LOCUS       c00180_gnlPro..        22769 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PIKNMKDH_180.
ACCESSION   c00180_gnlPro..
VERSION     c00180_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 10:30:43
            Original ID  :: gnl|Prokka|PIKNMKDH_180
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 22769
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..22769
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2832:12769]"
                     /cutoff="10000"
                     /detection_rule="(Oxidored_q4 and Oxidored_q6 and
                     Complex1_30kDa and Complex1_49kDa and NADHdh and
                     Oxidored_q3 and Oxidored_q2 and minimum(4, [Fe-2S_thioredx,
                     Fer2_4, Fer4_7, Molybdop_Fe4S4, Molydop_binding,
                     NADH-G_4Fe-4S_3, NADH_4Fe-4S, Proton_antipo_M,
                     Proton_antipo_N, SLBB]))"
                     /neighbourhood="10000"
                     /product="NADH_dehydrogenase_I"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2833..12769
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Oxidored_q4 and Oxidored_q6 and
                     Complex1_30kDa and Complex1_49kDa and NADHdh and
                     Oxidored_q3 and Oxidored_q2 and minimum(4, [Fe-2S_thioredx,
                     Fer2_4, Fer4_7, Molybdop_Fe4S4, Molydop_binding,
                     NADH-G_4Fe-4S_3, NADH_4Fe-4S, Proton_antipo_M,
                     Proton_antipo_N, SLBB]))"
                     /neighbourhood="10000"
                     /product="NADH_dehydrogenase_I"
                     /protocluster_number="1"
     cand_cluster    1..22769
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Oxidored_q4 and Oxidored_q6 and
                     Complex1_30kDa and Complex1_49kDa and NADHdh and
                     Oxidored_q3 and Oxidored_q2 and minimum(4, [Fe-2S_thioredx,
                     Fer2_4, Fer4_7, Molybdop_Fe4S4, Molydop_binding,
                     NADH-G_4Fe-4S_3, NADH_4Fe-4S, Proton_antipo_M,
                     Proton_antipo_N, SLBB]))"
                     /kind="single"
                     /product="NADH_dehydrogenase_I"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..22769
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NADH_dehydrogenase_I"
                     /region_number="1"
                     /rules="(Oxidored_q4 and Oxidored_q6 and Complex1_30kDa and
                     Complex1_49kDa and NADHdh and Oxidored_q3 and Oxidored_q2
                     and minimum(4, [Fe-2S_thioredx, Fer2_4, Fer4_7,
                     Molybdop_Fe4S4, Molydop_binding, NADH-G_4Fe-4S_3,
                     NADH_4Fe-4S, Proton_antipo_M, Proton_antipo_N, SLBB]))"
                     /tool="gutsmash"
     CDS             3..2732
                     /locus_tag="ctg180_1"
                     /transl_table=11
                     /translation="EADFTAGHYVCSEYLCDLLGLEGNTISFTDFRRRVREDYQEQIVR
                     EFNASIHREFYEQTFPIQSKEGIVWLHTRLGEREEIPGRGVVSFGIIQRVEAPNDTSER
                     VLERVNDLLYRQNSISHSLLRFLKDDSVDLCIMEILKDILDLFHGGRVYIFEYDEYYRY
                     QDCTYEVVAEGVLPEIDSLQRIPTDSLPWWRQQTLSGKPVILDSLDQLPKHAKAEYAIL
                     SRQNIKSLMITPLIAGEHVWGYMGIDLVKNYRNWNNEDFQWLSSLANIISICIELRKAK
                     DEAVRERSFLRNLFRFMPMGYIRMTMVRDAAGLPCDYRIADANDLSSELIGMSLSDYVG
                     CLASELHADFKAKVDYLLDVMEGSVHKETDVYFHRTQRSSHCIVYSPEKDEVVALFLDS
                     TETIRAHRALDRSEKLFKNIFANIPAGVEIYDKDGNLLDLNNWDMETFGVKDKADVMGV
                     NFFENPNVPLEIRERVRNEDLVDFRLNYSFNKASDYYHSDKSNIIELYTKVSKLFDSQG
                     NFNGYVLINIDNTERIDAINRIRDFENFFLLISDYAKVGYAKLNLLSKRGYAIKQWFKN
                     MGETEDIPLSSVVGIYDKMHPEDRQKVFDFYEKVLAGEEKDFRSEMRILKPGATNEWNW
                     VRMNVVVTKFEPEHGEVEIIGINYDITELKETEAMLIEAKEKAETMDRLKSAFLANMSH
                     EIRTPLNAIVGFSGLLVDTEDMEERCEYIKIVQENNDLLLQLISDILDLSKIEAGTFEF
                     TYGETDVNMLCEDIVRSSQIKVPQGVELVFDPHPSDCTVISDRNRLHQVISNFVNNALK
                     FTSSGSIHVGYEKKEEGVEFYVSDTGIGISKEQLTHIFERFVKLNSFIHGTGLGLSICK
                     SIVEQLGGVIGVDSEEGKGSRFWFTIPYINSEQSIVND"
     CDS             complement(2833..4284)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Proton_antipo_M"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg180_2"
                     /sec_met_domain="Proton_antipo_M (E-value: 8.9e-70,
                     bitscore: 226.3, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYSQFLYMKEELSLIAVILILFVVDLFTCPDQKGATPKVNVRSL
                     TLPAVILMTLHTVINLFPGTPAEAFGGMYQYTPMQTIIKAVLNVGTIIVLLMAHEWLKR
                     EDTRIKEGEFYVLTLSTLLGMYFMISAGHFLMFFIGLEMASIPMAALVAFDKYRHHSAE
                     AGAKYILTALFSSALLLFGLSMIYGTSGTLYFNDLPGHITGNMLQIMAFVFFFAGMGFK
                     ISLVPFHLWTADVYEGAPTAVTSYLSVISKGSAAFVLMTILMKVFAPMVAQWQEVLFWV
                     TIASITIANLFAIRQQNLKRFMAFSAISQAGYIMLGVIGGSEMGMTALVYYVLVYLAAN
                     LGVFAVISIVEQRSNKVEIDDYNGLYKTNPKLAFIMTLALFSLAGIPPFAGFFSKFFIF
                     MAAFNSGFHLLVFIALINTVVSLYYYLLIVKAMYINPNEEPIPTFRSDNYTKVSLALCT
                     LGIIALGIASCIYQGIDKFSFGMGM"
     CDS             complement(4291..5775)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Proton_antipo_M"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg180_3"
                     /sec_met_domain="Proton_antipo_M (E-value: 4.5e-67,
                     bitscore: 217.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFLSLFVLIPLLMLGGLYLAKSIKAIRGVMVAGSTALLILSVVL
                     TFLYLGERQAGATAEMLFRADTVWYAPLHIAYSVGVDGISVAMLLLSAVIVFTGTFASW
                     KLQPLTKEYFLWFTLLSMGVFGFFISIDLFTMFMFYEIALIPMYLLIGVWGSGRKEYAA
                     MKLTLMLMGGSAFLLIGILGIFFGAGGTTMNILEIAQLHNIPFAQQCIWFPLTFLGFGV
                     LGALFPFHTWSPDGHASAPTAVSMLHAGVLMKLGGYGCFRIAMYLMPEAANELGWIFLI
                     LTGISVVYGAFSACVQTDLKYINAYSSVSHCGLVLFAILMMNQTAATGAVLQMLSHGLM
                     TALFFALIGMIYGRTHTRDVRELNGLMKVMPFLSVCYVIAGLANLGLPGLSGFVAEMTI
                     FVGSFQNFDVFHRTLTIIACSSIVITAVYILRLVGKILYGTCTNKHHLALTDATWDERF
                     AVICLIICVAGLGMAPFWVSHMIGESVLPVVSHLIP"
     CDS             complement(5788..7698)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Proton_antipo_M"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Proton_antipo_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg180_4"
                     /sec_met_domain="Proton_antipo_N (E-value: 2.7e-25,
                     bitscore: 79.5, seeds: 433, tool: rule-based-clusters)"
                     /sec_met_domain="Proton_antipo_M (E-value: 1.8e-86,
                     bitscore: 281.0, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYTILILLLPFLSFLALGIGGKWMSHRTAGTIGTLVLAAVTVLS
                     YVTAVHYFSAPRLADGTFATLIPYNFEWLPFTETLTFNLGILLDPISVMMLIVISTVSL
                     MVHIYSFGYMKGERGFQRYYAFLSLFTMSMLGLVVATNIFQMYLFWELVGVSSYLLIGF
                     YYTRPAAIAASKKAFIVTRFADLGFLIGILIYGYYGGTFGFTPDTVSMLSGGAGMLPLA
                     LGLMFVGGAGKSAMFPLHIWLPDAMEGPTPVSALIHAATMVVAGVYLVARMFPLFIEYA
                     PDVLHLIGWVGAFTAFYAASVACVQSDIKRVLAFSTISQIGFMIVALGVCTSSDPHHGG
                     LGYMAGMFHLFTHAMFKALLFLGAGSIIHAVHSNEMSAMGGLRKYMPITHITFLIACLA
                     IAGIPPFSGFFSKDEILAACFQYSPTMGWVMTVIAAMTAFYMFRLYYGIFWGGTAPGQK
                     STSDGTSHVHTPHESPLTMTVPLIFLAAVTCVAGFIPFGHFISSNGESYTIHLETSVAV
                     TSVVIAVASIVLATCMYLRQQQPLADKLAKRFAGLHRAAYHRFYIDEVYQFITHRIIFR
                     CISTPIAWFDRHVVDGFFNFIAWGTHATSDEIRGLQSGRVQQYAYVFLLGALILILILI
                     L"
     CDS             complement(7735..8046)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Oxidored_q2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg180_5"
                     /sec_met_domain="Oxidored_q2 (E-value: 4.6e-22, bitscore:
                     68.9, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMIHMEYYLVVSTIMMFAGIYGFFTRRNTLAILISVELMLNATDI
                     NFAVFNRFLFPGELEGYFFALFSIAISAAETAIAIAIMINIYRNIRSIQVKNLDELKW"
     CDS             complement(8053..8565)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Oxidored_q3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg180_6"
                     /sec_met_domain="Oxidored_q3 (E-value: 1.2e-35, bitscore:
                     113.5, seeds: 708, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLTLETVVFYFLAVFIIAMSILTVTTQRIVRSATYLLFVLFGTA
                     GIYFLLGYTFLGSVQIMVYAGGIVVLYVFSILLTSGEGDRAAHLKRSKFLAGLVTTIIG
                     AILVLFITLTHKFVPTSDPEPVEISIKTIGHALLSSGKYGYVLPFEAVSILLLACIVGG
                     LLIARKR"
     CDS             complement(8572..9015)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1016:4Fe-4S dicluster domain (Score: 41.4; E-value:
                     5.5e-13)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg180_7"
                     /sec_met_domain="Fer4_7 (E-value: 3e-13, bitscore: 41.4,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.3e-05, bitscore: 16.0,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQGIGSLLTGMKTTIKVYFRKKVTEQYPENRAELKMFDRFRGTLN
                     MPHNENNEHRCVACGLCQMACPNDTIKVTSETIETEEGKKKKILAKYEYDLGSCIFCQL
                     CVNACPHDAITFDQVFEHAVFDRTKLVLQLNREGSKVIEKKKE"
     CDS             complement(9068..10090)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: NADHdh"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg180_8"
                     /sec_met_domain="NADHdh (E-value: 2.7e-121, bitscore:
                     395.6, seeds: 435, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEGLAVFIECVVIGVCIVALYAILAILLIYMERKVCGFFQCRLG
                     PNRVGKWGSIQVLCDVLKMLTKEIIELKHSDKFLYNLAPFMVIIASFLTFSCLPISKGL
                     EVLDFNVGVFFLLAASSIGVVGILLAGWGSNNKFSLIGAMRSGAQIISYELSVGLSILT
                     MVVLMGTMQFSEIVESQANGWFIFKGHIPALIAFVIYLIAGNAECNRGPFDLPEAESEL
                     TAGYHTEYSGMHFGFFYLAEYLNMFIVAAVAATIFLGGWMPLHIVGLDGFNAVMDYIPG
                     FIWFFGKAFFVVFLLMWIKWTFPRLRIDQILNLEWKYLVPISMVNLVIMVLIVVFGLHF
                     "
     CDS             complement(10224..11816)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Complex1_49kDa"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Complex1_30kDa"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg180_9"
                     /sec_met_domain="Complex1_30kDa (E-value: 4.1e-37,
                     bitscore: 118.7, seeds: 586, tool: rule-based-clusters)"
                     /sec_met_domain="Complex1_49kDa (E-value: 3.5e-64,
                     bitscore: 207.6, seeds: 265, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEIKYIEPAALHDEMLRLRNEKQMDFLESLTGMDWGVADEGDAP
                     NVTRGLGVVYHLESTVTGERIAIKTSTNNRETPEIPSVSDIWKAADFNEREVFDYYGIV
                     FIGHPDMRRLYLRNDWVGHPMRKDNNPEKDNPLRMDNEETYDTTREIELNPDGTYQTQE
                     NVIFDDREYVVNIGPQHPATHGVMRFRVSLEGETIKKLDANCGYIHRGIEKMNESLTYP
                     QTLALTDRLDYLGAHQNRHALCMCIEKAMGIEVSERVKYIRTIMDELQRIDSHLLFYSC
                     LAMDLGALTAFFYGFRDREMILDMFEETCGGRLIMNYNTIGGVQADLHPNFIPRVKKFI
                     PYLRGIIHEYHDVFTGNVIARQRLKGVGVLSREDAISFGCTGGTGRASGWACDVRKRMP
                     YGVYDKVDFKEIVYTEGDSFARYMVRMDEIMESLNIIEQLIDNIPEGPIQEKMKPIIRV
                     PEGSYYTAVEGSRGEFGVFLESHGDKTPYRLHYRSTGLPLVSAVDTICRGAKIADLIAI
                     GGTLDYVVPDIDR"
     CDS             complement(11838..12419)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Oxidored_q6"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg180_10"
                     /sec_met_domain="Oxidored_q6 (E-value: 6.7e-26, bitscore:
                     81.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKPKIKSIPYEDFIDNESLEKMVKELNEGGANVFVGVLDDLINW
                     GRSNSLWPLTFATSCCGIEFMALGAARYDMARFGFEVARASPRQADMIMVCGTITNKMA
                     PVLKRLYDQMADPKYVIAVGGCAVSGGPFRKSYHVVNGVDKILPVDVYIPGCPPRPEAF
                     YYGMMQLQRKVKIEKFFGGVNRKEKKPEGK"
     CDS             complement(12419..12769)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Oxidored_q4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg180_11"
                     /sec_met_domain="Oxidored_q4 (E-value: 1.6e-38, bitscore:
                     122.1, seeds: 391, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFTLLVVVLLTAIAFVGVVIALSNAISPRSYNAQKFEAYECGIP
                     TRGKSWMQFRVGYYLFAILFLMFDVETVFLFPWAVIARDLGPQGLISILFFLVVLVLGL
                     AYAWKKGALEWK"
     CDS             complement(12913..13290)
                     /locus_tag="ctg180_12"
                     /transl_table=11
                     /translation="MKQNLKYYIIIVLAVLLHSVTMKAANTSYIIEDPDQEECFISQAT
                     PASRNILERFHFYCTIMPCEMGHADISHVPTDKSFIRPEMIFHKYRMRNNPFSVHSNHS
                     HTYNPSDPLTYYVYGLRKIII"
     CDS             complement(13477..14928)
                     /locus_tag="ctg180_13"
                     /transl_table=11
                     /translation="MINSKMIYRITGFLLLIETGLLLCCAGVSLIYREDDLSSFLLSAG
                     LTTLVAILLLALGKGAEKQLNRRDGYVIVSVAWVVFSLFGMLPFYLSHYIPSITNAFFE
                     TMSGFSSTGATILDDIEALPHGLLFWRSMTQWIGGLGIVFFTIAVLPIFGVSGVQLFAA
                     EASGPTYDKVHPRIGVTAKWIWTIYAGLTAIEVILLLFGGMGLFDSICHSFATTGTGGY
                     STKQDSIAYYNSPYIEYVIGVFMFLSGINFTLLLLLFTGKLKKVSQNAELKWYVMSVIL
                     FTAFIAAVLYRTTPMGAEESFRKAFFQVASLHTSTGFVTADYMQWVPVLWGTLTVIMLI
                     GACAGSTTGGMKCIRMVILAKVSRNEFKHIVHPNAVLPVRVNKQVISPAILSTVLAFSF
                     IYAVIIIVSVLLMLAMGVGFTESIGTVISSIGNMGPGLGSCGPAYSWDGLPDLAKWLLS
                     FLMLLGRLELFTVLLLFSSDFWKRN"
     CDS             complement(14933..16138)
                     /locus_tag="ctg180_14"
                     /transl_table=11
                     /translation="MTVTASPSSISGLKEVGIKEADLFIAVTPDESRNMTACMLATNLG
                     AEKTVARIDNYEYLLPKNKEFFQKLGVDSLIYPEMLAAKEIVSSMRMSWVRQWWEFCGG
                     SLILIGTKMREKAEILNVTLAELGAPDIPYHVVAIKRGTETIIPRGDDTIKLHDIVYFT
                     TTRKYIPYIRKIAGKEEYADVRNVMIMGGSRIAVRTAQYVPDYMQVKIVDNDINRCNRL
                     TELLDDKTMIINGDGRDMDLLIEEGLKNTEAFVALTGNSETNILACLAAKRMGVSKTVA
                     EVENIDYIGMAESLDIGTVINKKMIAASHIYQMMLDADVSNVKCLTFANADVAEFTVPE
                     NAKITKNKVKDLGLPKGTTIGGLIRNGEGILVTGDTLIQAGDHVVVFCLSMMIKKIEKY
                     FN"
     CDS             complement(16312..18258)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transketolase_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transket_pyr"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg180_15"
                     /sec_met_domain="Transketolase_C (E-value: 3.4e-26,
                     bitscore: 82.8, seeds: 80, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2e-08, bitscore:
                     25.3, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Transket_pyr (E-value: 3.3e-34, bitscore:
                     109.3, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNEPTYSLLNAINYPKDLRQLSVDQLPEVCEELRQDIIKELSCN
                     PGHFAASLGVVELTVALHYVYNTPYDRIVWDVGHQAYGHKILTGRREAFSTNRKLGGIR
                     PFPSPEESEYDTFTCGHASNSISAALGMAVAAERKGEKDRHVVAVIGDGSMSGGLAFEG
                     LNNASSTANNLLIILNDNDMAIDRSVGGMKQYLFNLTTSNRYNQLRFKTSRLLFKMGLL
                     NEERRKALIRLGNSLKSLAAQQQNIFEGMNIRYFGPIDGHDVKNIARILHDIKDMQGPK
                     ILHLHTIKGKGFGPAEKQATIWHAPGKFDPVTGKRIVANTDGMPPLFQDVFGHTLVELA
                     EKNKRIMGVTPAMPSGCSMNMLMDRMPDRAFDVGIAEGHAVTFSGGMAKDGLLPFCNIY
                     SSFMQRAYDNIIHDVAIQKLNVVFCLDRAGLVGEDGPTHHGVFDMAYLRPIPNLTISSP
                     MDEHELRRLMYTAQLPDKGPFAIRYPRGRGSLVDWECPLEEIPVGKGRKLKDGNDLAVI
                     TIGPIGKLAARAIERAEADTGISVAHYDLRFLKPLDEELLHEVGKKFRHIVTIEDGIIK
                     GGMGCAILEFMADNGYYPEIRRIGVPDQFIEHGSVQQLYHLCGMDEEGIYKVITKNELR
                     MDAPVESCMATHS"
     CDS             complement(18757..20100)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hydrolase_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg180_16"
                     /sec_met_domain="Hydrolase_4 (E-value: 8.1e-18, bitscore:
                     55.6, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKKNLLKGICLLWLLLAVTPVLQAQDRAQQASELLDRLIAGQGD
                     SVYVHLDDNIRKMLSVEMLNGLFKQLEQQAGKYQSHGEWNTEPINGMTVYYCDVKFERL
                     PLRFLTAFNPDGKVNTIRFVPVPPEKTTPPTTSVQDKIKETDIQVCTGNFKLPGTLTLP
                     KNGKDLPVVILVHGSGASDRDETVGANKPFRDLAYGLAERGIAVIRYDKRTKVYGADSA
                     PAGKEITFDEESVDDALSAIKLARSIPTINPERIYILGHSLGGTLAPRIVQRSDKVPAG
                     IILLAGAARPLEDLFISQVKFLASALPSAKDIEKEIAELQKQVDNVKRLGTDTFDITTP
                     LPMNLSQAYWMLANQYKPLEVVRKLTLPILVLQGERDYQVTMQDFELWQSALAKHPNAI
                     FKSYPRLNHLFQEGEGKSTPLEYSRPSSIPSYVTDDIAAFINRPKPGN"
     CDS             20599..21246
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg180_17"
                     /sec_met_domain="HAD_2 (E-value: 9.3e-40, bitscore: 127.7,
                     seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLIIFDLDGTLLNTIADLAHSTNHALQTLGYPTHEVASYNFMV
                     GNGINKLFERALPEGEKTEENVLRVRKEFLLHYDRHNADESRPYPGIPELLETLQHKGY
                     KLAVASNKYQAATEKLIAHYFPGIRFVAVFGQREGVKVKPDPAVVHDILQIAGVSKDEV
                     LYVGDSGVDMQTAINSGVTSCGVTWGFRPRTELESFCPDYIVDKAETILSIV"
ORIGIN
        1 gggaagctga tttcacagcc gggcattatg tatgctcaga atacctctgc gatttattgg
       61 gacttgaagg aaataccata tcttttacgg acttcaggag acgggtacgt gaggattatc
      121 aggaacagat agtccgggag ttcaatgctt ccatccatag ggagttttat gaacagactt
      181 tccccattca atccaaagag ggaatcgtgt ggttgcacac ccgtttggga gaacgtgaag
      241 aaataccggg caggggagtc gtttcattcg gcatcataca gcgggtagaa gctcccaatg
      301 atacttccga acgggttctg gaacgtgtca acgacttgct gtacaggcag aactccattt
      361 cccattcact cttacgcttt ctcaaagatg atagtgtgga cctctgtatc atggaaatat
      421 tgaaggatat cctcgatctt tttcatgggg gacgcgtgta tatctttgaa tatgatgaat
      481 attaccgcta tcaggactgt acctacgagg tggtggccga aggagtgttg ccggagatcg
      541 atagcctgca acgtatcccg actgacagtt taccttggtg gaggcagcag accctgtcgg
      601 gcaaaccggt gatactggat tcattggacc agcttccgaa acatgcaaaa gcggaatatg
      661 cgatcctgag ccgccagaac atcaagtcac tgatgatcac tccgctgata gccggcgaac
      721 atgtatgggg gtatatgggg atcgatctgg tgaagaatta tcgcaactgg aataatgaag
      781 acttccaatg gttatcgtct cttgccaata tcatcagcat ctgtatcgag ctgcgtaaag
      841 cgaaagacga agctgtgcgc gaacgttctt ttttgcgtaa tctgttccgc ttcatgccga
      901 tggggtatat acgtatgact atggtccggg atgctgccgg actaccttgt gattaccgga
      961 tagccgatgc caatgatttg agttcggaac tcataggaat gtctctttcc gattacgtgg
     1021 gatgccttgc cagcgagttg catgcggact ttaaggccaa ggtggattat cttctcgatg
     1081 tgatggaggg cagtgtgcac aaagagactg atgtctactt ccatcgcacc cagcgcagtt
     1141 cccattgcat cgtgtattct ccggaaaaag acgaggtggt cgctctgttt ctggactcta
     1201 ccgagacgat tcgtgcccat agggctttag atcgcagtga gaagcttttc aagaatatct
     1261 ttgccaatat tcccgcggga gtggagattt acgataagga tggcaatttg ctcgacttga
     1321 acaactggga tatggaaacc tttggtgtaa aagataaagc cgatgtaatg ggagtcaact
     1381 tctttgagaa tccgaatgtg cctcttgaaa tcagagaacg ggtacggaac gaagacctgg
     1441 tcgatttcag actgaactac tcttttaata aggcttccga ttactaccat tccgataaaa
     1501 gtaatataat cgagctgtat acaaaggtca gtaaactctt tgacagccaa gggaacttca
     1561 acggctatgt gctgatcaac atcgataata cggagcgtat cgatgccatt aaccgtatcc
     1621 gtgattttga gaacttcttc cttttgatat cggactatgc aaaagtaggt tatgccaaac
     1681 tgaacctgct gagtaaacgc ggctatgcca tcaaacagtg gtttaagaat atgggtgaga
     1741 cggaggatat tccgctttca tccgttgtgg gcatttatga taagatgcat cctgaagacc
     1801 ggcagaaggt ctttgacttt tacgagaagg tattggcggg tgaagagaag gacttccgta
     1861 gcgaaatgcg tatcctgaaa cccggcgcta ccaacgagtg gaactgggta cggatgaatg
     1921 tggtagtgac caagtttgaa ccggagcatg gggaggtgga gattatcggc attaattatg
     1981 atattacgga actgaaagag acggaagcca tgcttatcga ggcgaaagag aaagcggaaa
     2041 ccatggaccg gctgaagagc gctttcctgg cgaatatgag tcacgagata cgtacaccac
     2101 tcaatgcgat tgtcggtttc tcgggcctct tggtcgatac ggaagacatg gaggaacgct
     2161 gcgaatacat caagatcgta caagagaata atgacttgct gctgcagctg atctcggaca
     2221 tcctggactt atcgaagatt gaggccggta cgtttgagtt cacctacggg gagacggatg
     2281 tgaatatgct ttgtgaagat atcgttcgca gctctcagat aaaggttccc cagggagttg
     2341 aattagtatt cgatccgcat ccttcggatt gcactgtgat aagtgatcgg aaccggttgc
     2401 atcaggtcat ctccaatttc gtgaacaatg ccctgaagtt tacctcctcg ggcagcatcc
     2461 atgtgggata tgaaaagaag gaagagggtg tggagtttta tgtaagcgac acgggaatcg
     2521 gaatctctaa agagcaactg acgcatatct ttgaacgctt tgtgaagctg aacagcttta
     2581 tccacggaac cgggctcgga ctctccatct gtaaaagtat tgtggagcag ctgggcggcg
     2641 tcataggagt ggactcggaa gaagggaaag ggtcccgttt ctggttcacc attccctata
     2701 ttaacagcga acagtcaatc gttaacgatt gatagacggt ccggctataa acaacaaacg
     2761 gtgaacaaca catactatat tgtatgcctg ttcaccgttt gttgtttata gctgatcgtt
     2821 taccgttgat ctttacattc ccattccgaa tgagaacttg tcaattccct gatagatgca
     2881 acttgcaata cccagagcta tgatacccaa agtacaaagt gcgagactca ctttggtgta
     2941 gttatcactg cggaaagtgg ggatcggttc ttcattggga ttgatataca tggcctttac
     3001 aatcagtaag tagtagtaaa gcgatacgac tgtattgatc agggcaatga ataccaatag
     3061 atggaatccg ctgttgaatg cagccatgaa aatgaagaac tttgagaaga aacccgcaaa
     3121 cggagggata ccggccagtg agaacagggc aagggtcatg ataaaagcca gtttgggatt
     3181 ggtcttgtac agtccgttat agtcgtctat ctccactttg ttgctacgtt gttccacaat
     3241 tgagatgact gcaaatacac ctaagtttgc tgccagataa accagtacat aataaaccag
     3301 ggcagtcatt cccatttcac tgcctccgat gacacccagc atgatgtatc ccgcttggga
     3361 gatagcggag aatgccatga aacgtttcag gttctgttgg cggatagcaa agaggttggc
     3421 aatggtgatg gaagcaatgg ttacccagaa caacacttcc tgccattgtg ccaccatcgg
     3481 tgcgaacact ttcatcagga tggtcatcag cacgaaagct gccgatcctt tggaaatcac
     3541 acttaaataa gaggttacgg ctgtaggcgc tccttcgtat acgtcggctg tccagaggtg
     3601 gaaaggaacc aatgagattt tgaatcccat gccggcaaaa aagaacacga atgccataat
     3661 ctgaagcata ttgcctgtga tgtgtccggg gaggtcattg aaatagagcg taccggacgt
     3721 accgtatatc attgaaagac cgaatagcag caatgcactt gagaacagtg cggtcaggat
     3781 gtacttggca cctgcttctg cggagtgatg acgatattta tcgaatgcca ccagtgcggc
     3841 catcgggata cttgccattt ccaatccgat gaagaacatc aggaaatgtc ccgcagaaat
     3901 cataaagtac atacccagca gggtagagag tgtcagtaca tagaactctc cctccttgat
     3961 gcgggtgtct tcgcgtttca accattcatg ggccatcagt agcacgatga tggtacctac
     4021 gttgagcact gccttgatga tggtttgcat cggtgtgtac tgatacattc cgccgaaagc
     4081 ctctgccgga gttccgggaa agaggttgat tacggtgtgg agggtcatca ggatcacagc
     4141 cggcaaggtg agcgacctga cgttcacctt aggagtggca cctttttggt ccggacaggt
     4201 aaacaggtcg acaacaaaca ggatgaggat aactgctatc agtgacagct cctctttcat
     4261 atatagaaat tgtgaataat ccatcttctt ttagggtatt aagtgtgaaa caacgggcaa
     4321 tacactctcg ccaatcatgt ggctgaccca gaaaggagcc atacccagtc cggcgacaca
     4381 aatgatgaga cagatgacgg caaagcgctc gtcccaggtt gcatccgtca gtgccagatg
     4441 atgtttgttg gtacacgttc catatagaat cttacctacc agtcggagga tatagactgc
     4501 cgtgatcacg atggacgagc aagcgatgat ggtcagtgta cgatggaata catcgaagtt
     4561 ctggaatgaa ccgacgaaga tagtcatctc ggctacgaag ccgctaagtc ccggaagacc
     4621 caggttggca agtccggcaa tcacatagca gacactgaga aacggcatca ctttcatcag
     4681 tccgttcagc tcgcgtacgt cacgggtatg ggtacgtccg tatatcatac cgatgagggc
     4741 gaagaacaga gctgtcatta atccgtggct gagcatctga agcaccgctc cggtagctgc
     4801 tgtctggttc atcatcagga tagcgaagag cacaaggccg cagtggctta cggaagagta
     4861 tgcgttgatg tacttcaggt ctgtctgtac gcaagcactg aaagcaccgt atacaacgga
     4921 gatacctgtc aggatcagga agatccagcc cagttcgttt gcagcttccg gcatcaggta
     4981 catggcgatg cggaaacaac cgtagcctcc gagcttcatc aatacgccgg catgcagcat
     5041 agagacagca gtcggtgccg aggcatgacc gtcaggactc caggtatgga agggaaagag
     5101 tgctcccagc acaccgaatc ccaggaaagt gagcggaaac cagatgcatt gctgcgcaaa
     5161 cggaatgtta tgcagttgag ctatttcaag aatgttcatg gttgttccgc cggcaccgaa
     5221 gaagataccc agaataccga tcagcaagaa tgctgaacca cccattagca tcagggtcag
     5281 cttcatggct gcatattctt tgcgtcccga accccataca ccgatgagta agtacatcgg
     5341 tatcaatgcg atttcgtaga acatgaacat ggtgaataag tcgatggaga taaagaaacc
     5401 gaatactccc atcgacagga gggtgaacca caggaaatat tcttttgtca gcggctgcaa
     5461 cttccaggag gcaaaggtgc cggtgaacac gatgacagcg ctaagcagca gcatcgctac
     5521 cgatattccg tctactccca ccgagtaggc tatgtgaagc ggtgcatacc ataccgtatc
     5581 ggcacggaac aacatctcgg ctgtagctcc tgcctggcgc tcgcccaaat aaaggaacgt
     5641 cagcacaaca ctcaggatca gcaacgccgt acttcccgct accatcactc cgcggatggc
     5701 cttaatgctt ttggcaaggt ataacccgcc aagcatcagc agaggaatga gtacgaataa
     5761 ggataaaaag ttcatatctt ttgtgcttta taagattaat attaagataa gtatcagcgc
     5821 tccgagcagg aatacataag cgtattgctg tacacgtccg ctttgcaatc cccgtatctc
     5881 atcgcttgta gcatgggtac cccaggctat gaagttgaag aatccgtcta ccacgtggcg
     5941 gtcgaaccag gcgatcggtg tagagatgca acggaagata atccggtgtg tgatgaactg
     6001 atacacctcg tcgatgtaga aacgatgata ggctgcacgg tgcagtccgg caaaacgttt
     6061 ggcaagttta tctgccagag gttgctgctg acgcaggtac atgcaagtgg ccaggacgat
     6121 ggacgccaca gcaatcacta cacttgtgac ggctactgat gtctcaagat ggatggtata
     6181 cgattcaccg ttggagctga tgaaatgtcc gaaaggaatg aaaccggcca cgcaagtgac
     6241 ggcggccagg aagattaacg gaacagtcat ggtcagggga gattcgtggg gagtatgtac
     6301 gtggcttgta ccatcgcttg tcgacttttg ccccggtgct gtgccacccc agaagatgcc
     6361 gtagtagaga cggaacatat aaaaggcggt catagctgcg atgacggtca tcacccaacc
     6421 catcgtcggg ctatactgga agcaagctgc cagaatttca tctttggaga agaaacccga
     6481 gaacggagga atacctgcaa tggcgagaca agctatcagg aaggtgatat gcgtgatcgg
     6541 catgtatttg cgtaatcctc ccatagccga catctcgttg gagtgaacgg catggataat
     6601 gctgcctgca cccaggaaga gcaaggcctt gaacatggcg tgtgtgaaaa ggtggaacat
     6661 gccggccatg tatcccaacc ctccgtgatg cggatcggaa gaggtacaaa cacccagtgc
     6721 cacgatcata aatccgattt gtgagatggt cgagaaagca agtacacgct tgatgtcact
     6781 ctgtacgcaa gccacgctgg cagcataaaa agcggtgaaa gcacctaccc aaccaatcag
     6841 gtggagtacg tccggagcat attcgatgaa aagcgggaac atgcgtgcca ccaggtaaac
     6901 gccggctact accatggtgg cggcatgaat cagtgcactg acgggagtcg gaccttccat
     6961 ggcgtccggt aaccagatat gcaacgggaa catggcactc ttgccggcac cgccgacaaa
     7021 catcagcccg agtgccagag gtaacatacc ggcgccaccg ctcaacattg aaactgtgtc
     7081 gggagtaaat ccgaaagtac ctccgtagta tccgtatatc aggataccga tcaggaagcc
     7141 caggtcggca aagcgagtca cgatgaatgc ttttttactg gcggcaatag cagccggacg
     7201 ggtatagtag aaaccgatca ggaggtaaga agatacacct accaactccc agaataagta
     7261 catctggaaa atgttggttg ccactaccag tccgagcata gacatggtga ataaggataa
     7321 gaatgcgtag tagcgctgga atccccgttc gcctttcata tagccgaaag agtagatatg
     7381 taccatcagg ctgactgtag aaattacaat cagcatcatc accgagatgg ggtcgagcaa
     7441 aatgcccagg ttgaacgtta gtgtttccgt gaacggaagc cattcaaagt tataaggaat
     7501 gagtgtggca aacgttccgt ctgccagacg gggtgccgag aagtaatgta cggccgtgac
     7561 gtacgagagt actgtcactg ctgccaatac cagcgtgcct atggtgcccg ctgttcggtg
     7621 gctcatccac ttgcctccta tccctaatgc caggaaggag aggaagggga gaagaaggat
     7681 cagaattgta tattccataa tttagttatt atttctatga tcataatgac gtatttacca
     7741 ctttaattca tccagattct ttacctgaat actacgtata ttccggtaaa tattaatcat
     7801 gatggcgata gcgatagccg tttccgctgc cgagatggca atggagaaca gggcaaagaa
     7861 atacccttcg agctctccgg gaaaaaggaa acggttaaat acggcaaagt tgatatctgt
     7921 agcattcagc atcagttcta cagagatgag gatagcaagt gtgttgcggc gggtgaagaa
     7981 cccgtatatt cccgcaaaca tcatgatggt agaaaccacc aggtaatatt ccatgtgtat
     8041 catcatatcg tcctatcttt tacgtgcaat taataatccg cccacgatac aggccagcaa
     8101 cagaatgctg actgcttcaa aaggcaatac atatccatat ttaccactgc ttaacaaagc
     8161 atgtccgatg gtcttgatac tgatttctac aggttccgga tcgcttgtcg gcacaaattt
     8221 gtgtgtcagt gtaatgaaga gcaccaggat tgcacctata atcgtagtga caagccctgc
     8281 caggaattta ctccgtttca ggtgagcggc ccggtcgcct tctccactcg tcagcaggat
     8341 ggagaataca tagagcacca cgatacctcc ggcatagacc atgatctgta ccgatccgag
     8401 gaaagtgtat cctaacagaa agtagatacc tgctgtgccg aaaagcacga acagcaggta
     8461 agtggccgaa cgcacgatac gctgcgtggt cactgtcagt atggacatgg caatgatgaa
     8521 cactgccaga aagtagaata ctactgtttc aagtgtaagt cccatattct tttattcttt
     8581 tttcttttcg attactttac ttccttcgcg gttgagttgc aggacaagtt tggtccggtc
     8641 gaatacggca tgctcaaata cctggtcgaa ggtgattgcg tcgtgtgggc aagcgttgac
     8701 acagagctgg cagaagatac acgaaccaag gtcgtattca tactttgcca gtattttctt
     8761 ctttttgccc tcttcggttt caatggtttc gctggtcact ttaatggtat cattggggca
     8821 tgccatctga cacaacccac aggctacaca acggtgctca ttgttttcgt tgtgaggcat
     8881 gttcaatgta ccgcgaaagc ggtcgaacat tttgagttcg gcgcggttct ccgggtattg
     8941 ttcggtcact ttctttcgaa aatatacctt gatggtggtt ttcatacccg tcagcaggga
     9001 gccgatgcct tgcatcaggc cgcctagata tgtatattct tcatttttca tctttcagcc
     9061 ctccgggtta gaagtgcagt ccgaagacta cgattaatac catgattacc agattgacca
     9121 ttgaaatagg taccaaatat ttccattcca ggtttagtat ctggtcaata cgcagacgcg
     9181 ggaaagtcca tttgatccac atcagcagga acactacgaa gaatgccttt ccgaaaaacc
     9241 agatgaatcc cggaatataa tccatcactg cattgaatcc gtccagcccg acaatgtgca
     9301 gcggcatcca gcctcccagg aagatggtgg cggctacggc agctacgatg aacatattca
     9361 gatattcggc cagataaaag aagccgaagt gcatacccga atactcggta tggtatcctg
     9421 ccgtcagttc actttccgct tcgggaaggt cgaacggacc acggttacat tctgcgttgc
     9481 cggctatcag atagataacg aaagcgatca gggccgggat gtgtcctttg aagataaacc
     9541 atccgttagc ctgactttcc acaatctcag agaactgcat ggtacccatc aggaccacca
     9601 ttgtgagaat actaagtccg acagacaatt cataactgat gatttgtgca ccgcttcgca
     9661 tagcaccgat cagtgagaac ttattgttcg aaccccagcc ggccagcagg atacccacta
     9721 cgcctatgct cgaagctgcc aacaggaaga agacacctac gttgaagtcc agcacttcca
     9781 gccctttact gataggcagg cacgaaaagg tgagaaatga ggcgataatc accatgaacg
     9841 gagccaggtt ataaaggaat ttgtccgaat gcttcagttc gatgatctct ttggtcagca
     9901 tcttgagcac atcgcagagc acctggatgc ttccccactt tcctacgcgg ttcggaccca
     9961 gtcggcactg gaagaaaccg cacaccttgc gttccatata aataaggaga atggcaagta
    10021 tggcgtacaa agccacaatg cacaccccga taacgacaca ttctatgaat acagccaatc
    10081 cctccggcat gacggaggtt aatgtctggt gtatccaact tgttattata ctaaagtcaa
    10141 acatatacta tatttacgat tagacgattt actatttacg attggagtga tccggattta
    10201 ggataagagc cgtcagggct tccttatctg tcgatgtccg gtaccacata atccagcgtt
    10261 ccgccgatag cgatcaggtc ggcaatctta gctccccggc agatggtatc gacagccgaa
    10321 accagtggca accccgtcga acggtagtgc aaacggtaag gtgtcttgtc gccatgactc
    10381 tcgaggaaca ctccgaattc accgcggctg ccttcaacgg cggtatagta acttccttcc
    10441 ggtacccgga tgatgggttt cattttttcc tgtatcggtc cttccggaat attgtcaatc
    10501 aattgctcga taatgttcag gctctccatg atttcgtcca tacgcaccat gtaacgggca
    10561 aaagagtcgc cttcggtata aacgatttct ttaaaatcca ccttatcgta tacgccgtaa
    10621 ggcatacgtt tgcgtacatc acatgcccag ccgctggcac ggcctgttcc accggtacat
    10681 ccgaaagaaa tggcatcttc gcgactcagc acccctacac ctttcagacg ttgccgggca
    10741 atgacattgc cggtgaatac gtcgtgatat tcgtggatga ttccacgcag gtaagggatg
    10801 aacttcttta ctctcgggat gaagttcggg tgcaggtctg cctgtacgcc tccaatggta
    10861 ttgtagttca ttatcaaacg tccgccgcaa gtttcttcga acatatccag aatcatttca
    10921 cggtcacgga atccgtaaaa gaaggctgtc aatgcgccta ggtccatggc aagacaggag
    10981 tagaatagga ggtgagagtc gatacgctga agttcgtcca tgatagtacg gatgtatttc
    11041 acgcgttcac tgacctcgat acccattgct ttctcgatgc acatgcagag tgcatggcgg
    11101 ttctggtgtg ctcccagata atcgagccgg tcggtcagtg ccaaagtctg cggataggtg
    11161 aggctttcgt tcatcttctc gatcccacgg tgtatatatc cgcagttggc gtcgagcttt
    11221 ttgatggttt cgccttcaag tgagacgcgg aagcgcatca ccccgtgggt tgccgggtgc
    11281 tgtggcccga tgttgactac gtattcacgg tcatcgaaga tcacattctc ctgagtttga
    11341 tacgttccgt ccggattcag ctctatttcc cgggtcgtat catacgtctc ttcattgtcc
    11401 atacgtaacg gattgtcttt ctccgggttg ttatctttac gcatcggatg gcctacccag
    11461 tcattacgca gataaagacg tcgcatgtcg ggatgtccga tgaatacaat gccgtaatag
    11521 tcgaaaactt cacgctcgtt gaagtcggcc gctttccaga tgtcactgac ggaaggtatt
    11581 tccggagttt cgcggttatt tgtggatgtt tttatcgcga tgcgttcgcc ggttacggtc
    11641 gattccagat gatagactac tccaagtccc cgggttacgt tcggtgcgtc accttcgtct
    11701 gccactcccc agtccatacc cgttaggctt tcgaggaagt ccatctgttt ttcgttacgc
    11761 agacgcagca tttcgtcatg tagtgctgcg ggttctatgt attttatttc ttccatattt
    11821 tactaattaa agcagattca tttcccttca ggttttttct ctttccggtt tactcctccg
    11881 aagaatttct ctatcttcac tttccgttgc agttgcatca taccgtaata aaatgcttcc
    11941 gggcggggag ggcatccggg aatatataca tcgaccggga gaatcttgtc tactccgttc
    12001 accacatgat aggatttgcg aaacgggcct ccgcttactg cacatcctcc tacggcaatt
    12061 acatatttgg gatctgccat ctgatcatac agacgtttca gtaccggagc cattttgttg
    12121 gtaatggtgc cgcataccat gatcatgtcg gcttggcgcg gactggcacg ggctacttca
    12181 aacccgaagc gggccatgtc gtaacgcgcg gcacccagtg ccatgaattc gataccgcaa
    12241 cagctggttg cgaaagtaag tggccacagc gagttgctgc gtccccagtt gataagatcg
    12301 tcaagtactc ccacaaagac gtttgcaccg ccttcattga gttctttgac catcttttcc
    12361 aacgattcgt tgtcgatgaa gtcttcatac gggatagact ttattttagg ctttttcatt
    12421 atttccattc cagtgctcct ttcttccagg cataggcaag gcccagaacc aacacaacta
    12481 aaaagaagag aatactaatc aatccctgag gtcccaggtc acgggctatg acggcccagg
    12541 gaaacagaaa tactgtttcg acatcgaaca tcagaaacag aatggcaaac aggtagtatc
    12601 ctacacggaa ctgcatccat gatttaccgc gcgtagggat accacattca tacgcttcga
    12661 acttttgtgc attatacgac cgcggcgaga tagcgtttga aagggctatc accacaccga
    12721 caaaggcaat tgcggtcagc agaacgacaa ctaacaatgt aaaattcata atccaatagt
    12781 atgtttagat tgaataatct gaagtaagca ataagttgac acacctctga gtgacaactg
    12841 attgaaagag tattgacagc tatcagtgaa acagtttaca tgatagcatg gctactcgtg
    12901 gcttgtgact ctttaaatga tgattttcct taatccgtag acatagtagg tcagtggatc
    12961 agacggattg tatgtatgtg agtgatttga atggacagaa aaaggattat ttctcattct
    13021 gtatttatga aagatcattt caggacggat aaaacttttg tccgttggta catgagaaat
    13081 atctgcatgc cccatttcac agggcataat ggtacaatag aaatgaaagc gttccaggat
    13141 attccggctt gcaggagtag cttgcgaaat gaaacattct tcctggtccg gatcttctat
    13201 tatataagag gtgtttgccg ctttcatcgt taccgaatga agcagcacgg caagcactat
    13261 tattatataa tattttaagt tttgtttcat tcctatttct taaacggttg caaatataga
    13321 atttaatttt atctcttttg caaactccac gtgacaaaaa aggtttttta ataaatcaag
    13381 ggagtcagaa gttggaggga ttatcaaccg atttctgacc cgcctctact atatattatc
    13441 ttgtatgata caacaatgaa gcttctctac ttgtttctaa ttccttttcc aaaagtcaga
    13501 actgaataaa agtaagacgg tgaatagttc cagacgtccc agtaacatca ggaacgacaa
    13561 taaccatttg gccagatcag ggagtccgtc ccatgaatag gccggaccgc agctccccaa
    13621 tcccggtccc atatttccga tacttgaaat caccgtcccg atagattctg tgaaacctac
    13681 gcccattgcc agcatcaaca gtacactgac aatgatgatg acggcataga tgaatgagaa
    13741 tgccagtacc gtcgacagga tggcaggaga aatgacctgt ttgttcaccc gcaccggaag
    13801 tacggcgttc ggatgtacga tgtgtttaaa ttcatttcgt gacactttgg ccagaatcac
    13861 cattcggatg catttcatac ctcctgtggt gcttccggca caggcaccta tcagcatgat
    13921 gacagtcagg gtaccccaaa gtaccggtac ccattgcatg tagtcggctg ttacaaatcc
    13981 ggtggaagta tgcagcgaag ctacttgaaa aaaggctttg cggaaagatt cctcggctcc
    14041 catcggggtg gtgcggtaga gcactgccgc aatgaatgcg gtaaagagaa tcactgacat
    14101 cacgtaccac tttaactcgg cattttgaga tactttcttc agtttaccgg taaatagcag
    14161 gagaagtagc gtaaagttga ttccggagag aaacataaaa acacctatca catattctat
    14221 ataaggtgaa ttgtaatagg ctatgctgtc ttgtttggta gaataacctc ctgtaccggt
    14281 cgtggcaaac gagtggcaga tactgtcgaa cagtcccatg cctccgaata acaaaagaat
    14341 cacttcaatg gctgtcagcc cggcatagat agtccatatc catttggccg tcacaccgat
    14401 acggggatgt actttatcgt aggtaggccc gctggcttcg gcggcaaaga gttgtacgcc
    14461 gctcacaccg aaaatgggca gtacggcaat ggtaaaaaag acaatgccca atccgcctat
    14521 ccactgtgtc atgcttcgcc agaagagaag tccgtggggc agtgcctcga tatcgtcgag
    14581 aatggtggct ccggtactgc tgaatccgga catcgtttcg aagaaggcat tggttatgct
    14641 tggtatataa tggctgaggt agaacgggag cattccaaat aaggaaaaca cgacccatgc
    14701 tacactgaca atgacatatc cgtctcggcg gttaagttgt ttttcggctc ctttgccaag
    14761 agccagcaga aggatggcga ctaaagtagt caatcctgcc gacaacagga aactgctcag
    14821 gtcatcctcg cggtatatca gcgaaacacc tgcacagcaa agtaacaggc ctgtctctat
    14881 cagtaagagg aaacctgtga tgcgatatat cattttagag tttatcatac catcaattaa
    14941 agtacttttc tatcttcttg atcatcatgc tgaggcagaa tacgacgacg tggtcacctg
    15001 cctgaataag ggtatcaccc gtaaccagta taccttctcc gttgcggatc aggccaccga
    15061 tagtggtccc tttgggcagt cccaggtctt tcactttgtt tttggtaatt ttggcgtttt
    15121 cgggtactgt gaattctgct acgtccgcat tggcaaaggt caggcacttc acattcgaaa
    15181 cgtctgcatc gagcatcatc tggtagatgt ggctggcggc aatcattttt ttattgatta
    15241 ccgtgccgat gtccaggctt tccgccatac cgatgtaatc gatattttcc acttccgcca
    15301 ctgttttgct cactcccatg cgtttggcgg caaggcaggc caagatattg gtctcagagt
    15361 taccggtcaa ggctacgaaa gcttccgtgt tcttcagtcc ctcttcaatc aacaggtcca
    15421 tatcccgtcc gtctccgttg ataatcatgg tcttatcatc gagcaactct gtcaggcggt
    15481 tacagcggtt tatgtcgtta tccacaattt ttacctgcat gtaatccggt acatattgtg
    15541 ctgtacggac tgcgatgcgg ctgccgccca taatcatcac attgcgtacg tcggcatatt
    15601 cttcctttcc ggcaattttt cggatgtaag ggatgtattt ccgggtagtg gtgaagtata
    15661 cgatatcgtg cagtttgatg gtatcgtctc cacgggggat aatggtttcg gtaccccgtt
    15721 tgatggctac tacgtgatag ggaatatccg gcgcacctag ttcggccagc gtgacattca
    15781 gtatttcggc tttttcacgc atctttgtac cgatcaggat aagtgatcct ccgcaaaatt
    15841 cccaccattg gcgcacccaa ctcatacgca tggacgatac gatctccttg gcagccagca
    15901 tttccgggta aataagggag tcgacaccca gtttctggaa gaactctttg ttctttggca
    15961 gcaggtattc gtaattgtcg atgcgggcta ctgtcttttc ggctcccaga ttggtggcaa
    16021 gcatgcacgc ggtcatattc cggctttcat cgggagtgac ggcgataaag aggtctgcct
    16081 ctttgatgcc tacctctttc agtcctgata tggacgaagg agaggccgta acagtcatca
    16141 ggtcgaagtt agaactaagc gtacttagtt tctcttcgtc atcgtccatc aggatgatgt
    16201 cctgtttctc gcgtgagagt aatttagcca aatgggtgcc tacagctccg gcaccagcaa
    16261 taattatctt cattgtgatt gcaaattgcg gttctattgc gtattggggg attaagaatg
    16321 ggtagccatg cagctttcca caggagcatc cattcgtaat tcgtttttag taattacctt
    16381 gtaaattcct tcttcatcca tcccgcacaa gtggtagagt tgctgcaccg atccgtgttc
    16441 aatgaactga tccggtacac cgatgcgcct gatttcggga taatatccgt tatcggccat
    16501 aaattcgagt atggcgcatc ccatacctcc tttaatgatt ccatcttcta tcgttacgat
    16561 atggcggaac tttttgccga cttcgtgcag tagctcttca tcgagcggct tgaggaaacg
    16621 aaggtcataa tgcgctacgg aaatgccggt atctgcttca gcacgttcga tggcacgggc
    16681 agccaacttg ccgatagggc cgattgtaat tactgccaga tcgtttccgt cctttagttt
    16741 ccgtcctttt cccaccggaa tctcttccaa cggacattcc cagtccacca acgaaccccg
    16801 cccgcgcgga taacggatgg caaaaggtcc tttgtcgggc aattgggcag tatacatcaa
    16861 gcgccgcaac tcatgttcgt ccatcggtga cgagatagtc aggttgggga tcgggcgtag
    16921 ataagccatg tcgaacacac cgtggtgcgt aggaccgtct tcacctacca gtccggcgcg
    16981 gtcaagacag aatactacat ttagtttttg tatcgctacg tcatggataa tgttatcgta
    17041 agcccgctgc ataaacgagg aatagatgtt gcagaagggc agtaatccgt cttttgccat
    17101 acctccggag aaagtcacgg catgtccttc ggcaatgcct acgtcaaagg cgcgatccgg
    17161 catacgatcc atcagcatgt tcatggagca gccgctcggc atggcggggg tgactcccat
    17221 gatccgtttg ttcttttccg ccagttctac cagcgtatgc ccgaatacat cctgaaacag
    17281 gggaggcatc ccgtccgtat tggctacaat acgttttcct gttaccggat cgaacttacc
    17341 cggggcatgc catatagtgg cctgtttttc tgccggacca aatccctttc ctttgatggt
    17401 gtggaggtgt agaatctttg gtccctgcat atctttaata tcatgcagga tacgggctat
    17461 gttttttaca tcgtgtccgt cgatgggacc gaagtatcgg atattcattc cttcgaagat
    17521 attctgctgt tgggctgcca gagatttcag gctgtttccc aatcttatca aggccttccg
    17581 acgttcttca ttgagcaatc ccattttgaa taacaggcgg gatgtcttga aacgcagttg
    17641 gttgtatcgg ttcgaagtag tgagattgaa cagatattgt ttcatgccgc ctacgctacg
    17701 gtcgatggcc atgtcattat cattgagtat gatcagcagg ttgttcgcag tcgatgaagc
    17761 attgttcaat ccttcgaaag caagtcctcc gctcatggat ccgtcaccga taacggctac
    17821 tacatggcgg tctttttctc cttttctctc ggctgccact gccataccca acgctgccga
    17881 gatggagttg gaggcatgac cgcaagtgaa tgtgtcatat tcactctctt ccggtgaggg
    17941 aaaaggacgg ataccgccca gtttacggtt ggtagagaaa gcttcacgcc gtccggtcag
    18001 tatcttgtgt ccgtaggcct gatgtcccac atcccagaca atacgatcat aaggagtgtt
    18061 gtacacatag tgcagtgcta cagtcagttc taccacaccg aggctggcag cgaagtgtcc
    18121 cgggttgcac gatagttcct taatgatgtc ctgccttaat tcctcgcata cctccggcaa
    18181 ttgatctacg ctcagttggc gcaggtcttt gggataattg atggcgttta gcaagctata
    18241 tgttggttca ttcttcatga ttcgggcaaa tttaaatgca aatttagtaa aagaaagcgg
    18301 aaggagcatc tttttgattg gaaatttaat aagtaagagt ggaaagggag gcggactgac
    18361 aaccttatgg acttataaat gtggtctcct ctttcgttaa cattgttaat gcggttttcc
    18421 gggtgttttc tttttgttgg caaagaagaa gtgttttgtg tttaaaagac ttgttctttg
    18481 caaacaaaac acttgtttta acactctgtt aaatcaagca ttttatatac tgaaagtgaa
    18541 gtcgtttaag ttgttgatac agagtggatc gttgttgttt ctagtttttc tgctatcctg
    18601 cttgtccggg tgtgatgata gatggtattt atcaaaacca caatgatacc gatgccgatt
    18661 ttcaaaaaag gaaggggcga ttgagaagga tgggggatgg gtgatcttgt acggataaat
    18721 aacgtttgtt tgttggaact gttgtttccg ttgtcatcag ttaccgggct tgggtcggtt
    18781 gatgaaagct gcgatgtcat ccgtcacgta agaaggaata gaggagggac ggctgtattc
    18841 aagaggggtt gacttccctt ctccttcctg aaacagatga ttgagtcggg gataagattt
    18901 aaatatcgca ttcggatgct ttgccagggc ggattgccat aattcgaaat cttgcatggt
    18961 gacctgataa tcacgttcgc cttgaaggac aagtatgggg agagtcagtt ttcggaccac
    19021 ttccaaaggt ttatattgat tggcaagcat ccagtaagct tgagagagat tcatgggcaa
    19081 aggagttgta atgtcgaatg tgtctgtacc cagccttttc acgttgtcca cttgtttctg
    19141 taattcggct atttcctttt caatatcttt agccgatggg agtgcagagg cgagaaactt
    19201 cacctgactt ataaacagat cttcgagtgg acgggctgca ccggcaagca gaataatccc
    19261 tgccggaact ttatcgctac gttggacgat gcggggagcc aaggtgcctc ccaggctatg
    19321 tccgagaatg tagatccgtt cgggatttat tgtcggtatg gaacgggcaa gtttaattgc
    19381 cgaaagggcg tcatccactg attcttcatc gaaagtaatt tctttgcctg caggtgcgct
    19441 gtcggctcca tatactttgg tacgcttgtc ataacggatc acggctattc cacgctcggc
    19501 cagtccatac gcgaggtccc gaaaaggttt attggcccct accgtttcgt cccggtcgct
    19561 ggcccccgag ccatgtacca aaatgactac cggcagatct ttgccgtttt taggaagagt
    19621 cagtgtgccg ggaagcttga aattccccgt acaaacctgt atgtctgtct cttttatttt
    19681 atcttgtacc gatgtcgtcg ggggagtggt cttttcaggc ggaacaggta cgaaacgaat
    19741 ggtattcacc tttccgtccg gattgaacgc tgtgagaaaa cgcaatggta agcgttcgaa
    19801 cttaacgtcg caataataaa cagtcatacc gtttattggt tcggtgttcc actctccatg
    19861 cgactgatac ttacctgctt gttgttccaa ttgcttgaac agtccgttca acatctctac
    19921 ggaaagcatt ttccggatgt tatcgtccag atgtacatac acactgtctc cttggcctgc
    19981 aatcagtcgg tcgagaagtt cggatgcctg ttgcgcacga tcctgggctt gcaatacagg
    20041 agttactgcc agcaatagcc atagcaggca gattcctttg agtagatttt tctttgtcat
    20101 aacttgttta ttaagaaatc tccgataaaa aatagagttc cgaggaaaag gattccgtaa
    20161 atcagcaggg agatagaagt cagccaacgg ggctgttttt gctctccgac cgcacggatg
    20221 cgtgcaaacg tactgaacag acattcggcg gcggcaaaca ggactatcag atagatgatc
    20281 aggtcggtcc acgattgtag ccaaaggtct ttgagattac ctatcagaca taccaatatc
    20341 acgatggcta caaaatatga aatacgcatt aagtctgttt tctttgatcc cataagcgtc
    20401 tccttttcag tttttaagtt caaattcttc cctttttgtt gctatttcac aaacttaaaa
    20461 tattttcttt gaaaaaggag cttttcggac tgattctgtt tttccgttaa caattattat
    20521 aaagcttgta ggtgggatgg cagtaaagtt accgctgaat tatccgtatc tttgtcgtaa
    20581 acatagaggt ataaagatat gaagaaactg ataatattcg atttggatgg tactttattg
    20641 aataccattg ctgatttggc acatagtacg aatcatgctc tgcaaacttt gggatatccg
    20701 actcatgaag tcgcttccta taacttcatg gtgggtaacg gcatcaacaa attgtttgag
    20761 cgtgcattgc ccgaaggaga gaaaaccgag gagaatgtgc tccgcgttcg taaagaattt
    20821 cttttgcatt acgaccggca taatgccgac gagagtcgcc cttatccggg aattccggaa
    20881 ttgttggaaa cattgcagca taaaggttat aaattggccg tggcttccaa taaatatcag
    20941 gcagccaccg agaagctgat agcacattat ttcccgggaa tccggtttgt tgctgtattt
    21001 gggcagcgtg agggagtgaa ggtgaagccg gatcctgctg tggtgcatga tattttgcag
    21061 attgccggtg tttcgaaaga cgaagtgctg tatgtcggcg attcgggagt ggatatgcag
    21121 acggctatca atagcggagt tacttcctgt ggagttacgt ggggattccg cccccgtacg
    21181 gagcttgaat cgttctgtcc ggattatata gtagacaagg cggaaactat tttgtctatt
    21241 gtttgataga aaacagaaag gagaaccgaa agatgcgtaa tgtcttaggt tctcctctct
    21301 ataaaaagta attatattcg ctcggttatt tgatttcgtc cggccatggg catggctttc
    21361 cggttgcttt gaatgaaggg cgttggccgc ctactttgcg caaatagtca cccagctctt
    21421 tagataaact tttcacaatg tccggatgta gggctgccag gtcattcttt tctcctatat
    21481 cttccggaat attgaacaac tcttttttac cgctgtcata gtagtaaatc aacttccagt
    21541 cacctttgcg tacggtacag gtcgggccga tgccgggacc gtcgtttccc caatgattag
    21601 ggaagttcca gtgcaggctg cgtcctttgg acggatcacc ggtatgtgtc agcagaggca
    21661 taaaactaat tccatcgatc ggctgtaccg tcttataatg tttgatttgt gccatctcga
    21721 gtatggtcgg atagaagtcc tcgataatta aatatttatc acatttggta tccggtttta
    21781 caactcccgg ccagcggacg atcatcggtt cgcgtacacc gccttcgtaa gccgatcctt
    21841 tcccactgtt gagaggagag ttctgcgtgt gcagttttcc gtcacgccat tccggttcgc
    21901 tggacagacc gccgttgtcg ctcataaaga tgacgatggt attgtctgct tctccgtttt
    21961 tatccagcca gtccatcagg tcacccagac ttttgtccat accttcgatc agggccgcat
    22021 aagcagcttc tttgggagtc aatcctttat tgatatattt ttgatagaag cgtttgtctt
    22081 tatcgatcgg aacatggata gcgtagtgag ccatgtagag gaagaaaggc tgattgtatt
    22141 ctttggcatg atcgagtgct ttgatagctt cgagcgtcag agcttcactg acgaaagtat
    22201 cggttcccca gtatttctct aatcccggaa cggcaaacca gggattcggt ttaccgtccg
    22261 tccggtttcc gtaattattt tcacccaggt agcttgccaa tccgcctcct gcatgtccgg
    22321 ctatgttgac ttcaaagccc atgtgataag gactttctcc cggagtgttg acggcgccga
    22381 aatgtgcttt cccacaatga atcgtgtggt agccattgtc tttcaggatt tctgccagtg
    22441 aggttgcctg aaacgtgtgg tcgatattgg gaacctggca aaccccgttt acattccagt
    22501 ccgctacatt gaatacatcg ctcgggcggt ctgtttgctg gcctttggga tatgtccagt
    22561 tggttacccg gtgacgcgcg gcgttagttc ctgtaatcag gctacaacgg gtgggcgaac
    22621 tgatgctgct ggcataggct tgggtgaaca tcataccttg tttggcaagg cgctccatat
    22681 taggagtttc gtatacctcg ttgtagtgtg tcttttgggt ccagaaaggc agggatgtat
    22741 cttgccagcc catgtcgtct accatgaag
//
