LOCUS       c00452_gnlPro..        12662 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JFIKLNHI_452.
ACCESSION   c00452_gnlPro..
VERSION     c00452_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 06:25:58
            Original ID  :: gnl|Prokka|JFIKLNHI_452
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12662
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12662
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3112:7355]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3113..7355
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..12662
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12662
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             2..508
                     /locus_tag="ctg452_1"
                     /transl_table=11
                     /translation="VYLAKKYENSGVPAEDLVSIGTIGLIKAVNTFTPARSIKLATYAS
                     RCIGNEILMYLRKSSNRRQEASIDEPLNVDGDGNELLLSDILGSDANAVSQQLEQDAER
                     AVLRSAVAALSARERQIMELRFGLTDGVERTQKEAADALGISQSYISRLEKRIIRTLKA
                     RLESE"
     CDS             666..1433
                     /locus_tag="ctg452_2"
                     /transl_table=11
                     /translation="MYNKVELCGVNTGQLPVLTEAEKRQLLTLAHAGDKAARARMVEGN
                     LRLVLSVVQRFAQRGENLDDLFQVGCIGLIKAIDNFDPAQPVRFSTYGVPMIIGEIRRF
                     LRDNNALRVSRTLRDTAYRAMQARETLEKQLGREPTMDEIAAAAGLARREVTAALESVV
                     EPLSLDEPVYTDGGDAMYVIDQVRDPDSEESWISGLQFRDTVAALSPREKRIMELRYLR
                     GKTQMEVAQEIGISQAQVSRLEKGALQQFHTGG"
     CDS             complement(1501..1749)
                     /locus_tag="ctg452_3"
                     /transl_table=11
                     /translation="MKADPEQRAVQLGEYIAAHNATVRAAAAAFGCSKSTVHKDVAVRL
                     RSISPALYGQVRAVLARNKAERHLRGGAATRRRYSRR"
     CDS             2046..2612
                     /locus_tag="ctg452_4"
                     /transl_table=11
                     /translation="MSKTYSKTRILVECALMIAIGTVLSNIKFFTMPNGGSITLLSMLP
                     FVLVSFRHGAKWGLFTGFVNACLQMIMGFYPPPASTFLYFLGEVLLDYVLAFMALGLAE
                     LFARPFKNRTVGVAVGTFAAGFLRFMCSFLSGVLVWGNLNDGLAAWTYSLTYNGSYMLP
                     ETLLTMVAAVLLCRVAPQIFDRQAR"
     CDS             complement(3113..4324)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg452_5"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 7.9e-15,
                     bitscore: 44.8, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVRDSRPPFAGLANLSEAQLHRLPTPCYLLDEAQLCRNGEILLG
                     VQQRTGCRILLAQKAFSNFNVYPVLAPYLAGTEASGLYESRLGREELPEKENHVFCAAY
                     RADEFEELLQYADHIVFNSPSQLAKFGPAAKAAGKSIGLRINPECSTQEGHEIYDPCAP
                     GSRLGTTRAQWDAAVAAHPELPALLDGLHFHTLCEQDADALAVTLAAVEKKFADLLPRM
                     QWLNFGGGHHITRPGYALATLESCILSVRQKYGVQVYLEPGEAWALNAGYLVTTVLDTL
                     RNGDTSLAILDMSAACHTPDVIEMPYRPPLLDAGEAGEKAHTVRLGGPTCLAGDIIGDY
                     SFDAPLAEGDKLIFGDMAIYTTCKNNTFNGMPLPPIWLLGADGNCRELVHFGYQDFKMR
                     LGAQ"
     CDS             complement(4324..5583)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg452_6"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 3.6e-45, bitscore:
                     144.9, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 1.6e-33,
                     bitscore: 105.6, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKVLIIGCGGVASVAIHKCCQVPEVFTEICIASRTKAKCDKLAA
                     ELAPTTATKITTAQVDADKVEEVIALIKAYQPDLVMNIALPYQDLTIMDACLACGVNYM
                     DTANYEPENTDDPEWRAIYEKRCKEAGFSAYFDYSWQWAYAKKFEEAGLTALLGSGFDP
                     GVTQAYCAYAKKHEFDTIDTIDILDCNGGDHGYAFATNFNPEINLREVSAPGSYWENGH
                     WVEIPAMSIKREYNFDQVGDKDMYLLHHEEIESLAKNIPEAKRIRFFMTFGQSYLDHMR
                     CLEDVGMLSTTPVNFNGQEIVPIQFLKALLPDPASLGPRTKGKTNIGCIFTGKKDGKDK
                     TYYIYNVCDHQECYKEVGSQAISYTTGVPAMCGALMLLTGKWTTKGVHTVEEFDPDPYL
                     DALDKYGLPRSESHNPALVD"
     CDS             complement(5623..6498)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Arginase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg452_7"
                     /sec_met_domain="Arginase (E-value: 3.5e-77, bitscore:
                     249.3, seeds: 235, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHPNVETFIGCDSSYRAASIVLYGAPYDSTTSYRPGARFGPAAIR
                     HESYGLETYSPYQNADLTDFDVFDSGDLELCFGSSELALADIEARAEEILKDGKFPLLL
                     GGEHLVTLGAVRAAVKKYPDLHIVHFDAHADLRDDYLGAKLSHACVLRRCHELVGDGHI
                     HQFCIRSGDRAEFEFAAQHTEMHKFDFTGLAELTAQLCESKVPVYLTIDLDCLDPSCFP
                     GTGTPEAGGVSFLQLLGAIRTVTKANIIGADLNELAPTLDTTGVSTATACKVLRETLIA
                     LDKGWPGFQV"
     CDS             complement(6498..7355)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg452_8"
                     /sec_met_domain="Spermine_synth (E-value: 3e-54, bitscore:
                     173.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 3.1e-23,
                     bitscore: 71.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFWFSEFHTPDVKHSIRVNKQLYSKQSDYQRIDIFETPEFGRVL
                     TLDGNVMLTERDEFIYDEMIVHVPMAVHKEAKDILVIGAGDGGVVRELTRYDRVERIDL
                     VEMDPQVVEACRAYLPGNACRMDDRRVHIYFENALKYIRRCEEEYDLIIVDSSDPFGPS
                     EGLFTREFYGSCFNALKEDGIMVNQQGSPFYAEDASAMQRSHKRIASTFPISRVYQAHI
                     PTFAAGYWLFGFASKKYHPIDDLDAEAWKALNMRTRYYTTKLHIGAFYLPAFLEEMLRE
                     VEEH"
     CDS             complement(7368..8834)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg452_9"
                     /sec_met_domain="OKR_DC_1_C (E-value: 4.3e-12, bitscore:
                     36.3, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 1.7e-123,
                     bitscore: 401.9, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNENKARSRLDQRRAPIYEALERFRQMRVVPFDVPGHKRGRGNPE
                     LTAFLGQQCVGVDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSSVQS
                     MVLTACKRGDEIILPRNVHRSVLNALVLCGAVPVYVNPEVDKRLGISLGMKREQVAKAI
                     KEHPNAVAVLVNNPTYYGICSDLRAIVKMAHDAGMLCLADEAHGTHFYFGGGLPVSAMA
                     AGADMASVSMHKSGGSLTQSSLLLIGPNVHQGYVRQIINLTQTTSGSYLLMSSLDISRR
                     NLALRGRQVFHQVADIAEYAREEINAVGGYYAFGKELCNGDSVFDFDTTKLSVHTLDIG
                     LAGIEVYDILRDEYDIQIEFGDIGNILAYLSIGDRPQEVERLVSALAEIKRRYRTDGSG
                     LLSQEYIDPVVAASPQEAFYAPKKSLPLRETEGMVCSEFVMCYPPGIPILAPGERITKE
                     ILNYIEYAKAKGCSMTGPEDPEILHLNVLA"
     CDS             9427..10149
                     /locus_tag="ctg452_10"
                     /transl_table=11
                     /translation="MALPIAIVEDQAADARRLEELLQQQLPEAECTWFTCGDDFLRAAA
                     EPGLYAVVFLDICMAGTNGIETARRLRQADPEVLIVFVTSSPEYVWDAFPVHPFDYLLK
                     PYQEEKFVHLAAELRRALRCKEPELEIRIARQSIQLPLRKVLYAIARNHYVLITTEDGE
                     YRAICSFAQIEEKLTALENFMSCNRGVIINMDKVLRFGEDCIEILDGTRLPVRQKDKCT
                     LLAHFTQYQFRHMRQELH"
     CDS             10167..11483
                     /locus_tag="ctg452_11"
                     /transl_table=11
                     /translation="MDLALFGRYFLDFALLYPSAFLCLASLWEKLRTPKRTACIAAGCI
                     TLLCIGCAALCAVFGLSSNSLLPAIVLVSFWLLRWRVTPEVTVSQTAFLFSISAVMMAV
                     CSLLSTLLNAQTEISNPQTVCLASTALLRLGLAAMLTVLFWFTAVQWSRWLLREYSGEA
                     FWQSAWPLPALYAVFLVYCMPLNPAVVLVGRLKIISVLAVSISLFGIFLLLYEMYRVAR
                     EFARNARLDRENQLLAMESRRYMELQTYLDNTRRLRHDFRQHLHVIAGLTETGQLEELK
                     SYLHQYESELSEHRPSLCANAAVDALAGYYDHAAGQQSVPVEWKLALPRQLPMPEADLC
                     TILGNLLENALHASQKLPPEQRRVQVMAQMLSPAMLGLVVENRYDGMLKKQQGILRSTK
                     HEGTGIGLVSAETVVHKYNGNLHLETEEQIFRVNVLLNL"
     CDS             complement(11570..11809)
                     /locus_tag="ctg452_12"
                     /transl_table=11
                     /translation="MGFFAVLAASLFAVFIFTVFGGYSLLLWCQQSLWMVVPPALVLAV
                     LVWTFLKMDDKITALQKRVDELEAAQKSTEKLEK"
     CDS             complement(11829..12305)
                     /locus_tag="ctg452_13"
                     /transl_table=11
                     /translation="MIYDTLNNLPNYLGVSDNLDTVIEYIMARDITTLPAGRTRIDGDK
                     AVVTVSTVTPQTSDKALFQRHDNHITLETDLDGSELFEVSLAELTPTKPTDEAADTTVG
                     TAGTSIAGMLCEGRFALYLAGEPYKSGLKAQGCGKLKKAVFSIELDPDEEETEE"
ORIGIN
        1 agtgtatctg gccaaaaagt acgagaacag cggtgtgccc gccgaggact tggtaagcat
       61 tggcaccatc gggctgatca aggcggtaaa caccttcacc cctgcccgca gcatcaagct
      121 ggccacctac gccagccgct gcatcggcaa cgagatcctg atgtacctgc gcaaaagctc
      181 caaccgccgg caggaggcca gcatcgacga gcctttgaac gtggacggcg atggcaacga
      241 gctgctgctc tcggacatcc ttggcagcga tgccaacgcg gtaagccagc agctggagca
      301 ggacgccgag cgcgcggtgc tgcgcagcgc cgtagcggcg ctctcggcac gggagcggca
      361 gatcatggaa ctgcgtttcg gccttaccga cggcgtggag cgcacccaga aggaagccgc
      421 cgatgccctt ggcatcagcc agagttacat ctcccggctg gaaaagcgca tcatccgcac
      481 cctgaaagcc cgccttgaaa gcgagtagca gcgggcgcag cgcttgacat tccgcgtggg
      541 aacgtgtatc aggtttgtct ataatgcgcc cctcttttgc ggaggggcgc tcaatttttt
      601 ccacgcatag cgcccggcgc gcagagccat acttccggta aagctaaaag accgggggcg
      661 tttggatgta caacaaggtg gagctatgcg gtgtgaacac agggcagctg cctgtactga
      721 ccgaggcgga aaagcggcag ctgctcaccc ttgcccacgc cggggacaaa gctgcccggg
      781 cgcggatggt ggagggcaac ctgcggctgg tgctcagtgt agtgcagcgg tttgcccagc
      841 ggggcgaaaa tctggacgat ctgtttcagg tggggtgcat cgggctgatc aaggccatcg
      901 acaactttga ccccgcgcag ccggtgcggt tttctaccta cggcgtgcct atgatcatcg
      961 gggagattcg gcggtttctg cgggacaaca acgccctgcg ggtaagccgc accctgcggg
     1021 acaccgccta ccgcgccatg caggcgcggg aaacgctgga aaagcagctg gggcgcgagc
     1081 ccaccatgga cgagatcgcc gctgcagcgg ggcttgcccg gcgcgaggtg accgccgcgc
     1141 tggaatcggt ggtggagccg ctcagccttg acgagccggt gtacaccgat ggcggcgatg
     1201 ccatgtatgt gatcgaccag gtgcgggacc cggacagcga ggagagctgg atcagcgggt
     1261 tgcagttccg cgatacggta gccgctcttt cgccccggga aaagcgcatc atggagctgc
     1321 ggtatctgcg cggcaagacc cagatggagg tggcgcagga gatcggcatc agtcaggcgc
     1381 aggtaagccg gctggaaaaa ggcgcgttgc agcagttcca caccggggga tgaaggcagc
     1441 cgcctgaaaa ccctctcagc aaaaaagacc gctgcgcagt gcagcggtct tttttgggct
     1501 tcagcggcgg ctgtatctgc gccgggtggc agccccgccc cgcaggtggc gctcggcctt
     1561 gttgcgggcc agcacggcgc gcacctgccc gtacagcgcc gggctgatgc tgcgcagccg
     1621 cacggcaacg tccttgtgca cggtggactt gctgcacccg aacgcagccg ccgctgcccg
     1681 caccgtggcg ttgtgggcgg caatgtactc ccccagctgc acggcgcgct gttccggatc
     1741 ggctttcata tcccgcctcc ctgcgttcca gctttgcaat ggtataacat acgcgccgcc
     1801 ggggcggatt atgtctgcgg acttgacttt ttgtcccacg gcgcgtatac tgtgggcgga
     1861 cataaaaaca ggggcgccgt aaggctgaga tccgcatagc gcggagtacc ctttacctga
     1921 tccgggcaat gccggcgtag ggagtttgcg gaaccgtccg gtacgttcaa caaacctcca
     1981 tgcgtctgct gccagcagac gcattttgtt tttatgtact actatgagag aggaattttt
     2041 ccatcatgtc taaaacctat tccaagaccc gcattctggt ggaatgcgcc ctgatgatcg
     2101 ctattggcac ggtgctttcc aacatcaagt tcttcaccat gcccaacggc ggcagcatta
     2161 ccctgctgag tatgctgccc tttgtgctgg tgtccttccg ccacggcgca aagtggggac
     2221 tattcaccgg ctttgtaaac gcctgcctgc aaatgatcat gggcttctac cctcctcccg
     2281 cttccacctt cctctacttc ctcggtgagg tgctgctgga ctatgtgctg gcctttatgg
     2341 cactgggtct ggccgagttg ttcgcccgcc ccttcaagaa ccgcaccgtg ggtgtggctg
     2401 tgggcacttt tgccgccggt ttcctgcgct ttatgtgcag ctttttgtcc ggtgtgctgg
     2461 tgtggggcaa cctgaacgat ggtctggccg catggactta cagcctgacc tacaacggca
     2521 gttatatgct gcccgagacc ctgctcacca tggtagccgc tgtgctgctg tgccgtgtgg
     2581 ctccgcagat cttcgaccgt caggcacgct aaggcgtagt ttttcccaaa agagcactcc
     2641 cccacttttt cgatccccgc cgggcacacg ccctgcgggg atctttgctg caaaaaattt
     2701 gcaaaaaact gttgacaagt gcccctccgg ctggtataat tacacacgtc gtcagacaca
     2761 aagcaagaca tctgggggtt tagctcagct gggagagcgc ttgcatggca tgcaagaggt
     2821 caccggttcg atcccggtaa tctccaccag aaatgaaagc actacacaga aatgtgtggt
     2881 gcttttttgt tgacgccaaa cgagtgaggg tttagctcag ctgggagagc gccgtgcatg
     2941 gactgcaaga gggtcaccgt gatttgaatc ggcccggtaa tctccaccag aagcgaaagc
     3001 actacacaga aatgtgtggt gcttttttgt tttatctgcc gttcacctta cgtccccttt
     3061 catgaaaaaa gcgtttgtcg cagcccgcag gccgtgacaa acgcttttta ttttactgtg
     3121 cgcccagacg cattttgaag tcctgatagc caaagtgcac cagttccctg caattgccgt
     3181 ctgcgcccag cagccagatg ggcggcaggg gcatcccatt gaaggtgttg ttcttgcagg
     3241 tggtgtagat ggccatatcg ccgaagatga gcttatcgcc ctcggcaagg ggggcgtcaa
     3301 agctgtaatc cccgatgata tcccccgcaa ggcaggtggg gccgcccaag cggacagtgt
     3361 gcgccttctc ccctgcctca ccggcatcca acagcggcgg gcggtagggc atctcgatga
     3421 catccggggt gtggcaggct gcggacatat ccagaatggc aagactggta tccccgttgc
     3481 gcagggtgtc cagcacggtg gtgacgagat atcccgcgtt cagcgcccaa gcctcgccgg
     3541 gctccagata cacctgtacg ccgtacttct gccgcaccga gaggatgcag ctttccagcg
     3601 tagcaagggc atagcccggg cgggtgatat ggtgcccccc gccgaagttg agccactgca
     3661 ttctgggcag caggtcggca aactttttct ccactgcggc cagcgttacc gccagcgcat
     3721 cggcgtcctg ctcgcagagg gtatggaagt gcagaccgtc cagcagggcg ggcagctccg
     3781 ggtgcgccgc cacagcggcg tcccactgag cacgggtggt gcccagacgg ctgccgggtg
     3841 cgcaggggtc gtaaatttcg tgcccctcct gcgtggagca ctccgggttg atgcgcagac
     3901 cgatgctttt gcccgccgcc tttgccgccg ggccgaactt tgccagctgg ctgggcgagt
     3961 tgaacacgat gtggtcggcg tattgcagca attcctcaaa ctcatctgcc cggtaggcgg
     4021 cgcagaatac atggttctcc ttctccggca gttcttccct gcccaagcga ctctcgtaca
     4081 ggccgctggc ctcggtacct gccagatagg gtgccagcac cgggtagacg ttaaagttgg
     4141 aaaaagcctt ctgcgccagc agaatgcggc agccggtgcg ctgctgcaca cccagcagga
     4201 tctcaccgtt gcggcacagt tgggcttcgt ccagcagata gcagggggtg ggcaggcggt
     4261 gcagctgcgc ctcggacagg tttgccagcc ccgcaaaggg cgggcggctg tcgcgcaccc
     4321 gcatcagtcc accagagccg ggttatggct ctcggagcgg ggcaggccgt acttatccag
     4381 tgcatccaga tacggatcgg gatcaaactc ctcgacagtg tgcacgccct tggtggtcca
     4441 cttgccggtg agcagcatca gtgcaccaca catggcgggc acgccggtgg tgtagctgat
     4501 ggcctgactg cccacttctt tgtagcactc ctgatggtcg cagacgttat agatgtagta
     4561 ggtcttatcc ttaccgtcct ttttgccggt aaagatgcaa ccgatgttgg tcttgccctt
     4621 ggtacggggg ccaaggctgg cggggtccgg cagcagtgcc ttgaggaact ggatgggcac
     4681 gatctcctgt ccgttgaagt tgacaggggt ggtggacagc atgcccacgt cctccagaca
     4741 gcgcatgtga tccagataac tctggccgaa ggtcatgaag aagcggatgc gctttgcctc
     4801 cgggatgttc tttgccagag actcgatctc ctcgtggtgc agcagataca tatccttgtc
     4861 acccacctga tcgaagttgt actcccgctt gatgctcata gcggggatct ccacccagtg
     4921 gccgttctcc cagtagctgc cgggtgcgga cacctcgcgc aggttgatct cggggttgaa
     4981 gttggtggca aaggcatagc cgtggtcgcc gccgttgcag tccagaatgt cgatggtgtc
     5041 aatggtatca aactcatgct tttttgcgta ggcgcagtat gcctgggtca cacccgggtc
     5101 gaagccgctg cccagcaggg cggtcagacc ggcttcctcg aactttttgg cgtaggccca
     5161 ctgccagctg taatcaaagt aggcagagaa gccggcctcc ttgcagcgct tctcgtagat
     5221 ggcgcgccac tccgggtcgt cggtgttctc gggctcgtag ttggcggtgt ccatgtagtt
     5281 gacgccgcag gcaaggcagg cgtccatgat ggtcagatcc tgataaggca gggcgatgtt
     5341 catcacgagg tcgggctggt aggccttgat gagggcgatg acctcctcca ccttgtctgc
     5401 gtccacctgt gcggtggtga tcttggtggc ggtggtggga gccagctcag cagccagctt
     5461 atcgcacttt gccttggtac ggctggcgat gcagatctcg gtgaacacct cgggcacctg
     5521 gcagcactta tggatggcaa cggaggccac gccgccgcag ccgatgatca gaactttgct
     5581 catgtcggtt actcctttat ctgtaaaatg gtaggttcgt atttatacct gaaagcccgg
     5641 ccagccctta tccagcgcga tcagggtctc gcgcagtacc ttgcaggcgg tggcggtgga
     5701 aacgccggtg gtgtccagcg tgggggccag ctcgttcagg tctgcgccga tgatgttggc
     5761 cttggtcaca gtgcggatgg cacccagcag ctgcaaaaag cttacgccgc cagcttccgg
     5821 ggtaccggta cccgggaagc aggaggggtc aaggcagtcc agatcgatgg tcagatacac
     5881 cggcaccttg ctctcgcaca gctgtgcggt cagttcggca aggccggtaa aatcaaactt
     5941 gtgcatctcg gtgtgctggg cagcgaactc gaattctgcc cggtcgccgc tgcggatgca
     6001 gaactgatgg atgtggccat cccctaccag ctcgtggcag cggcgcagca cacaagcgtg
     6061 gctgagcttc gcgcccagat agtcgtcccg caggtcggcg tgggcgtcga aatggacgat
     6121 gtgcaggtcg gggtatttct tcaccgcagc acgcaccgca cccagcgtga ccaaatgctc
     6181 gccacccagc agcagcggga acttgccgtc cttcaggatc tcctctgccc gggcctcgat
     6241 atcggccagt gccaactcgc tggagccaaa gcacagctcc agatcgccgc tgtcgaacac
     6301 atcaaaatcg gtcaggtcgg cgttctggta ggggctgtaa gtctccagac catagctctc
     6361 gtgccggatg gccgccgggc cgaaccgtgc accggggcgg tagctggtgg tggaatcgta
     6421 aggcgcaccg tacagcacga tgctggcggc gcggtagctg ctgtcgcagc cgataaaggt
     6481 ctcaacgttg gggtgcatca gtgttcctcc acttcccgca gcatctcctc cagaaaagcc
     6541 ggcaggtaga atgctccgat atgcagtttg gtggtatagt agcgggtgcg catattcagt
     6601 gccttccacg cttctgcgtc cagatcatca atgggatgat attttttgct tgcaaagccg
     6661 aacagccagt accctgccgc aaaggtaggg atatgcgcct gatacacacg gctgatgggg
     6721 aaggtggatg caatgcgctt gtggctgcgc tgcatggcac tggcatcttc ggcgtagaag
     6781 gggctgccct gctggttgac catgatgcca tcctctttca gggcgttgaa gcagctgccg
     6841 tagaactcgc gggtgaacag accctcggag gggccgaagg ggtcggagga gtccacaatg
     6901 atgaggtcgt actcctcctc gcagcggcgg atatacttca gggcattctc aaaatagata
     6961 tgcacccggc ggtcatccat acggcaggca ttgccgggca ggtaagcgcg gcaggcctcc
     7021 accacctgcg ggtccatctc cacaaggtcg atgcgctcca cacggtcgta gcgggtcagc
     7081 tcccgcacca cgccgccgtc tccggcaccg atgaccagaa tatccttggc ctccttatgc
     7141 accgccatgg gcacatggac gatcatttca tcgtagatga actcgtcgcg ctcggtcagc
     7201 atcacgttgc cgtccagcgt gagcacccgg ccgaactccg gggtctcaaa gatatcaatg
     7261 cgctgataat cgctctgctt ggagtagagc tgcttgttta cacgaatgct gtgcttcaca
     7321 tccggggtgt gaaactctga aaaccaaaat tccatctctt tccctcctta tgccagaaca
     7381 ttcaggtgca agatttcggg gtcctccggg ccagtcatgc tgcagccctt ggccttggcg
     7441 tactcgatgt agttcaagat ctccttggtg atgcgctcgc cgggtgccag aatggggatg
     7501 cccggcgggt agcacatgac gaactcgctg cacaccatgc cctcggtctc ccgcaggggc
     7561 aggctctttt tgggggcgta gaaagcctcc tgcgggctgg ccgccaccac ggggtcgatg
     7621 tattcctggc tcagcagacc agaaccgtcg gtgcggtagc ggcgcttgat ctcggccagt
     7681 gcactgacca gacgctccac ctcctgcgga cggtcgccga tggacaggta ggcaaggatg
     7741 ttgccgatat cgccgaactc gatctgaata tcgtactcat cccgcaggat atcgtagacc
     7801 tcgatgcctg caagaccgat atccagcgta tggacgctga gcttggtagt gtcgaaatca
     7861 aagacggaat cgccgttgca cagttccttg ccaaaggcgt agtagccgcc tacggcgttg
     7921 atctcctcgc gggcatactc ggcaatatcc gccacctgat ggaacacctg ccgtccccgc
     7981 agcgccagat tgcggcggga gatatccaga ctggacatca gcaggtaact gccggaggta
     8041 gtctgggtca ggttgatgat ctgacgcaca tagccctgat gcacgttggg accgatgagc
     8101 agcaggctgg actgggtcag gctgccgccg ctcttgtgca tggacaccga ggccatatct
     8161 gcgcccgccg ccatggcaga aaccggcagg ccgccgccaa agtagaagtg ggtgccgtgg
     8221 gcttcatccg caaggcagag catcccggcg tcgtgcgcca tttttacgat ggcacgcagg
     8281 tcggagcaga tgccgtagta ggtggggtta ttcaccagca cagccacagc gttggggtgc
     8341 tccttgatgg ccttggccac ctgctcccgc ttcatgccca gcgagatgcc caggcgctta
     8401 tccacctccg ggttcacata caccggcaca gcgccgcaca gcaccagcgc gttcagcacg
     8461 ctgcggtgca cattgcgggg cagaatgatt tcatcgcccc gcttacaggc ggtaagtacc
     8521 atgctctgca cgctgctggt ggtgccgccc accattaaaa aggcgtgtgc tgcgccaaag
     8581 gcatcggcgg caagctcctc ggcttcccgg atgactgaca ccgggtggca aaggttatcc
     8641 agcggcttca tgctgttcac gtccacgccc acgcactgct gacccagaaa agcggtcagc
     8701 tccgggttgc cgcggccccg cttgtggccg ggcacatcaa agggcaccac ccgcatctgc
     8761 cggaaccgct ccagcgcctc gtaaatgggc gcacggcgct gatccagccg ggaacgcgct
     8821 ttgttctcgt tcatcttttc ctccgtccct gttcttcttt ttgcacaaca aaaaagcgca
     8881 ggcactgcac aaatatgcag acctgcgctt ggaaaagctt tttccgcgct gataaagcac
     8941 ccagccgtaa gtgccggtgc tgcgcgttat tcgcgatcca aaaagacggg gtgatgagag
     9001 tctatatagc aactacactt ttactactct tattgaccgt ttcacaagtc tgcgcatagg
     9061 ctgcgcaatt tcatggttgt aaaggaacca acttataaaa tttgagcttc aaactcaatc
     9121 aataatggca gcttgcgccg ccggtcggca gtggacccgg ctgtccgtat ggccttagcc
     9181 ccgtttgggc ggtcccgagt aaattgcttt gaaaagactc tgcaaggcgg cgtctctcaa
     9241 aatcaacaaa agaataacat gattcgcccc gtctgtcaac caaaactttt tggcagtcgc
     9301 ccgatgcggg tgtgcagggc ggcgctcggc gcgcaaaatg gagcgttttg tgcaaaaaag
     9361 cagatgccct tcccgccgca gtatgctata ataaaggaac aatgaatgga gaaagagggt
     9421 gtatggatgg cactgccaat cgccatcgta gaggaccagg cagcagatgc ccggcggctg
     9481 gaggagttgc tgcaacagca gctgcccgaa gccgagtgca catggtttac ctgcggagat
     9541 gattttctcc gtgccgcagc agagcccggc ttatacgccg tggtgtttct ggatatctgc
     9601 atggcgggca ccaacggcat cgagaccgcc cgccgactgc ggcaggccga cccggaggtg
     9661 ctgatcgtat tcgtgacttc ctccccggaa tatgtatggg acgcctttcc ggtgcacccc
     9721 ttcgattacc tgctcaaacc ctatcaggag gaaaaattcg tgcaccttgc cgccgagctg
     9781 cggcgggcgc tgcgttgtaa ggagccggaa ctggagattc gcattgcccg ccaaagcatt
     9841 cagctgccgc tgcgcaaggt gctgtatgcc attgcccgga accactacgt ccttatcacc
     9901 accgaggatg gcgagtaccg cgccatatgc agttttgcgc agatcgaaga aaagcttact
     9961 gctctggaaa actttatgag ctgcaaccgg ggcgttatca tcaacatgga caaggtgctg
    10021 cggttcgggg aggactgcat cgagatcttg gacggcaccc gcctgccggt acggcagaag
    10081 gataaatgca ctctgcttgc ccactttaca caataccagt tccgccacat gcggcaggag
    10141 ctgcactgag gaaaggagca gccgccatgg atcttgctct gttcggccgt tattttctgg
    10201 attttgcgct gctgtatccc agcgcgtttc tgtgtctggc atccctatgg gaaaagctgc
    10261 gcacccccaa gcgcaccgcc tgcatcgctg ccggatgcat caccctgctg tgcatcggct
    10321 gcgccgcgct ctgcgccgtg ttcgggctga gcagcaattc tctcctgccc gccatcgtgc
    10381 tggtctcctt ctggctgctg cgctggcggg taacgccgga agtgaccgta agccagaccg
    10441 cgtttctgtt ttccatctct gccgtgatga tggcggtgtg ttccctgctg tcgacgctgc
    10501 tcaacgccca gaccgagatc tccaacccac agaccgtctg ccttgcctcc acggcgctgc
    10561 tgcggctggg ccttgccgcg atgctcaccg tgctgttctg gttcaccgcc gtgcagtgga
    10621 gccggtggct gctgcgggag tacagcggtg aagccttctg gcagtctgcg tggccgctgc
    10681 ccgccctcta tgccgttttt ctggtatact gtatgccgct gaaccccgcc gtggtgctgg
    10741 tcgggcggct gaagatcatc tcggtgctgg cggtatccat ctcgctgttc ggcatctttc
    10801 tgctgctgta cgagatgtac cgcgttgccc gggagttcgc ccgcaatgcc cggctggacc
    10861 gggaaaacca gctgctggcc atggaatccc gccggtacat ggagttacag acctatctgg
    10921 acaacacccg ccgtctgcgg cacgacttcc ggcagcatct gcatgtgatt gccggactga
    10981 ccgagaccgg gcagctggag gagctgaaaa gctatctgca ccagtatgaa agcgaactca
    11041 gtgagcaccg ccccagcctg tgcgccaacg ccgccgtgga tgcactggcc ggatattatg
    11101 accatgcagc cgggcagcag agcgttcctg tggagtggaa gctggcactg ccccggcagc
    11161 ttcccatgcc ggaggccgac ctgtgcacca ttctgggcaa tctgctggaa aacgccctgc
    11221 acgccagcca gaagctgccg ccggagcagc gccgggtgca ggtgatggcg cagatgctca
    11281 gtcccgccat gctggggctt gtggtggaga accgttacga cggcatgctg aaaaaacagc
    11341 agggcatcct gcgctccacc aagcacgagg gcaccggcat cgggctggta tctgccgaga
    11401 cggtagtgca caaatataac ggcaatctgc atctggagac cgaggagcag atcttccggg
    11461 taaatgttct gttaaatctg taaccaccgg caggccaacg tgaaagcgtt cacaaaaaaa
    11521 gcagcgccgt cctttgcaga gaggtttctc tacgaagggc ggcgctgtat tatttttcaa
    11581 gcttctccgt gcttttttgt gcggcttcca gctcgtccac ccgcttttgc agggcggtga
    11641 tcttatcgtc cattttcaaa aatgtccaga ccagaacggc cagcaccagc gcgggaggaa
    11701 cgaccatcca cagggactgc tgacaccaga gcagcagcga atagccgccg aatacagtaa
    11761 aaataaatac ggcaaacaaa cttgcagcca gtacagcaaa aaatcccata cagaaagtct
    11821 cctttcagtt attcttccgt ttcttcctcg tccgggtcca gctcaatgct gaacacggct
    11881 tttttcagct tgccgcagcc ctgcgccttc aggccggatt tatacggttc ccccgccaga
    11941 tacaaggcaa agcgtccctc gcacagcatt ccggcaatgc tggtaccggc agtgcctacg
    12001 gtggtgtcgg cggcttcatc ggttggcttg gtgggcgtca gctccgcaag gcttacctca
    12061 aacagctcac tgccgtccaa gtcagtctcc agcgtaatgt gattgtcgtg ccgctggaac
    12121 agtgccttgt cggaggtctg gggcgtgacg gtgctcacgg tgaccaccgc cttgtcccca
    12181 tcgatgcggg tgcgcccggc aggcagggtg gtgatatccc gcgccatgat gtactcgatc
    12241 acggtgtcca gattgtcgct tacgcccaga tagttgggca ggttgttcag ggtatcgtag
    12301 atcatagaaa aagtcctccg tctgtgttgt ttcagttacc tgtatggtat cacaggtcag
    12361 ggacagatgc aatatgtgtg cgggcagatg tcgcgagccg cgcagaaaag gaacccgggt
    12421 cgcggctccc agcggctgca tcgtgccttg ggcggcacgc gcatcctgct ggccgcagcc
    12481 ccaacagctc ctccctgttt ctgccgctgg cagcggtcgt cgctgttgct gttcgaatcc
    12541 acccttgcag ccccttttgc aagacagata aaacagaaac tccggtaccc attggatacc
    12601 ggagttcttg gtgggcgcgg gtggattcga accaccgaag ctgaaagcag cagatttaca
    12661 gt
//
