LOCUS       gnlProkkaPIKNMKDH_56    5690 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PIKNMKDH_56.
ACCESSION   gnlProkkaPIKNMKDH_56
VERSION     gnlProkkaPIKNMKDH_56
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 05:15:14
            Original ID  :: gnl|Prokka|PIKNMKDH_56
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 5690
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..5690
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1400:5689]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1401..5689
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..5690
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..5690
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             83..1387
                     /locus_tag="ctg56_1"
                     /transl_table=11
                     /translation="MIYMFTRMIRSLLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTA
                     AIYEGEILWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVAL
                     LGFALLPVPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKT
                     LGQFVMDNLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKD
                     RRKFLRQFFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAVFV
                     LVLMFLIVFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMG
                     YIPFTYLIERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRT
                     ALFSGFVSVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             1401..2099
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg56_2"
                     /sec_met_domain="NTP_transf_3 (E-value: 5.8e-15, bitscore:
                     44.4, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLSCGIERII
                     LGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDSFLLLESDLVFE
                     RKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKNALEAKGELVGIHK
                     LSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEIDDEADLS
                     YAEEHIIRYC"
     CDS             2119..3420
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.1;
                     E-value: 3.9e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg56_3"
                     /sec_met_domain="CTP_transf_like (E-value: 1.3e-13,
                     bitscore: 39.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 4.6e-123, bitscore:
                     398.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.3e-65, bitscore:
                     208.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIYVGMTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHK
                     RLPYLTYDQRKEVVENIKGVCEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVRE
                     QVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILE
                     AHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDS
                     IEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKD
                     KSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAM
                     MNVARTILENERAEEVRPLCMPIKEILELIPGTK"
     CDS             3432..4568
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg56_4"
                     /sec_met_domain="TPP_enzyme_N (E-value: 7.5e-23, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.5e-21, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             4565..5689
                     /NRPS_PKS="Domain: Aminotran_5 (30-301). E-value: 1.1e-33.
                     Score: 108.4. Matches aSDomain:
                     nrpspksdomains_ctg56_5_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 80.9; E-value:
                     1.5e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg56_5"
                     /sec_met_domain="Aminotran_5 (E-value: 7e-32, bitscore:
                     99.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIVGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMREAISFLKISFKNIV"
     aSDomain        4655..5467
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg56_5_Aminotran_5.1"
                     /evalue="1.10E-33"
                     /label="ctg56_5_Aminotran_5.1"
                     /locus_tag="ctg56_5"
                     /protein_end="301"
                     /protein_start="30"
                     /score="108.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIVGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIKREWQSGLV"
ORIGIN
        1 ttctgagtgt tttttattta gcgaatagaa tatttttaca ttcagccctg ttaaatcgta
       61 atttgaattg tcgttacatt ggatgattta tatgtttaca cgaatgattc gttcccttct
      121 ttcccgttct cccctttacg ttttggctct ctatgccagc gttttgattt ttctggttta
      181 tacctgtgcc tatgcctacc gtaagccatt taccgcagcc atttatgaag gtgagattct
      241 ttggggattc gatgtcaaaa tcctgtatgt cctttctgag attatcggct acgccctttc
      301 caagttcatc ggtgttcgta ttctgccttc gatgaaagcg ggtcaccgca tctattatat
      361 aatagggctg cttacttttt ccgaagttgc tttgttgggt tttgcacttc ttccggttcc
      421 tttgaaggtg tgttctattt ttctgagcgg tcttcccctg ggtatgatct ggggtgtcat
      481 ttttagctat atcgaagggc gtcgtatcag tgaaatattg aatgtcgggc tgagcgttgc
      541 tttgatagtc tcttccggtt tggtgaaaac cttgggacaa ttcgtgatgg ataatttgca
      601 tgtgtcggaa tattggatgc cttttaccac cggtttgttg gtataccctg ttatgttgct
      661 ttgcagctgg cttctcaatc agattccggc tcccaatgag caagatatca tacagcgtac
      721 caaacgtgct ccgatggatg gtaaagacag gcgtaaattt ttgaggcaat tcttctgggg
      781 aatctgcatg ctggttgttt tttacggtgc cctgaccgtg ttccgtgagc ttcgtgactc
      841 tttcgctgcc gatatttgga aggagctcca tattgaaggt gcaatgatct ttactcagac
      901 agaggttccc attgccgttt ttgtccttgt actgatgttc ctgattgtgt ttgtccgtaa
      961 taatcgtttg gctcttaata tcatttattg catcgccgtc acaggcggtt ccttaatggt
     1021 tttttccaca ttgctttatg tgtacggttt tctttctcct atttggtgga tgattctttc
     1081 cggtcttggt ctgtatatgg ggtatattcc tttcacttac ctgatagaac gtctgattgc
     1141 ttcccttagg gtggttagta cggctgtttt tattatttat ttggccgatt ctttcggcta
     1201 tctgggcact acgggtgtgt ttatggtcaa gaacttcgtt tctgctgaca tttcctggac
     1261 tgtcatgctg atgcgtactg cccttttttc aggatttgtt tctgtcctgt cgatttttgc
     1321 gatttactgt tatttcaagc aacaattgaa ttcacttata ttaattccct ctgaaattca
     1381 tgattaaaac agcaatgatc atggctgccg gtcttggtac ccgcttcggg cattataccg
     1441 agcttgtgcc caaaggtttt gtggaggttg gtggaaaacc tatgattatc cgctctatcg
     1501 aaacccttct ttcctgcggt atcgaacgta tcatcctcgg tacgggttat aaaaaagagg
     1561 cttatgaagc ccttcaggcg gatttccccc agatagagac ctgtttcagt ccccgttatg
     1621 ccgatactaa cagtatgtac actctgtaca atacgcgtga cgtgataggc gatgacagtt
     1681 tcctgctgct tgaatcggac cttgtttttg aacgcaaggc catcctttcg ctactggatg
     1741 acgaattccc ggatgtgatg cttgtctctt ctctgaccaa gttccaagat cagtattatg
     1801 tggaatatga ccgcaatcac atccttactt cctgttcggt agacaagaac gcccttgagg
     1861 caaaaggcga gctggtcggt atccataaac tttccaatac tttctaccgc cggatgtgcg
     1921 ccgattatgc gaccatcctg gagtcccagc ctaaactggg ttacgagtac gaactgctcc
     1981 gcatgtcccg ttccgtttcc cctgtccgtg tgctcagggt ggaggggctt aaatggtatg
     2041 aaatcgatga tgaagccgac ctttcgtatg ctgaggagca catcatccgc tattgttaaa
     2101 aacaaatctt ttccatatat gaacaagaaa atctatgtcg gtatgaccgc ggatatcatg
     2161 catccggggc tgatccatat tattcatgaa gctactaaat acggtgatgt catcgtcggt
     2221 ctgctgacgg acaaggccat cgccgaacac aaacgcctcc cttaccttac ctatgatcag
     2281 cgtaaggagg ttgttgagaa tatcaaaggg gtttgcgaag ttgttcccca ggaggattgg
     2341 agctatgttc cgaatctgga aaaactcaag cctgactata tcatccacgg tgacgactgg
     2401 aaaacgggtc cgttgcgcga ggtgcgcgaa caggtttttg aggtgatgaa cgcccagggg
     2461 ggcaaggtaa tcgagatccc ttatacccgg ggcatcaact cctcctcgct cgacaaggat
     2521 atcaaggcga tcgggactac ccctgacgta cgtcttaagt ccctccgccg cctgatccag
     2581 gccaagcctg tggtccgtat cctggaggct cacgacggtc tttgcggtct gattattgag
     2641 aatcttgaag tccagaaggg tgataagcgc gaggtctttg acggcatgtg gtccagcagc
     2701 ctgaccgact ctacgagtaa gggtaaaccg gatattgaag cggtcgacct taccacccgt
     2761 ttacaggacc tgaacaatat ccttgaatgt accaccaagc ctattatttt tgatggagac
     2821 acgggtggca agatcgaaca ctttgtcttt actgtgcgca ctctggaacg tcatggcatt
     2881 tctgcggtaa tcattgaaga taaagtcggt ctgaagaaga attccctttt tggtactgac
     2941 gctatccaga ctcaggatag tatcgagggt ttctgcgata agatcagagc agggaagaat
     3001 gcccaggtca ccggtgactt tatgatcatt gcgcgtatcg aaagccttat tgccggcaaa
     3061 cccatgagtg acgccctcga acgtgcttat gcctatgtac aggcgggtgc ggacggcatc
     3121 atgatccaca gcaaggataa gtcgggtgag gatatccgtg agttctgccg gactttccgc
     3181 aaagaatacg cccatgttcc cattgtcgtt gttccgacga cttatgacca tgtgcacgaa
     3241 tccgaacttc acgaatgggg tgccaacgta gtcatttacg ccaaccacct tctccgtgcc
     3301 gcttacccgg ccatgatgaa cgtggccagg accatccttg aaaacgagcg cgccgaggag
     3361 gtccgtccgc tttgtatgcc tatcaaggaa attctggaat tgattccggg cactaaataa
     3421 atcagacggt tatggtaagt gtagaaaaga tatacgatac gttccttcat cacggtgttg
     3481 acttctttac gggtgttccc gattcccttt tgaagaatat ttgcgcctat atcacggatc
     3541 atgctccgcg tggtaagcat atcatcgccg ccaatgaagg ttccgcggtg ggcattgcct
     3601 gcggttatta tatggcttcc ggcaacgttc ctttggttta tatgcagaac tccggtctgg
     3661 gaaatacggt gaatcccctc ttgtcccttg cggacgagaa agtgtacagc cttcctcttc
     3721 ttttgctggt cggctggcgc ggtgagcccg gcacgaaaga cgaaccccag cataagaagc
     3781 agggcgaggt tacccttgat cttctgaaag ccatgaaaat tccttttata attctggata
     3841 cggatgaaga cgaggccctg gcgcagatcc atgatgcggt tgtctcggcg aagagccggt
     3901 cgattcccca tgcgattgtc atccgtaaag atacgtttgg aaaatataaa ttgcgtcagg
     3961 aagccttgaa tgactatcct ctgtcccgtg aggaggcgct aatgcaggtt gtcgaccacc
     4021 tcggggacaa tgacattgtg gtttccacca cgggcaagct ctcccgtgag cttttcgagt
     4081 accgtgaatc gaaagggcag gggcacgcaa gggatttcct aactgtgggt tccatgggtc
     4141 acagttcttc cattgccctg gggattgccc ttgagaagcc tgaccgccgt gtctactgtc
     4201 ttgacggtga cggtgccttt atcatgcaca tgggtgctgt cagcaatatc ggcgatcttt
     4261 ctcccaagaa ttacaggcac gtccttttca acaacggtgc ccatgaatct gtcggcggtc
     4321 aacccacgct cggtttccgt ctggatatcg cctcgatagc gaaaggttgc ggttatgcgc
     4381 atgtactgac tgcctccgac aaggaagggc tttcgtgtgc gcttgagaag ctgtccggcc
     4441 tgtccggccc ggttcttctt gaaattaagg tccggatcga ttcacgtgat gatctgggtc
     4501 gccctacgac tactccggta gagaataaag agcattttat ggcattttta aaagatacgc
     4561 attcatgaat atcgaaagaa agatcctttt gaatccgggt cccgccacca cgacggatac
     4621 ggtgaagctg gcgcaggttg ttcccgatat ctgtccgcgt gagaaagagt ttgcgggtat
     4681 gatgaaacag ttacgtgacg acctggtccg cgttgcgcat ggagacctct ccaaacatac
     4741 ggccgtcctg ttttgcggct cgggtacgat caatatcgat atctgcctga actctcttct
     4801 tcctgcggat aagaaagttc tggttgtcaa taacggtgcc tacagcaccc gtgcggtgga
     4861 agtctgcgaa tattacggtc ttccccatat cgatttgaag ttttccgttt acgaacttcc
     4921 cgacctgtcg gtaatcgaaa agacgctttc cgacaatccg gacatcgctt tggtctatac
     4981 cacgcaccat gaaacgggta cgggtatctt gaaccccatc cgtgagatcg gaaaaatagc
     5041 ccattcgcac ggtgccgttt ttgttgtcga caccacttct tccctgggta tgattccttt
     5101 tgatatcggg aaggataatg ttgacttttg tatggcttcg gctcagaaag gccttcaggc
     5161 catgacgggt ctttccttta tcgtaggtga tgaatccctg atacgtgctt caagggatta
     5221 tccgaaacgt tcctactatt gtaacctcta tttacaatac gattactttg agaagacggg
     5281 tgagatgcat tttactcctc ctgttcaaac cgtttacgct gcccgtcagg ctcttgatga
     5341 atattttgca gtaggtgaag aggctaaatt cgcccgtcac aagagggtct ttgaagccat
     5401 ccataaaggt ttgcaagagc ttggtcttca gtatgcgatc aaacgtgaat ggcagtcggg
     5461 tcttgttgtt tctgtattgt atcctgatga tcccctctgg gattttgata aggttcatga
     5521 ttactgctat gaacgtggct ttacgatcta cccgggtaag atttccacaa cgaatacatt
     5581 ccggctttgt gcgttgggag agattgatgt ggaggatatt gagaggttct ttgaggtgat
     5641 gagggaagca atttcatttc tcaaaatcag ttttaaaaat atagtttaat
//
