488V@186801|Clostridia 186801|Clostridia G beta-galactosidase - - 3.2.1.23 ko:K12308 ko00052,map00052 - R01105 RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M LANLAPFM_00920 641112.ACOK01000097_gene867 2.94e-78 250.0 COG5464@1|root,COG5464@2|Bacteria,1V3CA@1239|Firmicutes,24H4R@186801|Clostridia,3WK37@541000|Ruminococcaceae 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - Transposase_31 LANLAPFM_00921 397291.C804_02030 2.64e-284 815.0 COG3250@1|root,COG3250@2|Bacteria,1TS96@1239|Firmicutes,248B9@186801|Clostridia,27JAC@186928|unclassified Lachnospiraceae 186801|Clostridia G Glycosyl hydrolases family 2 - - 3.2.1.25 ko:K01192 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N LANLAPFM_00922 585394.RHOM_10595 3.34e-134 386.0 COG0596@1|root,COG0596@2|Bacteria,1TSU3@1239|Firmicutes,24DYW@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_00923 585394.RHOM_10580 6.07e-280 770.0 COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia 186801|Clostridia G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N LANLAPFM_00924 1280664.AUIX01000001_gene784 5.99e-19 87.0 COG0719@1|root,COG0719@2|Bacteria,1TQ21@1239|Firmicutes,249IU@186801|Clostridia,4BY4E@830|Butyrivibrio 186801|Clostridia O Uncharacterized protein family (UPF0051) sufB - - ko:K07033,ko:K09014 - - - - ko00000 - - - UPF0051 LANLAPFM_00925 1235800.C819_01897 7.82e-133 380.0 COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia,27IBR@186928|unclassified Lachnospiraceae 186801|Clostridia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran LANLAPFM_00926 1121115.AXVN01000030_gene3609 0.0 897.0 COG2407@1|root,COG2407@2|Bacteria,1TQDX@1239|Firmicutes,247N8@186801|Clostridia,3XZ0K@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Fucose_iso_C LANLAPFM_00927 658086.HMPREF0994_00224 2.07e-98 291.0 28PTU@1|root,2ZCEZ@2|Bacteria,1U95M@1239|Firmicutes,247W6@186801|Clostridia,27M68@186928|unclassified Lachnospiraceae 186801|Clostridia S Domain of unknown function (DUF4867) - - - - - - - - - - - - DUF4867 LANLAPFM_00928 1226325.HMPREF1548_06302 1.89e-291 803.0 COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,36F3K@31979|Clostridiaceae 186801|Clostridia G Carbohydrate kinase, FGGY xylB - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N LANLAPFM_00929 626523.GCWU000342_02293 1.14e-131 386.0 COG1609@1|root,COG1609@2|Bacteria,1TSRM@1239|Firmicutes,24BFS@186801|Clostridia 186801|Clostridia K Bacterial regulatory proteins, lacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_4 LANLAPFM_00930 397290.C810_04867 5.45e-31 116.0 2B1N9@1|root,31U3S@2|Bacteria,1USHS@1239|Firmicutes,25AHW@186801|Clostridia,27QGU@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00932 585394.RHOM_11330 1.56e-98 287.0 COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,24HD6@186801|Clostridia 186801|Clostridia O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB LANLAPFM_00933 622312.ROSEINA2194_00724 0.0 1216.0 COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,247ZS@186801|Clostridia 186801|Clostridia J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 LANLAPFM_00934 622312.ROSEINA2194_00725 2.58e-32 114.0 COG1314@1|root,COG1314@2|Bacteria,1VG46@1239|Firmicutes 1239|Firmicutes U Preprotein translocase SecG subunit secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG LANLAPFM_00935 585394.RHOM_11345 2.21e-248 690.0 COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia 186801|Clostridia G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N LANLAPFM_00936 457415.HMPREF1006_00874 3.17e-110 350.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,3TB48@508458|Synergistetes 508458|Synergistetes T response regulator receiver - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,Response_reg LANLAPFM_00938 585394.RHOM_11360 1.6e-122 359.0 COG2755@1|root,COG2755@2|Bacteria,1V2MD@1239|Firmicutes,24FWG@186801|Clostridia 186801|Clostridia E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 LANLAPFM_00939 622312.ROSEINA2194_02856 2.24e-228 640.0 COG1696@1|root,COG1696@2|Bacteria,1TP52@1239|Firmicutes,248V4@186801|Clostridia 186801|Clostridia M Membrane protein involved in D-alanine export - - - ko:K19294 - - - - ko00000 - - - MBOAT LANLAPFM_00940 585394.RHOM_11370 1.75e-174 502.0 COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia 186801|Clostridia H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M LANLAPFM_00941 585394.RHOM_11375 2.15e-164 464.0 COG1307@1|root,COG1307@2|Bacteria,1TSKD@1239|Firmicutes,24AE9@186801|Clostridia 186801|Clostridia S EDD domain protein, DegV family - - - - - - - - - - - - DegV LANLAPFM_00942 622312.ROSEINA2194_02860 7.74e-127 379.0 COG5279@1|root,COG5279@2|Bacteria,1TY2Q@1239|Firmicutes,24BDS@186801|Clostridia 186801|Clostridia D protein involved in cytokinesis, contains TGc (transglutaminase protease-like) domain - - - - - - - - - - - - Transglut_core LANLAPFM_00943 622312.ROSEINA2194_02861 1.21e-234 654.0 COG1362@1|root,COG1362@2|Bacteria,1TQ3Z@1239|Firmicutes,248UP@186801|Clostridia 186801|Clostridia E M18 family aminopeptidase - - 3.4.11.21 ko:K01267 - - - - ko00000,ko01000,ko01002,ko04131 - - - Peptidase_M18 LANLAPFM_00944 585394.RHOM_11385 2.43e-76 232.0 2C2B5@1|root,32RA4@2|Bacteria,1V6P1@1239|Firmicutes,24N51@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_00945 622312.ROSEINA2194_02871 4.53e-41 135.0 COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,24QJE@186801|Clostridia 186801|Clostridia K Cold shock protein cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD LANLAPFM_00946 622312.ROSEINA2194_02884 1.12e-95 282.0 COG4720@1|root,COG4720@2|Bacteria,1V1E7@1239|Firmicutes,25CJR@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - ECF-ribofla_trS LANLAPFM_00947 622312.ROSEINA2194_02885 5.63e-204 572.0 COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia 186801|Clostridia E Aminotransferase - - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 LANLAPFM_00948 397287.C807_00219 2.66e-83 254.0 COG2357@1|root,COG2357@2|Bacteria,1TQ2F@1239|Firmicutes,249FE@186801|Clostridia,27U4Q@186928|unclassified Lachnospiraceae 186801|Clostridia T Region found in RelA / SpoT proteins - - 2.7.6.5 ko:K07816 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - RelA_SpoT,Response_reg LANLAPFM_00949 585394.RHOM_11560 5.58e-239 672.0 COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,247UR@186801|Clostridia 186801|Clostridia I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol - - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N LANLAPFM_00950 585394.RHOM_11415 5.13e-116 353.0 COG0840@1|root,COG0840@2|Bacteria,1TQW8@1239|Firmicutes,24EE8@186801|Clostridia 186801|Clostridia NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - - - - - - - - - - MCPsignal LANLAPFM_00951 556261.HMPREF0240_00860 1.62e-151 453.0 COG2199@1|root,COG2199@2|Bacteria,1TQKY@1239|Firmicutes,25EP8@186801|Clostridia,36V2W@31979|Clostridiaceae 186801|Clostridia T Pfam:Cache_1 - - - - - - - - - - - - GGDEF,HAMP,dCache_1 LANLAPFM_00952 622312.ROSEINA2194_02159 7.04e-99 294.0 COG2186@1|root,COG2186@2|Bacteria,1V1Y0@1239|Firmicutes,249UW@186801|Clostridia 186801|Clostridia K FCD domain pdhR - - ko:K05799 - - - - ko00000,ko03000 - - - FCD,GntR LANLAPFM_00953 585394.RHOM_04720 0.0 941.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K06147,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_00954 622312.ROSEINA2194_02642 0.0 892.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia 186801|Clostridia V Abc transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_00955 585394.RHOM_04710 9.72e-157 445.0 COG2035@1|root,COG2035@2|Bacteria,1UYD5@1239|Firmicutes,24B08@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K08974 - - - - ko00000 - - - DUF368 LANLAPFM_00956 585394.RHOM_04700 4.84e-186 533.0 COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia 186801|Clostridia E amino acid carrier protein - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp LANLAPFM_00957 411462.DORLON_00099 1.45e-201 564.0 2C2TA@1|root,2Z7T7@2|Bacteria,1TS53@1239|Firmicutes,248BA@186801|Clostridia,27WMG@189330|Dorea 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - FUSC_2 LANLAPFM_00958 1410632.JHWW01000013_gene237 8.08e-13 68.9 COG0600@1|root,COG0600@2|Bacteria,1TR6A@1239|Firmicutes,247VM@186801|Clostridia,27NJZ@186928|unclassified Lachnospiraceae 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 LANLAPFM_00959 411474.COPEUT_00629 7.07e-23 98.6 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia 186801|Clostridia P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system cysA - 3.6.3.25 ko:K02045,ko:K02052 ko00920,ko02010,ko02024,map00920,map02010,map02024 M00185,M00193 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11,3.A.1.6.1,3.A.1.6.3 - - ABC_tran,TOBE_2 LANLAPFM_00960 1511.CLOST_1547 3.94e-117 343.0 COG0338@1|root,COG0338@2|Bacteria,1UBIY@1239|Firmicutes,24D2Y@186801|Clostridia,25U5G@186804|Peptostreptococcaceae 186801|Clostridia L D12 class N6 adenine-specific DNA methyltransferase - - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 LANLAPFM_00961 1235793.C809_02647 3.36e-150 431.0 COG1032@1|root,COG1032@2|Bacteria,1TRY3@1239|Firmicutes,249Q1@186801|Clostridia,27JZG@186928|unclassified Lachnospiraceae 186801|Clostridia C Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_00964 411468.CLOSCI_00298 1.49e-52 175.0 2CWYZ@1|root,32T0P@2|Bacteria,1VYWB@1239|Firmicutes,24SU1@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00969 397290.C810_01492 2.14e-07 55.5 2B5Z1@1|root,31YV6@2|Bacteria,1UDZ2@1239|Firmicutes,25ITD@186801|Clostridia,27SPM@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00970 1235793.C809_02213 3.63e-81 245.0 2EECP@1|root,30E7Y@2|Bacteria,1V4FS@1239|Firmicutes,24I0P@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_00973 411470.RUMGNA_01910 8.57e-57 186.0 COG0328@1|root,COG3341@1|root,COG0328@2|Bacteria,COG3341@2|Bacteria,1V442@1239|Firmicutes,24HSE@186801|Clostridia,3Y0G9@572511|Blautia 186801|Clostridia L double-stranded RNA RNA-DNA hybrid binding protein rnhA - 3.1.26.4 ko:K03469,ko:K06993 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Cauli_VI,RNase_H LANLAPFM_00974 585394.RHOM_05575 8.72e-298 812.0 COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia 186801|Clostridia E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth LANLAPFM_00975 1235800.C819_03155 2.44e-146 426.0 COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,248AH@186801|Clostridia,27MED@186928|unclassified Lachnospiraceae 186801|Clostridia E Peptidase dimerisation domain - - - ko:K01436,ko:K21613 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 LANLAPFM_00976 1226325.HMPREF1548_00432 3.79e-151 431.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,36E1E@31979|Clostridiaceae 186801|Clostridia EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N LANLAPFM_00977 658086.HMPREF0994_04640 5.81e-189 529.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,27MDB@186928|unclassified Lachnospiraceae 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 LANLAPFM_00978 658086.HMPREF0994_04641 2.27e-150 433.0 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,27JBD@186928|unclassified Lachnospiraceae 186801|Clostridia P Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY LANLAPFM_00979 658086.HMPREF0994_04642 2.97e-165 469.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,27QSG@186928|unclassified Lachnospiraceae 186801|Clostridia EP Oligopeptide/dipeptide transporter, C-terminal region - - - - - - - - - - - - ABC_tran,oligo_HPY LANLAPFM_00980 658086.HMPREF0994_04643 3.16e-298 825.0 COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,25CDM@186801|Clostridia,27RMB@186928|unclassified Lachnospiraceae 186801|Clostridia E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 LANLAPFM_00981 585394.RHOM_08675 5.8e-183 517.0 COG0687@1|root,COG0687@2|Bacteria,1TPY1@1239|Firmicutes,2483K@186801|Clostridia 186801|Clostridia P ABC transporter, solute-binding protein potD - - ko:K11069 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1,SBP_bac_6,SBP_bac_8 LANLAPFM_00982 622312.ROSEINA2194_02731 1.36e-136 392.0 COG1177@1|root,COG1177@2|Bacteria,1V0VD@1239|Firmicutes,25E3C@186801|Clostridia 186801|Clostridia P Abc transporter, permease protein potC - - ko:K11070 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1 LANLAPFM_00983 622312.ROSEINA2194_02730 8.71e-159 449.0 COG1176@1|root,COG1176@2|Bacteria,1TQ7Z@1239|Firmicutes,247Y8@186801|Clostridia 186801|Clostridia P ABC transporter, permease protein potB - - ko:K11071 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1 LANLAPFM_00984 622312.ROSEINA2194_02729 1.37e-231 640.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia 186801|Clostridia P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system potA - 3.6.3.31 ko:K11072 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11.1 - - ABC_tran,TOBE_2 LANLAPFM_00985 622312.ROSEINA2194_02728 8.32e-94 279.0 COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,1V1K5@1239|Firmicutes,24FTC@186801|Clostridia 186801|Clostridia K domain protein puuR - - - - - - - - - - - Cupin_2,HTH_19,HTH_3 LANLAPFM_00987 585394.RHOM_08625 2.55e-123 354.0 COG0572@1|root,COG0572@2|Bacteria,1TQ4V@1239|Firmicutes,24850@186801|Clostridia 186801|Clostridia F Cytidine monophosphokinase udk - 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PRK LANLAPFM_00988 585394.RHOM_08620 8.05e-202 568.0 COG2755@1|root,COG2755@2|Bacteria,1UYZ1@1239|Firmicutes,24BMN@186801|Clostridia 186801|Clostridia E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Dockerin_1,Lipase_GDSL_2 LANLAPFM_00989 1121115.AXVN01000012_gene3091 7.27e-15 68.9 COG2104@1|root,COG2104@2|Bacteria,1VKB4@1239|Firmicutes,25HV0@186801|Clostridia,3Y0TI@572511|Blautia 186801|Clostridia H ThiS family - - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS LANLAPFM_00990 537007.BLAHAN_06473 1.04e-148 422.0 COG2022@1|root,COG2022@2|Bacteria,1TQZ1@1239|Firmicutes,247TJ@186801|Clostridia,3XZG0@572511|Blautia 186801|Clostridia H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG LANLAPFM_00991 585394.RHOM_02670 1.79e-73 228.0 COG1971@1|root,COG1971@2|Bacteria,1V25U@1239|Firmicutes 1239|Firmicutes P Probably functions as a manganese efflux pump ytaF - - - - - - - - - - - Mntp LANLAPFM_00992 658086.HMPREF0994_00444 5.94e-29 108.0 COG2198@1|root,COG2198@2|Bacteria,1VG8R@1239|Firmicutes,24JZF@186801|Clostridia,27PU8@186928|unclassified Lachnospiraceae 186801|Clostridia T Hpt domain - - - - - - - - - - - - Hpt LANLAPFM_00993 622312.ROSEINA2194_01595 4.29e-236 655.0 COG0460@1|root,COG0460@2|Bacteria,1TQ2H@1239|Firmicutes,248MU@186801|Clostridia 186801|Clostridia E homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - Homoserine_dh,NAD_binding_3 LANLAPFM_00994 585394.RHOM_02635 3.05e-83 248.0 COG4492@1|root,COG4492@2|Bacteria,1VAJ9@1239|Firmicutes,24MTS@186801|Clostridia 186801|Clostridia S Belongs to the UPF0735 family pheB - 5.4.99.5 ko:K06209 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R01715 RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_4 LANLAPFM_00995 585394.RHOM_02630 3.29e-42 153.0 COG1512@1|root,COG1512@2|Bacteria,1V8N5@1239|Firmicutes,24H2W@186801|Clostridia 186801|Clostridia S TPM domain - - - ko:K06872 - - - - ko00000 - - - TPM_phosphatase LANLAPFM_00996 622312.ROSEINA2194_01591 8.67e-162 465.0 COG1645@1|root,COG1645@2|Bacteria,1TRYG@1239|Firmicutes,25F3V@186801|Clostridia 186801|Clostridia S bacterial-type flagellum-dependent swarming motility - - - - - - - - - - - - - LANLAPFM_00997 585394.RHOM_02620 2.79e-211 596.0 COG4260@1|root,COG4260@2|Bacteria,1TRYU@1239|Firmicutes,24901@186801|Clostridia 186801|Clostridia L virion core protein (lumpy skin disease virus) - - - - - - - - - - - - Band_7_1 LANLAPFM_00998 1408323.JQKK01000025_gene1380 1.02e-70 224.0 2EN4B@1|root,33FSE@2|Bacteria,1VPF9@1239|Firmicutes,24SXK@186801|Clostridia,27NCJ@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - Tim44,zinc_ribbon_2 LANLAPFM_00999 585394.RHOM_02610 7.05e-227 627.0 COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia 186801|Clostridia J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 LANLAPFM_01000 622312.ROSEINA2194_01586 2.34e-46 155.0 COG5652@1|root,COG5652@2|Bacteria,1VF6Q@1239|Firmicutes,24QQ8@186801|Clostridia 186801|Clostridia S PFAM VanZ family protein - - - - - - - - - - - - VanZ LANLAPFM_01001 622312.ROSEINA2194_01585 3.48e-215 605.0 COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,248HZ@186801|Clostridia 186801|Clostridia M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 LANLAPFM_01002 585394.RHOM_02595 5.47e-134 397.0 COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia 186801|Clostridia D Peptidase, M23 - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 LANLAPFM_01003 622312.ROSEINA2194_01582 1.05e-173 489.0 COG2177@1|root,COG2177@2|Bacteria,1TPND@1239|Firmicutes,24AA6@186801|Clostridia 186801|Clostridia D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation ftsX - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX LANLAPFM_01004 585394.RHOM_02585 5.81e-139 397.0 COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,248HW@186801|Clostridia 186801|Clostridia D cell division ATP-binding protein FtsE ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran LANLAPFM_01005 585394.RHOM_02580 3.34e-246 677.0 COG2508@1|root,COG2508@2|Bacteria,1TTA0@1239|Firmicutes,248HN@186801|Clostridia 186801|Clostridia QT Psort location Cytoplasmic, score cdaR_3 - - ko:K02647 - - - - ko00000,ko03000 - - - HTH_30 LANLAPFM_01006 622312.ROSEINA2194_01579 1.27e-141 407.0 COG1284@1|root,COG1284@2|Bacteria,1TR9J@1239|Firmicutes,25CBM@186801|Clostridia 186801|Clostridia S protein conserved in bacteria (DUF2179) - - - - - - - - - - - - DUF2179,YitT_membrane LANLAPFM_01007 585394.RHOM_02575 8.72e-82 251.0 COG1922@1|root,COG1922@2|Bacteria,1V7RM@1239|Firmicutes,24HC8@186801|Clostridia 186801|Clostridia M Psort location Cytoplasmic, score - - 2.4.1.187 ko:K05946 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01003 - GT26 - Glyco_tran_WecB LANLAPFM_01008 585394.RHOM_14870 0.0 937.0 COG1966@1|root,COG1966@2|Bacteria,1TQN8@1239|Firmicutes,248DZ@186801|Clostridia 186801|Clostridia T carbon starvation protein CstA cstA - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM LANLAPFM_01009 585394.RHOM_02570 2.33e-159 460.0 COG0791@1|root,COG3103@1|root,COG0791@2|Bacteria,COG4991@2|Bacteria,1TRKG@1239|Firmicutes,249Y4@186801|Clostridia 186801|Clostridia MT NlpC p60 family protein - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60,SH3_3 LANLAPFM_01010 592026.GCWU0000282_001066 1.87e-06 47.8 2EI20@1|root,33BTH@2|Bacteria,1VQF2@1239|Firmicutes 1239|Firmicutes S Putative motility protein - - - - - - - - - - - - YjfB_motility LANLAPFM_01011 585394.RHOM_02555 3.88e-75 225.0 COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,24J8Y@186801|Clostridia 186801|Clostridia J endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP LANLAPFM_01012 622312.ROSEINA2194_01572 1.23e-158 449.0 COG2996@1|root,COG2996@2|Bacteria,1TQ1Z@1239|Firmicutes,2498C@186801|Clostridia 186801|Clostridia S S1, RNA binding domain cvfB - - ko:K00243 - - - - ko00000 - - - S1,S1_2 LANLAPFM_01013 622312.ROSEINA2194_01571 5.63e-102 303.0 COG3884@1|root,COG3884@2|Bacteria,1TRH5@1239|Firmicutes,24G5K@186801|Clostridia 186801|Clostridia I Acyl-ACP thioesterase - - 3.1.2.21 ko:K01071 ko00061,ko01100,map00061,map01100 - R04014,R08157,R08158 RC00014,RC00039 ko00000,ko00001,ko01000,ko01004 - - - Acyl-ACP_TE LANLAPFM_01015 585394.RHOM_02540 4.79e-124 356.0 COG1739@1|root,COG1739@2|Bacteria,1V6MQ@1239|Firmicutes,248W7@186801|Clostridia 186801|Clostridia S YigZ family yvyE - - - - - - - - - - - DUF1949,UPF0029 LANLAPFM_01016 585394.RHOM_02535 0.0 1373.0 COG5009@1|root,COG5009@2|Bacteria,1UI0H@1239|Firmicutes,25E95@186801|Clostridia 186801|Clostridia M penicillin-binding protein - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase LANLAPFM_01018 397287.C807_03073 1.23e-12 62.4 2EIY3@1|root,33CP9@2|Bacteria,1VN11@1239|Firmicutes,24W71@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01019 411483.FAEPRAA2165_02657 8.46e-49 162.0 COG3597@1|root,COG3597@2|Bacteria,1TSZW@1239|Firmicutes,249YT@186801|Clostridia,3WKSA@541000|Ruminococcaceae 186801|Clostridia S Domain of unknown function (DUF697) - - - - - - - - - - - - DUF697,MMR_HSR1 LANLAPFM_01020 556261.HMPREF0240_04096 1.23e-16 75.1 COG5566@1|root,COG5566@2|Bacteria,1VK7Y@1239|Firmicutes,24SS6@186801|Clostridia,36MMH@31979|Clostridiaceae 186801|Clostridia S Mor transcription activator family - - - - - - - - - - - - Mor LANLAPFM_01023 1095750.HMPREF9970_1659 2.56e-284 852.0 COG0515@1|root,COG3903@1|root,COG0515@2|Bacteria,COG3903@2|Bacteria,1TY16@1239|Firmicutes,24A3H@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - NB-ARC,Pkinase LANLAPFM_01024 1095750.HMPREF9970_1658 1.2e-99 311.0 COG5044@1|root,COG5044@2|Bacteria,1VXKX@1239|Firmicutes,252J9@186801|Clostridia 186801|Clostridia O Rab GDP-dissociation inhibitor activity - - - - - - - - - - - - - LANLAPFM_01025 1408323.JQKK01000008_gene2069 2.05e-55 176.0 COG1895@1|root,COG1895@2|Bacteria,1VG5F@1239|Firmicutes,24RT7@186801|Clostridia,27PUE@186928|unclassified Lachnospiraceae 186801|Clostridia S HEPN domain - - - - - - - - - - - - HEPN LANLAPFM_01026 877421.AUJT01000008_gene2695 1.51e-49 160.0 COG1669@1|root,COG1669@2|Bacteria,1VBZU@1239|Firmicutes,24VNT@186801|Clostridia,27PBK@186928|unclassified Lachnospiraceae 186801|Clostridia S Nucleotidyltransferase domain - - - - - - - - - - - - NTP_transf_2 LANLAPFM_01027 742765.HMPREF9457_03704 3.54e-24 94.7 COG1708@1|root,COG1708@2|Bacteria,1UKQY@1239|Firmicutes,25G1K@186801|Clostridia 186801|Clostridia S Nucleotidyltransferase domain - - - - - - - - - - - - NTP_transf_2 LANLAPFM_01028 592026.GCWU0000282_002501 5.86e-89 270.0 COG1475@1|root,COG1475@2|Bacteria,1TR7C@1239|Firmicutes,247TW@186801|Clostridia 186801|Clostridia K Belongs to the ParB family - - - - - - - - - - - - ParBc LANLAPFM_01029 1329250.WOSG25_090490 0.0 914.0 COG3507@1|root,COG3507@2|Bacteria,1TP5K@1239|Firmicutes,4HA16@91061|Bacilli,4AXIH@81850|Leuconostocaceae 91061|Bacilli G Glycosyl hydrolases family 43 xynB - 3.2.1.37 ko:K01198 ko00520,ko01100,map00520,map01100 - R01433 RC00467 ko00000,ko00001,ko01000 - GH43 - DUF1349,Glyco_hydro_43 LANLAPFM_01030 411469.EUBHAL_01641 2.02e-23 96.3 COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,248FK@186801|Clostridia,25VWT@186806|Eubacteriaceae 186801|Clostridia S Oxidoreductase, aldo keto reductase family protein - - - - - - - - - - - - Aldo_ket_red,MerR_1 LANLAPFM_01031 658086.HMPREF0994_03790 2.21e-127 379.0 COG1680@1|root,COG1680@2|Bacteria,1UC2C@1239|Firmicutes,24B3Q@186801|Clostridia,27QDK@186928|unclassified Lachnospiraceae 186801|Clostridia V Beta-lactamase - - - - - - - - - - - - Beta-lactamase LANLAPFM_01032 1449050.JNLE01000003_gene1418 7.58e-174 497.0 COG1680@1|root,COG1680@2|Bacteria,1UC2C@1239|Firmicutes,24B3Q@186801|Clostridia,36FP4@31979|Clostridiaceae 186801|Clostridia V beta-lactamase - - - - - - - - - - - - Beta-lactamase LANLAPFM_01033 1304880.JAGB01000002_gene1700 4.86e-170 495.0 COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia 186801|Clostridia V Mate efflux family protein - - - - - - - - - - - - MatE LANLAPFM_01034 1235798.C817_00754 1.67e-100 299.0 COG5551@1|root,COG5551@2|Bacteria,1V7VJ@1239|Firmicutes,24IY3@186801|Clostridia 186801|Clostridia S CRISPR-associated endoribonuclease Cas6 cas6 - - - - - - - - - - - CRISPR_Cas6 LANLAPFM_01035 1235798.C817_00755 0.0 926.0 COG1353@1|root,COG1353@2|Bacteria,1TRW5@1239|Firmicutes,24BI3@186801|Clostridia 186801|Clostridia S CRISPR-associated protein, Csm1 family csm1 - - ko:K07016 - - - - ko00000,ko02048 - - - HD LANLAPFM_01036 1235798.C817_00756 4.57e-47 155.0 COG1421@1|root,COG1421@2|Bacteria,1VGBY@1239|Firmicutes,24R4K@186801|Clostridia 186801|Clostridia L CRISPR-associated protein, Csm2 family csm2 - - ko:K19138 - - - - ko00000,ko02048 - - - Csm2_III-A LANLAPFM_01037 1235798.C817_00757 1.13e-97 290.0 COG1337@1|root,COG1337@2|Bacteria,1V3DM@1239|Firmicutes,24IQD@186801|Clostridia 186801|Clostridia L CRISPR-associated RAMP protein, Csm3 family csm3 - - ko:K09002 - - - - ko00000,ko02048 - - - RAMPs LANLAPFM_01038 1235798.C817_00758 2.54e-119 352.0 COG1567@1|root,COG1567@2|Bacteria,1V4UZ@1239|Firmicutes,24IT6@186801|Clostridia 186801|Clostridia L CRISPR-associated RAMP protein, Csm4 family csm4 - - ko:K19139 - - - - ko00000,ko02048 - - - RAMPs LANLAPFM_01039 1235798.C817_00759 1.61e-142 416.0 COG1332@1|root,COG1332@2|Bacteria,1V8JA@1239|Firmicutes,24IAY@186801|Clostridia 186801|Clostridia L CRISPR-associated RAMP protein, Csm5 family csm5 - - ko:K19140 - - - - ko00000,ko02048 - - - RAMPs LANLAPFM_01042 585394.RHOM_07895 4.71e-51 163.0 2EJ0U@1|root,33CS0@2|Bacteria,1VKD6@1239|Firmicutes,24W6Q@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01043 622312.ROSEINA2194_03829 2.17e-35 122.0 2BC9Q@1|root,325UU@2|Bacteria,1URUY@1239|Firmicutes,24WWT@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01044 585394.RHOM_07905 1.44e-213 601.0 COG3391@1|root,COG5492@1|root,COG3391@2|Bacteria,COG5492@2|Bacteria,1TR9I@1239|Firmicutes,24CXQ@186801|Clostridia 186801|Clostridia M cell wall binding repeat - - - - - - - - - - - - Flg_new LANLAPFM_01045 585394.RHOM_07910 0.0 1262.0 COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,247N4@186801|Clostridia 186801|Clostridia J elongation factor g fusA2 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 LANLAPFM_01046 585394.RHOM_07915 2.2e-188 531.0 COG0287@1|root,COG0287@2|Bacteria,1TPXG@1239|Firmicutes,248KX@186801|Clostridia 186801|Clostridia E prephenate dehydrogenase tyrA - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - ACT,PDH LANLAPFM_01048 1408312.JNJS01000006_gene701 1.42e-33 129.0 COG5434@1|root,COG5434@2|Bacteria,1TSA5@1239|Firmicutes,24B0W@186801|Clostridia,3NHBQ@46205|Pseudobutyrivibrio 186801|Clostridia M Parallel beta-helix repeats - - - - - - - - - - - - - LANLAPFM_01049 585394.RHOM_12785 1.2e-187 545.0 COG0840@1|root,COG3290@1|root,COG0840@2|Bacteria,COG3290@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia 186801|Clostridia NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,dCache_1 LANLAPFM_01050 585394.RHOM_12780 0.0 1127.0 COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia 186801|Clostridia P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase LANLAPFM_01051 585394.RHOM_01265 5.07e-165 467.0 2E1XD@1|root,32X6E@2|Bacteria,1VC0W@1239|Firmicutes,24P6H@186801|Clostridia 186801|Clostridia S SseB protein N-terminal domain - - - - - - - - - - - - SseB LANLAPFM_01052 585394.RHOM_01325 9.67e-97 283.0 COG2606@1|root,COG2606@2|Bacteria,1V6JF@1239|Firmicutes,24I4E@186801|Clostridia 186801|Clostridia S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily ybaK - - ko:K03976 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit LANLAPFM_01053 585394.RHOM_01330 3.17e-85 256.0 COG3247@1|root,COG3247@2|Bacteria,1VBAR@1239|Firmicutes,25CUJ@186801|Clostridia 186801|Clostridia S Short repeat of unknown function (DUF308) - - - - - - - - - - - - DUF308 LANLAPFM_01054 622312.ROSEINA2194_02398 7.27e-231 653.0 COG2199@1|root,COG2206@1|root,COG2199@2|Bacteria,COG2206@2|Bacteria,1V6WM@1239|Firmicutes,24FPG@186801|Clostridia 186801|Clostridia T metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - GAF_2,GAF_3,GGDEF,HD,HD_5,HisKA_7TM LANLAPFM_01055 622312.ROSEINA2194_02399 4.22e-41 135.0 2E7JQ@1|root,3321V@2|Bacteria,1VH9B@1239|Firmicutes,24S7B@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - LANLAPFM_01056 622312.ROSEINA2194_02400 1.27e-164 470.0 COG2206@1|root,COG2206@2|Bacteria,1TQIM@1239|Firmicutes,248S5@186801|Clostridia 186801|Clostridia T PFAM metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - HD,HD_5 LANLAPFM_01057 585394.RHOM_01380 3.79e-106 309.0 COG1309@1|root,COG1309@2|Bacteria,1V44I@1239|Firmicutes,24I73@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - TetR_N LANLAPFM_01058 1235802.C823_05083 0.0 1008.0 COG1033@1|root,COG1033@2|Bacteria,1VSWA@1239|Firmicutes,247R6@186801|Clostridia,25UQF@186806|Eubacteriaceae 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K07003 - - - - ko00000 - - - MMPL LANLAPFM_01059 585394.RHOM_01390 1.11e-127 412.0 COG1511@1|root,COG1511@2|Bacteria,1TQ15@1239|Firmicutes,24A8K@186801|Clostridia 186801|Clostridia J Psort location Cellwall, score - - - ko:K01421 - - - - ko00000 - - - - LANLAPFM_01060 585394.RHOM_01395 1.58e-86 259.0 COG1971@1|root,COG1971@2|Bacteria,1V9RZ@1239|Firmicutes,24KSZ@186801|Clostridia 186801|Clostridia P Probably functions as a manganese efflux pump - - - - - - - - - - - - Mntp LANLAPFM_01061 622312.ROSEINA2194_02404 1.59e-289 811.0 COG1032@1|root,COG1032@2|Bacteria,1TPGT@1239|Firmicutes,247JS@186801|Clostridia 186801|Clostridia C Radical SAM domain protein - - 1.21.98.3 ko:K04034 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R06268,R06269,R06270 RC00741,RC01491,RC01492 ko00000,ko00001,ko01000 - - - B12-binding,DUF4080,Radical_SAM LANLAPFM_01062 622312.ROSEINA2194_02405 4.63e-94 282.0 COG2176@1|root,COG2176@2|Bacteria,1V3E4@1239|Firmicutes,249X5@186801|Clostridia 186801|Clostridia L 'dna polymerase iii - - 2.7.7.7 ko:K03763 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T LANLAPFM_01063 585394.RHOM_01415 2.89e-59 191.0 2C456@1|root,32S3D@2|Bacteria,1VBI4@1239|Firmicutes,24N4Y@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01065 585394.RHOM_01425 8.19e-237 667.0 COG2720@1|root,COG2720@2|Bacteria,1TSH8@1239|Firmicutes,2493X@186801|Clostridia 186801|Clostridia V PFAM VanW family protein - - - ko:K18346 ko01502,ko02020,map01502,map02020 M00651 - - ko00000,ko00001,ko00002,ko01504 - - - G5,PG_binding_4,VanW LANLAPFM_01066 585394.RHOM_01430 6.98e-203 565.0 COG0309@1|root,COG0309@2|Bacteria,1TQP4@1239|Firmicutes,24963@186801|Clostridia 186801|Clostridia O PFAM AIR synthase related protein hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C LANLAPFM_01067 622312.ROSEINA2194_02409 7.69e-105 303.0 COG1522@1|root,COG1522@2|Bacteria,1V3PB@1239|Firmicutes,24I3N@186801|Clostridia 186801|Clostridia K transcriptional regulator, AsnC family Lrp - - - - - - - - - - - AsnC_trans_reg,HTH_24 LANLAPFM_01068 585394.RHOM_01440 4.23e-266 730.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia 186801|Clostridia E PFAM aminotransferase class I and II aspC - - ko:K10907 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 LANLAPFM_01069 585394.RHOM_01445 2.06e-121 346.0 COG0219@1|root,COG0219@2|Bacteria,1V3GW@1239|Firmicutes,24HVV@186801|Clostridia 186801|Clostridia J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase LANLAPFM_01070 585394.RHOM_01450 3.84e-180 504.0 COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia 186801|Clostridia P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates ecfA2 - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran LANLAPFM_01071 585394.RHOM_01455 1.04e-191 534.0 COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia 186801|Clostridia P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates ecfA2 - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran LANLAPFM_01072 622312.ROSEINA2194_02414 3.49e-163 460.0 COG0619@1|root,COG0619@2|Bacteria,1TQ0E@1239|Firmicutes,248AB@186801|Clostridia 186801|Clostridia P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates ecfT - - ko:K16785 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - CbiQ LANLAPFM_01073 585394.RHOM_01465 8.64e-151 427.0 COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248W2@186801|Clostridia 186801|Clostridia J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 LANLAPFM_01074 1415775.U729_2947 1.89e-36 129.0 2E529@1|root,32ZVG@2|Bacteria,1VGFJ@1239|Firmicutes,24R64@186801|Clostridia,36NH8@31979|Clostridiaceae 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_3,HTH_31 LANLAPFM_01075 1235798.C817_02114 4.28e-102 313.0 COG0515@1|root,COG0515@2|Bacteria,1V7U3@1239|Firmicutes,25AZB@186801|Clostridia 186801|Clostridia KLT Serine threonine protein kinase - - - - - - - - - - - - Pkinase LANLAPFM_01076 1235798.C817_02113 2.02e-17 74.3 2EJDK@1|root,33D4M@2|Bacteria,1VPVH@1239|Firmicutes,24VVZ@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - RHH_5 LANLAPFM_01077 476272.RUMHYD_01730 1.5e-57 188.0 2DPEI@1|root,331RX@2|Bacteria,1VIYX@1239|Firmicutes,24REE@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF5067) - - - - - - - - - - - - DUF4352 LANLAPFM_01078 585394.RHOM_01470 1.68e-98 286.0 COG0102@1|root,COG0102@2|Bacteria,1V3HX@1239|Firmicutes,24HD9@186801|Clostridia 186801|Clostridia J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 LANLAPFM_01079 585394.RHOM_01475 3.52e-83 246.0 COG0103@1|root,COG0103@2|Bacteria,1V3MQ@1239|Firmicutes,24H94@186801|Clostridia 186801|Clostridia J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 LANLAPFM_01080 428127.EUBDOL_01389 9.38e-190 527.0 COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,3VPAB@526524|Erysipelotrichia 526524|Erysipelotrichia D CobQ CobB MinD ParA nucleotide binding domain protein - - - - - - - - - - - - AAA_31 LANLAPFM_01081 411470.RUMGNA_00788 2.53e-213 590.0 COG1475@1|root,COG1475@2|Bacteria,1TR7C@1239|Firmicutes,247TW@186801|Clostridia,3XYXW@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc LANLAPFM_01082 585394.RHOM_02760 1.48e-91 287.0 COG3773@1|root,COG3883@1|root,COG3773@2|Bacteria,COG3883@2|Bacteria,1V02Q@1239|Firmicutes,24CZW@186801|Clostridia 186801|Clostridia M Cell wall hydrolase - - - - - - - - - - - - Hydrolase_2 LANLAPFM_01083 585394.RHOM_02755 5.49e-209 590.0 COG2206@1|root,COG2206@2|Bacteria,1UUCI@1239|Firmicutes,24CPS@186801|Clostridia 186801|Clostridia T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD LANLAPFM_01084 585394.RHOM_02740 0.0 2013.0 COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,2498I@186801|Clostridia 186801|Clostridia F Carbamoyl-phosphate synthetase ammonia chain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,DAP_epimerase,MGS LANLAPFM_01085 622312.ROSEINA2194_01607 1.28e-241 665.0 COG0505@1|root,COG0505@2|Bacteria,1TQ8N@1239|Firmicutes,247Q8@186801|Clostridia 186801|Clostridia F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase LANLAPFM_01086 585394.RHOM_07470 1.21e-159 463.0 COG1530@1|root,COG1530@2|Bacteria,1TQS4@1239|Firmicutes,247QV@186801|Clostridia 186801|Clostridia J ribonuclease, Rne Rng family rng - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1,TRAM LANLAPFM_01087 585394.RHOM_07465 9.4e-123 355.0 COG5011@1|root,COG5011@2|Bacteria,1V4D0@1239|Firmicutes,249GU@186801|Clostridia 186801|Clostridia S Radical SAM-linked protein - - - - - - - - - - - - DUF2344 LANLAPFM_01088 585394.RHOM_07460 0.0 1066.0 COG1032@1|root,COG1032@2|Bacteria,1TR2C@1239|Firmicutes,248HM@186801|Clostridia 186801|Clostridia C radical SAM domain protein - - - - - - - - - - - - Radical_SAM LANLAPFM_01090 585394.RHOM_07450 3.36e-124 369.0 COG3274@1|root,COG3274@2|Bacteria,1VSWJ@1239|Firmicutes,248AQ@186801|Clostridia 186801|Clostridia S Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 LANLAPFM_01091 397290.C810_00822 3.82e-138 405.0 COG2865@1|root,COG2865@2|Bacteria,1US7F@1239|Firmicutes,24E9U@186801|Clostridia,27MAH@186928|unclassified Lachnospiraceae 186801|Clostridia K Putative ATP-dependent DNA helicase recG C-terminal - - - - - - - - - - - - AlbA_2,HATPase_c_4,HTH_24 LANLAPFM_01092 397290.C810_00822 1.82e-118 352.0 COG2865@1|root,COG2865@2|Bacteria,1US7F@1239|Firmicutes,24E9U@186801|Clostridia,27MAH@186928|unclassified Lachnospiraceae 186801|Clostridia K Putative ATP-dependent DNA helicase recG C-terminal - - - - - - - - - - - - AlbA_2,HATPase_c_4,HTH_24 LANLAPFM_01093 585394.RHOM_07445 1.45e-268 739.0 COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1UYNA@1239|Firmicutes,247RS@186801|Clostridia 186801|Clostridia E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS05760 His_biosynth,PRA-CH,PRA-PH LANLAPFM_01094 585394.RHOM_07440 1.57e-122 351.0 COG0131@1|root,COG0131@2|Bacteria,1TRH7@1239|Firmicutes,247WC@186801|Clostridia 186801|Clostridia E imidazoleglycerol-phosphate dehydratase hisB - 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD LANLAPFM_01095 622312.ROSEINA2194_03708 5.04e-257 711.0 COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,248X8@186801|Clostridia 186801|Clostridia E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh LANLAPFM_01096 585394.RHOM_07430 4.38e-142 402.0 COG0040@1|root,COG0040@2|Bacteria,1TSVZ@1239|Firmicutes,249AR@186801|Clostridia 186801|Clostridia E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765,ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG LANLAPFM_01097 622312.ROSEINA2194_03704 4.46e-203 571.0 COG3705@1|root,COG3705@2|Bacteria,1TPZZ@1239|Firmicutes,248CB@186801|Clostridia 186801|Clostridia E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His LANLAPFM_01098 585394.RHOM_07420 4.26e-109 315.0 COG3331@1|root,COG3331@2|Bacteria,1V3S4@1239|Firmicutes,24G7S@186801|Clostridia 186801|Clostridia L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation recU - - ko:K03700 - - - - ko00000,ko03400 - - - RecU LANLAPFM_01099 585394.RHOM_07410 7.35e-149 428.0 COG0564@1|root,COG0564@2|Bacteria,1TR1M@1239|Firmicutes,248W3@186801|Clostridia 186801|Clostridia J Responsible for synthesis of pseudouridine from uracil rluC - 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 LANLAPFM_01100 622312.ROSEINA2194_03698 0.0 1143.0 COG1032@1|root,COG1032@2|Bacteria,1TQ8X@1239|Firmicutes,248IW@186801|Clostridia 186801|Clostridia C UPF0313 protein - - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N LANLAPFM_01101 622312.ROSEINA2194_03697 9.12e-120 348.0 COG1187@1|root,COG1187@2|Bacteria,1TQZ2@1239|Firmicutes,248HC@186801|Clostridia 186801|Clostridia J Belongs to the pseudouridine synthase RsuA family rsuA - 5.4.99.19 ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 LANLAPFM_01102 585394.RHOM_07395 1.52e-107 320.0 COG0739@1|root,COG0739@2|Bacteria,1TQMQ@1239|Firmicutes,24B3J@186801|Clostridia 186801|Clostridia M COG0739 Membrane proteins related to metalloendopeptidases - - - ko:K21472 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 LANLAPFM_01103 585394.RHOM_07390 1.46e-261 727.0 COG2195@1|root,COG2195@2|Bacteria,1TQBS@1239|Firmicutes,24860@186801|Clostridia 186801|Clostridia E Dipeptidase pepD - - ko:K01270 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 LANLAPFM_01104 585394.RHOM_07385 3.85e-102 309.0 COG3314@1|root,COG3314@2|Bacteria,1TR0V@1239|Firmicutes,247XA@186801|Clostridia 186801|Clostridia S Sporulation integral membrane protein YlbJ ylbJ - - - - - - - - - - - Gate LANLAPFM_01105 585394.RHOM_07380 7.65e-62 198.0 COG0711@1|root,COG0711@2|Bacteria,1V97P@1239|Firmicutes,24JGQ@186801|Clostridia 186801|Clostridia C Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_01106 585394.RHOM_07375 8.89e-101 293.0 COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,24HC3@186801|Clostridia 186801|Clostridia H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like LANLAPFM_01107 585394.RHOM_07370 6.22e-96 283.0 COG0742@1|root,COG0742@2|Bacteria,1V3JF@1239|Firmicutes,24JHR@186801|Clostridia 186801|Clostridia L RNA methyltransferase, RsmD family rsmD - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 LANLAPFM_01108 585394.RHOM_07365 3.92e-73 224.0 COG1546@1|root,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,249WC@186801|Clostridia 186801|Clostridia S Belongs to the CinA family cinA - 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth LANLAPFM_01109 585394.RHOM_07360 6.44e-32 116.0 COG0558@1|root,COG0558@2|Bacteria,1V6PJ@1239|Firmicutes,24J7Y@186801|Clostridia 186801|Clostridia I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf LANLAPFM_01110 585394.RHOM_07360 6.27e-59 186.0 COG0558@1|root,COG0558@2|Bacteria,1V6PJ@1239|Firmicutes,24J7Y@186801|Clostridia 186801|Clostridia I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf LANLAPFM_01111 622312.ROSEINA2194_03690 2.37e-289 793.0 COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia 186801|Clostridia J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 LANLAPFM_01112 622312.ROSEINA2194_03689 1.83e-44 146.0 COG1758@1|root,COG1758@2|Bacteria,1VF65@1239|Firmicutes 1239|Firmicutes K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 LANLAPFM_01113 622312.ROSEINA2194_03688 7.3e-118 340.0 COG0194@1|root,COG0194@2|Bacteria,1TP0M@1239|Firmicutes,24HEX@186801|Clostridia 186801|Clostridia F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin LANLAPFM_01114 622312.ROSEINA2194_03687 1.19e-46 150.0 COG2052@1|root,COG2052@2|Bacteria,1VA40@1239|Firmicutes,24MXV@186801|Clostridia 186801|Clostridia S Belongs to the UPF0296 family NPD7_560 - - ko:K09777 - - - - ko00000 - - - DUF370 LANLAPFM_01115 622312.ROSEINA2194_03686 7.89e-164 463.0 COG1561@1|root,COG1561@2|Bacteria,1TQHJ@1239|Firmicutes,24824@186801|Clostridia 186801|Clostridia S TIGR00255 family yicC - - - - - - - - - - - DUF1732,YicC_N LANLAPFM_01116 585394.RHOM_07330 4.73e-96 283.0 COG1827@1|root,COG1827@2|Bacteria,1V6EY@1239|Firmicutes,24JF2@186801|Clostridia 186801|Clostridia K 3H domain niaR - - ko:K07105 - - - - ko00000 - - - 3H,HTH_11 LANLAPFM_01117 585394.RHOM_07325 3.9e-168 474.0 COG0157@1|root,COG0157@2|Bacteria,1TPQC@1239|Firmicutes,248P2@186801|Clostridia 186801|Clostridia H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS12010 QRPTase_C,QRPTase_N LANLAPFM_01118 585394.RHOM_07320 1.22e-256 707.0 COG0029@1|root,COG0029@2|Bacteria,1UHSP@1239|Firmicutes,25E6F@186801|Clostridia 186801|Clostridia H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C LANLAPFM_01119 471875.RUMLAC_00642 4.08e-145 417.0 COG0379@1|root,COG0379@2|Bacteria,1TP6R@1239|Firmicutes,247IJ@186801|Clostridia,3WGEP@541000|Ruminococcaceae 186801|Clostridia H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS12020 NadA LANLAPFM_01120 622312.ROSEINA2194_03684 1.58e-56 180.0 2BVD7@1|root,32QT8@2|Bacteria,1V6S8@1239|Firmicutes,24HAM@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_01121 1042156.CXIVA_21730 9e-12 62.8 COG1925@1|root,COG1925@2|Bacteria,1VAQP@1239|Firmicutes,24N19@186801|Clostridia,36M8R@31979|Clostridiaceae 186801|Clostridia G phosphocarrier protein HPr - - - - - - - - - - - - PTS-HPr LANLAPFM_01122 585394.RHOM_07305 0.0 932.0 COG1164@1|root,COG1164@2|Bacteria,1TP4P@1239|Firmicutes,248TP@186801|Clostridia 186801|Clostridia E Oligoendopeptidase f pepF - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N LANLAPFM_01123 585394.RHOM_05265 3.39e-85 289.0 2C4YK@1|root,342PE@2|Bacteria,1VWY9@1239|Firmicutes,24TZZ@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01124 622312.ROSEINA2194_01457 4.45e-86 257.0 COG0703@1|root,COG0703@2|Bacteria,1V3W6@1239|Firmicutes,24HKA@186801|Clostridia 186801|Clostridia E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI LANLAPFM_01125 585394.RHOM_02240 6.48e-208 593.0 COG0739@1|root,COG1388@1|root,COG3583@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,COG3583@2|Bacteria,1TRWJ@1239|Firmicutes,24A2J@186801|Clostridia 186801|Clostridia M Peptidase, M23 - - - - - - - - - - - - G5,LysM,Peptidase_M23 LANLAPFM_01126 622312.ROSEINA2194_01459 1.08e-274 755.0 COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia 186801|Clostridia M Belongs to the EPSP synthase family. MurA subfamily murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase LANLAPFM_01128 1256908.HMPREF0373_02800 5.92e-84 257.0 COG3619@1|root,COG3619@2|Bacteria,1VBGA@1239|Firmicutes,24KG3@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF1275 LANLAPFM_01129 585394.RHOM_02270 6.81e-156 449.0 COG2206@1|root,COG2206@2|Bacteria,1TR95@1239|Firmicutes,25AZS@186801|Clostridia 186801|Clostridia T PFAM metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - HD,HD_5 LANLAPFM_01130 585394.RHOM_02275 2.38e-273 749.0 COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,248QF@186801|Clostridia 186801|Clostridia H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N LANLAPFM_01131 622312.ROSEINA2194_02776 8.95e-34 123.0 COG1846@1|root,COG1846@2|Bacteria,1VGEP@1239|Firmicutes,24QRJ@186801|Clostridia 186801|Clostridia K Transcriptional regulator, MarR family - - - - - - - - - - - - MarR LANLAPFM_01132 585394.RHOM_08900 0.0 1132.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia 186801|Clostridia V Abc transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_01133 622312.ROSEINA2194_02774 0.0 1030.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_01134 622312.ROSEINA2194_02772 4.64e-193 540.0 COG0039@1|root,COG0039@2|Bacteria,1TPSY@1239|Firmicutes,248DH@186801|Clostridia 186801|Clostridia C Belongs to the LDH MDH superfamily. LDH family - - - - - - - - - - - - Ldh_1_C,Ldh_1_N LANLAPFM_01135 585394.RHOM_08885 8.55e-163 468.0 COG1442@1|root,COG1442@2|Bacteria,1U86V@1239|Firmicutes,24CPG@186801|Clostridia 186801|Clostridia M Domain of unknown function (DUF4422) - - - - - - - - - - - - DUF4422 LANLAPFM_01139 622312.ROSEINA2194_03381 5.37e-289 790.0 COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia 186801|Clostridia E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT LANLAPFM_01140 1235790.C805_00793 3.64e-36 124.0 COG3326@1|root,COG3326@2|Bacteria,1VEJY@1239|Firmicutes,24QJW@186801|Clostridia,25XSB@186806|Eubacteriaceae 186801|Clostridia S Protein of unknown function (DUF1294) - - - - - - - - - - - - DUF1294 LANLAPFM_01141 585394.RHOM_11730 0.0 1073.0 COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,1TQVT@1239|Firmicutes,247X8@186801|Clostridia 186801|Clostridia U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG LANLAPFM_01142 585394.RHOM_11735 1.77e-314 858.0 COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,248DD@186801|Clostridia 186801|Clostridia C Radical SAM scfB - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM LANLAPFM_01143 622312.ROSEINA2194_02127 5.86e-175 498.0 COG0707@1|root,COG0707@2|Bacteria,1UQ6A@1239|Firmicutes,248FR@186801|Clostridia 186801|Clostridia M Monogalactosyldiacylglycerol synthase - - 2.4.1.315 ko:K03429 ko00561,ko01100,map00561,map01100 - R02689,R04377 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003 - GT28 - Glyco_tran_28_C,Glycos_transf_1,MGDG_synth LANLAPFM_01144 622312.ROSEINA2194_02128 2.8e-76 234.0 COG0344@1|root,COG0344@2|Bacteria,1V798@1239|Firmicutes,24KR2@186801|Clostridia 186801|Clostridia I Belongs to the PlsY family - - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf LANLAPFM_01145 585394.RHOM_13085 2.97e-211 583.0 COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia 186801|Clostridia E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24,SEC-C LANLAPFM_01146 585394.RHOM_13095 4.32e-80 239.0 COG1610@1|root,COG1610@2|Bacteria,1V6F2@1239|Firmicutes,24JB0@186801|Clostridia 186801|Clostridia S YqeY-like protein yqeY - - ko:K09117 - - - - ko00000 - - - YqeY LANLAPFM_01147 622312.ROSEINA2194_02132 2.08e-107 331.0 COG0791@1|root,COG3883@1|root,COG0791@2|Bacteria,COG3883@2|Bacteria,1UVYK@1239|Firmicutes,249G6@186801|Clostridia 186801|Clostridia M NlpC p60 family - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60 LANLAPFM_01148 585394.RHOM_13110 3.04e-229 648.0 COG1388@1|root,COG1388@2|Bacteria,1TSVC@1239|Firmicutes,248VQ@186801|Clostridia 186801|Clostridia M LysM domain - - - - - - - - - - - - DUF3794,LysM LANLAPFM_01149 585394.RHOM_13115 1.26e-46 150.0 COG4466@1|root,COG4466@2|Bacteria 2|Bacteria S Protein conserved in bacteria veg - - - - - - - - - - - VEG LANLAPFM_01150 1226325.HMPREF1548_00183 3.27e-258 718.0 COG4209@1|root,COG4209@2|Bacteria,1TSTC@1239|Firmicutes,24AFM@186801|Clostridia,36FY9@31979|Clostridiaceae 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - BPD_transp_1 LANLAPFM_01151 1226325.HMPREF1548_00184 3.1e-203 565.0 COG0395@1|root,COG0395@2|Bacteria,1TRB1@1239|Firmicutes,2488P@186801|Clostridia,36F12@31979|Clostridiaceae 186801|Clostridia G Psort location CytoplasmicMembrane, score 10.00 - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 LANLAPFM_01152 658086.HMPREF0994_06596 0.0 948.0 COG1653@1|root,COG1653@2|Bacteria,1TPHG@1239|Firmicutes,24AFQ@186801|Clostridia,27J6A@186928|unclassified Lachnospiraceae 186801|Clostridia G ABC transporter substrate-binding protein - - - ko:K02027,ko:K17318 ko02010,map02010 M00207,M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.29,3.A.1.1.9 - - - LANLAPFM_01153 1469948.JPNB01000002_gene2805 1.94e-66 209.0 COG5578@1|root,COG5578@2|Bacteria,1VJNV@1239|Firmicutes,24SDJ@186801|Clostridia 186801|Clostridia S Protein of unknown function, DUF624 - - - - - - - - - - - - DUF624 LANLAPFM_01154 1469948.JPNB01000002_gene2802 0.0 1005.0 COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,2488V@186801|Clostridia,36FQ1@31979|Clostridiaceae 186801|Clostridia G beta-galactosidase - - 3.2.1.23 ko:K12308 ko00052,map00052 - R01105 RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M LANLAPFM_01155 1410622.JNKY01000019_gene1711 1.34e-244 684.0 COG3669@1|root,COG3669@2|Bacteria,1TT4V@1239|Firmicutes,24A0S@186801|Clostridia,27IVN@186928|unclassified Lachnospiraceae 186801|Clostridia G Alpha-L-fucosidase - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos,Fucosidase_C LANLAPFM_01156 573061.Clocel_0036 4.32e-122 380.0 COG2972@1|root,COG2972@2|Bacteria,1UY73@1239|Firmicutes,24AX8@186801|Clostridia,36G3Y@31979|Clostridiaceae 186801|Clostridia T Histidine kinase - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,His_kinase,dCache_1 LANLAPFM_01157 1280685.AUKC01000023_gene851 1.61e-182 532.0 COG1653@1|root,COG1653@2|Bacteria,1TQ1D@1239|Firmicutes,24AFW@186801|Clostridia,4BXI8@830|Butyrivibrio 186801|Clostridia G PFAM extracellular solute-binding protein family 1 - - - ko:K17318 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - SBP_bac_1,SBP_bac_8 LANLAPFM_01158 1280390.CBQR020000094_gene2073 7.13e-256 715.0 COG1492@1|root,COG1492@2|Bacteria,1TP5E@1239|Firmicutes,4HAQW@91061|Bacilli,26UJH@186822|Paenibacillaceae 91061|Bacilli H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,CbiA,GATase_3 LANLAPFM_01159 877420.ATVW01000017_gene1701 1.87e-139 408.0 COG2038@1|root,COG2038@2|Bacteria,1TPC1@1239|Firmicutes,25DH5@186801|Clostridia,27IYG@186928|unclassified Lachnospiraceae 186801|Clostridia H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) cobT - 2.4.2.21 ko:K00768 ko00860,ko01100,map00860,map01100 M00122 R04148 RC00033,RC00063 ko00000,ko00001,ko00002,ko01000 - - - DBI_PRT LANLAPFM_01160 1235793.C809_02443 1.16e-49 166.0 COG2087@1|root,COG2087@2|Bacteria,1V6F8@1239|Firmicutes,24JF6@186801|Clostridia,27M8T@186928|unclassified Lachnospiraceae 186801|Clostridia H Cobinamide kinase / cobinamide phosphate guanyltransferase cobU - 2.7.1.156,2.7.7.62 ko:K02231 ko00860,ko01100,map00860,map01100 M00122 R05221,R05222,R06558 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - CobU LANLAPFM_01161 1120746.CCNL01000008_gene545 5.02e-105 311.0 COG0368@1|root,COG0368@2|Bacteria 2|Bacteria H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008818,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CobS LANLAPFM_01162 537007.BLAHAN_05799 8.85e-29 108.0 COG2087@1|root,COG2087@2|Bacteria,1VG8S@1239|Firmicutes,24QSM@186801|Clostridia,3Y0HX@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - CobU LANLAPFM_01163 1120746.CCNL01000008_gene547 4.27e-71 222.0 COG0406@1|root,COG0406@2|Bacteria 2|Bacteria G alpha-ribazole phosphatase activity cobC - 3.1.3.73,6.3.1.10 ko:K02226,ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R04594,R06529,R07302,R11173 RC00017,RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 LANLAPFM_01164 622312.ROSEINA2194_01858 9.21e-140 405.0 COG1270@1|root,COG1270@2|Bacteria,1TQ3X@1239|Firmicutes,247PR@186801|Clostridia 186801|Clostridia H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib LANLAPFM_01165 689781.AUJX01000003_gene2930 1.88e-80 241.0 COG3467@1|root,COG3467@2|Bacteria,1V6NS@1239|Firmicutes,24JA3@186801|Clostridia,2PSHU@265975|Oribacterium 186801|Clostridia S Pyridoxamine 5'-phosphate oxidase nimA - - ko:K07005 - - - - ko00000 - - - Pyridox_ox_2 LANLAPFM_01166 622312.ROSEINA2194_02722 7.14e-30 111.0 2EKR7@1|root,33EEZ@2|Bacteria,1VQ0F@1239|Firmicutes,24UDN@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01167 585394.RHOM_08610 6.28e-69 214.0 COG2206@1|root,COG2206@2|Bacteria,1UI74@1239|Firmicutes,25EC7@186801|Clostridia 186801|Clostridia T metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - HD LANLAPFM_01168 585394.RHOM_08605 1.31e-158 458.0 COG4641@1|root,COG4641@2|Bacteria,1V642@1239|Firmicutes,24IV8@186801|Clostridia 186801|Clostridia S Protein conserved in bacteria - - - - - - - - - - - - Glyco_trans_1_2 LANLAPFM_01169 622312.ROSEINA2194_02720 7.62e-128 367.0 COG1636@1|root,COG1636@2|Bacteria,1TT7H@1239|Firmicutes,248EA@186801|Clostridia 186801|Clostridia C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queH - 1.17.99.6 ko:K09765 - - - - ko00000,ko01000,ko03016 - - - DUF208 LANLAPFM_01170 585394.RHOM_08595 2.25e-305 836.0 COG0165@1|root,COG0165@2|Bacteria,1TNZ6@1239|Firmicutes,2489H@186801|Clostridia 186801|Clostridia E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 LANLAPFM_01171 585394.RHOM_08590 3.99e-257 705.0 COG0136@1|root,COG0136@2|Bacteria,1TPC6@1239|Firmicutes,248ZR@186801|Clostridia 186801|Clostridia E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC LANLAPFM_01172 585394.RHOM_08585 4.27e-233 652.0 COG1672@1|root,COG1672@2|Bacteria,1TR21@1239|Firmicutes,24ADD@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - ko:K06921 - - - - ko00000 - - - ATPase_2,DUF234 LANLAPFM_01173 585394.RHOM_08580 0.0 2013.0 COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1TPJD@1239|Firmicutes,24810@186801|Clostridia 186801|Clostridia L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone traI - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim,Toprim_Crpt LANLAPFM_01174 622312.ROSEINA2194_01352 1.76e-146 414.0 COG1207@1|root,COG1207@2|Bacteria 2|Bacteria M glucosamine-1-phosphate N-acetyltransferase activity glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep LANLAPFM_01175 397287.C807_02675 1.18e-31 115.0 COG5658@1|root,COG5658@2|Bacteria,1VB6E@1239|Firmicutes,24MSY@186801|Clostridia,27NNV@186928|unclassified Lachnospiraceae 186801|Clostridia S SdpI/YhfL protein family - - - - - - - - - - - - SdpI LANLAPFM_01176 411467.BACCAP_02128 1.05e-89 270.0 28N6T@1|root,2ZBBM@2|Bacteria,1TS9F@1239|Firmicutes,24DPE@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01177 1408436.JHXY01000019_gene1391 4.51e-136 394.0 COG1307@1|root,COG1307@2|Bacteria,1TQDI@1239|Firmicutes,24ADT@186801|Clostridia,25W58@186806|Eubacteriaceae 186801|Clostridia S EDD domain protein, DegV family - - - - - - - - - - - - DegV LANLAPFM_01178 1280681.AUJZ01000005_gene3017 1.21e-109 333.0 COG0639@1|root,COG0639@2|Bacteria,1V2F7@1239|Firmicutes,24H5G@186801|Clostridia,4BWBP@830|Butyrivibrio 186801|Clostridia T Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos,Metallophos_2 LANLAPFM_01179 515620.EUBELI_20270 4.49e-85 253.0 COG2606@1|root,COG2606@2|Bacteria,1V3MU@1239|Firmicutes,24HH2@186801|Clostridia,25W9B@186806|Eubacteriaceae 186801|Clostridia S Aminoacyl-tRNA editing domain EbsC - - - - - - - - - - - tRNA_edit LANLAPFM_01180 515620.EUBELI_20602 2.94e-52 166.0 2CG7V@1|root,32S3C@2|Bacteria,1UIG6@1239|Firmicutes,25EMK@186801|Clostridia,25ZVA@186806|Eubacteriaceae 186801|Clostridia S Stress responsive A/B Barrel Domain - - - - - - - - - - - - DUF4298,Dabb LANLAPFM_01181 411489.CLOL250_01927 0.0 892.0 COG1757@1|root,COG1757@2|Bacteria,1TP8A@1239|Firmicutes,247V4@186801|Clostridia,36EFF@31979|Clostridiaceae 186801|Clostridia C Na H antiporter - - - - - - - - - - - - Na_H_antiporter LANLAPFM_01182 1280688.AUJB01000008_gene509 1.61e-163 468.0 COG1613@1|root,COG1613@2|Bacteria,1TS25@1239|Firmicutes,24B9S@186801|Clostridia,3NI27@46205|Pseudobutyrivibrio 186801|Clostridia P PBP superfamily domain sbp - - ko:K02048 ko00920,ko02010,map00920,map02010 M00185 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3 - - SBP_bac_11 LANLAPFM_01183 515620.EUBELI_01885 1.18e-156 444.0 COG0555@1|root,COG0555@2|Bacteria,1TQHR@1239|Firmicutes,24ACM@186801|Clostridia,25ZFW@186806|Eubacteriaceae 186801|Clostridia O Binding-protein-dependent transport system inner membrane component cysT - - ko:K02046,ko:K15496 ko00920,ko02010,map00920,map02010 M00185,M00423 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3,3.A.1.6.5 - - BPD_transp_1 LANLAPFM_01184 515620.EUBELI_01884 3.36e-150 427.0 COG4208@1|root,COG4208@2|Bacteria,1TS3N@1239|Firmicutes,24C3X@186801|Clostridia,25VWA@186806|Eubacteriaceae 186801|Clostridia P Binding-protein-dependent transport system inner membrane component cysW - - ko:K02047 ko00920,ko02010,map00920,map02010 M00185 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3 - - BPD_transp_1 LANLAPFM_01185 515620.EUBELI_01883 2.58e-169 483.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,25W0F@186806|Eubacteriaceae 186801|Clostridia E Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system cysA - 3.6.3.25 ko:K02045,ko:K02052 ko00920,ko02010,ko02024,map00920,map02010,map02024 M00185,M00193 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11,3.A.1.6.1,3.A.1.6.3 - - ABC_tran,TOBE_2 LANLAPFM_01186 1121115.AXVN01000104_gene849 7.51e-279 778.0 COG1053@1|root,COG1053@2|Bacteria,1TRE8@1239|Firmicutes,247TH@186801|Clostridia,3Y0UM@572511|Blautia 186801|Clostridia C FAD binding domain aprA - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C LANLAPFM_01187 515620.EUBELI_01895 3.76e-50 160.0 COG1146@1|root,COG1146@2|Bacteria,1VADW@1239|Firmicutes,24MQA@186801|Clostridia,25X48@186806|Eubacteriaceae 186801|Clostridia C 4Fe-4S binding domain - - 1.8.99.2 ko:K00395 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_9 LANLAPFM_01188 585394.RHOM_05970 1.42e-210 601.0 COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1TSDF@1239|Firmicutes,250SJ@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,Response_reg,SnoaL_3 LANLAPFM_01189 397290.C810_02248 5.99e-21 84.0 29VDD@1|root,325Y2@2|Bacteria,1UHHD@1239|Firmicutes,25JIV@186801|Clostridia,27SCF@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01190 397290.C810_02249 1.73e-35 122.0 COG5577@1|root,COG5577@2|Bacteria,1TU9X@1239|Firmicutes,25IH5@186801|Clostridia,27S9B@186928|unclassified Lachnospiraceae 186801|Clostridia M Coat F domain - - - - - - - - - - - - Coat_F LANLAPFM_01191 585394.RHOM_05910 3.57e-52 167.0 2E4R1@1|root,32ZJK@2|Bacteria,1VEMY@1239|Firmicutes,24NDK@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - YgbA_NO LANLAPFM_01192 585394.RHOM_05915 2.31e-263 739.0 COG4988@1|root,COG4988@2|Bacteria,1TQ1P@1239|Firmicutes,248SV@186801|Clostridia 186801|Clostridia V Abc transporter cydD - - ko:K06147,ko:K06148 - - - - ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_01193 585394.RHOM_05920 1.6e-250 706.0 COG1132@1|root,COG1132@2|Bacteria,1UHQP@1239|Firmicutes,25E4H@186801|Clostridia 186801|Clostridia V abc transporter atp-binding protein cydC - - ko:K06148 - - - - ko00000,ko02000 3.A.1 - - ABC_membrane,ABC_tran LANLAPFM_01194 585394.RHOM_00395 3.7e-116 337.0 COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,24FTM@186801|Clostridia 186801|Clostridia P Plays a role in the regulation of phosphate uptake phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU LANLAPFM_01195 622312.ROSEINA2194_04399 5.18e-171 478.0 COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia 186801|Clostridia P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran LANLAPFM_01196 622312.ROSEINA2194_04398 1.23e-157 448.0 COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,248C4@186801|Clostridia 186801|Clostridia P phosphate transport system permease pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 LANLAPFM_01197 622312.ROSEINA2194_04397 8.2e-160 452.0 COG0573@1|root,COG0573@2|Bacteria,1TSPP@1239|Firmicutes,249KQ@186801|Clostridia 186801|Clostridia P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 LANLAPFM_01198 622312.ROSEINA2194_04395 1.47e-142 412.0 COG0226@1|root,COG0226@2|Bacteria,1TQ5X@1239|Firmicutes,248QU@186801|Clostridia 186801|Clostridia P phosphate binding protein pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 LANLAPFM_01199 585394.RHOM_00370 2.36e-107 316.0 COG2357@1|root,COG2357@2|Bacteria,1VDTE@1239|Firmicutes,24Q2S@186801|Clostridia 186801|Clostridia S RelA SpoT domain protein - - - - - - - - - - - - RelA_SpoT LANLAPFM_01200 622312.ROSEINA2194_04392 7.93e-45 156.0 COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes,24AVJ@186801|Clostridia 186801|Clostridia C glycerophosphoryl diester phosphodiesterase - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD LANLAPFM_01201 622312.ROSEINA2194_03721 1.69e-62 192.0 COG2868@1|root,COG2868@2|Bacteria 2|Bacteria J Cysteine protease Prp ysxB - - ko:K07584 - - - - ko00000 - - - Peptidase_Prp LANLAPFM_01202 622312.ROSEINA2194_03722 1.9e-61 188.0 COG0211@1|root,COG0211@2|Bacteria,1V6HW@1239|Firmicutes,24N3D@186801|Clostridia 186801|Clostridia J Belongs to the bacterial ribosomal protein bL27 family rpmA - - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 LANLAPFM_01203 585394.RHOM_07550 1.22e-290 795.0 COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,247SP@186801|Clostridia 186801|Clostridia S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - DUF1967,GTP1_OBG,MMR_HSR1 LANLAPFM_01204 585394.RHOM_07555 4.22e-51 162.0 COG1534@1|root,COG1534@2|Bacteria,1VEGM@1239|Firmicutes,24QZB@186801|Clostridia 186801|Clostridia J RNA-binding protein, YhbY family yhbY - - ko:K07574 - - - - ko00000,ko03009 - - - CRS1_YhbY LANLAPFM_01205 585394.RHOM_07560 7.66e-89 267.0 COG1057@1|root,COG1057@2|Bacteria,1V3SK@1239|Firmicutes,24JFM@186801|Clostridia 186801|Clostridia H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like LANLAPFM_01206 585394.RHOM_07565 8.96e-103 301.0 COG1713@1|root,COG1713@2|Bacteria,1V6Y1@1239|Firmicutes,24HN2@186801|Clostridia 186801|Clostridia H Hydrolase, HD family nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like,HD LANLAPFM_01207 585394.RHOM_07570 3.18e-63 194.0 COG0799@1|root,COG0799@2|Bacteria,1VA2Z@1239|Firmicutes,24MVA@186801|Clostridia 186801|Clostridia J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS LANLAPFM_01208 585394.RHOM_07575 1.09e-127 365.0 COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia 186801|Clostridia K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 LANLAPFM_01209 658086.HMPREF0994_02833 6.28e-20 85.1 COG1388@1|root,COG1388@2|Bacteria,1VK5T@1239|Firmicutes,24UT1@186801|Clostridia,27Q7D@186928|unclassified Lachnospiraceae 186801|Clostridia M LysM domain - - - - - - - - - - - - LysM LANLAPFM_01210 585394.RHOM_07585 1.32e-149 423.0 COG0204@1|root,COG0204@2|Bacteria,1TTPK@1239|Firmicutes,24B6K@186801|Clostridia 186801|Clostridia I Psort location Cytoplasmic, score 8.87 - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase LANLAPFM_01211 585394.RHOM_07685 0.0 1333.0 COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,2480Z@186801|Clostridia 186801|Clostridia M penicillin-binding protein mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase LANLAPFM_01212 585394.RHOM_07675 4.57e-120 351.0 COG2894@1|root,COG2894@2|Bacteria,1TP6P@1239|Firmicutes,249BB@186801|Clostridia 186801|Clostridia D Belongs to the ParA family minD - - ko:K03609 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA,ParA LANLAPFM_01213 622312.ROSEINA2194_03759 1.23e-16 73.6 COG0851@1|root,COG0851@2|Bacteria 2|Bacteria D regulation of division septum assembly minE - - ko:K03608 - - - - ko00000,ko03036,ko04812 - - - MinE LANLAPFM_01214 585394.RHOM_07665 1.95e-196 551.0 COG0772@1|root,COG0772@2|Bacteria,1TPGH@1239|Firmicutes,247WS@186801|Clostridia 186801|Clostridia D Belongs to the SEDS family rodA - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE LANLAPFM_01215 585394.RHOM_07660 8.95e-91 265.0 COG1803@1|root,COG1803@2|Bacteria,1V3KQ@1239|Firmicutes,24FUQ@186801|Clostridia 186801|Clostridia G methylglyoxal synthase mgsA - 4.2.3.3 ko:K01734 ko00640,ko01120,map00640,map01120 - R01016 RC00424 ko00000,ko00001,ko01000 - - - MGS LANLAPFM_01216 585394.RHOM_16890 2.79e-127 367.0 COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,247WM@186801|Clostridia 186801|Clostridia J Specifically methylates the N7 position of a guanine in 16S rRNA rsmG - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB LANLAPFM_01217 622312.ROSEINA2194_03228 0.0 1119.0 COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,247U2@186801|Clostridia 186801|Clostridia D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc LANLAPFM_01218 622312.ROSEINA2194_03229 5.01e-273 753.0 COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,248A9@186801|Clostridia 186801|Clostridia S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N LANLAPFM_01219 622312.ROSEINA2194_03230 1.05e-118 342.0 COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia 186801|Clostridia S R3H domain protein jag - - ko:K06346 - - - - ko00000 - - - Jag_N,KH_4,R3H LANLAPFM_01220 585394.RHOM_16915 1.43e-218 613.0 COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,247V9@186801|Clostridia 186801|Clostridia U Membrane protein insertase, YidC Oxa1 family yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP LANLAPFM_01221 585394.RHOM_16925 3.33e-65 199.0 COG0594@1|root,COG0594@2|Bacteria,1VA78@1239|Firmicutes,24QK5@186801|Clostridia 186801|Clostridia J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P LANLAPFM_01222 585394.RHOM_16930 3.25e-20 80.9 COG0230@1|root,COG0230@2|Bacteria,1VK90@1239|Firmicutes,24UGN@186801|Clostridia 186801|Clostridia J Belongs to the bacterial ribosomal protein bL34 family rpmH - - ko:K02914 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L34 LANLAPFM_01223 622312.ROSEINA2194_03235 2.31e-296 812.0 COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia 186801|Clostridia L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N LANLAPFM_01224 585394.RHOM_00010 3.22e-248 683.0 COG0592@1|root,COG0592@2|Bacteria,1TQ7J@1239|Firmicutes,248EG@186801|Clostridia 186801|Clostridia L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 LANLAPFM_01225 585394.RHOM_00015 1.32e-35 121.0 COG2501@1|root,COG2501@2|Bacteria 2|Bacteria S S4 domain yaaA GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K14761 - - - - ko00000,ko03009 - - - S4_2 LANLAPFM_01226 622312.ROSEINA2194_03238 4.33e-214 597.0 COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,247KY@186801|Clostridia 186801|Clostridia L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N LANLAPFM_01227 585394.RHOM_00025 0.0 1207.0 COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia 186801|Clostridia L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim LANLAPFM_01228 585394.RHOM_00030 0.0 1509.0 COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia 186801|Clostridia L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV LANLAPFM_01229 537007.BLAHAN_05724 2e-156 450.0 COG3550@1|root,COG3550@2|Bacteria,1UYFT@1239|Firmicutes,24C8G@186801|Clostridia,3Y2EV@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - LANLAPFM_01231 1280692.AUJL01000002_gene2728 7.37e-85 280.0 COG1132@1|root,COG1132@2|Bacteria,1V2WX@1239|Firmicutes,24GV7@186801|Clostridia,36R7T@31979|Clostridiaceae 186801|Clostridia V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran LANLAPFM_01232 1123075.AUDP01000012_gene3562 8.46e-53 171.0 COG3279@1|root,COG3279@2|Bacteria,1VEPW@1239|Firmicutes,24K2U@186801|Clostridia 186801|Clostridia K LytTr DNA-binding domain protein - - - - - - - - - - - - LytTR LANLAPFM_01233 742740.HMPREF9474_01564 7.2e-53 171.0 2AH77@1|root,317H3@2|Bacteria,1V6I2@1239|Firmicutes,24KDW@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF3021) - - - - - - - - - - - - DUF3021 LANLAPFM_01234 658086.HMPREF0994_06595 0.0 1182.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,27JWP@186928|unclassified Lachnospiraceae 186801|Clostridia G Glycosyl hydrolase family 3 C-terminal domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - CBM_6,Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C LANLAPFM_01235 585394.RHOM_00040 4.27e-109 325.0 COG5495@1|root,COG5495@2|Bacteria,1UZZU@1239|Firmicutes,249YF@186801|Clostridia 186801|Clostridia S NADP oxidoreductase coenzyme F420-dependent - - - - - - - - - - - - DUF2520,F420_oxidored,Rossmann-like LANLAPFM_01236 585394.RHOM_00045 4.69e-175 490.0 COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia 186801|Clostridia H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf LANLAPFM_01237 585394.RHOM_00050 3.65e-173 486.0 COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,248AN@186801|Clostridia 186801|Clostridia H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase LANLAPFM_01238 585394.RHOM_00055 1.39e-68 209.0 COG0853@1|root,COG0853@2|Bacteria,1V6NQ@1239|Firmicutes,24JVN@186801|Clostridia 186801|Clostridia H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox LANLAPFM_01239 622312.ROSEINA2194_03241 7.03e-127 374.0 COG0840@1|root,COG4905@1|root,COG0840@2|Bacteria,COG4905@2|Bacteria,1V2HX@1239|Firmicutes,24B3D@186801|Clostridia 186801|Clostridia D Psort location CytoplasmicMembrane, score - - - - - - - - - - - - ABC_trans_CmpB LANLAPFM_01240 622312.ROSEINA2194_03242 3.22e-169 476.0 COG1951@1|root,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,248T7@186801|Clostridia 186801|Clostridia C Fe-S type, tartrate fumarate subfamily, alpha fumA - 4.2.1.2 ko:K01677 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase LANLAPFM_01241 622312.ROSEINA2194_03243 3.69e-118 340.0 COG1838@1|root,COG1838@2|Bacteria,1V1CP@1239|Firmicutes,24FRK@186801|Clostridia 186801|Clostridia C Fe-S type, tartrate fumarate subfamily, beta fumB - 4.2.1.2 ko:K01678 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase_C LANLAPFM_01242 585394.RHOM_00105 5.38e-178 503.0 COG0673@1|root,COG0673@2|Bacteria,1TPT5@1239|Firmicutes,248MV@186801|Clostridia 186801|Clostridia E Oxidoreductase NAD-binding domain protein - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C LANLAPFM_01243 585394.RHOM_00255 1.64e-63 199.0 2C3ZC@1|root,32RD1@2|Bacteria,1V6CS@1239|Firmicutes,24P5Q@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01244 585394.RHOM_00260 7.22e-285 782.0 COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia 186801|Clostridia V Mate efflux family protein - - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE LANLAPFM_01245 585394.RHOM_00265 1.59e-184 515.0 COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1UZ35@1239|Firmicutes,25BI3@186801|Clostridia 186801|Clostridia K COG2207 AraC-type DNA-binding domain-containing proteins - - - - - - - - - - - - AraC_binding,HTH_18 LANLAPFM_01246 1408312.JNJS01000004_gene2375 7.78e-170 476.0 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,3NGQJ@46205|Pseudobutyrivibrio 186801|Clostridia I Enoyl-CoA hydratase/isomerase crt - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 LANLAPFM_01247 585394.RHOM_11880 4.76e-255 702.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia 186801|Clostridia E PFAM aminotransferase class I and II yugH - - ko:K10907 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 LANLAPFM_01248 622312.ROSEINA2194_00542 2.9e-186 528.0 COG1194@1|root,COG1194@2|Bacteria,1TPUT@1239|Firmicutes,25E4K@186801|Clostridia 186801|Clostridia L A G-specific adenine glycosylase mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4,SfsA LANLAPFM_01249 1121296.JONJ01000004_gene974 3.73e-50 162.0 COG5496@1|root,COG5496@2|Bacteria,1VAZJ@1239|Firmicutes,24MWR@186801|Clostridia,222ZV@1506553|Lachnoclostridium 186801|Clostridia S Thioesterase superfamily - - 3.1.2.29 ko:K18700 - - - - ko00000,ko01000 - - - 4HBT LANLAPFM_01250 357809.Cphy_0713 9.01e-137 392.0 COG0428@1|root,COG0428@2|Bacteria,1TP7J@1239|Firmicutes,247Q2@186801|Clostridia,21Y17@1506553|Lachnoclostridium 186801|Clostridia P Psort location CytoplasmicMembrane, score 9.99 - - - ko:K07238 - - - - ko00000,ko02000 2.A.5.5 - - Zip LANLAPFM_01251 585394.RHOM_05995 3.28e-61 189.0 2F3F9@1|root,33W92@2|Bacteria,1VVFD@1239|Firmicutes,25130@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01252 585394.RHOM_06000 7.1e-82 253.0 COG1434@1|root,COG1434@2|Bacteria,1VA42@1239|Firmicutes,24HKK@186801|Clostridia 186801|Clostridia O Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF218 LANLAPFM_01253 622312.ROSEINA2194_01565 8.5e-97 287.0 COG0328@1|root,COG3341@1|root,COG0328@2|Bacteria,COG3341@2|Bacteria,1V442@1239|Firmicutes,24HSE@186801|Clostridia 186801|Clostridia L Ribonuclease HI rnhA - 3.1.26.4 ko:K03469,ko:K06993 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Cauli_VI,RNase_H LANLAPFM_01254 585394.RHOM_06010 3.21e-198 557.0 COG1609@1|root,COG1609@2|Bacteria,1TP9Q@1239|Firmicutes,24ARJ@186801|Clostridia 186801|Clostridia K Periplasmic binding protein LacI transcriptional regulator araR - - ko:K02103 - - - - ko00000,ko03000 - - - GntR,Peripla_BP_3 LANLAPFM_01255 622312.ROSEINA2194_02626 1.73e-85 255.0 COG0602@1|root,COG0602@2|Bacteria,1V1HG@1239|Firmicutes,24HIJ@186801|Clostridia 186801|Clostridia O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine nrdG - 1.97.1.4 ko:K04068 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM LANLAPFM_01257 585394.RHOM_04880 1.21e-114 346.0 COG0727@1|root,COG0727@2|Bacteria,1TSB6@1239|Firmicutes,24AQ9@186801|Clostridia 186801|Clostridia S N-methylation of lysine residues in flagellin K00599 - - - ko:K18475 - - - - ko00000,ko01000,ko02035 - - - CxxCxxCC LANLAPFM_01259 626939.HMPREF9443_00657 3.17e-295 819.0 COG4637@1|root,COG4637@2|Bacteria,1TQ9X@1239|Firmicutes,4H6HU@909932|Negativicutes 909932|Negativicutes S Predicted AAA-ATPase - - - - - - - - - - - - AAA-ATPase_like,PDDEXK_9 LANLAPFM_01260 397291.C804_04198 3.21e-197 628.0 COG0366@1|root,COG1523@1|root,COG3209@1|root,COG0366@2|Bacteria,COG1523@2|Bacteria,COG3209@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia,27K0D@186928|unclassified Lachnospiraceae 186801|Clostridia G Carbohydrate-binding module 48 (Isoamylase N-terminal domain) pulA - 3.2.1.41 ko:K01200 ko00500,ko01100,ko01110,map00500,map01100,map01110 - R02111 - ko00000,ko00001,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3372,PUD LANLAPFM_01264 585394.RHOM_05225 6.79e-189 532.0 COG0630@1|root,COG0630@2|Bacteria,1UHT2@1239|Firmicutes,25EN1@186801|Clostridia 186801|Clostridia NU COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis - - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE LANLAPFM_01265 585394.RHOM_05230 3.38e-160 472.0 28I5Y@1|root,2Z892@2|Bacteria,1UYUF@1239|Firmicutes,24CM9@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01266 397288.C806_03858 4.48e-19 82.8 2EG0W@1|root,339SX@2|Bacteria,1VKDR@1239|Firmicutes,24TDP@186801|Clostridia,27QMZ@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01270 622312.ROSEINA2194_03514 0.0 2590.0 COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1TPU5@1239|Firmicutes,2481F@186801|Clostridia 186801|Clostridia I CoA-substrate-specific enzyme activase hgdC2 - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D LANLAPFM_01271 585394.RHOM_06185 1.76e-154 439.0 COG0705@1|root,COG0705@2|Bacteria,1TSBP@1239|Firmicutes,249D8@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Rhomboid LANLAPFM_01272 622312.ROSEINA2194_04095 6.62e-132 382.0 COG2816@1|root,COG2816@2|Bacteria,1TRMF@1239|Firmicutes,24AXA@186801|Clostridia 186801|Clostridia L Psort location Cytoplasmic, score nudC - 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 - R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 - - - NUDIX,NUDIX-like,zf-NADH-PPase LANLAPFM_01273 585394.RHOM_11020 4.06e-172 499.0 COG0845@1|root,COG0845@2|Bacteria,1V4XJ@1239|Firmicutes,25CIU@186801|Clostridia 186801|Clostridia M Efflux transporter, RND family, MFP subunit - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP LANLAPFM_01274 585394.RHOM_11015 9.49e-147 415.0 COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran LANLAPFM_01275 585394.RHOM_11010 7.74e-244 678.0 COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia 186801|Clostridia V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD LANLAPFM_01276 585394.RHOM_06145 2.57e-143 410.0 COG0726@1|root,COG0726@2|Bacteria,1TT1X@1239|Firmicutes,249PF@186801|Clostridia 186801|Clostridia G delta-lactam-biosynthetic de-N-acetylase pdaA - - ko:K01567 - - - - ko00000,ko01000 - - - Polysacc_deac_1 LANLAPFM_01277 1235790.C805_00453 1.12e-51 197.0 COG5279@1|root,COG5279@2|Bacteria 2|Bacteria D protein involved in cytokinesis, contains TGc (transglutaminase protease-like) domain - - - - - - - - - - - - CHB_HEX_C_1,Flg_new LANLAPFM_01278 622312.ROSEINA2194_02750 3.38e-43 145.0 2FBHF@1|root,343NR@2|Bacteria,1W0XC@1239|Firmicutes,253BM@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01279 585394.RHOM_05270 1.21e-226 633.0 COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia 186801|Clostridia M Cbs domain - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 LANLAPFM_01280 622312.ROSEINA2194_00306 0.0 906.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia 186801|Clostridia F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO LANLAPFM_01281 397290.C810_04420 2.48e-134 386.0 COG0106@1|root,COG0106@2|Bacteria,1TPIN@1239|Firmicutes,249HJ@186801|Clostridia,27IKR@186928|unclassified Lachnospiraceae 186801|Clostridia E Histidine biosynthesis protein hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth LANLAPFM_01282 585394.RHOM_05285 9.35e-294 805.0 COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia 186801|Clostridia E glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N LANLAPFM_01283 585394.RHOM_05290 1.51e-104 304.0 COG3707@1|root,COG3707@2|Bacteria,1V2S1@1239|Firmicutes,24EWG@186801|Clostridia 186801|Clostridia K ANTAR domain protein - - - ko:K22010 - M00839 - - ko00000,ko00002,ko02022 - - - ANTAR LANLAPFM_01284 622312.ROSEINA2194_02823 5.03e-225 624.0 COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,24998@186801|Clostridia 186801|Clostridia E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt LANLAPFM_01285 585394.RHOM_06195 3.41e-207 585.0 COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia 186801|Clostridia E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase LANLAPFM_01286 585394.RHOM_06200 2.45e-268 735.0 COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia 186801|Clostridia J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT LANLAPFM_01287 585394.RHOM_06205 5.55e-53 168.0 COG1862@1|root,COG1862@2|Bacteria,1VEMC@1239|Firmicutes,24MMT@186801|Clostridia 186801|Clostridia U Preprotein translocase, YajC subunit yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC LANLAPFM_01288 397291.C804_00163 2.97e-34 134.0 2DY23@1|root,347RM@2|Bacteria,1VQMX@1239|Firmicutes,24UP2@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01289 1235800.C819_02255 1.74e-144 431.0 COG0270@1|root,COG0270@2|Bacteria,1TQS8@1239|Firmicutes,24DG1@186801|Clostridia,27M09@186928|unclassified Lachnospiraceae 186801|Clostridia L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase LANLAPFM_01294 411461.DORFOR_02986 3.02e-105 323.0 COG0582@1|root,COG0582@2|Bacteria,1V1QX@1239|Firmicutes,24H7Y@186801|Clostridia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Phage_integrase LANLAPFM_01295 556261.HMPREF0240_01005 1.13e-121 366.0 COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,36DFY@31979|Clostridiaceae 186801|Clostridia L domain protein - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Ada_Zn_binding,Lactamase_B LANLAPFM_01296 622312.ROSEINA2194_02986 6.42e-106 308.0 COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia 186801|Clostridia I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 2.7.7.60,4.6.1.12 ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD,YgbB LANLAPFM_01297 1235799.C818_01516 1.21e-175 543.0 COG3210@1|root,COG3210@2|Bacteria,1UJX3@1239|Firmicutes,25FCY@186801|Clostridia,27IUC@186928|unclassified Lachnospiraceae 186801|Clostridia U domain, Protein - - - - - - - - - - - - fn3 LANLAPFM_01298 1280671.AUJH01000002_gene1825 4.5e-40 156.0 COG2199@1|root,COG3706@2|Bacteria,1TSW8@1239|Firmicutes,249J7@186801|Clostridia,4C1VP@830|Butyrivibrio 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - GGDEF,Response_reg LANLAPFM_01299 622312.ROSEINA2194_02987 3.33e-144 409.0 COG1045@1|root,COG1045@2|Bacteria,1TR42@1239|Firmicutes,249SF@186801|Clostridia 186801|Clostridia E serine acetyltransferase cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N LANLAPFM_01300 585394.RHOM_11205 3.68e-313 856.0 COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia 186801|Clostridia J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g LANLAPFM_01301 585394.RHOM_11200 3.62e-85 252.0 COG1939@1|root,COG1939@2|Bacteria,1VA5V@1239|Firmicutes,24MR1@186801|Clostridia 186801|Clostridia J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) mrnC - - ko:K11145 - - - - ko00000,ko01000,ko03009 - - - Ribonuclease_3 LANLAPFM_01302 585394.RHOM_11195 2.3e-161 454.0 COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,247SC@186801|Clostridia 186801|Clostridia J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family yacO - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind LANLAPFM_01303 622312.ROSEINA2194_02991 2.42e-90 271.0 COG1595@1|root,COG1595@2|Bacteria,1TP55@1239|Firmicutes,249VX@186801|Clostridia 186801|Clostridia K Belongs to the sigma-70 factor family sigH - - ko:K03091 - - - - ko00000,ko03021 - - - GerE,Sigma70_r2,Sigma70_r4_2 LANLAPFM_01304 585394.RHOM_11185 2.21e-308 842.0 COG0422@1|root,COG0422@2|Bacteria,1TNZ3@1239|Firmicutes,247JE@186801|Clostridia 186801|Clostridia H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC_Rad_SAM LANLAPFM_01305 585394.RHOM_11180 1.69e-78 261.0 2E03H@1|root,33IG6@2|Bacteria,1VKD9@1239|Firmicutes,24TED@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01308 585394.RHOM_05035 1.04e-282 794.0 COG1368@1|root,COG1368@2|Bacteria,1TRMA@1239|Firmicutes,2480C@186801|Clostridia 186801|Clostridia M PFAM sulfatase - - - - - - - - - - - - Sulfatase LANLAPFM_01309 622312.ROSEINA2194_00030 0.0 1013.0 COG4485@1|root,COG4485@2|Bacteria,1TRR1@1239|Firmicutes,24BHM@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - GtrA,YfhO LANLAPFM_01310 622312.ROSEINA2194_00032 6.35e-100 290.0 COG0824@1|root,COG0824@2|Bacteria,1VAGM@1239|Firmicutes,24NBX@186801|Clostridia 186801|Clostridia S acyl-CoA thioester hydrolase, YbgC YbaW family FcbC - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 LANLAPFM_01311 585394.RHOM_09960 0.0 1071.0 COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia 186801|Clostridia E creatinase pepQ - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C LANLAPFM_01312 585394.RHOM_09955 0.0 1439.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia 186801|Clostridia L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 LANLAPFM_01313 622312.ROSEINA2194_00035 3.2e-92 275.0 COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,24GFQ@186801|Clostridia 186801|Clostridia H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE - 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE LANLAPFM_01314 585394.RHOM_09945 0.0 1017.0 COG0849@1|root,COG0849@2|Bacteria,1TP1Z@1239|Firmicutes,249Y7@186801|Clostridia 186801|Clostridia D cell division protein FtsA ftsA - - - - - - - - - - - FtsA,MreB_Mbl LANLAPFM_01315 585394.RHOM_09940 3.45e-156 442.0 COG1235@1|root,COG1235@2|Bacteria,1TQ8E@1239|Firmicutes,249U2@186801|Clostridia 186801|Clostridia J Metallo-beta-lactamase domain protein yycJ - - - - - - - - - - - Lactamase_B,Lactamase_B_2 LANLAPFM_01316 585394.RHOM_09930 1.51e-49 158.0 COG3830@1|root,COG3830@2|Bacteria,1VENW@1239|Firmicutes,24QNV@186801|Clostridia 186801|Clostridia T Belongs to the UPF0237 family - - - ko:K07166 - - - - ko00000 - - - ACT_6 LANLAPFM_01317 585394.RHOM_09925 2.16e-300 822.0 COG2848@1|root,COG2848@2|Bacteria,1TQG8@1239|Firmicutes,247K4@186801|Clostridia 186801|Clostridia S UPF0210 protein - - - ko:K09157 - - - - ko00000 - - - DUF711 LANLAPFM_01318 585394.RHOM_09920 3.23e-137 405.0 COG4641@1|root,COG4641@2|Bacteria,1UYE0@1239|Firmicutes,24D1Q@186801|Clostridia 186801|Clostridia M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_2 LANLAPFM_01319 622312.ROSEINA2194_00040 2.45e-154 435.0 COG3363@1|root,COG3363@2|Bacteria,1TRA7@1239|Firmicutes,249ZW@186801|Clostridia 186801|Clostridia F IMP cyclohydrolase-like protein - - - - - - - - - - - - IMP_cyclohyd LANLAPFM_01320 585394.RHOM_09910 7.05e-270 740.0 COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia 186801|Clostridia F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas LANLAPFM_01321 622312.ROSEINA2194_00044 1.78e-134 400.0 COG1323@1|root,COG1323@2|Bacteria,1TPP2@1239|Firmicutes,247UP@186801|Clostridia 186801|Clostridia S Belongs to the UPF0348 family - - - - - - - - - - - - HIGH_NTase1 LANLAPFM_01322 585394.RHOM_09880 2.45e-254 701.0 COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia 186801|Clostridia F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase LANLAPFM_01323 622312.ROSEINA2194_00046 5.07e-95 280.0 COG1399@1|root,COG1399@2|Bacteria,1VEXU@1239|Firmicutes,24RKT@186801|Clostridia 186801|Clostridia S acr, cog1399 - - - ko:K07040 - - - - ko00000 - - - DUF177 LANLAPFM_01324 585394.RHOM_09870 5.07e-39 129.0 COG0333@1|root,COG0333@2|Bacteria,1VEFI@1239|Firmicutes,24QM0@186801|Clostridia 186801|Clostridia J Belongs to the bacterial ribosomal protein bL32 family rpmF - - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p LANLAPFM_01325 585394.RHOM_09855 7.1e-80 246.0 COG5578@1|root,COG5578@2|Bacteria,1V91Z@1239|Firmicutes,24KZS@186801|Clostridia 186801|Clostridia S Protein of unknown function, DUF624 - - - - - - - - - - - - DUF624 LANLAPFM_01326 622312.ROSEINA2194_00049 1.1e-220 612.0 COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,247KW@186801|Clostridia 186801|Clostridia I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis LANLAPFM_01327 585394.RHOM_09845 1.51e-41 137.0 COG0236@1|root,COG0236@2|Bacteria,1VEE3@1239|Firmicutes,24QME@186801|Clostridia 186801|Clostridia IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding LANLAPFM_01328 622312.ROSEINA2194_00051 1.2e-129 372.0 COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,249QD@186801|Clostridia 186801|Clostridia J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc - 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm LANLAPFM_01329 585394.RHOM_09830 0.0 1575.0 COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,249F4@186801|Clostridia 186801|Clostridia D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge LANLAPFM_01330 622312.ROSEINA2194_00054 3.1e-199 555.0 COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,247JD@186801|Clostridia 186801|Clostridia U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N LANLAPFM_01331 585394.RHOM_09820 4.35e-265 729.0 COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,248D5@186801|Clostridia 186801|Clostridia E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - ACT,PALP LANLAPFM_01333 585394.RHOM_09805 1.83e-62 193.0 COG2739@1|root,COG2739@2|Bacteria,1VEGP@1239|Firmicutes,24QNM@186801|Clostridia 186801|Clostridia S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein - - - ko:K09787 - - - - ko00000 - - - UPF0122 LANLAPFM_01334 622312.ROSEINA2194_00060 3.66e-271 748.0 COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia 186801|Clostridia U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB LANLAPFM_01335 622312.ROSEINA2194_00061 1.71e-49 157.0 COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,24MND@186801|Clostridia 186801|Clostridia J Belongs to the bacterial ribosomal protein bS16 family rpsP - - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 LANLAPFM_01336 585394.RHOM_09790 9.6e-38 127.0 COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,24QKN@186801|Clostridia 186801|Clostridia S Belongs to the UPF0109 family ylqC - - ko:K06960 - - - - ko00000 - - - KH_4 LANLAPFM_01338 622312.ROSEINA2194_00063 3.49e-98 288.0 COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,24I1G@186801|Clostridia 186801|Clostridia J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM LANLAPFM_01339 622312.ROSEINA2194_00064 4.53e-145 412.0 COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,247JF@186801|Clostridia 186801|Clostridia J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT LANLAPFM_01340 585394.RHOM_09775 7.46e-72 216.0 COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,24J83@186801|Clostridia 186801|Clostridia J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 LANLAPFM_01342 411474.COPEUT_00135 8.9e-86 268.0 COG1670@1|root,COG3393@1|root,COG1670@2|Bacteria,COG3393@2|Bacteria,1V1G4@1239|Firmicutes,24G4Y@186801|Clostridia 186801|Clostridia J Acetyltransferase, gnat family - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_3 LANLAPFM_01343 585394.RHOM_05295 2.66e-271 744.0 COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,24969@186801|Clostridia 186801|Clostridia E Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate dapL - 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 LANLAPFM_01344 1280694.AUJQ01000005_gene1348 5.3e-66 228.0 COG3437@1|root,COG3437@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia,3NGP7@46205|Pseudobutyrivibrio 186801|Clostridia KT HD domain - - - - - - - - - - - - HD,HD_5,HisKA_7TM LANLAPFM_01345 140626.JHWB01000019_gene917 1.07e-24 104.0 COG2214@1|root,COG2214@2|Bacteria,1V4YZ@1239|Firmicutes,24U0J@186801|Clostridia 186801|Clostridia O DnaJ molecular chaperone homology domain - - - - - - - - - - - - - LANLAPFM_01346 457412.RSAG_01565 4.01e-130 370.0 COG0560@1|root,COG0560@2|Bacteria,1TQJY@1239|Firmicutes,2493S@186801|Clostridia,3WH3X@541000|Ruminococcaceae 186801|Clostridia E phosphoserine phosphatase homoserine phosphotransferase bifunctional protein thrH - 2.7.1.39,3.1.3.3 ko:K02203 ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230 M00018 R00582,R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD,Hydrolase LANLAPFM_01347 1173026.Glo7428_1322 7.56e-52 179.0 COG0657@1|root,COG0657@2|Bacteria,1G229@1117|Cyanobacteria 1117|Cyanobacteria I PFAM alpha beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3,Peptidase_S9 LANLAPFM_01348 622312.ROSEINA2194_01130 9.3e-102 295.0 COG1854@1|root,COG1854@2|Bacteria,1V1CH@1239|Firmicutes,24G3R@186801|Clostridia 186801|Clostridia H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) luxS - 4.4.1.21 ko:K07173 ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111 M00609 R01291 RC00069,RC01929 ko00000,ko00001,ko00002,ko01000 - - - LuxS LANLAPFM_01349 585394.RHOM_04995 7.54e-119 347.0 COG0775@1|root,COG0775@2|Bacteria,1TSB7@1239|Firmicutes 1239|Firmicutes F COG0775 Nucleoside phosphorylase - - 3.2.2.9 ko:K01243 ko00270,ko01100,ko01230,map00270,map01100,map01230 M00034,M00609 R00194,R01401 RC00063,RC00318 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 LANLAPFM_01350 585394.RHOM_05430 3.6e-268 746.0 COG0765@1|root,COG0834@1|root,COG0765@2|Bacteria,COG0834@2|Bacteria,1TPM3@1239|Firmicutes,248UY@186801|Clostridia 186801|Clostridia P Abc transporter ArtM - - ko:K02029,ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1,SBP_bac_3 LANLAPFM_01351 622312.ROSEINA2194_01127 1.66e-153 434.0 COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,247QZ@186801|Clostridia 186801|Clostridia E abc transporter atp-binding protein glnQ - 3.6.3.21 ko:K02028 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran LANLAPFM_01353 585394.RHOM_05440 5.11e-219 606.0 COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,247VY@186801|Clostridia 186801|Clostridia J Ribosomal protein L11 methyltransferase prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA LANLAPFM_01354 585394.RHOM_05445 1.19e-107 318.0 COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,249VK@186801|Clostridia 186801|Clostridia J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA LANLAPFM_01355 585394.RHOM_05450 1.48e-220 615.0 COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia 186801|Clostridia E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 LANLAPFM_01356 585394.RHOM_05455 2.64e-268 736.0 COG0301@1|root,COG0301@2|Bacteria,1TPNW@1239|Firmicutes,247Y5@186801|Clostridia 186801|Clostridia H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS thiI - 2.8.1.4 ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07461 - ko00000,ko00001,ko01000,ko03016 - - - THUMP,ThiI LANLAPFM_01357 585394.RHOM_05460 4.54e-45 145.0 COG1925@1|root,COG1925@2|Bacteria,1VAQP@1239|Firmicutes,24N19@186801|Clostridia 186801|Clostridia G phosphocarrier protein HPr - - - - - - - - - - - - PTS-HPr LANLAPFM_01358 585394.RHOM_05465 2.26e-253 702.0 COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,247IX@186801|Clostridia 186801|Clostridia J MiaB-like tRNA modifying enzyme yqeV - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 LANLAPFM_01359 622312.ROSEINA2194_01033 1.4e-53 168.0 COG4472@1|root,COG4472@2|Bacteria,1VAC4@1239|Firmicutes,24QVQ@186801|Clostridia 186801|Clostridia S Belongs to the UPF0297 family yrzL - - - - - - - - - - - DUF965 LANLAPFM_01360 622312.ROSEINA2194_01034 3.21e-86 255.0 COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia 186801|Clostridia L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA yrrK - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX LANLAPFM_01361 622312.ROSEINA2194_01035 2.38e-36 124.0 2E3Y4@1|root,32YV4@2|Bacteria,1VFRH@1239|Firmicutes,24QXW@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF1292 LANLAPFM_01362 585394.RHOM_05485 0.0 1020.0 COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia 186801|Clostridia S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay rnj - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,Lactamase_B_2,RMMBL LANLAPFM_01363 622312.ROSEINA2194_01037 1e-47 155.0 COG3679@1|root,COG3679@2|Bacteria,1VH19@1239|Firmicutes,24RNC@186801|Clostridia 186801|Clostridia S Belongs to the UPF0342 family - - - - - - - - - - - - Com_YlbF LANLAPFM_01364 585394.RHOM_05490 4.65e-55 178.0 COG1559@1|root,COG1559@2|Bacteria,1VGA6@1239|Firmicutes,24RBR@186801|Clostridia 186801|Clostridia S YceG-like family - - - ko:K07082 - - - - ko00000 - - - YceG LANLAPFM_01365 622312.ROSEINA2194_01039 1.34e-123 355.0 COG4122@1|root,COG4122@2|Bacteria,1UF4M@1239|Firmicutes,24B70@186801|Clostridia 186801|Clostridia S O-methyltransferase yrrM - - - - - - - - - - - Methyltransf_3 LANLAPFM_01366 622312.ROSEINA2194_01040 9.89e-281 769.0 COG0826@1|root,COG0826@2|Bacteria,1TPRE@1239|Firmicutes,248I3@186801|Clostridia 186801|Clostridia O peptidase U32 yhbU_1 - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32,Peptidase_U32_C LANLAPFM_01367 585394.RHOM_05505 1.13e-207 579.0 COG2706@1|root,COG2706@2|Bacteria,1TQ3J@1239|Firmicutes,248JF@186801|Clostridia 186801|Clostridia G Psort location Cytoplasmic, score - - 3.1.1.31 ko:K07404 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Lactonase LANLAPFM_01368 585394.RHOM_05520 3.82e-115 346.0 COG0628@1|root,COG0628@2|Bacteria,1TS4S@1239|Firmicutes,248E5@186801|Clostridia 186801|Clostridia D Sporulation integral membrane protein YtvI ytvI - - - - - - - - - - - AI-2E_transport LANLAPFM_01369 622312.ROSEINA2194_03512 1.06e-236 659.0 COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248IH@186801|Clostridia 186801|Clostridia S ABC-type transport system, periplasmic component surface lipoprotein - - - ko:K07335 - - - - ko00000 - - - Bmp LANLAPFM_01370 622312.ROSEINA2194_03511 0.0 885.0 COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia 186801|Clostridia S Abc transporter - - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran LANLAPFM_01371 622312.ROSEINA2194_03510 1.68e-214 598.0 COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia 186801|Clostridia S Belongs to the binding-protein-dependent transport system permease family tsgB13 - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 LANLAPFM_01372 622312.ROSEINA2194_03509 1e-206 575.0 COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia 186801|Clostridia S Belongs to the binding-protein-dependent transport system permease family tsgC13 - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 LANLAPFM_01373 742765.HMPREF9457_00204 5.61e-143 410.0 COG0583@1|root,COG0583@2|Bacteria,1TRJK@1239|Firmicutes,24AY4@186801|Clostridia,27VZT@189330|Dorea 186801|Clostridia K Psort location Cytoplasmic, score 9.98 - - - - - - - - - - - - HTH_1,LysR_substrate LANLAPFM_01374 585394.RHOM_01170 7.12e-124 357.0 COG3619@1|root,COG3619@2|Bacteria,1V1VQ@1239|Firmicutes,24DUE@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF1275 LANLAPFM_01375 411461.DORFOR_01502 9.2e-115 336.0 28JZH@1|root,2Z9PI@2|Bacteria,1V0QF@1239|Firmicutes,248FG@186801|Clostridia,27WS8@189330|Dorea 186801|Clostridia S Domain of unknown function (DUF4866) - - - - - - - - - - - - DUF4866 LANLAPFM_01376 585394.RHOM_01185 1.79e-243 676.0 COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia 186801|Clostridia F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt LANLAPFM_01377 471875.RUMLAC_02383 1.14e-236 660.0 COG2966@1|root,COG3610@1|root,COG2966@2|Bacteria,COG3610@2|Bacteria,1TNZH@1239|Firmicutes,24BQZ@186801|Clostridia,3WHBW@541000|Ruminococcaceae 186801|Clostridia S Putative threonine/serine exporter - - - - - - - - - - - - ThrE,ThrE_2 LANLAPFM_01378 397287.C807_03866 1.37e-71 227.0 28S3E@1|root,2ZEF6@2|Bacteria,1V25C@1239|Firmicutes,24GTH@186801|Clostridia,27KYG@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01379 1034345.CAEM01000003_gene1256 7.26e-20 91.7 COG2199@1|root,COG3437@1|root,COG2199@2|Bacteria,COG3437@2|Bacteria,2I49F@201174|Actinobacteria,4CUE6@84998|Coriobacteriia 84998|Coriobacteriia T HD domain - - - ko:K07814 - - - - ko00000,ko02022 - - - GGDEF,HD,Response_reg LANLAPFM_01380 585394.RHOM_05525 2.3e-237 655.0 COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,248RC@186801|Clostridia 186801|Clostridia J Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b LANLAPFM_01381 585394.RHOM_09770 6.26e-110 319.0 COG0681@1|root,COG0681@2|Bacteria,1V2SF@1239|Firmicutes,24AWM@186801|Clostridia 186801|Clostridia U Belongs to the peptidase S26 family - - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 LANLAPFM_01382 622312.ROSEINA2194_00072 5.56e-170 478.0 COG1161@1|root,COG1161@2|Bacteria,1TQGK@1239|Firmicutes,2490H@186801|Clostridia 186801|Clostridia S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity ylqF - - ko:K14540 - - - - ko00000,ko03009 - - - MMR_HSR1 LANLAPFM_01383 1235790.C805_02231 3.65e-74 229.0 COG0681@1|root,COG0681@2|Bacteria,1UZ8V@1239|Firmicutes,25CN7@186801|Clostridia,25WUU@186806|Eubacteriaceae 186801|Clostridia U Signal peptidase, peptidase S26 - - - - - - - - - - - - Peptidase_S24 LANLAPFM_01384 585394.RHOM_09760 1.38e-134 386.0 COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,248IT@186801|Clostridia 186801|Clostridia L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII LANLAPFM_01385 585394.RHOM_09755 6.79e-198 578.0 28J8T@1|root,2Z93Y@2|Bacteria,1UZBP@1239|Firmicutes,24F5R@186801|Clostridia 186801|Clostridia S Flagellar hook-length control protein FliK - - - - - - - - - - - - Flg_hook LANLAPFM_01386 585394.RHOM_09750 5.68e-49 157.0 COG2257@1|root,COG2257@2|Bacteria,1VF4R@1239|Firmicutes,24QSW@186801|Clostridia 186801|Clostridia S cytoplasmic domain of flagellar protein FhlB flhB1 - - ko:K04061 - - - - ko00000,ko02044 - - - Bac_export_2 LANLAPFM_01387 622312.ROSEINA2194_00076 5.96e-56 176.0 COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia 186801|Clostridia L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 LANLAPFM_01388 622312.ROSEINA2194_00077 4.42e-145 416.0 COG1496@1|root,COG1496@2|Bacteria,1TS34@1239|Firmicutes,248TD@186801|Clostridia 186801|Clostridia L Belongs to the multicopper oxidase YfiH RL5 family yfiH - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 LANLAPFM_01389 622312.ROSEINA2194_01455 6.58e-131 385.0 2DCHY@1|root,2ZE7V@2|Bacteria,1UMSB@1239|Firmicutes,25FCG@186801|Clostridia 186801|Clostridia - - - - 5.2.1.8 ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2 LANLAPFM_01390 585394.RHOM_13135 0.0 1947.0 COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia 186801|Clostridia L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF LANLAPFM_01391 622312.ROSEINA2194_01453 3.06e-113 327.0 COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,24HMC@186801|Clostridia 186801|Clostridia J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro LANLAPFM_01392 585394.RHOM_13145 1.18e-144 411.0 COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,248Z3@186801|Clostridia 186801|Clostridia M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase LANLAPFM_01393 585394.RHOM_14095 9.57e-71 229.0 COG0840@1|root,COG0840@2|Bacteria,1TY0J@1239|Firmicutes,24DGH@186801|Clostridia 186801|Clostridia NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal LANLAPFM_01394 585394.RHOM_14090 1.42e-179 508.0 COG3287@1|root,COG3287@2|Bacteria,1UK57@1239|Firmicutes,24D5K@186801|Clostridia 186801|Clostridia S FIST N domain - - - - - - - - - - - - FIST,FIST_C LANLAPFM_01395 585394.RHOM_07975 1.03e-68 210.0 COG0295@1|root,COG0295@2|Bacteria,1V6IP@1239|Firmicutes,24JEM@186801|Clostridia 186801|Clostridia F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis cdd - 3.5.4.5 ko:K01489 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko01000 - - - dCMP_cyt_deam_1,dCMP_cyt_deam_2 LANLAPFM_01396 622312.ROSEINA2194_03850 2.83e-287 789.0 COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,24865@186801|Clostridia 186801|Clostridia C citrate synthase - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt LANLAPFM_01397 585394.RHOM_07985 1.93e-233 659.0 COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA LANLAPFM_01398 585394.RHOM_07990 6.67e-141 400.0 COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,2484X@186801|Clostridia 186801|Clostridia T response regulator receiver - - - ko:K07775 ko02020,map02020 M00458 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C LANLAPFM_01399 1469948.JPNB01000002_gene3304 9.14e-22 88.2 COG1396@1|root,COG1396@2|Bacteria,1VAEQ@1239|Firmicutes,24RMB@186801|Clostridia 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 LANLAPFM_01400 585394.RHOM_12475 0.0 1766.0 COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia 186801|Clostridia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran LANLAPFM_01401 585394.RHOM_12480 0.0 1223.0 COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia 186801|Clostridia L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB LANLAPFM_01402 585394.RHOM_12610 1.35e-251 694.0 COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia 186801|Clostridia C domain protein norV - - - - - - - - - - - Flavodoxin_1,Flavodoxin_5,Lactamase_B,Lactamase_B_2 LANLAPFM_01403 585394.RHOM_12615 0.0 1536.0 COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia 186801|Clostridia U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW LANLAPFM_01404 585394.RHOM_12620 2.17e-52 165.0 2E3FD@1|root,32YE7@2|Bacteria,1VEE4@1239|Firmicutes,24QJ7@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - TSCPD LANLAPFM_01405 585394.RHOM_12625 3.7e-123 352.0 COG0452@1|root,COG0452@2|Bacteria,1TQPT@1239|Firmicutes,24HE6@186801|Clostridia 186801|Clostridia H Dipicolinic acid synthetase, b subunit spoVFB - - ko:K06411 - - - - ko00000 - - - Flavoprotein LANLAPFM_01406 585394.RHOM_12630 1.52e-145 416.0 COG0169@1|root,COG0169@2|Bacteria,1UHR5@1239|Firmicutes,25ETW@186801|Clostridia 186801|Clostridia E dipicolinic acid synthetase, A subunit - - - ko:K06410 - - - - ko00000 - - - 2-Hacid_dh_C,AdoHcyase_NAD,DpaA_N,IlvN LANLAPFM_01407 622312.ROSEINA2194_03033 3.55e-296 810.0 COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,24811@186801|Clostridia 186801|Clostridia E Belongs to the aspartokinase family thrA - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 LANLAPFM_01408 585394.RHOM_12645 8.79e-136 390.0 COG2908@1|root,COG2908@2|Bacteria,1TT6N@1239|Firmicutes,24A8X@186801|Clostridia 186801|Clostridia S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos,Metallophos_2 LANLAPFM_01409 585394.RHOM_12650 7.89e-92 282.0 2C69W@1|root,2Z7HR@2|Bacteria,1TQNN@1239|Firmicutes,249G5@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF4474) - - - - - - - - - - - - DUF4474 LANLAPFM_01410 411470.RUMGNA_01046 2.54e-301 832.0 COG0246@1|root,COG0246@2|Bacteria,1TQ97@1239|Firmicutes,247TG@186801|Clostridia,3XYQY@572511|Blautia 186801|Clostridia G Mannitol dehydrogenase Rossmann domain - - 1.1.1.57 ko:K00040 ko00040,ko01100,map00040,map01100 M00061 R02454 RC00085 ko00000,ko00001,ko00002,ko01000 - - - Mannitol_dh,Mannitol_dh_C LANLAPFM_01411 658655.HMPREF0988_01291 3.86e-130 378.0 COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,1TPMG@1239|Firmicutes,25E9N@186801|Clostridia,27UHQ@186928|unclassified Lachnospiraceae 186801|Clostridia K Cupin domain - - - - - - - - - - - - ARD,AraC_binding,Cupin_2,HTH_18 LANLAPFM_01412 658088.HMPREF0987_02461 1.17e-167 472.0 COG1402@1|root,COG1402@2|Bacteria,1UDUM@1239|Firmicutes,2494R@186801|Clostridia 186801|Clostridia S Creatinine amidohydrolase - - - - - - - - - - - - Creatininase LANLAPFM_01413 658088.HMPREF0987_02460 7.06e-128 372.0 COG2159@1|root,COG2159@2|Bacteria 2|Bacteria E amidohydrolase - - - - - - - - - - - - Amidohydro_2 LANLAPFM_01414 658088.HMPREF0987_02459 1.5e-266 737.0 COG2211@1|root,COG2211@2|Bacteria,1TRYR@1239|Firmicutes,25C8G@186801|Clostridia,27KBK@186928|unclassified Lachnospiraceae 186801|Clostridia G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 LANLAPFM_01415 658088.HMPREF0987_02458 3.05e-108 325.0 COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,1TPMG@1239|Firmicutes,24ISI@186801|Clostridia,27T9S@186928|unclassified Lachnospiraceae 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18 LANLAPFM_01416 877415.JNJQ01000002_gene2280 5.35e-231 639.0 COG1312@1|root,COG1312@2|Bacteria,1TP5F@1239|Firmicutes,3VPNW@526524|Erysipelotrichia 526524|Erysipelotrichia G Catalyzes the dehydration of D-mannonate uxuA - - - - - - - - - - - UxuA LANLAPFM_01417 585394.RHOM_12655 1.59e-108 323.0 COG1388@1|root,COG1388@2|Bacteria,1V4FC@1239|Firmicutes 1239|Firmicutes M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - - - - - - - - - - LysM LANLAPFM_01418 585394.RHOM_12660 3.95e-124 358.0 COG1346@1|root,COG1346@2|Bacteria,1TRGN@1239|Firmicutes,24AGM@186801|Clostridia 186801|Clostridia M Psort location CytoplasmicMembrane, score lrgB - - - - - - - - - - - LrgB LANLAPFM_01419 585394.RHOM_12665 9.56e-51 163.0 COG1380@1|root,COG1380@2|Bacteria,1VEN4@1239|Firmicutes,24MMB@186801|Clostridia 186801|Clostridia S LrgA family lrgA - - ko:K06518 - - - - ko00000,ko02000 1.E.14.2 - - LrgA LANLAPFM_01420 622312.ROSEINA2194_03041 4.35e-192 548.0 COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,1TR1R@1239|Firmicutes,24A67@186801|Clostridia 186801|Clostridia CE FAD dependent oxidoreductase - - - - - - - - - - - - DAO,Rieske LANLAPFM_01421 585394.RHOM_12675 4.33e-85 258.0 COG0727@1|root,COG0727@2|Bacteria,1TT6P@1239|Firmicutes,24BWS@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC LANLAPFM_01422 1235800.C819_03424 4.59e-172 492.0 COG0657@1|root,COG0657@2|Bacteria,1VUQV@1239|Firmicutes,250IT@186801|Clostridia,27UKJ@186928|unclassified Lachnospiraceae 186801|Clostridia I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3 LANLAPFM_01423 1226325.HMPREF1548_02199 1.71e-24 97.4 COG4942@1|root,COG4942@2|Bacteria,1VSWX@1239|Firmicutes 1239|Firmicutes D K03657 DNA helicase II ATP-dependent DNA helicase PcrA - - - - - - - - - - - - - LANLAPFM_01424 658086.HMPREF0994_01172 7.88e-21 89.0 COG4942@1|root,COG4942@2|Bacteria,1V67C@1239|Firmicutes,25FCI@186801|Clostridia 186801|Clostridia D Psort location Cytoplasmic, score - - - - - - - - - - - - PDDEXK_2 LANLAPFM_01425 585394.RHOM_11485 0.0 1046.0 COG1109@1|root,COG1109@2|Bacteria,1TP2N@1239|Firmicutes,2481Y@186801|Clostridia 186801|Clostridia G phosphoglucomutase phosphomannomutase alpha beta alpha domain II - - 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV LANLAPFM_01426 397291.C804_03204 0.0 1088.0 COG3345@1|root,COG3345@2|Bacteria,1TQF4@1239|Firmicutes,2489F@186801|Clostridia,27I65@186928|unclassified Lachnospiraceae 186801|Clostridia G Glycosyl hydrolase family 36 N-terminal domain - - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Glyco_hydro_36C,Glyco_hydro_36N,Melibiase LANLAPFM_01427 585394.RHOM_11475 7.94e-149 429.0 COG1609@1|root,COG1609@2|Bacteria,1TT55@1239|Firmicutes,24A7X@186801|Clostridia 186801|Clostridia K Periplasmic binding protein LacI transcriptional regulator - - - ko:K02529,ko:K03604 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 LANLAPFM_01428 585394.RHOM_08210 0.0 872.0 COG0246@1|root,COG0246@2|Bacteria,1TPZU@1239|Firmicutes,248J5@186801|Clostridia 186801|Clostridia G Mannitol dehydrogenase - - 1.1.1.58 ko:K00041 ko00040,ko01100,map00040,map01100 M00631 R02555 RC00085 ko00000,ko00001,ko00002,ko01000 - - - Mannitol_dh,Mannitol_dh_C LANLAPFM_01429 585394.RHOM_08205 2.51e-305 838.0 COG2721@1|root,COG2721@2|Bacteria,1TPTX@1239|Firmicutes,24AEC@186801|Clostridia 186801|Clostridia G D-galactarate dehydratase Altronate hydrolase uxaA - 4.2.1.7 ko:K01685 ko00040,ko01100,map00040,map01100 M00631 R01540 RC00543 ko00000,ko00001,ko00002,ko01000 - - - GD_AH_C,SAF LANLAPFM_01430 585394.RHOM_04075 9.67e-177 494.0 COG1028@1|root,COG1028@2|Bacteria,1TPZ8@1239|Firmicutes,24903@186801|Clostridia 186801|Clostridia IQ PFAM Short-chain dehydrogenase reductase SDR - - 1.1.1.69 ko:K00046 - - - - ko00000,ko01000 - - - adh_short_C2 LANLAPFM_01431 1235793.C809_01107 4.63e-203 578.0 COG1680@1|root,COG1680@2|Bacteria,1TSXS@1239|Firmicutes,24H20@186801|Clostridia 186801|Clostridia V Beta-lactamase - - - - - - - - - - - - Beta-lactamase LANLAPFM_01432 1055815.AYYA01000008_gene2221 3.65e-08 55.5 COG2207@1|root,COG2207@2|Bacteria,1MUEM@1224|Proteobacteria,1T1VS@1236|Gammaproteobacteria,3NTMP@468|Moraxellaceae 1236|Gammaproteobacteria K AraC-type transcriptional regulator N-terminus - - - - - - - - - - - - AraC_N,HTH_18 LANLAPFM_01433 585394.RHOM_08550 0.0 867.0 COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia 186801|Clostridia E amino acid carrier protein agcS - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp LANLAPFM_01434 622312.ROSEINA2194_01354 2.74e-241 663.0 2C4R5@1|root,2Z7JK@2|Bacteria,1TQIE@1239|Firmicutes,24879@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - GGGtGRT LANLAPFM_01435 585394.RHOM_08560 1.39e-165 462.0 COG0822@1|root,COG0822@2|Bacteria,1TQEQ@1239|Firmicutes,248ID@186801|Clostridia 186801|Clostridia C Psort location Cytoplasmic, score - - - - - - - - - - - - NifU_N LANLAPFM_01436 585394.RHOM_08565 1.73e-115 356.0 COG1033@1|root,COG1033@2|Bacteria,1VIN4@1239|Firmicutes 1239|Firmicutes S YARHG - - - - - - - - - - - - YARHG LANLAPFM_01437 1280664.AUIX01000017_gene2031 2.56e-140 406.0 COG0826@1|root,COG0826@2|Bacteria,1TRX5@1239|Firmicutes,24FI8@186801|Clostridia,4BW71@830|Butyrivibrio 186801|Clostridia O Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_01438 935837.JAEK01000032_gene2591 0.0 1100.0 COG3250@1|root,COG3250@2|Bacteria,1TPK7@1239|Firmicutes,4HBHM@91061|Bacilli,1ZPWQ@1386|Bacillus 91061|Bacilli G Domain of unknown function (DUF4982) bgaA - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Big_4,DUF4982,G5,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Gram_pos_anchor,YSIRK_signal LANLAPFM_01439 585394.RHOM_16615 4.91e-301 823.0 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia 186801|Clostridia L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C LANLAPFM_01440 585394.RHOM_16620 8.36e-76 228.0 COG0359@1|root,COG0359@2|Bacteria,1V6QG@1239|Firmicutes,24MT6@186801|Clostridia 186801|Clostridia J Binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N LANLAPFM_01441 1280676.AUJO01000002_gene1479 1.94e-124 360.0 COG0395@1|root,COG0395@2|Bacteria,1TP1G@1239|Firmicutes,247T2@186801|Clostridia,4C1Y7@830|Butyrivibrio 186801|Clostridia G PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K17320 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 LANLAPFM_01442 1280676.AUJO01000002_gene1478 5.44e-257 716.0 COG1653@1|root,COG1653@2|Bacteria,1TPWV@1239|Firmicutes,24AWQ@186801|Clostridia,4BYV9@830|Butyrivibrio 186801|Clostridia G Domain of unknown function (DUF3502) - - - ko:K17318 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - DUF3502,SBP_bac_1,SBP_bac_8 LANLAPFM_01443 397291.C804_02928 2.22e-217 602.0 COG2152@1|root,COG2152@2|Bacteria,1TQE7@1239|Firmicutes,249D0@186801|Clostridia,27JZU@186928|unclassified Lachnospiraceae 186801|Clostridia G beta-1,4-mannooligosaccharide phosphorylase - - 2.4.1.319,2.4.1.320 ko:K18785 - - R10811,R10829 RC00049 ko00000,ko01000 - - - Glyco_hydro_130 LANLAPFM_01444 457412.RSAG_02071 0.0 936.0 COG1874@1|root,COG1874@2|Bacteria,1UZRC@1239|Firmicutes,24EDS@186801|Clostridia 186801|Clostridia G Beta-galactosidase - - - - - - - - - - - - - LANLAPFM_01445 658086.HMPREF0994_01029 5.86e-246 709.0 28I74@1|root,2Z8A0@2|Bacteria,1VR23@1239|Firmicutes 1239|Firmicutes S COG NOG26804 non supervised orthologous group - - - - - - - - - - - - - LANLAPFM_01446 397291.C804_02929 0.0 1614.0 COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,248VH@186801|Clostridia,27KWU@186928|unclassified Lachnospiraceae 186801|Clostridia G Alpha mannosidase, middle domain - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C LANLAPFM_01447 1128421.JAGA01000003_gene2954 5.02e-31 131.0 COG2211@1|root,COG2211@2|Bacteria,2NR8E@2323|unclassified Bacteria 2|Bacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 LANLAPFM_01448 1195236.CTER_1937 2.35e-263 753.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia 186801|Clostridia G hydrolase, family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C LANLAPFM_01449 658086.HMPREF0994_03950 3.18e-209 605.0 COG3525@1|root,COG3525@2|Bacteria,1TSXM@1239|Firmicutes,248U1@186801|Clostridia,27QES@186928|unclassified Lachnospiraceae 186801|Clostridia G Glycosyl hydrolase family 20, domain 2 - - - - - - - - - - - - F5_F8_type_C,Glyco_hydro_20,Glyco_hydro_20b LANLAPFM_01450 622312.ROSEINA2194_03990 2.21e-102 299.0 COG2002@1|root,COG2002@2|Bacteria,1V02A@1239|Firmicutes,248XR@186801|Clostridia 186801|Clostridia K stage V sporulation protein T spoVT - - ko:K04769 - - - - ko00000,ko03000 - - - MazE_antitoxin,SpoVT_C LANLAPFM_01451 622312.ROSEINA2194_03989 4.08e-168 479.0 COG0420@1|root,COG0420@2|Bacteria,1TWMI@1239|Firmicutes,24BN3@186801|Clostridia 186801|Clostridia L Ser Thr phosphatase family protein - - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos,Metallophos_2 LANLAPFM_01452 622312.ROSEINA2194_03988 5.92e-138 418.0 COG4717@1|root,COG4717@2|Bacteria,1TQP3@1239|Firmicutes,24E0A@186801|Clostridia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - AAA_23,AAA_27 LANLAPFM_01453 622312.ROSEINA2194_03986 0.0 962.0 COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,248A4@186801|Clostridia 186801|Clostridia M penicillin-binding protein 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase LANLAPFM_01454 622312.ROSEINA2194_03984 7.51e-195 543.0 COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia 186801|Clostridia GK ROK family - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK LANLAPFM_01455 585394.RHOM_14100 1.57e-124 358.0 COG3859@1|root,COG3859@2|Bacteria,1V1WX@1239|Firmicutes,24E4Z@186801|Clostridia 186801|Clostridia S Proton-coupled thiamine transporter YuaJ yuaJ - - ko:K16789 - - - - ko00000,ko02000 2.A.88.3 - - Thia_YuaJ LANLAPFM_01456 397291.C804_05932 1.42e-129 382.0 COG0614@1|root,COG0614@2|Bacteria,1UIJ9@1239|Firmicutes,25BH2@186801|Clostridia 186801|Clostridia P Periplasmic binding protein - - - - - - - - - - - - Peripla_BP_2 LANLAPFM_01457 397291.C804_04092 1.78e-163 476.0 COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1TQNH@1239|Firmicutes,2487I@186801|Clostridia,27TN6@186928|unclassified Lachnospiraceae 186801|Clostridia H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps cobA - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 ko:K02302,ko:K02303,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03165,R03194,R03947 RC00003,RC00871,RC01012,RC01034,RC01861 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS15755 HEM4,Porphobil_deam,Porphobil_deamC,TP_methylase LANLAPFM_01458 585394.RHOM_14885 6.18e-37 130.0 COG1669@1|root,COG1669@2|Bacteria,1VBYU@1239|Firmicutes,24N0Y@186801|Clostridia 186801|Clostridia S TIGRFAM nucleotidyltransferase substrate binding protein, HI0074 family - - - - - - - - - - - - NTP_transf_2,NTase_sub_bind LANLAPFM_01459 1469948.JPNB01000001_gene1957 1.58e-57 183.0 COG0386@1|root,COG0386@2|Bacteria,1V3M3@1239|Firmicutes,24HGF@186801|Clostridia,36IXW@31979|Clostridiaceae 186801|Clostridia O Belongs to the glutathione peroxidase family - - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx LANLAPFM_01460 397291.C804_05931 1.38e-113 334.0 COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,27MTD@186928|unclassified Lachnospiraceae 186801|Clostridia HP ATPases associated with a variety of cellular activities - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran LANLAPFM_01461 397291.C804_05930 2.46e-142 412.0 COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,24BGM@186801|Clostridia,27U55@186928|unclassified Lachnospiraceae 186801|Clostridia P FecCD transport family - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD LANLAPFM_01462 585394.RHOM_00400 0.0 902.0 COG1283@1|root,COG1283@2|Bacteria,1TP4K@1239|Firmicutes,247KT@186801|Clostridia 186801|Clostridia P Na Pi-cotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU LANLAPFM_01463 622312.ROSEINA2194_04402 8.01e-127 365.0 COG0745@1|root,COG0745@2|Bacteria,1TQY9@1239|Firmicutes,24D6A@186801|Clostridia 186801|Clostridia T Response regulator receiver domain protein phoB - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C LANLAPFM_01464 585394.RHOM_00410 5.25e-216 607.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia 186801|Clostridia T Histidine kinase phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,sCache_like LANLAPFM_01465 585394.RHOM_00425 0.0 1631.0 COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia 186801|Clostridia L snf2 family - - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - Helicase_C,SNF2_N,SNF2_assoc,SWIM LANLAPFM_01466 585394.RHOM_00435 2.06e-103 302.0 COG1971@1|root,COG1971@2|Bacteria,1V4QK@1239|Firmicutes,24FY0@186801|Clostridia 186801|Clostridia P Probably functions as a manganese efflux pump mntP - - - - - - - - - - - Mntp LANLAPFM_01467 585394.RHOM_00440 4.6e-150 431.0 COG0530@1|root,COG0530@2|Bacteria,1TRX0@1239|Firmicutes,24ABZ@186801|Clostridia 186801|Clostridia P K -dependent Na Ca exchanger family protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex LANLAPFM_01468 585394.RHOM_00445 1.52e-50 163.0 2DPVJ@1|root,333JK@2|Bacteria,1VGI4@1239|Firmicutes,24R70@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - DZR,zinc_ribbon_2 LANLAPFM_01469 585394.RHOM_00450 2e-159 466.0 2A7KX@1|root,30WIW@2|Bacteria,1V536@1239|Firmicutes,24J38@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01470 622312.ROSEINA2194_01741 1.28e-103 304.0 COG2755@1|root,COG2755@2|Bacteria,1V3A9@1239|Firmicutes,24FYQ@186801|Clostridia 186801|Clostridia E COG2755 Lysophospholipase L1 and related esterases - - - - - - - - - - - - Lipase_GDSL_2 LANLAPFM_01472 1280698.AUJS01000028_gene2292 8.95e-102 298.0 COG1954@1|root,COG1954@2|Bacteria,1V4IE@1239|Firmicutes,24HDM@186801|Clostridia,27VYY@189330|Dorea 186801|Clostridia K Glycerol-3-phosphate responsive antiterminator glpP - - ko:K02443 - - - - ko00000,ko03000 - - - G3P_antiterm LANLAPFM_01473 411462.DORLON_02611 0.0 989.0 COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,27V84@189330|Dorea 186801|Clostridia F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N LANLAPFM_01474 411462.DORLON_02610 3.47e-153 432.0 COG0580@1|root,COG0580@2|Bacteria,1TP4T@1239|Firmicutes,248U5@186801|Clostridia 186801|Clostridia G Belongs to the MIP aquaporin (TC 1.A.8) family glpF - - ko:K02440 - - - - ko00000,ko02000 1.A.8.1,1.A.8.2 - - MIP LANLAPFM_01475 411462.DORLON_02609 2.29e-298 819.0 COG0579@1|root,COG0579@2|Bacteria,1TRDH@1239|Firmicutes,248IK@186801|Clostridia,27V95@189330|Dorea 186801|Clostridia S BFD-like [2Fe-2S] binding domain - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,Fer2_BFD LANLAPFM_01476 411462.DORLON_02608 2.74e-275 756.0 COG0446@1|root,COG0446@2|Bacteria,1TQH5@1239|Firmicutes,247YR@186801|Clostridia,27UZQ@189330|Dorea 186801|Clostridia C FAD dependent oxidoreductase - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_3 LANLAPFM_01477 411462.DORLON_02607 2.19e-64 198.0 COG3862@1|root,COG3862@2|Bacteria,1VA4U@1239|Firmicutes,24MN9@186801|Clostridia,27VRH@189330|Dorea 186801|Clostridia S Protein of unknown function (DUF1667) - - - - - - - - - - - - DUF1667 LANLAPFM_01478 1340434.AXVA01000004_gene2641 2.79e-06 58.5 COG1653@1|root,COG3757@1|root,COG4733@1|root,COG1653@2|Bacteria,COG3757@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity lyc GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.2.1.17,3.2.1.8 ko:K01181,ko:K01185,ko:K02027,ko:K07273,ko:K07451,ko:K17315,ko:K17318 ko02010,map02010 M00207,M00603,M00605 - - ko00000,ko00001,ko00002,ko01000,ko02000,ko02048 3.A.1.1,3.A.1.1.24,3.A.1.1.29,3.A.1.1.30,3.A.1.1.9 - - Glyco_hydro_25,LysM,Phage-tail_3 LANLAPFM_01480 585394.RHOM_00480 0.0 1203.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,248AU@186801|Clostridia 186801|Clostridia J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind LANLAPFM_01481 585394.RHOM_00485 1.04e-123 374.0 2A7KX@1|root,30WIW@2|Bacteria,1V536@1239|Firmicutes,24J38@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01482 585394.RHOM_00490 3.32e-38 143.0 2ANQY@1|root,31DQM@2|Bacteria,1V7FM@1239|Firmicutes,24MF6@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01483 1235800.C819_00145 2.89e-07 58.9 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,27IZH@186928|unclassified Lachnospiraceae 186801|Clostridia NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,dCache_1 LANLAPFM_01485 622312.ROSEINA2194_00904 1.84e-149 424.0 COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia 186801|Clostridia L hydrolase, TatD family ycfH - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase LANLAPFM_01486 622312.ROSEINA2194_00905 2.22e-118 347.0 2DBGV@1|root,2Z969@2|Bacteria,1UI0Y@1239|Firmicutes,25E9X@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF4130 LANLAPFM_01487 622312.ROSEINA2194_00906 8.26e-275 757.0 COG4277@1|root,COG4277@2|Bacteria,1TRT2@1239|Firmicutes,247UD@186801|Clostridia 186801|Clostridia S DNA modification repair radical SAM protein - - - - - - - - - - - - HHH_3,Radical_SAM LANLAPFM_01488 742765.HMPREF9457_03255 7.21e-145 421.0 COG2070@1|root,COG2070@2|Bacteria,1TPX1@1239|Firmicutes,247YZ@186801|Clostridia,27V3C@189330|Dorea 186801|Clostridia S Nitronate monooxygenase - - - - - - - - - - - - NMO LANLAPFM_01489 622312.ROSEINA2194_03681 2.31e-234 645.0 COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,247M9@186801|Clostridia 186801|Clostridia M Belongs to the NAD(P)-dependent epimerase dehydratase family galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd LANLAPFM_01490 585394.RHOM_08530 1.45e-172 484.0 COG2207@1|root,COG2207@2|Bacteria,1UZ0Q@1239|Firmicutes,24YIV@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - AraC_binding,HTH_18 LANLAPFM_01491 585394.RHOM_08535 7.79e-127 365.0 COG0613@1|root,COG0613@2|Bacteria,1V33M@1239|Firmicutes,24H1U@186801|Clostridia 186801|Clostridia S PHP domain protein - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP,PHP_C LANLAPFM_01492 622312.ROSEINA2194_01009 1.33e-70 213.0 COG0292@1|root,COG0292@2|Bacteria,1V6DB@1239|Firmicutes,24JBJ@186801|Clostridia 186801|Clostridia J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT - - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 LANLAPFM_01493 585394.RHOM_08100 2.92e-34 117.0 COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,24QJD@186801|Clostridia 186801|Clostridia J Belongs to the bacterial ribosomal protein bL35 family rpmI - - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p LANLAPFM_01494 585394.RHOM_08105 1.78e-102 298.0 COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,24FUS@186801|Clostridia 186801|Clostridia J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N LANLAPFM_01495 397288.C806_03378 9.13e-159 472.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,27KAK@186928|unclassified Lachnospiraceae 186801|Clostridia NT Four helix bundle sensory module for signal transduction - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,MCPsignal,dCache_1 LANLAPFM_01496 622312.ROSEINA2194_02490 2.27e-58 185.0 COG0835@1|root,COG0835@2|Bacteria 2|Bacteria NT chemotaxis - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW LANLAPFM_01497 585394.RHOM_08120 8.1e-144 412.0 COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia 186801|Clostridia S PHP domain - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP LANLAPFM_01498 585394.RHOM_08125 2.7e-130 377.0 COG0561@1|root,COG0561@2|Bacteria,1TREF@1239|Firmicutes,24PNN@186801|Clostridia 186801|Clostridia S HAD-superfamily hydrolase, subfamily IIB yidA - - - - - - - - - - - Hydrolase_3 LANLAPFM_01499 585394.RHOM_08130 0.0 1185.0 COG0855@1|root,COG0855@2|Bacteria,1TNZM@1239|Firmicutes,248XY@186801|Clostridia 186801|Clostridia P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N LANLAPFM_01500 622312.ROSEINA2194_01001 2.86e-278 771.0 COG0248@1|root,COG0248@2|Bacteria,1TS3I@1239|Firmicutes,248EW@186801|Clostridia 186801|Clostridia FP Ppx GppA phosphatase ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - HD,Ppx-GppA LANLAPFM_01501 585394.RHOM_08140 1.04e-263 728.0 COG2607@1|root,COG2607@2|Bacteria,1TQDJ@1239|Firmicutes,2483S@186801|Clostridia 186801|Clostridia E ATPase (AAA superfamily) - - - ko:K06923 - - - - ko00000 - - - DUF815 LANLAPFM_01502 585394.RHOM_08145 4.78e-217 605.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1TPDN@1239|Firmicutes,248G7@186801|Clostridia 186801|Clostridia E Prephenate dehydratase pheA - 4.2.1.51,5.4.99.5 ko:K04518,ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT LANLAPFM_01503 622312.ROSEINA2194_00998 4.03e-103 313.0 COG0823@1|root,COG0823@2|Bacteria,1V60E@1239|Firmicutes,24I0N@186801|Clostridia 186801|Clostridia U Domain of unknown function (DUF5050) - - - - - - - - - - - - DUF5050 LANLAPFM_01504 622312.ROSEINA2194_00997 0.0 2601.0 COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia 186801|Clostridia L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity polC - 2.7.7.7 ko:K03763 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon LANLAPFM_01505 585394.RHOM_07195 9.54e-226 625.0 COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia 186801|Clostridia I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS06430 GcpE LANLAPFM_01506 622312.ROSEINA2194_00995 5.71e-190 534.0 COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,247MT@186801|Clostridia 186801|Clostridia M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 LANLAPFM_01507 585394.RHOM_07185 3.87e-207 580.0 COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,2483M@186801|Clostridia 186801|Clostridia I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS06420 DXPR_C,DXP_redisom_C,DXP_reductoisom LANLAPFM_01508 622312.ROSEINA2194_00993 1.79e-148 422.0 COG0575@1|root,COG0575@2|Bacteria,1UPNB@1239|Firmicutes,248BP@186801|Clostridia 186801|Clostridia I Belongs to the CDS family cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 LANLAPFM_01509 622312.ROSEINA2194_00992 3.33e-145 413.0 COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia 186801|Clostridia H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf LANLAPFM_01510 622312.ROSEINA2194_00991 3.3e-107 311.0 COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,24HWS@186801|Clostridia 186801|Clostridia J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF LANLAPFM_01511 585394.RHOM_07165 2.35e-151 427.0 COG0528@1|root,COG0528@2|Bacteria,1TPXN@1239|Firmicutes,247KR@186801|Clostridia 186801|Clostridia F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase LANLAPFM_01512 622312.ROSEINA2194_00989 2.85e-77 243.0 COG1664@1|root,COG1664@2|Bacteria,1TS93@1239|Firmicutes,24DZX@186801|Clostridia 186801|Clostridia M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin LANLAPFM_01513 622312.ROSEINA2194_00988 2.43e-148 427.0 COG0726@1|root,COG0726@2|Bacteria,1V1X7@1239|Firmicutes,25B6U@186801|Clostridia 186801|Clostridia G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 LANLAPFM_01514 585394.RHOM_05225 1.09e-170 486.0 COG0630@1|root,COG0630@2|Bacteria,1UHT2@1239|Firmicutes,25EN1@186801|Clostridia 186801|Clostridia NU COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis - - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE LANLAPFM_01519 585394.RHOM_07695 1.83e-147 421.0 COG1792@1|root,COG1792@2|Bacteria,1TR1V@1239|Firmicutes,249M3@186801|Clostridia 186801|Clostridia M Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC LANLAPFM_01520 585394.RHOM_07700 4.99e-213 592.0 COG1077@1|root,COG1077@2|Bacteria,1TPVU@1239|Firmicutes,248CM@186801|Clostridia 186801|Clostridia D Cell shape determining protein, MreB Mrl family - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl LANLAPFM_01521 585394.RHOM_07705 2.19e-91 275.0 COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,2498Z@186801|Clostridia 186801|Clostridia E Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC LANLAPFM_01523 585394.RHOM_07710 5.91e-282 774.0 COG4100@1|root,COG4100@2|Bacteria,1TQ88@1239|Firmicutes,247Y4@186801|Clostridia 186801|Clostridia P aluminum resistance protein ynbB - - - - - - - - - - - Met_gamma_lyase LANLAPFM_01524 622312.ROSEINA2194_03770 1.95e-179 505.0 COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,248HB@186801|Clostridia 186801|Clostridia J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT LANLAPFM_01525 622312.ROSEINA2194_03771 0.0 909.0 COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia 186801|Clostridia L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C LANLAPFM_01526 1235802.C823_03200 1.45e-100 298.0 COG1351@1|root,COG1351@2|Bacteria,1TRAA@1239|Firmicutes,249DJ@186801|Clostridia,25V4I@186806|Eubacteriaceae 186801|Clostridia F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 LANLAPFM_01527 585394.RHOM_07725 0.0 1498.0 COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia 186801|Clostridia L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V LANLAPFM_01528 585394.RHOM_07730 6.99e-253 709.0 COG2509@1|root,COG2509@2|Bacteria,1TPBW@1239|Firmicutes,247TR@186801|Clostridia 186801|Clostridia H 'oxidoreductase - - - ko:K07137 - - - - ko00000 - - - HI0933_like,NAD_binding_8,Pyr_redox_2 LANLAPFM_01529 622312.ROSEINA2194_03775 6.64e-175 502.0 COG2081@1|root,COG2081@2|Bacteria,1TR7U@1239|Firmicutes,2497W@186801|Clostridia 186801|Clostridia S Flavoprotein family - - - ko:K07007 - - - - ko00000 - - - HI0933_like LANLAPFM_01531 585394.RHOM_07745 9.6e-261 730.0 COG2244@1|root,COG2244@2|Bacteria,1TNYX@1239|Firmicutes,2485G@186801|Clostridia 186801|Clostridia S Stage V sporulation protein B spoVB1 - - ko:K06409 - - - - ko00000,ko02000 2.A.66.2.14 - - Polysacc_synt,Polysacc_synt_C LANLAPFM_01532 622312.ROSEINA2194_03780 1.08e-87 260.0 COG0319@1|root,COG0319@2|Bacteria,1V6BU@1239|Firmicutes,24MQZ@186801|Clostridia 186801|Clostridia F Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - 3.5.4.5 ko:K01489,ko:K07042 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko01000,ko03009 - - - UPF0054 LANLAPFM_01533 585394.RHOM_07755 2.71e-109 333.0 COG1480@1|root,COG1480@2|Bacteria 2|Bacteria O 7TM receptor with intracellular HD hydrolase - - - ko:K07037 - - - - ko00000 - - - - LANLAPFM_01534 585394.RHOM_07760 3.5e-207 577.0 COG1702@1|root,COG1702@2|Bacteria,1TP35@1239|Firmicutes,247ZJ@186801|Clostridia 186801|Clostridia T phosphate starvation-inducible protein phoH - - ko:K06217 - - - - ko00000 - - - PhoH LANLAPFM_01535 585394.RHOM_07765 4.06e-161 466.0 COG0561@1|root,COG0561@2|Bacteria,1TR3N@1239|Firmicutes,24ACD@186801|Clostridia 186801|Clostridia S Sporulation protein YqfD yqfD - - ko:K06438 - - - - ko00000 - - - YqfD LANLAPFM_01536 1235790.C805_01829 1.94e-29 107.0 2B2ZJ@1|root,31VKQ@2|Bacteria,1TVEP@1239|Firmicutes,25NEX@186801|Clostridia,25XCH@186806|Eubacteriaceae 186801|Clostridia S YabP family - - - - - - - - - - - - YabP LANLAPFM_01537 585394.RHOM_07775 7.43e-234 652.0 COG0213@1|root,COG0213@2|Bacteria,1TPCH@1239|Firmicutes,24848@186801|Clostridia 186801|Clostridia F pyrimidine-nucleoside phosphorylase pdp - 2.4.2.2,2.4.2.4 ko:K00756,ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R01876,R02296,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS08925 Glycos_trans_3N,Glycos_transf_3,PYNP_C LANLAPFM_01538 411490.ANACAC_03749 2.66e-21 92.8 COG2068@1|root,COG2068@2|Bacteria,1VA0F@1239|Firmicutes,24NSX@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - - NTP_transf_3 LANLAPFM_01539 622312.ROSEINA2194_03787 0.0 1268.0 COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia 186801|Clostridia C aldehyde oxidase and xanthine dehydrogenase, a b hammerhead xdhD - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 LANLAPFM_01540 622312.ROSEINA2194_03788 7.67e-87 257.0 COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24HQN@186801|Clostridia 186801|Clostridia C aerobic-type carbon monoxide dehydrogenase, small subunit CoxS hcrC - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 LANLAPFM_01541 622312.ROSEINA2194_03789 7.08e-117 342.0 COG1319@1|root,COG1319@2|Bacteria,1TSNH@1239|Firmicutes,24A57@186801|Clostridia 186801|Clostridia C Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM - - - - - - - - - - - - CO_deh_flav_C,FAD_binding_5 LANLAPFM_01542 33035.JPJF01000004_gene1973 1.07e-53 182.0 COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,24BAQ@186801|Clostridia 186801|Clostridia V PFAM SCP-like extracellular safA - - - - - - - - - - - CAP,LysM LANLAPFM_01543 553973.CLOHYLEM_07594 1.22e-134 383.0 COG0177@1|root,COG0177@2|Bacteria,1TRAK@1239|Firmicutes,24899@186801|Clostridia,21Y4Q@1506553|Lachnoclostridium 186801|Clostridia L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD LANLAPFM_01544 742765.HMPREF9457_00537 3.15e-191 542.0 COG0038@1|root,COG0038@2|Bacteria,1TPX0@1239|Firmicutes,247R4@186801|Clostridia,27WJP@189330|Dorea 186801|Clostridia P Voltage gated chloride channel eriC - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC LANLAPFM_01545 585394.RHOM_08880 3.52e-136 405.0 COG3103@1|root,COG3103@2|Bacteria,COG4991@2|Bacteria,1USNV@1239|Firmicutes,24DRI@186801|Clostridia 186801|Clostridia T Bacterial SH3 domain homologues - - - - - - - - - - - - SH3_3 LANLAPFM_01546 622312.ROSEINA2194_02768 1.98e-141 404.0 COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia 186801|Clostridia J Belongs to the pseudouridine synthase RsuA family rluF - 5.4.99.21,5.4.99.22 ko:K06178,ko:K06182 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 LANLAPFM_01547 585394.RHOM_08870 0.0 1097.0 COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia 186801|Clostridia L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 LANLAPFM_01548 622312.ROSEINA2194_02766 1.14e-204 568.0 COG1897@1|root,COG1897@2|Bacteria,1TQVR@1239|Firmicutes,247NP@186801|Clostridia 186801|Clostridia E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metAA - 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS11970 HTS LANLAPFM_01549 585394.RHOM_14390 2.66e-223 617.0 COG0280@1|root,COG0280@2|Bacteria,1TPQ0@1239|Firmicutes,247W9@186801|Clostridia 186801|Clostridia C phosphate acetyltransferase pta - 2.3.1.8 ko:K00625 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - PTA_PTB LANLAPFM_01550 585394.RHOM_14385 9.17e-256 709.0 COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia 186801|Clostridia V Mate efflux family protein - - - - - - - - - - - - MatE LANLAPFM_01551 622312.ROSEINA2194_04062 1.66e-157 451.0 COG1102@1|root,COG1102@2|Bacteria,1TSIF@1239|Firmicutes,24BT4@186801|Clostridia 186801|Clostridia F Psort location Cytoplasmic, score - - - - - - - - - - - - Cytidylate_kin2 LANLAPFM_01552 457412.RSAG_02477 5.39e-271 752.0 COG1055@1|root,COG1055@2|Bacteria,1TT1V@1239|Firmicutes,24ART@186801|Clostridia 186801|Clostridia P Na H antiporter - - - - - - - - - - - - CitMHS_2 LANLAPFM_01554 622312.ROSEINA2194_01515 0.0 926.0 COG3408@1|root,COG3408@2|Bacteria,1TPX8@1239|Firmicutes,249BI@186801|Clostridia 186801|Clostridia G Glycogen debranching enzyme - - - - - - - - - - - - GDE_C,GDE_N LANLAPFM_01556 622312.ROSEINA2194_01517 3.78e-143 407.0 COG0396@1|root,COG0396@2|Bacteria,1TQ98@1239|Firmicutes,2489I@186801|Clostridia 186801|Clostridia O FeS assembly ATPase SufC - - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran LANLAPFM_01557 622312.ROSEINA2194_01518 4.04e-205 569.0 COG0719@1|root,COG0719@2|Bacteria,1TQ21@1239|Firmicutes,249IU@186801|Clostridia 186801|Clostridia O feS assembly protein SufB - - - ko:K07033 - - - - ko00000 - - - UPF0051 LANLAPFM_01558 1280681.AUJZ01000012_gene1135 7.94e-19 82.4 2ED22@1|root,2ZVQM@2|Bacteria,1W3EW@1239|Firmicutes,256YE@186801|Clostridia,4BZ46@830|Butyrivibrio 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01559 585394.RHOM_07615 7.44e-62 196.0 COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,24QPP@186801|Clostridia 186801|Clostridia MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 LANLAPFM_01560 585394.RHOM_07620 6.77e-180 510.0 COG0337@1|root,COG0337@2|Bacteria,1TPKZ@1239|Firmicutes,248H4@186801|Clostridia 186801|Clostridia E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase LANLAPFM_01561 622312.ROSEINA2194_03750 1.03e-124 361.0 COG2302@1|root,COG2302@2|Bacteria,1U5V2@1239|Firmicutes,24GDV@186801|Clostridia 186801|Clostridia S S4 domain protein - - - - - - - - - - - - S4 LANLAPFM_01562 585394.RHOM_07630 3.65e-79 240.0 COG1799@1|root,COG1799@2|Bacteria,1V5NF@1239|Firmicutes,25CNH@186801|Clostridia 186801|Clostridia D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA sepF - - ko:K09772 - - - - ko00000,ko03036 - - - SepF LANLAPFM_01563 585394.RHOM_07635 2.36e-138 394.0 COG0325@1|root,COG0325@2|Bacteria,1TRDN@1239|Firmicutes,248R6@186801|Clostridia 186801|Clostridia S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis ylmE - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N LANLAPFM_01564 622312.ROSEINA2194_03753 4.89e-90 278.0 COG0845@1|root,COG0845@2|Bacteria,1TRN9@1239|Firmicutes,248G2@186801|Clostridia 186801|Clostridia M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - - LANLAPFM_01565 622312.ROSEINA2194_04365 8.82e-162 464.0 COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N LANLAPFM_01566 585394.RHOM_16030 1.41e-159 452.0 COG0224@1|root,COG0224@2|Bacteria,1TPBX@1239|Firmicutes,2486Q@186801|Clostridia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt LANLAPFM_01567 622312.ROSEINA2194_04367 0.0 866.0 COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,2489W@186801|Clostridia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N LANLAPFM_01568 622312.ROSEINA2194_04368 8.76e-80 238.0 COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,24ND7@186801|Clostridia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iHN637.CLJU_RS01195 ATP-synt_DE,ATP-synt_DE_N LANLAPFM_01569 622312.ROSEINA2194_03516 8.33e-250 694.0 COG0534@1|root,COG0534@2|Bacteria,1TP5P@1239|Firmicutes,247PQ@186801|Clostridia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - MatE LANLAPFM_01570 622312.ROSEINA2194_02883 1.14e-59 185.0 COG1695@1|root,COG1695@2|Bacteria,1VACN@1239|Firmicutes,24MRF@186801|Clostridia 186801|Clostridia K transcriptional regulator, PadR family - - - ko:K10947 - - - - ko00000,ko03000 - - - PadR LANLAPFM_01571 585394.RHOM_03980 5.95e-41 147.0 COG4709@1|root,COG4709@2|Bacteria,1VETQ@1239|Firmicutes,24G3G@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF1700 LANLAPFM_01573 585394.RHOM_11490 1.48e-158 460.0 COG2843@1|root,COG2843@2|Bacteria,1UCFI@1239|Firmicutes,25CHR@186801|Clostridia 186801|Clostridia M Capsule synthesis protein - - - ko:K07282 - - - - ko00000 - - - PGA_cap LANLAPFM_01574 622312.ROSEINA2194_02877 1.66e-86 273.0 COG1266@1|root,COG1266@2|Bacteria,1VCV8@1239|Firmicutes,24F20@186801|Clostridia 186801|Clostridia S CAAX amino terminal protease family protein - - - ko:K07052 - - - - ko00000 - - - Abi LANLAPFM_01575 573061.Clocel_3339 5e-78 244.0 COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1TQ2W@1239|Firmicutes,25BJI@186801|Clostridia 186801|Clostridia K Cupin domain - - - - - - - - - - - - AraC_binding LANLAPFM_01576 397291.C804_05622 3.21e-57 187.0 COG0745@1|root,COG0745@2|Bacteria,1V566@1239|Firmicutes,25EMQ@186801|Clostridia,27TZD@186928|unclassified Lachnospiraceae 186801|Clostridia KT cheY-homologous receiver domain - - - - - - - - - - - - Response_reg LANLAPFM_01577 1280682.AUKA01000005_gene2643 1.81e-134 425.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,4BWTF@830|Butyrivibrio 186801|Clostridia T Histidine Phosphotransfer domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,MASE3,Response_reg LANLAPFM_01579 622312.ROSEINA2194_00266 1.01e-39 132.0 2E7R6@1|root,3326H@2|Bacteria,1VGKC@1239|Firmicutes,24QSS@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01580 622312.ROSEINA2194_03393 0.0 1420.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia 186801|Clostridia G hydrolase, family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C LANLAPFM_01581 33035.JPJF01000004_gene1947 2.36e-154 458.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UCUQ@1239|Firmicutes,24FD5@186801|Clostridia,3Y1DI@572511|Blautia 186801|Clostridia KT helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,Response_reg LANLAPFM_01582 33035.JPJF01000004_gene1946 8.94e-193 560.0 COG2972@1|root,COG2972@2|Bacteria,1U6WN@1239|Firmicutes,257VB@186801|Clostridia,3Y13A@572511|Blautia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,His_kinase LANLAPFM_01583 33035.JPJF01000004_gene1945 3.12e-81 248.0 COG0395@1|root,COG0395@2|Bacteria,1TP1G@1239|Firmicutes,247T2@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - - - - - - - - - - BPD_transp_1 LANLAPFM_01584 33035.JPJF01000004_gene1945 3.43e-64 205.0 COG0395@1|root,COG0395@2|Bacteria,1TP1G@1239|Firmicutes,247T2@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - - - - - - - - - - BPD_transp_1 LANLAPFM_01585 180332.JTGN01000009_gene4367 2.74e-183 514.0 COG4209@1|root,COG4209@2|Bacteria,1TQFY@1239|Firmicutes,24923@186801|Clostridia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K17319 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 LANLAPFM_01586 33035.JPJF01000004_gene1943 4.51e-273 757.0 COG1653@1|root,COG1653@2|Bacteria,1TPWV@1239|Firmicutes,25NJ2@186801|Clostridia,3Y1EP@572511|Blautia 186801|Clostridia G Domain of unknown function (DUF3502) - - - - - - - - - - - - DUF3502 LANLAPFM_01587 1458462.JNLK01000001_gene1969 2.36e-21 85.1 2E7R6@1|root,3326H@2|Bacteria,1VGKC@1239|Firmicutes,24QSS@186801|Clostridia,27P7U@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01588 515620.EUBELI_20547 5.54e-63 196.0 COG1846@1|root,COG1846@2|Bacteria,1VGNE@1239|Firmicutes,25MX1@186801|Clostridia,25Z6W@186806|Eubacteriaceae 186801|Clostridia K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - - LANLAPFM_01589 515620.EUBELI_20548 0.0 1052.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,25UTB@186806|Eubacteriaceae 186801|Clostridia V ABC-type multidrug transport system, ATPase and permease - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_01590 515620.EUBELI_20549 0.0 947.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,25UVM@186806|Eubacteriaceae 186801|Clostridia V ABC-type multidrug transport system, ATPase and permease - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_01592 1256908.HMPREF0373_01324 1.12e-73 225.0 2AI96@1|root,318PT@2|Bacteria,1V7JX@1239|Firmicutes,24M2N@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_01593 1256908.HMPREF0373_01323 2.05e-45 149.0 COG1476@1|root,COG1476@2|Bacteria,1UNYA@1239|Firmicutes 1239|Firmicutes K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 LANLAPFM_01596 1410650.JHWL01000010_gene2770 1.99e-48 169.0 COG4637@1|root,COG4637@2|Bacteria,1TQ9X@1239|Firmicutes,247NI@186801|Clostridia,4BWYE@830|Butyrivibrio 186801|Clostridia K PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - AAA-ATPase_like,PDDEXK_9 LANLAPFM_01597 622312.ROSEINA2194_04392 7.72e-125 362.0 COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes,24AVJ@186801|Clostridia 186801|Clostridia C glycerophosphoryl diester phosphodiesterase - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD LANLAPFM_01598 936574.HMPREF1508_0912 1.39e-117 341.0 COG1285@1|root,COG1285@2|Bacteria,1V409@1239|Firmicutes,249SQ@186801|Clostridia 186801|Clostridia E MgtC SapB transporter - - - ko:K07507 - - - - ko00000,ko02000 9.B.20 - - MgtC LANLAPFM_01599 478749.BRYFOR_05620 1.75e-88 268.0 COG1234@1|root,COG1234@2|Bacteria,1V1J7@1239|Firmicutes,24F18@186801|Clostridia 186801|Clostridia S Beta-lactamase superfamily III - - - - - - - - - - - - Lactamase_B,Lactamase_B_2,UPF0227 LANLAPFM_01600 478749.BRYFOR_05621 1.39e-146 418.0 COG0584@1|root,COG0584@2|Bacteria,1V404@1239|Firmicutes,24EP5@186801|Clostridia 186801|Clostridia C Domain of unknown function - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - DUF4996,GDPD LANLAPFM_01601 478749.BRYFOR_05622 0.0 923.0 COG1178@1|root,COG1178@2|Bacteria,1TPMX@1239|Firmicutes,24A64@186801|Clostridia 186801|Clostridia P ABC-type Fe3 transport system permease component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 LANLAPFM_01602 478749.BRYFOR_05623 7.77e-192 538.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia 186801|Clostridia P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 LANLAPFM_01603 478749.BRYFOR_05624 1.99e-181 513.0 COG1840@1|root,COG1840@2|Bacteria,1U5IH@1239|Firmicutes 1239|Firmicutes P solute-binding protein - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6 LANLAPFM_01604 1280673.AUJJ01000001_gene2237 3.66e-139 405.0 COG1609@1|root,COG1609@2|Bacteria,1TRG8@1239|Firmicutes,249CT@186801|Clostridia,4BZ5Y@830|Butyrivibrio 186801|Clostridia K Periplasmic binding protein-like domain - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 LANLAPFM_01605 397291.C804_02930 0.0 1297.0 COG3291@1|root,COG4724@1|root,COG3291@2|Bacteria,COG4724@2|Bacteria,1TPGB@1239|Firmicutes,24AII@186801|Clostridia 186801|Clostridia G domain protein - - - - - - - - - - - - F5_F8_type_C,Glyco_hydro_85,PKD LANLAPFM_01606 702450.CUW_2164 0.0 1149.0 COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,3VPJS@526524|Erysipelotrichia 526524|Erysipelotrichia G Alpha mannosidase, middle domain - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C LANLAPFM_01607 397288.C806_01638 2.35e-189 540.0 COG3538@1|root,COG3538@2|Bacteria,1TRJI@1239|Firmicutes,248YF@186801|Clostridia,27JVW@186928|unclassified Lachnospiraceae 186801|Clostridia S Pfam:DUF1237 - - - ko:K09704 - - - - ko00000 - - - Glyco_hydro_125 LANLAPFM_01608 397288.C806_01642 2.36e-118 354.0 COG1609@1|root,COG1609@2|Bacteria,1TT82@1239|Firmicutes,24G8D@186801|Clostridia,27QNK@186928|unclassified Lachnospiraceae 186801|Clostridia K helix_turn_helix gluconate operon transcriptional repressor - - - - - - - - - - - - GntR,Peripla_BP_1 LANLAPFM_01609 397291.C804_02931 1.92e-108 325.0 COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,27UBJ@186928|unclassified Lachnospiraceae 186801|Clostridia GK ROK family glcK - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PMI_typeI,ROK LANLAPFM_01610 658086.HMPREF0994_03302 4.43e-25 97.4 COG2315@1|root,COG2315@2|Bacteria 2|Bacteria V Protein conserved in bacteria - - - - - - - - - - - - YjbR LANLAPFM_01611 585394.RHOM_00455 4.98e-186 525.0 COG2199@1|root,COG2199@2|Bacteria,1V1A1@1239|Firmicutes,24CYN@186801|Clostridia 186801|Clostridia T GGDEF domain - - - - - - - - - - - - GGDEF LANLAPFM_01612 658086.HMPREF0994_03302 1.19e-52 169.0 COG2315@1|root,COG2315@2|Bacteria 2|Bacteria V Protein conserved in bacteria - - - - - - - - - - - - YjbR LANLAPFM_01613 622312.ROSEINA2194_00846 2.5e-96 298.0 2DNG5@1|root,32XBR@2|Bacteria,1V8W9@1239|Firmicutes,24M9E@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - LprI LANLAPFM_01614 585394.RHOM_08575 4.14e-182 542.0 COG0840@1|root,COG0840@2|Bacteria,1UYFA@1239|Firmicutes,24F3M@186801|Clostridia 186801|Clostridia NT PilZ domain - - - - - - - - - - - - MCPsignal,PilZ LANLAPFM_01615 585394.RHOM_06170 0.0 1032.0 COG3867@1|root,COG3867@2|Bacteria,1TQDZ@1239|Firmicutes,24CPM@186801|Clostridia 186801|Clostridia G arabinogalactan - - 3.2.1.89 ko:K01224 - - - - ko00000,ko01000 - - - Big_4,Glyco_hydro_53 LANLAPFM_01616 1410633.JHWR01000001_gene1255 9.02e-127 395.0 COG2200@1|root,COG2200@2|Bacteria,1V15N@1239|Firmicutes,24C2G@186801|Clostridia,27K15@186928|unclassified Lachnospiraceae 186801|Clostridia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL LANLAPFM_01617 641107.CDLVIII_5763 2.81e-77 243.0 COG0834@1|root,COG0834@2|Bacteria,1TQNR@1239|Firmicutes,249Y5@186801|Clostridia,36DVN@31979|Clostridiaceae 186801|Clostridia ET Belongs to the bacterial solute-binding protein 3 family - - - ko:K02030,ko:K02424 ko02010,map02010 M00234,M00236 - - ko00000,ko00001,ko00002,ko02000,ko02035 3.A.1.3,3.A.1.3.10,3.A.1.3.14 - - SBP_bac_3 LANLAPFM_01618 641107.CDLVIII_5764 9.19e-81 248.0 COG0765@1|root,COG0765@2|Bacteria,1TPQ8@1239|Firmicutes,24BX1@186801|Clostridia,36FAP@31979|Clostridiaceae 186801|Clostridia E acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine - - - ko:K10009 ko02010,map02010 M00234 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.10,3.A.1.3.14 - - BPD_transp_1 LANLAPFM_01619 641107.CDLVIII_5765 4.76e-100 298.0 COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,247QZ@186801|Clostridia,36E89@31979|Clostridiaceae 186801|Clostridia E ABC transporter - - - ko:K10010 ko02010,map02010 M00234 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3.10,3.A.1.3.14 - - ABC_tran LANLAPFM_01620 411474.COPEUT_01236 2.1e-296 887.0 COG4124@1|root,COG4733@1|root,COG4124@2|Bacteria,COG4733@2|Bacteria,1TSXQ@1239|Firmicutes,24CRT@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 26 family - - 3.2.1.78 ko:K01218 ko00051,ko02024,map00051,map02024 - R01332 RC00467 ko00000,ko00001,ko01000 - GH26 - CBM27,CBM_11,CW_binding_1,Glyco_hydro_26,Gram_pos_anchor,SLH LANLAPFM_01622 585394.RHOM_16640 8.1e-70 214.0 COG0629@1|root,COG0629@2|Bacteria,1V3WT@1239|Firmicutes,24HF9@186801|Clostridia 186801|Clostridia L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB LANLAPFM_01623 742733.HMPREF9469_00876 2.99e-74 243.0 COG3831@1|root,COG3831@2|Bacteria 2|Bacteria - - - - 2.4.2.30 ko:K10798 ko03410,ko04210,ko04212,ko04214,ko04217,map03410,map04210,map04212,map04214,map04217 M00296 - - ko00000,ko00001,ko00002,ko01000,ko03032,ko03036,ko03400 - - - DUF4240,PARP,PARP_reg,WGR LANLAPFM_01628 585394.RHOM_11225 0.0 1295.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,248JB@186801|Clostridia 186801|Clostridia E MeTHIonine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans LANLAPFM_01629 622312.ROSEINA2194_01929 1.09e-231 640.0 COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia 186801|Clostridia J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans LANLAPFM_01630 585394.RHOM_11245 8.06e-77 240.0 COG1345@1|root,COG1345@2|Bacteria,1V9AS@1239|Firmicutes,24MHW@186801|Clostridia 186801|Clostridia N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end - - - - - - - - - - - - - LANLAPFM_01631 585394.RHOM_03830 1.62e-41 150.0 COG1404@1|root,COG1404@2|Bacteria,1TQE0@1239|Firmicutes,25B1A@186801|Clostridia 186801|Clostridia O COG COG1404 Subtilisin-like serine proteases - - - - - - - - - - - - Peptidase_S8 LANLAPFM_01632 1235790.C805_02896 5.34e-38 149.0 COG0840@1|root,COG5000@1|root,COG0840@2|Bacteria,COG5000@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,25X4C@186806|Eubacteriaceae 186801|Clostridia NT Cache domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 LANLAPFM_01633 622312.ROSEINA2194_01915 1.86e-18 87.4 COG0840@1|root,COG5000@1|root,COG0840@2|Bacteria,COG5000@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia 186801|Clostridia NT methyl-accepting chemotaxis protein - - - - - - - - - - - - HAMP,MCPsignal,dCache_1 LANLAPFM_01634 585394.RHOM_03825 4.31e-280 777.0 COG1219@1|root,COG1219@2|Bacteria,1TPDI@1239|Firmicutes,24AEG@186801|Clostridia 186801|Clostridia O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX_1 - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX LANLAPFM_01636 622312.ROSEINA2194_00348 5.11e-155 439.0 COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia 186801|Clostridia K transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR LANLAPFM_01637 585394.RHOM_03805 7.34e-222 612.0 COG0800@1|root,COG0800@2|Bacteria,1TS0F@1239|Firmicutes,248GA@186801|Clostridia 186801|Clostridia G 2-dehydro-3-deoxyphosphogluconate aldolase 4-hydroxy-2-oxoglutarate aldolase eda - 4.1.2.14,4.1.3.42 ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 M00008,M00061,M00308,M00631 R00470,R05605 RC00307,RC00308,RC00435 ko00000,ko00001,ko00002,ko01000 - - - Aldolase LANLAPFM_01638 585394.RHOM_03800 1.1e-90 266.0 COG0537@1|root,COG0537@2|Bacteria,1V3BE@1239|Firmicutes,24H73@186801|Clostridia 186801|Clostridia FG Psort location Cytoplasmic, score - - - - - - - - - - - - HIT LANLAPFM_01639 622312.ROSEINA2194_00584 1.28e-68 208.0 2ANER@1|root,315MJ@2|Bacteria,1V6SU@1239|Firmicutes,24JBZ@186801|Clostridia 186801|Clostridia S Stage V sporulation protein AE spoVAE - - ko:K06407 - - - - ko00000 - - - SpoVAC_SpoVAEB LANLAPFM_01640 585394.RHOM_03740 2.79e-191 536.0 COG0183@1|root,COG0183@2|Bacteria,1UHVW@1239|Firmicutes,248BM@186801|Clostridia 186801|Clostridia I stage v sporulation protein ad spoVAD - - ko:K06406 - - - - ko00000 - - - SpoVAD LANLAPFM_01642 622312.ROSEINA2194_00581 7.97e-37 129.0 COG1476@1|root,COG1476@2|Bacteria,1VCHW@1239|Firmicutes,24TP0@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - LANLAPFM_01643 622312.ROSEINA2194_03332 3.07e-225 644.0 COG1376@1|root,COG1376@2|Bacteria,1TQMA@1239|Firmicutes,248H0@186801|Clostridia 186801|Clostridia M ErfK YbiS YcfS YnhG - - - - - - - - - - - - PG_binding_4,YkuD LANLAPFM_01644 585394.RHOM_11030 1.51e-128 369.0 COG0671@1|root,COG0671@2|Bacteria,1V2ZH@1239|Firmicutes,24HRY@186801|Clostridia 186801|Clostridia I Psort location CytoplasmicMembrane, score - - - - - - - - - - - - PAP2,PAP2_3 LANLAPFM_01645 1408324.JNJK01000005_gene1128 2.87e-193 549.0 COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,27JK2@186928|unclassified Lachnospiraceae 186801|Clostridia F Amidohydrolase family guaD - 3.5.4.3 ko:K01487 ko00230,ko01100,map00230,map01100 - R01676 RC00204 ko00000,ko00001,ko01000 - - - Amidohydro_1 LANLAPFM_01646 622312.ROSEINA2194_03329 3.27e-259 713.0 COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia 186801|Clostridia C aldo keto reductase - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red,Fer4_17 LANLAPFM_01647 622312.ROSEINA2194_03328 0.0 1029.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia 186801|Clostridia H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase LANLAPFM_01648 622312.ROSEINA2194_03327 6.41e-169 476.0 COG1281@1|root,COG1281@2|Bacteria,1TRCH@1239|Firmicutes,24940@186801|Clostridia 186801|Clostridia O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress hslO - - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 LANLAPFM_01649 585394.RHOM_04475 2.08e-128 372.0 COG4976@1|root,COG4976@2|Bacteria,1UHZM@1239|Firmicutes,24A6U@186801|Clostridia 186801|Clostridia S Methyltransferase domain protein - - - - - - - - - - - - Methyltransf_25 LANLAPFM_01650 585394.RHOM_04470 1.23e-183 519.0 28JB6@1|root,2Z960@2|Bacteria,1U83T@1239|Firmicutes,24BAY@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01651 585394.RHOM_04465 1.46e-101 295.0 COG0440@1|root,COG0440@2|Bacteria,1V3PG@1239|Firmicutes,24A0D@186801|Clostridia 186801|Clostridia E acetolactate synthase, small - - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C LANLAPFM_01652 585394.RHOM_04460 0.0 1076.0 COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia 186801|Clostridia H Acetolactate synthase, large subunit ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N LANLAPFM_01653 585394.RHOM_04455 1.56e-194 543.0 COG0679@1|root,COG0679@2|Bacteria,1TR9W@1239|Firmicutes,24AQF@186801|Clostridia 186801|Clostridia S Transporter, auxin efflux carrier (AEC) family protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans LANLAPFM_01654 585394.RHOM_04450 3.45e-97 284.0 COG0262@1|root,COG0262@2|Bacteria,1VB80@1239|Firmicutes,24FTH@186801|Clostridia 186801|Clostridia H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis folA - 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 - - - DHFR_1 LANLAPFM_01655 585394.RHOM_04440 4.59e-31 110.0 2DRX4@1|root,33DGR@2|Bacteria,1VKQ3@1239|Firmicutes,24URP@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01656 585394.RHOM_04435 5.16e-67 207.0 COG3976@1|root,COG3976@2|Bacteria,1V72R@1239|Firmicutes,24JFD@186801|Clostridia 186801|Clostridia S FMN-binding domain protein - - - - - - - - - - - - - LANLAPFM_01657 1469948.JPNB01000001_gene446 7.43e-144 446.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,36E1W@31979|Clostridiaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,dCache_1 LANLAPFM_01658 622312.ROSEINA2194_03508 0.0 1065.0 COG0008@1|root,COG0008@2|Bacteria,1TP8G@1239|Firmicutes,247Y0@186801|Clostridia 186801|Clostridia J Glutaminyl-tRNA synthetase glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C LANLAPFM_01659 585394.RHOM_05560 2.32e-147 421.0 COG1655@1|root,COG1655@2|Bacteria,1V2CM@1239|Firmicutes,25CK4@186801|Clostridia 186801|Clostridia S Uncharacterized protein conserved in bacteria (DUF2225) - - - ko:K09766 - - - - ko00000 - - - DUF2225 LANLAPFM_01660 585394.RHOM_05565 1.39e-228 643.0 COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia 186801|Clostridia K aminotransferase class I and II - - - ko:K00375 - - - - ko00000,ko03000 - - - Aminotran_1_2,GntR LANLAPFM_01661 1226325.HMPREF1548_00426 3.54e-89 268.0 28PR6@1|root,2ZCD4@2|Bacteria,1VRUS@1239|Firmicutes,25DRA@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01662 585394.RHOM_04970 5.48e-218 606.0 COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,247K2@186801|Clostridia 186801|Clostridia K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg LANLAPFM_01663 585394.RHOM_04975 4.32e-76 235.0 COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia 186801|Clostridia O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE LANLAPFM_01664 622312.ROSEINA2194_01132 0.0 1134.0 COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia 186801|Clostridia O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 LANLAPFM_01666 622312.ROSEINA2194_02475 0.0 1424.0 COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia 186801|Clostridia O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695,ko:K03696 ko01100,ko04213,map01100,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N LANLAPFM_01667 483218.BACPEC_01903 1.88e-266 735.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,2685U@186813|unclassified Clostridiales 186801|Clostridia V Polysaccharide biosynthesis C-terminal domain - - - - - - - - - - - - MatE LANLAPFM_01668 585394.RHOM_03595 9.4e-169 475.0 COG4667@1|root,COG4667@2|Bacteria,1TQ9W@1239|Firmicutes,2485C@186801|Clostridia 186801|Clostridia S Phospholipase, patatin family - - - - - - - - - - - - Patatin LANLAPFM_01669 1280696.ATVY01000004_gene422 8.93e-98 290.0 COG0637@1|root,COG0637@2|Bacteria,1UZE0@1239|Firmicutes,24DWR@186801|Clostridia,4BY5V@830|Butyrivibrio 186801|Clostridia S Haloacid dehalogenase-like hydrolase pgmB - 5.4.2.6 ko:K01838 ko00500,map00500 - R02728,R11310 RC00408 ko00000,ko00001,ko01000 - - - HAD_2 LANLAPFM_01670 634956.Geoth_2958 5.9e-81 257.0 COG1609@1|root,COG1609@2|Bacteria,1TRFH@1239|Firmicutes,4HBNT@91061|Bacilli,1WFIB@129337|Geobacillus 91061|Bacilli K helix_turn _helix lactose operon repressor cytR - - ko:K02529,ko:K03604 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 LANLAPFM_01671 610130.Closa_0867 3.57e-135 403.0 COG1653@1|root,COG1653@2|Bacteria,1TR0C@1239|Firmicutes,248RD@186801|Clostridia,221RJ@1506553|Lachnoclostridium 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_8 LANLAPFM_01672 180332.JTGN01000002_gene5509 9.27e-141 406.0 COG1175@1|root,COG1175@2|Bacteria,1TRU7@1239|Firmicutes,24AIC@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 LANLAPFM_01673 180332.JTGN01000002_gene5510 1.54e-126 368.0 COG0395@1|root,COG0395@2|Bacteria,1TRXW@1239|Firmicutes,25C4N@186801|Clostridia 186801|Clostridia P ABC-type sugar transport system, permease component - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 LANLAPFM_01674 610130.Closa_0870 1.41e-259 753.0 COG0637@1|root,COG1554@1|root,COG0637@2|Bacteria,COG1554@2|Bacteria,1TQMB@1239|Firmicutes,247J6@186801|Clostridia,223W0@1506553|Lachnoclostridium 186801|Clostridia G hydrolase family 65 central catalytic - - 2.4.1.230,2.4.1.8 ko:K00691,ko:K04844,ko:K10231 ko00500,ko01100,map00500,map01100 - R01555 RC00049 ko00000,ko00001,ko01000 - GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2 LANLAPFM_01675 556261.HMPREF0240_04156 4e-35 130.0 COG5578@1|root,COG5578@2|Bacteria,1V3XD@1239|Firmicutes,24K78@186801|Clostridia,36KAQ@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function, DUF624 - - - - - - - - - - - - DUF624 LANLAPFM_01676 537007.BLAHAN_05096 6.75e-310 875.0 COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,24A10@186801|Clostridia,3XZ46@572511|Blautia 186801|Clostridia G Domain of unknown function (DUF5110) - - - - - - - - - - - - DUF4968,DUF5110,Glyco_hydro_31 LANLAPFM_01677 1280676.AUJO01000012_gene3474 0.0 929.0 COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia,4BYXB@830|Butyrivibrio 186801|Clostridia G Alpha-amylase domain malL - 3.2.1.1,3.2.1.10 ko:K01176,ko:K01182 ko00052,ko00500,ko01100,ko04973,map00052,map00500,map01100,map04973 - R00801,R01718,R01791,R02108,R02112,R06199,R11262 RC00028,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3459,Malt_amylase_C LANLAPFM_01678 397291.C804_03982 0.0 1011.0 COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia,27K0D@186928|unclassified Lachnospiraceae 186801|Clostridia G Carbohydrate-binding module 48 (Isoamylase N-terminal domain) pulA - 3.2.1.41 ko:K01200 ko00500,ko01100,ko01110,map00500,map01100,map01110 - R02111 - ko00000,ko00001,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3372,PUD LANLAPFM_01679 585394.RHOM_03610 0.0 1999.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia 186801|Clostridia L DNA polymerase III, alpha subunit dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon LANLAPFM_01680 585394.RHOM_03615 2.02e-221 612.0 COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,248PB@186801|Clostridia 186801|Clostridia F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK LANLAPFM_01681 622312.ROSEINA2194_02470 2.04e-131 380.0 COG0566@1|root,COG0566@2|Bacteria,1V3JP@1239|Firmicutes,248DV@186801|Clostridia 186801|Clostridia J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family spoU - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind LANLAPFM_01682 622312.ROSEINA2194_02469 2.72e-51 162.0 2CGVU@1|root,32S4Q@2|Bacteria,1V9YX@1239|Firmicutes,24NX8@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_01683 633697.EubceDRAFT1_0116 2.64e-117 338.0 COG2184@1|root,COG2184@2|Bacteria,1TPUZ@1239|Firmicutes,248XF@186801|Clostridia,25W8Z@186806|Eubacteriaceae 186801|Clostridia D Fic/DOC family fic - - ko:K04095 - - - - ko00000,ko03036 - - - Bro-N,Fic LANLAPFM_01684 411461.DORFOR_02133 9.9e-280 771.0 COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,27WEJ@189330|Dorea 186801|Clostridia E Sodium:alanine symporter family - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp LANLAPFM_01685 622312.ROSEINA2194_00442 3.26e-282 776.0 COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia 186801|Clostridia S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF LANLAPFM_01686 1458462.JNLK01000001_gene4 1.29e-80 246.0 28HI8@1|root,2Z9QV@2|Bacteria,1UZZ2@1239|Firmicutes,24IH2@186801|Clostridia,27MEA@186928|unclassified Lachnospiraceae 186801|Clostridia S Domain of unknown function (DUF4317) - - - - - - - - - - - - DUF4317 LANLAPFM_01688 515620.EUBELI_20098 1.11e-187 533.0 COG2206@1|root,COG2206@2|Bacteria,1TS2E@1239|Firmicutes,249S8@186801|Clostridia,25WUW@186806|Eubacteriaceae 186801|Clostridia T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD,HD_5 LANLAPFM_01689 585394.RHOM_04910 0.0 1226.0 COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF LANLAPFM_01690 585394.RHOM_04905 2.9e-191 550.0 COG0116@1|root,COG0116@2|Bacteria,1TT5F@1239|Firmicutes,249VY@186801|Clostridia 186801|Clostridia L Putative RNA methylase family UPF0020 - - - - - - - - - - - - HEAT_2,UPF0020 LANLAPFM_01691 585394.RHOM_04900 2.79e-105 310.0 COG5632@1|root,COG5632@2|Bacteria,1V3JT@1239|Firmicutes,24D7K@186801|Clostridia 186801|Clostridia M n-acetylmuramoyl-l-alanine amidase - - 3.5.1.28 ko:K01447 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - Amidase_2 LANLAPFM_01692 1163671.JAGI01000002_gene2605 2.72e-27 107.0 COG5578@1|root,COG5578@2|Bacteria,1TV7X@1239|Firmicutes,24QU0@186801|Clostridia 186801|Clostridia S Protein of unknown function, DUF624 - - - - - - - - - - - - DUF624 LANLAPFM_01693 1280390.CBQR020000071_gene1456 0.0 932.0 2DB7A@1|root,2Z7KK@2|Bacteria,1TQ2C@1239|Firmicutes,4HFKE@91061|Bacilli,26S01@186822|Paenibacillaceae 91061|Bacilli S Glycosyl hydrolase family 115 - - - - - - - - - - - - Glyco_hydro_115 LANLAPFM_01694 1163671.JAGI01000002_gene2604 1.26e-271 759.0 COG2755@1|root,COG2755@2|Bacteria,1TPYH@1239|Firmicutes,2486S@186801|Clostridia,36VIB@31979|Clostridiaceae 186801|Clostridia E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - CBM_4_9,Lipase_GDSL_2 LANLAPFM_01695 622312.ROSEINA2194_04241 4.55e-243 669.0 COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia 186801|Clostridia E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC LANLAPFM_01696 585394.RHOM_05585 1.94e-86 258.0 COG0454@1|root,COG0456@2|Bacteria,1V4GU@1239|Firmicutes,24IME@186801|Clostridia 186801|Clostridia K Acetyltransferase, gnat family RimI - 2.3.1.1 ko:K22477 ko00220,ko01210,ko01230,map00220,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1,Acetyltransf_10 LANLAPFM_01697 622312.ROSEINA2194_03939 4.13e-249 689.0 COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia 186801|Clostridia E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ LANLAPFM_01698 585394.RHOM_05595 1.95e-195 544.0 COG0548@1|root,COG0548@2|Bacteria,1TP0N@1239|Firmicutes,2486J@186801|Clostridia 186801|Clostridia E Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase LANLAPFM_01699 585394.RHOM_05600 5.23e-247 682.0 COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia 186801|Clostridia E PFAM Aminotransferase class-III argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 LANLAPFM_01700 585394.RHOM_05605 3.02e-142 416.0 COG2182@1|root,COG2182@2|Bacteria,1V0VV@1239|Firmicutes,24E7F@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_8 LANLAPFM_01701 622312.ROSEINA2194_03945 5.28e-51 171.0 COG1555@1|root,COG1555@2|Bacteria,1VA3W@1239|Firmicutes,24MQF@186801|Clostridia 186801|Clostridia L TIGRFAM Competence protein ComEA, helix-hairpin-helix comEA - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3,SLBB LANLAPFM_01702 585394.RHOM_05615 2.59e-161 452.0 COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,248Z4@186801|Clostridia 186801|Clostridia T response regulator receiver - - - - - - - - - - - - Response_reg,Trans_reg_C LANLAPFM_01703 585394.RHOM_05620 1.29e-273 757.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia 186801|Clostridia T Histidine kinase - - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA LANLAPFM_01704 585394.RHOM_05625 2.47e-162 462.0 COG5401@1|root,COG5401@2|Bacteria,1UXYS@1239|Firmicutes,24EK4@186801|Clostridia 186801|Clostridia S Sporulation and spore germination - - - ko:K06298 - - - - ko00000 - - - Germane LANLAPFM_01705 585394.RHOM_05630 8.16e-180 544.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia 186801|Clostridia M Competence protein ComEC - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B LANLAPFM_01706 622312.ROSEINA2194_03952 1.19e-187 526.0 COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,24ASN@186801|Clostridia 186801|Clostridia L DNA polymerase III (delta' subunit) holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta LANLAPFM_01707 585394.RHOM_05640 1.11e-41 138.0 COG0268@1|root,COG0268@2|Bacteria,1VEGX@1239|Firmicutes,24QNX@186801|Clostridia 186801|Clostridia J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p LANLAPFM_01708 585394.RHOM_05645 4.46e-184 518.0 COG0680@1|root,COG0680@2|Bacteria,1TPFY@1239|Firmicutes,248TE@186801|Clostridia 186801|Clostridia C Initiates the rapid degradation of small, acid-soluble proteins during spore germination gpr - 3.4.24.78 ko:K06012 - - - - ko00000,ko01000,ko01002 - - - Peptidase_A25 LANLAPFM_01709 585394.RHOM_05650 6.82e-168 486.0 COG0860@1|root,COG0860@2|Bacteria,1TSFS@1239|Firmicutes,2488U@186801|Clostridia 186801|Clostridia M stage II sporulation protein P spoIIP - - ko:K06385 - - - - ko00000 - - - SpoIIP LANLAPFM_01710 585394.RHOM_05655 4.76e-77 235.0 COG0671@1|root,COG0671@2|Bacteria,1VB7J@1239|Firmicutes,24JDD@186801|Clostridia 186801|Clostridia I Psort location CytoplasmicMembrane, score - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - PAP2 LANLAPFM_01711 622312.ROSEINA2194_03960 0.0 898.0 COG0367@1|root,COG0367@2|Bacteria,1TRPB@1239|Firmicutes,247YA@186801|Clostridia 186801|Clostridia E Asparagine synthase, glutamine-hydrolyzing asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 LANLAPFM_01712 622312.ROSEINA2194_02849 2.51e-254 734.0 COG2206@1|root,COG2206@2|Bacteria,1V6WM@1239|Firmicutes,24FPG@186801|Clostridia 186801|Clostridia T metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - GAF_2,GAF_3,GGDEF,HD,HD_5,HisKA_7TM LANLAPFM_01713 1469948.JPNB01000001_gene792 1.34e-66 212.0 COG5523@1|root,COG5523@2|Bacteria,1V6FC@1239|Firmicutes,24JPX@186801|Clostridia,36WXQ@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function (DUF975) - - - - - - - - - - - - DUF975 LANLAPFM_01714 585394.RHOM_05735 8.9e-303 841.0 COG1404@1|root,COG1404@2|Bacteria,1TQK9@1239|Firmicutes,25B1U@186801|Clostridia 186801|Clostridia O Belongs to the peptidase S8 family cspBA - - - - - - - - - - - Peptidase_S8 LANLAPFM_01715 1469948.JPNB01000003_gene64 1.58e-93 282.0 COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,247R1@186801|Clostridia,36H17@31979|Clostridiaceae 186801|Clostridia D Cellulose biosynthesis protein BcsQ - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 LANLAPFM_01716 658086.HMPREF0994_03796 1.23e-190 553.0 COG3509@1|root,COG3509@2|Bacteria,1UZP5@1239|Firmicutes,24AU4@186801|Clostridia 186801|Clostridia Q Esterase PHB depolymerase - - - - - - - - - - - - CW_binding_1,Esterase_phd LANLAPFM_01717 658086.HMPREF0994_03648 3.05e-168 476.0 COG4209@1|root,COG4209@2|Bacteria,1TSTC@1239|Firmicutes,24AFM@186801|Clostridia,27M8N@186928|unclassified Lachnospiraceae 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02025,ko:K17319 ko02010,map02010 M00207,M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 LANLAPFM_01718 658086.HMPREF0994_03647 2.34e-142 410.0 COG0395@1|root,COG0395@2|Bacteria,1TRB1@1239|Firmicutes,2488P@186801|Clostridia,27MH0@186928|unclassified Lachnospiraceae 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02026,ko:K17320 ko02010,map02010 M00207,M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 LANLAPFM_01719 1280680.AUJU01000017_gene3826 3.26e-211 608.0 COG1653@1|root,COG1653@2|Bacteria,1V0Q4@1239|Firmicutes,24CCN@186801|Clostridia,4BYEJ@830|Butyrivibrio 186801|Clostridia G transport - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1 LANLAPFM_01720 658086.HMPREF0994_03797 1.97e-79 254.0 COG1609@1|root,COG1609@2|Bacteria,1V22B@1239|Firmicutes,24FZB@186801|Clostridia 186801|Clostridia K Periplasmic binding protein LacI transcriptional regulator - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 LANLAPFM_01721 658086.HMPREF0994_03785 1.78e-311 877.0 COG2382@1|root,COG2382@2|Bacteria,1V888@1239|Firmicutes,24CN5@186801|Clostridia,27M6U@186928|unclassified Lachnospiraceae 186801|Clostridia P Putative esterase - - - - - - - - - - - - CBM_6,Dockerin_1,Esterase LANLAPFM_01722 1280666.ATVS01000025_gene2877 1.54e-301 832.0 COG3534@1|root,COG3534@2|Bacteria,1VS1P@1239|Firmicutes,24BH3@186801|Clostridia,4C1VY@830|Butyrivibrio 186801|Clostridia G Alpha-L-arabinofuranosidase C-terminus - - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C LANLAPFM_01723 1227349.C170_17832 2.18e-56 188.0 COG0627@1|root,COG0627@2|Bacteria,1TPA9@1239|Firmicutes,4HD64@91061|Bacilli,26RX9@186822|Paenibacillaceae 91061|Bacilli S esterase estA - - ko:K03930 - - - - ko00000,ko01000 - CE1 - Esterase LANLAPFM_01724 1336245.JAGO01000001_gene1090 7.56e-43 153.0 COG0627@1|root,COG0627@2|Bacteria,1N3VN@1224|Proteobacteria,1RYER@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative esterase - - - - - - - - - - - - Esterase LANLAPFM_01726 877418.ATWV01000004_gene1861 1.9e-203 579.0 COG0534@1|root,COG0534@2|Bacteria,2J674@203691|Spirochaetes 203691|Spirochaetes V Mate efflux family protein - - - - - - - - - - - - MatE LANLAPFM_01727 658086.HMPREF0994_03645 0.0 903.0 COG1653@1|root,COG3693@1|root,COG1653@2|Bacteria,COG3693@2|Bacteria,1UHTC@1239|Firmicutes,248KD@186801|Clostridia,27JSU@186928|unclassified Lachnospiraceae 186801|Clostridia G Glycosyl hydrolase family 10 - - 3.2.1.8 ko:K01181 - - - - ko00000,ko01000 - - - Abhydrolase_3,Beta_helix,Glyco_hydro_10,Peptidase_S9 LANLAPFM_01728 658086.HMPREF0994_03639 0.0 956.0 COG3534@1|root,COG3534@2|Bacteria,1TPG2@1239|Firmicutes,24AVP@186801|Clostridia 186801|Clostridia G Alpha-L-arabinofuranosidase C-terminus - - - - - - - - - - - - Alpha-L-AF_C,Cadherin-like,DUF1080 LANLAPFM_01729 585394.RHOM_05755 1.69e-117 363.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia 186801|Clostridia G hydrolase, family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C LANLAPFM_01730 1235792.C808_04909 1.72e-51 165.0 COG1943@1|root,COG1943@2|Bacteria,1TSQ0@1239|Firmicutes,25CMS@186801|Clostridia,27U60@186928|unclassified Lachnospiraceae 186801|Clostridia L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp LANLAPFM_01731 1256908.HMPREF0373_02042 5.47e-176 489.0 COG3910@1|root,COG3910@2|Bacteria,1TSWP@1239|Firmicutes,249W3@186801|Clostridia,25UUH@186806|Eubacteriaceae 186801|Clostridia S AAA domain - - - - - - - - - - - - AAA_15,AAA_21,AAA_23 LANLAPFM_01732 518637.EUBIFOR_00731 2.23e-126 360.0 COG2020@1|root,COG2020@2|Bacteria,1V3IZ@1239|Firmicutes 1239|Firmicutes O Isoprenylcysteine carboxyl methyltransferase - - - - - - - - - - - - DUF218,PEMT LANLAPFM_01733 397291.C804_04886 2.35e-90 276.0 COG4977@1|root,COG4977@2|Bacteria,1UJZB@1239|Firmicutes,25FFH@186801|Clostridia,27NE9@186928|unclassified Lachnospiraceae 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 LANLAPFM_01734 1226325.HMPREF1548_05324 3.74e-246 690.0 COG3664@1|root,COG3664@2|Bacteria,1TQGI@1239|Firmicutes,2490Q@186801|Clostridia,36GCA@31979|Clostridiaceae 186801|Clostridia K family 39 - - 3.2.1.37 ko:K01198 ko00520,ko01100,map00520,map01100 - R01433 RC00467 ko00000,ko00001,ko01000 - GH43 - AraC_binding,Glyco_hydro_39,HTH_18 LANLAPFM_01735 585394.RHOM_10910 1.69e-89 268.0 COG0789@1|root,COG0789@2|Bacteria,1V1M9@1239|Firmicutes,24FUE@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - DUF1836 LANLAPFM_01736 585394.RHOM_10915 1.08e-60 187.0 COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes,24MX9@186801|Clostridia 186801|Clostridia S protein, YerC YecD - - - - - - - - - - - - Trp_repressor LANLAPFM_01737 585394.RHOM_10920 1.9e-97 296.0 COG1266@1|root,COG1266@2|Bacteria,1VF60@1239|Firmicutes,24QSC@186801|Clostridia 186801|Clostridia S CAAX amino terminal protease family protein - - - ko:K07052 - - - - ko00000 - - - Abi LANLAPFM_01738 622312.ROSEINA2194_02313 6.58e-217 603.0 COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia 186801|Clostridia E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 LANLAPFM_01739 585394.RHOM_10930 1.96e-247 684.0 COG0436@1|root,COG0436@2|Bacteria,1TP36@1239|Firmicutes,248ZV@186801|Clostridia 186801|Clostridia E Aminotransferase yhdR - 2.6.1.1 ko:K11358 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 LANLAPFM_01740 585394.RHOM_08930 3.92e-110 318.0 COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,24JFS@186801|Clostridia 186801|Clostridia L Hydrolase, nudix family nudF - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS05505 NUDIX LANLAPFM_01742 585394.RHOM_13875 5.06e-125 362.0 COG0745@1|root,COG0745@2|Bacteria,1UDAQ@1239|Firmicutes,249RQ@186801|Clostridia 186801|Clostridia KT COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain kdpE_1 - - ko:K07667 ko02020,ko02024,map02020,map02024 M00454 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C LANLAPFM_01744 622312.ROSEINA2194_01216 4.61e-289 799.0 COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,248G8@186801|Clostridia 186801|Clostridia M Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 LANLAPFM_01745 411463.EUBVEN_01846 4.16e-30 107.0 COG3655@1|root,COG3655@2|Bacteria,1VEM0@1239|Firmicutes,24QPN@186801|Clostridia,25XUQ@186806|Eubacteriaceae 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_26 LANLAPFM_01746 515620.EUBELI_01774 3.94e-16 78.2 COG3206@1|root,COG3206@2|Bacteria,1TR5K@1239|Firmicutes,24ARC@186801|Clostridia,25VZP@186806|Eubacteriaceae 186801|Clostridia M Psort location Cytoplasmic, score - - - - - - - - - - - - Mob_Pre LANLAPFM_01747 585394.RHOM_00325 1.23e-129 377.0 COG0697@1|root,COG0697@2|Bacteria,1V1H0@1239|Firmicutes,24BBW@186801|Clostridia 186801|Clostridia EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA LANLAPFM_01748 203119.Cthe_3129 1.77e-140 411.0 COG1055@1|root,COG1055@2|Bacteria,1TQCH@1239|Firmicutes,25CD7@186801|Clostridia,3WGPH@541000|Ruminococcaceae 186801|Clostridia P Citrate transporter - - - - - - - - - - - - CitMHS LANLAPFM_01749 585394.RHOM_00310 3.65e-196 551.0 COG1014@1|root,COG1144@1|root,COG1014@2|Bacteria,COG1144@2|Bacteria,1TRFJ@1239|Firmicutes,24A29@186801|Clostridia 186801|Clostridia C oxidoreductase gamma subunit - - 1.2.7.1 ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,POR LANLAPFM_01750 585394.RHOM_00305 0.0 1202.0 COG0674@1|root,COG1013@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia 186801|Clostridia C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K00169,ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N,TPP_enzyme_C LANLAPFM_01751 1408323.JQKK01000024_gene1322 1.57e-10 58.2 2DQE4@1|root,3368Z@2|Bacteria,1VJUF@1239|Firmicutes,24UJT@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01752 411459.RUMOBE_02697 1.8e-269 739.0 COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,25E7B@186801|Clostridia,3Y0YH@572511|Blautia 186801|Clostridia H Aminotransferase class-III bioA - 2.6.1.113,2.6.1.55,2.6.1.62,2.6.1.77 ko:K00833,ko:K03851,ko:K12256,ko:K15372 ko00330,ko00410,ko00430,ko00780,ko01100,map00330,map00410,map00430,map00780,map01100 M00123,M00573,M00577 R00908,R01684,R03231,R05652,R08714 RC00006,RC00008,RC00062,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 LANLAPFM_01753 411459.RUMOBE_02698 8.71e-130 372.0 COG0132@1|root,COG0132@2|Bacteria,1UYA3@1239|Firmicutes,24F15@186801|Clostridia,3Y0X3@572511|Blautia 186801|Clostridia H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD - 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 - - - AAA_26 LANLAPFM_01754 411459.RUMOBE_02699 4.07e-219 606.0 COG0502@1|root,COG0502@2|Bacteria,1TPQ4@1239|Firmicutes,248J4@186801|Clostridia,3XYUJ@572511|Blautia 186801|Clostridia H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM LANLAPFM_01755 411459.RUMOBE_02700 8.28e-95 280.0 COG1268@1|root,COG1268@2|Bacteria,1VAY6@1239|Firmicutes,24HU5@186801|Clostridia,3Y18Q@572511|Blautia 186801|Clostridia S BioY family bioY - - ko:K03523 ko02010,map02010 M00581,M00582 - - ko00000,ko00001,ko00002,ko02000 2.A.88.1,2.A.88.2 - - BioY LANLAPFM_01757 585394.RHOM_00275 6.16e-154 437.0 COG0561@1|root,COG0561@2|Bacteria,1UFDJ@1239|Firmicutes,25B6S@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - Hydrolase_3 LANLAPFM_01758 1235793.C809_01302 1.74e-126 383.0 2BP58@1|root,32HW3@2|Bacteria,1V8J8@1239|Firmicutes,24HB1@186801|Clostridia,27PAY@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - DUF4367 LANLAPFM_01759 622312.ROSEINA2194_02923 2.61e-68 211.0 COG1595@1|root,COG1595@2|Bacteria,1VACS@1239|Firmicutes,24KS7@186801|Clostridia 186801|Clostridia K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 LANLAPFM_01761 622312.ROSEINA2194_02236 1.79e-287 786.0 COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia 186801|Clostridia J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b LANLAPFM_01762 632245.CLP_0713 1.51e-133 385.0 COG0657@1|root,COG0657@2|Bacteria,1TP1H@1239|Firmicutes,24D7F@186801|Clostridia,36E3F@31979|Clostridiaceae 186801|Clostridia I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3,Peptidase_S9 LANLAPFM_01764 1235802.C823_05092 1.86e-121 386.0 COG1948@1|root,COG4880@2|Bacteria,1TQK0@1239|Firmicutes,247VC@186801|Clostridia,25WEQ@186806|Eubacteriaceae 186801|Clostridia L Beta propeller domain - - - - - - - - - - - - Beta_propel LANLAPFM_01765 1235802.C823_05093 9.92e-64 201.0 COG1595@1|root,COG1595@2|Bacteria,1V6SV@1239|Firmicutes,24HPR@186801|Clostridia,25X89@186806|Eubacteriaceae 186801|Clostridia K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_ECF,Sigma70_r2,Sigma70_r4,Sigma70_r4_2 LANLAPFM_01766 903814.ELI_2151 3.07e-288 810.0 COG2015@1|root,COG2015@2|Bacteria,1TR7Q@1239|Firmicutes,248SN@186801|Clostridia,25Y8G@186806|Eubacteriaceae 186801|Clostridia Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B LANLAPFM_01767 633147.Olsu_0240 3.39e-202 573.0 COG5361@1|root,COG5361@2|Bacteria,2GRDZ@201174|Actinobacteria,4CX4F@84998|Coriobacteriia 84998|Coriobacteriia S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 LANLAPFM_01768 500632.CLONEX_03904 1.23e-85 259.0 COG0546@1|root,COG0546@2|Bacteria,1V1FQ@1239|Firmicutes,24G1U@186801|Clostridia 186801|Clostridia F Psort location Cytoplasmic, score nt5e - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 LANLAPFM_01769 622312.ROSEINA2194_04469 5.1e-201 566.0 COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia 186801|Clostridia E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins - - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 LANLAPFM_01770 585394.RHOM_05120 1.17e-190 545.0 COG2244@1|root,COG2244@2|Bacteria,1TNYX@1239|Firmicutes,2485G@186801|Clostridia 186801|Clostridia S Stage V sporulation protein B spoVB - - ko:K06409 - - - - ko00000,ko02000 2.A.66.2.14 - - Polysacc_synt,Polysacc_synt_C LANLAPFM_01771 483218.BACPEC_02966 2.2e-111 333.0 COG0484@1|root,COG0484@2|Bacteria,1TS44@1239|Firmicutes,24A9N@186801|Clostridia,26A1M@186813|unclassified Clostridiales 186801|Clostridia O DnaJ molecular chaperone homology domain CbpA - - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C LANLAPFM_01772 904296.HMPREF9124_0179 9.06e-202 563.0 COG1609@1|root,COG1609@2|Bacteria,1TS5M@1239|Firmicutes,24AWP@186801|Clostridia,2PSM6@265975|Oribacterium 186801|Clostridia K helix_turn _helix lactose operon repressor - - - - - - - - - - - - LacI,Peripla_BP_3 LANLAPFM_01773 411459.RUMOBE_02566 0.0 1713.0 COG0642@1|root,COG0784@1|root,COG0834@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,3Y28F@572511|Blautia 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg,SBP_bac_3 LANLAPFM_01774 585394.RHOM_02460 0.0 1009.0 COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia 186801|Clostridia F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS01075 CTP_synth_N,GATase LANLAPFM_01775 1408306.JHXX01000009_gene3377 1.66e-94 292.0 COG0860@1|root,COG0860@2|Bacteria,1UY5Q@1239|Firmicutes,247Y6@186801|Clostridia,4BWSH@830|Butyrivibrio 186801|Clostridia M Ami_3 - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3,SH3_3 LANLAPFM_01776 585394.RHOM_02455 6.18e-35 119.0 2EGE3@1|root,33A60@2|Bacteria,1VMF7@1239|Firmicutes,24UMV@186801|Clostridia 186801|Clostridia S Psort location - - - - - - - - - - - - - LANLAPFM_01778 411474.COPEUT_02877 1.42e-17 75.5 2EG1V@1|root,339TV@2|Bacteria,1VKAZ@1239|Firmicutes,24UGV@186801|Clostridia 186801|Clostridia S COG NOG17973 non supervised orthologous group - - - - - - - - - - - - DUF4250 LANLAPFM_01779 585394.RHOM_02440 3.24e-97 286.0 COG1451@1|root,COG1451@2|Bacteria,1UJII@1239|Firmicutes 1239|Firmicutes S Protein of unknown function DUF45 - - - ko:K07043 - - - - ko00000 - - - DUF45 LANLAPFM_01780 478749.BRYFOR_05176 6.13e-222 624.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia 186801|Clostridia V Mate efflux family protein - - - - - - - - - - - - MatE LANLAPFM_01781 622312.ROSEINA2194_00484 5.63e-206 604.0 COG0369@1|root,COG0534@1|root,COG0534@2|Bacteria,COG1151@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia 186801|Clostridia V MATE efflux family protein - - - - - - - - - - - - MatE LANLAPFM_01782 585394.RHOM_02135 8.13e-137 395.0 COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia 186801|Clostridia C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 LANLAPFM_01783 483218.BACPEC_02964 1.01e-36 127.0 COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia,269QT@186813|unclassified Clostridiales 186801|Clostridia O Thioredoxin-like domain trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin LANLAPFM_01784 585394.RHOM_02150 3.86e-81 242.0 COG1846@1|root,COG1846@2|Bacteria,1V6G0@1239|Firmicutes,24K11@186801|Clostridia 186801|Clostridia K transcriptional regulator ohrR - - - - - - - - - - - MarR LANLAPFM_01785 585394.RHOM_01250 1.71e-161 468.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Response_reg LANLAPFM_01786 478749.BRYFOR_08058 7.99e-97 304.0 COG1396@1|root,COG1396@2|Bacteria,1VBK2@1239|Firmicutes,24N6F@186801|Clostridia 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3,TPR_8 LANLAPFM_01787 478749.BRYFOR_08059 1.34e-187 535.0 COG0477@1|root,COG2814@2|Bacteria,1TZWA@1239|Firmicutes,24C48@186801|Clostridia 186801|Clostridia EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1,MFS_3 LANLAPFM_01788 622312.ROSEINA2194_01504 7.44e-216 604.0 COG1609@1|root,COG1609@2|Bacteria,1TRFH@1239|Firmicutes,24825@186801|Clostridia 186801|Clostridia K Periplasmic binding protein LacI transcriptional regulator - - 5.1.1.1 ko:K01775,ko:K02529 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011,ko03000 - - - LacI,Peripla_BP_3 LANLAPFM_01789 622312.ROSEINA2194_01505 7.74e-297 819.0 COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia 186801|Clostridia G 4-alpha-glucanotransferase malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 LANLAPFM_01790 622312.ROSEINA2194_01506 3.61e-242 674.0 COG2182@1|root,COG2182@2|Bacteria,1TPU9@1239|Firmicutes,249BY@186801|Clostridia 186801|Clostridia G ABC transporter, solute-binding protein - - - ko:K15770 ko02010,map02010 M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2 - - SBP_bac_8 LANLAPFM_01791 622312.ROSEINA2194_01507 2.3e-295 810.0 COG1175@1|root,COG1175@2|Bacteria,1TR2A@1239|Firmicutes,247MA@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K15771 ko02010,map02010 M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2 - - BPD_transp_1 LANLAPFM_01792 622312.ROSEINA2194_01508 1.62e-177 498.0 COG3833@1|root,COG3833@2|Bacteria,1TRB7@1239|Firmicutes,248A7@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K15772 ko02010,map02010 M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2 - - BPD_transp_1 LANLAPFM_01793 622312.ROSEINA2194_01509 7.26e-286 796.0 COG0366@1|root,COG0366@2|Bacteria,1TSEA@1239|Firmicutes,248HJ@186801|Clostridia 186801|Clostridia G Alpha amylase catalytic - - 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 - R02108,R02112,R11262 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3459 LANLAPFM_01794 585394.RHOM_12765 5.2e-77 237.0 2E401@1|root,32YWY@2|Bacteria,1V9X1@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - LANLAPFM_01795 1163671.JAGI01000002_gene987 5.14e-32 121.0 COG1309@1|root,COG1309@2|Bacteria,1VGKF@1239|Firmicutes,25BTR@186801|Clostridia,36JX9@31979|Clostridiaceae 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N LANLAPFM_01796 445973.CLOBAR_00493 1.52e-09 67.0 COG1033@1|root,COG1033@2|Bacteria,1VSWA@1239|Firmicutes,247R6@186801|Clostridia,25R52@186804|Peptostreptococcaceae 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K07003 - - - - ko00000 - - - MMPL LANLAPFM_01797 1507.HMPREF0262_00459 1.45e-277 774.0 COG1961@1|root,COG1961@2|Bacteria,1TPA6@1239|Firmicutes,247KF@186801|Clostridia,36DU1@31979|Clostridiaceae 186801|Clostridia L Psort location Cytoplasmic, score 7.50 - - - - - - - - - - - - DUF4368,Recombinase,Resolvase,Zn_ribbon_recom LANLAPFM_01799 1507.HMPREF0262_00461 5.16e-102 306.0 COG1475@1|root,COG1475@2|Bacteria,1TR7C@1239|Firmicutes,247TW@186801|Clostridia,36HAM@31979|Clostridiaceae 186801|Clostridia K Belongs to the ParB family - - - - - - - - - - - - ParBc LANLAPFM_01801 1203606.HMPREF1526_01052 1.13e-15 70.9 2CBNR@1|root,331FY@2|Bacteria,1VG69@1239|Firmicutes,24SAG@186801|Clostridia,36NT2@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01802 1121115.AXVN01000104_gene847 1.85e-146 419.0 COG0175@1|root,COG0175@2|Bacteria,1U1VN@1239|Firmicutes,248Y9@186801|Clostridia,3Y143@572511|Blautia 186801|Clostridia H Phosphoadenosine phosphosulfate reductase family cysD - 1.8.4.10,1.8.4.8,2.7.7.4 ko:K00390,ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R02021,R04929 RC00007,RC02809,RC02862,RC02889 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct LANLAPFM_01803 1449050.JNLE01000003_gene3109 1.42e-280 781.0 COG2895@1|root,COG2895@2|Bacteria,1UI8R@1239|Firmicutes,249BX@186801|Clostridia,36FE5@31979|Clostridiaceae 186801|Clostridia H Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily cysN - 2.7.1.25,2.7.7.4 ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 LANLAPFM_01804 585394.RHOM_02390 2.59e-201 585.0 COG2206@1|root,COG2206@2|Bacteria,1V6IE@1239|Firmicutes,24K4Y@186801|Clostridia 186801|Clostridia T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD,HD_5 LANLAPFM_01805 585394.RHOM_08220 2.1e-197 552.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia 186801|Clostridia K Periplasmic binding protein LacI transcriptional regulator ccpA - - ko:K02529,ko:K03487 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 LANLAPFM_01806 585394.RHOM_08225 0.0 877.0 COG1904@1|root,COG1904@2|Bacteria,1TRI0@1239|Firmicutes,248C0@186801|Clostridia 186801|Clostridia G glucuronate isomerase uxaC - 5.3.1.12 ko:K01812 ko00040,ko01100,map00040,map01100 M00061,M00631 R01482,R01983 RC00376 ko00000,ko00001,ko00002,ko01000 - - - UxaC LANLAPFM_01807 585394.RHOM_08230 7.83e-205 566.0 COG3717@1|root,COG3717@2|Bacteria,1TP4X@1239|Firmicutes,24A00@186801|Clostridia 186801|Clostridia G Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate kduI - 5.3.1.17 ko:K01815 ko00040,map00040 - R04383 RC00541 ko00000,ko00001,ko01000 - - - KduI LANLAPFM_01808 585394.RHOM_08235 2.22e-144 407.0 COG0698@1|root,COG0698@2|Bacteria,1TQQJ@1239|Firmicutes,249IB@186801|Clostridia 186801|Clostridia G Ribose Galactose Isomerase - - - - - - - - - - - - DUF3666,LacAB_rpiB LANLAPFM_01809 1235798.C817_02525 1.12e-08 52.0 2ERI6@1|root,33J3P@2|Bacteria,1VMBI@1239|Firmicutes,24VNP@186801|Clostridia,27VXK@189330|Dorea 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01810 585394.RHOM_08245 1.01e-81 244.0 COG3874@1|root,COG3874@2|Bacteria,1V99U@1239|Firmicutes,24K00@186801|Clostridia 186801|Clostridia S Sporulation protein YtfJ - - - - - - - - - - - - Spore_YtfJ LANLAPFM_01811 622312.ROSEINA2194_01756 1.22e-42 156.0 2E3Z2@1|root,32YW0@2|Bacteria,1VGF4@1239|Firmicutes,24PIY@186801|Clostridia 186801|Clostridia S Psort location - - - - - - - - - - - - DUF2953 LANLAPFM_01812 622312.ROSEINA2194_01757 4.77e-52 166.0 2CSSR@1|root,32SRT@2|Bacteria,1VKAJ@1239|Firmicutes,24N3Y@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_01813 585394.RHOM_08260 1.99e-94 276.0 COG1051@1|root,COG1051@2|Bacteria,1V4E6@1239|Firmicutes,24HPT@186801|Clostridia 186801|Clostridia F Belongs to the Nudix hydrolase family apfA - - - - - - - - - - - NUDIX LANLAPFM_01814 585394.RHOM_08265 1.45e-237 667.0 COG0768@1|root,COG0768@2|Bacteria,1TPER@1239|Firmicutes,2486R@186801|Clostridia 186801|Clostridia M Penicillin-binding Protein pbpA2 - - ko:K05364 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01011 - - - Transpeptidase LANLAPFM_01815 585394.RHOM_08270 5.21e-225 632.0 COG0772@1|root,COG0772@2|Bacteria,1TQ82@1239|Firmicutes,248QS@186801|Clostridia 186801|Clostridia D Belongs to the SEDS family ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FHA,FTSW_RODA_SPOVE LANLAPFM_01816 622312.ROSEINA2194_00527 5.4e-310 871.0 COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia 186801|Clostridia O peptidase U32 - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - DUF3656,Peptidase_U32 LANLAPFM_01817 585394.RHOM_08280 5.98e-60 189.0 COG3027@1|root,COG3027@2|Bacteria,1V4E5@1239|Firmicutes,24HQR@186801|Clostridia 186801|Clostridia D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA LANLAPFM_01818 585394.RHOM_08285 8.7e-215 595.0 COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia 186801|Clostridia L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N LANLAPFM_01819 622312.ROSEINA2194_00524 1.33e-111 324.0 COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,24JKV@186801|Clostridia 186801|Clostridia L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N LANLAPFM_01820 585394.RHOM_08295 3.71e-81 244.0 COG4769@1|root,COG4769@2|Bacteria,1V1M0@1239|Firmicutes,24MZC@186801|Clostridia 186801|Clostridia S Heptaprenyl diphosphate synthase component I - - 2.5.1.30 ko:K00805 ko00900,ko01110,map00900,map01110 - R09247 RC00279 ko00000,ko00001,ko01000,ko01006 - - - Hpre_diP_synt_I LANLAPFM_01821 585394.RHOM_08300 2.98e-42 144.0 COG5341@1|root,COG5341@2|Bacteria 2|Bacteria S NusG domain II - - - - - - - - - - - - NusG_II LANLAPFM_01822 585394.RHOM_08305 5.25e-303 832.0 COG0621@1|root,COG0621@2|Bacteria,1TNYN@1239|Firmicutes,2482Y@186801|Clostridia 186801|Clostridia J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 LANLAPFM_01823 585394.RHOM_08310 7.13e-238 662.0 COG0014@1|root,COG0014@2|Bacteria,1TQ9V@1239|Firmicutes,248NX@186801|Clostridia 186801|Clostridia E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh LANLAPFM_01824 622312.ROSEINA2194_00521 4.02e-47 159.0 COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,24N7H@186801|Clostridia 186801|Clostridia H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family fthC - 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig LANLAPFM_01825 585394.RHOM_08320 1.5e-31 111.0 COG4224@1|root,COG4224@2|Bacteria,1TUAX@1239|Firmicutes,24QS9@186801|Clostridia 186801|Clostridia S UPF0291 protein ynzC - - - - - - - - - - - DUF896 LANLAPFM_01826 585394.RHOM_08325 5.11e-183 511.0 COG0263@1|root,COG0263@2|Bacteria,1TPG6@1239|Firmicutes,2486P@186801|Clostridia 186801|Clostridia E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA LANLAPFM_01827 585394.RHOM_08330 1.61e-174 495.0 COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,248KJ@186801|Clostridia 186801|Clostridia H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE LANLAPFM_01828 585394.RHOM_04115 2.77e-238 663.0 COG5434@1|root,COG5434@2|Bacteria,1TRWY@1239|Firmicutes,24DY3@186801|Clostridia 186801|Clostridia M Parallel beta-helix repeats - - - - - - - - - - - - - LANLAPFM_01830 585394.RHOM_04105 1.84e-157 445.0 COG0395@1|root,COG0395@2|Bacteria,1TSGI@1239|Firmicutes,24BDH@186801|Clostridia 186801|Clostridia P binding-protein-dependent transport systems inner membrane component - - - ko:K10190 ko02010,map02010 M00199 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.4 - - BPD_transp_1 LANLAPFM_01831 585394.RHOM_04100 4.42e-144 412.0 COG1175@1|root,COG1175@2|Bacteria,1TPMR@1239|Firmicutes,2494U@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02025,ko:K10189 ko02010,map02010 M00199,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.4 - - BPD_transp_1 LANLAPFM_01832 411459.RUMOBE_02728 1.58e-193 586.0 COG4485@1|root,COG4485@2|Bacteria,1TPVY@1239|Firmicutes,24A98@186801|Clostridia,3Y056@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - YfhO LANLAPFM_01834 622312.ROSEINA2194_02532 1.79e-138 416.0 28PI9@1|root,2ZC8C@2|Bacteria,1V36K@1239|Firmicutes,24K4U@186801|Clostridia 186801|Clostridia S Glucosyl transferase GtrII - - - - - - - - - - - - Glucos_trans_II LANLAPFM_01835 585394.RHOM_06285 0.0 958.0 COG0423@1|root,COG0423@2|Bacteria,1TP94@1239|Firmicutes,248FB@186801|Clostridia 186801|Clostridia J Belongs to the class-II aminoacyl-tRNA synthetase family glyQS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - HGTP_anticodon,tRNA-synt_2b LANLAPFM_01836 585394.RHOM_06280 5.23e-86 263.0 2BFV8@1|root,329QI@2|Bacteria,1V7DP@1239|Firmicutes,24KD4@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01837 585394.RHOM_06275 1.48e-124 361.0 COG1381@1|root,COG1381@2|Bacteria,1UZ19@1239|Firmicutes,249TI@186801|Clostridia 186801|Clostridia L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N LANLAPFM_01839 622312.ROSEINA2194_02810 5.89e-203 563.0 COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,24876@186801|Clostridia 186801|Clostridia S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 LANLAPFM_01840 622312.ROSEINA2194_02811 0.0 1390.0 COG1026@1|root,COG1026@2|Bacteria,1TPD1@1239|Firmicutes 1239|Firmicutes S Peptidase M16 inactive domain protein hypA2 - - ko:K06972 - - - - ko00000,ko01000,ko01002 - - - M16C_assoc,Peptidase_M16,Peptidase_M16_C LANLAPFM_01841 585394.RHOM_06255 7.54e-40 132.0 COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,24QJE@186801|Clostridia 186801|Clostridia K Cold shock protein - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD LANLAPFM_01842 585394.RHOM_06250 2.79e-153 438.0 COG0668@1|root,COG0668@2|Bacteria,1TR9Z@1239|Firmicutes,24CAG@186801|Clostridia 186801|Clostridia M mechanosensitive ion channel mscS - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix LANLAPFM_01843 585394.RHOM_06245 2.15e-234 652.0 COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia 186801|Clostridia S Conserved protein - - - - - - - - - - - - DUF1015 LANLAPFM_01844 585394.RHOM_06240 6.8e-254 699.0 COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248H9@186801|Clostridia 186801|Clostridia EH D-isomer specific 2-hydroxyacid dehydrogenase pdxB - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C LANLAPFM_01845 585394.RHOM_06235 1.55e-255 701.0 COG1932@1|root,COG1932@2|Bacteria,1TP6Y@1239|Firmicutes,247SM@186801|Clostridia 186801|Clostridia E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 LANLAPFM_01846 622312.ROSEINA2194_02815 0.0 960.0 COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia 186801|Clostridia H Acetolactate synthase, large subunit ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N LANLAPFM_01847 585394.RHOM_06225 0.0 1073.0 COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia 186801|Clostridia EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD LANLAPFM_01848 622312.ROSEINA2194_02817 3.58e-243 670.0 COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia 186801|Clostridia C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh LANLAPFM_01850 585394.RHOM_10930 3.33e-224 625.0 COG0436@1|root,COG0436@2|Bacteria,1TP36@1239|Firmicutes,248ZV@186801|Clostridia 186801|Clostridia E Aminotransferase yhdR - 2.6.1.1 ko:K11358 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 LANLAPFM_01851 622312.ROSEINA2194_02313 5.92e-209 583.0 COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia 186801|Clostridia E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 LANLAPFM_01852 585394.RHOM_16105 4.21e-79 244.0 COG0789@1|root,COG0789@2|Bacteria,1V4F1@1239|Firmicutes,24NFY@186801|Clostridia 186801|Clostridia K transcriptional regulator, MerR family - - - - - - - - - - - - MerR_1 LANLAPFM_01854 742722.HMPREF9463_01777 4.22e-18 79.3 COG1669@1|root,COG1669@2|Bacteria,2HVIG@201174|Actinobacteria,4CWW6@84998|Coriobacteriia 84998|Coriobacteriia S Nucleotidyltransferase domain - - - - - - - - - - - - NTP_transf_2 LANLAPFM_01855 1235790.C805_00736 5.17e-34 118.0 COG3655@1|root,COG3655@2|Bacteria 2|Bacteria K Transcriptional regulator - - - - - - - - - - - - DUF4384,HTH_26,HTH_3 LANLAPFM_01860 476272.RUMHYD_01896 3.4e-64 206.0 2C08P@1|root,2ZC0W@2|Bacteria,1V1N6@1239|Firmicutes,24H70@186801|Clostridia,3Y1ZW@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF4417 LANLAPFM_01861 658655.HMPREF0988_00914 2.68e-40 136.0 2BDGD@1|root,3275I@2|Bacteria,1UT1G@1239|Firmicutes,25IPX@186801|Clostridia,27SI5@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01862 97139.C824_03355 9.33e-37 134.0 COG3646@1|root,COG3646@2|Bacteria 2|Bacteria L Phage regulatory protein - - - ko:K07741 - - - - ko00000 - - - ANT,ORF6C,Phage_pRha LANLAPFM_01865 585394.RHOM_09340 1.85e-184 523.0 COG1073@1|root,COG1073@2|Bacteria,1UF81@1239|Firmicutes,24BZ7@186801|Clostridia 186801|Clostridia H Protein of unknown function (DUF2974) - - - - - - - - - - - - DUF2974 LANLAPFM_01866 622312.ROSEINA2194_01364 4.65e-112 330.0 COG0561@1|root,COG0561@2|Bacteria,1TSZZ@1239|Firmicutes,25B6T@186801|Clostridia 186801|Clostridia S Sucrose-6F-phosphate phosphohydrolase - - - - - - - - - - - - Hydrolase_3 LANLAPFM_01867 585394.RHOM_09350 1.33e-299 823.0 COG1143@1|root,COG4624@1|root,COG1143@2|Bacteria,COG4624@2|Bacteria,1TQIR@1239|Firmicutes,248BS@186801|Clostridia 186801|Clostridia C Iron only hydrogenase large subunit, C-terminal domain - - 1.12.7.2 ko:K00533 - - R00019 - ko00000,ko01000 - - - Fe_hyd_lg_C,Fer4 LANLAPFM_01868 483218.BACPEC_02951 3.94e-126 374.0 COG2199@1|root,COG2199@2|Bacteria,1VBH6@1239|Firmicutes,24P8P@186801|Clostridia 186801|Clostridia T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF LANLAPFM_01869 483218.BACPEC_02952 1.9e-84 264.0 COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,249J1@186801|Clostridia,26BFC@186813|unclassified Clostridiales 186801|Clostridia S Serine hydrolase (FSH1) - - - ko:K06889 - - - - ko00000 - - - FSH1,Hydrolase_4,Peptidase_S9 LANLAPFM_01870 622312.ROSEINA2194_02134 1.14e-37 148.0 2CB93@1|root,30P4I@2|Bacteria,1V581@1239|Firmicutes,24IR0@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01871 585394.RHOM_10175 0.0 1105.0 COG2217@1|root,COG2217@2|Bacteria,1TPB8@1239|Firmicutes,247RZ@186801|Clostridia 186801|Clostridia P heavy metal translocating P-type ATPase copA_1 - - ko:K12950 - - - - ko00000,ko01000 3.A.3.32 - - E1-E2_ATPase,Hydrolase LANLAPFM_01872 411902.CLOBOL_05591 2.48e-34 121.0 2E5VW@1|root,330JY@2|Bacteria,1VEZ5@1239|Firmicutes,24R14@186801|Clostridia,2218J@1506553|Lachnoclostridium 186801|Clostridia S H( )-transporting two-sector ATPase subunit H.a (A-type ATP synthase) K02121 - - - - - - - - - - - - - LANLAPFM_01873 622312.ROSEINA2194_01772 0.0 972.0 COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,248EH@186801|Clostridia 186801|Clostridia P ATPase, P-type (transporting), HAD superfamily, subfamily IC cadA - 3.6.3.3,3.6.3.5 ko:K01534 - - - - ko00000,ko01000 3.A.3.6 - - E1-E2_ATPase,HMA,Hydrolase LANLAPFM_01874 585394.RHOM_03480 3.73e-40 133.0 COG2608@1|root,COG2608@2|Bacteria,1VEM6@1239|Firmicutes,24R22@186801|Clostridia 186801|Clostridia P Heavy metal-associated domain protein - - - - - - - - - - - - HMA LANLAPFM_01875 622312.ROSEINA2194_01770 1.55e-65 201.0 COG0640@1|root,COG0640@2|Bacteria,1VA6G@1239|Firmicutes,24JCN@186801|Clostridia 186801|Clostridia K transcriptional regulator ziaR - - ko:K21903 - - - - ko00000,ko03000 - - - HTH_5 LANLAPFM_01876 903814.ELI_3973 4.26e-89 271.0 COG0300@1|root,COG0300@2|Bacteria,1V3UX@1239|Firmicutes,25B0Y@186801|Clostridia,25WEG@186806|Eubacteriaceae 186801|Clostridia S Enoyl-(Acyl carrier protein) reductase - - - ko:K07124 - - - - ko00000 - - - adh_short LANLAPFM_01877 622312.ROSEINA2194_02492 2.1e-172 484.0 COG0395@1|root,COG0395@2|Bacteria,1TS0R@1239|Firmicutes,248UX@186801|Clostridia 186801|Clostridia P ABC-type sugar transport system, permease component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 LANLAPFM_01878 622312.ROSEINA2194_02493 2.03e-193 540.0 COG1175@1|root,COG1175@2|Bacteria,1TS63@1239|Firmicutes,2489M@186801|Clostridia 186801|Clostridia G ABC-type sugar transport systems permease components - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 LANLAPFM_01879 622312.ROSEINA2194_02494 3.37e-258 717.0 COG1653@1|root,COG1653@2|Bacteria,1TRPJ@1239|Firmicutes,24872@186801|Clostridia 186801|Clostridia G ABC-type sugar transport system periplasmic component - - - - - - - - - - - - SBP_bac_8 LANLAPFM_01880 585394.RHOM_05815 1.83e-153 433.0 COG2207@1|root,COG2207@2|Bacteria,1UZ5U@1239|Firmicutes,24DJM@186801|Clostridia 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,HTH_AraC LANLAPFM_01881 658088.HMPREF0987_01443 0.0 1325.0 COG3459@1|root,COG3459@2|Bacteria,1UYFP@1239|Firmicutes,24A8A@186801|Clostridia,27J08@186928|unclassified Lachnospiraceae 186801|Clostridia G Glycosyl hydrolase 36 superfamily, catalytic domain - - - - - - - - - - - - Glyco_hydro_36,Glyco_transf_36 LANLAPFM_01882 658088.HMPREF0987_01444 0.0 1464.0 COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia,27I5Y@186928|unclassified Lachnospiraceae 186801|Clostridia G Putative carbohydrate binding domain - - - - - - - - - - - - Glyco_hydro_36,Glyco_transf_36 LANLAPFM_01883 585394.RHOM_03735 6.56e-293 799.0 COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia 186801|Clostridia C alcohol dehydrogenase adh - - - - - - - - - - - Fe-ADH LANLAPFM_01884 397288.C806_01857 1.17e-34 151.0 COG3209@1|root,COG3209@2|Bacteria,1UJWP@1239|Firmicutes,25FCF@186801|Clostridia,27T8Y@186928|unclassified Lachnospiraceae 186801|Clostridia M Listeria-Bacteroides repeat domain (List_Bact_rpt) - - - - - - - - - - - - Flg_new LANLAPFM_01885 585394.RHOM_02385 0.0 1014.0 COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,247WQ@186801|Clostridia 186801|Clostridia O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 LANLAPFM_01886 585394.RHOM_02380 9.54e-101 294.0 COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia 186801|Clostridia F Belongs to the purine pyrimidine phosphoribosyltransferase family hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran LANLAPFM_01887 585394.RHOM_02375 1.61e-161 473.0 COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia 186801|Clostridia D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C LANLAPFM_01888 622312.ROSEINA2194_01491 7.74e-307 852.0 COG2208@1|root,COG2208@2|Bacteria,1TQ92@1239|Firmicutes,247XG@186801|Clostridia 186801|Clostridia KT stage ii sporulation protein e spoIIE - 3.1.3.16 ko:K06382 - - - - ko00000,ko01000 - - - SpoIIE LANLAPFM_01889 622312.ROSEINA2194_01490 3.75e-213 592.0 COG0667@1|root,COG0667@2|Bacteria,1TRS0@1239|Firmicutes,247RJ@186801|Clostridia 186801|Clostridia C aldo keto reductase - - - ko:K19265 - - - - ko00000,ko01000 - - - Aldo_ket_red LANLAPFM_01890 622312.ROSEINA2194_01489 1.68e-33 118.0 COG2919@1|root,COG2919@2|Bacteria,1VGPP@1239|Firmicutes,24R6M@186801|Clostridia 186801|Clostridia D septum formation initiator - - - - - - - - - - - - DivIC LANLAPFM_01891 622312.ROSEINA2194_01488 1.13e-53 173.0 2EFTM@1|root,32YR5@2|Bacteria,1VEV2@1239|Firmicutes 1239|Firmicutes S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Spore_YabQ LANLAPFM_01892 622312.ROSEINA2194_01487 1.24e-51 164.0 2E3ZZ@1|root,32YWW@2|Bacteria,1VEIW@1239|Firmicutes,24QNQ@186801|Clostridia 186801|Clostridia S Sporulation protein YabP yabP - - - - - - - - - - - YabP LANLAPFM_01893 585394.RHOM_02340 2.46e-44 144.0 COG1188@1|root,COG1188@2|Bacteria,1VEI5@1239|Firmicutes,24QNF@186801|Clostridia 186801|Clostridia J S4 domain protein hslR - - - - - - - - - - - S4 LANLAPFM_01894 622312.ROSEINA2194_01485 1.04e-50 161.0 COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,24MM0@186801|Clostridia 186801|Clostridia L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hup - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding LANLAPFM_01896 622312.ROSEINA2194_01484 0.0 1046.0 COG1109@1|root,COG1109@2|Bacteria,1TP2N@1239|Firmicutes,2481Y@186801|Clostridia 186801|Clostridia G phosphoglucomutase phosphomannomutase alpha beta alpha domain II pgcA - 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV LANLAPFM_01897 585394.RHOM_02320 8.39e-137 409.0 28JT6@1|root,2Z9II@2|Bacteria,1V7ZW@1239|Firmicutes,24H3G@186801|Clostridia 186801|Clostridia S PEGA domain - - - - - - - - - - - - PEGA LANLAPFM_01898 585394.RHOM_02315 1.41e-144 417.0 COG2334@1|root,COG2334@2|Bacteria,1TTBS@1239|Firmicutes,2483F@186801|Clostridia 186801|Clostridia S spore coat protein, CotS cotS - - ko:K06331,ko:K06337 - - - - ko00000 - - - APH,Choline_kinase LANLAPFM_01899 622312.ROSEINA2194_01481 1.05e-243 678.0 COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia 186801|Clostridia J tRNA nucleotidyltransferase poly(A) polymerase cca - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 - - - HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 LANLAPFM_01900 397291.C804_00766 2.56e-231 697.0 COG0457@1|root,COG2199@1|root,COG0457@2|Bacteria,COG2199@2|Bacteria,1VQTU@1239|Firmicutes,24D8M@186801|Clostridia 186801|Clostridia T Diguanylate cyclase (GGDEF) domain - - - - - - - - - - - - GGDEF LANLAPFM_01901 585394.RHOM_02305 0.0 909.0 COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,249PY@186801|Clostridia 186801|Clostridia J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b LANLAPFM_01902 622312.ROSEINA2194_01477 1.04e-110 323.0 COG0564@1|root,COG0564@2|Bacteria,1TX59@1239|Firmicutes,24HTV@186801|Clostridia 186801|Clostridia J Pseudouridine synthase - - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 LANLAPFM_01903 585394.RHOM_02290 3.14e-26 99.0 28TG6@1|root,2ZFQ4@2|Bacteria,1W51P@1239|Firmicutes,2575E@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01904 585394.RHOM_02285 5.2e-156 438.0 COG0745@1|root,COG0745@2|Bacteria,1TPRU@1239|Firmicutes,24843@186801|Clostridia 186801|Clostridia KT response regulator receiver srrA_2 - - - - - - - - - - - Response_reg,Trans_reg_C LANLAPFM_01905 585394.RHOM_02280 1.1e-277 769.0 COG3850@1|root,COG5002@1|root,COG3850@2|Bacteria,COG5002@2|Bacteria,1TPVJ@1239|Firmicutes,2489X@186801|Clostridia 186801|Clostridia T Histidine kinase- DNA gyrase B yycG_1 - - - - - - - - - - - HAMP,HATPase_c,HisKA LANLAPFM_01906 1121115.AXVN01000012_gene3113 1.12e-188 528.0 COG3940@1|root,COG3940@2|Bacteria,1TRHI@1239|Firmicutes,24AG6@186801|Clostridia,3Y1H0@572511|Blautia 186801|Clostridia G Glycosyl hydrolases family 43 - - - - - - - - - - - - Glyco_hydro_43 LANLAPFM_01907 140626.JHWB01000013_gene760 1.74e-293 809.0 COG3534@1|root,COG3534@2|Bacteria,1TR7B@1239|Firmicutes,248ZA@186801|Clostridia 186801|Clostridia G Alpha-L-arabinofuranosidase - - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C LANLAPFM_01908 1280688.AUJB01000008_gene632 5.67e-30 108.0 2DPI5@1|root,3326E@2|Bacteria,1VIQZ@1239|Firmicutes,24UPV@186801|Clostridia,3NIA5@46205|Pseudobutyrivibrio 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01909 1410625.JHWK01000005_gene1207 2.55e-170 481.0 COG4189@1|root,COG4189@2|Bacteria,1TPGD@1239|Firmicutes,248UW@186801|Clostridia,27K27@186928|unclassified Lachnospiraceae 186801|Clostridia K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_24 LANLAPFM_01910 622312.ROSEINA2194_02152 2e-61 192.0 COG0622@1|root,COG0622@2|Bacteria,1V7VB@1239|Firmicutes,24PEZ@186801|Clostridia 186801|Clostridia S Phosphoesterase - - - ko:K07095 - - - - ko00000 - - - Metallophos_2 LANLAPFM_01911 1235790.C805_03587 1.54e-117 356.0 COG2340@1|root,COG2340@2|Bacteria,1V1IM@1239|Firmicutes,24GB5@186801|Clostridia,25WC7@186806|Eubacteriaceae 186801|Clostridia N hydrolase, family 25 - - - - - - - - - - - - CAP,SLH LANLAPFM_01912 585394.RHOM_14040 3.88e-42 139.0 2C5I7@1|root,330HE@2|Bacteria,1VJU8@1239|Firmicutes,24SCX@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.75 - - - - - - - - - - - - DUF4321 LANLAPFM_01913 585394.RHOM_02665 8.93e-164 462.0 COG3833@1|root,COG3833@2|Bacteria,1TRB7@1239|Firmicutes,24DNI@186801|Clostridia 186801|Clostridia G PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K15772 ko02010,map02010 M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2 - - BPD_transp_1 LANLAPFM_01914 585394.RHOM_02660 1.78e-33 126.0 COG1175@1|root,COG1175@2|Bacteria,1TR2A@1239|Firmicutes,247MA@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K15771 ko02010,map02010 M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2 - - BPD_transp_1 LANLAPFM_01915 1256908.HMPREF0373_03376 9.56e-75 225.0 COG5658@1|root,COG5658@2|Bacteria,1VB6E@1239|Firmicutes,24MSY@186801|Clostridia,25XHU@186806|Eubacteriaceae 186801|Clostridia S SdpI/YhfL protein family - - - - - - - - - - - - SdpI LANLAPFM_01916 1469948.JPNB01000002_gene2779 1.89e-113 330.0 COG1272@1|root,COG1272@2|Bacteria,1TSFK@1239|Firmicutes,24CPT@186801|Clostridia,36HYG@31979|Clostridiaceae 186801|Clostridia S channel protein, hemolysin III family yqfA - - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII LANLAPFM_01917 585394.RHOM_11750 6.75e-163 461.0 COG2017@1|root,COG2017@2|Bacteria,1U26T@1239|Firmicutes,24AQ8@186801|Clostridia 186801|Clostridia G Aldose 1-epimerase lacX - - - - - - - - - - - Aldose_epim LANLAPFM_01918 585394.RHOM_11745 3.9e-41 140.0 2E3KV@1|root,32YJ5@2|Bacteria,1VEHD@1239|Firmicutes,24RP3@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - DUF3792 LANLAPFM_01919 476272.RUMHYD_00772 4.26e-267 739.0 COG2233@1|root,COG2233@2|Bacteria,1TNZZ@1239|Firmicutes,25CEM@186801|Clostridia,3XYP4@572511|Blautia 186801|Clostridia F Psort location CytoplasmicMembrane, score 10.00 pbuX - - ko:K03458 - - - - ko00000 2.A.40 - - Xan_ur_permease LANLAPFM_01920 1256908.HMPREF0373_02435 7.28e-20 80.9 2EGRK@1|root,33AHS@2|Bacteria,1VK9R@1239|Firmicutes,24UM0@186801|Clostridia,25XQV@186806|Eubacteriaceae 186801|Clostridia S Six-cysteine peptide SCIFF scfA - - - - - - - - - - - SCIFF LANLAPFM_01921 585394.RHOM_14400 1.41e-97 285.0 COG0590@1|root,COG0590@2|Bacteria,1V3HZ@1239|Firmicutes,24JM2@186801|Clostridia 186801|Clostridia FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam LANLAPFM_01922 585394.RHOM_14405 1.02e-76 235.0 COG1670@1|root,COG1670@2|Bacteria,1V1ZC@1239|Firmicutes,249K2@186801|Clostridia 186801|Clostridia J Acetyltransferase GNAT family - - 2.3.1.128 ko:K03790 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 LANLAPFM_01923 622312.ROSEINA2194_01957 5.24e-92 285.0 2BZEU@1|root,30VT8@2|Bacteria,1V54M@1239|Firmicutes,24SSI@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_01924 585394.RHOM_13060 6.08e-79 259.0 COG2199@1|root,COG2199@2|Bacteria,1V0N3@1239|Firmicutes,24FMU@186801|Clostridia 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - 7TMR-DISM_7TM,GGDEF,SBP_bac_3 LANLAPFM_01926 411463.EUBVEN_02080 2.3e-195 551.0 COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,248AY@186801|Clostridia,25UZ8@186806|Eubacteriaceae 186801|Clostridia E Aminotransferase, class I patB - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 LANLAPFM_01927 411463.EUBVEN_02011 2.24e-159 449.0 COG0708@1|root,COG0708@2|Bacteria,1TPFB@1239|Firmicutes,24849@186801|Clostridia,25V2W@186806|Eubacteriaceae 186801|Clostridia L exodeoxyribonuclease III xth - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos LANLAPFM_01929 622312.ROSEINA2194_02797 8.71e-123 379.0 COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia 186801|Clostridia C 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - - DUF4445,Fer2 LANLAPFM_01930 1410626.JHXB01000003_gene1076 0.000519 45.1 COG5492@1|root,COG5492@2|Bacteria 2|Bacteria N domain, Protein ligA1 - - - - - - - - - - - Big_2,DUF3494 LANLAPFM_01931 397291.C804_02849 6.5e-88 268.0 COG2310@1|root,COG2310@2|Bacteria,1V26C@1239|Firmicutes,24GMA@186801|Clostridia,27N1D@186928|unclassified Lachnospiraceae 186801|Clostridia T TerD domain - - - - - - - - - - - - TerD LANLAPFM_01932 575593.HMPREF0491_01365 2.22e-130 374.0 COG2013@1|root,COG2013@2|Bacteria,1TSVH@1239|Firmicutes,24DQR@186801|Clostridia,27JVP@186928|unclassified Lachnospiraceae 186801|Clostridia S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24 LANLAPFM_01933 1235799.C818_01135 2.84e-94 285.0 COG0561@1|root,COG0561@2|Bacteria,1V24C@1239|Firmicutes,24HGT@186801|Clostridia,27N1C@186928|unclassified Lachnospiraceae 186801|Clostridia S hydrolases of the HAD superfamily - - - - - - - - - - - - Hydrolase_3,S6PP LANLAPFM_01934 1121115.AXVN01000018_gene51 0.0 1407.0 COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,3XZ0A@572511|Blautia 186801|Clostridia P Cation transporter/ATPase, N-terminus - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 LANLAPFM_01935 1121115.AXVN01000018_gene50 5.68e-113 327.0 COG2310@1|root,COG2310@2|Bacteria,1TR98@1239|Firmicutes,24FZM@186801|Clostridia,3Y13G@572511|Blautia 186801|Clostridia T TerD domain yceC - - - - - - - - - - - TerD LANLAPFM_01936 397291.C804_02843 1.4e-124 356.0 COG2310@1|root,COG2310@2|Bacteria,1TNZQ@1239|Firmicutes,24A3Y@186801|Clostridia,27K57@186928|unclassified Lachnospiraceae 186801|Clostridia T TerD domain terD_2 - - ko:K05795 - - - - ko00000 - - - TerD LANLAPFM_01937 1121115.AXVN01000018_gene47 1.07e-207 582.0 COG3853@1|root,COG3853@2|Bacteria,1TQVX@1239|Firmicutes,24A2H@186801|Clostridia,3Y1EX@572511|Blautia 186801|Clostridia P Toxic anion resistance protein (TelA) - - - - - - - - - - - - TelA LANLAPFM_01938 1121115.AXVN01000018_gene46 0.0 1170.0 2BVVP@1|root,2Z9CR@2|Bacteria,1TRYC@1239|Firmicutes,2487Q@186801|Clostridia,3Y1D8@572511|Blautia 186801|Clostridia S Putative component of 'biosynthetic module' - - - - - - - - - - - - YceG_bac LANLAPFM_01939 397288.C806_01988 9.57e-99 291.0 COG0705@1|root,COG0705@2|Bacteria,1V1C3@1239|Firmicutes,24GPR@186801|Clostridia,27KQ7@186928|unclassified Lachnospiraceae 186801|Clostridia S Rhomboid family - - - ko:K02441 - - - - ko00000 - - - Rhomboid LANLAPFM_01940 457412.RSAG_01637 1.3e-169 480.0 COG2301@1|root,COG2301@2|Bacteria,1TSF2@1239|Firmicutes,249TC@186801|Clostridia,3WJ19@541000|Ruminococcaceae 186801|Clostridia G C-C_Bond_Lyase of the TIM-Barrel fold - - - - - - - - - - - - C-C_Bond_Lyase LANLAPFM_01942 457412.RSAG_01638 1.58e-201 563.0 COG1358@1|root,COG1358@2|Bacteria,1TP5Y@1239|Firmicutes,2487J@186801|Clostridia,3WH6S@541000|Ruminococcaceae 186801|Clostridia J PELOTA RNA binding domain - - - - - - - - - - - - PELOTA_1,PRTase_1,PRTase_2,TRSP LANLAPFM_01943 1121115.AXVN01000018_gene43 4.37e-150 435.0 COG0503@1|root,COG0503@2|Bacteria,1UZSF@1239|Firmicutes,24FUM@186801|Clostridia,3Y1E0@572511|Blautia 186801|Clostridia F Phosphoribosyl transferase - - - - - - - - - - - - PRTase_2,TRSP LANLAPFM_01944 97139.C824_03803 3.73e-86 268.0 28M3R@1|root,32UZU@2|Bacteria,1VBVW@1239|Firmicutes,24J58@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01945 585394.RHOM_13220 0.0 1054.0 COG0659@1|root,COG0659@2|Bacteria,1TPI4@1239|Firmicutes,24978@186801|Clostridia 186801|Clostridia P Sulfate transporter sulP - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp LANLAPFM_01946 411462.DORLON_02338 6.14e-296 809.0 COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,247XK@186801|Clostridia,27UZZ@189330|Dorea 186801|Clostridia H Cys/Met metabolism PLP-dependent enzyme metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP LANLAPFM_01947 622312.ROSEINA2194_03515 5.12e-129 396.0 COG2200@1|root,COG2200@2|Bacteria,1TS8B@1239|Firmicutes,24EZ4@186801|Clostridia 186801|Clostridia T GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_9 LANLAPFM_01948 1280694.AUJQ01000020_gene6 1.81e-55 178.0 COG0663@1|root,COG0663@2|Bacteria,1V6CZ@1239|Firmicutes,24JAK@186801|Clostridia 186801|Clostridia C Bacterial transferase hexapeptide PaaY - - ko:K02617 - - - - ko00000 - - - Hexapep,Hexapep_2 LANLAPFM_01949 411474.COPEUT_00684 2.57e-79 241.0 COG1102@1|root,COG1102@2|Bacteria,1V4ZA@1239|Firmicutes 1239|Firmicutes F Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Cytidylate_kin2 LANLAPFM_01950 883109.HMPREF0380_01476 4.4e-62 192.0 COG1393@1|root,COG1393@2|Bacteria,1VA5Q@1239|Firmicutes,24JGY@186801|Clostridia,3WDDV@538999|Clostridiales incertae sedis 186801|Clostridia P ArsC family spxA - 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC,Glutaredoxin LANLAPFM_01951 585394.RHOM_08575 3.91e-310 868.0 COG0840@1|root,COG0840@2|Bacteria,1UYFA@1239|Firmicutes,24F3M@186801|Clostridia 186801|Clostridia NT PilZ domain - - - - - - - - - - - - MCPsignal,PilZ LANLAPFM_01952 622312.ROSEINA2194_01478 7.6e-201 582.0 COG0840@1|root,COG4564@1|root,COG0840@2|Bacteria,COG4564@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia 186801|Clostridia NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,dCache_1,sCache_2 LANLAPFM_01953 1226325.HMPREF1548_05939 6.25e-36 122.0 COG1918@1|root,COG1918@2|Bacteria,1VEYA@1239|Firmicutes,24QKX@186801|Clostridia,36MP8@31979|Clostridiaceae 186801|Clostridia P Fe2 transport system protein A - - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA LANLAPFM_01954 585394.RHOM_03450 7.15e-43 140.0 COG1918@1|root,COG1918@2|Bacteria,1VEHC@1239|Firmicutes,24QKE@186801|Clostridia 186801|Clostridia P Fe2 transport system protein A feoA - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA LANLAPFM_01955 585394.RHOM_03455 0.0 1303.0 COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia 186801|Clostridia P transporter of a GTP-driven Fe(2 ) uptake system feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate LANLAPFM_01956 1235799.C818_03332 7.94e-17 72.4 2C6KI@1|root,33J10@2|Bacteria,1VKBK@1239|Firmicutes,24UUY@186801|Clostridia,27Q8P@186928|unclassified Lachnospiraceae 186801|Clostridia S Virus attachment protein p12 family - - - - - - - - - - - - P12 LANLAPFM_01957 1304866.K413DRAFT_2073 2.45e-66 206.0 COG0735@1|root,COG0735@2|Bacteria,1V6DP@1239|Firmicutes,24K9H@186801|Clostridia,36IEH@31979|Clostridiaceae 186801|Clostridia P Belongs to the Fur family fur - - ko:K03711 - - - - ko00000,ko03000 - - - FUR LANLAPFM_01958 585394.RHOM_10590 1.02e-34 120.0 COG2608@1|root,COG2608@2|Bacteria,1VETC@1239|Firmicutes,24QJU@186801|Clostridia 186801|Clostridia P mercury ion transmembrane transporter activity - - - - - - - - - - - - HMA LANLAPFM_01959 622312.ROSEINA2194_04430 3.22e-63 204.0 2DMJ6@1|root,32RY3@2|Bacteria,1VBBI@1239|Firmicutes,24N5I@186801|Clostridia 186801|Clostridia S Colicin V production protein - - - - - - - - - - - - Colicin_V LANLAPFM_01960 585394.RHOM_14305 1.49e-186 530.0 2C3W5@1|root,2ZBIU@2|Bacteria,1UZRE@1239|Firmicutes,24BHB@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - LANLAPFM_01961 622312.ROSEINA2194_04432 7.8e-105 328.0 COG1652@1|root,COG1652@2|Bacteria,1UIP6@1239|Firmicutes,25EPX@186801|Clostridia 186801|Clostridia S Lysin motif - - - - - - - - - - - - LysM LANLAPFM_01962 622312.ROSEINA2194_04433 1.83e-207 575.0 COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia 186801|Clostridia G Transketolase tktB - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C LANLAPFM_01963 585394.RHOM_14320 5.03e-192 533.0 COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia 186801|Clostridia G Transketolase, thiamine diphosphate binding domain tktA - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N LANLAPFM_01964 622312.ROSEINA2194_04435 1.86e-129 369.0 COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia 186801|Clostridia L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - HHH,RecR,Toprim_4 LANLAPFM_01965 180332.JTGN01000005_gene2749 3.05e-19 79.0 2EIM1@1|root,33CCB@2|Bacteria,1VM79@1239|Firmicutes,24UNI@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01966 622312.ROSEINA2194_00446 0.0 1226.0 COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia 186801|Clostridia P ATPase, P-type (transporting), HAD superfamily, subfamily IC actP - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase LANLAPFM_01967 622312.ROSEINA2194_00445 9.87e-54 171.0 COG1937@1|root,COG1937@2|Bacteria,1VEF5@1239|Firmicutes,24QRR@186801|Clostridia 186801|Clostridia S PFAM Uncharacterised BCR, COG1937 csoR - - ko:K21600 - - - - ko00000,ko03000 - - - Trns_repr_metal LANLAPFM_01968 622312.ROSEINA2194_02915 1.05e-245 682.0 COG0534@1|root,COG0534@2|Bacteria,1TP6V@1239|Firmicutes,248EF@186801|Clostridia 186801|Clostridia V MATE efflux family protein - - - - - - - - - - - - MatE LANLAPFM_01969 1410628.JNKS01000004_gene2041 8.11e-73 219.0 COG3654@1|root,COG3654@2|Bacteria,1V6EG@1239|Firmicutes,24J85@186801|Clostridia,27NM5@186928|unclassified Lachnospiraceae 186801|Clostridia S TIGRFAM death-on-curing family protein - - - ko:K07341 - - - - ko00000,ko02048 - - - Fic LANLAPFM_01970 936574.HMPREF1508_1331 7.94e-41 135.0 2E4DC@1|root,32Z8R@2|Bacteria,1VF6A@1239|Firmicutes,24QX7@186801|Clostridia 186801|Clostridia S Antitoxin component of a toxin-antitoxin (TA) module - - - ko:K19165 - - - - ko00000,ko02048 - - - PhdYeFM_antitox LANLAPFM_01971 411469.EUBHAL_03045 4.2e-68 209.0 COG0716@1|root,COG0716@2|Bacteria,1V6D7@1239|Firmicutes,24J7W@186801|Clostridia,25WIN@186806|Eubacteriaceae 186801|Clostridia C flavodoxin - - - - - - - - - - - - Flavodoxin_1 LANLAPFM_01972 457421.CBFG_05476 1.85e-59 192.0 2BYWB@1|root,32SGE@2|Bacteria,1VAZ2@1239|Firmicutes,24J86@186801|Clostridia,269B4@186813|unclassified Clostridiales 186801|Clostridia S Protein of unknown function (DUF3793) - - - - - - - - - - - - DUF3793 LANLAPFM_01973 585394.RHOM_14370 1.8e-133 383.0 COG2357@1|root,COG2357@2|Bacteria 2|Bacteria S guanosine tetraphosphate metabolic process - - 2.7.6.5 ko:K07816 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - RelA_SpoT LANLAPFM_01974 622312.ROSEINA2194_01965 1.25e-252 697.0 COG4284@1|root,COG4284@2|Bacteria,1TQUD@1239|Firmicutes,24A8D@186801|Clostridia 186801|Clostridia G Psort location Cytoplasmic, score - - 2.7.7.23,2.7.7.83 ko:K00972 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00361,M00362 R00416 RC00002 ko00000,ko00001,ko00002,ko01000 - - - UDPGP LANLAPFM_01975 585394.RHOM_14380 1.04e-173 488.0 COG1284@1|root,COG1284@2|Bacteria,1TR9J@1239|Firmicutes,24BGW@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF2179,YitT_membrane LANLAPFM_01976 742765.HMPREF9457_00411 5.49e-147 466.0 COG0642@1|root,COG0784@1|root,COG0642@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,27WC0@189330|Dorea 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg,SBP_bac_3 LANLAPFM_01977 742765.HMPREF9457_00412 5.72e-86 266.0 COG0834@1|root,COG0834@2|Bacteria,1VTCR@1239|Firmicutes,24YIS@186801|Clostridia,27WVQ@189330|Dorea 186801|Clostridia ET Bacterial periplasmic substrate-binding proteins - - - - - - - - - - - - SBP_bac_3 LANLAPFM_01978 1408306.JHXX01000003_gene1416 3.16e-126 360.0 COG2316@1|root,COG2316@2|Bacteria,1TSF7@1239|Firmicutes,24A1B@186801|Clostridia,4BY0F@830|Butyrivibrio 186801|Clostridia S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD LANLAPFM_01979 1226325.HMPREF1548_03034 4.37e-38 141.0 2C2T8@1|root,32RB0@2|Bacteria,1V8YX@1239|Firmicutes,24M80@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01980 585394.RHOM_06140 3.49e-307 878.0 28J8A@1|root,2Z93H@2|Bacteria,1UYEZ@1239|Firmicutes,24AV4@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01981 411469.EUBHAL_02516 4.24e-178 504.0 COG0438@1|root,COG0438@2|Bacteria,1TPG9@1239|Firmicutes,24EAP@186801|Clostridia,25WEJ@186806|Eubacteriaceae 186801|Clostridia M Stealth protein CR2, conserved region 2 - - - - - - - - - - - - Stealth_CR1,Stealth_CR2,Stealth_CR3,Stealth_CR4 LANLAPFM_01982 1280698.AUJS01000004_gene2938 3.24e-238 661.0 COG0502@1|root,COG0502@2|Bacteria,1TPEX@1239|Firmicutes,248PF@186801|Clostridia,27URQ@189330|Dorea 186801|Clostridia C Biotin and Thiamin Synthesis associated domain thiH - 4.1.99.19 ko:K03150 ko00730,ko01100,map00730,map01100 - R10246 RC01434,RC03095 ko00000,ko00001,ko01000 - - - BATS,Radical_SAM LANLAPFM_01983 411459.RUMOBE_00194 1.68e-68 215.0 COG0352@1|root,COG0352@2|Bacteria,1V4SE@1239|Firmicutes,24JTR@186801|Clostridia,3Y00P@572511|Blautia 186801|Clostridia H Thiamine monophosphate synthase tenI - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS06600 TMP-TENI LANLAPFM_01984 622312.ROSEINA2194_02259 1.67e-80 249.0 COG0850@1|root,COG0850@2|Bacteria,1VAPC@1239|Firmicutes,24MV1@186801|Clostridia 186801|Clostridia D Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization minC - - ko:K03610 - - - - ko00000,ko03036,ko04812 - - - MinC_C LANLAPFM_01985 622312.ROSEINA2194_02260 2.91e-158 447.0 COG2894@1|root,COG2894@2|Bacteria,1TP6P@1239|Firmicutes,249BB@186801|Clostridia 186801|Clostridia D Belongs to the ParA family minD - - ko:K03609 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA LANLAPFM_01986 658086.HMPREF0994_01119 3.93e-46 149.0 COG0851@1|root,COG0851@2|Bacteria,1VFST@1239|Firmicutes,24QT6@186801|Clostridia,27NQT@186928|unclassified Lachnospiraceae 186801|Clostridia D Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell minE - - ko:K03608 - - - - ko00000,ko03036,ko04812 - - - MinE LANLAPFM_01987 1235790.C805_00155 1.41e-176 496.0 COG1396@1|root,COG1396@2|Bacteria,1VF0W@1239|Firmicutes,24R43@186801|Clostridia,25XCU@186806|Eubacteriaceae 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 LANLAPFM_01988 585394.RHOM_05665 1.96e-38 140.0 COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia 186801|Clostridia L PFAM transposase, mutator - - - ko:K07493 - - - - ko00000 - - - Transposase_mut LANLAPFM_01989 1121115.AXVN01000132_gene727 1.91e-13 67.0 2CUHA@1|root,30KV1@2|Bacteria,1V52Z@1239|Firmicutes,24I1N@186801|Clostridia,3Y1IQ@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01990 585394.RHOM_11645 7.05e-280 774.0 COG0635@1|root,COG0635@2|Bacteria,1TREM@1239|Firmicutes,247JT@186801|Clostridia 186801|Clostridia H coproporphyrinogen hemZ - - - - - - - - - - - Radical_SAM LANLAPFM_01991 585394.RHOM_11650 1.11e-122 352.0 COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,24JGV@186801|Clostridia 186801|Clostridia P domain protein - - - - - - - - - - - - Lactamase_B LANLAPFM_01992 622312.ROSEINA2194_02168 0.0 1385.0 COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia 186801|Clostridia KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS16615 ACT_4,HD_4,RelA_SpoT,TGS LANLAPFM_01993 585394.RHOM_11660 1.99e-79 250.0 COG1670@1|root,COG1670@2|Bacteria,1V4FZ@1239|Firmicutes,24PF4@186801|Clostridia 186801|Clostridia J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 LANLAPFM_01994 1410650.JHWL01000003_gene2985 3.97e-47 183.0 28I6K@1|root,2Z89I@2|Bacteria,1UQ1M@1239|Firmicutes,24A0B@186801|Clostridia,4BWIK@830|Butyrivibrio 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_01995 585394.RHOM_04030 3.34e-193 538.0 COG0167@1|root,COG0167@2|Bacteria,1TPFV@1239|Firmicutes,248CQ@186801|Clostridia 186801|Clostridia F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily pyrD - 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh LANLAPFM_01996 622312.ROSEINA2194_02248 6.21e-164 461.0 COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia 186801|Clostridia C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( pyrK - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 LANLAPFM_01997 585394.RHOM_04020 1.65e-267 738.0 COG0044@1|root,COG0044@2|Bacteria,1TPQM@1239|Firmicutes,247V2@186801|Clostridia 186801|Clostridia F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 LANLAPFM_01998 585394.RHOM_04015 2.02e-248 687.0 COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia 186801|Clostridia S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 LANLAPFM_01999 622312.ROSEINA2194_02245 5.38e-144 421.0 COG0457@1|root,COG0457@2|Bacteria,1V4J9@1239|Firmicutes,24HT2@186801|Clostridia 186801|Clostridia M Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 LANLAPFM_02000 1415775.U729_2133 5.02e-73 223.0 COG3153@1|root,COG3153@2|Bacteria,1UK0D@1239|Firmicutes,25FG9@186801|Clostridia,36V06@31979|Clostridiaceae 186801|Clostridia S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_9 LANLAPFM_02001 585394.RHOM_05980 1.66e-62 197.0 COG1595@1|root,COG1595@2|Bacteria,1V734@1239|Firmicutes,24MQB@186801|Clostridia 186801|Clostridia K Belongs to the sigma-70 factor family. ECF subfamily sigV - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 LANLAPFM_02002 585394.RHOM_05985 1e-107 323.0 COG5513@1|root,COG5513@2|Bacteria,1UIU3@1239|Firmicutes,25ERV@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF3298) rsiV - - - - - - - - - - - DUF3298,DUF4163 LANLAPFM_02003 411902.CLOBOL_02174 4.31e-154 452.0 COG1696@1|root,COG1696@2|Bacteria,1TP52@1239|Firmicutes,248V4@186801|Clostridia,21Z7N@1506553|Lachnoclostridium 186801|Clostridia M MBOAT, membrane-bound O-acyltransferase family - - - ko:K19294 - - - - ko00000 - - - MBOAT LANLAPFM_02004 742733.HMPREF9469_01435 1.6e-55 188.0 COG2755@1|root,COG2755@2|Bacteria,1V2MD@1239|Firmicutes,24FWG@186801|Clostridia,2201W@1506553|Lachnoclostridium 186801|Clostridia E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - Lipase_GDSL_2 LANLAPFM_02005 585394.RHOM_04340 6.77e-261 719.0 28HI8@1|root,2Z7TS@2|Bacteria,1TQTK@1239|Firmicutes,249WK@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF4317 LANLAPFM_02006 585394.RHOM_04335 1.02e-83 250.0 COG1329@1|root,COG1329@2|Bacteria,1VAA0@1239|Firmicutes,24P60@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - ko:K07736 - - - - ko00000,ko03000 - - - CarD_CdnL_TRCF LANLAPFM_02007 622312.ROSEINA2194_00338 1.03e-134 389.0 2C6CR@1|root,2Z7X4@2|Bacteria,1UY2Y@1239|Firmicutes,24EJP@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K07089 - - - - ko00000 - - - ArsP_2 LANLAPFM_02008 622312.ROSEINA2194_00337 6.75e-76 228.0 COG0735@1|root,COG0735@2|Bacteria,1V970@1239|Firmicutes,24QK7@186801|Clostridia 186801|Clostridia P Belongs to the Fur family - - - ko:K03711 - - - - ko00000,ko03000 - - - FUR LANLAPFM_02009 585394.RHOM_05320 3.69e-175 497.0 COG0739@1|root,COG0739@2|Bacteria,1TQMQ@1239|Firmicutes,24B3J@186801|Clostridia 186801|Clostridia M COG0739 Membrane proteins related to metalloendopeptidases - - - ko:K21472 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 LANLAPFM_02010 585394.RHOM_05325 3.6e-200 577.0 COG2199@1|root,COG2984@1|root,COG2199@2|Bacteria,COG2984@2|Bacteria,1TS5J@1239|Firmicutes,25E4Y@186801|Clostridia 186801|Clostridia T Diguanylate cyclase (GGDEF) domain - - - - - - - - - - - - ABC_sub_bind,GGDEF,PAS_3,PAS_9 LANLAPFM_02011 585394.RHOM_05330 0.0 1159.0 COG1217@1|root,COG1217@2|Bacteria,1TQ5Y@1239|Firmicutes,248EB@186801|Clostridia 186801|Clostridia T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2 LANLAPFM_02012 622312.ROSEINA2194_00317 4.16e-137 389.0 COG0629@1|root,COG0629@2|Bacteria,1TRWZ@1239|Firmicutes,248UD@186801|Clostridia 186801|Clostridia L PFAM single-strand binding protein Primosomal replication protein n ssb1 - - - - - - - - - - - SSB LANLAPFM_02013 585394.RHOM_05340 8.91e-179 501.0 COG0329@1|root,COG0329@2|Bacteria,1TPCK@1239|Firmicutes,247T5@186801|Clostridia 186801|Clostridia E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS LANLAPFM_02014 585394.RHOM_05350 5.25e-149 423.0 COG0289@1|root,COG0289@2|Bacteria,1TR9D@1239|Firmicutes,248FY@186801|Clostridia 186801|Clostridia E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS17035 DapB_C,DapB_N LANLAPFM_02015 585394.RHOM_05355 0.0 1157.0 COG3855@1|root,COG3855@2|Bacteria,1TPFU@1239|Firmicutes,248ZC@186801|Clostridia 186801|Clostridia G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 fbp - 3.1.3.11 ko:K04041 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 - - - FBPase_2 LANLAPFM_02016 585394.RHOM_05365 1.98e-160 453.0 COG0648@1|root,COG0648@2|Bacteria,1TP1D@1239|Firmicutes,2499E@186801|Clostridia 186801|Clostridia L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo - 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 LANLAPFM_02017 585394.RHOM_05370 0.0 872.0 COG1982@1|root,COG1982@2|Bacteria,1TNZ9@1239|Firmicutes,247RA@186801|Clostridia 186801|Clostridia E Orn Lys Arg decarboxylase major speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - OKR_DC_1,OKR_DC_1_C LANLAPFM_02018 585394.RHOM_05375 1.38e-191 533.0 COG0421@1|root,COG0421@2|Bacteria,1TPG5@1239|Firmicutes,24827@186801|Clostridia 186801|Clostridia H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth LANLAPFM_02019 585394.RHOM_05380 3.63e-288 788.0 COG1748@1|root,COG1748@2|Bacteria,1TQTN@1239|Firmicutes,24AHW@186801|Clostridia 186801|Clostridia E Saccharopine dehydrogenase LYS1 - 1.5.1.7 ko:K00290 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715 RC00217,RC01532 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP LANLAPFM_02020 585394.RHOM_05385 1.57e-213 597.0 COG0019@1|root,COG0019@2|Bacteria,1TPQI@1239|Firmicutes,248NH@186801|Clostridia 186801|Clostridia E carboxynorspermidine decarboxylase nspC - 4.1.1.96 ko:K13747 ko00330,ko01100,map00330,map01100 - R09081,R09082 RC00299 ko00000,ko00001,ko01000 - - - Orn_DAP_Arg_deC LANLAPFM_02021 585394.RHOM_05390 1.37e-178 510.0 COG2957@1|root,COG2957@2|Bacteria,1TQS5@1239|Firmicutes,248CP@186801|Clostridia 186801|Clostridia E agmatine deiminase aguA - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph LANLAPFM_02022 585394.RHOM_05395 6.32e-178 499.0 COG0388@1|root,COG0388@2|Bacteria,1TRMU@1239|Firmicutes,25B19@186801|Clostridia 186801|Clostridia S N-carbamoylputrescine amidase aguB - 3.5.1.53,3.5.1.6 ko:K01431,ko:K12251 ko00240,ko00330,ko00410,ko00770,ko00983,ko01100,map00240,map00330,map00410,map00770,map00983,map01100 M00046 R00905,R01152,R04666,R08228 RC00096 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase LANLAPFM_02023 585394.RHOM_11155 2.89e-227 627.0 COG2502@1|root,COG2502@2|Bacteria,1TP28@1239|Firmicutes,248S4@186801|Clostridia 186801|Clostridia E aspartate--ammonia ligase asnA - 6.3.1.1 ko:K01914 ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230 - R00483 RC00010 ko00000,ko00001,ko01000 - - - AsnA LANLAPFM_02024 641107.CDLVIII_5672 2.81e-33 124.0 COG1898@1|root,COG1898@2|Bacteria,1TRVB@1239|Firmicutes,248VX@186801|Clostridia,36DWD@31979|Clostridiaceae 186801|Clostridia M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom LANLAPFM_02025 1280671.AUJH01000002_gene2226 1.05e-173 492.0 COG0310@1|root,COG0310@2|Bacteria,1TPEN@1239|Firmicutes,248S9@186801|Clostridia,4BW72@830|Butyrivibrio 186801|Clostridia P PDGLE domain cbiM2 - - ko:K02007 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiM,PDGLE LANLAPFM_02026 457396.CSBG_01568 1.9e-92 280.0 COG0619@1|root,COG0619@2|Bacteria,1U6XW@1239|Firmicutes,24EV0@186801|Clostridia,36FJU@31979|Clostridiaceae 186801|Clostridia P Cobalt ABC transporter, permease cbiQ - - ko:K02008 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiQ LANLAPFM_02027 1235792.C808_04034 1.06e-104 311.0 COG1122@1|root,COG1122@2|Bacteria,1TSSM@1239|Firmicutes,249KS@186801|Clostridia,27KCE@186928|unclassified Lachnospiraceae 186801|Clostridia P AAA domain, putative AbiEii toxin, Type IV TA system cbiO - - ko:K02006 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - ABC_tran LANLAPFM_02029 397287.C807_03129 0.0 1235.0 COG5426@1|root,COG5426@2|Bacteria,1TPH0@1239|Firmicutes,24892@186801|Clostridia,27J14@186928|unclassified Lachnospiraceae 186801|Clostridia S Lacto-N-biose phosphorylase C-terminal domain - - 2.4.1.211 ko:K15533 - - - - ko00000,ko01000 - - - LBP_C,LBP_M,Lact_bio_phlase LANLAPFM_02030 585394.RHOM_06405 6.83e-98 288.0 COG1309@1|root,COG1309@2|Bacteria,1V7SY@1239|Firmicutes,24JI6@186801|Clostridia 186801|Clostridia K transcriptional regulator TetR family - - - - - - - - - - - - TetR_N LANLAPFM_02031 1235800.C819_03666 0.0 1100.0 COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,249UZ@186801|Clostridia,27TNA@186928|unclassified Lachnospiraceae 186801|Clostridia G Glycosyl hydrolases family 2, TIM barrel domain lacZ - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N LANLAPFM_02032 585394.RHOM_06415 1.32e-288 795.0 2BZA3@1|root,2Z7YV@2|Bacteria,1TSER@1239|Firmicutes,24AF5@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02033 585394.RHOM_06420 4.54e-260 721.0 COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,247VA@186801|Clostridia 186801|Clostridia G Psort location CytoplasmicMembrane, score 10.00 lacS - - ko:K03292,ko:K11104,ko:K16209 - - - - ko00000,ko02000 2.A.2,2.A.2.1,2.A.2.2 - - MFS_2 LANLAPFM_02034 622312.ROSEINA2194_01205 0.0 1191.0 COG3345@1|root,COG3345@2|Bacteria,1TQF4@1239|Firmicutes,2489F@186801|Clostridia 186801|Clostridia G alpha-galactosidase - - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Glyco_hydro_36C,Glyco_hydro_36N,Melibiase LANLAPFM_02035 483218.BACPEC_02162 2.15e-06 50.8 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia 186801|Clostridia V Mate efflux family protein - - - - - - - - - - - - MatE LANLAPFM_02036 536233.CLO_3167 1.47e-23 102.0 COG1763@1|root,COG1763@2|Bacteria,1VAIZ@1239|Firmicutes,24N6J@186801|Clostridia,36UPV@31979|Clostridiaceae 186801|Clostridia H selenium-dependent hydroxylase accessory protein YqeC yqeC - - - - - - - - - - - - LANLAPFM_02037 585394.RHOM_06540 1.34e-266 739.0 COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia 186801|Clostridia EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind LANLAPFM_02038 585394.RHOM_06545 1.19e-114 330.0 COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,24FR0@186801|Clostridia 186801|Clostridia EH TIGRFAM glutamine amidotransferase of anthranilate synthase trpG - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase LANLAPFM_02039 585394.RHOM_06550 2.98e-125 363.0 COG0134@1|root,COG0134@2|Bacteria,1TR94@1239|Firmicutes,249ZY@186801|Clostridia 186801|Clostridia E Belongs to the TrpC family trpC - 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS LANLAPFM_02040 697329.Rumal_1862 1.74e-46 160.0 COG0135@1|root,COG0135@2|Bacteria,1V6Y0@1239|Firmicutes,24HBQ@186801|Clostridia,3WM7Q@541000|Ruminococcaceae 186801|Clostridia E N-(5'phosphoribosyl)anthranilate (PRA) isomerase trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI LANLAPFM_02041 585394.RHOM_06560 4.24e-256 706.0 COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,24881@186801|Clostridia 186801|Clostridia E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20,5.3.1.24 ko:K01696,ko:K01817 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722,R03509 RC00209,RC00210,RC00700,RC00701,RC00945,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP,PRAI LANLAPFM_02042 585394.RHOM_06565 9.6e-137 392.0 COG0159@1|root,COG0159@2|Bacteria,1TPXA@1239|Firmicutes,248M2@186801|Clostridia 186801|Clostridia E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA LANLAPFM_02043 585394.RHOM_06570 5.55e-179 505.0 COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia 186801|Clostridia E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 LANLAPFM_02044 622312.ROSEINA2194_01198 7.42e-208 579.0 COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,248TR@186801|Clostridia 186801|Clostridia E Beta-eliminating lyase ltaE - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase LANLAPFM_02045 585394.RHOM_06580 9.08e-219 606.0 COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,248F3@186801|Clostridia 186801|Clostridia EJ L-asparaginase ansA - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase LANLAPFM_02046 585394.RHOM_06585 7.78e-79 241.0 COG1268@1|root,COG1268@2|Bacteria,1VAY6@1239|Firmicutes,24HPU@186801|Clostridia 186801|Clostridia S BioY family bioY - - ko:K03523 ko02010,map02010 M00581,M00582 - - ko00000,ko00001,ko00002,ko02000 2.A.88.1,2.A.88.2 - - BioY LANLAPFM_02048 622312.ROSEINA2194_01760 1.03e-257 711.0 COG0038@1|root,COG0038@2|Bacteria,1TPX0@1239|Firmicutes,247R4@186801|Clostridia 186801|Clostridia P Chloride transporter, ClC family clcA - - ko:K03281 - - - - ko00000 2.A.49 - - Voltage_CLC LANLAPFM_02049 1280694.AUJQ01000008_gene158 1.01e-134 399.0 COG3507@1|root,COG3507@2|Bacteria,1TPHA@1239|Firmicutes,24AKT@186801|Clostridia,3NGF5@46205|Pseudobutyrivibrio 186801|Clostridia G C-terminal of Glycosyl hydrolases family 43 - - 3.2.1.99 ko:K06113 - - - - ko00000,ko01000 - GH43 - Dockerin_1,GH43_C,Glyco_hydro_43,Laminin_G_3 LANLAPFM_02050 622312.ROSEINA2194_00234 2.96e-135 394.0 COG0042@1|root,COG0042@2|Bacteria,1TRJM@1239|Firmicutes,247R5@186801|Clostridia 186801|Clostridia J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - - - - - - - - - - Dus LANLAPFM_02051 903814.ELI_1175 7.3e-52 205.0 COG3209@1|root,COG3209@2|Bacteria,1UK8Y@1239|Firmicutes,24M4J@186801|Clostridia,25XIP@186806|Eubacteriaceae 186801|Clostridia M Listeria-Bacteroides repeat domain (List_Bact_rpt) - - - - - - - - - - - - Big_4,Flg_new,LRR_5 LANLAPFM_02052 180332.JTGN01000011_gene619 1.52e-35 155.0 COG4870@1|root,COG5492@1|root,COG4870@2|Bacteria,COG5492@2|Bacteria,1V2GU@1239|Firmicutes,24GPX@186801|Clostridia 186801|Clostridia O Papain family cysteine protease - - - - - - - - - - - - Beta_helix,Big_2,Flg_new,Peptidase_C1 LANLAPFM_02053 1449050.JNLE01000003_gene678 8.52e-192 559.0 COG1132@1|root,COG1132@2|Bacteria,1TPZP@1239|Firmicutes,249WV@186801|Clostridia,36EX9@31979|Clostridiaceae 186801|Clostridia V ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_tran LANLAPFM_02054 1449050.JNLE01000003_gene677 2.16e-171 508.0 COG1132@1|root,COG1132@2|Bacteria,1TPZP@1239|Firmicutes,249WV@186801|Clostridia,36EX9@31979|Clostridiaceae 186801|Clostridia V ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_tran LANLAPFM_02055 1541959.KQ51_01201 3.95e-99 298.0 COG3290@1|root,COG3290@2|Bacteria 2|Bacteria T protein histidine kinase activity - - 2.7.13.3 ko:K11614 ko02020,map02020 M00490 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c_5,PAS_9,SPOB_a LANLAPFM_02056 1449050.JNLE01000003_gene675 2.84e-75 235.0 COG3279@1|root,COG3279@2|Bacteria,1TSDB@1239|Firmicutes,24MQ4@186801|Clostridia,36KUT@31979|Clostridiaceae 186801|Clostridia KT response regulator - - - - - - - - - - - - LytTR,Response_reg LANLAPFM_02057 622312.ROSEINA2194_04066 1.29e-69 237.0 COG0840@1|root,COG0840@2|Bacteria,1V0JG@1239|Firmicutes,24A5M@186801|Clostridia 186801|Clostridia NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal LANLAPFM_02058 1235798.C817_05228 4.8e-117 350.0 COG0662@1|root,COG2169@1|root,COG0662@2|Bacteria,COG2169@2|Bacteria,1V9CR@1239|Firmicutes,24K6B@186801|Clostridia,27WPH@189330|Dorea 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18 LANLAPFM_02059 1226325.HMPREF1548_05583 0.0 1424.0 COG3957@1|root,COG3957@2|Bacteria,1TR23@1239|Firmicutes,24B8I@186801|Clostridia,36G82@31979|Clostridiaceae 186801|Clostridia G D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase xfp - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N LANLAPFM_02060 1536774.H70357_11880 2.38e-27 109.0 COG3315@1|root,COG3315@2|Bacteria,1TSGJ@1239|Firmicutes,4HCZS@91061|Bacilli,26V7A@186822|Paenibacillaceae 91061|Bacilli Q Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity - - - - - - - - - - - - LCM LANLAPFM_02061 138119.DSY4206 1.94e-21 94.0 COG3315@1|root,COG3315@2|Bacteria,1TSGJ@1239|Firmicutes,24IYG@186801|Clostridia,262CN@186807|Peptococcaceae 186801|Clostridia H Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity - - - - - - - - - - - - LCM LANLAPFM_02062 702450.CUW_0318 3.91e-17 79.7 COG1309@1|root,COG1309@2|Bacteria,1V8TI@1239|Firmicutes,3VTTK@526524|Erysipelotrichia 526524|Erysipelotrichia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N LANLAPFM_02063 585394.RHOM_06150 0.0 898.0 COG0369@1|root,COG1151@2|Bacteria,1TP8X@1239|Firmicutes,247IN@186801|Clostridia 186801|Clostridia C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O hcp - 1.7.99.1 ko:K05601 ko00910,map00910 - R00143 RC02797 ko00000,ko00001,ko01000 - - - Prismane LANLAPFM_02064 1226325.HMPREF1548_02216 1.67e-119 347.0 COG1145@1|root,COG1145@2|Bacteria,1TPAZ@1239|Firmicutes,249NJ@186801|Clostridia,36F9G@31979|Clostridiaceae 186801|Clostridia C binding domain protein - - - - - - - - - - - - Fer4,Fer4_6 LANLAPFM_02065 1123075.AUDP01000001_gene2395 6.31e-97 288.0 COG0664@1|root,COG0664@2|Bacteria,1TSP9@1239|Firmicutes,24FRD@186801|Clostridia,3WIW5@541000|Ruminococcaceae 186801|Clostridia K Cyclic nucleotide-binding domain protein - - - - - - - - - - - - HTH_Crp_2,cNMP_binding LANLAPFM_02066 1121344.JHZO01000005_gene292 1.43e-69 229.0 COG2206@1|root,COG2206@2|Bacteria,1VV1Y@1239|Firmicutes,2502J@186801|Clostridia 186801|Clostridia T HD domain - - - - - - - - - - - - HD LANLAPFM_02067 585394.RHOM_03410 3.12e-61 206.0 COG3064@1|root,COG3064@2|Bacteria,1V52J@1239|Firmicutes,24HMZ@186801|Clostridia 186801|Clostridia M Membrane - - - - - - - - - - - - - LANLAPFM_02068 622312.ROSEINA2194_02476 1.41e-105 313.0 COG1011@1|root,COG1011@2|Bacteria,1UIG9@1239|Firmicutes,25EMR@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - ko:K07025 - - - - ko00000 - - - HAD_2 LANLAPFM_02069 585394.RHOM_03400 1.66e-101 302.0 COG1191@1|root,COG1191@2|Bacteria,1TP3Q@1239|Firmicutes,2487Z@186801|Clostridia 186801|Clostridia K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released sigF - - ko:K03091 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 LANLAPFM_02070 585394.RHOM_03395 4.44e-69 212.0 COG2172@1|root,COG2172@2|Bacteria,1V6V2@1239|Firmicutes,24JPT@186801|Clostridia 186801|Clostridia F Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition spoIIAB - 2.7.11.1 ko:K06379 - - - - ko00000,ko01000 - - - HATPase_c_2 LANLAPFM_02071 622312.ROSEINA2194_02480 2.01e-42 141.0 COG1366@1|root,COG1366@2|Bacteria,1VENG@1239|Firmicutes,24R0X@186801|Clostridia 186801|Clostridia T Belongs to the anti-sigma-factor antagonist family spoIIAA - - ko:K06378 - - - - ko00000 - - - STAS LANLAPFM_02072 585394.RHOM_03385 1.56e-228 640.0 COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,1UI34@1239|Firmicutes,25F0K@186801|Clostridia 186801|Clostridia S Tetratricopeptide repeat - - - - - - - - - - - - TPR_11,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8 LANLAPFM_02073 622312.ROSEINA2194_02482 1.32e-20 82.4 2EGDA@1|root,33A54@2|Bacteria,1VKC8@1239|Firmicutes,24UDV@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_02074 585394.RHOM_03375 3.25e-191 546.0 COG1315@1|root,COG1315@2|Bacteria,1TR7W@1239|Firmicutes,24B18@186801|Clostridia 186801|Clostridia L PALM domain HD hydrolase domain and - - - ko:K09749 - - - - ko00000 - - - FapA,Jag_N LANLAPFM_02075 585394.RHOM_03370 0.0 1730.0 COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia 186801|Clostridia J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 LANLAPFM_02076 585394.RHOM_03360 0.0 1455.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia 186801|Clostridia V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran LANLAPFM_02078 622312.ROSEINA2194_02492 4.23e-172 484.0 COG0395@1|root,COG0395@2|Bacteria,1TS0R@1239|Firmicutes,248UX@186801|Clostridia 186801|Clostridia P ABC-type sugar transport system, permease component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 LANLAPFM_02079 622312.ROSEINA2194_02493 6.61e-164 463.0 COG1175@1|root,COG1175@2|Bacteria,1TS63@1239|Firmicutes,2489M@186801|Clostridia 186801|Clostridia G ABC-type sugar transport systems permease components - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 LANLAPFM_02080 411474.COPEUT_00843 1.66e-290 796.0 COG1373@1|root,COG1373@2|Bacteria,1TP7X@1239|Firmicutes,247ZX@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - ko:K07133 - - - - ko00000 - - - AAA_14,DUF4143 LANLAPFM_02081 622312.ROSEINA2194_00134 1.42e-229 635.0 COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia 186801|Clostridia J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 LANLAPFM_02082 585394.RHOM_09580 2.4e-158 448.0 COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,24838@186801|Clostridia 186801|Clostridia J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 LANLAPFM_02083 622312.ROSEINA2194_00131 5.6e-93 277.0 COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,25C8E@186801|Clostridia 186801|Clostridia J Psort location CytoplasmicMembrane, score prmC - - - - - - - - - - - DUF1385,MTS LANLAPFM_02084 1469948.JPNB01000002_gene2888 4.08e-84 258.0 COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,1TQ2W@1239|Firmicutes,24A5W@186801|Clostridia,36VIU@31979|Clostridiaceae 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18,HTH_AraC LANLAPFM_02085 622312.ROSEINA2194_03857 8.27e-111 318.0 COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia 186801|Clostridia E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35,4.2.1.85 ko:K01704,ko:K20453 ko00290,ko00660,ko00760,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map01100,map01110,map01120,map01210,map01230 M00432,M00535 R03069,R03896,R03898,R03968,R04001,R10170 RC00843,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C LANLAPFM_02086 585394.RHOM_08030 1.1e-294 805.0 COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia 186801|Clostridia E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35,4.2.1.85 ko:K01703,ko:K20452 ko00290,ko00660,ko00760,ko00966,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map00966,map01100,map01110,map01120,map01210,map01230 M00432,M00535 R03069,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00843,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS04465 Aconitase LANLAPFM_02087 585394.RHOM_08035 2.92e-184 515.0 COG0583@1|root,COG0583@2|Bacteria,1TR84@1239|Firmicutes,24BU7@186801|Clostridia 186801|Clostridia K lysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate LANLAPFM_02088 1235802.C823_04319 1.58e-49 162.0 COG0681@1|root,COG0681@2|Bacteria,1VFKY@1239|Firmicutes,24RQG@186801|Clostridia,25XJH@186806|Eubacteriaceae 186801|Clostridia U Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Peptidase_S24 LANLAPFM_02089 411469.EUBHAL_02535 1.15e-86 275.0 2DBZW@1|root,2ZC46@2|Bacteria,1V2V4@1239|Firmicutes,24H1D@186801|Clostridia 186801|Clostridia S Coenzyme PQQ synthesis protein D (PqqD) - - - - - - - - - - - - PqqD LANLAPFM_02090 585394.RHOM_08700 0.0 932.0 COG1132@1|root,COG1132@2|Bacteria,1TRJF@1239|Firmicutes,249CN@186801|Clostridia 186801|Clostridia V ABC-type multidrug transport system ATPase and permease - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_02091 585394.RHOM_08710 1.13e-55 175.0 28V59@1|root,2ZH8H@2|Bacteria,1W3K5@1239|Firmicutes,255DA@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02092 585394.RHOM_08705 1.16e-52 169.0 2BZS0@1|root,343DQ@2|Bacteria,1VZ4U@1239|Firmicutes,25450@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02093 1235799.C818_02800 5.62e-97 298.0 COG0392@1|root,COG0392@2|Bacteria,1TXG8@1239|Firmicutes,24A1A@186801|Clostridia,27K01@186928|unclassified Lachnospiraceae 186801|Clostridia S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms mprF - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM LANLAPFM_02094 97139.C824_04122 2.93e-77 236.0 2B66C@1|root,31Z3H@2|Bacteria,1V6U0@1239|Firmicutes,24ICU@186801|Clostridia,36J7Y@31979|Clostridiaceae 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - LANLAPFM_02095 1235792.C808_02507 2.18e-169 482.0 COG1216@1|root,COG1216@2|Bacteria,1VV6P@1239|Firmicutes,25EH9@186801|Clostridia,27JXT@186928|unclassified Lachnospiraceae 186801|Clostridia S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 LANLAPFM_02096 585394.RHOM_08720 1.72e-166 484.0 2DBEW@1|root,2Z8UY@2|Bacteria,1UYFJ@1239|Firmicutes,2489J@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF4874) - - - - - - - - - - - - DUF4832,DUF4874 LANLAPFM_02097 585394.RHOM_08730 2.7e-140 413.0 COG2244@1|root,COG2244@2|Bacteria,1V0I3@1239|Firmicutes,24F2V@186801|Clostridia 186801|Clostridia S Uncharacterised nucleotidyltransferase - - - - - - - - - - - - NTP_transf_5 LANLAPFM_02098 585394.RHOM_08735 1.87e-250 701.0 COG2244@1|root,COG2244@2|Bacteria,1TR1W@1239|Firmicutes,24917@186801|Clostridia 186801|Clostridia C Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3 LANLAPFM_02099 411479.BACUNI_00969 1.06e-49 176.0 COG0463@1|root,COG0463@2|Bacteria,4NQ67@976|Bacteroidetes,2G06Z@200643|Bacteroidia,4AV2G@815|Bacteroidaceae 976|Bacteroidetes M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 LANLAPFM_02100 585394.RHOM_08745 3.79e-92 291.0 28NI3@1|root,2ZBJM@2|Bacteria,1V27V@1239|Firmicutes,24FTG@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF4874) - - - - - - - - - - - - DUF4832,DUF4874 LANLAPFM_02101 585394.RHOM_08750 4.65e-142 406.0 COG1216@1|root,COG1216@2|Bacteria,1UAQP@1239|Firmicutes,25B5D@186801|Clostridia 186801|Clostridia S group 2 family protein - - - - - - - - - - - - Glycos_transf_2 LANLAPFM_02102 585394.RHOM_08755 3.51e-166 479.0 COG0438@1|root,COG0438@2|Bacteria,1V09V@1239|Firmicutes,24C11@186801|Clostridia 186801|Clostridia M glycosyl transferase group 1 - - - - - - - - - - - - Glycos_transf_1 LANLAPFM_02103 1235802.C823_04311 1.87e-10 61.6 2EA00@1|root,3345F@2|Bacteria,1VJQ9@1239|Firmicutes,24R0V@186801|Clostridia,25Z91@186806|Eubacteriaceae 186801|Clostridia - - - - - - - - - - - - - - DUF2304 LANLAPFM_02104 585394.RHOM_08765 4.42e-250 697.0 COG4267@1|root,COG4267@2|Bacteria,1TRZE@1239|Firmicutes,24EQ7@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K21012 ko02025,map02025 - - - ko00000,ko00001 - - - PelG LANLAPFM_02105 585394.RHOM_08770 3.31e-244 682.0 COG0438@1|root,COG0438@2|Bacteria,1TQ8U@1239|Firmicutes,24BAM@186801|Clostridia 186801|Clostridia M Psort location Cytoplasmic, score - - - ko:K21011 ko02025,map02025 - - - ko00000,ko00001,ko01003 - GT4 - DUF3492,Glycos_transf_1 LANLAPFM_02106 585394.RHOM_08775 3.07e-184 541.0 28HJQ@1|root,2Z7UU@2|Bacteria,1UPMJ@1239|Firmicutes,24BW1@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - DUF2194 LANLAPFM_02107 1235792.C808_02976 1.91e-09 57.4 28N1Z@1|root,2ZB7X@2|Bacteria,1UZID@1239|Firmicutes,24F7M@186801|Clostridia,27QZP@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02108 585394.RHOM_13160 6.35e-262 722.0 COG0448@1|root,COG0448@2|Bacteria,1TNZW@1239|Firmicutes,24943@186801|Clostridia 186801|Clostridia H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase LANLAPFM_02109 585394.RHOM_13155 2.53e-246 679.0 COG0448@1|root,COG0448@2|Bacteria,1TPZ3@1239|Firmicutes,2482Q@186801|Clostridia 186801|Clostridia G glucose-1-phosphate adenylyltransferase GlgD subunit glgD - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase LANLAPFM_02110 622312.ROSEINA2194_01451 1.19e-50 160.0 COG2088@1|root,COG2088@2|Bacteria,1V9ZG@1239|Firmicutes,24MVQ@186801|Clostridia 186801|Clostridia D Could be involved in septation spoVG - - ko:K06412 - - - - ko00000 - - - SpoVG LANLAPFM_02111 585394.RHOM_03320 0.0 1523.0 COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia 186801|Clostridia G Glycosyltransferase 36 associated - - 2.4.1.20 ko:K00702 ko00500,ko01100,map00500,map01100 - R00952 RC00049 ko00000,ko00001,ko01000 - GT36 - Glyco_hydro_36,Glyco_transf_36 LANLAPFM_02112 515620.EUBELI_00158 2.53e-164 463.0 COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,1V2SW@1239|Firmicutes,24GTR@186801|Clostridia,25XBA@186806|Eubacteriaceae 186801|Clostridia K COG2207 AraC-type DNA-binding domain-containing proteins - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC LANLAPFM_02113 515620.EUBELI_00156 1.65e-253 704.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,25VVF@186806|Eubacteriaceae 186801|Clostridia V MATE efflux family protein - - - - - - - - - - - - MatE LANLAPFM_02114 585394.RHOM_03315 0.0 965.0 COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia 186801|Clostridia G Belongs to the pyruvate kinase family pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PEP-utilizers,PK,PK_C LANLAPFM_02115 622312.ROSEINA2194_04415 6.74e-200 556.0 COG0549@1|root,COG0549@2|Bacteria,1TP9H@1239|Firmicutes,2482W@186801|Clostridia 186801|Clostridia E carbamate kinase arcC - 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase LANLAPFM_02116 585394.RHOM_03305 8.81e-133 377.0 COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,24836@186801|Clostridia 186801|Clostridia D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 LANLAPFM_02117 585394.RHOM_03300 0.0 1167.0 COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia 186801|Clostridia O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C LANLAPFM_02118 585394.RHOM_03295 6.72e-269 740.0 COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,2481T@186801|Clostridia 186801|Clostridia O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX LANLAPFM_02119 585394.RHOM_03290 6.78e-127 362.0 COG0740@1|root,COG0740@2|Bacteria,1TQ91@1239|Firmicutes,247QY@186801|Clostridia 186801|Clostridia OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease LANLAPFM_02120 585394.RHOM_03285 3.08e-256 710.0 COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,248C3@186801|Clostridia 186801|Clostridia D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N LANLAPFM_02121 397291.C804_02341 3.58e-78 245.0 COG0127@1|root,COG0127@2|Bacteria,1V85S@1239|Firmicutes,24KX4@186801|Clostridia,27NVI@186928|unclassified Lachnospiraceae 186801|Clostridia F Ham1 family - - - - - - - - - - - - Ham1p_like LANLAPFM_02122 511680.BUTYVIB_00807 2.96e-76 231.0 COG1051@1|root,COG1051@2|Bacteria,1V3IM@1239|Firmicutes,24HEA@186801|Clostridia,4BZAJ@830|Butyrivibrio 186801|Clostridia F NUDIX domain mutX - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX LANLAPFM_02123 585394.RHOM_03230 0.0 1045.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_02124 585394.RHOM_03220 0.0 904.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_02125 1280698.AUJS01000061_gene1112 3.71e-100 296.0 COG1403@1|root,COG1403@2|Bacteria,1V5KT@1239|Firmicutes,24N2K@186801|Clostridia 186801|Clostridia V Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_02126 411462.DORLON_00146 1.27e-28 109.0 COG2364@1|root,COG2364@2|Bacteria,1V19X@1239|Firmicutes,24DJ8@186801|Clostridia,27VXU@189330|Dorea 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - LANLAPFM_02127 33035.JPJF01000073_gene4424 3.1e-19 85.9 COG2364@1|root,COG2364@2|Bacteria,1UXHA@1239|Firmicutes,24AJQ@186801|Clostridia,3Y0DC@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - LANLAPFM_02129 537007.BLAHAN_04922 1.86e-52 170.0 COG0454@1|root,COG0456@2|Bacteria,1VAFS@1239|Firmicutes,24MUI@186801|Clostridia,3Y0CK@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - ko:K03826 - - - - ko00000,ko01000 - - - Acetyltransf_10,Acetyltransf_7 LANLAPFM_02130 622312.ROSEINA2194_00096 2.34e-96 290.0 COG1266@1|root,COG1266@2|Bacteria,1V7EK@1239|Firmicutes,24KV5@186801|Clostridia 186801|Clostridia S CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi LANLAPFM_02131 622312.ROSEINA2194_00090 0.0 1265.0 COG0188@1|root,COG0188@2|Bacteria,1TPNX@1239|Firmicutes,24ADK@186801|Clostridia 186801|Clostridia L COG0188 Type IIA topoisomerase (DNA gyrase topo II, topoisomerase IV), A subunit gyrA_1 - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV LANLAPFM_02132 585394.RHOM_09675 0.0 1204.0 COG0187@1|root,COG0187@2|Bacteria,1TRSZ@1239|Firmicutes,247ZY@186801|Clostridia 186801|Clostridia L COG0187 Type IIA topoisomerase (DNA gyrase topo II, topoisomerase IV), B subunit parE - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim LANLAPFM_02133 585394.RHOM_09685 8.88e-220 611.0 COG3835@1|root,COG3835@2|Bacteria,1TQWD@1239|Firmicutes,24ZMW@186801|Clostridia 186801|Clostridia KT Psort location Cytoplasmic, score - - - ko:K02647 - - - - ko00000,ko03000 - - - HTH_30 LANLAPFM_02134 585394.RHOM_09690 1.56e-255 702.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia 186801|Clostridia P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system ugpC_1 - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE,TOBE_2 LANLAPFM_02135 1235793.C809_04227 6.49e-106 313.0 COG0300@1|root,COG0300@2|Bacteria,1TRP8@1239|Firmicutes,24DNY@186801|Clostridia,27N1X@186928|unclassified Lachnospiraceae 186801|Clostridia S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short LANLAPFM_02136 585394.RHOM_12890 9.42e-151 434.0 COG1533@1|root,COG1533@2|Bacteria,1TPA3@1239|Firmicutes,249NM@186801|Clostridia 186801|Clostridia L Spore photoproduct lyase - - 4.1.99.14 ko:K03716 - - - - ko00000,ko01000 - - - - LANLAPFM_02137 1235802.C823_04351 1.03e-59 200.0 COG0775@1|root,COG0775@2|Bacteria,1VCJY@1239|Firmicutes,24CRR@186801|Clostridia 186801|Clostridia F PFAM purine or other phosphorylase family 1 - - - - - - - - - - - - PNP_UDP_1 LANLAPFM_02138 1235802.C823_02304 5.72e-83 247.0 COG0756@1|root,COG0756@2|Bacteria,1V5PP@1239|Firmicutes,24I3J@186801|Clostridia,25W99@186806|Eubacteriaceae 186801|Clostridia F dUTPase dut - 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase LANLAPFM_02139 585394.RHOM_09700 2.98e-209 582.0 COG0240@1|root,COG0240@2|Bacteria,1TQ5P@1239|Firmicutes,248JT@186801|Clostridia 186801|Clostridia I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N LANLAPFM_02140 585394.RHOM_09705 4.06e-124 357.0 COG0344@1|root,COG0344@2|Bacteria,1VA3J@1239|Firmicutes,24JA2@186801|Clostridia 186801|Clostridia I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf LANLAPFM_02141 585394.RHOM_09710 7.84e-301 822.0 COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia 186801|Clostridia S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 LANLAPFM_02142 585394.RHOM_09715 1.54e-169 505.0 COG1277@1|root,COG1277@2|Bacteria,1TRJ8@1239|Firmicutes,24EMN@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - - LANLAPFM_02143 585394.RHOM_09720 1.56e-185 519.0 COG1131@1|root,COG1131@2|Bacteria,1TPQW@1239|Firmicutes,248F7@186801|Clostridia 186801|Clostridia V Abc transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran LANLAPFM_02144 585394.RHOM_09725 5.37e-57 179.0 COG1725@1|root,COG1725@2|Bacteria,1VFD0@1239|Firmicutes,24MTU@186801|Clostridia 186801|Clostridia K Transcriptional regulator, GntR family - - - ko:K07979 - - - - ko00000,ko03000 - - - GntR LANLAPFM_02145 622312.ROSEINA2194_00078 1.1e-191 537.0 COG1363@1|root,COG1363@2|Bacteria,1TQ86@1239|Firmicutes,25CDF@186801|Clostridia 186801|Clostridia G M42 glutamyl aminopeptidase - - - - - - - - - - - - Peptidase_M42 LANLAPFM_02146 1458462.JNLK01000001_gene1937 3.11e-156 452.0 COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248IH@186801|Clostridia,27K39@186928|unclassified Lachnospiraceae 186801|Clostridia S ABC transporter substrate-binding protein PnrA-like - - - ko:K07335 - - - - ko00000 - - - Bmp LANLAPFM_02147 1458462.JNLK01000001_gene1936 0.0 1082.0 COG2206@1|root,COG3275@1|root,COG3292@1|root,COG2206@2|Bacteria,COG3275@2|Bacteria,COG3292@2|Bacteria,1UZN2@1239|Firmicutes,25EWN@186801|Clostridia 186801|Clostridia T metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - DUF3369,GAF_2,HAMP,HD,HD_5,PAS_9,Reg_prop,Response_reg,Y_Y_Y,dCache_1 LANLAPFM_02148 411461.DORFOR_02222 3.57e-96 287.0 COG3404@1|root,COG3404@2|Bacteria,1V14R@1239|Firmicutes,24D90@186801|Clostridia,27VNB@189330|Dorea 186801|Clostridia E Formiminotransferase-cyclodeaminase fchA - - - - - - - - - - - FTCD_C LANLAPFM_02149 411462.DORLON_02488 5.51e-156 443.0 COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,248DB@186801|Clostridia,27VGK@189330|Dorea 186801|Clostridia F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C LANLAPFM_02150 622312.ROSEINA2194_04370 1.97e-158 462.0 COG1373@1|root,COG1373@2|Bacteria,1TQ8Z@1239|Firmicutes,2499K@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - AAA_14,DUF4143 LANLAPFM_02151 585394.RHOM_11425 0.0 1398.0 COG1482@1|root,COG2723@1|root,COG1482@2|Bacteria,COG2723@2|Bacteria,1TP19@1239|Firmicutes,2485V@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 1 family - - 3.2.1.21 ko:K05350 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - - - Glyco_hydro_1,PMI_typeI LANLAPFM_02152 585394.RHOM_11430 4.4e-174 496.0 COG2755@1|root,COG2755@2|Bacteria,1TQG2@1239|Firmicutes,24A1G@186801|Clostridia 186801|Clostridia E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 LANLAPFM_02153 585394.RHOM_11435 1.01e-181 513.0 COG2755@1|root,COG2755@2|Bacteria,1TS75@1239|Firmicutes,24DPZ@186801|Clostridia 186801|Clostridia E cellulose binding - - - - - - - - - - - - Lipase_GDSL_2 LANLAPFM_02154 585394.RHOM_11440 1.27e-248 682.0 COG2152@1|root,COG2152@2|Bacteria,1TQE7@1239|Firmicutes,249D0@186801|Clostridia 186801|Clostridia G PFAM Glycosidase - - 2.4.1.319,2.4.1.320 ko:K18785 - - R10811,R10829 RC00049 ko00000,ko01000 - - - Glyco_hydro_130 LANLAPFM_02155 585394.RHOM_11445 4e-278 761.0 COG2152@1|root,COG2152@2|Bacteria,1TNYI@1239|Firmicutes,24A1K@186801|Clostridia 186801|Clostridia G Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose - - 2.4.1.281 ko:K16212 - - R09943 RC00049 ko00000,ko01000 - - - Glyco_hydro_130 LANLAPFM_02156 585394.RHOM_11450 5.55e-246 681.0 COG2942@1|root,COG2942@2|Bacteria,1TQMG@1239|Firmicutes,24C1F@186801|Clostridia 186801|Clostridia G Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man) - - 5.1.3.11 ko:K16213 - - R01445,R10810 RC00289 ko00000,ko01000 - - - GlcNAc_2-epim LANLAPFM_02157 1410616.JHXE01000013_gene255 9.83e-163 461.0 COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249ZC@186801|Clostridia,3NGCJ@46205|Pseudobutyrivibrio 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 LANLAPFM_02158 1469948.JPNB01000002_gene3876 3.3e-178 503.0 COG1175@1|root,COG1175@2|Bacteria,1TQHI@1239|Firmicutes,247ZB@186801|Clostridia,36HT0@31979|Clostridiaceae 186801|Clostridia G PFAM Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 LANLAPFM_02159 1280673.AUJJ01000009_gene3083 1.52e-236 664.0 COG1653@1|root,COG1653@2|Bacteria,1TS0C@1239|Firmicutes,249WW@186801|Clostridia,4BZ2U@830|Butyrivibrio 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1 LANLAPFM_02160 1235793.C809_00618 1.35e-68 212.0 COG0315@1|root,COG0315@2|Bacteria,1V3J4@1239|Firmicutes,24H9F@186801|Clostridia,27MYG@186928|unclassified Lachnospiraceae 186801|Clostridia H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC LANLAPFM_02161 1298920.KI911353_gene811 2.79e-76 231.0 COG0521@1|root,COG0521@2|Bacteria,1V3XM@1239|Firmicutes,24HG2@186801|Clostridia,21Z3U@1506553|Lachnoclostridium 186801|Clostridia H Molybdenum cofactor synthesis domain protein mog - - - - - - - - - - - MOSC,MoCF_biosynth LANLAPFM_02162 1256908.HMPREF0373_01402 1.05e-98 293.0 COG0425@1|root,COG0425@2|Bacteria,1V6BY@1239|Firmicutes,24JW8@186801|Clostridia,25X3M@186806|Eubacteriaceae 186801|Clostridia O DsrE/DsrF-like family yedF - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DrsE,TusA LANLAPFM_02163 1298920.KI911353_gene785 6.13e-174 496.0 COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,249CS@186801|Clostridia,21Z7G@1506553|Lachnoclostridium 186801|Clostridia E Cysteine desulfurase family protein - - - - - - - - - - - - Aminotran_5 LANLAPFM_02164 1235792.C808_01660 3.54e-193 542.0 COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,247NS@186801|Clostridia,27JZ4@186928|unclassified Lachnospiraceae 186801|Clostridia H Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C LANLAPFM_02165 1256908.HMPREF0373_00762 3.84e-29 105.0 29XBV@1|root,30J1M@2|Bacteria,1U4VY@1239|Firmicutes,25NV8@186801|Clostridia,25Z8B@186806|Eubacteriaceae 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF3343 LANLAPFM_02166 657322.FPR_30730 1.02e-124 363.0 COG3608@1|root,COG3608@2|Bacteria,1TRKT@1239|Firmicutes,2492W@186801|Clostridia,3WI66@541000|Ruminococcaceae 186801|Clostridia S Selenium-dependent molybdenum hydroxylase system protein, YqeB family - - - ko:K07402 - - - - ko00000 - - - NTP_transf_3 LANLAPFM_02167 411469.EUBHAL_01351 1.92e-195 547.0 COG0303@1|root,COG0303@2|Bacteria,1TP7F@1239|Firmicutes,247TZ@186801|Clostridia,25VS2@186806|Eubacteriaceae 186801|Clostridia H Probable molybdopterin binding domain moeA2 - - - - - - - - - - - MoCF_biosynth LANLAPFM_02168 658088.HMPREF0987_01753 7.18e-109 328.0 COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,247PP@186801|Clostridia,27IWC@186928|unclassified Lachnospiraceae 186801|Clostridia H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM LANLAPFM_02169 1256908.HMPREF0373_01761 7.91e-82 244.0 COG2258@1|root,COG2258@2|Bacteria,1V6DS@1239|Firmicutes,24HBA@186801|Clostridia,25X6H@186806|Eubacteriaceae 186801|Clostridia S MOSC domain - - - - - - - - - - - - MOSC,MoCF_biosynth LANLAPFM_02170 626939.HMPREF9443_01887 1.85e-88 274.0 COG1975@1|root,COG1975@2|Bacteria,1URM5@1239|Firmicutes,4H521@909932|Negativicutes 909932|Negativicutes O XdhC and CoxI family - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI LANLAPFM_02171 1042156.CXIVA_05850 1.46e-126 371.0 COG0725@1|root,COG0725@2|Bacteria,1U9U3@1239|Firmicutes,249VA@186801|Clostridia,36EBM@31979|Clostridiaceae 186801|Clostridia P ABC transporter, periplasmic molybdate-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - iHN637.CLJU_RS12820 SBP_bac_11 LANLAPFM_02172 411468.CLOSCI_02058 5.26e-131 375.0 COG4149@1|root,COG4149@2|Bacteria,1TRNA@1239|Firmicutes,24BR9@186801|Clostridia,21XZN@1506553|Lachnoclostridium 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 LANLAPFM_02173 1042156.CXIVA_05830 7.39e-124 368.0 COG1118@1|root,COG1118@2|Bacteria,1UI1E@1239|Firmicutes,25EAE@186801|Clostridia,36EU6@31979|Clostridiaceae 186801|Clostridia P the current gene model (or a revised gene model) may contain a frame shift modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran LANLAPFM_02174 931626.Awo_c29210 1.33e-67 220.0 COG0583@1|root,COG0583@2|Bacteria,1TP6T@1239|Firmicutes,24970@186801|Clostridia,25WDP@186806|Eubacteriaceae 186801|Clostridia K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate LANLAPFM_02175 585394.RHOM_13830 1.45e-133 381.0 COG1760@1|root,COG1760@2|Bacteria,1U8TZ@1239|Firmicutes,24AEE@186801|Clostridia 186801|Clostridia E L-serine dehydratase, iron-sulfur-dependent, beta subunit sdaAB - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - ACT,SDH_beta LANLAPFM_02176 585394.RHOM_13825 4.8e-165 466.0 COG1760@1|root,COG1760@2|Bacteria,1TP79@1239|Firmicutes,2480J@186801|Clostridia 186801|Clostridia E L-serine dehydratase, iron-sulfur-dependent, alpha subunit sdaAA - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha LANLAPFM_02177 622312.ROSEINA2194_02263 1.93e-67 206.0 COG1725@1|root,COG1725@2|Bacteria,1VAC6@1239|Firmicutes,24MVE@186801|Clostridia 186801|Clostridia K PFAM Bacterial regulatory proteins, gntR family - - - - - - - - - - - - GntR LANLAPFM_02178 622312.ROSEINA2194_02264 8.25e-174 488.0 COG1131@1|root,COG1131@2|Bacteria,1TS5Y@1239|Firmicutes,24AH1@186801|Clostridia 186801|Clostridia V PFAM ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran LANLAPFM_02180 622312.ROSEINA2194_02266 1.3e-59 194.0 2DRS1@1|root,33CTC@2|Bacteria,1VPFR@1239|Firmicutes,24X55@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02181 585394.RHOM_13820 2.8e-316 862.0 COG0427@1|root,COG0427@2|Bacteria,1TPHC@1239|Firmicutes,247V0@186801|Clostridia 186801|Clostridia C PFAM Acetyl-CoA hydrolase transferase cat - - - - - - - - - - - AcetylCoA_hyd_C,AcetylCoA_hydro LANLAPFM_02182 585394.RHOM_12010 1.1e-235 649.0 COG1089@1|root,COG1089@2|Bacteria,1TQ9T@1239|Firmicutes,24863@186801|Clostridia 186801|Clostridia M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd LANLAPFM_02183 585394.RHOM_12005 4.97e-221 610.0 COG0451@1|root,COG0451@2|Bacteria,1TQV2@1239|Firmicutes,249R2@186801|Clostridia 186801|Clostridia GM Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction fcl - 1.1.1.271 ko:K02377 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R05692 RC01014 ko00000,ko00001,ko01000 - - - Epimerase LANLAPFM_02184 585394.RHOM_12000 4.95e-258 714.0 COG0836@1|root,COG1917@1|root,COG0836@2|Bacteria,COG1917@2|Bacteria,1TPC9@1239|Firmicutes,24908@186801|Clostridia 186801|Clostridia M PFAM Nucleotidyl transferase - - 2.7.7.13 ko:K00971 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase LANLAPFM_02185 585394.RHOM_05175 3.13e-161 452.0 COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia 186801|Clostridia G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - iHN637.CLJU_RS19265 TIM LANLAPFM_02187 585394.RHOM_05185 0.0 954.0 COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia 186801|Clostridia G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N LANLAPFM_02188 585394.RHOM_05190 2.44e-190 531.0 COG0152@1|root,COG0152@2|Bacteria 2|Bacteria F phosphoribosylaminoimidazolesuccinocarboxamide synthase activity purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 ko:K01923,ko:K01945,ko:K03566 ko00230,ko01100,ko01110,ko01130,ko02026,map00230,map01100,map01110,map01130,map02026 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000,ko03000 - - - SAICAR_synt LANLAPFM_02189 585394.RHOM_05195 0.0 893.0 COG0034@1|root,COG0034@2|Bacteria,1TPH3@1239|Firmicutes,247RF@186801|Clostridia 186801|Clostridia F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,GATase_7,Pribosyltran LANLAPFM_02190 622312.ROSEINA2194_03091 0.0 899.0 COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,2485N@186801|Clostridia 186801|Clostridia F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 LANLAPFM_02191 622312.ROSEINA2194_00711 1.25e-262 721.0 COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia 186801|Clostridia C alcohol dehydrogenase fucO - 1.1.1.77 ko:K00048 ko00630,ko00640,ko01120,map00630,map00640,map01120 - R01781,R02257 RC00087,RC00099 ko00000,ko00001,ko01000 - - - Fe-ADH LANLAPFM_02192 622312.ROSEINA2194_04423 8.18e-101 295.0 COG1309@1|root,COG1309@2|Bacteria,1U1ZX@1239|Firmicutes,24ERU@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - TetR_N LANLAPFM_02193 585394.RHOM_06020 0.0 917.0 COG1070@1|root,COG1070@2|Bacteria,1TP91@1239|Firmicutes,24A4Z@186801|Clostridia 186801|Clostridia G Carbohydrate kinase, FGGY family protein araB - - - - - - - - - - - FGGY_C,FGGY_N LANLAPFM_02194 585394.RHOM_06025 0.0 966.0 COG2160@1|root,COG2160@2|Bacteria,1TPXC@1239|Firmicutes,24A08@186801|Clostridia 186801|Clostridia G Catalyzes the conversion of L-arabinose to L-ribulose araA - 5.3.1.4 ko:K01804 ko00040,ko01100,map00040,map01100 - R01761 RC00516 ko00000,ko00001,ko01000 - - - Arabinose_Iso_C,Arabinose_Isome LANLAPFM_02195 585394.RHOM_06035 8.34e-147 414.0 COG0176@1|root,COG0176@2|Bacteria,1TP4Q@1239|Firmicutes,248KZ@186801|Clostridia 186801|Clostridia H Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA LANLAPFM_02196 1410612.JNKO01000001_gene2727 7.57e-167 470.0 COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,2PTU7@265975|Oribacterium 186801|Clostridia G Dehydrogenase E1 component tktA - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N LANLAPFM_02197 585394.RHOM_06045 1.82e-189 530.0 COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia 186801|Clostridia G Transketolase tktB - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C LANLAPFM_02198 585394.RHOM_06050 1.63e-169 473.0 COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia 186801|Clostridia G L-ribulose-5-phosphate 4-epimerase ulaF - 5.1.3.4 ko:K03077 ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120 M00550 R05850 RC01479 ko00000,ko00001,ko00002,ko01000 - - - Aldolase_II LANLAPFM_02199 585394.RHOM_06055 1.45e-175 498.0 COG2017@1|root,COG2017@2|Bacteria,1TQGJ@1239|Firmicutes,249DZ@186801|Clostridia 186801|Clostridia G Converts alpha-aldose to the beta-anomer mro - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim LANLAPFM_02200 622312.ROSEINA2194_04149 2.02e-227 648.0 COG4637@1|root,COG4637@2|Bacteria,1TQ9X@1239|Firmicutes,247NI@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - AAA-ATPase_like,PDDEXK_9 LANLAPFM_02201 478749.BRYFOR_05407 1.96e-89 282.0 COG0582@1|root,COG0582@2|Bacteria,1V16B@1239|Firmicutes,24CY2@186801|Clostridia 186801|Clostridia L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_3,Phage_integrase LANLAPFM_02202 140626.JHWB01000022_gene2115 1.24e-98 292.0 COG1011@1|root,COG1011@2|Bacteria,1V6I4@1239|Firmicutes,24JK7@186801|Clostridia 186801|Clostridia S HAD hydrolase, family IA, variant 3 - - - ko:K07025 - - - - ko00000 - - - HAD_2,Hydrolase LANLAPFM_02203 585394.RHOM_14265 3.18e-217 630.0 COG0577@1|root,COG0577@2|Bacteria,1TR2D@1239|Firmicutes,2481J@186801|Clostridia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX LANLAPFM_02204 1256908.HMPREF0373_02016 1.54e-144 412.0 COG1136@1|root,COG1136@2|Bacteria,1TNZG@1239|Firmicutes,247JX@186801|Clostridia,25V99@186806|Eubacteriaceae 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran LANLAPFM_02205 585394.RHOM_14275 3.92e-102 311.0 COG0642@1|root,COG0642@2|Bacteria,1TQSG@1239|Firmicutes,25EB7@186801|Clostridia 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c LANLAPFM_02206 1235793.C809_02063 5.49e-123 354.0 COG0745@1|root,COG0745@2|Bacteria,1TR32@1239|Firmicutes,249TG@186801|Clostridia,27IZY@186928|unclassified Lachnospiraceae 186801|Clostridia T Transcriptional regulatory protein, C terminal graR - - ko:K19082 ko02020,map02020 M00734,M00737 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C LANLAPFM_02207 585394.RHOM_14285 6.01e-226 625.0 COG0722@1|root,COG0722@2|Bacteria,1TQI4@1239|Firmicutes,24842@186801|Clostridia 186801|Clostridia E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) - - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 LANLAPFM_02208 585394.RHOM_15710 8.66e-143 424.0 COG3103@1|root,COG3773@1|root,COG3103@2|Bacteria,COG3773@2|Bacteria,1TRFW@1239|Firmicutes,24DDK@186801|Clostridia 186801|Clostridia MT Cell Wall Hydrolase - - - - - - - - - - - - Hydrolase_2,SH3_3 LANLAPFM_02210 585394.RHOM_15725 1.15e-211 590.0 COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia 186801|Clostridia M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 LANLAPFM_02211 622312.ROSEINA2194_00772 3.52e-85 252.0 COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia 186801|Clostridia FG PFAM Histidine triad (HIT) protein hit - - ko:K02503 - - - - ko00000,ko04147 - - - HIT LANLAPFM_02212 585394.RHOM_15740 2.5e-200 559.0 COG0655@1|root,COG3255@1|root,COG0655@2|Bacteria,COG3255@2|Bacteria,1TT0Y@1239|Firmicutes,247MH@186801|Clostridia 186801|Clostridia I SCP-2 sterol transfer family - - - - - - - - - - - - SCP2 LANLAPFM_02213 622312.ROSEINA2194_00769 1.22e-155 447.0 COG0705@1|root,COG0705@2|Bacteria,1TQXT@1239|Firmicutes,247PT@186801|Clostridia 186801|Clostridia S PFAM Rhomboid family gluP - 3.4.21.105 ko:K19225 - - - - ko00000,ko01000,ko01002 - - - Rhomboid LANLAPFM_02214 585394.RHOM_15750 1.79e-72 238.0 COG1716@1|root,COG1716@2|Bacteria,1V550@1239|Firmicutes,24BVK@186801|Clostridia 186801|Clostridia T (FHA) domain - - - - - - - - - - - - FHA LANLAPFM_02217 622312.ROSEINA2194_00764 4.55e-67 216.0 COG4961@1|root,COG4961@2|Bacteria,1V9E1@1239|Firmicutes,24ET0@186801|Clostridia 186801|Clostridia U Psort location Cytoplasmic, score - - - - - - - - - - - - TadE LANLAPFM_02218 585394.RHOM_15770 3.63e-105 330.0 2BXNJ@1|root,2ZC8M@2|Bacteria,1UYM5@1239|Firmicutes,24ASZ@186801|Clostridia 186801|Clostridia S Psort location - - - - - - - - - - - - - LANLAPFM_02219 397287.C807_03605 8.06e-11 58.2 2EHSI@1|root,33BI9@2|Bacteria,1VK7K@1239|Firmicutes,24UF9@186801|Clostridia,27QCR@186928|unclassified Lachnospiraceae 186801|Clostridia S Putative Flagellin, Flp1-like, domain - - - - - - - - - - - - Flp1_like LANLAPFM_02220 622312.ROSEINA2194_00761 9.66e-94 295.0 COG2064@1|root,COG2064@2|Bacteria,1V2C3@1239|Firmicutes,24AN4@186801|Clostridia 186801|Clostridia NU Psort location CytoplasmicMembrane, score - - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF LANLAPFM_02221 585394.RHOM_15785 1.64e-78 243.0 COG4965@1|root,COG4965@2|Bacteria,1V6PB@1239|Firmicutes,24JBR@186801|Clostridia 186801|Clostridia U Psort location CytoplasmicMembrane, score tadB - - ko:K12510 - - - - ko00000,ko02044 - - - T2SSF LANLAPFM_02222 585394.RHOM_15790 1.29e-195 554.0 COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,249VS@186801|Clostridia 186801|Clostridia U Type II IV secretion system protein ptlH - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE LANLAPFM_02223 585394.RHOM_15795 9.43e-93 287.0 COG1192@1|root,COG1192@2|Bacteria,1V11K@1239|Firmicutes,24FDX@186801|Clostridia 186801|Clostridia D Psort location Cytoplasmic, score - - - - - - - - - - - - AAA_31 LANLAPFM_02224 585394.RHOM_15800 1.64e-52 170.0 2EHCT@1|root,33B4M@2|Bacteria,1UPNG@1239|Firmicutes 1239|Firmicutes S Type IV leader peptidase family - - 3.4.23.43 ko:K02278 - - - - ko00000,ko01000,ko02035,ko02044 - - - Peptidase_A24 LANLAPFM_02226 1235790.C805_03392 5.65e-22 88.2 2EIA7@1|root,33C1J@2|Bacteria,1VMCK@1239|Firmicutes,24W47@186801|Clostridia,25XQS@186806|Eubacteriaceae 186801|Clostridia S Protein of unknown function (DUF2508) - - - - - - - - - - - - DUF2508 LANLAPFM_02227 585394.RHOM_15815 2.02e-68 211.0 COG1516@1|root,COG1516@2|Bacteria,1VD1Q@1239|Firmicutes,24PMH@186801|Clostridia 186801|Clostridia NOU Flagellar protein FliS - - - ko:K02422 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliS LANLAPFM_02228 585394.RHOM_15820 2.39e-201 575.0 COG1344@1|root,COG1344@2|Bacteria,1TP1K@1239|Firmicutes,247JQ@186801|Clostridia 186801|Clostridia N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella hag - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N LANLAPFM_02229 585394.RHOM_15825 7.4e-41 134.0 COG2846@1|root,COG2846@2|Bacteria,1VET8@1239|Firmicutes,24QPY@186801|Clostridia 186801|Clostridia D cluster protein-associated redox disulfide domain - - - - - - - - - - - - DUF1858 LANLAPFM_02230 585394.RHOM_15830 6.8e-127 368.0 COG4862@1|root,COG4862@2|Bacteria,1UZ7D@1239|Firmicutes,24BWV@186801|Clostridia 186801|Clostridia NOT Negative regulator of genetic competence mecB - - ko:K16511 - - - - ko00000 - - - MecA LANLAPFM_02231 622312.ROSEINA2194_00751 4.03e-134 401.0 COG0515@1|root,COG0515@2|Bacteria,1V3N4@1239|Firmicutes,25B6W@186801|Clostridia 186801|Clostridia KLT serine threonine protein kinase - - 2.7.11.1 ko:K08884 - - - - ko00000,ko01000,ko01001 - - - Pkinase LANLAPFM_02233 585394.RHOM_15850 4.45e-297 826.0 COG3858@1|root,COG3858@2|Bacteria,1TQK2@1239|Firmicutes,247YF@186801|Clostridia 186801|Clostridia M family 18 ydhD - - - - - - - - - - - CW_binding_2,Cu_amine_oxidN1,Glyco_hydro_18,SH3_3 LANLAPFM_02234 622312.ROSEINA2194_00744 1.6e-100 299.0 COG0860@1|root,COG0860@2|Bacteria,1TQ74@1239|Firmicutes,24FT2@186801|Clostridia 186801|Clostridia M N-Acetylmuramoyl-L-alanine amidase cwlD - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 LANLAPFM_02235 585394.RHOM_15860 0.0 1044.0 28ISF@1|root,2Z8RM@2|Bacteria,1TSK2@1239|Firmicutes,249Q2@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02236 585394.RHOM_15865 0.0 1206.0 COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia 186801|Clostridia G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 LANLAPFM_02237 585394.RHOM_15870 0.0 1024.0 COG0457@1|root,COG0464@1|root,COG0457@2|Bacteria,COG0464@2|Bacteria,1TY3C@1239|Firmicutes,248IE@186801|Clostridia 186801|Clostridia O Psort location Cytoplasmic, score SpoVK - - - - - - - - - - - TPR_8 LANLAPFM_02238 585394.RHOM_15875 1.08e-201 572.0 COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,248FS@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - AI-2E_transport LANLAPFM_02239 585394.RHOM_15890 0.0 1384.0 COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia 186801|Clostridia C aconitate hydratase ybhJ - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C LANLAPFM_02240 585394.RHOM_15900 0.0 974.0 COG5002@1|root,COG5002@2|Bacteria,1UM03@1239|Firmicutes,24F2S@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA LANLAPFM_02241 622312.ROSEINA2194_02189 7.98e-156 438.0 COG0745@1|root,COG0745@2|Bacteria,1TP9M@1239|Firmicutes,247TK@186801|Clostridia 186801|Clostridia KT response regulator receiver phoP_1 - - - - - - - - - - - Response_reg,Trans_reg_C LANLAPFM_02242 585394.RHOM_15910 8.34e-168 479.0 COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,248RH@186801|Clostridia 186801|Clostridia K Cell envelope-like function transcriptional attenuator common domain protein - - - - - - - - - - - - LytR_cpsA_psr LANLAPFM_02244 585394.RHOM_15935 3.98e-73 231.0 2C331@1|root,30RPK@2|Bacteria,1V3YF@1239|Firmicutes,24IF9@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02245 622312.ROSEINA2194_00858 0.0 887.0 COG0737@1|root,COG0737@2|Bacteria,1TPV2@1239|Firmicutes,2491Y@186801|Clostridia 186801|Clostridia F Belongs to the 5'-nucleotidase family - - 3.1.3.5,3.6.1.45 ko:K11751 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos LANLAPFM_02246 1227352.C173_26907 4.63e-54 199.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4HGPZ@91061|Bacilli,26V9X@186822|Paenibacillaceae 91061|Bacilli NT chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,dCache_1 LANLAPFM_02247 585394.RHOM_14940 0.0 1148.0 COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia 186801|Clostridia J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD LANLAPFM_02248 585394.RHOM_15950 4.1e-268 744.0 COG0737@1|root,COG0737@2|Bacteria,1TPV2@1239|Firmicutes,2491Y@186801|Clostridia 186801|Clostridia F Belongs to the 5'-nucleotidase family - - 3.1.3.6,3.1.4.16 ko:K01119 ko00230,ko00240,map00230,map00240 - R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135 RC00078,RC00296 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos LANLAPFM_02249 585394.RHOM_15955 1.68e-165 466.0 COG3639@1|root,COG3639@2|Bacteria,1TQ73@1239|Firmicutes,24AGQ@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component phnE_2 - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 LANLAPFM_02250 585394.RHOM_15960 3.6e-162 457.0 COG3639@1|root,COG3639@2|Bacteria,1TR1S@1239|Firmicutes,24A7G@186801|Clostridia 186801|Clostridia P phosphonate ABC transporter, permease protein PhnE phnE_1 - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 LANLAPFM_02251 585394.RHOM_15965 2.4e-157 444.0 COG3638@1|root,COG3638@2|Bacteria,1TQG6@1239|Firmicutes,249GS@186801|Clostridia 186801|Clostridia P Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system phnC - 3.6.3.28 ko:K02041 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.9 - - ABC_tran LANLAPFM_02252 585394.RHOM_15970 1.07e-200 563.0 COG3221@1|root,COG3221@2|Bacteria,1TR0H@1239|Firmicutes,24A3Q@186801|Clostridia 186801|Clostridia P ABC-type phosphate phosphonate transport system periplasmic component phnD - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd LANLAPFM_02253 585394.RHOM_15975 4.56e-165 469.0 COG1609@1|root,COG1609@2|Bacteria,1TPZJ@1239|Firmicutes,248K0@186801|Clostridia 186801|Clostridia K Transcriptional - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 LANLAPFM_02254 1226325.HMPREF1548_01833 1.03e-93 282.0 COG0496@1|root,COG0496@2|Bacteria,1TS2T@1239|Firmicutes,24BI5@186801|Clostridia,36F35@31979|Clostridiaceae 186801|Clostridia S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE LANLAPFM_02255 1430331.EP10_03905 2.16e-75 241.0 COG0827@1|root,COG0827@2|Bacteria,1UZYA@1239|Firmicutes 1239|Firmicutes L BsuBI/PstI restriction endonuclease C-terminus - - - - - - - - - - - - BsuBI_PstI_RE LANLAPFM_02256 622312.ROSEINA2194_00293 9.74e-38 127.0 COG1925@1|root,COG1925@2|Bacteria,1VEJ5@1239|Firmicutes,24R2F@186801|Clostridia 186801|Clostridia G Psort location Cytoplasmic, score - - - - - - - - - - - - PTS-HPr LANLAPFM_02257 585394.RHOM_05135 0.0 1204.0 COG1199@1|root,COG1199@2|Bacteria,1TPNB@1239|Firmicutes,248ZI@186801|Clostridia 186801|Clostridia L helicase dinG - 3.1.12.1,3.6.4.12 ko:K07464,ko:K10844 ko03022,ko03420,map03022,map03420 M00290 - - ko00000,ko00001,ko00002,ko01000,ko02048,ko03021,ko03400 - - - DEAD,DEAD_2,HBB,Helicase_C_2,PDDEXK_1 LANLAPFM_02258 622312.ROSEINA2194_01402 8.35e-199 552.0 COG0583@1|root,COG0583@2|Bacteria,1TRJK@1239|Firmicutes,24AY4@186801|Clostridia 186801|Clostridia K lysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate LANLAPFM_02259 585394.RHOM_05145 0.0 2250.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1TPAS@1239|Firmicutes,247W2@186801|Clostridia 186801|Clostridia F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,GATase_5 LANLAPFM_02261 411459.RUMOBE_00681 9.93e-151 429.0 COG3177@1|root,COG3177@2|Bacteria,1TZWX@1239|Firmicutes,247MZ@186801|Clostridia,3Y0W4@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Fic LANLAPFM_02262 1226325.HMPREF1548_01463 1.65e-17 83.6 COG4637@1|root,COG4637@2|Bacteria,1TQ9X@1239|Firmicutes,247NI@186801|Clostridia,36E5J@31979|Clostridiaceae 186801|Clostridia K An automated process has identified a potential problem with this gene model - - - - - - - - - - - - AAA-ATPase_like,PDDEXK_9 LANLAPFM_02263 1226325.HMPREF1548_01463 9.32e-43 156.0 COG4637@1|root,COG4637@2|Bacteria,1TQ9X@1239|Firmicutes,247NI@186801|Clostridia,36E5J@31979|Clostridiaceae 186801|Clostridia K An automated process has identified a potential problem with this gene model - - - - - - - - - - - - AAA-ATPase_like,PDDEXK_9 LANLAPFM_02264 1519439.JPJG01000008_gene1174 1.25e-68 214.0 2CBD1@1|root,32SNG@2|Bacteria,1VAVB@1239|Firmicutes,24Q8B@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02265 428125.CLOLEP_02050 8.61e-196 558.0 COG1696@1|root,COG1696@2|Bacteria,1TP52@1239|Firmicutes,248V4@186801|Clostridia,3WH3T@541000|Ruminococcaceae 186801|Clostridia M Psort location CytoplasmicMembrane, score - - - ko:K19294 - - - - ko00000 - - - MBOAT LANLAPFM_02266 1304866.K413DRAFT_4421 7.85e-120 358.0 28IAA@1|root,2Z8CW@2|Bacteria,1TQHP@1239|Firmicutes,248TG@186801|Clostridia,36F51@31979|Clostridiaceae 186801|Clostridia S DHHW protein - - - - - - - - - - - - DHHW LANLAPFM_02267 585394.RHOM_05155 4.85e-155 439.0 COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia 186801|Clostridia E Histidinol phosphate phosphatase, HisJ family hisK - 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PHP LANLAPFM_02268 585394.RHOM_01235 0.0 908.0 COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia 186801|Clostridia G Alpha amylase catalytic - - 3.2.1.1,3.2.1.10 ko:K01176,ko:K01182 ko00052,ko00500,ko01100,ko04973,map00052,map00500,map01100,map04973 - R00801,R01718,R01791,R02108,R02112,R06199,R11262 RC00028,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3459 LANLAPFM_02269 742738.HMPREF9460_03797 2.42e-220 627.0 COG1283@1|root,COG1283@2|Bacteria,1TP4K@1239|Firmicutes,247KT@186801|Clostridia,2681R@186813|unclassified Clostridiales 186801|Clostridia P Na+/Pi-cotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU LANLAPFM_02270 622312.ROSEINA2194_01931 7.45e-157 441.0 COG0692@1|root,COG0692@2|Bacteria,1TPSN@1239|Firmicutes,247N9@186801|Clostridia 186801|Clostridia L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung - 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG LANLAPFM_02271 622312.ROSEINA2194_01932 1.87e-170 477.0 COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,24900@186801|Clostridia 186801|Clostridia E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF - - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth LANLAPFM_02272 622312.ROSEINA2194_01933 2.16e-116 336.0 COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia 186801|Clostridia E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase LANLAPFM_02273 622312.ROSEINA2194_01934 3.23e-43 166.0 2DM0G@1|root,31677@2|Bacteria,1UIGR@1239|Firmicutes,25EN6@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02274 585394.RHOM_11275 3.8e-199 553.0 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1TRJU@1239|Firmicutes,24AQW@186801|Clostridia 186801|Clostridia T response regulator receiver cheV - 2.7.13.3 ko:K03407,ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,Response_reg LANLAPFM_02276 1235790.C805_02256 1.08e-26 110.0 2C0VN@1|root,32VTP@2|Bacteria,1VAWW@1239|Firmicutes,24N54@186801|Clostridia,25XSI@186806|Eubacteriaceae 186801|Clostridia - - - - - - - - - - - - - - DUF4352 LANLAPFM_02277 622312.ROSEINA2194_01937 1.78e-252 706.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA LANLAPFM_02278 1235802.C823_02421 2.69e-136 389.0 COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,2484X@186801|Clostridia,25UU1@186806|Eubacteriaceae 186801|Clostridia K Psort location Cytoplasmic, score srrA_6 - - - - - - - - - - - Response_reg,Trans_reg_C LANLAPFM_02279 622312.ROSEINA2194_01939 6.29e-53 176.0 2DSWH@1|root,32UTX@2|Bacteria,1VBEP@1239|Firmicutes,24PR0@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02280 1469948.JPNB01000001_gene964 3.58e-250 694.0 COG1501@1|root,COG1501@2|Bacteria,1UJ1V@1239|Firmicutes,24AVU@186801|Clostridia,36HI8@31979|Clostridiaceae 186801|Clostridia G Alpha galactosidase A - - - - - - - - - - - - Melibiase_2 LANLAPFM_02281 1469948.JPNB01000002_gene3625 0.0 1011.0 COG3533@1|root,COG3533@2|Bacteria,1TNYA@1239|Firmicutes,24841@186801|Clostridia,36FIY@31979|Clostridiaceae 186801|Clostridia S Beta-L-arabinofuranosidase, GH127 - - - ko:K09955 - - - - ko00000 - - - Glyco_hydro_127 LANLAPFM_02282 1469948.JPNB01000002_gene3623 5.14e-19 89.7 COG3507@1|root,COG5492@1|root,COG3507@2|Bacteria,COG5492@2|Bacteria 2|Bacteria N domain, Protein - - - - - - - - - - - - Big_4,Glyco_hydro_43,Laminin_G_3 LANLAPFM_02283 1469948.JPNB01000002_gene3621 0.0 962.0 COG1874@1|root,COG1874@2|Bacteria,1TSHK@1239|Firmicutes,249IJ@186801|Clostridia,36E91@31979|Clostridiaceae 186801|Clostridia G Glycosyl hydrolases family 35 - - 3.2.1.23 ko:K12308 ko00052,map00052 - R01105 RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_35 LANLAPFM_02284 397288.C806_01728 0.0 1024.0 COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,247Z3@186801|Clostridia,27J8N@186928|unclassified Lachnospiraceae 186801|Clostridia J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon LANLAPFM_02285 585394.RHOM_11610 9.58e-271 744.0 COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia 186801|Clostridia J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His LANLAPFM_02286 537007.BLAHAN_06184 7.02e-184 513.0 COG2207@1|root,COG2207@2|Bacteria,1TXIY@1239|Firmicutes,248D1@186801|Clostridia,3Y2AU@572511|Blautia 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18 LANLAPFM_02287 742735.HMPREF9467_01431 4.02e-36 131.0 COG0517@1|root,COG0517@2|Bacteria,1TQ4J@1239|Firmicutes,24B68@186801|Clostridia 186801|Clostridia S Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 LANLAPFM_02288 411471.SUBVAR_04801 0.0 912.0 COG3250@1|root,COG3250@2|Bacteria,1TPK7@1239|Firmicutes,247VE@186801|Clostridia,3WH2X@541000|Ruminococcaceae 186801|Clostridia G Belongs to the glycosyl hydrolase 2 family - - - - - - - - - - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N LANLAPFM_02289 1274374.CBLK010000070_gene1204 8.44e-234 698.0 COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,4HB2V@91061|Bacilli,26SFU@186822|Paenibacillaceae 1239|Firmicutes G Alpha-mannosidase - - - - - - - - - - - - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C LANLAPFM_02291 1298920.KI911353_gene1797 3.04e-134 389.0 COG0395@1|root,COG0395@2|Bacteria,1V2Q1@1239|Firmicutes,24A8E@186801|Clostridia,2202Q@1506553|Lachnoclostridium 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 LANLAPFM_02292 610130.Closa_1668 1.23e-135 394.0 COG1175@1|root,COG1175@2|Bacteria,1V0JI@1239|Firmicutes,25C5R@186801|Clostridia,2200H@1506553|Lachnoclostridium 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 LANLAPFM_02293 1298920.KI911353_gene1795 8.45e-170 493.0 COG1653@1|root,COG1653@2|Bacteria,1V5R7@1239|Firmicutes,25BSW@186801|Clostridia,221PP@1506553|Lachnoclostridium 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_8 LANLAPFM_02294 697281.Mahau_2735 3.3e-43 169.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TV2J@1239|Firmicutes,249HW@186801|Clostridia,42J1B@68295|Thermoanaerobacterales 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg LANLAPFM_02295 1298920.KI911353_gene1794 3.25e-76 261.0 COG2972@1|root,COG2972@2|Bacteria,1VS0D@1239|Firmicutes,24YHS@186801|Clostridia,221U8@1506553|Lachnoclostridium 186801|Clostridia T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,His_kinase LANLAPFM_02296 1226325.HMPREF1548_02292 1.37e-237 680.0 COG3534@1|root,COG3534@2|Bacteria,1TPG2@1239|Firmicutes,24AVP@186801|Clostridia 186801|Clostridia G Alpha-L-arabinofuranosidase C-terminus - - - - - - - - - - - - Alpha-L-AF_C,CBM_4_9,Cadherin-like,Laminin_G_3 LANLAPFM_02297 1232449.BAHV02000002_gene85 2.36e-146 454.0 COG5002@1|root,COG5002@2|Bacteria,1UM03@1239|Firmicutes,24F2S@186801|Clostridia,26CT2@186813|unclassified Clostridiales 186801|Clostridia T GHKL domain - - - - - - - - - - - - HATPase_c,HisKA LANLAPFM_02298 1226325.HMPREF1548_06783 1.2e-131 377.0 COG0745@1|root,COG0745@2|Bacteria,1TP9M@1239|Firmicutes,247TK@186801|Clostridia,36DZG@31979|Clostridiaceae 186801|Clostridia T response regulator, receiver - - - - - - - - - - - - Response_reg,Trans_reg_C LANLAPFM_02299 1410638.JHXJ01000022_gene2268 2.43e-35 128.0 COG1533@1|root,COG1533@2|Bacteria,1TSS2@1239|Firmicutes,248SB@186801|Clostridia,3WH7N@541000|Ruminococcaceae 186801|Clostridia L Radical SAM domain protein - - - - - - - - - - - - Radical_SAM LANLAPFM_02300 585394.RHOM_07130 9.28e-294 810.0 COG0589@1|root,COG0589@2|Bacteria,1TPUI@1239|Firmicutes,24826@186801|Clostridia 186801|Clostridia T Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF1538 LANLAPFM_02301 585394.RHOM_07125 1.79e-110 323.0 COG0347@1|root,COG0347@2|Bacteria,1V65X@1239|Firmicutes,24HQ8@186801|Clostridia 186801|Clostridia E Belongs to the P(II) protein family - - - - - - - - - - - - - LANLAPFM_02302 585394.RHOM_08460 2.44e-234 660.0 COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia 186801|Clostridia J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 LANLAPFM_02303 622312.ROSEINA2194_03969 9.64e-167 476.0 COG3290@1|root,COG3290@2|Bacteria,1V46S@1239|Firmicutes,24KBY@186801|Clostridia 186801|Clostridia T Psort location CytoplasmicMembrane, score - - - - - - - - - - - - HATPase_c_5 LANLAPFM_02305 622312.ROSEINA2194_03971 1.46e-89 266.0 COG4512@1|root,COG4512@2|Bacteria 2|Bacteria KOT PFAM Accessory gene regulator B - - - ko:K07813 ko02020,ko02024,map02020,map02024 - - - ko00000,ko00001,ko01002 - - - AgrB LANLAPFM_02306 622312.ROSEINA2194_03463 0.0 882.0 COG0175@1|root,COG1149@1|root,COG5270@1|root,COG0175@2|Bacteria,COG1149@2|Bacteria,COG5270@2|Bacteria,1TSMI@1239|Firmicutes,24A18@186801|Clostridia 186801|Clostridia EH Phosphoadenosine phosphosulfate reductase - - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - Fer4_7,PAPS_reduct LANLAPFM_02307 622312.ROSEINA2194_03462 1.7e-118 348.0 28MTH@1|root,2ZB1P@2|Bacteria,1UYJE@1239|Firmicutes,24D9M@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF4007) - - - - - - - - - - - - DUF4007 LANLAPFM_02308 622312.ROSEINA2194_03461 0.0 1220.0 COG0262@1|root,COG0262@2|Bacteria,1UIN4@1239|Firmicutes,25ENR@186801|Clostridia 186801|Clostridia H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis - - - - - - - - - - - - - LANLAPFM_02309 622312.ROSEINA2194_03460 3.88e-168 482.0 COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,249CS@186801|Clostridia 186801|Clostridia E Cysteine desulfurase - - - - - - - - - - - - Aminotran_5 LANLAPFM_02310 97139.C824_00955 2.14e-284 803.0 COG1479@1|root,COG3472@1|root,COG1479@2|Bacteria,COG3472@2|Bacteria,1U5K1@1239|Firmicutes,24A01@186801|Clostridia,36I99@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function DUF262 - - - - - - - - - - - - DUF262 LANLAPFM_02312 622312.ROSEINA2194_03457 5.08e-309 862.0 COG0419@1|root,COG0419@2|Bacteria,1TTBF@1239|Firmicutes,24CKY@186801|Clostridia 186801|Clostridia L DNA sulfur modification protein DndD - - - ko:K19171 - - - - ko00000,ko02048 - - - AAA_23 LANLAPFM_02313 1235790.C805_02970 1.67e-76 233.0 2E30B@1|root,32SUY@2|Bacteria,1UPTA@1239|Firmicutes,24T23@186801|Clostridia,25YY1@186806|Eubacteriaceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02314 622312.ROSEINA2194_03455 0.0 1513.0 COG3513@1|root,COG3513@2|Bacteria,1TPSD@1239|Firmicutes,249YY@186801|Clostridia 186801|Clostridia L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer cas9 - - ko:K09952 - - - - ko00000,ko01000,ko02048 - - - HNH_4 LANLAPFM_02315 622312.ROSEINA2194_03454 1.52e-177 499.0 COG1518@1|root,COG1518@2|Bacteria,1TT0J@1239|Firmicutes,24CB1@186801|Clostridia 186801|Clostridia L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas1 - - ko:K15342 - - - - ko00000,ko02048,ko03400 - - - Cas_Cas1 LANLAPFM_02316 622312.ROSEINA2194_03453 2.91e-51 163.0 COG3512@1|root,COG3512@2|Bacteria,1VEH4@1239|Firmicutes,24N00@186801|Clostridia 186801|Clostridia L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas2 - - ko:K09951 - - - - ko00000,ko02048 - - - CRISPR_Cas2 LANLAPFM_02318 585394.RHOM_12465 7e-221 611.0 COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia 186801|Clostridia D Cell shape determining protein, MreB Mrl family mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl LANLAPFM_02319 585394.RHOM_12460 8.36e-152 431.0 COG4786@1|root,COG4786@2|Bacteria,1TRFQ@1239|Firmicutes,24C2V@186801|Clostridia 186801|Clostridia N basal body rod protein flgG - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C LANLAPFM_02320 585394.RHOM_12455 1.11e-139 400.0 COG4786@1|root,COG4786@2|Bacteria,1TT5Z@1239|Firmicutes,248M9@186801|Clostridia 186801|Clostridia N basal body rod protein flgG - - ko:K02390,ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C LANLAPFM_02321 622312.ROSEINA2194_03005 1.33e-36 127.0 COG3951@1|root,COG3951@2|Bacteria,1VICK@1239|Firmicutes,24QXM@186801|Clostridia 186801|Clostridia MNO Flagellar rod assembly protein muramidase FlgJ - - - - - - - - - - - - Rod-binding LANLAPFM_02322 585394.RHOM_12445 0.0 1268.0 COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,247R7@186801|Clostridia 186801|Clostridia L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 LANLAPFM_02323 622312.ROSEINA2194_02621 1.41e-172 483.0 COG1101@1|root,COG1101@2|Bacteria,1TPAN@1239|Firmicutes,247WW@186801|Clostridia 186801|Clostridia S Abc transporter - - - ko:K05833 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_tran LANLAPFM_02324 585394.RHOM_12435 6.4e-192 536.0 COG4120@1|root,COG4120@2|Bacteria,1TPDJ@1239|Firmicutes,249P1@186801|Clostridia 186801|Clostridia S Belongs to the binding-protein-dependent transport system permease family - - - ko:K05832 - M00247 - - ko00000,ko00002,ko02000 - - - BPD_transp_2 LANLAPFM_02325 622312.ROSEINA2194_02619 9.76e-177 501.0 COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,248X3@186801|Clostridia 186801|Clostridia S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind LANLAPFM_02326 622312.ROSEINA2194_02618 1.29e-76 239.0 COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia 186801|Clostridia S ComF family comF - - ko:K02242 - M00429 - - ko00000,ko00002,ko02044 - - - Pribosyltran LANLAPFM_02327 585394.RHOM_12420 7.79e-65 200.0 2D61I@1|root,32TKA@2|Bacteria,1VB5H@1239|Firmicutes,24NZW@186801|Clostridia 186801|Clostridia N TIGRFAM flagellar operon protein yvyF - - - - - - - - - - - - LANLAPFM_02328 585394.RHOM_12415 1.1e-50 165.0 2DIZ6@1|root,32UC0@2|Bacteria,1VCGW@1239|Firmicutes,24Q40@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02329 585394.RHOM_12410 1.42e-163 466.0 28K89@1|root,2Z9W3@2|Bacteria,1V1PZ@1239|Firmicutes,24D2W@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - LANLAPFM_02330 585394.RHOM_12405 9.81e-166 469.0 COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,249K8@186801|Clostridia 186801|Clostridia S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA - 2.7.7.85 ko:K18672 - - - - ko00000,ko01000 - - - DisA_N LANLAPFM_02331 585394.RHOM_12400 3.51e-145 429.0 COG4856@1|root,COG4856@2|Bacteria,1UZEV@1239|Firmicutes,25CGI@186801|Clostridia 186801|Clostridia S protein conserved in bacteria - - - - - - - - - - - - YbbR LANLAPFM_02332 622312.ROSEINA2194_02611 4.67e-297 813.0 COG1109@1|root,COG1109@2|Bacteria,1TP1X@1239|Firmicutes,2499P@186801|Clostridia 186801|Clostridia G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV LANLAPFM_02333 585394.RHOM_12390 6.68e-52 164.0 COG1925@1|root,COG1925@2|Bacteria,1VA23@1239|Firmicutes,24N32@186801|Clostridia 186801|Clostridia G Psort location Cytoplasmic, score - - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr LANLAPFM_02334 585394.RHOM_12385 2.05e-179 503.0 COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,247PG@186801|Clostridia 186801|Clostridia M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind LANLAPFM_02335 585394.RHOM_12380 3.49e-140 422.0 2AJ90@1|root,319TX@2|Bacteria,1VFA5@1239|Firmicutes,25DCM@186801|Clostridia 186801|Clostridia S Glucosyl transferase GtrII - - - - - - - - - - - - Glucos_trans_II LANLAPFM_02336 585394.RHOM_12375 5.63e-253 694.0 COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,247NE@186801|Clostridia 186801|Clostridia M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd LANLAPFM_02337 585394.RHOM_12370 4.32e-200 555.0 COG1209@1|root,COG1209@2|Bacteria,1V301@1239|Firmicutes,247XE@186801|Clostridia 186801|Clostridia M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase LANLAPFM_02338 585394.RHOM_12365 2.17e-126 360.0 COG1898@1|root,COG1898@2|Bacteria,1TRVB@1239|Firmicutes,248VX@186801|Clostridia 186801|Clostridia M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS02630,iHN637.CLJU_RS02745 dTDP_sugar_isom LANLAPFM_02339 585394.RHOM_12360 2.75e-138 397.0 COG1682@1|root,COG1682@2|Bacteria,1TQZF@1239|Firmicutes,248R0@186801|Clostridia 186801|Clostridia GM Transport permease protein - - - ko:K09692 ko02010,map02010 M00251 - - ko00000,ko00001,ko00002,ko02000 3.A.1.104 - - ABC2_membrane LANLAPFM_02340 585394.RHOM_12355 6.56e-264 728.0 COG1134@1|root,COG1134@2|Bacteria,1TQKK@1239|Firmicutes,24A5V@186801|Clostridia 186801|Clostridia GM ABC-type polysaccharide polyol phosphate transport system ATPase component - - 3.6.3.40 ko:K01990,ko:K09691,ko:K09693 ko02010,map02010 M00250,M00251,M00254 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.103,3.A.1.104 - - ABC_tran,Wzt_C LANLAPFM_02341 1235790.C805_00459 4.3e-103 337.0 COG2242@1|root,COG2242@2|Bacteria,1TPEE@1239|Firmicutes,24D9B@186801|Clostridia,25Y5N@186806|Eubacteriaceae 186801|Clostridia H Methyltransferase domain - - - - - - - - - - - - Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25 LANLAPFM_02342 585394.RHOM_12340 8.8e-282 777.0 COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,24870@186801|Clostridia 186801|Clostridia M sugar transferase - - - - - - - - - - - - Bac_transf,CoA_binding_3 LANLAPFM_02343 585394.RHOM_12335 7.82e-108 332.0 COG0489@1|root,COG3944@1|root,COG0489@2|Bacteria,COG3944@2|Bacteria 2|Bacteria M capsule polysaccharide biosynthetic process wzc - 2.7.10.1,2.7.10.2 ko:K08252,ko:K08253,ko:K16692 - - - - ko00000,ko01000,ko01001 - - - AAA_31,CbiA,GNVR,ParA,Wzz LANLAPFM_02344 585394.RHOM_12330 6.43e-121 360.0 2A542@1|root,30TSQ@2|Bacteria,1V4Q2@1239|Firmicutes,24ISW@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02347 585394.RHOM_12310 9.01e-226 629.0 COG0438@1|root,COG0438@2|Bacteria,1V0JW@1239|Firmicutes,24CKB@186801|Clostridia 186801|Clostridia M Glycosyltransferase, group 1 family protein - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 LANLAPFM_02348 585394.RHOM_12305 1.1e-197 555.0 COG0438@1|root,COG0438@2|Bacteria,1UI11@1239|Firmicutes,24CV8@186801|Clostridia 186801|Clostridia M Glycosyltransferase, group 1 family protein - - - - - - - - - - - - Glyco_trans_4_2,Glycos_transf_1 LANLAPFM_02349 585394.RHOM_12300 1.88e-210 589.0 COG0438@1|root,COG0438@2|Bacteria,1VE1G@1239|Firmicutes 1239|Firmicutes M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 LANLAPFM_02350 585394.RHOM_12295 9.18e-172 484.0 COG0451@1|root,COG0451@2|Bacteria,1V34Y@1239|Firmicutes,25EDZ@186801|Clostridia 186801|Clostridia M 3-beta hydroxysteroid dehydrogenase/isomerase family - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase LANLAPFM_02351 585394.RHOM_12290 6.03e-153 437.0 COG1216@1|root,COG1216@2|Bacteria,1UD0A@1239|Firmicutes,24GXB@186801|Clostridia 186801|Clostridia S Glycosyl transferase, family 2 - - - - - - - - - - - - GNT-I,Glycos_transf_2 LANLAPFM_02352 585394.RHOM_12285 1.58e-150 428.0 COG1216@1|root,COG1216@2|Bacteria,1VBWR@1239|Firmicutes,24NB1@186801|Clostridia 186801|Clostridia S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 LANLAPFM_02353 585394.RHOM_12280 6.49e-134 389.0 COG1216@1|root,COG1216@2|Bacteria,1VAHM@1239|Firmicutes,24MBF@186801|Clostridia 186801|Clostridia S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 LANLAPFM_02355 1294142.CINTURNW_0481 2.32e-95 304.0 COG2244@1|root,COG2244@2|Bacteria,1TP7R@1239|Firmicutes,24AD0@186801|Clostridia,36EMQ@31979|Clostridiaceae 186801|Clostridia S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_C LANLAPFM_02357 1280671.AUJH01000019_gene2337 3.11e-10 67.4 2CJWU@1|root,32SAY@2|Bacteria,1V3P4@1239|Firmicutes,24SCQ@186801|Clostridia,4C0ZT@830|Butyrivibrio 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02360 397290.C810_03895 1.06e-29 136.0 COG4193@1|root,COG5492@1|root,COG4193@2|Bacteria,COG5492@2|Bacteria,1TRTM@1239|Firmicutes,24C4N@186801|Clostridia,27K3Z@186928|unclassified Lachnospiraceae 186801|Clostridia G SH3 domain protein - - - - - - - - - - - - Big_2,Cadherin-like,Dockerin_1,Glucosaminidase,SH3_3 LANLAPFM_02361 397290.C810_03894 1.7e-183 582.0 COG0860@1|root,COG4733@1|root,COG0860@2|Bacteria,COG4733@2|Bacteria,1UZ49@1239|Firmicutes,25F7R@186801|Clostridia,27JMX@186928|unclassified Lachnospiraceae 186801|Clostridia M N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3,Big_2,GBS_Bsp-like,Glucosaminidase,RicinB_lectin_2,fn3 LANLAPFM_02363 585394.RHOM_12250 5.47e-203 576.0 COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,248WV@186801|Clostridia 186801|Clostridia M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase - - - - - - - - - - - - Bac_transf LANLAPFM_02364 1151292.QEW_3393 6.99e-70 222.0 COG1215@1|root,COG1215@2|Bacteria,1VUUB@1239|Firmicutes,25EXJ@186801|Clostridia,25RVG@186804|Peptostreptococcaceae 186801|Clostridia M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 LANLAPFM_02365 397288.C806_01846 3.12e-199 562.0 COG1887@1|root,COG1887@2|Bacteria,1V4DT@1239|Firmicutes,24EWQ@186801|Clostridia,27P24@186928|unclassified Lachnospiraceae 186801|Clostridia M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase - - - - - - - - - - - - Glyphos_transf LANLAPFM_02366 1235790.C805_00463 3.6e-109 322.0 COG1682@1|root,COG1682@2|Bacteria,1UZ1K@1239|Firmicutes,24DBF@186801|Clostridia,25UVJ@186806|Eubacteriaceae 186801|Clostridia U ABC-2 type transporter - - - ko:K09692 ko02010,map02010 M00251 - - ko00000,ko00001,ko00002,ko02000 3.A.1.104 - - ABC2_membrane LANLAPFM_02367 1235790.C805_00464 1.09e-122 355.0 COG1134@1|root,COG1134@2|Bacteria,1TQKK@1239|Firmicutes,24A5V@186801|Clostridia,25VYR@186806|Eubacteriaceae 186801|Clostridia GM ATPases associated with a variety of cellular activities - - 3.6.3.40 ko:K09693 ko02010,map02010 M00251 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.104 - - ABC_tran LANLAPFM_02368 1123300.AUIN01000009_gene103 5.08e-51 175.0 COG3475@1|root,COG3475@2|Bacteria,1TS3X@1239|Firmicutes 1239|Firmicutes M LicD family - - - ko:K07271 - - - - ko00000,ko01000 - - - LicD LANLAPFM_02369 999415.HMPREF9943_00340 4.05e-110 323.0 COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,3VRB7@526524|Erysipelotrichia 526524|Erysipelotrichia I Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate - - - - - - - - - - - - IspD LANLAPFM_02370 1286171.EAL2_c19010 2.14e-97 300.0 COG0451@1|root,COG0451@2|Bacteria,1TS59@1239|Firmicutes,247JP@186801|Clostridia,25W52@186806|Eubacteriaceae 186801|Clostridia GM NAD dependent epimerase dehydratase family - - - - - - - - - - - - Epimerase LANLAPFM_02371 697329.Rumal_2993 9.92e-102 315.0 COG1887@1|root,COG1887@2|Bacteria,1TP75@1239|Firmicutes,24ED0@186801|Clostridia,3WKZI@541000|Ruminococcaceae 186801|Clostridia M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase - - 2.7.8.12 ko:K09809 - - - - ko00000,ko01000 - - - Glyphos_transf LANLAPFM_02372 397288.C806_01840 1.35e-36 154.0 COG1368@1|root,COG1368@2|Bacteria,1VI7Z@1239|Firmicutes,24QYG@186801|Clostridia,27PIR@186928|unclassified Lachnospiraceae 186801|Clostridia M Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - Wzy_C LANLAPFM_02374 398512.JQKC01000009_gene393 1.02e-91 284.0 COG0464@1|root,COG0464@2|Bacteria,1TSG1@1239|Firmicutes,24CWS@186801|Clostridia,3WQ3K@541000|Ruminococcaceae 186801|Clostridia O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA LANLAPFM_02375 657322.FPR_08500 8.49e-39 130.0 2CZEX@1|root,32T68@2|Bacteria,1VB18@1239|Firmicutes,24MZP@186801|Clostridia,3WPUQ@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02376 585394.RHOM_04860 5.46e-62 195.0 COG1846@1|root,COG1846@2|Bacteria,1VEYN@1239|Firmicutes,24S21@186801|Clostridia 186801|Clostridia K Transcriptional regulator, MarR family - - - - - - - - - - - - MarR,MarR_2 LANLAPFM_02377 585394.RHOM_04855 0.0 989.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia 186801|Clostridia V Abc transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_02378 585394.RHOM_04850 0.0 1155.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_02379 585394.RHOM_04845 3.53e-63 199.0 COG1418@1|root,COG1418@2|Bacteria,1V4QX@1239|Firmicutes,24JBS@186801|Clostridia 186801|Clostridia S HD superfamily hydrolase - - - ko:K06950 - - - - ko00000 - - - HD LANLAPFM_02380 585394.RHOM_10060 6.9e-315 861.0 COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia 186801|Clostridia J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey LANLAPFM_02381 622312.ROSEINA2194_00798 8.43e-314 859.0 COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia 186801|Clostridia J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase LANLAPFM_02382 585394.RHOM_10070 4.76e-130 379.0 COG0721@1|root,COG1670@1|root,COG0721@2|Bacteria,COG1670@2|Bacteria,1V6E0@1239|Firmicutes,24G2M@186801|Clostridia 186801|Clostridia J acetyltransferase, GNAT family - - 2.3.1.128 ko:K03790 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 LANLAPFM_02383 622312.ROSEINA2194_00796 4.85e-296 810.0 COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,248XN@186801|Clostridia 186801|Clostridia J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12,6.1.1.23 ko:K01876,ko:K09759 ko00970,map00970 M00359,M00360 R03647,R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - tRNA-synt_2,tRNA_anti-codon LANLAPFM_02384 140626.JHWB01000013_gene770 0.0 1090.0 COG0366@1|root,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 13 family - - - - - - - - - - - - AMPK1_CBM,Alpha-amylase,Alpha-amylase_N,Big_2,CBM_20,CBM_48,Cadherin-like,Malt_amylase_C,PUD,SLH LANLAPFM_02385 622312.ROSEINA2194_02462 2.45e-134 386.0 COG2966@1|root,COG2966@2|Bacteria,1TSE8@1239|Firmicutes,24A25@186801|Clostridia 186801|Clostridia K Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Acetyltransf_7,ThrE LANLAPFM_02386 585394.RHOM_03645 2.61e-72 220.0 COG3610@1|root,COG3610@2|Bacteria,1V6P0@1239|Firmicutes,24R80@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - ThrE_2 LANLAPFM_02387 1410618.JNKI01000001_gene1495 9.28e-34 138.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1U4YK@1239|Firmicutes,4H6FE@909932|Negativicutes 909932|Negativicutes T PAS fold - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,Response_reg LANLAPFM_02389 666681.M301_0409 3.2e-21 106.0 COG3850@1|root,COG5001@1|root,COG3850@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VKCJ@28216|Betaproteobacteria,2KKKT@206350|Nitrosomonadales 206350|Nitrosomonadales T Periplasmic sensor domain - - - - - - - - - - - - CHASE8,EAL,GGDEF,HAMP LANLAPFM_02390 585394.RHOM_03640 8.04e-290 811.0 COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247Q9@186801|Clostridia 186801|Clostridia S Abc transporter yfmR - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn LANLAPFM_02391 622312.ROSEINA2194_00341 0.0 942.0 COG4868@1|root,COG4868@2|Bacteria,1TQYE@1239|Firmicutes,247YI@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF1846 LANLAPFM_02392 411489.CLOL250_02693 1.73e-154 466.0 COG5492@1|root,COG5492@2|Bacteria 2|Bacteria N domain, Protein - - 3.2.1.41 ko:K01200 ko00500,ko01100,ko01110,map00500,map01100,map01110 - R02111 - ko00000,ko00001,ko01000 - CBM48,GH13 - AMPK1_CBM,Alpha-amylase,Big_2,Big_5,CBM_48,Flg_new,Gram_pos_anchor,PUD,SLH LANLAPFM_02393 1121344.JHZO01000003_gene939 1.93e-59 190.0 COG1704@1|root,COG1704@2|Bacteria,1V3Z0@1239|Firmicutes,24IH4@186801|Clostridia,3WM16@541000|Ruminococcaceae 186801|Clostridia S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA LANLAPFM_02395 1007096.BAGW01000014_gene1156 1.07e-77 254.0 COG3290@1|root,COG3290@2|Bacteria,1TS6E@1239|Firmicutes,24DDI@186801|Clostridia 186801|Clostridia T GHKL domain - - - - - - - - - - - - HATPase_c_5 LANLAPFM_02396 622312.ROSEINA2194_00344 5.75e-131 376.0 COG3279@1|root,COG3279@2|Bacteria,1TSDB@1239|Firmicutes,24MQ4@186801|Clostridia 186801|Clostridia KT response regulator - - - - - - - - - - - - LytTR,Response_reg LANLAPFM_02397 585394.RHOM_03635 8.21e-236 674.0 COG2200@1|root,COG2200@2|Bacteria,1TQRN@1239|Firmicutes,247QG@186801|Clostridia 186801|Clostridia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF LANLAPFM_02398 622312.ROSEINA2194_02467 9.5e-142 402.0 COG2357@1|root,COG2357@2|Bacteria,1TSC9@1239|Firmicutes,25CET@186801|Clostridia 186801|Clostridia S RelA SpoT domain protein spoT - 2.7.6.5 ko:K07816 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - RelA_SpoT LANLAPFM_02399 537007.BLAHAN_06528 2.53e-192 540.0 COG3641@1|root,COG3641@2|Bacteria,1TS5F@1239|Firmicutes,247P0@186801|Clostridia,3XZ5V@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - ko:K07035 - - - - ko00000 - - - PTS_EIIC_2 LANLAPFM_02400 1064535.MELS_0830 4.14e-25 106.0 292FV@1|root,2ZQ01@2|Bacteria,1V62Q@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - LANLAPFM_02401 1050201.KB913034_gene1211 1.48e-41 148.0 COG1106@1|root,COG1106@2|Bacteria,1TSBY@1239|Firmicutes,3VQQ1@526524|Erysipelotrichia 526524|Erysipelotrichia S AAA domain, putative AbiEii toxin, Type IV TA system - - - - - - - - - - - - AAA_21 LANLAPFM_02402 585394.RHOM_11125 4.48e-44 159.0 2E4NI@1|root,32ZHC@2|Bacteria,1VGQR@1239|Firmicutes,24RYT@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02403 585394.RHOM_11120 0.0 897.0 COG1227@1|root,COG4109@1|root,COG1227@2|Bacteria,COG4109@2|Bacteria,1TPH6@1239|Firmicutes,248RQ@186801|Clostridia 186801|Clostridia C domain protein ppaC - 3.6.1.1 ko:K15986 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - CBS,DHH,DHHA2,DRTGG LANLAPFM_02404 585394.RHOM_11115 2.25e-146 418.0 COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1UZ8Y@1239|Firmicutes,248SM@186801|Clostridia 186801|Clostridia K transcriptional regulator (AraC family) - - - - - - - - - - - - AraC_binding,HTH_18 LANLAPFM_02405 585394.RHOM_11110 3.46e-271 744.0 COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,25E6I@186801|Clostridia 186801|Clostridia E PFAM Cys Met metabolism mccB - 2.5.1.48,4.4.1.8 ko:K01739,ko:K01760 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP LANLAPFM_02406 585394.RHOM_11105 1.28e-190 530.0 COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia 186801|Clostridia E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase LANLAPFM_02407 622312.ROSEINA2194_04128 4.34e-314 861.0 COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia 186801|Clostridia M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M LANLAPFM_02408 411462.DORLON_00274 4.26e-187 531.0 COG0037@1|root,COG0607@1|root,COG0037@2|Bacteria,COG0607@2|Bacteria,1TQ0Y@1239|Firmicutes,247RP@186801|Clostridia,27VSU@189330|Dorea 186801|Clostridia H ATPase of the PP-loop superfamily implicated in cell cycle control ttcA - - - - - - - - - - - ATP_bind_3,Rhodanese LANLAPFM_02409 642492.Clole_2677 1.85e-314 885.0 COG4447@1|root,COG4447@2|Bacteria,1VJ96@1239|Firmicutes 1239|Firmicutes S cellulose binding - - - - - - - - - - - - - LANLAPFM_02410 642492.Clole_2676 0.0 1200.0 COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,248WR@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 31 family - - 3.2.1.177 ko:K01811 - - - - ko00000,ko01000 - GH31 - DUF5110,Glyco_hydro_31 LANLAPFM_02411 585394.RHOM_04635 0.0 1140.0 COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia 186801|Clostridia M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C LANLAPFM_02412 585394.RHOM_04640 4.3e-216 605.0 COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia 186801|Clostridia H Involved in the biosynthesis of porphyrin-containing compound hemN - - - - - - - - - - - HemN_C,Radical_SAM LANLAPFM_02415 981383.AEWH01000051_gene478 2.8e-72 233.0 28IGH@1|root,2Z8HY@2|Bacteria,1TQX2@1239|Firmicutes,4HA00@91061|Bacilli 91061|Bacilli S Conjugative transposon protein TcpC - - - - - - - - - - - - TpcC LANLAPFM_02417 641107.CDLVIII_5796 4.97e-122 361.0 COG0741@1|root,COG0791@1|root,COG0741@2|Bacteria,COG0791@2|Bacteria,1TP24@1239|Firmicutes,247K5@186801|Clostridia,36H24@31979|Clostridiaceae 186801|Clostridia M NlpC P60 family protein - - - - - - - - - - - - Lysozyme_like,NLPC_P60 LANLAPFM_02418 908340.HMPREF9406_0793 1.15e-143 449.0 COG3064@1|root,COG3064@2|Bacteria,1UIYZ@1239|Firmicutes,249MX@186801|Clostridia,36FMM@31979|Clostridiaceae 186801|Clostridia M Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - LANLAPFM_02419 1158601.I585_00435 0.0 976.0 COG0433@1|root,COG0433@2|Bacteria,1TPVQ@1239|Firmicutes,4HBZY@91061|Bacilli,4B0FA@81852|Enterococcaceae 91061|Bacilli S AAA-like domain - - - - - - - - - - - - AAA_10 LANLAPFM_02420 658659.HMPREF0983_03979 1.48e-37 131.0 28I70@1|root,2Z89W@2|Bacteria,1V1TC@1239|Firmicutes,3VQEW@526524|Erysipelotrichia 1239|Firmicutes S TcpE family - - - - - - - - - - - - TcpE LANLAPFM_02422 1449338.JQLU01000005_gene2736 1.33e-149 441.0 COG3620@1|root,COG3620@2|Bacteria,1TPHQ@1239|Firmicutes,4HCHD@91061|Bacilli 91061|Bacilli K Replication initiation factor - - - ko:K07467 - - - - ko00000 - - - HTH_3,Omega_Repress,Rep_trans LANLAPFM_02424 411461.DORFOR_03093 5.01e-138 411.0 COG1674@1|root,COG1674@2|Bacteria,1TPHE@1239|Firmicutes,249WR@186801|Clostridia,27V96@189330|Dorea 186801|Clostridia D COG COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins - - - - - - - - - - - - DUF87,FtsK_SpoIIIE LANLAPFM_02425 169963.lmo1113 1.27e-34 124.0 28NIV@1|root,2ZBK5@2|Bacteria,1V1U5@1239|Firmicutes,4HG1A@91061|Bacilli 91061|Bacilli S Bacterial protein of unknown function (DUF961) - - - - - - - - - - - - DUF961 LANLAPFM_02426 169963.lmo1114 4.02e-34 120.0 2BXTH@1|root,2ZZ52@2|Bacteria,1V3TU@1239|Firmicutes,4HH9J@91061|Bacilli 91061|Bacilli S Bacterial protein of unknown function (DUF961) - - - - - - - - - - - - DUF961 LANLAPFM_02436 1151292.QEW_4439 6.99e-07 48.9 2ECXB@1|root,336UH@2|Bacteria,1VJWZ@1239|Firmicutes,24UVH@186801|Clostridia 186801|Clostridia K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - HTH_26 LANLAPFM_02437 592026.GCWU0000282_000988 3.11e-34 118.0 COG3514@1|root,COG3514@2|Bacteria,1VFWT@1239|Firmicutes,24S45@186801|Clostridia 186801|Clostridia S BrnA antitoxin of type II toxin-antitoxin system - - - - - - - - - - - - BrnA_antitoxin LANLAPFM_02438 180332.JTGN01000001_gene5293 8.12e-05 52.8 COG5492@1|root,COG5492@2|Bacteria,1TQGW@1239|Firmicutes,25END@186801|Clostridia 186801|Clostridia N Domain of unknown function (DUF4430) - - - - - - - - - - - - Big_2,DUF4430 LANLAPFM_02439 585394.RHOM_06695 7.69e-95 298.0 COG0840@1|root,COG0840@2|Bacteria 2|Bacteria NT transmembrane signaling receptor activity - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,dCache_1,sCache_2 LANLAPFM_02440 622312.ROSEINA2194_03291 0.0 1541.0 COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia 186801|Clostridia J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD LANLAPFM_02442 622312.ROSEINA2194_03293 8.31e-141 402.0 COG2220@1|root,COG2220@2|Bacteria,1V3HY@1239|Firmicutes,24HK9@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score folD4 - - - - - - - - - - - Lactamase_B_3 LANLAPFM_02443 585394.RHOM_06675 4.82e-293 802.0 COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia 186801|Clostridia F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31,3.5.4.40 ko:K12960,ko:K20810 ko00130,ko00270,ko01100,ko01110,map00130,map00270,map01100,map01110 - R09660,R10695 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 LANLAPFM_02444 585394.RHOM_06670 1.36e-163 461.0 COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia 186801|Clostridia F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate punA - 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 LANLAPFM_02445 585394.RHOM_06660 3.08e-59 192.0 2DY6R@1|root,32V4T@2|Bacteria,1VDMI@1239|Firmicutes,24D1Z@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02446 585394.RHOM_06665 1.79e-101 300.0 COG2364@1|root,COG2364@2|Bacteria,1V7N6@1239|Firmicutes,25CWQ@186801|Clostridia 186801|Clostridia S Membrane - - - - - - - - - - - - - LANLAPFM_02447 585394.RHOM_06645 3.35e-267 743.0 COG0699@1|root,COG0699@2|Bacteria,1TPPG@1239|Firmicutes,24829@186801|Clostridia 186801|Clostridia S ATPase. Has a role at an early stage in the morphogenesis of the spore coat spoIVA GO:0000003,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0008144,GO:0008150,GO:0009653,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019954,GO:0030154,GO:0030312,GO:0030435,GO:0030436,GO:0030554,GO:0031160,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0034301,GO:0035639,GO:0036094,GO:0042601,GO:0042763,GO:0043167,GO:0043168,GO:0043934,GO:0043936,GO:0044464,GO:0048646,GO:0048856,GO:0048869,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K06398 - - - - ko00000 - - - Spore_IV_A LANLAPFM_02448 585394.RHOM_06640 7.59e-136 395.0 COG1597@1|root,COG1597@2|Bacteria,1V7DZ@1239|Firmicutes,25CN5@186801|Clostridia 186801|Clostridia I Diacylglycerol kinase catalytic domain ytlR - - - - - - - - - - - DAGK_cat LANLAPFM_02449 622312.ROSEINA2194_01766 6.25e-314 860.0 COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia 186801|Clostridia G 4-alpha-glucanotransferase malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 LANLAPFM_02450 585394.RHOM_06630 1.68e-192 540.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia 186801|Clostridia K Periplasmic binding protein LacI transcriptional regulator - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 LANLAPFM_02451 585394.RHOM_06625 3.01e-178 499.0 COG0395@1|root,COG0395@2|Bacteria,1TR45@1239|Firmicutes,24A48@186801|Clostridia 186801|Clostridia P sugar transport system permease - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 LANLAPFM_02452 622312.ROSEINA2194_01763 7.84e-184 513.0 COG1175@1|root,COG1175@2|Bacteria,1TP1Q@1239|Firmicutes,24ADV@186801|Clostridia 186801|Clostridia P Abc transporter, permease protein - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 LANLAPFM_02453 622312.ROSEINA2194_01762 8.92e-279 770.0 COG1653@1|root,COG1653@2|Bacteria,1TQHT@1239|Firmicutes,249J6@186801|Clostridia 186801|Clostridia G ABC transporter, solute-binding protein amyE - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_8,TAT_signal LANLAPFM_02457 585394.RHOM_08870 0.0 1054.0 COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia 186801|Clostridia L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 LANLAPFM_02458 622312.ROSEINA2194_03392 1.01e-55 180.0 2AE00@1|root,313SJ@2|Bacteria,1V6FJ@1239|Firmicutes,24JFA@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - LANLAPFM_02459 471875.RUMLAC_02590 0.0 916.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247PY@186801|Clostridia,3WHFU@541000|Ruminococcaceae 186801|Clostridia V Psort location CytoplasmicMembrane, score 10.00 - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_02460 411463.EUBVEN_02439 0.0 879.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247VZ@186801|Clostridia,25VCK@186806|Eubacteriaceae 186801|Clostridia P ABC transporter, ATP-binding protein - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_02461 471875.RUMLAC_02592 2.05e-78 240.0 COG1309@1|root,COG1309@2|Bacteria,1TT2J@1239|Firmicutes,24A5X@186801|Clostridia,3WJRA@541000|Ruminococcaceae 186801|Clostridia K tetR family - - - - - - - - - - - - TetR_N LANLAPFM_02462 622312.ROSEINA2194_00853 3.33e-128 365.0 28NMC@1|root,2ZA4G@2|Bacteria,1UYCN@1239|Firmicutes,24ACB@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - GtrA LANLAPFM_02463 622312.ROSEINA2194_00851 0.0 1594.0 COG1472@1|root,COG1472@2|Bacteria,1TPH5@1239|Firmicutes,247QP@186801|Clostridia 186801|Clostridia G Glycosyl hydrolase family 3 N-terminal domain protein - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C LANLAPFM_02464 622312.ROSEINA2194_00850 9.14e-233 650.0 COG3290@1|root,COG3290@2|Bacteria,1TPZT@1239|Firmicutes,2494S@186801|Clostridia 186801|Clostridia T Psort location CytoplasmicMembrane, score - - - - - - - - - - - - HATPase_c_5 LANLAPFM_02465 622312.ROSEINA2194_00849 1.06e-140 400.0 COG3279@1|root,COG3279@2|Bacteria,1UHWR@1239|Firmicutes,24G6Q@186801|Clostridia 186801|Clostridia KT COG3279 Response regulator of the LytR AlgR family - - - ko:K07705 ko02020,map02020 M00492 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg LANLAPFM_02466 622312.ROSEINA2194_04390 0.0 1397.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia 186801|Clostridia G hydrolase, family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C LANLAPFM_02468 796942.HMPREF9623_01507 4.78e-159 465.0 COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,1UHQC@1239|Firmicutes,25EVD@186801|Clostridia 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA LANLAPFM_02469 796942.HMPREF9623_01506 2.35e-118 343.0 COG0745@1|root,COG0745@2|Bacteria,1TS81@1239|Firmicutes,248XH@186801|Clostridia 186801|Clostridia T response regulator receiver mprA - - - - - - - - - - - Response_reg,Trans_reg_C LANLAPFM_02471 622312.ROSEINA2194_04316 1.28e-80 241.0 COG0071@1|root,COG0071@2|Bacteria,1VG0E@1239|Firmicutes,24MRZ@186801|Clostridia 186801|Clostridia O Belongs to the small heat shock protein (HSP20) family hsp18 - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 LANLAPFM_02472 1469948.JPNB01000002_gene3764 3.72e-21 94.0 COG1835@1|root,COG1835@2|Bacteria,1UY2A@1239|Firmicutes,24D38@186801|Clostridia,36IC7@31979|Clostridiaceae 186801|Clostridia I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 LANLAPFM_02473 1235800.C819_01132 1.38e-38 139.0 COG1835@1|root,COG1835@2|Bacteria,1UY2A@1239|Firmicutes,24D38@186801|Clostridia,27IZK@186928|unclassified Lachnospiraceae 186801|Clostridia I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 LANLAPFM_02474 585394.RHOM_09595 1.06e-261 727.0 COG1158@1|root,COG1158@2|Bacteria,1TPHZ@1239|Firmicutes,247YK@186801|Clostridia 186801|Clostridia K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind LANLAPFM_02475 665950.HMPREF1025_00892 2.89e-123 364.0 COG1396@1|root,COG1396@2|Bacteria,1TQZJ@1239|Firmicutes,25E5Y@186801|Clostridia,27IYF@186928|unclassified Lachnospiraceae 186801|Clostridia K Psort location CytoplasmicMembrane, score - - - - - - - - - - - - HTH_3 LANLAPFM_02477 585394.RHOM_08055 0.0 1187.0 COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia 186801|Clostridia J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 LANLAPFM_02478 585394.RHOM_08050 7.88e-268 739.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia 186801|Clostridia V Mate efflux family protein - - - - - - - - - - - - MatE LANLAPFM_02479 622312.ROSEINA2194_01230 0.0 1040.0 COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia 186801|Clostridia J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d LANLAPFM_02480 1235802.C823_05151 3.65e-72 221.0 COG4708@1|root,COG4708@2|Bacteria,1V9YK@1239|Firmicutes,24N9H@186801|Clostridia,25WR7@186806|Eubacteriaceae 186801|Clostridia S QueT transporter queT - - - - - - - - - - - QueT LANLAPFM_02481 622312.ROSEINA2194_02252 1.03e-38 132.0 2ETB0@1|root,33KUX@2|Bacteria,1VPRN@1239|Firmicutes,24WSP@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02482 585394.RHOM_04200 3.65e-114 330.0 COG1896@1|root,COG1896@2|Bacteria,1V3MK@1239|Firmicutes,24IBW@186801|Clostridia 186801|Clostridia D Psort location Cytoplasmic, score 8.87 - - - ko:K07023 - - - - ko00000 - - - HD_3 LANLAPFM_02483 585394.RHOM_04205 0.0 985.0 COG2309@1|root,COG2309@2|Bacteria,1TSPE@1239|Firmicutes,24A6S@186801|Clostridia 186801|Clostridia E Psort location Cytoplasmic, score - - - - - - - - - - - - Peptidase_M29 LANLAPFM_02484 585394.RHOM_04210 1.71e-105 305.0 COG0041@1|root,COG0041@2|Bacteria,1V1MV@1239|Firmicutes,24HCB@186801|Clostridia 186801|Clostridia F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC LANLAPFM_02485 585394.RHOM_04215 8.21e-225 622.0 COG0150@1|root,COG0150@2|Bacteria,1TP9J@1239|Firmicutes,248BT@186801|Clostridia 186801|Clostridia F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C LANLAPFM_02486 585394.RHOM_04220 9.79e-119 342.0 COG0299@1|root,COG0299@2|Bacteria,1V3RJ@1239|Firmicutes,249JC@186801|Clostridia 186801|Clostridia F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS04225 Formyl_trans_N LANLAPFM_02487 585394.RHOM_04225 8.39e-297 811.0 COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia 186801|Clostridia F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N LANLAPFM_02488 585394.RHOM_03875 2.21e-65 201.0 COG1433@1|root,COG1433@2|Bacteria,1V7KS@1239|Firmicutes,24MUB@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - C_GCAxxG_C_C LANLAPFM_02489 585394.RHOM_03880 2e-202 568.0 COG1879@1|root,COG1879@2|Bacteria,1TQW5@1239|Firmicutes,249PS@186801|Clostridia 186801|Clostridia G ABC-type sugar transport system periplasmic component - - - ko:K10540 ko02010,ko02030,map02010,map02030 M00214 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.3 - - Peripla_BP_4,TAT_signal LANLAPFM_02490 622312.ROSEINA2194_01968 0.0 909.0 COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia 186801|Clostridia G import. Responsible for energy coupling to the transport system mglA - 3.6.3.17 ko:K10542 ko02010,map02010 M00214 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.3 - - ABC_tran LANLAPFM_02491 585394.RHOM_03890 3.55e-213 591.0 COG4211@1|root,COG4211@2|Bacteria,1UI1K@1239|Firmicutes,25EAQ@186801|Clostridia 186801|Clostridia G Belongs to the binding-protein-dependent transport system permease family mglC - - ko:K10541 ko02010,map02010 M00214 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.3 - - BPD_transp_2 LANLAPFM_02492 585394.RHOM_03895 2.7e-38 130.0 2FJ6E@1|root,34AWI@2|Bacteria,1W149@1239|Firmicutes,254EU@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02493 622312.ROSEINA2194_01971 1.22e-275 766.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia 186801|Clostridia T response regulator receiver - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg LANLAPFM_02494 622312.ROSEINA2194_01972 0.0 932.0 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia 186801|Clostridia T Histidine kinase - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,His_kinase,dCache_1 LANLAPFM_02495 585394.RHOM_03910 6.02e-83 261.0 COG1879@1|root,COG1879@2|Bacteria,1UD4W@1239|Firmicutes,24AYQ@186801|Clostridia 186801|Clostridia G COG1879 ABC-type sugar transport system periplasmic component - - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 LANLAPFM_02496 622312.ROSEINA2194_01974 5.51e-171 487.0 COG1879@1|root,COG1879@2|Bacteria,1TQW5@1239|Firmicutes,249PS@186801|Clostridia 186801|Clostridia G ABC-type sugar transport system periplasmic component - - - ko:K10540 ko02010,ko02030,map02010,map02030 M00214 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.3 - - Peripla_BP_4 LANLAPFM_02497 622312.ROSEINA2194_00443 2.54e-55 182.0 2DSNT@1|root,33GUR@2|Bacteria,1VNR5@1239|Firmicutes,24WQ3@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02498 622312.ROSEINA2194_02805 0.0 1500.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia 186801|Clostridia G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N LANLAPFM_02499 397290.C810_01190 1.26e-113 330.0 COG1309@1|root,COG1309@2|Bacteria,1V8TI@1239|Firmicutes,24F39@186801|Clostridia,27KFG@186928|unclassified Lachnospiraceae 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N,WHG LANLAPFM_02500 397288.C806_03259 1.57e-13 67.0 COG3976@1|root,COG3976@2|Bacteria,1VFG0@1239|Firmicutes,24RHT@186801|Clostridia,27MHD@186928|unclassified Lachnospiraceae 186801|Clostridia C FMN_bind - - - - - - - - - - - - FMN_bind LANLAPFM_02501 397288.C806_03259 1.03e-26 101.0 COG3976@1|root,COG3976@2|Bacteria,1VFG0@1239|Firmicutes,24RHT@186801|Clostridia,27MHD@186928|unclassified Lachnospiraceae 186801|Clostridia C FMN_bind - - - - - - - - - - - - FMN_bind LANLAPFM_02502 411465.PEPMIC_00759 1.62e-107 318.0 COG0716@1|root,COG1143@1|root,COG0716@2|Bacteria,COG1143@2|Bacteria,1TRYM@1239|Firmicutes,247NM@186801|Clostridia,22IFD@1570339|Peptoniphilaceae 186801|Clostridia C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4,Fer4_4,Flavodoxin_3,Flavodoxin_5 LANLAPFM_02503 1408306.JHXX01000001_gene2019 1.49e-153 447.0 COG2312@1|root,COG2312@2|Bacteria,1V2ED@1239|Firmicutes,24BHP@186801|Clostridia,4BXEN@830|Butyrivibrio 186801|Clostridia S Erythromycin esterase - - - ko:K06880 - - - - ko00000,ko01000,ko01504 - - - Erythro_esteras LANLAPFM_02504 445972.ANACOL_01323 4.31e-43 155.0 COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,248EH@186801|Clostridia,3WHT6@541000|Ruminococcaceae 186801|Clostridia P E1-E2 ATPase cadA - 3.6.3.3,3.6.3.5 ko:K01534 - - - - ko00000,ko01000 3.A.3.6 - - E1-E2_ATPase,HMA,Hydrolase LANLAPFM_02505 1235802.C823_05147 2.45e-180 513.0 COG0420@1|root,COG0420@2|Bacteria,1TQY6@1239|Firmicutes,248VE@186801|Clostridia,25VTM@186806|Eubacteriaceae 186801|Clostridia L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity sbcD - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos,SbcD_C LANLAPFM_02506 397291.C804_04903 1.97e-215 672.0 COG0419@1|root,COG1121@1|root,COG0419@2|Bacteria,COG1121@2|Bacteria,1TPCS@1239|Firmicutes,24A22@186801|Clostridia,27JHC@186928|unclassified Lachnospiraceae 186801|Clostridia L Putative exonuclease SbcCD, C subunit sbcC - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23,AAA_29,SbcCD_C LANLAPFM_02507 1392493.JIAB01000001_gene729 9.67e-308 841.0 COG1350@1|root,COG1350@2|Bacteria,1UI01@1239|Firmicutes,25E8Q@186801|Clostridia,27J2Z@186928|unclassified Lachnospiraceae 186801|Clostridia E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP LANLAPFM_02508 483218.BACPEC_02513 1.71e-79 239.0 COG1846@1|root,COG1846@2|Bacteria,1V8Z3@1239|Firmicutes,24I7U@186801|Clostridia,26BAN@186813|unclassified Clostridiales 186801|Clostridia K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR_2 LANLAPFM_02509 515620.EUBELI_20433 6.95e-298 828.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,25URG@186806|Eubacteriaceae 186801|Clostridia V ABC-type multidrug transport system, ATPase and permease - - - - - - - - - - - - ABC_membrane,ABC_tran LANLAPFM_02510 483218.BACPEC_02515 3.85e-262 734.0 COG1132@1|root,COG1132@2|Bacteria,1TPTK@1239|Firmicutes,249W7@186801|Clostridia 186801|Clostridia V Psort location CytoplasmicMembrane, score 10.00 - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_02511 585394.RHOM_08370 5.93e-166 466.0 COG1352@1|root,COG1352@2|Bacteria,1TPD8@1239|Firmicutes,24AQJ@186801|Clostridia 186801|Clostridia NT PFAM MCP methyltransferase, CheR-type cheR - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N LANLAPFM_02512 585394.RHOM_08375 1.19e-240 664.0 COG0539@1|root,COG0539@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia 186801|Clostridia J Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - - LYTB,S1 LANLAPFM_02513 585394.RHOM_08455 1.42e-150 432.0 COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia 186801|Clostridia O Belongs to the peptidase S8 family aprX - - ko:K17734 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S8 LANLAPFM_02514 585394.RHOM_08450 1.02e-276 767.0 COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,247UR@186801|Clostridia 186801|Clostridia I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol - - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N LANLAPFM_02515 585394.RHOM_08445 6.54e-182 518.0 COG1686@1|root,COG1686@2|Bacteria,1TQN0@1239|Firmicutes,249B3@186801|Clostridia 186801|Clostridia M Belongs to the peptidase S11 family dacF - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 LANLAPFM_02516 585394.RHOM_08440 5.03e-141 402.0 COG1354@1|root,COG1354@2|Bacteria,1TRW3@1239|Firmicutes,249VW@186801|Clostridia 186801|Clostridia D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA LANLAPFM_02517 585394.RHOM_08435 2.58e-109 317.0 COG1386@1|root,COG1386@2|Bacteria,1V6HI@1239|Firmicutes,24JW7@186801|Clostridia 186801|Clostridia D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB LANLAPFM_02518 585394.RHOM_08430 1.21e-176 504.0 COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia 186801|Clostridia M Belongs to the peptidase S11 family dacB2 - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 LANLAPFM_02519 585394.RHOM_08425 3.69e-290 798.0 COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,247WG@186801|Clostridia 186801|Clostridia I acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - - - - - - - - - - - Carboxyl_trans LANLAPFM_02520 585394.RHOM_08420 2.13e-95 286.0 2DMIV@1|root,32RW6@2|Bacteria,1VAMW@1239|Firmicutes,24DVC@186801|Clostridia 186801|Clostridia P decarboxylase gamma - - - - - - - - - - - - DUF3887,OAD_gamma LANLAPFM_02521 622312.ROSEINA2194_00498 4.57e-53 169.0 COG4770@1|root,COG4770@2|Bacteria,1VA1E@1239|Firmicutes,24MUJ@186801|Clostridia 186801|Clostridia I PFAM biotin lipoyl attachment domain-containing protein gcdC - - - - - - - - - - - Biotin_lipoyl LANLAPFM_02522 585394.RHOM_08410 1.32e-253 698.0 COG1883@1|root,COG1883@2|Bacteria,1TPEP@1239|Firmicutes,248ET@186801|Clostridia 186801|Clostridia C decarboxylase beta subunit gcdB - 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta LANLAPFM_02523 585394.RHOM_08405 0.0 892.0 COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia 186801|Clostridia C carboxylase oadA - 4.1.1.3 ko:K01571 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - HMGL-like,PYC_OADA LANLAPFM_02524 1235793.C809_02550 0.0 945.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,27IE8@186928|unclassified Lachnospiraceae 186801|Clostridia V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran LANLAPFM_02525 585394.RHOM_08395 8.75e-193 538.0 COG1737@1|root,COG1737@2|Bacteria,1TP7H@1239|Firmicutes,248ZD@186801|Clostridia 186801|Clostridia K transcriptional regulator RpiR family - - - - - - - - - - - - HTH_6,SIS LANLAPFM_02526 622312.ROSEINA2194_00502 5.16e-223 624.0 COG2081@1|root,COG2081@2|Bacteria,1TQ6E@1239|Firmicutes,247S5@186801|Clostridia 186801|Clostridia S Flavoprotein family - - - ko:K07007 - - - - ko00000 - - - HI0933_like LANLAPFM_02527 585394.RHOM_08385 3.02e-128 367.0 COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,24HEF@186801|Clostridia 186801|Clostridia F Belongs to the cytidylate kinase family. Type 1 subfamily cmk - 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin LANLAPFM_02528 622312.ROSEINA2194_03795 3.14e-284 782.0 COG0773@1|root,COG0773@2|Bacteria,1TQ5H@1239|Firmicutes,2484K@186801|Clostridia 186801|Clostridia M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M LANLAPFM_02529 622312.ROSEINA2194_03797 1.67e-141 413.0 COG3935@1|root,COG3935@2|Bacteria,1TPR5@1239|Firmicutes,248E7@186801|Clostridia 186801|Clostridia L DnaD domain protein dnaD - - - - - - - - - - - DnaB_2 LANLAPFM_02530 585394.RHOM_13180 3.91e-174 492.0 COG1484@1|root,COG1484@2|Bacteria,1TPKM@1239|Firmicutes,2483D@186801|Clostridia 186801|Clostridia L DNA replication protein dnaC - - ko:K02315 - - - - ko00000,ko03032 - - - IstB_IS21 LANLAPFM_02531 585394.RHOM_13185 6.04e-271 743.0 COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia 186801|Clostridia F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran,Pribosyltran_N LANLAPFM_02532 622312.ROSEINA2194_02903 2.9e-32 120.0 2E7V3@1|root,3329Y@2|Bacteria,1VHFN@1239|Firmicutes,24SN8@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02533 585394.RHOM_13195 2.9e-47 152.0 COG1925@1|root,COG1925@2|Bacteria,1UFZA@1239|Firmicutes,24MM8@186801|Clostridia 186801|Clostridia G Phosphocarrier protein (Hpr) - - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr LANLAPFM_02534 585394.RHOM_13200 0.0 1154.0 28IKE@1|root,2Z8M5@2|Bacteria,1TP2B@1239|Firmicutes,248C2@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 GcvP - - - - - - - - - - - Peptidase_C39_2 LANLAPFM_02535 585394.RHOM_13205 1.32e-72 222.0 2E5KN@1|root,330BS@2|Bacteria,1V5P2@1239|Firmicutes,24IND@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_02536 622312.ROSEINA2194_02907 0.0 1157.0 COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,24A10@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 31 family - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31 LANLAPFM_02537 585394.RHOM_13210 5.79e-37 125.0 2E45D@1|root,32Z1F@2|Bacteria,1VEXR@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - LANLAPFM_02538 1232443.BAIA02000064_gene1097 3.01e-128 377.0 COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,248IG@186801|Clostridia 186801|Clostridia P ABC-type nitrate sulfonate bicarbonate transport - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 LANLAPFM_02539 663278.Ethha_1750 4.44e-105 314.0 COG0600@1|root,COG0600@2|Bacteria,1TR6A@1239|Firmicutes,247VM@186801|Clostridia,3WHIC@541000|Ruminococcaceae 186801|Clostridia P ABC-type nitrate sulfonate bicarbonate transport system permease component ssuC_2 - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 LANLAPFM_02540 1280390.CBQR020000077_gene1694 2.79e-120 352.0 COG1116@1|root,COG1116@2|Bacteria,1TSW5@1239|Firmicutes,4HAFM@91061|Bacilli,26QI3@186822|Paenibacillaceae 91061|Bacilli P ABC-type nitrate sulfonate bicarbonate transport system, ATPase component - - - ko:K15555 ko00920,ko02010,map00920,map02010 M00436 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.17.2 - - ABC_tran LANLAPFM_02541 622312.ROSEINA2194_02909 2.92e-118 348.0 COG0598@1|root,COG0598@2|Bacteria,1TPSV@1239|Firmicutes,24DE3@186801|Clostridia 186801|Clostridia P transport protein CorA corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA LANLAPFM_02542 585394.RHOM_04695 5.96e-116 335.0 COG1102@1|root,COG1102@2|Bacteria,1TRCW@1239|Firmicutes,249Z9@186801|Clostridia 186801|Clostridia F Psort location Cytoplasmic, score cmk - - - - - - - - - - - Cytidylate_kin2 LANLAPFM_02543 1226325.HMPREF1548_05783 7.72e-89 291.0 COG0577@1|root,COG1196@1|root,COG0577@2|Bacteria,COG1196@2|Bacteria,1TPHU@1239|Firmicutes,248RV@186801|Clostridia,36E94@31979|Clostridiaceae 186801|Clostridia V Permease - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD LANLAPFM_02544 1235790.C805_03039 7.73e-69 244.0 COG5492@1|root,COG5492@2|Bacteria 2|Bacteria N domain, Protein - - - - - - - - - - - - Big_2,Flg_new,LRR_5,Peptidase_M26_N,SLH,fn3 LANLAPFM_02545 585394.RHOM_04790 4.58e-279 769.0 COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,247TA@186801|Clostridia 186801|Clostridia O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C LANLAPFM_02546 483218.BACPEC_01795 1.09e-87 286.0 COG1669@1|root,COG4227@1|root,COG1669@2|Bacteria,COG4227@2|Bacteria,1TQN4@1239|Firmicutes,2482H@186801|Clostridia,268CY@186813|unclassified Clostridiales 186801|Clostridia L Domain of unknown function (DUF4316) - - - - - - - - - - - - DUF3849,DUF4316,Peptidase_M78,YodL,zf-CHC2 LANLAPFM_02547 483218.BACPEC_01796 3.3e-39 130.0 2DP0F@1|root,3321I@2|Bacteria,1VEWX@1239|Firmicutes,24TDI@186801|Clostridia 186801|Clostridia S Putative tranposon-transfer assisting protein - - - - - - - - - - - - TTRAP LANLAPFM_02548 742765.HMPREF9457_01691 5.76e-52 173.0 COG4804@1|root,COG4804@2|Bacteria,1TP7Q@1239|Firmicutes,24A19@186801|Clostridia,27WRE@189330|Dorea 186801|Clostridia S Protein of unknown function (DUF1016) - - - - - - - - - - - - DUF1016 LANLAPFM_02549 97139.C824_04617 1.33e-235 659.0 COG3843@1|root,COG3843@2|Bacteria,1TPRX@1239|Firmicutes,2481D@186801|Clostridia,36E9W@31979|Clostridiaceae 186801|Clostridia U Relaxase/Mobilisation nuclease domain - - - - - - - - - - - - Relaxase LANLAPFM_02550 1235793.C809_00188 1.91e-54 172.0 296J0@1|root,30WDX@2|Bacteria,1UICE@1239|Firmicutes,25EHH@186801|Clostridia,27N3K@186928|unclassified Lachnospiraceae 186801|Clostridia S Bacterial mobilisation protein (MobC) - - - - - - - - - - - - MobC LANLAPFM_02551 585394.RHOM_11905 2.59e-206 589.0 COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia 186801|Clostridia O PDZ DHR GLGF domain protein - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 LANLAPFM_02552 1408321.JNJD01000008_gene2040 2.88e-184 528.0 COG0603@1|root,COG0603@2|Bacteria,1V0EU@1239|Firmicutes,24BK5@186801|Clostridia,27KYX@186928|unclassified Lachnospiraceae 186801|Clostridia F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) - - - - - - - - - - - - - LANLAPFM_02553 1410628.JNKS01000072_gene1060 9.09e-159 459.0 COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,248GS@186801|Clostridia,27IMU@186928|unclassified Lachnospiraceae 186801|Clostridia M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iHN637.CLJU_RS20420 Mur_ligase_C,Mur_ligase_M LANLAPFM_02554 585394.RHOM_11815 7.72e-281 772.0 COG2256@1|root,COG2256@2|Bacteria,1TPVV@1239|Firmicutes,247X2@186801|Clostridia 186801|Clostridia L ATPase related to the helicase subunit of the Holliday junction resolvase rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N LANLAPFM_02555 585394.RHOM_11810 2.93e-299 817.0 COG1167@1|root,COG1167@2|Bacteria,1TPMY@1239|Firmicutes,24986@186801|Clostridia 186801|Clostridia EK Psort location Cytoplasmic, score - - - - - - - - - - - - Aminotran_MocR LANLAPFM_02556 585394.RHOM_11800 3.85e-89 267.0 2BYUV@1|root,307Y4@2|Bacteria,1V64G@1239|Firmicutes,24K9A@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02557 622312.ROSEINA2194_03404 6.36e-169 476.0 COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,24898@186801|Clostridia 186801|Clostridia I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N LANLAPFM_02558 622312.ROSEINA2194_03403 7.82e-129 369.0 COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,24C0U@186801|Clostridia 186801|Clostridia K domain protein GntR - - - - - - - - - - - FCD,GntR LANLAPFM_02559 585394.RHOM_11785 3.68e-293 807.0 COG0697@1|root,COG0697@2|Bacteria,1TP7K@1239|Firmicutes,248Q8@186801|Clostridia 186801|Clostridia EG GerA spore germination protein gerA - - ko:K06310 - - - - ko00000 - - - GerA LANLAPFM_02560 585394.RHOM_11780 3.83e-213 620.0 COG0814@1|root,COG0814@2|Bacteria,1V9NE@1239|Firmicutes,25DGZ@186801|Clostridia 186801|Clostridia E Spore germination protein - - - - - - - - - - - - Spore_permease LANLAPFM_02561 622312.ROSEINA2194_03400 5.77e-71 222.0 2AUKD@1|root,31K93@2|Bacteria,1V6PK@1239|Firmicutes,24J91@186801|Clostridia 186801|Clostridia S stage ii sporulation protein r spoIIR - - ko:K06387 - - - - ko00000 - - - Spore_II_R LANLAPFM_02562 397290.C810_01003 1.51e-71 218.0 COG4506@1|root,COG4506@2|Bacteria,1V8CS@1239|Firmicutes,24JQR@186801|Clostridia,27N6U@186928|unclassified Lachnospiraceae 186801|Clostridia S Domain of unknown function (DUF1934) ywiB - - - - - - - - - - - DUF1934 LANLAPFM_02563 585394.RHOM_11895 5.67e-296 810.0 COG0366@1|root,COG0366@2|Bacteria,1TQFJ@1239|Firmicutes,249Y3@186801|Clostridia 186801|Clostridia G Alpha amylase, catalytic domain protein - - 3.2.1.133,3.2.1.135,3.2.1.54 ko:K01208 ko00500,ko01100,map00500,map01100 - R02112,R03122,R11262 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Alpha-amylase_N LANLAPFM_02564 585394.RHOM_11890 1.88e-144 412.0 COG0345@1|root,COG0345@2|Bacteria,1TP1E@1239|Firmicutes,247SR@186801|Clostridia 186801|Clostridia E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer LANLAPFM_02565 622312.ROSEINA2194_00963 2.66e-37 130.0 COG3190@1|root,COG3190@2|Bacteria,1VCEI@1239|Firmicutes,25FCZ@186801|Clostridia 186801|Clostridia N Flagellar biosynthesis protein, FliO - - - ko:K02418 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliO LANLAPFM_02566 585394.RHOM_07015 4.64e-76 227.0 COG2197@1|root,COG2197@2|Bacteria,1UIGG@1239|Firmicutes,25EMX@186801|Clostridia 186801|Clostridia T response regulator receiver - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg LANLAPFM_02567 585394.RHOM_07010 6.25e-191 540.0 COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,1TPT8@1239|Firmicutes,24821@186801|Clostridia 186801|Clostridia N Flagellar motor switch protein flin fliN - - ko:K02417 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - CheC,FliMN_C LANLAPFM_02568 585394.RHOM_07005 3.2e-203 566.0 COG1868@1|root,COG1868@2|Bacteria,1TPTM@1239|Firmicutes,24AGV@186801|Clostridia 186801|Clostridia N flagellar motor switch protein FliM fliM - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C LANLAPFM_02569 585394.RHOM_07000 3.43e-66 207.0 2AHM3@1|root,317YZ@2|Bacteria,1V80Z@1239|Firmicutes,24M4F@186801|Clostridia 186801|Clostridia S Controls the rotational direction of flagella during chemotaxis - - - ko:K02415 - - - - ko00000,ko02035 - - - FliL LANLAPFM_02570 585394.RHOM_06995 5e-112 331.0 COG1360@1|root,COG1360@2|Bacteria,1V8KE@1239|Firmicutes,24GQQ@186801|Clostridia 186801|Clostridia N PFAM OmpA MotB domain protein - - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA LANLAPFM_02571 585394.RHOM_06990 4.53e-138 395.0 COG1291@1|root,COG1291@2|Bacteria,1TRH1@1239|Firmicutes,24AEJ@186801|Clostridia 186801|Clostridia N PFAM MotA TolQ ExbB proton channel motA - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB LANLAPFM_02572 1235790.C805_02008 5.92e-24 92.0 COG1582@1|root,COG1582@2|Bacteria,1VKHB@1239|Firmicutes,24RWI@186801|Clostridia,25XPE@186806|Eubacteriaceae 186801|Clostridia N Flagellar protein (FlbD) flbD - - ko:K02385 - - - - ko00000,ko02035 - - - FlbD LANLAPFM_02573 585394.RHOM_06985 5.51e-228 647.0 COG1749@1|root,COG1749@2|Bacteria,1UHS7@1239|Firmicutes,247ZT@186801|Clostridia 186801|Clostridia N basal body rod protein flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C LANLAPFM_02574 585394.RHOM_06980 8.74e-55 174.0 2E35U@1|root,32Y5R@2|Bacteria,1VEH9@1239|Firmicutes,24R2S@186801|Clostridia 186801|Clostridia N TIGRFAM flagellar operon protein flg - - - - - - - - - - - Flagellar_put LANLAPFM_02575 585394.RHOM_06975 4.43e-78 243.0 COG1843@1|root,COG1843@2|Bacteria,1VF85@1239|Firmicutes,24QKD@186801|Clostridia 186801|Clostridia N Required for flagellar hook formation. May act as a scaffolding protein flgD - - ko:K02389 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FLgD_tudor,FlgD LANLAPFM_02576 585394.RHOM_06970 1.18e-88 287.0 COG3144@1|root,COG3144@2|Bacteria,1V4YB@1239|Firmicutes,24JMD@186801|Clostridia 186801|Clostridia N Flagellar hook-length control protein fliK - - ko:K02414 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_hook LANLAPFM_02577 585394.RHOM_06965 1.14e-106 318.0 28H98@1|root,2Z7M1@2|Bacteria,1TRE9@1239|Firmicutes,24F21@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - MgtE_N LANLAPFM_02578 585394.RHOM_06960 1.36e-59 188.0 COG2882@1|root,COG2882@2|Bacteria,1VK96@1239|Firmicutes,24RWK@186801|Clostridia 186801|Clostridia NOU flagellar export protein FliJ fliJ - - ko:K02413 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliJ LANLAPFM_02579 622312.ROSEINA2194_00945 4.32e-270 744.0 COG1157@1|root,COG1157@2|Bacteria,1TP0R@1239|Firmicutes,25E6B@186801|Clostridia 186801|Clostridia NU Flagellar protein export ATPase FliI fliI - 3.6.3.14 ko:K02412,ko:K03224 ko02040,ko03070,map02040,map03070 M00332,M00542,M00660 - - ko00000,ko00001,ko00002,ko01000,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 - - ATP-synt_ab,ATP-synt_ab_N LANLAPFM_02580 585394.RHOM_06950 4.89e-52 177.0 COG1317@1|root,COG1317@2|Bacteria,1V7UQ@1239|Firmicutes 1239|Firmicutes NU Flagellar assembly protein FliH - - - ko:K02411 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliH LANLAPFM_02581 585394.RHOM_06945 1.56e-213 593.0 COG1536@1|root,COG1536@2|Bacteria,1TP01@1239|Firmicutes,2480B@186801|Clostridia 186801|Clostridia N Flagellar motor switch protein flig fliG - - ko:K02410 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliG_C,FliG_M,FliG_N LANLAPFM_02582 622312.ROSEINA2194_00942 2.04e-226 642.0 COG1766@1|root,COG1766@2|Bacteria,1TRK0@1239|Firmicutes,2498Q@186801|Clostridia 186801|Clostridia N The M ring may be actively involved in energy transduction fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C LANLAPFM_02583 622312.ROSEINA2194_00941 9.85e-41 137.0 COG1677@1|root,COG1677@2|Bacteria 2|Bacteria N Flagellar hook-basal body complex protein FliE fliE - - ko:K02408 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliE LANLAPFM_02584 585394.RHOM_06925 1.29e-79 238.0 COG1558@1|root,COG1558@2|Bacteria,1V6NB@1239|Firmicutes,24JJW@186801|Clostridia 186801|Clostridia N Belongs to the flagella basal body rod proteins family flgC - - ko:K02388 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C LANLAPFM_02585 622312.ROSEINA2194_00939 3.78e-58 183.0 COG1815@1|root,COG1815@2|Bacteria,1VEUZ@1239|Firmicutes,24RBE@186801|Clostridia 186801|Clostridia N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body flgB - - ko:K02387 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod LANLAPFM_02586 622312.ROSEINA2194_03055 6.63e-151 432.0 COG1464@1|root,COG1464@2|Bacteria,1TQAS@1239|Firmicutes,247WV@186801|Clostridia 186801|Clostridia P Belongs to the nlpA lipoprotein family metQ - - ko:K02073 ko02010,map02010 M00238 - - ko00000,ko00001,ko00002,ko02000 3.A.1.24 - - Lipoprotein_9 LANLAPFM_02587 585394.RHOM_12805 5.42e-128 367.0 COG2011@1|root,COG2011@2|Bacteria,1TRSY@1239|Firmicutes,24AZ9@186801|Clostridia 186801|Clostridia P ABC-type metal ion transport system permease component metI - - ko:K02072 ko02010,map02010 M00238 - - ko00000,ko00001,ko00002,ko02000 3.A.1.24 - - BPD_transp_1 LANLAPFM_02588 622312.ROSEINA2194_03057 3.09e-178 504.0 COG1135@1|root,COG1135@2|Bacteria,1TPPN@1239|Firmicutes,248PZ@186801|Clostridia 186801|Clostridia P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system metN - - ko:K02071 ko02010,map02010 M00238 - - ko00000,ko00001,ko00002,ko02000 3.A.1.24 - - ABC_tran,NIL LANLAPFM_02590 622312.ROSEINA2194_03059 9.87e-190 530.0 COG0583@1|root,COG0583@2|Bacteria,1TP3E@1239|Firmicutes,248HI@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_1,LysR_substrate LANLAPFM_02591 585394.RHOM_12825 2.39e-149 427.0 COG1284@1|root,COG1284@2|Bacteria,1TRAU@1239|Firmicutes,249DE@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF2179,YitT_membrane LANLAPFM_02592 622312.ROSEINA2194_00531 9.66e-68 209.0 2E06E@1|root,32VUE@2|Bacteria,1VCMY@1239|Firmicutes,24NKQ@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02595 1504823.CCMM01000008_gene907 1.81e-153 439.0 COG0524@1|root,COG0524@2|Bacteria 2|Bacteria G Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway yeiI - 2.7.1.15,2.7.1.45,2.7.1.83 ko:K00852,ko:K00874,ko:K16328 ko00030,ko00240,ko01100,ko01120,ko01200,map00030,map00240,map01100,map01120,map01200 M00061,M00308,M00631 R01051,R01541,R02750,R03315 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HTH_24,PfkB LANLAPFM_02596 411489.CLOL250_01422 6.08e-05 43.5 2EMZ1@1|root,33FM6@2|Bacteria,1VMDZ@1239|Firmicutes,24X8Z@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02597 411489.CLOL250_01423 3.4e-235 652.0 COG0786@1|root,COG0786@2|Bacteria,1TQA4@1239|Firmicutes,247WX@186801|Clostridia,36EF4@31979|Clostridiaceae 186801|Clostridia P Catalyzes the sodium-dependent transport of glutamate gltS - - ko:K03312 - - - - ko00000,ko02000 2.A.27 - - Glt_symporter,NMT1_3 LANLAPFM_02598 411489.CLOL250_01424 2.48e-122 360.0 COG2358@1|root,COG2358@2|Bacteria,1TPXW@1239|Firmicutes,2489U@186801|Clostridia,36I0C@31979|Clostridiaceae 186801|Clostridia S TRAP transporter solute receptor, TAXI family bcsP - - ko:K07080 - - - - ko00000 - - - NMT1_3 LANLAPFM_02599 585394.RHOM_12905 2.52e-316 866.0 COG4690@1|root,COG4690@2|Bacteria,1TQ0F@1239|Firmicutes,248K3@186801|Clostridia 186801|Clostridia E Dipeptidase pepD - - ko:K08659 - - - - ko00000,ko01000,ko01002 - - - Peptidase_C69 LANLAPFM_02600 140626.JHWB01000022_gene2128 2.64e-81 248.0 COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,24J27@186801|Clostridia 186801|Clostridia G Phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 LANLAPFM_02601 622312.ROSEINA2194_00248 5.61e-262 724.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia 186801|Clostridia V Mate efflux family protein - - - - - - - - - - - - MatE LANLAPFM_02602 622312.ROSEINA2194_00247 6.79e-229 638.0 COG4286@1|root,COG4286@2|Bacteria,1V2PW@1239|Firmicutes,248SR@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - UPF0160 LANLAPFM_02603 642492.Clole_1528 4.42e-84 280.0 COG0840@1|root,COG3290@1|root,COG0840@2|Bacteria,COG3290@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia 186801|Clostridia NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - Cache_3-Cache_2,MCPsignal LANLAPFM_02604 1211035.CD30_15240 9.93e-10 60.5 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4HF4R@91061|Bacilli,3J03Q@400634|Lysinibacillus 91061|Bacilli L Group II intron, maturase-specific domain - - - - - - - - - - - - GIIM,RVT_1 LANLAPFM_02605 585501.HMPREF6123_1762 1.28e-13 71.2 COG0433@1|root,COG0433@2|Bacteria,1TQPR@1239|Firmicutes,249UU@186801|Clostridia,2PR5K@265975|Oribacterium 186801|Clostridia S Domain of unknown function DUF87 - - - - - - - - - - - - DUF87 LANLAPFM_02606 515620.EUBELI_20648 4.69e-15 76.6 COG0840@1|root,COG5000@1|root,COG0840@2|Bacteria,COG5000@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,25VY7@186806|Eubacteriaceae 186801|Clostridia NT Methyl-accepting chemotaxis protein (MCP) signaling domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal LANLAPFM_02607 397288.C806_02914 1.47e-27 103.0 COG0242@1|root,COG0242@2|Bacteria,1V73T@1239|Firmicutes,24FT0@186801|Clostridia,27MB2@186928|unclassified Lachnospiraceae 186801|Clostridia J Removes the formyl group from the N-terminal Met of newly synthesized proteins def2 - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase LANLAPFM_02608 478749.BRYFOR_05625 2.97e-288 814.0 COG1609@1|root,COG1653@1|root,COG1609@2|Bacteria,COG1653@2|Bacteria,1V31R@1239|Firmicutes,249JU@186801|Clostridia 186801|Clostridia K solute-binding protein - - - - - - - - - - - - LacI,Peripla_BP_1,Peripla_BP_4,SBP_bac_1,SBP_bac_8 LANLAPFM_02609 622312.ROSEINA2194_00296 1.37e-157 447.0 COG1307@1|root,COG1307@2|Bacteria,1TQDI@1239|Firmicutes,24ADT@186801|Clostridia 186801|Clostridia S EDD domain protein, DegV family - - - - - - - - - - - - DegV LANLAPFM_02610 1123313.ATUT01000032_gene1895 6.07e-34 119.0 COG1917@1|root,COG1917@2|Bacteria,1TRVH@1239|Firmicutes,3VQSY@526524|Erysipelotrichia 526524|Erysipelotrichia S Cupin domain protein - - - - - - - - - - - - CMD,Cupin_2 LANLAPFM_02611 411489.CLOL250_02558 5.96e-09 52.4 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2,Cupin_7 LANLAPFM_02612 1235790.C805_03449 2.66e-59 184.0 COG0393@1|root,COG0393@2|Bacteria,1VADM@1239|Firmicutes,24J8R@186801|Clostridia,25WII@186806|Eubacteriaceae 186801|Clostridia S Belongs to the UPF0145 family - - - - - - - - - - - - YbjQ_1 LANLAPFM_02613 1232453.BAIF02000049_gene828 5e-15 70.1 2ENA7@1|root,33FXX@2|Bacteria,1VMBP@1239|Firmicutes,24USY@186801|Clostridia,26CD2@186813|unclassified Clostridiales 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02614 622312.ROSEINA2194_01496 1.96e-112 342.0 COG0727@1|root,COG0727@2|Bacteria,1UZ5G@1239|Firmicutes,25GD9@186801|Clostridia 186801|Clostridia S PFAM Uncharacterised protein family (UPF0153) - - - ko:K18475 - - - - ko00000,ko01000,ko02035 - - - - LANLAPFM_02615 585394.RHOM_06120 0.0 921.0 COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia 186801|Clostridia S Abc transporter yfmM - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_Xtn LANLAPFM_02616 585394.RHOM_06110 2.38e-254 706.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia 186801|Clostridia V Mate efflux family protein - - - - - - - - - - - - MatE LANLAPFM_02617 585394.RHOM_06105 4.28e-155 444.0 COG0760@1|root,COG0760@2|Bacteria,1V8DP@1239|Firmicutes,24F9F@186801|Clostridia 186801|Clostridia O Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation - - 5.2.1.8 ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3 LANLAPFM_02618 585394.RHOM_06100 0.0 884.0 COG2509@1|root,COG2509@2|Bacteria,1TP9I@1239|Firmicutes,247QM@186801|Clostridia 186801|Clostridia S 'oxidoreductase - - - ko:K07137 - - - - ko00000 - - - FAD_binding_2,HI0933_like,Pyr_redox_2,Thi4 LANLAPFM_02619 397290.C810_03072 2.71e-37 127.0 2E51P@1|root,32ZV2@2|Bacteria,1VFYG@1239|Firmicutes,24QWN@186801|Clostridia,27P0I@186928|unclassified Lachnospiraceae 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_02620 622312.ROSEINA2194_01555 1.6e-103 304.0 COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,24JRN@186801|Clostridia 186801|Clostridia D Maf-like protein maf - - ko:K06287 - - - - ko00000 - - - Maf LANLAPFM_02621 585394.RHOM_06085 0.0 1500.0 COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,248ZF@186801|Clostridia 186801|Clostridia L ATP-dependent helicase nuclease subunit A addA - 3.6.4.12 ko:K16898 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C LANLAPFM_02622 622312.ROSEINA2194_01559 0.0 1481.0 COG3857@1|root,COG3857@2|Bacteria,1TQJW@1239|Firmicutes,2487T@186801|Clostridia 186801|Clostridia L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation addB - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - Exonuc_V_gamma,PDDEXK_1,UvrD_C LANLAPFM_02623 585394.RHOM_06135 0.0 1054.0 COG0326@1|root,COG0326@2|Bacteria,1TQEU@1239|Firmicutes,247ND@186801|Clostridia 186801|Clostridia O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 LANLAPFM_02624 1235792.C808_00459 1.3e-200 565.0 COG1979@1|root,COG1979@2|Bacteria,1TPS3@1239|Firmicutes,248DW@186801|Clostridia,27IBJ@186928|unclassified Lachnospiraceae 186801|Clostridia C Iron-containing alcohol dehydrogenase - - - ko:K19955 - - - - ko00000,ko01000 - - - Fe-ADH LANLAPFM_02625 585394.RHOM_04685 1.08e-212 598.0 COG0486@1|root,COG0486@2|Bacteria,1TQA8@1239|Firmicutes,247M4@186801|Clostridia 186801|Clostridia S Hydrogenase maturation GTPase HydF hydF - - - - - - - - - - - MMR_HSR1 LANLAPFM_02626 585394.RHOM_04680 0.0 892.0 COG0502@1|root,COG0502@2|Bacteria,1TPEX@1239|Firmicutes,248PF@186801|Clostridia 186801|Clostridia C biosynthesis protein ThiH hydG - 4.1.99.19 ko:K03150 ko00730,ko01100,map00730,map01100 - R10246 RC01434,RC03095 ko00000,ko00001,ko01000 - - - BATS,Radical_SAM LANLAPFM_02627 585394.RHOM_04675 3.95e-193 543.0 COG0502@1|root,COG0502@2|Bacteria,1TPYQ@1239|Firmicutes,248H8@186801|Clostridia 186801|Clostridia C Iron-only hydrogenase maturation rSAM protein HydE hydE - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM LANLAPFM_02628 585394.RHOM_04670 5.81e-42 138.0 COG0864@1|root,COG0864@2|Bacteria,1VF9M@1239|Firmicutes,24QVJ@186801|Clostridia 186801|Clostridia K Iron-only hydrogenase system regulator - - - - - - - - - - - - - LANLAPFM_02629 515622.bpr_I1351 3.56e-52 167.0 COG0375@1|root,COG0375@2|Bacteria,1VABW@1239|Firmicutes,24NES@186801|Clostridia,4BZG4@830|Butyrivibrio 186801|Clostridia S Hydrogenase/urease nickel incorporation, metallochaperone, hypA - - - ko:K04651 - - - - ko00000,ko03110 - - - HypA LANLAPFM_02630 665956.HMPREF1032_02341 0.0 1460.0 COG0493@1|root,COG1143@1|root,COG4231@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,COG4231@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,3WHYH@541000|Ruminococcaceae 186801|Clostridia C Pyridine nucleotide-disulphide oxidoreductase - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_9,Pyr_redox_2,Pyr_redox_3 LANLAPFM_02631 515622.bpr_I1350 1.13e-127 366.0 COG0378@1|root,COG0378@2|Bacteria,1TS00@1239|Firmicutes,248T1@186801|Clostridia,4BXWJ@830|Butyrivibrio 186801|Clostridia KO CobW/HypB/UreG, nucleotide-binding domain hypB - - ko:K04652 - - - - ko00000,ko03110 - - - cobW LANLAPFM_02633 641112.ACOK01000114_gene2305 5.36e-80 240.0 COG5113@1|root,COG3236@2|Bacteria,1UY8T@1239|Firmicutes,2486K@186801|Clostridia,3WGS9@541000|Ruminococcaceae 186801|Clostridia O Domain of unknown function (DUF1768) - - - ko:K09935 - - - - ko00000 - - - DUF1768 LANLAPFM_02634 518637.EUBIFOR_02026 3.97e-77 231.0 29AZ1@1|root,2ZXY1@2|Bacteria,1V4KY@1239|Firmicutes,3VTCC@526524|Erysipelotrichia 526524|Erysipelotrichia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - LANLAPFM_02635 585501.HMPREF6123_1167 6.94e-118 341.0 28KQ0@1|root,2ZA7Z@2|Bacteria,1V4X7@1239|Firmicutes,24E87@186801|Clostridia,2PTNA@265975|Oribacterium 186801|Clostridia S Protein of unknown function (DUF3990) - - - - - - - - - - - - DUF3990 LANLAPFM_02637 411489.CLOL250_02048 1.4e-18 100.0 COG3209@1|root,COG3210@1|root,COG3209@2|Bacteria,COG3210@2|Bacteria,1W1CQ@1239|Firmicutes,24Q72@186801|Clostridia,36NF6@31979|Clostridiaceae 186801|Clostridia M Conserved repeat domain - - - - - - - - - - - - - LANLAPFM_02638 1195236.CTER_3937 5.15e-116 349.0 COG0438@1|root,COG0438@2|Bacteria,1TPY6@1239|Firmicutes,24834@186801|Clostridia,3WHNS@541000|Ruminococcaceae 186801|Clostridia M Glycosyl transferase 4-like epsD - - ko:K19422 - - - - ko00000,ko01000 - GT4 - Glyco_trans_4_2,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 LANLAPFM_02640 1235798.C817_00116 8.8e-99 299.0 COG0451@1|root,COG0451@2|Bacteria 2|Bacteria GM ADP-glyceromanno-heptose 6-epimerase activity wbpV - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase LANLAPFM_02641 1121289.JHVL01000007_gene2812 1.98e-108 317.0 COG2148@1|root,COG2148@2|Bacteria,1TQX9@1239|Firmicutes,24874@186801|Clostridia,36VHP@31979|Clostridiaceae 186801|Clostridia M Bacterial sugar transferase - - - ko:K13012 - - - - ko00000,ko01005 - - - Bac_transf,Epimerase LANLAPFM_02642 742735.HMPREF9467_03385 3.39e-72 240.0 COG3950@1|root,COG3950@2|Bacteria,1V5R6@1239|Firmicutes,24DVP@186801|Clostridia,222SD@1506553|Lachnoclostridium 186801|Clostridia S AAA ATPase domain - - - - - - - - - - - - AAA_15,AAA_21 LANLAPFM_02643 622312.ROSEINA2194_02593 6.14e-308 855.0 COG1086@1|root,COG1086@2|Bacteria,1TR3W@1239|Firmicutes,247PW@186801|Clostridia 186801|Clostridia GM Polysaccharide biosynthesis protein capD - - - - - - - - - - - CoA_binding_3,Polysacc_synt_2 LANLAPFM_02644 1280680.AUJU01000007_gene2291 3.66e-20 105.0 COG3210@1|root,COG4124@1|root,COG3210@2|Bacteria,COG4124@2|Bacteria,1VHC1@1239|Firmicutes,25KX4@186801|Clostridia,4C0YQ@830|Butyrivibrio 186801|Clostridia GU Ricin-type beta-trefoil - - - - - - - - - - - - Flg_new,LRR_5,RicinB_lectin_2 LANLAPFM_02645 1042156.CXIVA_03070 2.47e-90 291.0 COG2059@1|root,COG2059@2|Bacteria,1UFAG@1239|Firmicutes 1239|Firmicutes P Chromate transporter - - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp LANLAPFM_02646 1235799.C818_00825 3.22e-36 143.0 COG1874@1|root,COG1874@2|Bacteria,1V23M@1239|Firmicutes,24GDA@186801|Clostridia 186801|Clostridia G Beta-galactosidase - - - - - - - - - - - - - LANLAPFM_02647 1256908.HMPREF0373_02124 0.0 916.0 COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1TQXK@1239|Firmicutes,25EK3@186801|Clostridia,25ZJY@186806|Eubacteriaceae 186801|Clostridia F Catalyzes the synthesis of activated sulfate cysC - 2.7.1.25,2.7.7.4 ko:K00955 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,GTP_EFTU,GTP_EFTU_D3 LANLAPFM_02648 411459.RUMOBE_04067 4.39e-194 540.0 COG0175@1|root,COG0175@2|Bacteria,1U1VN@1239|Firmicutes,248Y9@186801|Clostridia,3Y143@572511|Blautia 186801|Clostridia H Phosphoadenosine phosphosulfate reductase family cysD - 1.8.4.10,1.8.4.8,2.7.7.4 ko:K00390,ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R02021,R04929 RC00007,RC02809,RC02862,RC02889 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct LANLAPFM_02649 1235799.C818_03733 1.45e-109 337.0 COG5002@1|root,COG5002@2|Bacteria,1TPSK@1239|Firmicutes,24A2N@186801|Clostridia,27JN2@186928|unclassified Lachnospiraceae 186801|Clostridia T His Kinase A (phospho-acceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA LANLAPFM_02650 1042156.CXIVA_19110 2.43e-34 123.0 COG2388@1|root,COG4545@1|root,COG2388@2|Bacteria,COG4545@2|Bacteria,1UJ9G@1239|Firmicutes,24R2R@186801|Clostridia,36VVY@31979|Clostridiaceae 186801|Clostridia O GCN5-related N-acetyl-transferase - - - ko:K06975 - - - - ko00000 - - - Acetyltransf_CG,Glutaredoxin LANLAPFM_02651 658088.HMPREF0987_02092 0.0 1103.0 COG3250@1|root,COG3250@2|Bacteria,1TPK7@1239|Firmicutes,247VE@186801|Clostridia,27J10@186928|unclassified Lachnospiraceae 186801|Clostridia G Domain of unknown function (DUF4982) - - - - - - - - - - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N LANLAPFM_02652 658088.HMPREF0987_02093 1.68e-248 691.0 COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,24ABB@186801|Clostridia,27IIX@186928|unclassified Lachnospiraceae 186801|Clostridia G MFS/sugar transport protein - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 LANLAPFM_02653 658088.HMPREF0987_02094 1.74e-145 422.0 COG2169@1|root,COG2169@2|Bacteria,1VC5Z@1239|Firmicutes,24I65@186801|Clostridia,27N4N@186928|unclassified Lachnospiraceae 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_binding,HTH_18 LANLAPFM_02654 1280679.ATVX01000017_gene218 2.05e-36 125.0 COG1254@1|root,COG1254@2|Bacteria,1VEM9@1239|Firmicutes,24QXB@186801|Clostridia,4BZS5@830|Butyrivibrio 186801|Clostridia C Acylphosphatase acyP - 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase LANLAPFM_02655 585394.RHOM_14945 8.32e-29 103.0 2E7J1@1|root,3321A@2|Bacteria,1VFYW@1239|Firmicutes,24RBB@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02656 140626.JHWB01000022_gene2109 3.94e-31 110.0 2ERQJ@1|root,33J9V@2|Bacteria,1VQ8Z@1239|Firmicutes,24VCG@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02657 622312.ROSEINA2194_00271 3e-122 353.0 COG2176@1|root,COG2176@2|Bacteria,1TRS5@1239|Firmicutes,24ER5@186801|Clostridia 186801|Clostridia L EXOIII - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - BRCT,RNase_T,zf-C4_Topoisom LANLAPFM_02658 411463.EUBVEN_02075 2.76e-94 278.0 COG0406@1|root,COG0406@2|Bacteria,1V25J@1239|Firmicutes,24FZT@186801|Clostridia,25W5C@186806|Eubacteriaceae 186801|Clostridia G Cytoplasmic, score 8.87 - - - - - - - - - - - - His_Phos_1 LANLAPFM_02659 1256908.HMPREF0373_01583 3.15e-51 162.0 2DZI1@1|root,32VB8@2|Bacteria,1VAA5@1239|Firmicutes,24MWS@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - FYDLN_acid LANLAPFM_02660 97138.C820_01583 3.81e-53 184.0 COG5464@1|root,COG5464@2|Bacteria,1UI9X@1239|Firmicutes,25EEV@186801|Clostridia,36UNA@31979|Clostridiaceae 186801|Clostridia S Putative transposase, YhgA-like - - - - - - - - - - - - - LANLAPFM_02661 515620.EUBELI_00422 4.12e-129 393.0 COG1344@1|root,COG1344@2|Bacteria,1TP1K@1239|Firmicutes,247JQ@186801|Clostridia,25VSN@186806|Eubacteriaceae 186801|Clostridia N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella - - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N LANLAPFM_02662 622312.ROSEINA2194_00548 4.4e-33 117.0 2ENS3@1|root,33GD8@2|Bacteria,1VQH1@1239|Firmicutes,24VFX@186801|Clostridia 186801|Clostridia S Global regulator protein family - - - - - - - - - - - - CsrA LANLAPFM_02663 397288.C806_01154 3.64e-90 269.0 COG0582@1|root,COG0582@2|Bacteria,1V2RX@1239|Firmicutes,24DD0@186801|Clostridia,27QUG@186928|unclassified Lachnospiraceae 186801|Clostridia L Phage integrase family - - - - - - - - - - - - Phage_integrase LANLAPFM_02664 622312.ROSEINA2194_04436 2.31e-161 454.0 28P0Q@1|root,2ZBX8@2|Bacteria,1V22P@1239|Firmicutes,248XV@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_02665 585394.RHOM_14335 1.71e-47 155.0 COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,24MXH@186801|Clostridia 186801|Clostridia S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd LANLAPFM_02666 622312.ROSEINA2194_00449 1.59e-316 869.0 COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia 186801|Clostridia L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 LANLAPFM_02667 585394.RHOM_14345 1.31e-245 676.0 COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,249AM@186801|Clostridia 186801|Clostridia H Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK LANLAPFM_02668 622312.ROSEINA2194_04141 5.47e-175 490.0 COG3711@1|root,COG3711@2|Bacteria,1TT5A@1239|Firmicutes,24931@186801|Clostridia 186801|Clostridia K transcriptional antiterminator licT - - ko:K03488 - - - - ko00000,ko03000 - - - CAT_RBD,PRD LANLAPFM_02669 622312.ROSEINA2194_04140 2.23e-89 264.0 COG2190@1|root,COG2190@2|Bacteria,1VAEB@1239|Firmicutes 1239|Firmicutes G PTS system, glucose subfamily, IIA ptbA - - ko:K02755,ko:K02756,ko:K02757,ko:K02777 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00270,M00271,M00272,M00303,M00806 R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6 - - PTS_EIIA_1,PTS_EIIB,PTS_EIIC LANLAPFM_02670 622312.ROSEINA2194_04139 0.0 887.0 COG1263@1|root,COG1264@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,1TPJ8@1239|Firmicutes,24809@186801|Clostridia 186801|Clostridia G pts system nagE - 2.7.1.193 ko:K02803,ko:K02804 ko00520,ko02060,map00520,map02060 M00267 R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7 - - PTS_EIIB,PTS_EIIC LANLAPFM_02671 585394.RHOM_03330 1.04e-265 736.0 COG1653@1|root,COG1653@2|Bacteria,1TRPJ@1239|Firmicutes,24872@186801|Clostridia 186801|Clostridia G ABC-type sugar transport system periplasmic component - - - - - - - - - - - - SBP_bac_8 LANLAPFM_02672 585394.RHOM_03325 4.2e-223 617.0 COG1609@1|root,COG1609@2|Bacteria,1TRFH@1239|Firmicutes,24A4M@186801|Clostridia 186801|Clostridia K lacI family - - - ko:K02529,ko:K03604 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 LANLAPFM_02673 585394.RHOM_09335 4.86e-55 172.0 COG0234@1|root,COG0234@2|Bacteria,1V9ZM@1239|Firmicutes,24MMM@186801|Clostridia 186801|Clostridia O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 LANLAPFM_02674 622312.ROSEINA2194_01367 0.0 956.0 COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,248BG@186801|Clostridia 186801|Clostridia O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 LANLAPFM_02675 585394.RHOM_06790 4.25e-233 644.0 COG0079@1|root,COG0079@2|Bacteria,1TP5D@1239|Firmicutes,248Q0@186801|Clostridia 186801|Clostridia E PFAM Aminotransferase class I and II hisC - 4.1.1.81 ko:K04720 ko00860,map00860 - R06530 RC00517 ko00000,ko00001,ko01000 - - - Aminotran_1_2 LANLAPFM_02676 585394.RHOM_06795 0.0 1230.0 2C1EE@1|root,2Z86R@2|Bacteria,1TS39@1239|Firmicutes,24ABS@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score Rnd - - - - - - - - - - - - LANLAPFM_02677 585394.RHOM_06800 2.23e-177 508.0 28MVQ@1|root,2ZB38@2|Bacteria,1UUTH@1239|Firmicutes,24AV8@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - LANLAPFM_02678 622312.ROSEINA2194_00916 6.06e-72 229.0 2B4WY@1|root,31XPQ@2|Bacteria,1V739@1239|Firmicutes,24IHF@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - LANLAPFM_02679 585394.RHOM_06810 1.1e-157 456.0 28KI7@1|root,2ZA3H@2|Bacteria,1V07J@1239|Firmicutes,24EVH@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02680 411459.RUMOBE_02489 0.0 1114.0 COG4932@1|root,COG4932@2|Bacteria,1TS9Q@1239|Firmicutes,24AX1@186801|Clostridia,3Y1AM@572511|Blautia 186801|Clostridia M LPXTG-motif cell wall anchor domain protein - - - - - - - - - - - - - LANLAPFM_02681 457412.RSAG_00830 8.44e-71 213.0 2BXTH@1|root,2ZZ52@2|Bacteria,1V3TU@1239|Firmicutes,24I3V@186801|Clostridia,3WJS5@541000|Ruminococcaceae 186801|Clostridia S Bacterial protein of unknown function (DUF961) - - - - - - - - - - - - DUF961 LANLAPFM_02682 411459.RUMOBE_02491 2.5e-86 254.0 28NIV@1|root,2ZBK5@2|Bacteria,1V1U5@1239|Firmicutes,24IAF@186801|Clostridia,3Y1IN@572511|Blautia 186801|Clostridia S COG NOG13239 non supervised orthologous group - - - - - - - - - - - - DUF961 LANLAPFM_02684 411459.RUMOBE_02492 0.0 913.0 COG1674@1|root,COG1674@2|Bacteria,1TPHE@1239|Firmicutes,249WR@186801|Clostridia,3Y1AZ@572511|Blautia 186801|Clostridia D COG COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins - - - - - - - - - - - - FtsK_SpoIIIE LANLAPFM_02685 622312.ROSEINA2194_03105 0.0 1384.0 2C1IS@1|root,2Z86T@2|Bacteria,1TQRA@1239|Firmicutes,247QX@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_02686 622312.ROSEINA2194_03106 3.62e-89 262.0 2AGPY@1|root,309PS@2|Bacteria,1V64Q@1239|Firmicutes,24FXN@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02687 622312.ROSEINA2194_03107 5.01e-86 254.0 2AGPY@1|root,316XK@2|Bacteria,1V241@1239|Firmicutes,24GUS@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02688 622312.ROSEINA2194_03108 1.21e-69 213.0 COG0484@1|root,COG0484@2|Bacteria,1VAWE@1239|Firmicutes 1239|Firmicutes O Molecular chaperone dnaJ3 - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ LANLAPFM_02689 622312.ROSEINA2194_03109 1.62e-118 340.0 COG1716@1|root,COG1716@2|Bacteria,1VFJ4@1239|Firmicutes,24Q0H@186801|Clostridia 186801|Clostridia T FHA domain - - - - - - - - - - - - FHA LANLAPFM_02690 622312.ROSEINA2194_03110 2.86e-123 350.0 COG1716@1|root,COG1716@2|Bacteria,1UZ57@1239|Firmicutes,24PC6@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - FHA,Yop-YscD_cpl LANLAPFM_02691 622312.ROSEINA2194_03111 5.16e-184 513.0 COG0631@1|root,COG0631@2|Bacteria,1V094@1239|Firmicutes,24N9G@186801|Clostridia 186801|Clostridia T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2,SpoIIE LANLAPFM_02692 622312.ROSEINA2194_03112 0.0 888.0 COG0631@1|root,COG0631@2|Bacteria,1TQWN@1239|Firmicutes,247KV@186801|Clostridia 186801|Clostridia T Serine/threonine phosphatases, family 2C, catalytic domain - - - - - - - - - - - - SpoIIE LANLAPFM_02693 622312.ROSEINA2194_03113 6.79e-276 757.0 28ISJ@1|root,2Z8RQ@2|Bacteria,1TRGC@1239|Firmicutes,24CC6@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_02694 622312.ROSEINA2194_03114 1.39e-140 399.0 28N97@1|root,2ZBD9@2|Bacteria,1UYY7@1239|Firmicutes,24MD6@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02695 622312.ROSEINA2194_03115 0.0 1659.0 COG0443@1|root,COG0443@2|Bacteria,1TT0Z@1239|Firmicutes,24AG5@186801|Clostridia 186801|Clostridia O Heat shock 70 kDa protein - - - - - - - - - - - - - LANLAPFM_02696 622312.ROSEINA2194_03938 1.07e-136 390.0 28N3U@1|root,2ZB9G@2|Bacteria,1V09T@1239|Firmicutes,2493C@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02697 622312.ROSEINA2194_03937 2.29e-112 322.0 2EFPB@1|root,32SG8@2|Bacteria,1UPYZ@1239|Firmicutes,25HS3@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02698 622312.ROSEINA2194_03936 0.0 889.0 COG3501@1|root,COG3501@2|Bacteria,1V043@1239|Firmicutes,248CZ@186801|Clostridia 186801|Clostridia S Rhs element vgr protein - - - - - - - - - - - - Phage_GPD LANLAPFM_02699 622312.ROSEINA2194_03935 1.09e-143 406.0 2EFPB@1|root,339FB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - LANLAPFM_02700 622312.ROSEINA2194_03934 2.75e-74 227.0 2ER0I@1|root,33IK3@2|Bacteria,1UJZR@1239|Firmicutes,24V5I@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02701 622312.ROSEINA2194_03933 2.12e-120 344.0 2E4BD@1|root,32Z71@2|Bacteria,1VFIN@1239|Firmicutes,24NQT@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02702 1235800.C819_02309 3.39e-41 155.0 2BCEZ@1|root,3260K@2|Bacteria,1URZY@1239|Firmicutes,259XQ@186801|Clostridia,27QI3@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02703 622312.ROSEINA2194_00099 2.06e-38 138.0 2B7HH@1|root,320MM@2|Bacteria,1V7BY@1239|Firmicutes,24KSD@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02704 411469.EUBHAL_00686 2.33e-35 120.0 2EC3Y@1|root,3362U@2|Bacteria,1VF1Z@1239|Firmicutes,24QVE@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02705 411459.RUMOBE_00759 3.67e-46 148.0 2E3HI@1|root,32YG4@2|Bacteria,1VHJH@1239|Firmicutes,24V52@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - LANLAPFM_02706 1256908.HMPREF0373_00535 8.77e-107 322.0 COG1522@1|root,COG2865@1|root,COG1522@2|Bacteria,COG2865@2|Bacteria,1TRTZ@1239|Firmicutes,25CHW@186801|Clostridia,25WTS@186806|Eubacteriaceae 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - AlbA_2,HATPase_c_4,HTH_11,HTH_24 LANLAPFM_02707 1280698.AUJS01000017_gene1837 1.22e-110 331.0 COG1522@1|root,COG2865@1|root,COG1522@2|Bacteria,COG2865@2|Bacteria,1TRTZ@1239|Firmicutes,25CHW@186801|Clostridia,27W54@189330|Dorea 186801|Clostridia K Putative ATP-dependent DNA helicase recG C-terminal - - - - - - - - - - - - AlbA_2,HATPase_c_4,HTH_11,HTH_24 LANLAPFM_02708 1294142.CINTURNW_3431 5.18e-314 867.0 COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,249PY@186801|Clostridia,36DVT@31979|Clostridiaceae 186801|Clostridia J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit LANLAPFM_02709 585394.RHOM_03115 1.01e-64 199.0 COG1917@1|root,COG1917@2|Bacteria,1VCF2@1239|Firmicutes,25BAE@186801|Clostridia 186801|Clostridia S Cupin domain - - - - - - - - - - - - Cupin_2 LANLAPFM_02710 622312.ROSEINA2194_02021 4.96e-189 535.0 COG0738@1|root,COG0738@2|Bacteria,1UZWI@1239|Firmicutes,24H3U@186801|Clostridia 186801|Clostridia G Major Facilitator - - - - - - - - - - - - MFS_1 LANLAPFM_02711 585394.RHOM_03110 4.45e-162 462.0 COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,24BWQ@186801|Clostridia 186801|Clostridia G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - - - - - - - - - - DctP LANLAPFM_02712 585394.RHOM_03105 1.83e-111 329.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V1DC@1239|Firmicutes,24GJV@186801|Clostridia 186801|Clostridia KT response regulator - - - - - - - - - - - - HTH_18,HTH_AraC,Response_reg LANLAPFM_02713 585394.RHOM_03100 6.86e-217 615.0 COG2972@1|root,COG2972@2|Bacteria,1TSF9@1239|Firmicutes,2499Y@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,His_kinase LANLAPFM_02714 585394.RHOM_03095 2.18e-60 191.0 2CPN3@1|root,32SJG@2|Bacteria,1VASE@1239|Firmicutes,24KG6@186801|Clostridia 186801|Clostridia S YcxB-like protein - - - - - - - - - - - - YcxB LANLAPFM_02715 585394.RHOM_03090 9.42e-268 738.0 COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia 186801|Clostridia G Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DctM LANLAPFM_02716 585394.RHOM_03085 4.56e-100 292.0 COG3090@1|root,COG3090@2|Bacteria,1V1US@1239|Firmicutes,24G5M@186801|Clostridia 186801|Clostridia G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ LANLAPFM_02717 585394.RHOM_03080 5.67e-217 605.0 COG1638@1|root,COG1638@2|Bacteria,1TSSW@1239|Firmicutes,24DW9@186801|Clostridia 186801|Clostridia G TRAP transporter solute receptor, DctP family - - - - - - - - - - - - DctP,TAT_signal LANLAPFM_02718 478749.BRYFOR_06633 1.71e-151 429.0 COG0730@1|root,COG0730@2|Bacteria,1TRFG@1239|Firmicutes,24AEX@186801|Clostridia 186801|Clostridia S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE LANLAPFM_02719 411459.RUMOBE_02060 8.38e-63 196.0 COG1846@1|root,COG1846@2|Bacteria,1V749@1239|Firmicutes,24KYW@186801|Clostridia 186801|Clostridia K Transcriptional regulator, MarR family - - - - - - - - - - - - MarR_2 LANLAPFM_02720 622312.ROSEINA2194_02511 6.03e-239 665.0 COG0615@1|root,COG2513@1|root,COG0615@2|Bacteria,COG2513@2|Bacteria,1TQVY@1239|Firmicutes,24AC5@186801|Clostridia 186801|Clostridia GM phosphoenolpyruvate aepX - 5.4.2.9 ko:K01841 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 - R00661 RC02792 ko00000,ko00001,ko01000 - - - CTP_transf_like,NTP_transf_3,PEP_mutase LANLAPFM_02721 1280692.AUJL01000001_gene306 1e-149 434.0 COG0028@1|root,COG0028@2|Bacteria,1TSJZ@1239|Firmicutes,24AIU@186801|Clostridia,36F1Y@31979|Clostridiaceae 186801|Clostridia EH Thiamine pyrophosphate enzyme, N-terminal TPP binding domain aepY - 4.1.1.82 ko:K09459 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 - R04053 RC00506 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_N LANLAPFM_02722 397287.C807_02814 5.77e-56 182.0 COG4750@1|root,COG4750@2|Bacteria,1UYW1@1239|Firmicutes,25CE0@186801|Clostridia,27M9E@186928|unclassified Lachnospiraceae 186801|Clostridia M MobA-like NTP transferase domain - - - - - - - - - - - - APH,HTH_24,NTP_transf_3,NTP_transferase LANLAPFM_02724 585394.RHOM_03660 7.6e-111 323.0 28PNE@1|root,2ZCB6@2|Bacteria,1V214@1239|Firmicutes,24DN2@186801|Clostridia 186801|Clostridia S COG NOG11305 non supervised orthologous group spoVAA - - ko:K06403 - - - - ko00000 - - - SporV_AA LANLAPFM_02725 585394.RHOM_03665 8.16e-55 176.0 2AF43@1|root,3152T@2|Bacteria,1VFMI@1239|Firmicutes,24RBI@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K06404 - - - - ko00000 - - - SpoVAB LANLAPFM_02726 585394.RHOM_03670 1.25e-43 147.0 2EJW5@1|root,33DKW@2|Bacteria,1VPSK@1239|Firmicutes,24W6H@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF3837) - - - - - - - - - - - - DUF3837 LANLAPFM_02728 318464.IO99_03650 2.37e-45 154.0 COG3177@1|root,COG3177@2|Bacteria,1TZWX@1239|Firmicutes,247MZ@186801|Clostridia,36FX9@31979|Clostridiaceae 186801|Clostridia K Filamentation induced by cAMP protein fic - - - - - - - - - - - - Fic LANLAPFM_02729 585394.RHOM_08855 2.52e-76 228.0 COG1302@1|root,COG1302@2|Bacteria,1V4IC@1239|Firmicutes,24JNM@186801|Clostridia 186801|Clostridia S protein conserved in bacteria asp - - - - - - - - - - - Asp23 LANLAPFM_02730 622312.ROSEINA2194_02748 4.43e-42 142.0 COG0781@1|root,COG0781@2|Bacteria,1VA9B@1239|Firmicutes,24MQ3@186801|Clostridia 186801|Clostridia K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB LANLAPFM_02731 622312.ROSEINA2194_02747 5.74e-202 569.0 COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,247KE@186801|Clostridia 186801|Clostridia L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 LANLAPFM_02732 622312.ROSEINA2194_02746 1.32e-20 84.0 COG1722@1|root,COG1722@2|Bacteria 2|Bacteria L exodeoxyribonuclease VII activity xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S LANLAPFM_02733 585394.RHOM_08835 2.13e-161 457.0 COG0142@1|root,COG0142@2|Bacteria,1TPQY@1239|Firmicutes,248DE@186801|Clostridia 186801|Clostridia H Belongs to the FPP GGPP synthase family ispA - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - iHN637.CLJU_RS05465 polyprenyl_synt LANLAPFM_02734 585394.RHOM_08830 0.0 1061.0 COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia 186801|Clostridia H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C LANLAPFM_02735 622312.ROSEINA2194_02743 3.04e-154 437.0 COG1189@1|root,COG1189@2|Bacteria,1TPE4@1239|Firmicutes,247VH@186801|Clostridia 186801|Clostridia J Ribosomal RNA large subunit methyltransferase J rrmJ - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 LANLAPFM_02736 622312.ROSEINA2194_02742 4.85e-138 398.0 COG0061@1|root,COG0061@2|Bacteria,1TRB3@1239|Firmicutes,24BG6@186801|Clostridia 186801|Clostridia H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS05480 NAD_kinase LANLAPFM_02737 622312.ROSEINA2194_02741 1.05e-80 241.0 COG1438@1|root,COG1438@2|Bacteria,1V1R7@1239|Firmicutes,24HGQ@186801|Clostridia 186801|Clostridia K Regulates arginine biosynthesis genes argR - - ko:K03402 - - - - ko00000,ko03000 - - - Arg_repressor,Arg_repressor_C LANLAPFM_02738 585394.RHOM_08810 4.64e-148 436.0 COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,247KB@186801|Clostridia 186801|Clostridia L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N LANLAPFM_02739 622312.ROSEINA2194_02739 9.26e-109 318.0 COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,247KB@186801|Clostridia 186801|Clostridia L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N LANLAPFM_02740 585394.RHOM_08805 5.79e-162 468.0 COG3480@1|root,COG3480@2|Bacteria,1UI0S@1239|Firmicutes,25E9E@186801|Clostridia 186801|Clostridia T Stage IV sporulation protein B spoIVB - 3.4.21.116 ko:K06399 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S55 LANLAPFM_02741 585394.RHOM_08800 3.25e-155 457.0 COG0457@1|root,COG2199@1|root,COG0457@2|Bacteria,COG3706@2|Bacteria,1TS77@1239|Firmicutes,24E4N@186801|Clostridia 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - GGDEF,TPR_8 LANLAPFM_02742 585394.RHOM_08795 3.17e-154 437.0 COG2201@1|root,COG2201@2|Bacteria,1VQS3@1239|Firmicutes,25E3X@186801|Clostridia 186801|Clostridia NT May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process spo0A - - ko:K03413,ko:K07699 ko02020,ko02024,ko02030,map02020,map02024,map02030 M00485,M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg,Spo0A_C LANLAPFM_02743 622312.ROSEINA2194_02735 2.95e-285 788.0 COG0297@1|root,COG0297@2|Bacteria,1TQ4M@1239|Firmicutes,248G1@186801|Clostridia 186801|Clostridia G Synthesizes alpha-1,4-glucan chains using ADP-glucose - - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 LANLAPFM_02744 585394.RHOM_08680 2.61e-108 325.0 28PM6@1|root,2ZCAA@2|Bacteria,1V4NT@1239|Firmicutes,24HIP@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - LANLAPFM_02745 411489.CLOL250_02627 2.17e-314 863.0 COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,36DX4@31979|Clostridiaceae 186801|Clostridia J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon,tRNA_bind LANLAPFM_02746 585394.RHOM_15670 3.44e-93 274.0 COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,24HP9@186801|Clostridia 186801|Clostridia K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N LANLAPFM_02747 622312.ROSEINA2194_00784 4.33e-54 177.0 2ECHQ@1|root,336FZ@2|Bacteria,1VI4C@1239|Firmicutes,24TFT@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02748 622312.ROSEINA2194_00783 1.47e-204 569.0 COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia 186801|Clostridia J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dus - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus LANLAPFM_02749 585394.RHOM_15685 3.89e-170 477.0 COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia 186801|Clostridia F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase LANLAPFM_02750 585394.RHOM_15690 8.34e-61 188.0 2CJXG@1|root,32SB0@2|Bacteria,1VAFJ@1239|Firmicutes,24MNI@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - LANLAPFM_02751 622312.ROSEINA2194_00780 6.6e-177 499.0 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia 186801|Clostridia HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 LANLAPFM_02752 585394.RHOM_15700 7.31e-222 613.0 COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia 186801|Clostridia E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N LANLAPFM_02753 622312.ROSEINA2194_00777 1.13e-127 375.0 COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,248MP@186801|Clostridia 186801|Clostridia O SPFH Band 7 PHB domain protein qmcA - - - - - - - - - - - Band_7 LANLAPFM_02754 585394.RHOM_14185 1.09e-117 348.0 COG0392@1|root,COG0392@2|Bacteria,1V2TI@1239|Firmicutes,24K1U@186801|Clostridia 186801|Clostridia S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms mprF - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM LANLAPFM_02755 622312.ROSEINA2194_04045 0.0 916.0 COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia 186801|Clostridia C Radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM LANLAPFM_02756 585394.RHOM_14195 8.62e-148 425.0 COG0770@1|root,COG0770@2|Bacteria,1TS8M@1239|Firmicutes,24CJW@186801|Clostridia 186801|Clostridia M Zinc dependent phospholipase C - - - - - - - - - - - - Zn_dep_PLPC LANLAPFM_02757 585394.RHOM_14200 2.18e-185 520.0 COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,248UR@186801|Clostridia 186801|Clostridia CH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C LANLAPFM_02758 585394.RHOM_14205 6.14e-154 437.0 COG4667@1|root,COG4667@2|Bacteria,1TQ9W@1239|Firmicutes,2485C@186801|Clostridia 186801|Clostridia S Phospholipase, patatin family - - - - - - - - - - - - Patatin LANLAPFM_02759 622312.ROSEINA2194_04052 1.34e-61 194.0 COG1585@1|root,COG1585@2|Bacteria,1VAS9@1239|Firmicutes,24MRQ@186801|Clostridia 186801|Clostridia OU Psort location CytoplasmicMembrane, score - - - - - - - - - - - - NfeD LANLAPFM_02760 585394.RHOM_14215 1.08e-53 180.0 2DU28@1|root,33NME@2|Bacteria,1VMV6@1239|Firmicutes,24V3C@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02761 585394.RHOM_14220 1.96e-194 546.0 COG1619@1|root,COG1619@2|Bacteria,1TZSN@1239|Firmicutes,25CIH@186801|Clostridia 186801|Clostridia V proteins homologs of microcin C7 resistance protein MccF - - - - - - - - - - - - Peptidase_S66 LANLAPFM_02762 642492.Clole_3044 1.68e-139 432.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia 186801|Clostridia NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,dCache_1 LANLAPFM_02764 585394.RHOM_00540 1.03e-186 521.0 COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,248RY@186801|Clostridia 186801|Clostridia J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD LANLAPFM_02766 585394.RHOM_00550 5.24e-72 233.0 COG2385@1|root,COG2385@2|Bacteria,1TQSI@1239|Firmicutes,249H0@186801|Clostridia 186801|Clostridia D stage II sporulation protein D spoIID - - ko:K06381 - - - - ko00000 - - - SpoIID LANLAPFM_02767 622312.ROSEINA2194_00437 5.41e-90 274.0 COG0739@1|root,COG0739@2|Bacteria,1VATR@1239|Firmicutes,24N76@186801|Clostridia 186801|Clostridia M COG COG0739 Membrane proteins related to metalloendopeptidases - - - - - - - - - - - - Peptidase_M23 LANLAPFM_02768 585394.RHOM_00560 3.89e-203 583.0 COG0457@1|root,COG2199@1|root,COG0457@2|Bacteria,COG3706@2|Bacteria,1TS77@1239|Firmicutes,24E4N@186801|Clostridia 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - GGDEF,sCache_3_3 LANLAPFM_02769 585394.RHOM_00565 0.0 964.0 COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia 186801|Clostridia L Belongs to the DEAD box helicase family cshA - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C LANLAPFM_02770 585394.RHOM_13945 1.01e-262 727.0 COG0534@1|root,COG0534@2|Bacteria,1TP5P@1239|Firmicutes,247PQ@186801|Clostridia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - MatE LANLAPFM_02771 585394.RHOM_00590 2.5e-141 401.0 COG0745@1|root,COG0745@2|Bacteria,1TP9M@1239|Firmicutes,247TK@186801|Clostridia 186801|Clostridia KT response regulator receiver - - - - - - - - - - - - Response_reg,Trans_reg_C LANLAPFM_02772 397291.C804_00768 1.83e-187 567.0 COG0642@1|root,COG2205@2|Bacteria,1TP73@1239|Firmicutes,248Y6@186801|Clostridia,27ICQ@186928|unclassified Lachnospiraceae 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA LANLAPFM_02773 585394.RHOM_14445 1.41e-65 202.0 2DM5I@1|root,31T37@2|Bacteria,1V6J6@1239|Firmicutes,24K9S@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - SseB LANLAPFM_02774 585394.RHOM_14420 1.44e-122 350.0 COG1592@1|root,COG1592@2|Bacteria,1TSUY@1239|Firmicutes,248GY@186801|Clostridia 186801|Clostridia C Psort location Cytoplasmic, score rbr3A - - - - - - - - - - - Rubrerythrin LANLAPFM_02775 585394.RHOM_02525 1.77e-282 772.0 COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia 186801|Clostridia P Ammonium Transporter amt - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp,P-II LANLAPFM_02776 585394.RHOM_02520 9.27e-66 201.0 COG0347@1|root,COG0347@2|Bacteria,1V9Z5@1239|Firmicutes,24MNA@186801|Clostridia 186801|Clostridia K Belongs to the P(II) protein family glnB1 - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II LANLAPFM_02777 585394.RHOM_02515 0.0 1231.0 COG3968@1|root,COG3968@2|Bacteria,1UHUF@1239|Firmicutes,2481B@186801|Clostridia 186801|Clostridia S glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - GSIII_N,Gln-synt_C LANLAPFM_02778 585394.RHOM_02510 1.4e-201 558.0 COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia 186801|Clostridia G Fructose-1,6-bisphosphate aldolase, class II fba - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase LANLAPFM_02779 585394.RHOM_02505 7.65e-182 509.0 COG1597@1|root,COG1597@2|Bacteria,1TQAU@1239|Firmicutes,249SY@186801|Clostridia 186801|Clostridia I lipid kinase, YegS Rv2252 BmrU family dagK - - - - - - - - - - - DAGK_cat LANLAPFM_02780 585394.RHOM_02500 6.4e-30 108.0 COG1925@1|root,COG1925@2|Bacteria 2|Bacteria G phosphoenolpyruvate-dependent sugar phosphotransferase system ptsH - - ko:K11184,ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr LANLAPFM_02781 622312.ROSEINA2194_03472 6.05e-145 416.0 COG1481@1|root,COG1481@2|Bacteria,1TP2X@1239|Firmicutes,2484M@186801|Clostridia 186801|Clostridia K May be required for sporulation whiA - - ko:K09762 - - - - ko00000 - - - HTH_WhiA,LAGLIDADG_WhiA,WhiA_N LANLAPFM_02782 585394.RHOM_02490 4.44e-179 502.0 COG1660@1|root,COG1660@2|Bacteria,1TPS4@1239|Firmicutes,248KQ@186801|Clostridia 186801|Clostridia S Displays ATPase and GTPase activities yvcJ - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 LANLAPFM_02783 585394.RHOM_02485 3.53e-137 397.0 COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia 186801|Clostridia M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C LANLAPFM_02784 585394.RHOM_02480 5.51e-302 827.0 COG1362@1|root,COG1362@2|Bacteria,1TP6G@1239|Firmicutes,2486Y@186801|Clostridia 186801|Clostridia E M18 family aminopeptidase apeA - - - - - - - - - - - Peptidase_M18 LANLAPFM_02785 585394.RHOM_02475 2.69e-207 575.0 COG1493@1|root,COG1493@2|Bacteria,1TP5Z@1239|Firmicutes,24999@186801|Clostridia 186801|Clostridia T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N LANLAPFM_02786 585394.RHOM_02470 0.0 1092.0 COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia 186801|Clostridia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N LANLAPFM_02787 585394.RHOM_02465 0.0 1093.0 COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,247WQ@186801|Clostridia 186801|Clostridia O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 LANLAPFM_02788 622312.ROSEINA2194_02123 2.3e-44 144.0 COG1609@1|root,COG1609@2|Bacteria,1VADF@1239|Firmicutes,24MXI@186801|Clostridia 186801|Clostridia K sporulation transcriptional regulator SpoIIID spoIIID - - ko:K06283 - - - - ko00000,ko03000 - - - SpoIIID LANLAPFM_02790 1410628.JNKS01000007_gene1428 1.09e-12 67.8 2BZT8@1|root,32W5F@2|Bacteria,1UGQC@1239|Firmicutes,24Q23@186801|Clostridia,27RY9@186928|unclassified Lachnospiraceae 186801|Clostridia S Protein of unknown function (DUF4230) - - - - - - - - - - - - DUF4230 LANLAPFM_02791 1280698.AUJS01000027_gene2309 3.26e-133 421.0 COG1196@1|root,COG1196@2|Bacteria,1UJ26@1239|Firmicutes,25EV1@186801|Clostridia,27WJD@189330|Dorea 186801|Clostridia D Penicillin-binding protein Tp47 domain a - - - - - - - - - - - - DUF1533,FIVAR,FMN_bind,PBP-Tp47_a,PBP-Tp47_c LANLAPFM_02792 742765.HMPREF9457_00195 3.41e-38 140.0 COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,27WG2@189330|Dorea 186801|Clostridia C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_5 LANLAPFM_02793 742765.HMPREF9457_00196 3.75e-38 133.0 COG3976@1|root,COG3976@2|Bacteria,1VENM@1239|Firmicutes,24RRX@186801|Clostridia,27WZB@189330|Dorea 186801|Clostridia S FMN_bind - - - - - - - - - - - - FMN_bind LANLAPFM_02794 411462.DORLON_02377 1.75e-71 247.0 COG3976@1|root,COG3976@2|Bacteria,1TR5A@1239|Firmicutes,25E6J@186801|Clostridia,27VY2@189330|Dorea 186801|Clostridia S FMN_bind - - - - - - - - - - - - FMN_bind,Fer4_5 LANLAPFM_02795 411462.DORLON_02376 1.32e-141 412.0 COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,248KJ@186801|Clostridia,27WEW@189330|Dorea 186801|Clostridia H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE LANLAPFM_02796 622312.ROSEINA2194_00831 1.15e-97 290.0 COG4684@1|root,COG4684@2|Bacteria,1V2ZW@1239|Firmicutes 1239|Firmicutes S ECF transporter, substrate-specific component - - - - - - - - - - - - ECF_trnsprt LANLAPFM_02797 622312.ROSEINA2194_00831 1.85e-91 273.0 COG4684@1|root,COG4684@2|Bacteria,1V2ZW@1239|Firmicutes 1239|Firmicutes S ECF transporter, substrate-specific component - - - - - - - - - - - - ECF_trnsprt LANLAPFM_02798 1408324.JNJK01000020_gene3693 5.02e-19 92.0 COG4412@1|root,COG4412@2|Bacteria,1VJS1@1239|Firmicutes,24RVX@186801|Clostridia,27QA4@186928|unclassified Lachnospiraceae 186801|Clostridia S M6 family metalloprotease domain protein - - - - - - - - - - - - - LANLAPFM_02799 1384066.JAGT01000001_gene2174 1.62e-12 70.5 COG3291@1|root,COG4412@1|root,COG3291@2|Bacteria,COG4412@2|Bacteria,1TTH2@1239|Firmicutes,258XS@186801|Clostridia,3WP03@541000|Ruminococcaceae 186801|Clostridia S Pkd domain containing protein - - - - - - - - - - - - - LANLAPFM_02800 622312.ROSEINA2194_04074 1.41e-240 662.0 COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia 186801|Clostridia C electron transfer flavoprotein etfA - 1.3.1.108 ko:K03522,ko:K22432 - - - - ko00000,ko01000,ko04147 - - - ETF,ETF_alpha LANLAPFM_02801 622312.ROSEINA2194_04075 9.33e-179 498.0 COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia 186801|Clostridia C electron transfer flavoprotein etfB - - ko:K03521 - - - - ko00000 - - - ETF LANLAPFM_02802 585394.RHOM_02775 4.52e-262 719.0 COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia 186801|Clostridia C acyl-CoA dehydrogenase bcd - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N LANLAPFM_02803 585394.RHOM_02770 2.14e-199 553.0 COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,248AE@186801|Clostridia 186801|Clostridia I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain hbd - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N LANLAPFM_02804 622312.ROSEINA2194_04078 1.26e-268 737.0 COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia 186801|Clostridia I Belongs to the thiolase family thlA - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N LANLAPFM_02805 622312.ROSEINA2194_02238 1e-118 350.0 COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1UXKB@1239|Firmicutes,24DXK@186801|Clostridia 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18 LANLAPFM_02806 585394.RHOM_07120 1.2e-195 545.0 COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia 186801|Clostridia J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS LANLAPFM_02807 585394.RHOM_07115 2.87e-164 461.0 COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,247ZR@186801|Clostridia 186801|Clostridia J Belongs to the universal ribosomal protein uS2 family rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 LANLAPFM_02808 622312.ROSEINA2194_00984 1.59e-46 158.0 COG1559@1|root,COG1559@2|Bacteria,1VF4Y@1239|Firmicutes,24RCQ@186801|Clostridia 186801|Clostridia S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation - - - - - - - - - - - - YceG LANLAPFM_02809 585394.RHOM_07105 7.12e-57 187.0 COG3064@1|root,COG3064@2|Bacteria,1V968@1239|Firmicutes,24KD3@186801|Clostridia 186801|Clostridia M Membrane - - - - - - - - - - - - - LANLAPFM_02810 585394.RHOM_07100 1.1e-32 117.0 2ECFD@1|root,336DM@2|Bacteria,1VHDX@1239|Firmicutes,24TE9@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02811 622312.ROSEINA2194_00979 2.28e-133 383.0 COG1191@1|root,COG1191@2|Bacteria,1TP9K@1239|Firmicutes,248M0@186801|Clostridia 186801|Clostridia K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 LANLAPFM_02812 585394.RHOM_07090 3.96e-22 89.4 2E8TH@1|root,33348@2|Bacteria,1VJ8V@1239|Firmicutes,24SQI@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - LANLAPFM_02813 585394.RHOM_07085 4.4e-101 294.0 COG1871@1|root,COG1871@2|Bacteria,1V70X@1239|Firmicutes,24HH7@186801|Clostridia 186801|Clostridia NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis cheD - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD LANLAPFM_02814 585394.RHOM_07080 1.03e-121 350.0 COG1776@1|root,COG1776@2|Bacteria,1UNKB@1239|Firmicutes,247MX@186801|Clostridia 186801|Clostridia NT Chemotaxis protein CheC, inhibitor of MCP methylation cheC - - ko:K03410 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheC LANLAPFM_02815 585394.RHOM_07075 3.02e-79 238.0 COG0835@1|root,COG0835@2|Bacteria,1V4HH@1239|Firmicutes,24JV4@186801|Clostridia 186801|Clostridia NT PFAM CheW domain protein - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW LANLAPFM_02816 585394.RHOM_07070 0.0 1069.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia 186801|Clostridia T Signal transducing histidine kinase homodimeric cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,P2 LANLAPFM_02817 622312.ROSEINA2194_00972 6.51e-190 535.0 COG2201@1|root,COG2201@2|Bacteria,1TRHC@1239|Firmicutes,249FD@186801|Clostridia 186801|Clostridia NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg LANLAPFM_02818 622312.ROSEINA2194_00971 1.57e-86 264.0 COG5581@1|root,COG5581@2|Bacteria,1VCR9@1239|Firmicutes 1239|Firmicutes M Flagellar protein YcgR - - - - - - - - - - - - PilZ,YcgR_2 LANLAPFM_02819 1235790.C805_01994 1.86e-120 353.0 COG0455@1|root,COG0455@2|Bacteria,1TRZ5@1239|Firmicutes,24AIN@186801|Clostridia,25VBY@186806|Eubacteriaceae 186801|Clostridia D 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family flhG - - ko:K04562 - - - - ko00000,ko02035 - - - CbiA,ParA LANLAPFM_02820 585394.RHOM_07050 9.82e-194 550.0 COG1419@1|root,COG1419@2|Bacteria,1TSP7@1239|Firmicutes,249R1@186801|Clostridia 186801|Clostridia N PFAM GTP-binding signal recognition particle SRP54 G- domain flhF - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 LANLAPFM_02821 622312.ROSEINA2194_00968 0.0 1124.0 COG1298@1|root,COG1298@2|Bacteria,1TQBM@1239|Firmicutes,248F5@186801|Clostridia 186801|Clostridia N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP LANLAPFM_02822 622312.ROSEINA2194_00967 1.47e-56 186.0 COG1377@1|root,COG1377@2|Bacteria,1TPRP@1239|Firmicutes,248N7@186801|Clostridia 186801|Clostridia N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401,ko:K13820 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1,Bac_export_2 LANLAPFM_02823 622312.ROSEINA2194_04268 0.0 1033.0 COG0366@1|root,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.133,3.2.1.135,3.2.1.54 ko:K01208 ko00500,ko01100,map00500,map01100 - R02112,R03122,R11262 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Alpha-amylase_N,Malt_amylase_C LANLAPFM_02824 1408306.JHXX01000004_gene307 1.56e-18 86.3 COG2909@1|root,COG4637@1|root,COG2909@2|Bacteria,COG4637@2|Bacteria,1TQ9X@1239|Firmicutes,247NI@186801|Clostridia,4BWYE@830|Butyrivibrio 186801|Clostridia K PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - AAA-ATPase_like,PDDEXK_9 ## 2588 queries scanned ## Total time (seconds): 409.2552218437195 ## Rate: 6.32 q/s