LOCUS       gnlProkkaHCKKCODJ_22   10279 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HCKKCODJ_22.
ACCESSION   gnlProkkaHCKKCODJ_22
VERSION     gnlProkkaHCKKCODJ_22
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 05:01:01
            Original ID  :: gnl|Prokka|HCKKCODJ_22
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10279
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10279
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2:279]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3..279
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..10279
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10279
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             complement(3..65)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_1"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 5.2e-10,
                     bitscore: 29.4, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVHQYQLNGYNIVLDTCSGSV"
     CDS             complement(133..279)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_2"
                     /sec_met_domain="TIGR03973 (E-value: 1.4e-26, bitscore:
                     82.1, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 8.1e-26, bitscore: 79.7,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERIKTIATRDLTKSVKTGGCGECQTSCQSACKTSCGVANQQCEN
                     SNK"
     CDS             complement(400..687)
                     /locus_tag="ctg22_3"
                     /transl_table=11
                     /translation="MPERTTQNAQTLLSPRVPRDTEHERYHPELEEELKECLFCLKRNE
                     MMFDMEVDTDLIEQRIYERQALLCRYRYLLARARELGLHTVLTRYQPMGG"
     CDS             complement(1124..2884)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1283:2`,3`-cyclic-nucleotide 2`-phosphodiesterase
                     (Score: 253.3; E-value: 8.5e-77)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_4"
                     /transl_table=11
                     /translation="MKQLISRRSFLKAAGVTAAAASMAIGAPAASACWYGDKSDVTILY
                     TNDVHTYIDKQSPKLTYAAIADLKQSYQNAGKDVLLVDAGDHVQGTAYGSMDEGASIIK
                     LMNAAGYDVATPGNHEFDYGMDRAKAIMKEADFPYLSCNWVDLRTTLRVLPSVKVFVRG
                     GRRIAFVGVTTPETFTKSTPAYFMDKAQRKYIYDIQGGEDGKKLYDAVQKAIDKAKLLA
                     DVVIGLGHLGVDPSSSPWTSEEVIAHTSGFDAFIDGHSHTVMENKQVQDASGKAVTLTQ
                     TGSYFANVGEMTIAADGTITTKLIPTHEGMDAGIAAMQTGWVNTVDDMLGEKIAVGDSD
                     FYVSDPATGKRRIRSAETNLGDFVADGIYTYFNEVEKLHCDVAIMNGGGIRADVPAGDW
                     TFKTCKQVSPFGNVACLMSVTGKQIQDALEFAARFAGEDGKENGGFLQVAGATYEIHTD
                     IPNTVQTDEKNVWIGSATGTPRVQNVKIYDKASGSYLPLDPGATYALAGMNYTLRNLGD
                     GFAMFDGAELIKDYVSEDYLVMSTYAMIFDGADAAGLPHLSSANSPLAAYPGYLLNYEQ
                     PYGAGRITIL"
     CDS             complement(3172..4944)
                     /locus_tag="ctg22_5"
                     /transl_table=11
                     /translation="MYYSSGNYEAFAHPKKPEGVDHKSAYIIGSGLAALTAACYLVRDG
                     QMKGEHVHVFEKNALAGGACDGYKYDIGYVMRGGREMDNHFEVMWDLLHSIPSLETEGA
                     SVLDEYYWLNKEDPNFSLCRATVNRGEDAHTDGKFGLSDKGAMEIMKLFFTPDEQLQDK
                     KITDFFDDEVLNTNFWMYWRTMFAFENWHSALEMKLYLKRYIHHIGGLPDFTALRFTRY
                     NQYESIILPMVRYLEGFGVQFHYNTKVTDVKFDIQKGRKLASSVTVEHAGETSNIDLTE
                     NDLLFITNGGCVESCTVGAQDKATGFDPTIQPGNGWDLWKKIAAQDPSFGHPEKFCSEP
                     ELSNWESATITTLDDKIPQYIRKICKRDPFSGHTVTGGIVTVKDSSWLLSWTLNRQQQF
                     KDQPKNQLCVWVYGLFSDKPGDYVKKPMRDCTGREICMEWLYHIGVPEDQIAELAEHSA
                     NTVPVMMPYIDAFFMPRAMGDRPDVVPEGAVNFAFLGQFAETARDTIFTTEYSMRTGME
                     AVYTLLNIDRGVPEVWGSTYDVRALIDATVKLRDGKKITDMDLPLIPRLALKEALKKIE
                     GTDLEKFLKEYNAI"
     CDS             complement(5312..5575)
                     /locus_tag="ctg22_6"
                     /transl_table=11
                     /translation="MSKEFSFPNKGTCSKQTNFVLNDDHTISSIEVIGGCNGNLKGICQ
                     LLTGMKAEDAIARLDGTLCGFRSTSCPDQIAKNLKKALEQMN"
     CDS             complement(5581..6441)
                     /locus_tag="ctg22_7"
                     /transl_table=11
                     /translation="MSCDLHIHSTCSDGAVPIERLAPIAARTGLHAIALSDHDTLLSAQ
                     YAYAHTGQDGVELIPAVELTGYDFERQHRVHLLCYYPDVDCPALREHCAIMKERRNACA
                     LQSAKELEQLYPQFTTDLAWETTKASGVLFKSGLMQALELLGLTDGSIYGETYHKLFGW
                     NPRGIVLHSPEYLPVRQVLATAKASGGAVVFAHPTVYKSMPLLRELAAEGAVDGIEVYH
                     PSNSPEDSAECLALCKQYGLVATAGTDFHGRNHKHPHPIGTCTAPDEAAAQLRAIAEKR
                     KRERT"
     CDS             complement(6456..8732)
                     /locus_tag="ctg22_8"
                     /transl_table=11
                     /translation="MLDMIKCSTGGAYYARGEWVPADGNAPAALAAKGFDAAAVAAAKT
                     GTMAYNIMQAHNTSGDAENLKIKFDAMASHDITFVGIIQTARASGLEKFPIPYVLTNCH
                     NSLCAVGGTINEDDHRFGLSAAKKYGGIFVPPHMAVIHQYMRERFAGCGKMILGSDSHT
                     RYGALGTMAIGEGGGELAKQLLGRTYDVARPGVVAIYLTGSLPVGCGPHDVAIALVGKL
                     FKSGYVKNKVMEFVGPGIASLRQDTRNAIDAMTTETTCLSSIWETDEVTQRFLAVHGRA
                     ADYKKLAPADLAYYDGVVEVDLSAIRPMIALPMHPSNAFTIEELNANLEDILHACEQDV
                     QKLIGRKDVQLDLCSKIENGKLRVDQGVIAGCAGGLYDSIYEAASILKGHTGGCGDYAL
                     SVYPGSQPIMMELVRTGVIGELMASGATIRTAFCGPCFGAGDVPANGALSIRHTTRNFP
                     SREGSKPGSGQLAGVALMDARSIAATTANGGILTPATDIDYDPTVPEYQYDASSYDTRV
                     YQGFGKGDYDALLKFGPNIKDWPEIAPLGDNLLLKVASYITDPVTTTDELIPSGETSSY
                     RSNPLGLAEFTLSRKDPEYVGRAKAVQAEENARRAGAGDAALLAKVNAVPGCEKLSWND
                     IQIASTIFAVKPGDGSAREQAASCQRVLGAGANIVTEYATKRYRSNLINWGMLPLQLAG
                     ATPFGLGDYVLIPNVREALKGDLQNIKAYVLGDTVKEFELYMAPLTTDERQILADGCLI
                     NFYKH"
ORIGIN
        1 tgcaccgagc cgctgcaggt gtccagcacg atgttataac cgttcaattg atactgatgt
       61 accattttac actccattcc agattacaca aaaaaatgcc gcccggcaaa ggcggcataa
      121 ggtttgcaaa aattacttgt tgctgttctc gcactgctgg ttagccacgc cgcaggaggt
      181 cttgcaggcg gactggcagg aagtctggca ctcgccgcag ccaccggtct taacgctctt
      241 ggtcaggtca cgagtagcaa tagtcttaat acgctccatg atagaaacct ctctaactct
      301 caaaaattta tcgcgccgga caaagttccg gtacgctttt atcttgtaat aggatatcac
      361 gcagcgcgcc ttttgtcaag attttttcgc tgaccgtttt cacccgccca tgggctggta
      421 gcgggtaagc accgtatgca gccccagttc ccgggcgcgc gccagtaagt accggtagcg
      481 gcacagcagc gcctgccgct cgtagatgcg ctgctcgatc aggtccgtat ccacctccat
      541 atcaaacatc atctcgttgc gcttcaaaca gaacaggcat tccttcagtt cctcctccag
      601 ttccgggtgg tagcgctcgt gctcggtatc ccgcgggacg cggggcgaaa gcagggtctg
      661 ggcattctgt gtggttcgtt ccggcatagg catcctcctt ctggtacatt gcaaggtttt
      721 gtaccttcca gtataggcgg tgcggtgcgc agaatacgcc gaagcgtggc agcgctccgg
      781 catagattat ccggcgctgc tgcggcattt tccaaaaaag tacaactttt ttcaaaaata
      841 tgcttgacaa ctccgggctt ttcccgtata atagcacacg ttgagcggct caccccgcaa
      901 aacacaacag aatattgggg atttgcatag tggtagtgcg gtagactctg actctacttg
      961 tgggagttcg attctctcat ccccaaccag aacaaagcca tctgaggaaa ctcaggtggc
     1021 ttttctgttt gtatgattcc gcgcggaaaa aatattatag atagagcgaa cccggaaagt
     1081 ccgcaggact ttccgggttc gccttttcac gggaaatata aatttacaga atggtaatgc
     1141 ggcctgcgcc gtagggctgc tcgtagttga gcaggtagcc ggggtaagcg gccagcgggc
     1201 tgttggcgct ggacaggtgc ggcagacccg cagcatctgc gccgtcaaaa atcatagcgt
     1261 aggtagacat gaccagataa tcctcggaca catagtcctt gatcagctct gcgccgtcaa
     1321 acatggcaaa gccgtcgccc agattgcgca gggtgtagtt catgccggcc agtgcgtagg
     1381 tagcgcccgg gtccagcggc agatagctgc cggaggcctt atcgtagatc ttcacattct
     1441 gcacacgcgg ggtaccggtg gcgctgccga tccagacgtt cttctcgtcg gtctgcacag
     1501 tgttggggat atcggtgtgg atctcgtagg tagcaccggc cacctgcagg aagccgccgt
     1561 tctccttgcc gtcctcgcct gcaaagcggg ctgcaaactc caatgcgtcc tggatctgct
     1621 tgccggtgac cgacatcagg caggccacgt tgccaaaggg gctgacctgc ttgcaggtct
     1681 tgaaggtcca gtcgcctgca ggcacatcgg cgcggatgcc gccgccgttc atgatggcca
     1741 catcacagtg cagcttttcc acctcgttga agtaggtgta gatgccgtca gccacaaagt
     1801 cgccgagatt ggtctcggca gagcggatgc ggcgcttgcc ggtggcgggg tcagagacgt
     1861 agaaatcgct gtcgcccaca gcgatcttct cgcccagcat atcgtccacg gtgttcaccc
     1921 agccagtctg catggcggcg atgcctgcgt ccatgccctc gtgggtggga atgagtttgg
     1981 tggtgatggt gccgtccgca gcgatggtca tctcgccaac gtttgcaaag taagagccgg
     2041 tctgggtcag ggtgacagcc ttgccggagg catcctgcac ctgcttgttc tccattacgg
     2101 tatgggagtg gccgtcgata aaggcgtcaa agccgctggt gtgggcaatg acttcctcac
     2161 tggtccacgg agaggaagag gggtctacgc ccagatggcc cagaccgatg accacatctg
     2221 ccagaagctt tgccttatca atggccttct gcacggcgtc atagagcttt ttgccgtcct
     2281 cgccgccctg aatatcgtag atgtacttgc gctgtgcctt atccataaag taggccgggg
     2341 tggacttggt aaaggtttcg ggggtggtca cgcccacaaa ggcaatgcgt ctgccgccgc
     2401 gcacgaacac cttgacggag ggcagcacac gcagcgtagt gcgcaggtct acccagttgc
     2461 aggacaggta cgggaagtcg gcttccttca tgatggcctt ggcacggtcc atgccgtagt
     2521 caaactcgtg gttgccgggg gtggcgacat cgtaaccggc agcgttcatc agcttgatga
     2581 tggaagcacc ctcgtccatg gagccgtagg cggtgccctg cacatggtcg cctgcatcca
     2641 ccagcagcac atccttgccg gcgttctgat agctctgctt caggtcggca atggcagcgt
     2701 aggtcagctt ggggctctgc ttgtcgatgt aggtatggac atcgttggtg tacaggatgg
     2761 taacgtcaga cttgtcacca taccagcagg ccgatgcggc aggcgcaccg atggccatgg
     2821 atgcagcggc agcggtcaca ccagcagcct ttaaaaagct gcgacgggaa ataagttgtt
     2881 tcacaggaaa acgacctcct tttatttttg gcgtatcgca tttgggcagg ctcttccctc
     2941 ctgccctttc aatagttcta gcatagcaca gaacgccgcc gcaaacaagc caaaatcatt
     3001 cttttggcac aaattatttt cacgttccgc tttattttaa catatattgt accattttta
     3061 cacaaatccc atgcaaaaaa gaccttcccg tgccctgtcg tagagcagcg gagaggtctt
     3121 ttttaggggg gtgttgaccc gttgccgggt ctatcggagg agagggaaat atcagatggc
     3181 gttatactcc ttgaggaact tctcaaggtc ggtgccctcg atcttcttca aagcttcctt
     3241 cagagccaga cgcgggatca gcggcagatc catgtcggtg atcttcttgc cgtcgcgcag
     3301 cttcacggtg gcatcgatca gagcgcgcac atcgtaggtg ctgccccaga cctcgggcac
     3361 gccgcggtca atgttcagca gggtgtacac agcctccata ccggtgcgca tggagtactc
     3421 ggtggtgaag atggtgtcgc gggcggtctc ggcaaactga ccgaggaagg caaagttcac
     3481 agcaccctcg ggcacaacat cgggacggtc gcccatggca cggggcatga agaaggcgtc
     3541 gatataaggc atcatcacag gcacggtgtt ggcactgtgc tctgccagtt ccgcgatctg
     3601 atcctcgggc acaccgatgt ggtacagcca ctccatgcag atctcgcggc cggtgcagtc
     3661 gcgcatgggc tttttgacat aatcgccggg cttatcgctg aacaggccgt acacccagac
     3721 gcacagctgg ttcttgggct gatccttgaa ctgctgctga cggttcagcg tccagctgag
     3781 cagccagctg gagtccttga cggtgacgat gccgccggtg acggtatggc cgctgaaggg
     3841 gtcgcgcttg cagatcttgc ggatatactg agggattttg tcgtccagcg tggtgatggt
     3901 ggcgctctcc cagttgctca gttccggctc agagcagaac ttctccgggt gaccgaagga
     3961 gggatcctgt gcggcgatct tcttccacag atcccagccg ttgccgggct ggatggtggg
     4021 gtcaaagccg gtggccttat cctgtgcacc cacggtgcag ctttccacgc agccgccgtt
     4081 ggtgatgaac agcagatcgt tctcggtcag gtcgatgtta gaagtctcgc ccgcgtgctc
     4141 cacggtgacg gagcttgcca gcttgcggcc cttctggatg tcgaacttca catccgtgac
     4201 cttggtgttg tagtggaact gcacgccgaa gccttccaga tagcgcacca tgggcaggat
     4261 gatggactcg tactggttat agcgggtaaa gcgcagggcg gtaaagtccg gcagaccgcc
     4321 gatgtggtgg atatagcgct tgaggtacag cttcatctcc agagcgctgt gccagttctc
     4381 gaaggcgaac atggtgcgcc agtacatcca gaagttggtg ttgagcacct cgtcatcaaa
     4441 gaaatcggtg atctttttat cctgcagctg ctcgtccggg gtaaagaaca gcttcatgat
     4501 ctccatggca cccttatcgg acaggccgaa tttgccatcg gtgtgagcat cctcgccgcg
     4561 gttgacggtg gcgcggcaca gggagaagtt ggggtcctcc ttgttcagcc agtaatactc
     4621 gtccagcacg ctggcaccct cggtctccag agaggggatg gagtgcagca gatcccacat
     4681 aacttcgaag tggttgtcca tctcgcggcc gccgcgcatc acatagccga tatcgtactt
     4741 gtagccatcg caggcaccgc cggccagtgc gttcttttca aacacatgga cgtgctcgcc
     4801 cttcatctgg ccgtcgcgca ccagatagca ggcagcggtc agggctgcca gaccggagcc
     4861 gatgatataa gcggatttat gatccacgcc ctccggcttt ttggggtgtg caaaagcttc
     4921 ataattgcca ctggaatagt acataaaaaa gcctccctgc ttccatattt tcgtttcaca
     4981 gccttcatcg tgctgttctc tatggcaaca gtataccccg caaagtgaac aggaacaaca
     5041 aacaaacttt gcccggtgta tagatttttt acatccgccc tcatttgctg gaaatgcgta
     5101 caaattgtga cataaagcgc agcgcaaaat catttaaaac actccctcaa aagtgcaatg
     5161 ccgggcagcc cgcaggctgc ccggcattgc actaatttaa aataattttc cgctattcat
     5221 gcccagagca tagcggcggg cattcaaaat cgtccccgcg caaaaagaga gccgccgcac
     5281 aaggttctgt gcagcggctc tccggtggat tttagttcat ctgttccaga gcctttttca
     5341 ggttctttgc aatctggtcc gggcagctgg tgctgcggaa gccgcacagc gtgccgtcca
     5401 gacgggcaat ggcatcctct gccttcatgc cggtaagcag ctggcagatg cccttcaggt
     5461 tgccgttgca gccgccgatg acctcgatgg aagaaatggt gtggtcatcg ttcagcacaa
     5521 agttggtctg cttggagcag gtacccttgt tcgggaagga aaattcctta ctcatggtct
     5581 ttacgtcctc tctcttttac gtttttcggc gatggcgcgc agctgcgctg cggcttcgtc
     5641 cggtgcggtg caggtgccga tggggtgggg gtgcttgtgg ttgcggccat ggaagtccgt
     5701 acctgcggtc gccacaaggc cgtactgttt gcacagggca aggcactcgg cgctgtcctc
     5761 cgggctgtta ctgggatggt acacttctat gccgtccact gcgccctctg ccgccagctc
     5821 gcgcagcagg ggcatacttt tatacaccgt ggggtgggca aacaccaccg cgccgccgct
     5881 tgccttggcg gtagccagca cctgccgcac cggcagatac tccggcgaat gcagcacgat
     5941 accccggggg ttccacccga acagcttgtg gtaggtctcg ccgtagatgc tgccatcggt
     6001 cagacccagc agttccagtg cctgcatcag cccgcttttg aacagcaccc cgctggcctt
     6061 tgtggtctcc catgcaaggt cggtggtaaa ctgcgggtac agctgctcca gttcctttgc
     6121 gctctgcaaa gcgcaggcgt tgcggcgctc cttcataatg gcgcagtgct cccgcagcgc
     6181 cgggcagtca acatccgggt agtagcacag caggtgcacc cggtgctggc gctcaaagtc
     6241 gtagccggtc agctccacgg cggggatcag ctctaccccg tcctgcccgg tgtgggcata
     6301 ggcgtactga gcgctgagca gggtgtcgtg gtccgaaagg gcgatggcgt gcagcccggt
     6361 gcgggcagcg atgggtgcca gccgctcaat gggcacagca ccgtcggagc aggtggaatg
     6421 gatatgcagg tcacaggaca tagcgggtta cttccttagt gcttatagaa attgatcagg
     6481 cagccgtcgg ccaggatctg gcgctcgtcg gtggtgagcg gagccatgta cagctcaaac
     6541 tccttgacgg tatcgcccag aacataggcc ttgatgttct gcaggtcgcc cttgagtgct
     6601 tcccgcacat tggggatgag cacatagtcc cccagaccaa agggggtggc gcctgccagc
     6661 tgcaggggca gcatgcccca gttgatcagg ttggagcggt aacgcttggt agcgtactcg
     6721 gtaacgatat tggcaccggc acccagcaca cgctggcagc tggcggcctg ctcgcgggca
     6781 gagccgtcgc cgggcttgac cgcaaagatg gtagaggcga tctggatatc gttccagctc
     6841 agcttctcgc agccgggcac ggcgttcacc tttgccagca gagcagcgtc ccctgcaccg
     6901 gcgcggcggg cgttctcttc ggcctgcaca gccttggcgc ggcccacata ctccgggtcc
     6961 ttgcggctga gggtgaactc agccagaccc agcggattgg aacggtaaga ggacgtctcg
     7021 ccggagggga tcagctcatc ggtggtggtg acggggtcgg tgatataaga agccaccttc
     7081 agcagcaggt tgtcgcccag cggtgcgatc tccggccagt ccttgatgtt ggggccaaac
     7141 ttgagcaggg catcgtaatc gcccttgcca aagccctgat agacgcgggt gtcgtagctg
     7201 gaagcatcgt actggtactc cggcacggtg ggatcgtaat caatgtcggt ggcgggggtc
     7261 aggatgccgc cgtttgcggt ggtggctgca atgctacggg catccatcag tgccacaccg
     7321 gccagctggc cgctgccggg cttggagccc tcgcggctgg ggaagttgcg ggtggtgtga
     7381 cggatggaca gtgcaccgtt ggcgggcaca tcgcctgcgc cgaagcaggg gccgcagaag
     7441 gcggtgcgga tggtagcgcc gctggccatc aactcgccga tgacgccggt gcgcaccagt
     7501 tccatcatga tgggctgact gccggggtaa acgctcaggg cgtagtcgcc gcaaccgccg
     7561 gtatgaccct tgaggatgga agcagcctcg taaatgctgt cgtacagacc gcctgcgcag
     7621 cctgcaatga cgccctgatc cacacgcagc ttgccgtttt cgatcttgct gcacagatcc
     7681 agctgcacat ccttgcggcc gatcagcttc tgcacatcct gttcgcaggc gtggaggatg
     7741 tcctccagat ttgcgttcag ttcttcgatg gtaaaggcgt tggaggggtg cataggcagg
     7801 gcgatcatgg gacggatggc agaaagatcc acctccacca caccatcgta gtaggcaagg
     7861 tctgccggtg caagtttttt atagtctgct gcacggccat gcactgccag aaaacgctgg
     7921 gtgacttcgt cggtctccca gatggaggac agacaggtgg tctcggtggt catggcatca
     7981 atggcgttgc gggtatcctg ccgcagggaa gcaatgccgg ggcccacgaa ctccataacc
     8041 ttgtttttga cgtagccgct cttgaacagc ttgcccacaa gggcaatggc tacatcgtgg
     8101 gggccgcagc ccaccggcag actgccggtc aggtagatgg ccaccacacc cgggcgggca
     8161 acatcatagg tgcggcccag cagctgcttt gccagctcgc caccgccctc gccgatagcc
     8221 atggtgccca gtgcgccgta gcgtgtgtgg gagtccgagc caaggatcat tttgccgcag
     8281 ccggcaaagc gctcgcgcat atactggtgg atgactgcca tgtgcggggg cacaaagata
     8341 ccgccgtact ttttggcagc ggacaggcca aagcggtggt cgtcctcgtt gatggtgccg
     8401 cccacagcgc acaggctgtt gtggcagttg gtaagcacat aaggaatggg gaacttttcc
     8461 agcccggaag cacgggcggt ctggatgatg cccacaaagg tgatgtcatg gcttgccatg
     8521 gcatcaaact tgatcttcag gttctcggca tcgccgctgg tgttgtgtgc ctgcataata
     8581 ttgtaggcca tggtaccggt cttagccgcg gcaacggcag cggcatcaaa gccctttgct
     8641 gccagtgctg cgggtgcatt gccatctgcg ggcacccact ctccgcgcgc ataatacgca
     8701 ccgccggtgc tgcatttgat catatccaac atctcgattc gcctctcttt ttgtattttc
     8761 ccgcccgccg caattgcggg cattgccccg gcagtgcggc tattcatccc gaaaacagcc
     8821 gttcccttag ccttcacccc ttggggggaa gccattaagc aaaccagctt ttcaaagact
     8881 tataacccct gccctgttac ggcaaagccg tatttatttg ttattatagc atgaaaaggc
     8941 gaaaagaaaa agcatttttt atgaaccctt actgcacctt tgcggcggct tcctgctgct
     9001 tttccttttg cagtttacgg aacaccacaa aataggccgg gatcaggaag aagcaggcaa
     9061 agagccatgc caccgggctt gcgatgcagg cggcaaagta gccccacagc ggcacgaacc
     9121 agaagcccac catggcgcgg gcgatcatct cagccacacc ggcaaacatg gcaaggccgg
     9181 agtgccccag accctgaatg gtgtagcggt agatgataag cactgccagc gggatgtaga
     9241 acacactgtt ccagaagatg aagtcctgcg cattggccat aatggcggtc tcgcctgcgt
     9301 ccaggaacag gccgatcagg ggcttgtcca gcacgcgcag gatgaggaag gaggccacgc
     9361 tgtacacgca gccgatgccc agtgcggtgt tcacgccgcg gttcacgcgg cccagatcct
     9421 tcgcgcccat attctggctg gtgtaggtgg tcatggcggt gccgatgctc tccagcggca
     9481 cgctgaggaa ctgcgcagcc ttgccgccgg cggtctgcgc ggctacgata tcgctgccca
     9541 gaccgttcac cgcgccctgc agcaccacgc tgccgatggc agtaatactg cactgcagac
     9601 ccatggggag gcccatggcg caaagctttg cgcagtgcgg agcgctgatg cgcccttctt
     9661 ccttattcca gcgcagttcc gggtagtggc gcatgatgta aataaggctg ccgatgcccg
     9721 ccacagcctg actgaacacg gtggcaaagg ccgcgccgaa cacgcccatg ttgaacagga
     9781 tgatgcaggc aaggtccagc ccgatgttca gcacgctggc caccagcagg aaatacagcg
     9841 ggcgcttgct gtcgcccagt gcacgcatca gggcgctggt cacattataa agcagcgtga
     9901 aggggatgcc tgcaaaaatg gtgcggatat agatatccgc aaggtcgatg atatcggccg
     9961 gggtgttcgt ccacaccagc accagatggg tcattgccac cgtaacgatg gtaagcaccg
    10021 tggcaaaagc gatggacagc cacacggtat tggcggtgta gcggcgcatc tcgtggtggt
    10081 cgtgggcacc gaaggtccat gagatgggga tggaaaagcc gcaggcaatg ccgttgacaa
    10141 agcccagcac cagatagttc aggccgccca cgctgcctac cgctgccagc gcttccacgc
    10201 ccacgaaccg ccccacgatg atggtatcgg ccagattgta gaactgctgg aacaggctgc
    10261 ccagcatcag cggcacagc
//
