LOCUS       gnlProkkaPIKNMKDH_296   9659 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PIKNMKDH_296.
ACCESSION   gnlProkkaPIKNMKDH_296
VERSION     gnlProkkaPIKNMKDH_296
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 05:15:14
            Original ID  :: gnl|Prokka|PIKNMKDH_296
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9659
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..360)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 145.9; E-value:
                     2.5e-44)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg296_1"
                     /sec_met_domain="NTP_transf_3 (E-value: 3e-13, bitscore:
                     40.1, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGIVLAGGSGTRLYPITKGVSKQLLPIFDKPMIYYPISVLMLAG
                     IREILIISTPDDLPGFQRLLGDGSDFGVRFEYAEQPSPDGLAQAFIIGEKFIGDDSVCL
                     VLGDNIFYGDGLTEMV"
     protocluster    1..9659
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[7245:7599]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7246..7599
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..9659
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..9659
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(363..755)
                     /locus_tag="ctg296_2"
                     /transl_table=11
                     /translation="MKNSLCNSVSSVVKKLLEYGEDGTPVYVNELTALNQELRNLCADL
                     LLQKGESPEEEAEILVTLFKGYDTMLFNFSSENEQVIQELLDRSMTVLEKLPASVLKCQ
                     LLLECFEQTGDEELIREAKKNIERVI"
     CDS             complement(938..1486)
                     /locus_tag="ctg296_3"
                     /transl_table=11
                     /translation="MLKLFLTNVVLETTDSDKHWYVVLTRTNSERKVRDYFQLQEVDTF
                     LPVQNRVIEREGKRIERERLLLPRMVFVHISRQEMAAVRSTLNVYDFLRDRSTGAPTCI
                     PDAQMADFRYMLDYSQDQVILTGESIPKGTRVVVAKGDLQGLRGELVRYNNKYHILVRI
                     DMFGSAMVTIPASYVRKEK"
     CDS             complement(1837..2022)
                     /locus_tag="ctg296_4"
                     /transl_table=11
                     /translation="MLTSYSSLIKILLFDNQLLIFWMRSAVKFFSYIQDVRSCLFIKLP
                     LRLSIACLSTYFHILL"
     CDS             complement(2170..2805)
                     /NRPS_PKS="Domain: oMT (51-151). E-value: 1e-15. Score:
                     48.5. Matches aSDomain: nrpspksdomains_ctg296_5_oMT.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 101.8; E-value:
                     6.9e-31)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg296_5"
                     /transl_table=11
                     /translation="MNKRGFVSRILQNFRKPEGFFGRMILWGMNTGHASLAQWGMSCLQ
                     WQPEWSVLDIGCGGGANLLQILQRCPQGKAYGIDISPESVTFARKKNKKYLGTRCFIEQ
                     GGVHRLPYPDYAFDAVTAFETVYFWGNLQHAFTEVARVLKPGGSFLICCEISDPANKAW
                     TGLVEGMEIHSCDELKAILSKSGFTDTAIFRTKKEELCLVSHRQTVRL"
     aSDomain        complement(2353..2652)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg296_5_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.00E-15"
                     /label="ctg296_5_oMT.1"
                     /locus_tag="ctg296_5"
                     /protein_end="151"
                     /protein_start="51"
                     /score="48.5"
                     /tool="antismash"
                     /translation="VLDIGCGGGANLLQILQRCPQGKAYGIDISPESVTFARKKNKKYL
                     GTRCFIEQGGVHRLPYPDYAFDAVTAFETVYFWGNLQHAFTEVARVLKPGGSFLI"
     CDS             3111..4451
                     /locus_tag="ctg296_6"
                     /transl_table=11
                     /translation="MNNVQQVKTYSQRKISDFLFILWAGGAALLSYSLVYALRKPYTAA
                     GFDGLEAFGMDYKVVVTIAQILGYVLSKFIGIKLISELKRENRMKFILISIILAEASLI
                     LFGLLPAPYNIGAMFLNGLSLGCMWGIIFSFIEGRRMTDILASLLGVSMVISSGTAKSA
                     GLYVMDTLNISEFWMPALIGGVALPLLALLGYALNRLPQPTAEDIAMKSKRETLNGKQR
                     WELFKNFMPFLTLLFIANVVLTILRDIKEDFLVKIIDVSQYSSWMFAQVDSVVTLIILI
                     IFGLMVFVRSNLKALSILLGLIIASMVVMAVVSFGYEQLQLNAIVWLFIQSLCLYLAFL
                     TFQTIFFDRFIACFKIRGNVGFFIAMNDFLGYTGTVIVLAVKEFFSPDINWTAFYNLMA
                     GYVGIICFVAFVCSFIYLHQRYRRENYGKTGVFRKKEEEKEVPDFVY"
     CDS             4495..6006
                     /locus_tag="ctg296_7"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIEHEPIASIDLMERAAQALTKAITERWDI
                     TTPVTVFAGPGNNGGDALAVARMLAEKEYKVEAYLFNPKGELSADCQTNKELVEMMDNV
                     KFSEVSTQFVPPALTMDHLVVDGLFGSGLNKPLSGGFAAVVKYINASPATVVAIDIPSG
                     LMGEENTFNVKANIIRAQLTLSLQLPKLAFLFAENSEFVGEWKLLDINLSREAIEETES
                     NYALLEAEEIHALIKPRNTFSHKGNFGHALLIAGSYGMAGASILAARACMRSGVGLLTV
                     HAPIRNNDILQISVPEAIIESDASDTYFACPTDTDDYQAVGIGPGIGRSEETEAALLEQ
                     LSGCQTPLVLDADALNILANHRHALTTLPKGSILTPHPKELERMVGKCQNSYERLMKAC
                     ELARTAKVHIILKGAYSAIITPSGKCYFNSTGNPGMATAGSGDVLTGVVLALLAQGYPA
                     EEAAKIGTYVHGLAGDFARKKQGVISMTAGDIISNLPLAWRLVSE"
     CDS             6079..7134
                     /locus_tag="ctg296_8"
                     /transl_table=11
                     /translation="MKKLIILTGLLLSTSAYAQTEVTAGVTRGKDYGVTYALPKTAINI
                     EVKVNKVTYTPGEFSKYADRYLRLTDVSGEPQEYWELVSVKAKSVGIPDSEHTYFVKLK
                     DKTVAPLIELTEDGIVKSINVPLSPKKSTPMQPATTQKKKINPRDFLTEEILMAGSTAK
                     MAELVAKEIYNIRESKNALVRGQADNMPKDGEQLKIMLANLEEQEAAMTEMFSGTLNKD
                     EKIFNIRLTPDKEMDNEVAFRFSKKLGIVANNDLAGEPVYITLKNLKTVNVPEDDGKKK
                     VDGIAYNVPGKAQVTLTEGKKQWFNGELPVTQFGTIEYLAPALFNKKSTVQVTFNPDTG
                     GLIKVDREEGE"
     CDS             complement(7246..7599)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg296_9"
                     /sec_met_domain="PF05402 (E-value: 1.8e-17, bitscore: 53.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 2.5e-10, bitscore:
                     29.8, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADVKEKINLLDVIPFRSENITAEKGSDGTVTIAFPRFKYEWMRR
                     FLLPKGMSADIHVRLEDHGTAVWELIDGKRTVRRIIEELAEHFNYEENYESRITAYITQ
                     LQKDGFVKLVIEN"
     CDS             complement(7606..8994)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 97.1; E-value: 1.4e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg296_10"
                     /transl_table=11
                     /translation="MTEQLKNKLSDSKTLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACILMVLGCGLKYY
                     AISTTFPEGALIMGFKTQVFLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPIADYFGYTDESGSFHTNIPMPILLCLIMLCIGTIAFFIYTF
                     YDKKLDASLDAQGEEPEEPFRMKDVMLIVTNKGFWLIALLCVLFYSAVFPFIKYATDLM
                     VQKYNVDPKLAGNIPGLLPIGTIFLTPLFGTLYDRIGKGATLMIIGAVMLIGVHTLFAL
                     PILNVWWFATVIMIVLGIAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFACFGVLALIVALMLKAEDKKKGYGLQEA
                     NIKK"
     CDS             complement(9165..9545)
                     /locus_tag="ctg296_11"
                     /transl_table=11
                     /translation="MYLLLVILMVIAAILMCFIVLIQNSKGGGLASGFSSSNQIMGVRK
                     TTDFLEKATWGLAAFMVVMSIATAYVVPTSSSKTQDVIMEQAQQEEQTNPYNLPVGTTA
                     PKTDAAAPVEAPATETPATPAN"
     CDS             complement(9550..9657)
                     /locus_tag="ctg296_12"
                     /transl_table=11
                     /translation="MEIIKKLSLKYPKKNAYFADQIRFLEKLIINAKSK"
ORIGIN
        1 aaccatttcg gtcaaaccat ctccataaaa aatattatca cctaaaacca aacagacaga
       61 atcatcccct ataaattttt ctcctatgat aaaagcttgt gccaaaccat caggtgaagg
      121 ttgctctgca tactcaaacc tcaccccaaa atcagatccg tcacccaata aacgttgaaa
      181 tcccggcaag tcatctggag tagaaataat gagaatttcc cgtatacctg ccaacattag
      241 tacagaaata ggataataaa tcataggttt atcaaagata ggaagcaact gcttactcac
      301 tcctttagtt ataggatata accgtgtccc cgacccacct gctaaaacaa tacctttcat
      361 tgtcagataa ctctctctat gtttttctta gcttctctta tcagttcctc atctcccgtc
      421 tgctcaaagc actccagcag caactgacat ttcaatacag aggctggtag tttttctaaa
      481 acagtcattg aacgatccaa taattcttga ataacctgtt cattctcaga ggagaaatta
      541 aacagcatgg tatcgtaacc tttgaacaaa gtaacaagta tttccgcctc ttcttcggga
      601 gattctcctt tctgaagaag aagatcggca cacaagttac ggagttcttg atttaacgca
      661 gtaagttcat tcacatagac aggagtaccg tcctcgccat actccaagag tttcttcact
      721 acggaggaca cagaattaca cagagaattt ttcattttaa aaaggaatga attatgattc
      781 gtcgattctt ttcggttttt atttgtatag aagagtaata atatccaata gaattatatc
      841 taacgacgta acggggcatt acatatattg ttatcacccg ttacatatat tgttatcgcc
      901 attacatata atggtatttt ctttacatat atacttttta tttctctttc cggacgtagc
      961 tagccggaat tgtaaccata gcgctaccga acatatcgat acgtactaaa atatgatatt
     1021 tattattata gcggaccaat tctccccgca agccttgtaa atcgcccttg gcaactacta
     1081 cacgagtacc tttgggaatg gactctcctg tcaggatcac ctgatcctgg gagtaatcga
     1141 gcatatagcg aaaatcagcc atttgcgcat cagggataca ggtaggagcc ccggtggaac
     1201 gatcacgaag gaaatcgtat acattcagtg tacttcggac ggcagccatt tcctgacggg
     1261 agatatgaac gaaaaccata cggggcaaca aaaggcgctc acgctcaatg cgttttcctt
     1321 cacgctctat gacacggttt tgtacaggaa gaaaggtatc tacctcctgc aattgaaaat
     1381 aatcccgaac tttacgttct gagttagttc gtgtcagtac gacataccaa tgtttatcgc
     1441 tatctgttgt ctccaagact acgttcgtaa gaaaaagttt cagcaatgac taaggatgaa
     1501 aatttgttaa aaacaggaat attcaaaaaa catgccttat tttcagcaat ttacaaatta
     1561 agttttatga taatcgggta cagaaaaagt attcgcaccg gatttgaata ctatccgata
     1621 cgttgaatta ttttatttta aacatatatc ggacataaag aaaagtatat ttgtccgcct
     1681 atatatttac gggtgcaaag gtaaaacctt cttttgagtc tccaaaactt ttcacaggtt
     1741 attttcatca taggaagtta tataactgaa tatcaaagat ataatttatc tctttgcaaa
     1801 taaggaaagc agcaatatac ataatactaa tgtggctcat aaaagaatgt ggaaataagt
     1861 ggagaggcag gctatggaga gtcttaacgg taacttgata aacagacaac tacgcacatc
     1921 ttgaatgtaa gagaagaatt ttacggcaga acgcatccag aatataagca attgattatc
     1981 aaacaataat atcttaataa gagaactgta ggaagttaac attaacagta cgttaatatt
     2041 aacttcgtaa ttgcaagata ttaattcttt agagatacga agttaataag ctattgataa
     2101 ggagggaaag cacttttacg ggcattaaca ttgttaacgt attcgttggt aagagcgtcc
     2161 cggcattggt tacaaccgca cagtttgccg atggcttacc aggcacagtt cttctttctt
     2221 cgtccggaat atggccgtat cggtaaaacc acttttggaa agaatcgcct tcagttcatc
     2281 acaggaatga atctccatcc cttcaacaag tcccgtccaa gccttattgg caggatcgct
     2341 tatctcacaa cagataagaa acgatccacc gggctttaac acacgcgcca cttccgtaaa
     2401 agcatgctgc aggttacccc agaagtagac agtctcgaaa gcagtgaccg catcgaacgc
     2461 ataatcagga tagggaagtc ggtggactcc tccctgctcg ataaagcagc gtgtaccgag
     2521 atacttttta ttttttttac gcgcaaaggt gacactctcc ggtgaaatat ctatgccata
     2581 cgctttccct tgcgggcaac gttgcaatat ctgtagcaaa ttggcaccac caccgcaacc
     2641 gatgtcgagt acactccatt ccggttgcca ttgcaagcat gacattcccc attgcgccaa
     2701 tgatgcatgt cctgtattca tcccccaaag tatcattctt ccgaaaaaac cttcaggctt
     2761 ccggaaattc tgtaagatcc tgcttacaaa gcctctctta ttcatttgtc tgctgattta
     2821 atatttcagg caaaagtaca gtttctgccc aaacaggcaa tacccagaaa tagggaattt
     2881 atttcctaaa agatatttgc aggtatgcat ctgcttcccg ttaaaattat gacgaacaga
     2941 tgcccggagg tgcgatgctc ttttcgtttt cgtttcataa atattacata aacattacaa
     3001 cataacagat tcattatcaa tatctattaa taataaacat tcatatattc agtaacaggt
     3061 ctgtaacact accctcctat ttttgcaccg gaaaacaaca agcagatgtt atgaacaatg
     3121 tacagcaagt aaaaacttat tcgcagagaa aaatttctga tttccttttc attctttggg
     3181 caggcggagc agcgctgctc tcctattcat tggtatatgc actgagaaag ccttatacag
     3241 cagccggatt tgacggactt gaagcgtttg gaatggacta caaagtggta gttaccatcg
     3301 cgcaaatatt aggatatgta ctttctaaat tcatcggaat taaattaatc tccgaattaa
     3361 aacgggaaaa ccggatgaag tttattctga tctccataat tctggctgaa gcttcgttaa
     3421 tattgttcgg actgttgccc gcaccttata atataggagc catgtttctg aacggacttt
     3481 cactgggatg tatgtgggga atcattttta gctttatcga gggaagacga atgacggaca
     3541 ttcttgccag cttactcgga gtcagtatgg tcatcagctc gggtaccgcc aagtcggccg
     3601 gtttgtatgt catggacact ttgaacatca gcgaattctg gatgcctgcc ctgataggcg
     3661 gagttgccct tcctctactt gccttgttgg gatatgcact caaccggctt ccacagccaa
     3721 cagccgaaga cattgccatg aaatcgaaac gggaaacact gaacggcaag caacgatggg
     3781 agctatttaa gaatttcatg cctttcctca ctctgctctt tatagccaat gtggtactga
     3841 ctatcttgag agatataaag gaggacttcc tggtaaaaat tatcgatgtc tctcaatact
     3901 cttcgtggat gtttgcacag gtagacagcg tagtaaccct cattattctg ataattttcg
     3961 gattaatggt gttcgtcaga agcaacttga aagcactgtc gatattactg ggattgatca
     4021 ttgccagcat ggtagtgatg gcagtcgttt cgtttggtta cgaacaattg cagctgaacg
     4081 ccatcgtctg gctattcatc cagagcctgt gtctctatct ggcttttctc actttccaga
     4141 ctatcttctt cgaccgtttt atcgcttgct tcaaaattcg aggtaacgtg ggtttcttca
     4201 ttgctatgaa tgattttctg ggctatacgg gaacagtcat agtattggct gtcaaagaat
     4261 tcttttcacc ggacattaac tggacagctt tctacaatct gatggcagga tatgtgggaa
     4321 taatctgttt cgttgctttt gtatgctctt tcatctacct gcaccaacgc taccgcaggg
     4381 agaattacgg aaagacaggg gtattcagaa aaaaagaaga agaaaaagaa gttcccgatt
     4441 tcgtatatta attgctatct ttgtgggtca aaaaacttaa aatgaaagtt caccatgaag
     4501 atttttccaa gtagcagcat caagaaactg gatgcttaca ccatagaaca tgaaccgatt
     4561 gcatcgatcg acctgatgga gcgggccgca caggcactga ccaaagccat caccgaacgc
     4621 tgggacatca caactcccgt cacggtattt gccggaccgg gcaacaatgg cggagatgcc
     4681 cttgccgtgg cccgaatgtt ggcggaaaag gaatacaagg tcgaagccta tctgtttaac
     4741 ccgaaagggg aactgtctgc cgactgccag accaacaagg agctggtaga gatgatggat
     4801 aatgtgaagt tcagcgaagt aagcacacag tttgtacctc ctgccctgac aatggatcat
     4861 ctggtagtgg acggactttt tggttcggga cttaataagc cgctaagtgg cggttttgcg
     4921 gcagtagtga aatatatcaa tgcatcgcct gccaccgtag tcgccatcga tatcccctcg
     4981 ggactgatgg gagaagagaa cacatttaat gtaaaagcca atatcatccg tgcccaattg
     5041 acattgagcc tgcaattgcc gaaactggct ttcctctttg ccgaaaattc cgaattcgta
     5101 ggcgaatgga aactgttgga tatcaacctc agtcgtgaag cgattgagga gacggaaagc
     5161 aattatgcct tattggaagc ggaagaaata cacgctctga tcaaaccccg taacactttc
     5221 tcacacaaag gaaactttgg gcatgctctg ctgattgccg gttcgtacgg catggcaggc
     5281 gcgtcgatac tggcagcccg cgcctgtatg cgttcgggtg taggcttact gacagtccat
     5341 gcacctatac gcaacaatga tatcctgcag atttcggttc cggaggcaat tatcgaatcg
     5401 gatgccagcg atacctactt tgcctgccct acagatacgg atgactatca ggctgtagga
     5461 atcggtccgg gcatcggacg ctcggaagag accgaagctg cactgcttga acaactcagt
     5521 ggttgccaga cacctctggt actggatgcc gatgcactaa acatattggc caaccaccgc
     5581 cacgcactga ccacattgcc caaaggctct attctgactc cccatcccaa agaactggaa
     5641 cgcatggtgg gcaaatgcca gaactcatac gaacgactga tgaaggcctg tgaactggcc
     5701 cgaaccgcca aagtacatat catattaaaa ggggcctatt cggcaattat caccccctcg
     5761 ggcaagtgct atttcaactc tacgggtaat ccgggtatgg caacagccgg aagcggagat
     5821 gtattgacag gtgtcgtgct ggctttgctc gcacagggat atccggctga agaagctgcc
     5881 aaaatcggta cttatgtaca tggcctggca ggtgatttcg cacgcaaaaa gcaaggcgtt
     5941 atcagcatga cggcaggaga cattatcagt aatctgccat tggcttggcg tctggtaagc
     6001 gaataaaagt taacaactta tgattttcca aataacttca ttaactttgt tttttaaacc
     6061 agttaaaata aaccggaaat gaaaaagcta attatactga cagggctgtt actctctacc
     6121 tcggcttatg cccagaccga agttacagcg ggagttaccc ggggaaaaga ttacggtgta
     6181 acctatgcac ttcctaaaac agcaatcaat attgaagtca aagtcaataa agtgacatat
     6241 actccgggag aattcagcaa gtatgccgac cgttatctcc ggttgaccga tgtgtcgggt
     6301 gagcctcagg aatattggga actggtcagc gtcaaagcaa aatctgtcgg tatccccgat
     6361 agcgaacata cctattttgt caagctgaaa gataaaactg tagctccgct aatagaattg
     6421 accgaagatg gtatcgtaaa atcaatcaac gtaccgctat ctcctaaaaa atcgactccg
     6481 atgcaacccg ccacgacaca gaaaaagaag ataaatccac gtgattttct gaccgaagag
     6541 attctgatgg caggttctac ggctaaaatg gcggagttgg ttgccaaaga gatttataac
     6601 attcgtgaaa gtaaaaatgc cctggtacgc ggacaggcag acaacatgcc caaagatggg
     6661 gagcaactga agattatgct tgccaacctg gaagagcaag aggctgccat gaccgaaatg
     6721 ttctcgggta ccttgaataa agatgaaaag atattcaaca tccgcctcac tccggataag
     6781 gaaatggaca acgaagtagc tttccgcttt tcgaagaagc tgggcatagt tgccaataac
     6841 gatcttgcag gagagccggt ttatatcacg ctgaagaatc tgaaaaccgt caacgtaccg
     6901 gaagacgatg gcaaaaagaa ggtggacggc attgcctata atgtgcccgg caaagcacaa
     6961 gtaacactaa cggaggggaa aaagcaatgg tttaacggag aacttcctgt cacacaattc
     7021 ggtaccatcg aatatctggc tccggcgctt ttcaataaga aatcgactgt tcaggttact
     7081 ttcaacccgg atacaggagg cttgatcaag gtagatagag aagaaggaga ataaaacata
     7141 atcaaaaact ccggccgatc ttaaatgaag tgcaccccaa aagttcatgt ttaactttta
     7201 gggtgcactt catttttaaa tcagccggag tctctttatt ataaatcagt tctcaatcac
     7261 taatttcaca aatccgtctt tctgcaactg agtgatataa gccgtaatac gtgattcgta
     7321 attttcttca taattgaagt gttctgccag ctcttcaata atccggcgta cggttctctt
     7381 tccgtcaatc aactcccata cggcagtgcc atgatcttcc agccggacat gaatatccgc
     7441 agacattcct ttaggcaaca agaatcgccg catccactcg tatttaaacc gggggaaagc
     7501 aatggtaacg gtaccatcgc ttcccttttc ggccgtaata ttttcactac ggaaaggaat
     7561 tacatccaga agatttattt tctctttcac gtctgccata tactgttatt ttttgatatt
     7621 tgcttcctgc agtccgtatc ccttcttctt gtcttccgct ttcagcatta aagctacaat
     7681 cagagccaaa acaccgaaac aagcaaagat agccataggc aaagtatagt cataagtctg
     7741 cgctccatcc acaacaggac ctttgcaata ggtattcaac acccatccga tcaacagagg
     7801 tacccccatc aatccccagt tctgcaccca gaaaatcaaa gcataggcag tacccagttg
     7861 tttctccgga ataattttcg gaacagaagg ccacatggcc gaaggcacca gtgaaaaagc
     7921 aatacccaga acaatcataa tcacagtggc aaaccaccat acgttcagaa tgggaagcgc
     7981 aaacaaagta tgcacaccaa tcagcatgac ggcaccgata atcatcaacg tcgctccctt
     8041 accgatacgg tcataaagag taccaaacaa cggagtcagg aagatggtac ctatcggtag
     8101 taatcccgga atatttccgg ccagcttagg gtctacatta tacttctgca ccatcaggtc
     8161 ggttgcatat ttaataaagg ggaaaacagc agaatagaat agtacacaca ataaagcaat
     8221 cagccagaag cctttattgg tgacaatcag cataacgtcc ttcatacgga acggttcttc
     8281 cggttcttct ccctgagcat ctaaagaagc gtcaagtttc ttatcataaa aggtataaat
     8341 gaaaaaggcg atagtaccga tgcacagcat gatcaggcac aacaaaatag gcatcggaat
     8401 attggtatgg aaactgccgc tttcatccgt atagccgaaa taatcggcaa tgggaacggt
     8461 aagcaccata gccaaagtgg taccgatacg tgcggttgcc atctcaagtc ccatagccaa
     8521 agccatctct ttacctttaa accatttcac gataatctta gagacagtga taccggcgat
     8581 ctctacgccg acaccaaaga tagcgtatcc taaagccgcc agaaagacct gagtcttgaa
     8641 acccataatc aaagctccct caggaaaagt agtagagata gcataatatt ttagtccaca
     8701 acccaacacc atcagtatac aagctcccat accggtgaaa cgaactccca tcttatcgag
     8761 aataatacca ccgaaaatca acatgagcag gaatacattg aaccatccgt aagcactggt
     8821 aaagaatccg tagtccaaac tatcccagag aagctctttc tcgagcatag gctttaaagg
     8881 ggacattaca tcggtgagga aatagccgca aagcatagta aacgcgacca gagcgagcac
     8941 actccaacga agtgttttgg agtcactcaa tttgtttttc aattgttctg tcattgtaat
     9001 atttaaactc agaaattagt aaaagtgtta ttgcgaacaa aggtaactaa atctgccttg
     9061 tatgcctaac aaaaagatgc attttacggc aaaaaataag cgaagctgca agtttcggtt
     9121 tgaaattgca gcttcgctta tcgtttctta aaaagaatct gttgttagtt tgccggagta
     9181 gccggagttt ctgtggcagg tgcttcaacc ggagcagcag cgtctgtctt cggtgcagta
     9241 gtacctacgg gcaggttata agggttggtc tgctcttcct gctgtgcctg ttccataatg
     9301 acatcttgtg ttttagaaga agaagtcgga acgacatacg cagtagcaat gctcatcaca
     9361 accataaatg cagctaagcc ccaagttgct ttttccagaa agtctgtagt tttgcgtaca
     9421 cccataatct ggttagatga tgagaaccct gaagcaagac caccgccttt tgagttctga
     9481 atcaacacaa tgaagcacat cagtatggct gcaataacca ttaagataac taataataag
     9541 tacattttgt tattttgatt tagcgttaat aatcaatttc tctaaaaatc tgatttggtc
     9601 tgcaaagtaa gcattttttt ttggatattt caagcttaat tttttaatta tttcaagag
//
