LOCUS       c00300_gnlPro..        14323 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OIJHKPNE_300.
ACCESSION   c00300_gnlPro..
VERSION     c00300_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 08:23:13
            Original ID  :: gnl|Prokka|OIJHKPNE_300
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14323
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14323
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[508:4323]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      509..4323
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14323
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14323
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             3..146
                     /locus_tag="ctg300_1"
                     /transl_table=11
                     /translation="INVRLTDEELAARPMTPVTRDRYVPKSLKAYASMVSSADKGAVRL
                     ID"
     CDS             509..1891
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg300_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.2e-48, bitscore:
                     153.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VGTGFLGTDAFQEVDLVGITQPIAKWSYQIRRAEDVAWAIARAFY
                     IASSGRPGPVVLDFAKNAQVEKTKYEPTKQEFIRSYVPVPDTDEESVKAAAELINNAER
                     PLVLVGQGVELGSAQEELRIFIEKADMPAGCTLLGLSALPTDHPLNKGMLGMHGNLGPN
                     INTNKCDVLIAVGMRFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDIAVLGDCKK
                     TLAAVTGLLKKNRHTEWVDSFKEYEAVEEEKVIRPELHPATDSLSMGEVVRAVSEATRH
                     EAILVTDVGQNQMISARYFKYTRERSIVTSGGLGTMGFGLPAAIGATFGRPDRTVCVFM
                     GDGGLQMNIQELGTIMEQKAPVKIICLNNNYLGNVRQWQAMFFNRRYSFTPMLNPDYMK
                     IASAYDIPSKRVFSREELKAAIDEMLSTDGPFLLEACVVEEGNVLPMTPPGGSVNQMLL
                     EC"
     CDS             1910..2473
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg300_3"
                     /sec_met_domain="ALS_ss_C (E-value: 1.3e-19, bitscore:
                     60.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITAWTDKDTIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQETP
                     EASKVIRRYNARIVEVNPVFSIVEKNGMSEEITSLYEELRALKCVLQFVRSGRVAITTS
                     CFERVNEFLDGQEAKYKQSKKEQE"
     CDS             2473..3216
                     /locus_tag="ctg300_4"
                     /transl_table=11
                     /translation="MSEENKIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHASDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYEKFSVQTWVENVYRLFTDRNFAVIDKDGK
                     KIGYARSVWAMINLNTRKPADLLALHGGSIVDYICDEPCPIEKPSRIKVTSNQPVATLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIELYQTKRIRRFEMAYVAESYFGDELSFFCDEV
                     SENEFHVEVKKNGSEVVCRSKVIFE"
     CDS             3280..4323
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg300_5"
                     /sec_met_domain="IlvN (E-value: 7.5e-47, bitscore: 149.6,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 4e-40, bitscore: 128.0,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     ALNLRDNGFNVIVGQRQGKTYDKAVADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKLEEELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(4856..6802)
                     /locus_tag="ctg300_6"
                     /transl_table=11
                     /translation="MKYIFVSGGRFTTFASIMNNHPKSPIIDLQQQQLLLRMEYEHEKE
                     EFKRQTETMGVARKVKRGLCWYPASPGRSYYNSLNQLVIDITRTENKEIEHSFEFGRPV
                     CFFRQSFDGKVNYMNFIATVSYADDERMVVVLPSAGALLELQTEEVLGVQLYFDETSYR
                     AMFEALEDTIRAKGNRLAELRDTLLGTQKPGFRELYPVRFPWLNSTQETAVNKVLCTRD
                     VAIVHGPPGTGKTTTLVEAIYETLHREPQVLVCAQSNTAVDWICEKLVDRGVPVLRIGN
                     PTRVNDKMLSFTYERRFENHPSYPELWGIRKSIREMGSRMRRGSYSEREGIRSRMSRLR
                     DRATELEILINADLFDSARVIASTLVSSNHRLLNGRRFPTLFIDEAAQALEAACWIAIR
                     KADRVILAGDHCQLPPTIKCIEAARGGLDHTLMEKVVQQKPSAVSLLKVQYRMHEAIMR
                     FPSEWFYNGELEAAPEVRNRGILDFDTPMNWIDTSEMDFHEEFVGESFGRINKQEANLL
                     LQELEAYISRIGKARILDESIDFGLISPYNAQVQYLRSKIRGSSFLRPFRSLITVNTVD
                     GFQGQERDVVFISLVRANEDGQIGFLNDLRRMNVAITRARMKLVILGDATTLTKHAFYR
                     KLIQYIRQEAVSS"
     CDS             complement(6962..7762)
                     /locus_tag="ctg300_7"
                     /transl_table=11
                     /translation="LVRTEFTVHGFRQFHDTISASGSQISSHAPVEREKRSGSSYFRTH
                     IANGRFAGSRQGSRSRSEIFDDGVRSSFYGQNPCKFQDDIFRGSPAAQFSGQADTDNPW
                     HFQFPFHTCHHVYGIRTADTDGHHAQSSSIRSVRVGAYHHSTGESVIFEHYLVNDSGAR
                     LPEADAVTRGYIAQKVVNFFVCFGCRSNVLLCSFVRLYQVVTVHGGGNSHFFFSCIHEL
                     KQCHLGSRVLHSDAVGTEIYVVFTPFVVFHIALIEQVGIQNLLG"
     CDS             complement(7895..8803)
                     /locus_tag="ctg300_8"
                     /transl_table=11
                     /translation="VLATGAFSVIFFSHDNGGDSFGFIHFGCARNGSVGVCRTVPHVVR
                     FAIESIHGSHQHIIRNILQMSAKTQPRSRHRNMVGSTFALRLNQQGHIEYILSVPSGER
                     SQQLQALGSRVDVNRSFRPAGGDIAFIAGGKSSQGEFFAFRFGQFHFFAIMIHQSVFQR
                     IEAKITSNGQCHRQFGRSNKGVCVRIAVRTFGKVAVEGGDDRVLPHRVVRMTFPLTDAR
                     TAGICHDHGADLHEVIHHSVSFGSGANLFGTRIDDQRGSHTQILFLHLPCKGCGTAEIL
                     VRRVGTRTDQPDFHLTRIAVQ"
     CDS             8810..9112
                     /locus_tag="ctg300_9"
                     /transl_table=11
                     /translation="MEPRFLNVRMILAKSFARIHETNLKKQGMLALTFADKADYDKIQE
                     HDLLSVIGLPDFAPGRNLTVVLHHEDGTKESFEAQHTYNEQQIAWFRAGSALNAR"
     CDS             9118..10317
                     /locus_tag="ctg300_10"
                     /transl_table=11
                     /translation="MIEMNKITMQKDGTLSVPDVPVVPYITGDGVGAEVTPSMQAVVNA
                     AVQKAYGGKRRIEWKEVLAGERAFNETGSWLPDETMKAFQEYLIGIKGPLTTPVGGGIR
                     SLNVALRQTLDLYVCLRPVRWYQGVHSPVKAPEKVNMCVFRENTEDIYAGIEWEAGTPE
                     AEKFYQFLKNEMGVTKVRFPETSSFGVKPVSREGTERLVRAACQYALDHHLPSVTLVHK
                     GNIMKFTEGGFKKWGYELAQREFGDALADGRLVIKDCIADAFLQNTLLIPEEYSVIATL
                     NLNGDYVSDQLAAMVGGIGIAPGANINYKTGHAIFEATHGTAPNIAGKDVVNPCSIILS
                     AVMMLEYLGWKEAAALIEKALEQSFLDARATHDLARFMPGGTSLSTTAFTREIVERIEK
                     "
     CDS             10343..11686
                     /locus_tag="ctg300_11"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEEMKEATRIDNELFPKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDVEDISHAIIKEKRFGFEEVAYLLLSGRL
                     PDKEELASFCELINDNMALEQKTKMNIIELEGNNIMNILSRSVLEMYRFDPDADDTSRD
                     NLMRQSIDLISKFPTIIAYAYNMLRHATFGRSLHIRHPQEKLSIAENFLYMLKKDYTEL
                     DARTLDLLLILQAEHGGGNNSTFTVRVTSSTGTDTYSAIAAGIGSLKGPLHGGANIQVA
                     DMFHHLQENIKDWKSVDEIDTYFTRMLNKEVYNKTGLIYGIGHAVYTISDPRALLLKEL
                     ARDLAREKGKEEEFAFLELLEERAIATFGRVKNNGKTVSSNIDFYSGFVYEMIGLPQEI
                     FTPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLDDLAYIPIKKR"
     CDS             complement(12205..12438)
                     /locus_tag="ctg300_12"
                     /transl_table=11
                     /translation="MNLKENKECQYDRIKTTFRVHPHPAHDQKYGGFHQYPRQLVGNGD
                     SPGGSAKYPVTGFHKVEGDENNQSDQTHDAQK"
     CDS             12555..12890
                     /locus_tag="ctg300_13"
                     /transl_table=11
                     /translation="MDILSLTRGNVSFRLVHFRMVYCGQSAFLCRYVDELAFGLYHPSF
                     AQTGGYPSLSAPKRDVPLCYFRQLSGRNHRMGRLGNTDLFTVRTCILLVDSGQSRPPCQ
                     CNLASLP"
     CDS             13095..14207
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Oxidored_FMN"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg300_14"
                     /sec_met_domain="Oxidored_FMN (E-value: 4.7e-46, bitscore:
                     148.1, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLDYHRSVAAGGVGMTTVAYAAVTQSGLSFDRQLWLRPEIISGL
                     REVTGAIHTEGAAAGIQIGHCGNMSHKKICGTTPISASTGFNLYSPTFVRGMKKEELPE
                     MARAYGRAVHLAREAGFDAVEVHAGHGYLISQFLSPYTNHRKDEYGGSLENRMRFMEMV
                     MNEVMTAAGSDMAVFVKMNMRDGFKGGMETDETLQVAKRLLALGAHALVLSGGFVSKAP
                     MYVMRGAMPIRSMAYYMDCWWLKYGVRMFGKWMIPTVPFREAYFLEDALKFRAALPEAP
                     LIYVGGLVSREKIDEVLDAGFDAVQMARALLNEPEFVNRMRREEQARCNCGHSNYCIGR
                     MYTIEMACHQHLKEKLPPCLQREIEKLEKQ"
ORIGIN
        1 cgattaacgt gcgactaaca gatgaagaac tggctgcccg cccgatgact cccgtcaccc
       61 gtgaccgtta cgtgccgaag agcctgaaag catacgccag catggtaagc tctgccgata
      121 agggagcagt gagattaata gactgatcca cttcattatc cattatgaat catccattat
      181 ccattaaaga actatgagta aggacttaat aacaggcgca gaggcaatga tgcgctctct
      241 ggaacatcag ggagtgacta ccattttcgg ttatcccggc ggttccatca tgcctacgtt
      301 cgatgccctg tacgaccatc aaaatacatt gaaccatatc ttggttcgcc atgaacaggg
      361 agctgcccat gcggcacaag gctacgcccg tgtatcgggt aaagtcggtg tttgcttggt
      421 gacaagcggc cccggagcaa ccaatacgat cacaggtatt gcagatgcga tgatagacag
      481 tacgcctatc gttgtcattg caggacaggt gggaacaggc tttcttggaa cagacgcttt
      541 tcaggaagtc gatctcgtag gtatcactca gccaatcgct aaatggagct atcagattcg
      601 ccgtgccgaa gacgtagcct gggcgatagc acgtgctttc tacattgcca gtagtggtcg
      661 tcccggtccg gtggtactcg actttgccaa gaatgcgcag gttgaaaaaa cgaaatacga
      721 gccgacaaag caggagttta tccgcagcta tgttccggtt cctgatacag acgaagaatc
      781 ggtaaaggct gccgccgaac tgatcaataa tgccgaacgc ccgcttgtct tggtaggaca
      841 gggagtggaa ctgggaagcg ctcaggaaga actgcgtatc tttatcgaaa aggcggatat
      901 gcccgcaggt tgtaccttgc tcggactttc cgcattgcct accgatcatc cgttgaataa
      961 aggaatgctg ggtatgcacg gaaatctggg accgaatatc aatactaaca aatgtgatgt
     1021 actgattgct gtcggtatgc gtttcgacga ccgtgtgacc ggtaatctgg ctacttacgc
     1081 caaacaagcg aaagtgatcc attttgacat tgatccggcg gaagtaaata agaatgtaaa
     1141 ggtagatatt gccgttttgg gcgactgcaa aaagacgctg gctgctgtga ccggactgtt
     1201 gaaaaagaac cggcacaccg agtgggtcga tagtttcaag gaatatgaag cggtagagga
     1261 agaaaaagtc attcgtcctg aacttcatcc tgcaacggat tcactgagta tgggcgaagt
     1321 ggtgcgtgcg gtaagcgaag cgacccgtca cgaagccata ttggtgacag atgtaggtca
     1381 gaatcagatg atctctgccc gctactttaa atataccagg gaacgtagta tcgttacttc
     1441 gggtggactc ggcacgatgg gttttggcct tccggcagct atcggagcta ctttcggccg
     1501 tcccgaccgc actgtatgtg tatttatggg tgacggcgga ctgcaaatga acattcagga
     1561 actgggtacg atcatggaac agaaagctcc ggtgaagatt atctgcctga ataacaatta
     1621 tctcggcaac gtgcgccaat ggcaggctat gttctttaat cgccgttatt catttactcc
     1681 gatgctgaat ccggattaca tgaaaatcgc ttccgcctac gatattcctt ccaaacgtgt
     1741 cttttcacgg gaagaattga aagcggctat cgacgaaatg ctctcgacag acgggccgtt
     1801 cctgctcgaa gcctgtgtgg tagaagaagg caatgtcctc ccgatgaccc ctccgggcgg
     1861 ttcagtcaat cagatgttgc tggaatgtta atccttaatt tagaaagtta tgagtgataa
     1921 gacattatat acgattatag ttcattctga aaatatagcc ggattgctga atcaggtgac
     1981 cgctgtattt acccgtcggc aaataaacat cgagagtttg aacgtttctg cttcttccat
     2041 taaaggagta cataaatata cgatcacagc gtggactgat aaggacacta ttgaaaaggt
     2101 ggtgaagcag atcgaaaaga agattgatgt gattcaggcg cactatttta cggaagacga
     2161 gatttatttc catgagatag ccttatataa ggtatctact cctgcttttc aggagactcc
     2221 ggaagcatct aaagtgatcc gcagatataa tgcccgcatt gtagaggtga atccggtatt
     2281 ctctatcgtc gagaagaacg gcatgagtga agagattact tccctttacg aagaacttcg
     2341 ggctttgaaa tgtgtgctgc aatttgtccg ttcgggccgt gtggctatta ctaccagctg
     2401 tttcgaacgt gtgaatgagt tcctggacgg acaggaagcg aagtataagc aaagtaaaaa
     2461 ggaacaggag taatgagtga agaaaataaa atagggactt atcagtttgt ggcagagccg
     2521 tttcacgtag attttaacgg ccgcctgacc atgggcgtgc tggggaatca tctgctgaat
     2581 tgcgcaggtt ttcatgccag cgaccgtgga tttggtattg ctacgctgaa cgaggacaat
     2641 tacacatggg tgctttcccg cctggctatc gagctggatg agatgcctta ccagtacgag
     2701 aagttctcgg ttcagacatg ggtggagaat gtctatcgtc tctttaccga ccgtaacttt
     2761 gccgtcattg acaaggatgg aaagaagatc ggctatgccc gttccgtatg ggcgatgatc
     2821 aatctgaata cccgtaagcc tgccgatctg ttggcattgc atggaggaag catcgtcgat
     2881 tatatatgcg atgaaccctg cccgatagaa aagccttcgc gtatcaaggt gacaagcaat
     2941 cagcctgttg cgacgctgac ggcaaaatac agtgatatcg atattaacgg acacgtaaac
     3001 agtattcgtt atatcgagca catacttgac ttgtttccga tagaactgta tcagacgaaa
     3061 cgtatccgcc ggtttgaaat ggcgtatgtg gctgaaagtt atttcggaga tgaactctct
     3121 ttcttctgtg atgaggtgag tgaaaacgag tttcatgtag aggtgaagaa aaacggcagc
     3181 gaggtagtat gccgttccaa agtgatattt gaataatata gagtataaaa tcaattaata
     3241 acagatggcg caagtcatca aaacaaaaaa acaaaaaaaa tggcacagtt gaattttggc
     3301 ggaactgtag aaaatgtagt tatccgtgat gaatttccat tggaaaaagc tcgtgaagta
     3361 ttgaaaaatg aaacaatcgc tgtaatcggt tatggcgtac aaggtcccgg acaggctctg
     3421 aaccttcgtg ataacggttt caatgtaatc gttggtcaac gccagggaaa gacatatgac
     3481 aaagcggtag ctgacggatg ggtcccgggt gaaactttgt tcggtattga agaagcttgc
     3541 gaaaaaggta cgatcattat gtgcctgttg tctgatgcag cagtaatgtc tgtatggcct
     3601 actatcaagc cttacctgac tgcaggaaaa gctctttatt tctctcatgg ttttgctatt
     3661 acatggagtg accgcacagg tgtagttcct cctgcagata tcgacgtaat catggttgct
     3721 cctaaaggtt cgggtacatc cttgcgtact atgttccttg aaggtcgcgg gttgaactct
     3781 tcatacgcta tctatcagga tgcaacaggc aacgctatgg acagaacaat cgcattgggt
     3841 atcggtatcg gttcaggtta tttgttcgaa acaactttca tccgcgaagc tacttccgac
     3901 ctgacaggcg aacgtggttc attgatggga gctatccagg gtctgttgct ggcacaatac
     3961 gaagtgttac gtgaaaacgg tcatactcct tccgaagcat tcaacgaaac tgtagaagag
     4021 ctgactcagt cattgatgcc gttgtttgca aagaacggta tggactggat gtatgctaac
     4081 tgctctacta cagctcaacg tggtgctctc gactggatgg gccccttcca cgatgctatc
     4141 aaaccggtag ttgaaaagtt gtatcacagt gtgaagactg gtaacgaagc acagatttca
     4201 atcgactcta actccaaacc ggattatcgt gagaaactgg aagaagaact gaaagcattg
     4261 cgcgaaagcg aaatgtggca gactgccgtg acagttcgta aacttcgtcc ggaaaataat
     4321 taatcagact tatactatat aagtttttca aaaggcggga aaagcgtatt ttcccgcttt
     4381 ttctatgtag ataccggtct tttgagtaat agaaaaagga tgaaagtaga aaaaaagatt
     4441 aaaagatact gataatatag gtgaaaaaga gcatttatga ttacctttac ggcaacaaat
     4501 aaaacagaat aggcaatgaa gaaacttttt acttacagaa gatcgatacg tatgaagatg
     4561 atttcttctt taataaatag tatatcagaa tgttacatta aaagatattt aagttattct
     4621 ctaccgaatg gtagctgtaa taccatttca agtccttttt atatttcgtg ttccattagt
     4681 gattcgttga tatgatgcag aattttattc tgtagcagga aaaagtatgc gttaaattga
     4741 atttaagaca gagcttttgg aacagaattt agtgggaaaa taacattgtt tgttttgttt
     4801 gtaaatggga gtcctctttc gtgagaaagg gggcttcttt ttttatcccg atgattcagg
     4861 aggataccgc ttcctgccgg atatactgta tcagtttccg gtagaacgca tgcttggtaa
     4921 gagtggttgc atctcccaaa atcacaagtt tcatccgggc gcgggtaatg gctacgttca
     4981 ttcgtcttaa atcattcaga aaaccgatct gtccgtcctc gttcgcccgg acgaggctga
     5041 taaagacgac atcccgttcc tgtccctgaa agccgtctac cgtgttgacc gtgatgaggc
     5101 tgcggaaagg gcggagaaaa ctgcttcctc tgattttact tctcaggtat tgcacttgcg
     5161 cattgtaggg cgaaatcaga ccaaagtcga tgctctcgtc caggatgcgt gctttgccga
     5221 tccggctgat ataggcttcc agttcttgca gtaacaagtt ggcttcctgc ttgttgatgc
     5281 gcccgaagct ctcgcctaca aactcttcgt ggaaatccat ttccgaggta tctatccagt
     5341 tcatgggagt gtcgaagtca aggatacccc ggttgcgcac ttccggtgcg gcttccagtt
     5401 ctccgttgta gaaccattcg gagggaaagc gcatgattgc ctcgtgcatc cggtattgca
     5461 ctttgagcag cgagacggca gaaggttttt gctgcacgac tttttccatt aaagtatggt
     5521 ccagtccgcc acgggcggct tcgatacatt tgattgtagg agggagctgg caatggtcgc
     5581 cggcaagaat cacacggtcg gcctttcgga tggcgatcca acaggcggct tcgagtgcct
     5641 gggcggcttc atcgataaat aaggtgggga aacgccttcc gttgagcaaa cggtgattgc
     5701 tgctgaccag cgtagaagca atcacacggg cactgtcgaa aagatcggcg ttgatcagga
     5761 tttccagttc ggtggcacgg tcgcggaggc ggctcatccg gctgcgtatt ccttcccttt
     5821 cggagtaact tccccgacgc atccggctgc ccatttcacg gattgatttt cggattcccc
     5881 aaagttcggg gtagctcgga tgattctcaa agcggcgttc gtaggtgaaa gagagcattt
     5941 tatcattaac acgcgtagga ttaccaatgc ggagcacagg aacaccccgg tccaccagtt
     6001 tctcacaaat ccagtccacg gccgtattac tttgggcgca gaccagcacc tgcggttcgc
     6061 ggtgaagcgt ttcgtaaatg gcttccacaa gcgtggtagt ctttccggtt cccggagggc
     6121 cgtgtacgat ggcgacatcg cgtgtgcata acactttgtt tacggctgtc tcctgcgtgc
     6181 tgttcagcca cgggaaacgg acgggataca attcgcggaa tcccggcttt tgtgttccca
     6241 gcaaggtgtc ccggagttcg gcaaggcggt tgcctttggc gcggatcgtg tcttccagcg
     6301 cttcgaacat ggcacgatag gacgtttcat cgaaataaag ttgtacaccc agcacctctt
     6361 ccgtttgcag ttccagcaat gcgcctgcac tgggaagcac gaccaccatc cgttcatcgt
     6421 ccgcataact caccgttgca atgaagttca tataattcac ttttccgtca aatgactgac
     6481 ggaaaaagca gacgggacga ccgaattcga aggaatgctc gatttcttta ttttcggtgc
     6541 gtgtaatatc tattacaagt tgatttagag aattatagta acttcgaccg ggagaggcgg
     6601 gataccagca cagaccacgt ttcactttgc gggcgacacc cattgtttca gtctgccgct
     6661 tgaattcctc cttttcgtgt tcatactcca tgcgtagcag gagttgctgt tgctgaaggt
     6721 cgatgattgg acttttcgga tgattattca taatagatgc aaaggtagta aatcttcctc
     6781 ctgagacgaa aatatatttc attttgttaa acattcctcg aacgccgttc gttattttta
     6841 tagatagact aaaaaaaata aaagcaatat ggtgtatgat ttgactatgt tagaggcttt
     6901 ttattctgct tataaaggaa aagtggaaca cgtgcgggct gttttgaaac gccctttgac
     6961 gttagccgag aagattctgt atgcccacct gttcaatgag ggcgatgtga aaaactacaa
     7021 acggggtgaa gactacgtaa atttccgtcc cgaccgcgtc gctatgcagg acgcgactgc
     7081 ccagatggca ttgcttcaat tcatgaatgc aggaaaagaa aaagtggctg ttccctccac
     7141 cgtgcactgt gaccacttga tacaagcgta caaaggagca aaggaggaca ttgctacggc
     7201 aaccaaaaca aacgaagaag tttacgactt tttgcgcgat gtatcctctc gttacggcat
     7261 cggcttctgg aagccgggcg ccggaatcat tcaccaggta gtgctcgaaa attacgcttt
     7321 ccccggtgga atgatggtag gcaccgactc tcacactccg aatgctggag gattgggcat
     7381 ggtggccatc ggtgtcggcg gtgcggatgc cgtagacgtg atgacaggta tggaatggga
     7441 actgaaaatg ccaaggatta tcggtgtccg cctgaccgga aaattgagcg gctggacttc
     7501 cccgaaagat gtcatcctga aacttgcagg gattctgacc gtaaaaggag gaacgaactc
     7561 catcatcgaa tatttcggac cgggaacggc ttccctgtcg gctaccggca aagcgaccat
     7621 ttgcaatatg ggtgcggaag taggagctac cacttcgctt ttcccgttcg acgggcgcat
     7681 ggctacttat ctgagagcca ctggcagaga tcgtatcgtg gaactggcgg aagccgtgga
     7741 ctgtgaactc cgtgcggacc aacaggtgac ggacgaaccg gaaaagtact acgaccgtgt
     7801 cattgacatt gacttgtcca cgctcgaacc ttacatcaac ggccctttca caccggatgc
     7861 cgctacccct atctctgaat ttgcagaaaa agtattactg aacggctatc cgcgtaagat
     7921 ggaagtcggg ctgatcggtt cgtgtaccaa ctcttcttac caagatctca gccgtgccgc
     7981 atcccttgca aggcaggtga aggaaaagaa tctgagtgtg gcttccccgc tgatcatcaa
     8041 tccgggttcc gaacaaattc gcgccactgc cgaaagagac ggaatgatgg atgacttcgt
     8101 gcagatcggc gccgtgatca tggcaaatgc ctgcggtcct tgcatcggtc agtggaaacg
     8161 tcatacggac gacccgatgc ggaagaactc gatcgtcacc tccttcaacc gcaactttgc
     8221 caaacgtgcg gacggcaatc cgaacacata cgcctttgtt gcttctcccg aactgacgat
     8281 ggcactgacc attgctggtg atctttgctt caatccgctg aaagacagac tgatgaatca
     8341 tgatggcgaa aaagtgaaac tggccgaacc ggaaggcgaa gaactcccct tgagaggatt
     8401 tacctccggc aatgaaggct atatcgcccc cggcgggacg aaaactgcga ttaacgtcaa
     8461 cccggcttcc caacgcctgc aactgctgac tcctttcccc gcttgggacg gacaagatat
     8521 actcaatatg cccctgctga ttaaggcgca gggcaaatgt actaccgacc atatttcgat
     8581 ggcgggaccg tggctgcgtt ttcgcggaca tttggagaat atttcggata atatgctgat
     8641 gggagccgtg aatgctttca atggcgaaac gaacaacgtg tggaaccgtt cgacaaacac
     8701 ctacggaacc gtttcgggca cagccaaaat gtataaatcc gaaggaatcc cctccattgt
     8761 cgtggctgaa gaaaattacg gagaaggctc cagtcgcgag cacgcggcaa tggaacctcg
     8821 tttcctgaat gtgcgtatga ttctcgccaa gagcttcgcc cgtatccacg aaacgaatct
     8881 gaaaaagcaa ggcatgcttg cccttacttt tgcggacaaa gcggattatg acaagataca
     8941 ggagcacgat ctcctttcag tcatcggctt gcccgacttt gctccgggac ggaatctgac
     9001 cgtcgttctc catcacgaag acggaacgaa agagagtttt gaagcgcaac atacatacaa
     9061 cgaacagcag attgcctggt tccgtgccgg ctctgccttg aatgccagat aattaaaatg
     9121 atagaaatga acaaaataac catgcaaaaa gatggtacgc tatcggtgcc cgatgtgcct
     9181 gtcgtacctt atattaccgg agacggagta ggagcggaag tgactccatc aatgcaagcc
     9241 gttgtgaacg cggctgttca gaaagcatac ggcggcaaac gtcggattga atggaaagaa
     9301 gtgctggcgg gcgaacgcgc tttcaacgag acaggctctt ggctgccgga tgaaacgatg
     9361 aaggctttcc aagaatatct gatcggcatc aagggtccgc tgacgacccc tgtcggcggt
     9421 ggaatccgtt ctttgaacgt agctttgcgc caaaccttgg atttatatgt ttgtttgcgt
     9481 ccggttcgtt ggtatcaagg cgttcattct ccggtgaaag caccggaaaa agtgaacatg
     9541 tgcgtgttcc gtgaaaatac ggaggatata tatgcaggaa tcgagtggga ggcaggtact
     9601 cccgaagctg aaaagttcta tcaattcctg aaaaacgaga tgggagtgac gaaagtccgc
     9661 ttccccgaga cctcttcttt tggggtgaaa cctgtttccc gtgagggcac ggaacgtctt
     9721 gtgcgggctg cctgccagta tgcgctcgac catcatctgc cttctgtgac actggtgcac
     9781 aaaggaaaca ttatgaagtt caccgaagga ggtttcaaga aatggggcta tgagctggcg
     9841 caacgtgagt ttggcgacgc gctggcagac ggccggctgg tgataaagga ctgcattgcc
     9901 gatgcttttc tgcaaaatac attactgatt cccgaagagt attccgtgat tgccacgctg
     9961 aacctgaacg gagactatgt ttccgaccag ttggcggcaa tggtaggcgg catcggcatt
    10021 gctccgggag caaatattaa ctacaagacg gggcacgcca tttttgaagc gactcatgga
    10081 accgccccca acattgccgg aaaggatgtc gtgaatcctt gttctatcat tctttcggcg
    10141 gtgatgatgc ttgaatatct gggatggaaa gaagcggccg cgcttatcga aaaggcgttg
    10201 gaacagagtt tcctcgatgc ccgtgccacg catgatctgg ctcgctttat gccgggaggt
    10261 acatccctgt ctaccaccgc tttcacacgc gaaattgtgg aaagaatcga aaagtaaatg
    10321 taacgattaa aaacgaagta ttatgaagaa agagtatttg atttacaagc tctccgagga
    10381 gatgaaagag gcaacccgga ttgacaatga attgttcccc aagtttgacg tgaagcgtgg
    10441 actacgtaat gaagacggca ccggtgtatt ggtaggtctg acaaagattg gtaatgtggt
    10501 gggttacgaa cgtatccccg gcggcggtct gaagcctatt ccgggaaaat tgttctatcg
    10561 gggctatgat gtggaagata tttcccacgc catcatcaag gaaaaacgtt tcggcttcga
    10621 agaagtggct tatctgctac tctccggtcg cctgccggac aaggaagaac tggcttcgtt
    10681 ctgcgaactg atcaatgaca atatggcgct cgagcagaag acgaaaatga atattatcga
    10741 gctggaggga aataatatca tgaatatcct ttcgcgcagc gtactcgaaa tgtatcgttt
    10801 cgatcccgat gccgacgata cttcccgcga caatctgatg cgccagagta tcgatcttat
    10861 ctccaagttc ccgaccatca ttgcgtatgc ttataatatg ctccgccatg ctacattcgg
    10921 ccgttccctg catatccgtc atccgcagga aaaactctct attgccgaga atttcctcta
    10981 tatgctcaaa aaagattata cggaactgga tgcccgtacg ctcgacttgc tattgatttt
    11041 gcaggcagaa catggcggtg gtaacaactc gactttcacg gttcgtgtga cttcttccac
    11101 cggaacagat acatattcgg ccatcgccgc aggtatcggt tcgttgaaag gcccgcttca
    11161 cggaggcgcg aatatccagg tggccgatat gttccatcac ttgcaggaga acatcaagga
    11221 ctggaagagc gtggacgaga tagataccta tttcacacgg atgctgaata aggaagtgta
    11281 taataagacc ggactgattt acggtatcgg tcatgctgtt tacacgattt ccgatcctcg
    11341 tgcgctgttg ctgaaagaac tggctcgcga ccttgcccgt gagaaaggaa aagaagagga
    11401 gttcgctttc ctcgaactgc ttgaagagcg tgccatcgct actttcggac gtgtgaagaa
    11461 caacggaaag acggtttcca gcaatatcga cttctattcg ggtttcgtat atgagatgat
    11521 tggtttgccg caggagattt tcactccgct gtttgccatg gctcgtattg tcggctggtg
    11581 tgcgcaccgc aatgaagaac tgaacttcga gggcaaacgc attatccgtc cggcttataa
    11641 aaatgttctt gatgatctgg cttatatccc catcaagaaa cgctgataag aacaaatcct
    11701 tttatgcaat aataactaac ctcagacgta catctcggca atccctgcat gtacgtctcg
    11761 gtaatcccca gttgtacatc ttggtagtac ccggttgtac gtctggggtg acttgtttca
    11821 ggaagaacgt ccgatgttca tttaacattt aacactttgc ggctgctgta tttttcatcc
    11881 gatggaggct aaggcattta tcgttggtag aaagggcaca gcctggcagg tagaaacgcc
    11941 cttttaacgc tacgttaaaa gggcgtttct acaaccgatg aattatatat tctattcctt
    12001 tggatatcag tggactatgt gctaaaagcc catggtgtca tatgaaagag aacacgggat
    12061 ggaaaaaaga taattgtgat attcataagt ttcctgtccg gtcaatacga atagttcttt
    12121 cagttttttg tggccattct tttctttttt tgttattttt gtgaatctca aaagaaaatc
    12181 aagatgagta taactgcctt taatctattt ttgggcgtca tgagtctgat cgctctgatt
    12241 gttttcatcg ccctctactt tgtgaaagcc ggttacggga tatttcgcac tgcctcctgg
    12301 ggagtcgcca tttccaacaa gctggcgtgg atactgatgg aagcccccgt atttctggtc
    12361 atgtgctgga tgtggatgca ctcggaacgt cgttttgatc cggtcatact gacattcttt
    12421 attttctttc agattcatta ttttcagcgc gccttcgtct ttcccctgct actgaccgga
    12481 aagagcaaaa tgccgctggc aattatgtcg atgggaatcc tgttcaatct attgaacggc
    12541 tatatgcagg gcgaatggat attttatctc tcacccgagg gaatgtatca ttccggctgg
    12601 ttcacttccg catggtttat tgcgggcagt ctgcttttct ttgcaggtat gttgatgaac
    12661 tggcattcgg actatatcat ccgtcatttg cgcaaaccgg gggatacccg tcattatctg
    12721 ccccaaaaag ggatgtaccg ctatgttact tccgccaatt atctgggcga aatcatcgaa
    12781 tgggcaggct gggcaatact gacctgttca ctgtccggac ttgtattctt ctggtggaca
    12841 gtggccaatc tcgtcccccg tgccaatgca atctggcatc gctaccgtga agaatttggc
    12901 tcggaagtag gcggacgcaa acgtgtattt ccttttatct attgatttga aataaattat
    12961 ctattgacat aaaatagcgt actatggaat ctaaactttt cacccctgtc actttcggtc
    13021 cattgacgct gcggaatcgt acgatccgct ctgccgcttt tgaaagcatg tgtcccggta
    13081 acgccccttc acaaatgctg ctcgattacc accgctcggt ggctgcgggc ggagtcggga
    13141 tgacgactgt agcctatgca gccgtgacgc aaagcggact ttctttcgac cgtcagttgt
    13201 ggctgcgtcc ggaaatcatt tccggtttac gtgaagtgac cggagctata cacacggaag
    13261 gtgcggcagc aggcatccag atagggcact gcggaaatat gtcccataaa aagatttgcg
    13321 gaaccactcc catttcggcc tctaccggtt tcaatctcta ttctcctaca ttcgtgcgtg
    13381 gcatgaagaa agaagagttg ccggagatgg ccagagccta cggacgggct gtccacttgg
    13441 cacgggaagc cggcttcgac gccgtggagg tgcatgccgg acacggatat ctgatcagcc
    13501 agttcctgtc tccctacacc aatcaccgga aagacgaata cggcggctcg ctcgaaaatc
    13561 ggatgcgctt tatggaaatg gtgatgaacg aggtgatgac agcagcggga agcgatatgg
    13621 cggtctttgt aaaaatgaat atgcgcgatg gcttcaaagg tggcatggaa accgatgaaa
    13681 ccttgcaagt ggccaaacgc ctgctggcat tgggcgcgca cgcattggta ctgagcggag
    13741 gcttcgtcag caaagccccg atgtacgtca tgcggggagc gatgccgatt cgttcgatgg
    13801 cttactacat ggactgctgg tggctgaaat acggggttcg gatgtttgga aagtggatga
    13861 ttccgaccgt tcctttccgg gaagcctatt tcctggagga tgcactgaaa tttcgggcgg
    13921 cacttccgga agctccgttg atttatgtgg gcggactggt gtctcgcgaa aagatagatg
    13981 aagtattgga tgccggcttc gatgccgtcc agatggcacg tgcgttgctc aacgaaccgg
    14041 agtttgtcaa ccggatgagg cgggaagagc aggcacgctg taactgcggg cacagcaact
    14101 actgcatcgg gcgcatgtac actattgaaa tggcctgcca ccaacatttg aaagaaaagc
    14161 tgcctccctg cctgcaacgg gagattgaaa aactggaaaa gcaatgagtg aagagaaatg
    14221 ggcaatcatc accggtgccg acggcggcat gggaacggaa ataacccgtg ccgtagccga
    14281 agccggttac catattatta tggcttgcta tcgtccgtcc aaa
//
