LOCUS       c00023_gnlPro..        12452 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GPHLAPMJ_23.
ACCESSION   c00023_gnlPro..
VERSION     c00023_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 07:09:46
            Original ID  :: gnl|Prokka|GPHLAPMJ_23
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12452
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12452
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6844:12450]"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      6845..12450
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
     cand_cluster    1..12452
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /kind="single"
                     /product="acetate2butyrate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12452
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="acetate2butyrate"
                     /region_number="1"
                     /rules="(not (POR or POR_N or PFOR_II) and minimum(4,
                     [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF, ETF_alpha,
                     HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and minimum(1,
                     [EC1_2-faecali, ECH1_Enoyl_CoA_DH1, ECH1_Enoyl_CoA_DH2,
                     ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4, Thiolase_C]))"
                     /tool="gutsmash"
     CDS             complement(2..76)
                     /locus_tag="ctg23_1"
                     /transl_table=11
                     /translation="MMKVKPVKLGKTERMSFSHIDEVIS"
     CDS             complement(553..1635)
                     /locus_tag="ctg23_2"
                     /transl_table=11
                     /translation="MQKLSQTEELARSLAAKAHRHTLTTEQISRAMEEADFDIAQLDEL
                     YAALEQRGVHLAEEEPAELPVLDDAQIGRLENELSSEGVALDDPVKTYLKEIGRVPLLT
                     AGQEMALAKAARAGDADARRALSEANLRLVVSVAKRYAGRGLPFLDLIQEGNLGLMKAA
                     EKFEPERGFKFSTYATWWIRQSITRAIADQGRTIRIPVHLVESINRVKKTAGDLLHKNG
                     REPTVEEIAAALDMEPDKVRELLQLSQEPISLETPVGEEEDAHLEDFIQDEDAGVPVDE
                     AGRQLLRRELLHVLKSLTPREERVITLRFGLEDGRARTLEELGKEFNVTRERVRQIEAK
                     ALRKLRHPSRAKLLRDYLDE"
     CDS             complement(1684..3459)
                     /locus_tag="ctg23_3"
                     /transl_table=11
                     /translation="MIPHEYIEELTRRTDIVELVGSYVQLKRKGRLYGGLCPFHSEKTP
                     SFYVYPDTQSFYCFGCQAAGDAISFVKKINNISSGEAIKMLASRAGMPEPQEDDKTGRL
                     RSRVLSMNKEAARFFHACLNSTVEEARQARAYWRRRGLDDKTIVRFGLGYAPNDGQALY
                     QYLRDKGYNQQELDASGLFKRSQSGRIYCLFWKRVMTPIFDLRGNIIAFGGRVMDDSKP
                     KYVNSPETLVYHKSETVFAMQIAKRSASRRFVLCEGYMDVISMQQAGIDTAVCACGTAL
                     TPGQVRIISEYADEVILSYDSDEAGQKATLRSLELFRNSPVKVGVLQIPGAKDPDEYIK
                     KYGPERFQALLDGVGNALDFRLKRLRDQYDLSQDAQRLQYIKDAVEMLAERSNPTEQEV
                     YAGRLAEETNISKTAILAQLGTAVKRAGGKYRREKNRELLRSGEMNQIKVPYSAGGSQA
                     LGIASAQQRLLAAILREPRYLELAKQQLTAEQFIQPQQKELYEAMLNCSREGVELSLTA
                     LRAFVSEEALNELSRLAAQYSDVNCTPDDIRLYLDRIARGMPVASKAAAMSGDEITQYL
                     QSMREKKQGTLPEQD"
     CDS             complement(3485..4483)
                     /locus_tag="ctg23_4"
                     /transl_table=11
                     /translation="MDVRRRTEEIEHLTFAPWATFSDASRGRVVPEPQDPLRPVFQRDR
                     DRVLHCKAFRRLKQKTQVFLSPEGDLYRTRLTHTLEVSQIARTIARGLRLNEDLTEAIS
                     LAHDLGHTPFGHAGEKALNALCPDGFHHYMQSLRVVDRLEKDGEGLNLTWEVRNGIVTH
                     TKGTWAATPEGRIVRLADQIAFVNHDIEDAVRAGVLDAATLPKDCTAVLGQTKSARITT
                     MINSILTHSEEDVRMGTEEYEAFLALRDFMYATVYVDKNAKREEQKVDKLIAELYEYYL
                     THVDQMSNFYVQLAYQEGRERAVTDYISGMSDEFAIRTFEELFVPQKWHVL"
     CDS             complement(4626..5246)
                     /locus_tag="ctg23_5"
                     /transl_table=11
                     /translation="VEDYRTVRGTATGEYEEKKSRFIAQLSFADSEEAAVAFLEQVRAA
                     NRTARHNVYAYRLRAGNRERYSDDGEPAKTAGTPALEVLQHSGLTDLIVVVTRYFGGVL
                     LGTGGLVRAYTTATARALENAEVVTVRSVVELQVTVDYALYERASLLIDAAGAKQAPPE
                     FTDRVTLRWQMPEHTEAPLLEQLRELTRGSAQVTVSDPFYAPF"
     CDS             complement(5360..6298)
                     /locus_tag="ctg23_6"
                     /transl_table=11
                     /translation="MKRAMSTVKNIAAAAMTLAVFFGFAGFKPVTANAAQAAMPATASV
                     EEENSYFEEDAYQRSFLTLINNERAQAGLAPVALGDSNHNAAAMERAEELAVSYSYVRP
                     NGQRDFTVLAENGISDVSIGENYMAGCSTPDSAMDQWMATDFTRERILNADATTVSVGY
                     YEGGVYNNYWVLIFSYPENSHTEDYRQEVLDLVNAQRAKYGLTALKMGDDALTAAAQTR
                     AEEIAVVNSHVRPDGSKCFTVLKDYGVTDTPTGENAAWGSVSPEEVVNAWMNSEGHRAN
                     ILNPEARKMSVGYYYNSNSTWGHQWIQIFTK"
     CDS             complement(6845..7939)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF_alpha"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1009:Electron-transferring flavoprotein (Score: 111.7;
                     E-value: 4.4e-35)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_7"
                     /sec_met_domain="ETF (E-value: 1.3e-47, bitscore: 151.7,
                     seeds: 129, tool: rule-based-clusters)"
                     /sec_met_domain="ETF_alpha (E-value: 8.4e-36, bitscore:
                     111.7, seeds: 511, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADFNEYKGVWVFCEQRQGALMSTDFELVSEARKLADELGCEVTG
                     LLLGDNVEGIAKELGGYGADKVLVCDSPLLKDYTTDAYAKVVCDMVNEYKPEVLLIGAT
                     NIGRDLGPRCAARLHTGLTADATHLDIDTAKYIDFLKESSTIDLSKQKFDMEDRNLKMT
                     RPAFGGHLMATIICPRFRPQMSTVRPGVMKKAPFDQAKADACQIVKPAFSLTAEDIKTE
                     VLSVEKAAEKLVDLIGADVIVSVGRGISKDVNKGIELAEQLAAALGGGVVGASRAVTDA
                     GWMTADHQVGQTGKTVHPKIYVALGISGAIQHTAGMQDSECIIAVNKNEGAPIFGVADY
                     GIVGDLFKVVPELIKQIEAAKAAL"
     CDS             complement(7961..8755)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 157;
                     E-value: 1.6e-48)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_8"
                     /sec_met_domain="ETF (E-value: 3e-49, bitscore: 157.0,
                     seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAIVCVKQVPDTSGKVSVKPDGTLDRASMATITNPDDLNALEAA
                     LKLKDATGCEVVVVTMGPPPAEGMLRELLARGADKAVLVSGREFGGSDTFATSQILAAA
                     VNKIGVGPEDVVFCGRQAIDGDTAQVGPQIAEKLHLPQVTYVADIQKDGNTLTVKRMLE
                     DGYMMVKVQTPCLLTCIKELNDPRYMSVNGIFTCYDKPMEVFDYNALKDDPLIEVDTIG
                     LKGSPTNVFKSFTPPQKGAGTMLQGDDVAAQLAGILAKKHLI"
     CDS             complement(8773..9942)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_9"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 3.6e-50, bitscore:
                     159.8, seeds: 49, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 4.5e-30, bitscore:
                     93.5, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.3e-40, bitscore:
                     128.4, seeds: 796, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFTLSKQQQMVQKMYREFAENEVKPLAKKVDAEEYFPKETVEKM
                     GKLGMMGIYFPTEVGGAGGDVLSYVMAVEELSKVCGTTGVIVSAHTSLCAAPIYENGTP
                     EQKAKYLPKLCSGEWLGAFGLTEPGAGTDAQGQQTIAKEDGDYWVLNGSKIFITNAGFA
                     DVFIVIAVTDNVLDKRGRPTKLCSAFIVERTDPGFSVGKAEDKMGIRGSSTCELIFEDC
                     RIPKDRMLGVRGKGFQLAMATLDGGRIGIASQALGIAEGALEETIAYVKERKQFGRAIA
                     AFQNTQFELAEMKARVEAAKYLVYAAALKKQQAMDGAKVRYSVEAAQAKLIAARTASDV
                     TRRCLQLFGGYGYTRDYPIERMMRDAKITEIYEGTSEVQMMVISGALLK"
     CDS             complement(10050..10922)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_10"
                     /sec_met_domain="HCDH (E-value: 9.2e-35, bitscore: 109.0,
                     seeds: 68, tool: rule-based-clusters)"
                     /sec_met_domain="HCDH_N (E-value: 7.2e-62, bitscore: 198.1,
                     seeds: 60, tool: rule-based-clusters)"
                     /sec_met_domain="F420_oxidored (E-value: 6.7e-08, bitscore:
                     22.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIGVIGAGTMGQGIAKAFAQVEGNTVALCDIKQEWAENGLAKIK
                     KGYEKLVAKGKMTQEKADAIVAAITPGLKEDLCADCDLVVEAAFEDMKVKQTTFGELDK
                     ICKPECIFASNTSSLSITEIGKGLTRPLIGMHFFNPADRMKLIEVIAGCNTPAETVEKI
                     KEIAVAIGKSPVQVNEAAGFVVNRILIPMINEAAFIKMEGVSDIAGIDTAMKLGANHPM
                     GPLELGDFIGLDICLAIMDVLYNETGDSKYRACPLIRKMVRGGNLGCKTGKGFYVYNAD
                     RTKTPVDQL"
     CDS             complement(10962..11747)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: EC1_2-faecali"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_11"
                     /sec_met_domain="EC1_2-faecali (E-value: 1.5e-93, bitscore:
                     302.3, seeds: 67, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAFVKTEVQGAVEIITIDRPKALNALNPEVLADLKAAFEAVDQET
                     VRCIVLTGEGDKSFVAGADIGSMSTMTKAEGEAFGKLGNDVFLMIEHFPIPVIAAVNGF
                     ALGGGNELAMSCDIRICSDNAVFGQPEVGLGITPGFGGTQRLARLVGMGMAKQLVYSAL
                     NIKADEAYRIGLVNAVYPQAELMENVLKLAGKIAKNAPIAVRNCKKAMNDGISLPIEKA
                     VEVEEKLFGACFETHDQQEGMACFLSREKPKPKAVFTNN"
     CDS             complement(11872..12450)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Thiolase_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Thiolase_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_12"
                     /sec_met_domain="Thiolase_N (E-value: 4e-23, bitscore:
                     71.7, seeds: 30, tool: rule-based-clusters)"
                     /sec_met_domain="Thiolase_C (E-value: 9.3e-50, bitscore:
                     157.1, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VPVVIKGKKGDTVFDTDEGPRLSAPEVLAKLKPAFTKDGIVTAGN
                     SSAINDGAAALVVMSEEKAKELGVKPLATWVAGALAGVEPEVMGLGPIAATKKVMAKTG
                     MTVADMDLVEANEAFAAQSIAVGEALGFDKDKLNVNGGAIALGHPVGASGARILVTLLY
                     AMKHRGAHKGLATLCIGGGMGCATIVEMD"
ORIGIN
        1 tactgatgac ttcgtcgatg tgggagaagc tcatgcgctc ggttttgccg agctttacgg
       61 gcttgacttt catcataaaa tcaaccactc cttactttta tattctacgg gatgtcgtat
      121 acgcgggtca aatttgagca gacacacata attcgacccg cgtcctgcgg aaccttccgg
      181 cattttgcac aaacttttcg gggtgacccc tcaagcggca gccatcacag ttcccttttt
      241 gacgcactag tccattatgt gatactaatg cagtatacac cccaaaaccc ctgttgtcaa
      301 gccatttttc agttttttgc cgaaataaat ttaattttcg gtttgttttc gaacgcccgg
      361 cagcgtgtag tcgtttgttt tccaagtact tgattttttt attttgcacg ttcctgttca
      421 taataccctt gtgcaatttg tctatctttg ctcttgcgcc cggaggtatt acttttccgc
      481 ttccctgccg caaaaagaag agaccgccgc acggaacgcc gtgcagcggc cttgtcctat
      541 tatatagaat gctcactcgt ccagataatc ccgcagcagc tttgcgcggc tggggtggcg
      601 cagcttgcgc agcgcctttg cttcgatctg acgcacccgc tcccgggtca cgttgaactc
      661 cttgcccagt tcttccaggg tgcgggcacg gccatcctcc agaccaaagc gcagggtgat
      721 gaccctctcc tcccggggcg tcaggctttt aaggacgtgc agcagttccc gccgcagcag
      781 ctggcgcccg gcttcgtcca ccgggacacc ggcgtcctcg tcctgaataa agtcctccag
      841 atgggcgtcc tcttcctccc ccaccggcgt ttccagactg atgggttcct gcgacagttg
      901 cagcagttcc cgcaccttgt ccggctccat atccagtgcg gcggcgatct cctccacggt
      961 gggctcccgc ccatttttgt gcagcagatc gcccgccgtt ttcttgaccc ggttgatgct
     1021 ctccaccaga tgcaccggga tacggatggt gcgtccctga tccgcaatgg cgcgggtgat
     1081 ggactgacgg atccaccagg ttgcgtaggt ggagaacttg aagccccgct ccggctcaaa
     1141 cttttccgct gccttcatca ggccaaggtt gccctcctga ataagatcca gaaaaggcag
     1201 tccacgcccg gcgtagcgct tggctaccga taccaccagc cgcaggtttg cctcgctcaa
     1261 agcgcggcgg gcatctgcat ccccggcccg ggcagccttt gccagcgcca tctcctgccc
     1321 ggcggtcagc agcggcaccc ggccgatctc ctttaaatag gtcttgaccg gatcatccag
     1381 tgccacaccc tccgaggaaa gctcattctc cagcctgccg atctgggcat catccagcac
     1441 aggcagctcg gcaggctcct cctctgccag atgaacgccc cgctgctcca gcgccgcgta
     1501 aagctcgtcc agctgtgcaa tatcaaaatc cgcttcttcc atggcacggc tgatctgctc
     1561 cgtggtcagg gtgtgacggt gagccttcgc ggcaaggctg cgggcaagtt cttccgtttg
     1621 cgacaatttc tgcatgattc ctgctccttt tctctccagc tccagccgga gggaaaacag
     1681 ggatcagtct tgttcgggca gagtcccctg ctttttttcg cgcatcgact gaagatactg
     1741 tgtgatctca tcgccggaca ttgcagcagc tttgctagca accggcattc cccgggcgat
     1801 cctgtccaga tacagacgga tatcgtccgg ggtgcagttc acatcgctgt attgtgccgc
     1861 aagccggctc agttcattca atgcttcttc acttacaaat gcccgcagtg cagtcaggct
     1921 gagttccaca ccctcccggc tgcaattgag catcgcttcg tatagttcct tctgctgcgg
     1981 ctggatgaat tgctccgccg tcagctgctg cttggccagt tccagataac gaggctccct
     2041 cagaatagca gccagcagcc gttgttgggc gctggcgatg cccagcgcct gactgccgcc
     2101 tgcgctgtaa ggcaccttga tctgattcat ctcaccggag cgcagcaact cgcggttttt
     2161 ctcccggcgg tacttgccgc ccgcccgctt tactgcggta cccagctgcg ccagaatggc
     2221 agttttggag atgttggtct cctctgccag ccgcccggcg tacacctcct gctcagtggg
     2281 gttggagcgc tctgccagca tttccacagc atcctttata tattgcagac gctgtgcatc
     2341 ctgcgagaga tcatactggt ctcgcaggcg cttgagccgg aagtccagcg cattgcccac
     2401 cccgtccaga agtgcctgaa aacgctccgg gccgtatttt ttgatgtatt cgtccgggtc
     2461 ctttgcgccg ggaatctgca aaacacccac ctttaccggg ctgttgcgga acagttccag
     2521 tgagcgcagg gtcgccttct ggccagcctc gtccgagtca tagctcagaa tgacctcatc
     2581 ggcatactcg ctgatgatgc gcacttgccc gggggtcagg gcggtgccgc aggcgcagac
     2641 ggcggtgtcg atgcccgcct gctgcatact gatgacatcc atgtagcctt cgcacagcac
     2701 gaaccgccgg gaggcgctgc gcttggcgat ctgcatggca aacaccgtct cggatttgtg
     2761 gtagaccagc gtttccgggc tgttgacgta tttgggcttg gagtcgtcca tcacgcgccc
     2821 gccaaaggca atgatgttgc cgcgcaggtc aaagataggg gtcatgacac gcttccagaa
     2881 cagacagtag atgcgcccgg actggctgcg tttgaacaag ccgctggcgt ccagttcctg
     2941 ctggttatag cccttatccc gcaggtactg gtacagtgcc tgcccatcgt tgggggcata
     3001 gcccagcccg aaccggacga tggtcttatc gtccagcccg cgccgccgcc agtaagcgcg
     3061 cgcctgccgt gcctcctcca cggtagagtt caggcaggcg tggaagaagc gggcggcctc
     3121 cttattcatg gaaagcaccc ggctgcgcag acgtccggtc ttgtcgtcct cctgcggctc
     3181 cggcataccg gcgcgggaag ccagcatctt gatagcttcg ccgctgctga tattgttgat
     3241 ctttttgaca aagctgatgg catctccggc tgcctgacag ccgaagcagt aaaagctttg
     3301 ggtgtccggg tacacataga aggacggcgt tttttcgctg tgaaaggggc acagaccgcc
     3361 gtacagccgt cccttgcgct tgagctgcac atagctgccc accagttcca cgatgtcggt
     3421 gcggcgggta agttcctcga tgtattcatg tgggatcatg ttgttttaaa cgacctctcc
     3481 agttttaaag gacgtgccat ttctggggca cgaacagttc ttcaaaggtg cggatggcaa
     3541 actcgtcgct cataccgctg atatagtcgg tgacggcgcg ttcccgtccc tcctgatagg
     3601 ccagctgcac ataaaagttg gacatctgat ccacatgggt caagtagtac tcgtacagtt
     3661 ccgcgataag cttgtccacc ttctgctcct cgcgcttggc gtttttgtcc acatacacgg
     3721 tggcgtacat gaaatcccgc aaagcgagaa aagcctcgta ttcctcggtg cccatgcgga
     3781 catcttcctc gctgtgggtg aggatgctgt tgatcatagt ggtgatgcgg gcggacttag
     3841 tctgccccag cactgccgtg cagtccttgg gcagggtggc agcgtccagc acaccggcgc
     3901 gcacggcgtc ctcgatatcg tggttgacaa aggcgatctg atccgcaaga cgcacgatac
     3961 gcccttccgg ggtagccgcc catgtgccct tggtgtgggt aacgatgccg ttgcgcacct
     4021 cccatgtcag gttaaggccc tcgccgtcct tttccagccg gtctaccaca cgcaggcttt
     4081 gcatataatg gtggaagccg tccgggcaga gagcgttcag tgccttttcg cctgcgtgtc
     4141 caaagggagt gtgccccaga tcatgcgcaa ggctgatggc ctcggtcaga tcctcgttca
     4201 ggcgcagacc ccgggcgatg gtgcgggcga tctgcgaaac ttccagcgta tgggtcaacc
     4261 gggtgcggta caggtcacct tccggcgaga ggaacacctg cgttttctgc ttgagacgcc
     4321 ggaaggcctt gcagtgcagc acccggtcgc gatcccgctg gaacaccggg cgcagcgggt
     4381 cctgcggctc cggcacgact ctgccgcggc ttgcatcgct gaaggtcgcc cacggtgcaa
     4441 aggtgaggtg ttcgatctcc tcggttctcc ggcgcacatc catacagatc ctccttttgt
     4501 ttttcgggct tctcccctcc cctctgcgca cagccgatcc caattgctgc gctacggcaa
     4561 ttgtagcaca tcggccatgt cgaaggggga agttcggtgt cggtttgcaa aaaagacttt
     4621 gttttttaaa atggtgcgta gaacgggtca gacaccgtta cctgagcgct gccccgggtc
     4681 agttctcgca gctgctccag cagcggggct tcggtatgct ccggcatctg ccagcgcagg
     4741 gtgacccggt ctgtaaactc cggcggtgcc tgctttgccc cggcggcgtc aatgagcaga
     4801 gatgcacgct cgtaaagggc gtagtccact gtcacttgta attccaccac gctgcgcaca
     4861 gtgaccacct cggcgttttc cagcgcacgg gcagtggcgg tagtgtaagc gcgcaccaag
     4921 ccgccggtgc ccagcagcac cccgccaaag tagcgggtga ccaccacgat caggtctgtc
     4981 aggccgctgt gctgcaacac ttccagcgcg ggcgtaccgg cggtcttggc cggctcgccg
     5041 tcatcggaat agcgctcgcg gttgcccgcc cgcaggcggt aggcgtaaac attgtgccgc
     5101 gcggtgcggt tggctgcccg cacctgctcc agaaaggcca cagcggcttc ctcactgtca
     5161 gcaaaggaaa gctgtgcgat aaagcggctc tttttctctt cgtattcgcc ggtggccgtg
     5221 ccccggacgg tgcggtaatc ctccacgtta gatcctcctg ataataactc agaataagta
     5281 taacacaaac gggcgcaaat aaaaagactg acgaagcctt gcggccccgc cagtcttttt
     5341 ataagaagaa agcagttaat cacttggtaa agatctggat ccactgatgg ccccaagtgc
     5401 tgttgctgtt gtagtagtaa ccaacactca tcttgcgagc ctcagggttc aggatattgg
     5461 cacgatggcc ttcggagttc atccatgcat tgacgacttc ttcaggagag acgctgcccc
     5521 atgcggcatt ctcgccggtg ggggtatcgg tgacgccata gtccttcagg acggtgaagc
     5581 acttagagcc atcgggacgg acgtgggagt tcacaacggc gatctcctcg gcgcgggtct
     5641 gtgcagcggc ggtcaaagcg tcatcgccca ttttcagagc agtcagacca tactttgcgc
     5701 gctgggcatt gaccagatcc agaacttcct gacggtaatc ctcggtgtga gaattttcgg
     5761 ggtaagagaa gatcagcacc caatagttat tgtaaacacc gccctcatag tagccaacgc
     5821 tcacggtggt agcatcggcg ttcaggatac gctcgcgggt gaagtcggta gccatccact
     5881 gatccattgc ggaatcgggg gtggagcagc cggccatgta gttctcgccg atggagacat
     5941 cgctgatacc gttctctgcc agaacggtga aatcgcgctg accgttggga cgaacgtagg
     6001 agtaagaaac tgccagctct tcggcacgct ccattgcagc ggcgttgtgg ttgctgtcgc
     6061 ccagagcaac aggagccaga ccagcctgtg cacgctcgtt attgatcagg gtcaggaagc
     6121 tgcgctggta agcgtcttcc tcaaagtagg agttctcttc ttccacagaa gcggtggcag
     6181 gcatggcagc ctgtgcagcg tttgcggtga cgggcttgaa gcctgcaaag ccaaaaaaca
     6241 cagccagcgt cattgcagct gctgcgatat tcttcacggt actcattgca cgcttcataa
     6301 gattgcctcc ggtctgttgc cttatgcagt gtgatcttgg atattgcaac tcgtttgcaa
     6361 ctctgtcgta tcacatccgc aactcttgtg taacaagagt atcacaaaac catacagacg
     6421 tcaagaggtt tagagcttga tttgcagaaa aaatacagat tttttaaaaa attctcgcct
     6481 ttttatcgca actcaagcgt aacaaagagt ccgaaaacgt tacagttgtg ttgcgcttct
     6541 cgccaaaaca agccaagtgc aacagcttcc gcacactttt tgggacactt cggtgcgttt
     6601 cgttttgtat attactgtat ttatatgcac cgctttgcat atcgtggttt ctgtgtacgt
     6661 ttttgtggcg cttcgctgtg ttcccttctg cgttcctttc ctgtggagca aatcggagct
     6721 gctgtgcagt ggccggcaca acagctcctt tataaaaagc acaaaaaaga ggccgctgca
     6781 caaaaatgtg caacggcctc tcacaattca ggctatgcta ttgaactatg ctcgggtcag
     6841 atgatcacag agcagccttt gctgcctcga tctgcttgat cagctcgggc acgaccttga
     6901 acaggtcgcc cacgatgccg tagtcagcaa caccgaagat gggagcaccc tcgttcttgt
     6961 tgacggcgat gatgcactca gaatcctgca taccggcggt gtgctggata gcaccagaga
     7021 tacccagagc cacatagatc ttggggtgca cagtcttgcc ggtctgaccg acctgatggt
     7081 cagcggtcat ccagcctgca tcggtgacgg cacgggaagc gcccacgaca ccgccgccca
     7141 gagcggctgc cagctgctcg gccagctcga tgcccttgtt gacatccttg ctgataccac
     7201 gaccaacgga gacaatgaca tctgcgccga tcaggtcgac cagcttctca gcggccttct
     7261 ccacgctcag cacttcggtc ttgatgtcct cagcggtcag gctgaaggcg ggcttgacga
     7321 tctggcaggc atcagccttg gcctgatcga agggagcctt cttcataacg ccgggacgca
     7381 cggtggacat ctggggacgg aagcgggggc agatgatggt agccatcaga tggccgccga
     7441 atgcgggacg ggtcatcttc aggttgcggt cttccatatc gaacttctgc ttggacagat
     7501 cgatggtgga gctctccttc aggaagtcga tgtactttgc agtatcgata tccagatggg
     7561 tagcgtcggc ggtcaggccg gtgtgcagac gggctgcgca gcggggaccg aggtcacggc
     7621 caatgttggt agcgccgatc agcagcacct caggcttgta ctcgttgacc atatcgcaca
     7681 cgaccttagc gtatgcgtcg gtggtgtaat ccttcagcag ggggctgtcg cagaccagaa
     7741 ccttgtcggc accgtagccg cccagttcct tggcaatgcc ctccacgttg tcgcccagca
     7801 gcagaccggt gacctcgcag cccagctcgt cggccagctt acgggcctcg ctaaccagct
     7861 cgaagtcagt ggacatcagt gcgccctggc gctgctcgca aaagacccat acgcccttgt
     7921 attcgttaaa atcagccatt gtaatcctat gctcctttca tcagatcagg tgcttcttgg
     7981 ccaggatgcc agccagctgg gcggcaacat cgtcgccctg cagcatggtg cctgcgccct
     8041 tctgcggagg agtgaaggac ttaaagacgt tcgtcggaga acccttcagg ccaatggtgt
     8101 ccacctcgat cagcggatcg tccttcagtg cgttgtagtc gaacacttcc atgggcttat
     8161 cgtagcaggt aaagataccg ttcacgctca tgtagcgggg gtcgttcagc tccttgatgc
     8221 aggtcagcag gcagggagtc tgcaccttga ccatcatgta gccgtcttcc agcatacgct
     8281 tcacggtcag ggtgttgccg tccttctgga tgtcggcaac gtaggtgacc tgcggcagat
     8341 gcagcttttc agcgatctgg gggccgacct gtgcggtatc gccatcgatt gcctgacggc
     8401 cgcagaacac aacgtcctca gggccaacac cgatcttgtt gacggcagca gccaggatct
     8461 ggctagttgc aaaggtatcg gaaccgccga actcacggcc ggagaccagg acagccttat
     8521 cagcgccgcg ggccagcagc tcacgcagca tgccctctgc cggcggggga cccatggtaa
     8581 caacaacgac ctcgcagccg gtggcgtcct tcagtttcag ggcggcctcc agagcgttca
     8641 ggtcatcggg gttggtgatg gttgccatgg atgcacgatc cagagtgcca tcgggcttga
     8701 cggacacctt gccggaggta tcaggaacct gctttacaca aacaattgct ttcattgtaa
     8761 ctcttgcctc ccttacttca gcagcgcgcc ggaaatgacc atcatctgca cttcgctggt
     8821 gccctcgtag atctcagtga tcttggcatc acgcatcatg cgctcgatgg ggtagtcacg
     8881 ggtgtagccg taaccaccga acagctgcag gcagcggcgg gtcacatcgc ttgcggtgcg
     8941 ggctgcgatc agcttggcct gtgcagcctc gacgctgtaa cgaacctttg cgccatccat
     9001 agcctgctgc ttcttcagag cggcagcata aaccagatac ttagcagcct caacacgagc
     9061 cttcatctca gccagctcga actgagtgtt ctggaaagca gcaatggcac ggccgaactg
     9121 cttgcgctcc ttgacgtaag caatggtctc ctccagagcg ccctcggcga tgcccagagc
     9181 ctgagaagcg atgccgatac ggccgccgtc cagcgtagcc attgccagct ggaagccctt
     9241 gccgcgcacg cccagcatac gatccttcgg gatgcggcaa tcctcaaaga tcagctcaca
     9301 ggtagaagaa ccgcggatac ccatcttgtc ctctgcctta ccaacagaga agcccgggtc
     9361 ggtgcgctcc acgatgaaag cggagcagag cttggtggga cggccgcgct tatccagcac
     9421 gttatcggta acggcgatga cgatgaagac atcagcaaag cctgcattag tgatgaagat
     9481 cttggagccg ttcagcaccc agtaatcacc atcttccttg gcaatggtct gctgaccctg
     9541 cgcatcggta ccagcgcccg gctcggtcag gccgaaagca cccagccact cgccgctgca
     9601 gagcttcggc aggtacttag ccttctgctc gggggtgccg ttctcgtaaa tgggagcagc
     9661 gcacaggctg gtgtgagcag agacgatgac accggtggtg ccgcagacct tgctcagctc
     9721 ttccactgcc atgacgtagg acagcacatc gccgcctgca ccgccgacct cagtcgggaa
     9781 atagatgccc atcatgccca gcttgcccat cttttcgacg gtctccttgg ggaagtattc
     9841 ctctgcgtca accttctttg ccagaggctt gacttcgttc tcagcaaact cgcggtacat
     9901 tttctgcacc atctgctgct gcttggacag agtaaaatcc atcgctatat cctcctaaca
     9961 ggtctttttt tcatttaccg gaatagcccg gtgcaaacaa attcctcccg accgctttcc
    10021 ccgcagccgg gagaaatgtt tatcagaact tacagctggt caacaggggt cttggtacgg
    10081 tctgcgttgt aaacgtagaa gcccttaccg gtcttgcagc ccagattgcc gccacgcacc
    10141 atcttgcgga tcagcgggca ggcacggtac ttgctgtcgc cggtctcgtt gtacagcacg
    10201 tccataatgg ccaggcagat gtccagaccg atgaagtcgc ccagttccag gggtcccatg
    10261 gggtggttag cgcccagctt catggcggtg tcgatgccag cgatatcgga aacgccctcc
    10321 atcttaatga aggcagcctc gttgatcatg gggatcagga tgcggttgac cacaaagccg
    10381 gcagcctcgt tgacctgaac ggggctcttg ccgatggcaa cggcgatctc cttgatcttc
    10441 tcaacggtct cagcgggggt gttgcagccg gcgatgacct cgatcagctt catgcgatct
    10501 gcggggttga agaagtgcat accgatcagg ggacgggtca gacccttgcc gatctcggtg
    10561 atggacagag aagaagtgtt ggaagcgaag atgcactcgg gcttgcagat cttatccagc
    10621 tcaccgaagg tggtctgctt gaccttcata tcctcgaaag cagcctcaac gaccagatcg
    10681 cagtctgcgc acagatcttc cttcaggccc ggggtgatgg cggcgacgat agcgtcagcc
    10741 ttctcctggg tcatctttcc cttagcgacc agcttctcgt agcccttctt gatctttgcc
    10801 agaccattct cggcccactc ctgcttgatg tcgcacagag caacggtgtt gccctcaacc
    10861 tgtgcaaatg cctttgcgat gccctgaccc atagtgccag cgccgataac accgatcttc
    10921 ataggaaatc tctcctttaa tatcaaaaat tatataatgg attagttgtt ggtgaacact
    10981 gccttgggct tcggtttctc acgggacagg aagcaagcca tgccctcttg ctgatcgtgg
    11041 gtctcgaagc aagcgccgaa cagcttctcc tcgacctcaa cagccttctc gatgggcagg
    11101 ctgatgccgt cgttcattgc cttcttgcag ttacgcacag caatgggagc gttctttgcg
    11161 atcttgccgg ccagcttcag gacattctcc atcagctcag cctgcggata cacggcgttg
    11221 accagaccga tgcggtaagc ctcgtcagcc ttgatgttca gcgcagagta gaccagctgc
    11281 tttgccatgc ccatgccgac cagacgagcc aggcgctggg tgccgccgaa gcccggggtg
    11341 atgcccagac cgacttccgg ctgaccgaac acagcgttgt cagagcagat gcggatatcg
    11401 cagctcatag ccagctcgtt gccgccgccc agtgcaaagc cgttgacggc tgcgatgacg
    11461 gggatgggga aatgctcgat catcaggaac acatcattgc ccagcttgcc gaaggcctcg
    11521 ccttctgcct tggtcatggt gctcatagaa ccgatatcag caccggcaac gaagctcttg
    11581 tcgccttcgc cggtcagaac gatgcagcgg acagtctcct gatcaactgc ctcaaaagca
    11641 gccttcaggt cagccagaac ctcggggttc agggcgttca gtgccttggg acggtcgatg
    11701 gtaatgatct caacagcgcc ctgcacctcg gtttttacaa atgccattgt gaaaacctcc
    11761 atttcataca gttcagtttt tttcaaaaca gcccccggaa cgcgggaggg ttctccgttt
    11821 ccctccggcg ctccgggtct gtagttcagt caggattcag agaaagaatg cttagtccat
    11881 ctcaacgatg gtagcgcagc ccatgccgcc gccgatgcac agggtagcca gacccttgtg
    11941 agcaccacgg tgcttcatag cgtacagcag ggtgaccagg atacgagcgc cggaagcgcc
    12001 gaccgggtga cccaaagcga ttgcgccgcc gttgacgttc agcttgtcct tatcgaagcc
    12061 cagagcctcg ccgacagcga tggactgtgc tgcgaatgcc tcgttggcct cgaccagatc
    12121 catatcagca acggtcatgc cggtcttggc catgaccttc ttggtagcag cgatggggcc
    12181 cagacccatg acctcgggct caacgcctgc cagagcaccg gcgacccagg ttgccagagg
    12241 cttcacgccc agctccttag ccttctcctc gctcatgacg accagagcag cagcgccgtc
    12301 gttgatggcg gaagagttac cagcggtgac gatgccgtct ttggtgaagg cgggcttcag
    12361 ctttgccaga acctcgggag cgctcagacg ggggccctca tcggtatcga acacggtgtc
    12421 gcccttcttg cccttgatga caacaggaac ga
//
