LOCUS       gnlProkkaPKJABHOB_370   8932 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PKJABHOB_370.
ACCESSION   gnlProkkaPKJABHOB_370
VERSION     gnlProkkaPKJABHOB_370
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 10:39:31
            Original ID  :: gnl|Prokka|PKJABHOB_370
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 8932
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..8932
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1787:4992]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1788..4992
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..8932
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..8932
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             107..1273
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg370_1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 3e-33, bitscore:
                     104.0, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVIYIQDQEIDHYNGQFYHSKSEHFFSRFLAGLNENDTLTVYTG
                     IINRNCAQEVAKYKDVTNPRITYKQVPEFRNPKNLLAINRLMKRVLKDADFCYLRSGIA
                     ASFASTICLKKHIPYMAVVNEDIFRNTIAHSRLLVRLSAYPLSYYTHRMVREANYACYV
                     TQDYLQSNYPCKGKSLGCSDIEFLDINELSLTKRLNKIQKQEGTIVLGTVGSVDTELKG
                     QDTIIKALAKLKAEGFTNYIFQMVGTGKPNRLRNLAAEFGIANQIEFLGEFKHDDVQKW
                     FETIDIYVHPSRSEGLPRTILEAMTKAVPCICSSVGGIPELIDGDSLFTYDGTEIDTLV
                     NIIKGFSKDKMEFEAKINFERSKNYEPKLLEQKRTVFFAQAINEFRKK"
     CDS             1788..3098
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 190.2;
                     E-value: 7.4e-58)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg370_2"
                     /sec_met_domain="CTP_transf_like (E-value: 1.2e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.2e-114, bitscore:
                     371.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 6.9e-62, bitscore:
                     198.1, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTVYLGMIGDIMHPGYINIINKATEYGDVIIGLFTDKAIANHR
                     RLPYLTWEQRKNVVESIRNVSRVVPQDDWSYVSNLLKYKPDYIIHGDDWLVGPDKYIRD
                     EVFKVMEKLGGEVIEIPYTQNISASGIKQEIDTLGVTPQMRLSSLRRLIAAKPIVRILE
                     SHNGLTGLIAEHTKVEVDGQEREFDGMWASSLTDSTSKGKPDIEAVDLTTRLHDLNDTL
                     EVTTKPVIFDGDTGGKIEHFGFTVRTLERLGISCVIIEDKVGLKQNSLFGTDAVQTQDT
                     IEGFQAKIRAGKEAQITRDFMIVSRCESLIAGKTVDDALERCHAYVEAGTDGIMIHSKE
                     KSGEDIKEFCFRFREKDAHTPIIVVPTTYNQFTEEELAEWGINVVIYANHMLRSAYPAM
                     VKCAETILYTSRSLEASEQYCMPIKQILNLIPGTKKK"
     CDS             3133..4260
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 74.8;
                     E-value: 1e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg370_3"
                     /sec_met_domain="TPP_enzyme_N (E-value: 4.8e-21, bitscore:
                     64.2, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.6e-24, bitscore:
                     74.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRPEFFVNILKEQGIDFYAGVPDSLLKNICAYITDHLPAEQNII
                     AANEGGAMGIAVGYHLATGKVSVVYMQNSGEGNIINPFASLTDKDVYNIPVLLVIGWRG
                     RPGVHDEPQHVKQGKVTIGLLNTMGINYAILPKDEEGAAKQIKIAVDFMKATNECYALV
                     IEKDTFDTYKLQSVEVNELAMSREETIQKVASNIEDNACIVSTTGMISRELFEARTAWS
                     QGHERDFLTVGAMGHASQIALGIALQKPERRVYCFDGDGASIMHMGNMAITASMKCKNY
                     VHIVFNNGAHDSVGGQPTVGLKIDFCAIAQAVGYKAAYSVETMEALEAKLAEFKNAEGP
                     VFLQICVKKGNRKDLGRPTTTPIQNKEAFMEFLNK"
     CDS             4264..4992
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Metallophos_2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg370_4"
                     /sec_met_domain="Metallophos_2 (E-value: 1.3e-27, bitscore:
                     85.9, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVILFADIHANLSAFEAVLVDIEKHYQPDAMISLGDFIDYGMRS
                     NEIIERIQTVNIPLLANLKGNHEKALIDGELSCFSSERARVMSKYTRNHLTQTSIDYIS
                     NVMQEPMQELEIGGKKVLLLHGTIDDPYWGKLTPAKVEDEKYQDFDYVLSGHIHQPFKI
                     DVFFKVDNPIMRNQKRTTFINPGSVGQPRNQNPYAQYVYINFETGETHFNAVPYDIEAE
                     QSLFPKEIDTFYSERLKFGI"
     CDS             4993..5988
                     /NRPS_PKS="Domain: NAD_binding_4 (83-198). E-value:
                     6.4e-10. Score: 30.4. Matches aSDomain:
                     nrpspksdomains_ctg370_5_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     143.1; E-value: 2.2e-43)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg370_5"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 6.6e-10,
                     bitscore: 27.6, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.3e-09, bitscore:
                     25.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLYVISGVTGMTGSELSRQFVSQGHTVIGFDNFFASSIDTVKD
                     IIDNPSFIFYNYDINKVAQMDEVCDKAKELKIECDGRLVFINCAAVVHTKHFYEVESTF
                     QTNVLAMKDFLERAISMRADTYINCSTSEVYSMQSWNENGGVKESDYLAMSTAEHSQRT
                     SYACGKLMTEFFMKDAVGKGRIKGCSIRFANVYSRHERFAEHIIPHIIDNLLESHTVTL
                     LENSKVNKRTFLHNIDSCRAVMELIASEDALDGTVYNVATEEEIAIIDLVKTIAIKMGI
                     NDVDIRFEGYRKSDPERRLLNTDKIRTRTSWKPIITLDEGLTMCVNSIKK"
     aSDomain        5242..5586
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg370_5_NAD_binding_4.1"
                     /evalue="6.40E-10"
                     /label="ctg370_5_NAD_binding_4.1"
                     /locus_tag="ctg370_5"
                     /protein_end="198"
                     /protein_start="83"
                     /score="30.4"
                     /tool="antismash"
                     /translation="VFINCAAVVHTKHFYEVESTFQTNVLAMKDFLERAISMRADTYIN
                     CSTSEVYSMQSWNENGGVKESDYLAMSTAEHSQRTSYACGKLMTEFFMKDAVGKGRIKG
                     CSIRFANVYSR"
     CDS             5985..6725
                     /locus_tag="ctg370_6"
                     /transl_table=11
                     /translation="MKYLIITVAGTATRFNRDTKEETLKCLYYTDEPQYALLAQLLKNC
                     GEYDKYILVGGYLYEKLGRFVKNELSGYGKKIELVYNEHFKDYGSGYSLYKGIEAIKEA
                     GDVTFVEGDLFFMATDFRQVYNSPKSVITINREPIYSNKAVALYINVDGKPRYLYDTNH
                     QTLTVSEPFKAIFNSGQMWKFSSSERLLKTVDSLTKEQLQGTNLEIIQAYFSDMNSEEY
                     DVVTFTDWFNCNTVADYDIVRKLM"
     CDS             6734..7741
                     /locus_tag="ctg370_7"
                     /transl_table=11
                     /translation="MAVLERDYRIDGIKWLLIVLVTFGHVIEPALSNPIANKLYSIIYI
                     FHMPLFVFISGYYANVKDKEKLISKGFMLLETFLVVMIPQCFYYGSIIPLLNPKNSGWY
                     LISLITWYIIFLLIINKLVGKIVVQYNGCGGQLLIFSCLLAVFAYMLPLKQFGNLLSFQ
                     RSCMFLPFFMMGFLRRVKGLPIIPDVSKCIKLVLAIASLVCFAFCLIYSGRILHVLEFN
                     NANVWHMSNLYNQNIGMLLVLKVLVYIGSIITTFAVLMFVNLPKSICAYGSKTLAYYVI
                     QGMFAHILSTYLQVNFYQALFLCVCILVLTTVLLRFVDSKFITNPFSTLLKWKY"
     CDS             7798..8916
                     /locus_tag="ctg370_8"
                     /transl_table=11
                     /translation="MIIGLGSVGCYLLDYLVSLGDSQLRLVVVGRNAEKMQMDINIIRT
                     ASTIRHQCRSEIKVVDNCDLNDVNSIAAVLEAEKPDFIVNSSRVYSGLKYGSISWSNLR
                     AYGIWTPLSIRYAKNIMEAYDKANCEAISINTSYSDAVIPWLKSAGKAYFDFGSGNLNH
                     LVPRIKFYIAEKYGIKNFNDIDVTIAVSHFHDVVISKEGHAEGQDILLDIKFQGKDMDF
                     NKEELLKSCSIAMPVDQKRNMMNASSNFDIIFSVLTALREEKQVKIHTPGVNGEIGGYP
                     IIIDGVTATAKFDESVWTIDQMRKANRESIYCDGVENITDATLVYTDELVAKVKKSFNV
                     DLPKSVKFVDIENVADLIINQIIKPQVFVFVQ"
ORIGIN
        1 tagtaatggt tttgttttat gcttggttgt atttctttgt tttcaaaaga aaatcaagcc
       61 tacatcgaac tagaacaact tattgaatat tcttaaatag cttgtaatgg acgtaatata
      121 tatacaagat caggaaattg accattacaa tggccaattc tatcattcca aatcggagca
      181 cttcttctca cgttttcttg cgggcttaaa tgagaatgat actttgacag tatatacagg
      241 catcatcaat cgtaactgtg ctcaggaggt ggctaaatac aaggatgtaa ctaaccctcg
      301 tatcacttac aaacaggtac cggagtttcg taatccgaag aaccttcttg ctatcaatcg
      361 cttgatgaaa cgggttctca aggatgcaga tttctgctat ttgcgtagtg gcattgctgc
      421 ctcatttgcc agcactattt gtctcaagaa gcatataccc tatatggcag tagtgaatga
      481 ggacatattc cgtaatacga ttgcccattc tcgtctattg gttcgtttgt cagcctatcc
      541 tctttcttat tacacccatc gcatggttcg agaagctaac tatgcttgct atgttacaca
      601 ggattatctg cagagtaact acccatgcaa aggcaagagc cttggttgtt cggatattga
      661 gttccttgat attaatgagt tgtcattgac aaaacgtttg aataagattc agaagcaaga
      721 gggaacgatt gtactgggaa ctgtaggatc agtagataca gagttgaaag gacaggatac
      781 tatcatcaag gctttggcaa aactaaaagc cgaaggtttc accaactaca tatttcaaat
      841 ggttggaaca ggtaaaccta atcgtctacg caatctagct gccgagtttg ggattgctaa
      901 tcagattgaa tttctaggcg agtttaagca tgatgatgtt caaaaatggt tcgaaactat
      961 tgatatttat gtacatccca gtcgttcaga aggtctccct cgtaccatct tagaagctat
     1021 gaccaaggct gttccttgta tttgctcttc tgttggtggt ataccagaac tcatagatgg
     1081 tgattcgctt tttacttacg atggtacaga gattgatact ttagtaaata taatcaaagg
     1141 ctttagcaaa gataagatgg agtttgaggc aaagattaac tttgagcgtt caaagaatta
     1201 cgaaccgaaa ttacttgagc aaaagcgaac tgttttcttt gcacaggcta tcaatgaatt
     1261 tcgtaagaaa taaaagataa aatcgacatt atgaatttat attattcttg aatttgtcgt
     1321 aaacttggat tctctaataa cgacaatatg ggaaccgcat accgcaagac tatctaactt
     1381 tgatggtata tgaccaataa aagaaatcac aagcttttga gattctctct aatacagaca
     1441 aattcttgtt tgtggacaat ggtagtaagg cttgtctttt tgttgaaacc tataactatg
     1501 cttctcataa tggggagtgt tcgttgtaat tgacagaaag ccacagaact tccgcatcat
     1561 cattgttact ccaattcaat ggcatatcca ttcttctttt agcacaatgg tagagtccta
     1621 cagttccttt gctctccgca aatggagaaa cttattgagt ggttcagaag tgtagtcgaa
     1681 cttatggtaa atctatctat gtgtagtata cttattctca agcaggagaa attgaggtga
     1741 ttgactatag atgctcttta taataatttg aaaaatatta aataataatg gcaaagacag
     1801 tttatcttgg tatgataggc gatatcatgc acccgggtta cattaacatc attaacaaag
     1861 ctactgagta tggcgatgtg ataatcggtt tgttcactga taaggcgatt gctaaccacc
     1921 gtagacttcc ttatctcact tgggagcaaa gaaagaacgt tgttgagagc atcaggaacg
     1981 tatcaagggt ggtccctcag gatgattgga gctatgtctc taatctcctt aagtacaagc
     2041 ctgattacat cattcatggc gacgattggc tggttggccc tgacaagtat atccgtgatg
     2101 aagtattcaa ggtaatggaa aagttgggtg gtgaggttat cgagattcct tatacccaaa
     2161 atatctctgc ttctggcatc aagcaggaga ttgatactct tggcgtaact cctcagatgc
     2221 gtctttcttc tctccggcgc cttattgctg ctaaaccgat tgtacgtatt cttgaaagtc
     2281 acaatggtct tactggccta atagcagaac atactaaggt agaggtagat ggtcaggagc
     2341 gtgagttcga tggcatgtgg gcttcctccc ttaccgactc tacctctaag ggtaagcctg
     2401 atattgaggc tgtcgatttg actacccgtc tccatgacct caatgatacc cttgaagtaa
     2461 ccacaaaacc tgttatcttc gatggcgata ctggtggcaa gattgaacac ttcggtttta
     2521 ccgttcgcac ccttgagcgc ttgggaatct cttgcgttat aattgaagat aaggtaggct
     2581 tgaaacagaa ttcacttttt ggtactgatg ctgtacagac tcaggataca atcgaaggct
     2641 ttcaggctaa aatccgtgcg ggtaaggagg cgcagattac tcgtgacttc atgattgtca
     2701 gccgttgtga gtctctcatc gctggtaaga ctgtagatga tgctttggag cgttgtcatg
     2761 cttacgtaga ggcaggtact gacggtataa tgatccactc caaagagaag tcaggagagg
     2821 acatcaagga gttttgtttc cgttttcgcg agaaagatgc tcatactcct atcatcgttg
     2881 tgcctactac ttataaccag ttcacagaag aggaacttgc tgaatggggt attaatgtag
     2941 tgatttatgc taatcacatg cttcgttctg cttatcctgc aatggttaaa tgtgcagaaa
     3001 ccatcctcta tactagccgt tcgcttgaag catctgagca gtactgtatg cctatcaaac
     3061 agattcttaa tcttattcca ggcacaaaga agaagtaaac attaatttct taccccttaa
     3121 actattttac aaatggtaag acccgaattt tttgtaaata tactcaagga acaaggcata
     3181 gacttttatg ctggtgttcc tgattcgttg ctcaagaaca tttgtgcata tattaccgac
     3241 caccttcctg ctgagcagaa tattattgct gctaacgaag gaggggccat gggtattgct
     3301 gtaggttatc atttggcaac aggtaaggtg tctgtagttt atatgcagaa ctctggtgaa
     3361 ggcaatatca ttaatccgtt tgcctctctt accgacaagg acgtttataa cattcctgtg
     3421 ctcctcgtta tcggttggag agggcgccct ggagttcacg atgaacctca gcatgtgaag
     3481 caaggtaagg tgacaatcgg tttgcttaat accatgggta tcaactatgc tattctgcca
     3541 aaggatgaag agggagctgc aaagcagata aaaatagctg tcgacttcat gaaggcaacc
     3601 aacgagtgct atgcccttgt gatagagaag gatactttcg atacctataa gcttcagagc
     3661 gttgaggtaa acgaactggc aatgtctcgc gaagagacga ttcagaaggt ggcttcaaac
     3721 attgaagata atgcttgtat cgtatcaact actggtatga tttctcgcga gctctttgag
     3781 gcacgtactg cttggagcca aggtcatgaa cgtgatttcc ttactgtagg ggcgatgggc
     3841 catgcttccc agatagctct cggcatagct ctccaaaagc ctgagcgtcg agtatattgt
     3901 tttgatggtg atggagccag catcatgcac atgggtaata tggctattac agccagcatg
     3961 aaatgcaaga attatgtgca cattgtgttc aacaatggcg cacacgattc tgttggtggt
     4021 cagcctactg ttggtctcaa gattgatttt tgtgcaattg ctcaagccgt aggttacaag
     4081 gctgcttata gtgtagaaac tatggaggca cttgaagcaa aacttgcaga attcaagaac
     4141 gcagaaggtc ctgttttcct tcagatttgc gtaaaaaagg gaaaccgcaa ggaccttggt
     4201 cgtccaacta caactcctat tcagaacaaa gaggctttta tggaatttct taacaagtaa
     4261 agtatgaaag taattctgtt tgctgatata cacgccaatc tttctgcttt tgaggcggtt
     4321 ctagttgata ttgagaaaca ctatcagcca gatgccatga ttagtctagg tgactttatc
     4381 gactatggta tgcgttcaaa tgaaattatt gaacgtatac aaactgttaa tattccatta
     4441 cttgccaatt tgaagggtaa tcacgagaag gctttgattg atggggaact ctcatgtttc
     4501 tcttcagaaa gagctcgtgt gatgtccaaa tacacaagaa accatctcac tcagacatct
     4561 attgattata taagcaatgt gatgcaagag ccaatgcaag agttggaaat tggtggtaag
     4621 aaagtacttc ttttacatgg aactattgat gatccctatt ggggaaaact gactccagca
     4681 aaagtggaag atgaaaagta tcaggatttt gactacgtat tgagcggtca cattcatcaa
     4741 ccttttaaga tagatgtatt cttcaaagtt gacaatccaa tcatgcgcaa tcagaaacgt
     4801 acgactttta tcaacccagg ttcagttgga caacctcgca atcagaatcc atatgcacaa
     4861 tatgtgtata tcaattttga aacgggggaa acccatttca atgcagttcc ttacgatatt
     4921 gaagctgaac aatctctttt ccccaaagag atagatactt tttacagcga acgattaaaa
     4981 tttggaatat aaatgaagaa cttatatgta ataagtggtg ttactggcat gacgggtagt
     5041 gaactgtctc gtcagtttgt ttctcagggt catacggtaa tcggtttcga caacttcttt
     5101 gcaagttcta ttgataccgt taaagacatt attgacaatc cctcgttcat cttctataat
     5161 tacgacatta acaaagtcgc tcagatggat gaagtatgcg ataaggcgaa agaactcaaa
     5221 attgagtgcg atggtcgtct ggtgtttatc aattgtgctg ctgttgtcca tacaaagcat
     5281 ttctatgagg tagagagtac ttttcagact aacgtccttg ctatgaagga tttcttggag
     5341 cgtgccattt ctatgagggc tgatacttac attaattgtt caacttcgga ggtttactca
     5401 atgcagtctt ggaatgagaa tggcggtgtg aaagaatctg attatttggc aatgtcaaca
     5461 gcggaacata gccaacgtac aagttatgct tgcggcaagt tgatgactga attctttatg
     5521 aaagatgctg ttggcaaggg acgaattaaa ggttgttcta ttcgctttgc taatgtatat
     5581 agcaggcacg agcgttttgc agagcacatt atccctcata tcattgataa tctgcttgaa
     5641 agccataccg taacccttct tgaaaactcg aaggtgaaca aacgtacctt ccttcataat
     5701 attgatagct gtcgtgccgt tatggagctc atcgcttctg aggatgctct tgatggtact
     5761 gtttataatg tggctactga agaggaaatt gccattattg atctagtcaa gacgattgca
     5821 ataaaaatgg gcatcaacga tgtggatatc cgtttcgaag gttaccgaaa gtctgatcct
     5881 gagcgtcgat tgctcaatac ggacaagatt cgtacccgta ctagctggaa acctatcatc
     5941 actctcgatg aaggcctcac gatgtgtgta aatagtatca agaaatgaaa tatttgatta
     6001 taactgttgc tggaacggct acgcgtttta atcgcgacac taaggaagaa accctcaaat
     6061 gcttgtatta taccgatgaa cctcaatacg ctcttcttgc tcaattgctg aagaattgtg
     6121 gtgagtacga taaatatatc cttgtggggg gctaccttta tgagaagttg ggaagatttg
     6181 taaagaacga actctctggt tatggcaaaa aaatagaact tgtttacaac gagcatttca
     6241 aagactatgg ctccggctac agtttataca aaggtataga ggcaataaag gaggcaggtg
     6301 atgtgacttt cgtagaaggc gacttgttct ttatggctac agatttcagg caagtgtata
     6361 attcgccaaa gagtgtgatt accattaacc gagaaccaat ctactcgaat aaggcagttg
     6421 cgttatacat taacgttgat ggcaaaccaa ggtatttata tgatacgaac catcagacat
     6481 tgactgtatc agagccattc aaggcaatct tcaacagtgg tcagatgtgg aaattttctt
     6541 catctgagag gcttttgaag actgttgatt cgcttacaaa agaacaactt caaggtacta
     6601 atcttgaaat aattcaggct tactttagtg atatgaatag tgaagagtat gatgtagtga
     6661 ctttcactga ctggttcaac tgcaatactg ttgcagatta tgatattgta agaaaattga
     6721 tgtaaaaatg aatatggctg tattagaaag agattacaga atagatggaa taaagtggtt
     6781 gctcattgta ttggttacat tcggtcatgt aatagaacct gctttaagca atcctattgc
     6841 caataagctc tattctataa tctacatttt tcatatgcca ttattcgtct ttatcagtgg
     6901 ttattatgca aatgttaagg ataaagaaaa actgattagt aaaggtttta tgcttttgga
     6961 aacatttttg gttgtgatga ttcctcaatg tttttattat ggaagtatca tccctttact
     7021 aaatccgaag aactcaggct ggtatttaat cagcctaata acttggtata ttatttttct
     7081 gttgattatc aataagctag ttggcaaaat tgtcgtacaa tataatgggt gcggggggca
     7141 gttattgata ttcagttgct tgttggccgt atttgcatac atgcttccgt tgaaacaatt
     7201 tggtaacctg ttatcgttcc aacggtcgtg tatgtttcta ccattcttta tgatgggttt
     7261 cttgagaaga gtaaaaggcc tgcctattat tcctgatgtt tcaaaatgca taaagcttgt
     7321 tttggctata gcctctttag tatgttttgc tttttgtctc atctatagtg gccgtatact
     7381 acatgtatta gagtttaata atgccaatgt gtggcacatg tcaaatttgt acaatcaaaa
     7441 tataggaatg cttcttgttt tgaaagtatt ggtttatatt ggatcaatta ttactacatt
     7501 cgctgtttta atgtttgtga acctccccaa gtcgatatgt gcttatggat caaagacttt
     7561 agcatattat gtaatacaag gcatgtttgc acacatatta tcaacctatt tgcaagttaa
     7621 tttttaccag gccttgtttc tctgtgtttg catattagtc cttacaacag ttctattacg
     7681 atttgttgat tctaaattta ttacaaaccc gttttctact ttattaaaat ggaaatactg
     7741 aacagaaaac tttcccttct caaagggaag gttgaaaata gtcagccaat aactattatg
     7801 attattggtt tgggtagcgt tggatgctac ttgttggatt atcttgtatc actaggtgat
     7861 tcacaacttc gtcttgttgt ggtaggacgt aatgcagaaa agatgcagat ggatataaat
     7921 attattcgta ctgcttcaac cattcgtcac cagtgccgta gcgagattaa ggtggttgat
     7981 aactgcgacc ttaacgatgt gaacagcatt gcagctgtac ttgaagcaga aaagcctgac
     8041 ttcatagtaa atagtagtcg agtttactct ggtttgaagt atggtagcat ctcatggagt
     8101 aatcttcgtg catacggtat ttggactccg ctttctattc gatatgcaaa gaatataatg
     8161 gaggcatacg ataaggccaa ctgtgaggca atctcaatca atacttcata ttccgatgct
     8221 gtcattcctt ggctaaagtc tgcgggtaag gcttattttg actttggtag tggtaatttg
     8281 aatcatcttg tgcctcgtat aaaattctat attgcagaga aatatggtat aaagaatttt
     8341 aatgacattg atgtaactat tgcggtatca cattttcatg atgttgtcat ttctaaggaa
     8401 ggtcatgcag aaggtcagga catcttgctt gatataaagt ttcaaggcaa ggatatggat
     8461 tttaataagg aagaacttct taaatcctgt tctatagcaa tgcctgtaga tcagaagcgc
     8521 aatatgatga atgcttccag taattttgat atcatattct ctgtgcttac tgctcttcga
     8581 gaggaaaaac aagtcaaaat acatactcct ggggtaaatg gtgaaattgg tggttatcct
     8641 ataattattg atggagtaac tgctactgcc aagtttgatg agtctgtatg gactatagac
     8701 cagatgcgta aagctaaccg tgagtcaatt tattgtgatg gagtagagaa tataactgac
     8761 gctactctcg tctatactga tgaacttgta gctaaggtaa agaagtcgtt taatgttgat
     8821 ttgcctaagt cggtaaagtt tgtggatatt gaaaatgtag cagatttaat tatcaatcag
     8881 ataattaaac ctcaagtgtt tgtttttgtg caataatttg taaactaatg gc
//
