LOCUS       c00273_gnlPro..        13460 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PKJABHOB_273.
ACCESSION   c00273_gnlPro..
VERSION     c00273_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 08:35:18
            Original ID  :: gnl|Prokka|PKJABHOB_273
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13460
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13460
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1368:4461]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1369..4461
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13460
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13460
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             135..1037
                     /locus_tag="ctg273_1"
                     /transl_table=11
                     /translation="MRLETCCNRQIDCMVCPQKSEGVLVYRHYPKGQHFSAEKCTQNCM
                     IFMLKGELLVNSDEYPGTTLQSRQLILQAIGSKVELLALTEVEYIVYWFTELPLICEER
                     YKEILKRSEAPLTYTPLTAISMLEGLLKSLACYLNEQPYACSKYIEMKCQELVYILTCY
                     YPLHQISTFFYPISTYTESFQYFVMQNYDKVKNVEEFAHLGGYTTTTFRRLFKNMYGVP
                     VYEWILDKKREGILNDLQYTKQRISVISARYGFDSLSHFAHFCKDSFGDTPRALRKRSA
                     NGEKISIICKEQGKDQEDE"
     CDS             1200..1367
                     /locus_tag="ctg273_2"
                     /transl_table=11
                     /translation="MWLSNSSVGRKVVMSVTGIALYGKAQDCGMGFSEHARTGYHRNRG
                     FGPAPGKLLG"
     CDS             1369..1689
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg273_3"
                     /sec_met_domain="SucD_FumR (E-value: 2.2e-67, bitscore:
                     216.5, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLPELMHNMGMHADTLTLAYAANGVYHIQNTFSNPVFVVLYLVW
                     LGALWFHLTHGFWSSMQSLGWNNKVWINRWKCISNIYSTIVVLCFALVVVVFFAKSLCG
                     AC"
     CDS             1726..3672
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 201; E-value:
                     1.2e-61)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg273_4"
                     /sec_met_domain="FAD_binding_2 (E-value: 3.1e-62, bitscore:
                     201.0, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.3e-37,
                     bitscore: 118.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKIDSKIPEGPVAEKWTNYKAHQKLVNPANKRRLDIIVVGTGLA
                     GASAAASLGEMGFRVFNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTVKG
                     GDYRAREANVYRLAEVSNNIIDQCVAQGVPFAREYGGTLDNRSFGGAQVSRTFYAKGQT
                     GQQLLLGAYSALSRQVNVGTVKLYTRYEMEDVVLIDGRARGIIAKNLVTGKLERFAAHA
                     VVIATGGYGNAYFLSTNAMACNCSAAMACYRKGAWFANPAYVQIHPTCIPVHGDKQSKL
                     TLMSESLRNDGRIWVPKKLEDAKKLQEGTLQGKDIPEEDRDYYLERRYPAFGNLVPRDV
                     ASRAAKERCDKGYGVNNTGLAVFLDFSEAINRLGKDVVAQRYGNLFDMYEEITDVSPYE
                     NPMMIYPAIHYTMGGIWVDYELMTSIKGLFAIGECNFSDHGANRLGASALMQGLADGYF
                     VLPYTIQNYLADQITVPRFSTDLPEFAAAEKAVQDKIDWMMNIKGKKSVDSIHKELGHI
                     MWEYVGMGRTAEGLKEGLKKLKEVRKEFEKELFIPGDKEGMNVELDKAIRLYDFITMGE
                     LVAYDALNRNESCGGHFREEYQTEEGEAKRDDENYFYVACWEYQGSDEKEPVLLKEPLV
                     YEAIKVQTRNYKS"
     CDS             3706..4461
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg273_5"
                     /sec_met_domain="Fer4_7 (E-value: 1.4e-12, bitscore: 38.3,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_3 (E-value: 4.4e-26, bitscore: 81.2,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 5.2e-07, bitscore: 20.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKNISFTLKVWRQKGPKAKGAFETYQMKDIPGDTSFLEMLDILN
                     EQLISEGKEPVVFDHDCREGICGMCSLYINGHPHGPATGATTCQIYMRRFNDGDTITVE
                     PWRSAGFPVIKDLMVDRTAYDKIMQAGGYVSVRTGAPQDANAILIPKPIADEAMDAASC
                     IGCGACVAACKNGSAMLFVSAKVSQLNLLPQGKPEALRRAKAMLSKMDELGFGNCTNTR
                     ACEAECPKNVSISNIARLNRDFIIAKLKD"
     CDS             4986..5807
                     /locus_tag="ctg273_6"
                     /transl_table=11
                     /translation="MLQMAKNKYSVETLRELNVSYDHEHGLTQKDVDMANSYVELIEQT
                     RSEITPQIGDRLIYVTEDGDYYGNALIENLHHTNKGHLSICEQPSIPFVWNDNGNIRLS
                     VSGGAFHAVNPKELKFLKWTDGSFKDWGHCRACANGAVAFYAKVPMWFYSEPNPKYGNF
                     TTETYRKFYFNKKEESEAGNLYQGFDIAFRNEAELQQFVEDYEGTIFKGNWPTQIVLWC
                     FRREYIFLPLPEWEKIESPAVERRLNFHPEQVKIVKDMEQHITYLYRIKNF"
     CDS             5827..6768
                     /locus_tag="ctg273_7"
                     /transl_table=11
                     /translation="MQTTTATKVGNAPDLLSGILSVQVRNEDKITEQDRLYCQTQQDLL
                     YRTLDQIDRWYAVFKEDAEQYQAERKFHYEDNGKVSMRDFYSYHNGRDDYSHNEFNPFD
                     LINDLVDKNRNANSNFAGRIISYFNNTYNVQVPVPNIDGKTLRMGFRPVYETYVDAVIE
                     HLGGKSFRETAEEELLSRVQKVVKPAYWTKVKTELKKDKIIFPEIIRFDDFSMQYSNRC
                     RVSYSYTNELETLCAGIAFGADDILNGNSKMIICFDDNNVSINDWYDLTTTNAEQIRFY
                     KNGRIDVRFKDSAAAESCFKRLRLDEITLREQ"
     CDS             6850..9852
                     /locus_tag="ctg273_8"
                     /transl_table=11
                     /translation="MYAIIPQQIPQDKRAEVNEKILFAIDSGKDLIPAESIYNCYTGIG
                     GLHNLKQSDFANYNEYANAKKEFEMGQFFTPHEVCRDMVEMLSPVYSEMILDMCCGMGN
                     FFNHLPNLHNAYGFDIDGKAVTVARYLYPEARIEKCDIRQYHPEQRFDVIIGNPPFNLK
                     FDYKLSQEYYMNKAYDVLNPAGILMVIVPLSFMQSEFWEKSRVANINSDFSFVGQVQLD
                     PNAFASTGVHNFRTKVMVFLRESRHIEMQPYNAEEFISMDELKGRIMEARAMKHKLRLD
                     LMRETNRIDREELELFEYKLAKYMYELKAHAALNRHIDKAEALVTKFRNQKPPENATKE
                     QEKEWERKKLTTKKVLGIIRRYITSQNIVPRKEVALVKTSYGFRLKQYAPRLLDKVQHK
                     AAGINDLVLGRAELPVPEILTEKNMMQVRAAKKLIRKKRRQYEIQNRPFSDMKPDTQLA
                     EYLDRTTFINKEGDVCEFTELQKHDLNLVLQKRFALLNWQQGSGKTAAVYHRAKYLLKY
                     RKVRNVIILAPAIATNMTWVPFLTINRERFRMVRNNADLETVPEGVFLVLSTSMLGKLK
                     RGLTKFIRRTSRKLCLVFDESDEITNPSSQRTRHILGIFRRLKYKILDTGTTTRNNIAE
                     LYSQFELLYNNSINMICWCSRIYHENRDREIEEDPNPHYGEPFPAFRGHVLFRACHCPG
                     KATVFGIEKQNQDVYNKDELSELIGKTVITRKFKDFAGEKYEVRMHTVAPSEGEHEVYR
                     VIIEEFCRICELYYNSTGDTKKDAGLRLMRQIKLLIKACSVPHLIEGYFGNGYPNKTVF
                     IEKLIRKIPGKVAVGCTSIAAFELYENLIRERFPDRPVFTVKGDVAFKKRQGIVSEFDS
                     TINGILVCTQQSLSNSVNIPSCNDVILESLQWNIPKMEQFYFRFIRLDSKELKNVHFVT
                     YKDSVEQNLMALVLTKERLNEFIKTGEVKEQSEIFEEFDVTMSVIDSLLVRERDSEGKI
                     HISWGSQRIMS"
     CDS             9857..10090
                     /locus_tag="ctg273_9"
                     /transl_table=11
                     /translation="MSTDTGNRRIHSTGKGSPYPHRLCKVMPRAVSGEIILAGGCGISP
                     ENPAQPGYGPFGACGMESPVPVINYNKKRLWT"
     CDS             10081..10578
                     /locus_tag="ctg273_10"
                     /transl_table=11
                     /translation="MDLNQAEVAVTTQHLIDIRQEKDNWLQMSDFGDMGEFLCTCSDMF
                     PEEENPEYRYTRWEEIPGSLINRQWLCPNFFEIREAMEQLDEPDKEWFFDWCDKCHHDI
                     SSEDPHLLVAHYLELYGNATSTGDDTCPDGDDDGFLYYPGISNNYFDTVTPRFEVFDDN
                     YD"
     CDS             10591..10905
                     /locus_tag="ctg273_11"
                     /transl_table=11
                     /translation="MNINFLGPVFPTDPYAQMAFVEILNTLLVANNIMEVNRMLIHRNA
                     NPAYGSLSGYFRWSYAGNHFTLWQRVEYNSPVCFGQRIFSIHFGMLASRDRERDSPTLN
                     "
     CDS             10916..11203
                     /locus_tag="ctg273_12"
                     /transl_table=11
                     /translation="MNTITIENREIAIMAFDKLCRENKKDSALRLAGCMLKHSYISLGI
                     GDIDWEIDMAIRQCGGEPRTGYRYTARFHFNLKTEMEKEKYDRAVKELYG"
     CDS             11296..12225
                     /locus_tag="ctg273_13"
                     /transl_table=11
                     /translation="MDEQKTLTLDFVKSLMEPAYTLVWTDYNDNLDDHRGLIQKCLDNK
                     NCEELWEKADEWYSDAEWEAVREIIAKLKEGCTVSGDFDEEDVDDFFDGHEDEIRDEIY
                     NRNDSDVLKDLIKRTDDIPIRVEMLSNYDCINSNWFESQGGYRYEESYFGDMVDTLNLN
                     PAKVKKLLLEHGYEVHERFPNRKSRDGKEQVSYEQFYQELVNSCCGANLLTYIGKVNLK
                     ELYDAGFSLKEIVIPKGNCCGLFSSMYGGGSLLEMELKQDVRLKLEVKDYHGFHFRLDD
                     ERSKYDYSVQHVYGVCDSFFGDAVSIVS"
     CDS             12266..12775
                     /locus_tag="ctg273_14"
                     /transl_table=11
                     /translation="MNTHLTIIRSHGKEHLCYRDEECFADVSLPMMTFTEGEDDFEIVK
                     CNRPVAGRTFRYQDGHFSIAMEMYPNGWPALCLKAPETHEIYTILTVNLENEPAFALPD
                     RAFVDINNNPDAMEFLIANKLAEDTGYKRQSGWVDYPMVKLNMPSLYRLDPAGFHKIIS
                     CQQINH"
     CDS             12795..13379
                     /locus_tag="ctg273_15"
                     /transl_table=11
                     /translation="MAKYDVKVRYAFEGTYTVVAEDRDQAERMVTEDCGLVLGGNIHTT
                     CGDDEVTDWNFDCHPDVQVLSFKERSKKGRAKYTAMDFSGRIEELRKDIIEAICQLLYA
                     HGLTELTFTSQDEDPVWVIWFNDDGEPYECWVNGIEATDNKLTVLATIKDSLEEVTCES
                     PFELGASNIDWLNEMYEAAKLELEGTKNVEP"
     CDS             13391..13459
                     /locus_tag="ctg273_16"
                     /transl_table=11
                     /translation="MKYQAGNAVSSFFYYMWNAWSKE"
ORIGIN
        1 aaatatacaa aaaaaatagc ctttttcata agtcctttat attagtttga cgcaaagata
       61 ggacaaatag atagagtttt cataaaaaaa ttctatcttt gttgccacat ttataataat
      121 tcgctaatca tttcatgaga ctggaaactt gctgcaaccg acagattgat tgtatggtat
      181 gtccccaaaa atcagaagga gtattggttt accgccacta ccccaaggga caacatttct
      241 ctgctgaaaa gtgcacacag aactgcatga tatttatgct gaaaggtgaa ttacttgtaa
      301 acagtgacga atatccgggc accactctcc aaagccgcca gctcatcttg caagccatcg
      361 gctccaaagt agaactcctg gctttgaccg aagtggaata tattgtctat tggttcaccg
      421 agcttcctct gatttgcgaa gagcgctaca aggagatact gaaacgctcg gaagccccct
      481 tgacttatac cccgcttacc gcgatttcca tgctcgaagg gctcctgaaa agccttgcct
      541 gctacctcaa cgagcaaccc tatgcgtgca gcaaatacat tgaaatgaaa tgccaggaat
      601 tggtatacat attgacatgc tactatccgc tacaccaaat cagtacattc ttctacccca
      661 tcagcactta tacggaaagc ttccaatatt tcgtcatgca gaactacgac aaggtgaaga
      721 atgtggaaga gtttgcccac ctcggtggat ataccaccac cacattccgc cgtctgttta
      781 aaaatatgta tggggtcccg gtctatgaat ggattctgga caagaaacgt gaaggaattc
      841 tgaacgacct gcaatacacc aaacaacgca tttcagtcat cagcgcccgc tatggctttg
      901 attccctatc ccactttgcc cacttctgca aagactcttt cggagacacg ccccgcgccc
      961 tgagaaaacg ttcggcaaac ggagaaaaga tttccattat ctgcaaagag caaggcaaag
     1021 accaggagga cgagtaaacc ttttacttgt ccgtaaactt cgcattctgc cggattacgg
     1081 aattatttct ttaatcgctt gctttatcgc tggatttctc ctatttttgc gaaacattta
     1141 cagaagtatc ctgatagaac aaattttcaa actattaaat aacttaaatt caatcattta
     1201 tgtggttaag taattcatct gtaggaagga aagtggtgat gagcgttacc ggtatcgccc
     1261 tttacggaaa agcccaagac tgtggaatgg gcttctcaga acatgctcgt actgggtatc
     1321 atcgtaatcg tgggtttggg cctgcacctg gtaaacttct gggctaaaat gcagcttccc
     1381 gagttgatgc acaacatggg catgcatgcc gacaccctca cgctggcata tgcagccaac
     1441 ggtgtctatc acattcaaaa caccttcagc aatccggtat tcgtagtgct ttacctcgtt
     1501 tggctgggcg cattgtggtt ccacctcact cacggtttct ggagctccat gcagtctttg
     1561 ggctggaaca acaaagtatg gattaaccgt tggaaatgta tctccaacat ctattctact
     1621 atcgttgtcc tctgcttcgc tctggtagtt gtcgtattct ttgcaaaatc attgtgcggc
     1681 gcttgctaaa ttcaaattgt aaatgactaa attgtaaatt gcattatgac taagatagat
     1741 tctaaaatac cggaaggacc ggtggctgag aaatggacca attataaggc tcaccaaaaa
     1801 ttagtaaacc ctgccaacaa acgtcgtctg gacatcatcg tagtaggaac cggacttgcc
     1861 ggtgccagtg ctgccgcctc tctgggcgaa atgggtttca gagtattcaa cttctgcatc
     1921 caggactctc cgcgccgtgc acactccatc gctgcacaag gtggtatcaa tgctgctaag
     1981 aattaccaaa acgacggtga ctctgtatac cgtctgttct acgatacagt aaagggtggc
     2041 gactaccgtg cccgcgaagc taacgtttac cgtctggctg aagtatccaa caatattatc
     2101 gaccaatgcg ttgcacaagg tgttcctttc gcccgcgaat acggcggtac actggacaac
     2161 cgttctttcg gtggtgctca ggtatcccgt actttctatg ccaagggtca gaccggacaa
     2221 cagctgttgc tgggtgcata ctctgcattg agccgccagg tgaacgtagg cactgtgaaa
     2281 ctgtataccc gctacgaaat ggaagacgtt gtcctcattg acggacgtgc ccgcggtatc
     2341 attgcaaaga acctcgttac cggtaaattg gaacgttttg ccgcccacgc tgtggtaatc
     2401 gctaccggtg gttacggcaa tgcctacttc ctttctacca atgcaatggc atgtaactgc
     2461 tctgcagcaa tggcttgcta ccgtaaaggt gcctggtttg ccaaccctgc ttacgtacag
     2521 attcacccca cttgtatccc ggttcacggt gacaagcagt ctaagctgac tttgatgtcc
     2581 gaatctctgc gtaacgatgg tcgtatctgg gttccgaaga agctggaaga tgccaagaaa
     2641 ctgcaggaag gtacactgca aggaaaagat attcccgagg aagaccgcga ctactacctg
     2701 gaacgccgtt atccggcatt cggtaacctc gttccgcgtg acgttgccag ccgcgcagcc
     2761 aaagaacgct gcgacaaggg ttatggcgtg aacaacaccg gccttgccgt attccttgac
     2821 ttctccgaag ctatcaaccg tctgggtaaa gatgtcgttg cacaacgtta cggcaacctc
     2881 ttcgatatgt atgaagaaat cactgatgtc agcccatacg aaaacccgat gatgatttat
     2941 ccggctatcc actataccat gggcggtatc tgggttgact atgaactgat gacctccatc
     3001 aagggtctgt tcgctattgg tgaatgtaac ttctccgacc acggtgcaaa ccgcctcggt
     3061 gcttctgcgc tgatgcaagg tctggccgac ggttacttcg tattgcctta cactatccag
     3121 aattacctgg ccgaccagat tacagttccc cgtttctcta ccgacctgcc cgaatttgca
     3181 gctgcagaaa aggctgttca ggacaagatt gactggatga tgaatattaa gggtaagaag
     3241 tctgtagact ctatccacaa ggaactgggc cacatcatgt gggaatatgt aggcatggga
     3301 cgtacggctg aaggcttgaa ggaaggtctg aagaagctga aagaagtccg caaggagttc
     3361 gagaaagaac tgttcatccc gggcgacaag gaaggtatga atgtagaact cgacaaggct
     3421 atccgtctgt acgacttcat cactatgggc gagctggttg cttacgatgc actgaaccgt
     3481 aacgaaagct gcggtggtca cttccgtgaa gaatatcaga ctgaagaagg cgaagccaag
     3541 cgtgacgatg aaaactactt ctacgtggct tgctgggaat atcagggttc tgacgaaaag
     3601 gaaccggtat tgctgaaaga gccgctggtt tacgaagcaa tcaaggtaca gactcgtaac
     3661 tacaagagct aatcgggaag ttgaacattt aaagaattaa agaaaatgga taaaaatata
     3721 tcatttacgc tcaaggtatg gcgccagaag ggtccgaaag caaaaggcgc ttttgaaaca
     3781 taccaaatga aagatatccc gggcgatact tcattcctcg aaatgctgga tatcctgaac
     3841 gaacagctga tttctgaagg taaagaaccg gttgtattcg accacgactg ccgcgaaggt
     3901 atctgcggta tgtgttcgct ctacatcaac ggacaccccc acggtcctgc aaccggcgct
     3961 actacttgcc aaatttatat gcgtcgtttc aacgacggcg ataccatcac tgttgaaccg
     4021 tggcgctctg ccggtttccc ggttatcaag gacttgatgg tcgaccgtac ggcctacgac
     4081 aagattatgc aggcaggcgg ctacgtcagc gtacgtaccg gtgctcccca ggatgccaac
     4141 gctatcctga ttccgaagcc catcgctgac gaggctatgg atgctgccag ctgtatcggt
     4201 tgtggtgctt gtgtggctgc ttgtaagaac ggttctgcta tgctgttcgt ttctgccaag
     4261 gtgagccagc tgaacctgtt gccccaaggc aaaccggaag cattgcgccg tgccaaggct
     4321 atgttgagca agatggacga actcggtttc ggtaactgta caaacactcg tgcgtgcgaa
     4381 gctgaatgcc cgaagaatgt ttccatcagc aacattgctc gcctgaaccg cgactttatc
     4441 attgcgaaac tgaaagacta atccggtctt tctgcaaata atataggatg cgcttcggat
     4501 aaaccttttg agcaagctca gatttatcac tcagcttcct ctatatttgt gatagtgtga
     4561 agtattttat ttgactatca acgatttgta gtaaactcgc atgagaacgg gcaacggata
     4621 agaaaatgcc ggattgttca gaaccaccat gttcctcatg ctttcaaata actcttttat
     4681 caatgcaaag atagcatttt ttctgtaaag gccggtaata atccggtcaa aatcttatga
     4741 aatagtccta tcggaaagag ctgccatccc gtagccgagt ccccgtaact cacaggcaaa
     4801 ggtaattcgt gttcttttcg tacaagcaag gtcaagccct tcgggttccg tggaaaaatc
     4861 ttccgcgccc tgaagggctt gcggtatttt tcccggaaac cttgcatgta cggaacacga
     4921 ccttttaagc ctgtagttac gggaactccg gccccgaaaa gccggactaa caaaaatcaa
     4981 atgttatgtt acagatggct aaaaacaagt acagtgtgga aacactcaga gaactgaatg
     5041 tttcatacga ccatgaacac gggctgacac agaaagatgt cgatatggct aacagttatg
     5101 tggaactcat cgaacagaca cgttccgaaa tcacaccgca aatcggagac agactgattt
     5161 atgtgaccga agacggggac tattacggca acgcccttat agagaacctg caccacacaa
     5221 ataaagggca tctttctata tgcgaacagc caagcatacc tttcgtctgg aatgataacg
     5281 gaaatatccg gttgagcgtc agtggaggtg cgtttcatgc cgtgaatccg aaagaattga
     5341 aattcctgaa atggacggat ggttcattca aggactgggg acattgtaga gcttgtgcaa
     5401 acggagcggt ggcattttac gcaaaagtac cgatgtggtt ctattcagaa cccaatccca
     5461 agtacggaaa tttcacgacc gaaacctacc gaaaatttta tttcaataaa aaggaggaat
     5521 cggaagccgg caatctttac caaggttttg acattgcttt ccgtaacgag gcggaactgc
     5581 aacagttcgt ggaagactat gaaggaacga tcttcaaggg aaattggcct acacaaatag
     5641 tattgtggtg tttccgtcgc gaatatatat tcctgccgct tcccgagtgg gaaaagatag
     5701 aatcccctgc cgtagagcga agactgaatt tccatcccga acaagtcaag attgtcaagg
     5761 acatggaaca gcacatcacc tacctgtatc gtatcaagaa tttctaacat ctaaaatcca
     5821 ataaatatgc aaacgacaac agcaactaag gtcggcaacg ctcccgacct gctttccggt
     5881 atcctgagcg tacaagtgag aaacgaggac aaaatcacgg agcaagaccg cctctattgc
     5941 cagacacagc aggacctgct ctacaggacg ctcgaccaga tagaccgctg gtacgccgtc
     6001 ttcaaggaag atgctgaaca ataccaggcg gaacgcaagt tccattacga agacaacggc
     6061 aaggtatcca tgcgcgattt ctattcctac cataacggca gggatgacta ttcgcacaat
     6121 gagttcaatc cgttcgacct tatcaatgac ttggtggaca agaaccgtaa tgccaactcc
     6181 aacttcgcgg gtcgcatcat ctcctatttc aacaacacct acaatgttca agtgccggtg
     6241 ccgaacatag acgggaaaac gctccgcatg ggattccgcc cggtctatga aacatacgtg
     6301 gatgccgtca tagaacactt gggaggcaag agcttccgcg aaacggcgga agaggaacta
     6361 ctcagccgtg ttcagaaagt cgtcaaaccg gcatactgga ctaaggtaaa gactgaacta
     6421 aagaaggaca agattatctt ccctgaaatc atccgttttg atgatttttc catgcaatac
     6481 agtaatcgtt gtcgagtgtc atatagctat accaatgagt tggaaaccct ttgtgctgga
     6541 attgcattcg gtgcggatga catattgaac ggcaactcaa agatgattat ctgtttcgat
     6601 gataataatg tatccattaa cgactggtac gaccttacca cgaccaatgc cgagcaaatc
     6661 agattctaca agaacgggcg catagacgtc aggttcaagg acagtgcagc cgccgaaagc
     6721 tgtttcaagc ggctccggct ggatgaaatc acactaagag aacaataacg gcatgagaga
     6781 ccaatccaga caccccgtaa ggcatccttg cggggtgtct tcattttcaa acgtaaacaa
     6841 tccaaagaca tgtacgccat catcccccaa cagataccgc aggacaagcg ggccgaagtc
     6901 aacgaaaaga tacttttcgc catagactca ggtaaagacc ttattccggc agagagcatc
     6961 tacaactgct ataccggcat cggagggctg cacaacctaa agcagtccga cttcgccaac
     7021 tataacgagt atgccaatgc caaaaaagag ttcgagatgg gacagttctt cactccgcat
     7081 gaagtatgca gggatatggt ggagatgctt tctcccgtct attcggaaat gatcctcgac
     7141 atgtgctgcg gcatgggcaa cttcttcaac caccttccca acctgcacaa cgcctacggg
     7201 tttgacattg acggcaaagc agtgactgtc gccagatacc tctacccgga agcccgtatc
     7261 gagaaatgcg acatccggca ataccacccg gaacaacgct tcgacgtcat catcggcaac
     7321 cctcccttca atctgaagtt cgactacaag ctctcccagg agtattacat gaacaaagca
     7381 tacgatgtgc tcaatccggc aggcatcctg atggtcatcg ttcccttatc gttcatgcaa
     7441 agcgagttct gggagaagag ccgtgtcgcg aatatcaaca gcgacttttc ctttgtaggc
     7501 caggtgcaat tagacccgaa cgcctttgcc tccacagggg tacacaactt ccgcacgaaa
     7561 gtaatggtgt tcctgcgcga gtcccgccat atcgaaatgc agccctacaa tgcggaagag
     7621 ttcatctcca tggacgagtt gaaagggcgt atcatggagg caagggcgat gaagcacaaa
     7681 ctgcgcctcg accttatgcg cgagaccaac cggattgaca gggaggaact ggaactgttc
     7741 gagtacaagc tcgccaagta catgtacgaa ctgaaagcac acgcggcact gaacaggcat
     7801 atcgacaagg cggaagcgtt ggtgacgaag ttccgcaacc agaaaccacc ggagaacgcc
     7861 accaaagagc aggagaagga atgggaaagg aagaagctga ccacgaaaaa agtactcggt
     7921 atcatccgca ggtacatcac ctcacaaaac atcgtcccgc gcaaggaagt ggcattggtg
     7981 aagacctcct acggcttcag gctgaaacag tacgccccac gcctgctgga taaggtacag
     8041 cacaaggcag cgggcatcaa cgacctcgta ttgggacggg cggagcttcc cgtaccggaa
     8101 atcctgacgg aaaagaacat gatgcaggtc cgtgcagcga agaaactgat acggaaaaag
     8161 cgcaggcaat atgaaataca gaaccgtcca ttctcagaca tgaaaccgga cacacaactg
     8221 gccgaatatc ttgaccgcac gaccttcatc aacaaggaag gcgatgtatg tgagttcacg
     8281 gagcttcaga aacacgacct gaacctcgta ttgcagaaac gctttgccct gctgaactgg
     8341 cagcaaggct ccggcaagac ggcggctgtc tatcaccgtg ccaagtacct gctcaaatac
     8401 cgtaaggtgc gcaatgttat catactggcc cccgccatcg ccaccaacat gacatgggtg
     8461 ccgttcctga cgataaacag ggagcgattc cgcatggtca ggaacaacgc cgacctcgaa
     8521 acggttccgg aaggggtatt cctcgtgctt tccacctcca tgctcggcaa gctgaaaaga
     8581 gggctgacaa agttcatcag gcgcacctca aggaaactct gcctggtatt cgatgaatcc
     8641 gacgagatta ccaacccctc gtcacaacgc acaaggcata tcctgggcat cttccgcagg
     8701 ctcaaataca agatcctcga cacgggaacg accacgcgca acaacatcgc ggagctgtac
     8761 agccagtttg aactgttgta caataactcc ataaacatga tttgctggtg cagccggata
     8821 taccacgaga acagggacag ggagatagag gaagatccaa acccgcacta cggagaaccg
     8881 ttccccgcct tcagggggca cgtactgttc cgggcctgcc actgtcccgg caaggcgacc
     8941 gtgttcggca tcgagaagca gaaccaggac gtatataaca aggacgaact gtccgagctt
     9001 atcggcaaga ccgtcatcac gcgcaagttc aaggactttg ccggagaaaa atacgaggta
     9061 aggatgcaca cggtcgcacc atccgagggg gaacacgagg tgtaccgtgt tatcatcgag
     9121 gagttctgtc gtatctgcga gctttactac aacagtacgg gcgacacgaa aaaggatgcc
     9181 gggctccgtc tcatgcgcca gatcaaactt cttatcaagg cctgctccgt gccccacctg
     9241 atagagggct atttcgggaa cggctacccg aacaagacag tcttcatcga gaaactgata
     9301 cggaagattc ccggcaaggt tgccgtcggc tgcacctcca tagcggcgtt tgaactgtac
     9361 gaaaatctca tccgcgagcg tttcccggac cgaccggtat ttaccgtcaa gggtgacgtc
     9421 gcgttcaaga agcggcaggg catcgtttcg gaattcgatt ccaccatcaa cggcatactg
     9481 gtatgcacgc agcagagcct gagcaactcg gtaaatatcc cctcctgcaa cgatgtcatc
     9541 cttgaatccc tgcaatggaa catccccaag atggagcagt tctacttccg cttcatccgc
     9601 ctggactcca aggaactgaa gaacgtccat ttcgtgacct acaaggattc cgtggaacag
     9661 aacctgatgg cattggtact gacaaaggaa aggctcaacg agttcatcaa gaccggcgag
     9721 gtgaaggagc agtcggaaat cttcgaggag ttcgatgtca cgatgtccgt catcgacagc
     9781 ctgctggtac gggaacgtga cagcgaggga aaaatccaca tcagctgggg aagccagcgc
     9841 ataatgagtt agcaaaatga gtacagacac agggaaccgc agaatccatt ccacaggcaa
     9901 aggtagcccg tatccccatc ggctgtgcaa ggtcatgccg cgagcggttt ccggagaaat
     9961 catcctcgcc ggaggctgcg gtatttcccc ggaaaaccct gcacagccgg gatacggacc
    10021 ttttggggcc tgtggaatgg aatccccggt tccggtcatt aactacaata aaaaacgatt
    10081 atggacttga atcaagcgga agtggcagtg accactcagc atctcataga cataaggcag
    10141 gagaaggaca actggttgca gatgtccgac ttcggcgaca tgggggaatt cctttgcacc
    10201 tgctccgaca tgttcccgga agaggagaac ccggagtaca ggtacacgcg gtgggaagag
    10261 attcccggct cgctgataaa caggcagtgg ctgtgcccca acttctttga aatcagggag
    10321 gcgatggaac agctggatga acccgacaag gagtggttct tcgactggtg cgacaaatgt
    10381 catcacgaca tcagctcgga agacccgcac ctgctggtag cgcactacct ggaactgtac
    10441 ggcaatgcca cgtccaccgg cgacgacacc tgcccggacg gagacgatga tggcttcctg
    10501 tattatccgg gcatatcaaa caattacttc gacacggtca ccccccgttt cgaggtgttc
    10561 gatgacaatt acgattaaaa acatacgctt atgaatatca attttctcgg accggtcttc
    10621 ccgacagacc catacgcgca gatggcgttc gtggagatac tgaataccct tctggtggca
    10681 aacaacatca tggaggtgaa cagaatgctc atacaccgga atgccaatcc cgcgtacggc
    10741 tcgctgtcgg gatatttcag atggtcgtat gcaggcaacc atttcacgct gtggcagcgt
    10801 gtggaataca attccccggt ctgtttcgga caacgcatat tcagtatcca tttcggaatg
    10861 ctggcaagcc gggacaggga acgggatagt ccgacactta actgaattgg aatatatgaa
    10921 tacgataacg atagaaaaca gagaaatcgc aataatggct ttcgacaagc tgtgcagaga
    10981 gaacaaaaag gactccgctc tgcggcttgc cggatgtatg ctaaagcact catacatatc
    11041 gctcggcatc ggtgatatcg actgggagat agacatggcg atacggcaat gcggcggtga
    11101 gccgagaacc ggttacagat ataccgcccg tttccatttc aacctgaaga cggagatgga
    11161 aaaggaaaaa tacgacaggg ccgtgaagga actgtatgga taaggagatt tacacggagg
    11221 cggccgcaag gtcgcttccg tcatttataa cggtatgtac gggaaacaga atcctgccgt
    11281 acacaggtaa gacaaatgga tgaacagaaa acattgacat tggatttcgt gaagtccctt
    11341 atggaaccgg cctacacgct ggtatggacg gattataatg acaatcttga cgaccatcgg
    11401 ggcttgatac agaagtgtct tgacaacaaa aactgcgaag agctgtggga aaaggcagac
    11461 gagtggtaca gcgatgccga gtgggaagcg gtccgtgaga ttatcgcaaa attaaaagag
    11521 ggatgcaccg tatcgggtga ctttgacgag gaagatgtcg atgacttctt cgacgggcac
    11581 gaggatgaaa tccgcgatga gatatacaac cgtaacgact cggatgtgct gaaggacctg
    11641 ataaaacgca cggacgacat acccatccgg gtggaaatgc tttccaacta tgactgcata
    11701 aattccaact ggttcgagtc gcaaggcggc tatcgctacg aggaatccta tttcggggac
    11761 atggtggata ccctgaacct caatcctgcc aaggtcaaga aactcttgct tgaacacgga
    11821 tacgaggttc acgaacgctt cccgaacagg aaatcgcgtg acggcaagga gcaggtgtcc
    11881 tacgaacaat tctaccagga acttgtcaac tcctgctgcg gggccaacct gctgacctat
    11941 atcggaaagg ttaacctgaa ggaactgtat gatgccggct tctccctaaa agagatcgtc
    12001 attcccaaag gaaactgttg cggactgttc agttcgatgt atggcggtgg cagcctgctt
    12061 gaaatggagc tgaaacagga tgtaaggctg aaactggaag tgaaagacta ccacggtttc
    12121 catttccggc tggatgatga acgctccaaa tacgactact ccgtccagca tgtatatggc
    12181 gtatgtgatt ccttcttcgg tgatgcggta agcatagtgt cctgacagtc aaataaagca
    12241 ataactttat aaaacaattg tgaatatgaa tacccatttg acaataatcc ggtcacacgg
    12301 gaaagagcac ctctgttacc gtgatgaaga atgttttgcc gatgtatcct tgcctatgat
    12361 gacatttacc gaaggagaag atgatttcga gatagtcaag tgcaatcgcc cggttgccgg
    12421 caggactttt cgctatcagg acggacactt ctccatagca atggaaatgt acccaaacgg
    12481 ttggccggca ttgtgcctga aagctcctga gacacatgaa atctacacca tcctgacggt
    12541 caatcttgaa aatgaaccgg catttgcttt accggacagg gcttttgtcg acatcaacaa
    12601 caatcccgat gccatggagt tccttatagc caacaaactg gcggaggata caggctacaa
    12661 gagacagagc ggttgggtag actacccgat ggtaaagctg aatatgccgt cgctttaccg
    12721 gcttgaccct gccggatttc ataaaatcat aagttgtcaa caaataaatc attaacaatc
    12781 aaatcataag aattatggca aagtatgatg taaaggtaag gtacgccttc gaaggtactt
    12841 acactgtcgt ggcggaagac cgcgaccaag cagagagaat ggtaacggaa gactgcggtc
    12901 tggtgctggg cggcaatatc cacacgacct gcggtgatga cgaggtaacg gactggaatt
    12961 tcgactgtca tcccgacgtg caggttctgt ccttcaagga gcggagcaaa aaaggcaggg
    13021 caaaatacac tgccatggat ttcagcggca ggattgaaga actccgcaag gacatcattg
    13081 aagcaatatg tcagttgctc tatgcacacg gattgacgga actgacattc acgagtcagg
    13141 acgaagaccc tgtctgggta atatggttca atgacgacgg cgagccttac gaatgttggg
    13201 taaatggcat tgaagctaca gacaacaaac ttacggtatt ggccacgata aaggacagcc
    13261 ttgaggaagt tacctgcgaa tccccgtttg aactcggtgc aagtaacatc gactggctca
    13321 acgaaatgta cgaggctgca aagctggagc tggaaggaac aaagaatgtc gaaccttaaa
    13381 tctgaaaatc atgaaatatc aagcgggaaa tgcagtctcc agcttcttct actatatgtg
    13441 gaacgcatgg agcaaggaag
//
