LOCUS       c00519_gnlPro..         6168 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PKJABHOB_519.
ACCESSION   c00519_gnlPro..
VERSION     c00519_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 08:35:18
            Original ID  :: gnl|Prokka|PKJABHOB_519
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6168
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..6168
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[841:5071]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      842..5071
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..6168
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..6168
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(84..836)
                     /locus_tag="ctg519_1"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVAAL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             complement(842..1393)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg519_2"
                     /sec_met_domain="ALS_ss_C (E-value: 2.9e-20, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKH"
     CDS             complement(1426..3177)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg519_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.2e-48, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRKAAELI
                     NGAERPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             complement(3269..5071)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg519_4"
                     /sec_met_domain="ILVD_EDD (E-value: 1.2e-219, bitscore:
                     718.5, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQFVKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRKKLFEDAAKLIVENAFRYYEEGDESVLPRSIATREAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGADFKMDDIDMLSRKTPCLCKVAPNTQKYHVQDVNRAGGIIAIMDELAKGG
                     LVDTNVRRVDGMTLAEAIDRYSITSSNVCKEAIKKYSSAAAGKFNLVLGSQNASYKELD
                     TDRATGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQDA
                     ACDGILAGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIKDGDIIEIDIPNRSINVKLTDEELAARPMTPVTRNRE
                     VSKALKAYASMVSSADKGAVRLID"
     CDS             5561..6133
                     /locus_tag="ctg519_5"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYSIENGEKDFEEEAPVEHPFQFISGLGMTL
                     EPFEAQIKDLQIGDKFDFTIPASEAYGEYDDDHVIDLPKEIFMIEGEFDSDRVVEGAVI
                     PLMTSEGQRINGSVVEVKEDVVVMDMNHPLAGCDLNFTGEVVESRPATNEELAEVARMM
                     GGGCGSCGCGDCGDGCGDHECGGGCCH"
ORIGIN
        1 ctcaataaca ccgccaaaat tcaattgtgc cattttttgt tttaattttt atttgtggct
       61 tacgccaacg ttgataaatt tatttatttc tctgtaaata tcactttaga gcgacagacc
      121 acttcgctgc cattcttttt cacctccaca tcgtaaacgc cctcaccggc atcatccatg
      181 aacaaagtca actcatcccc ataatagctt tcggctacat atgccatttc aaaacgacgg
      241 atgcgcttct ccttatacat ctctatcggg aacaaatcaa ggatatgctc gatgtaacgg
      301 atgctgttca catgcccgtt aatgtcaata tcactgtatt tggctaccaa agcagcaacc
      361 ggttcctttg aggccacctt tatccgcgaa ggtttttcta tcgggcaagg ctcatcgcaa
      421 acataatcta caatgctgcc actatgaaga gccagcaaat ctgccggctt acgggtattc
      481 atgctaatca tcgcccaaac ggaacgtgca tacccaatct tcttgccctc cttatcgatg
      541 atagcgaaat tacggtctgt aaaaaggcga tagacattct ccacccaagt ctgaatggag
      601 aaatcttcgt actgataagg catttcatcc agttcgacag ccagacggga caatacccaa
      661 gtataattgt cctcgtttag agtcgcgatg ccaaaaccgc ggtcgctggc atggaaaccc
      721 gcacaattca acaaatggtt gcccaatact cccattgtca gccgtccggt aaagtcgaca
      781 tgaaacggtt cggcaacaaa cttgtaggta cctatcttat tgttctcgct catcatgatt
      841 cctagtgttt actttgacga tattttgctt cacggtccgc cagatattca ttgacacgct
      901 caaagcagct ggtcgtaatg gctacgcgac ccgaacggac gaactgaagt acgcaatcca
      961 actggcgcaa ctcctcataa agattggtga tttcctcact catgccattc ttctcaacaa
     1021 tggcaaatac agcattcacc tccacaatac gggcattgta cttacggatt actttagaca
     1081 cctccggttt ttcttccagc gtaggagtcg ttattttata gagggcaatc tcgtgctgat
     1141 agatttcatc atccgtgaaa taatgggctt gcagcacatc tattttcttg gtaatctgct
     1201 tggtcacctt ttcaatggta tccttgtccg tccaagcggt aatggtatat ttatgtaccc
     1261 ccttgatgga ggaggccgat acattcaaac tctcgatgtt tatctgccgg cgggtaaaca
     1321 cagccgtcac ctgattcagc aaaccggcaa agttttccga atgaacaatg attgtatata
     1381 gttttttatc catagataga gtaaattctt taatttcgca tgacttcagc attccaacaa
     1441 catctgattg accgaaccgc ccggaggtgt catcggcatt acatttcctt cttcctccac
     1501 acaagcttcg agcaggaacg gtccgtcagt cgctatcatc tcgtcaatcg cttttgccag
     1561 ctcctcgcgg gtcattaccc tgcgtgcagg aatatcatat gccgaagcaa tcttcatata
     1621 atccggattc atcatcggag taaacgaata acgacgattg aagaacatcg cctgccattg
     1681 acgaacattg cccaggaagt tattgttcaa cagaatcatc ttcaccggag ctttttgctc
     1741 catgatggta cccagttcct gcaggttcat ctgcaagccg ccgtctccca tgaatacgca
     1801 taccgtgcgg tccggacgtc caaaagtggc accgatagct gccggaaggc cgaagcccat
     1861 agtacccagg ccaccggaag taacaatgct acgttccttg ctgtatttga aataacgggc
     1921 ggacatcatc tgattctggc cgacatcagt caccaatatc gcctcgttat gggtagcctc
     1981 actcacagca cgcaccacct cacccatgct tagcgctttt cctgccggat gtaattccgg
     2041 acggattacc ttttcctctt ccacttcctc gtattgccgg aaactgtcaa tccattcctg
     2101 atggttggcg ggttccagca attgggtaac ggcagccagt gtctctttgc aatctcccag
     2161 gacagcaaca tcggtcttta cattcttatc tatttcggca gggtcaatat caaagtggat
     2221 aatcttcgcc tgcttggcat atgtttccaa tttacccgtc acacggtcat caaagcgcat
     2281 gcctacggcg ataaggacat cacatttatt ggtattgata ttgggcccca ggttaccgtg
     2341 cataccaagc attcctttgt tcaacggatg gttcgtaggt aatgcggaaa gtcccaataa
     2401 agtgcatccg gcaggcattc cggctttctc aatgaaagca cgaagctctt gctgggcttc
     2461 tcccagctcc acgccttgtc ctaccagcac caaaggccgt tccgcaccat ttattaattc
     2521 agcagccttc cgtatggcct ccggctccat ttcgggaacg ggaagatagc tacggacata
     2581 gtccacctta gtaggcgcat attctgtttt ctccacttgg gcgtttttag caaaatccag
     2641 cacgaccggt cccggacgtc cgctctttgc cacatagaaa gcacgtgcca ctgcccaggc
     2701 cacatcttct gcacgacgaa tctggtaact ccatttcgtg ataggctgag taatgcctac
     2761 caagtccact tcctgaaatg catccgtacc caagaagttc gtccctacct ggccggcaat
     2821 gacaacgata ggcgtactgt caatcatggc atctgcaatg cccgtgatag tattggtagc
     2881 acccggtcca ctggtaacca gacaaacgcc aacctcgcct gatacacgtg caaagccttg
     2941 tgccgcatgg gttgctcctt gttcatggcg aaccaagatg tggttcaatt ccttccggtg
     3001 gtcgtataag gcatcgaata ccggcatgat gctccctccc ggataaccga aaatggtctt
     3061 tactccctga tgctccagag agcgcatcaa tgcttctgcg cctgttatta gagcctcacc
     3121 ccgaccctct ccttgggaga gggaggaaaa gttactcttt ttattattat cagccatact
     3181 ttatctattc attatattta aaagctcaat agtagcttga aaaatttgtt tcattctttc
     3241 ctcccctcgc tttcggaaag gggggctttt aatcaatcag cctcacagcc cctttgtcag
     3301 cggaactcac catactggca tatgctttca atgctttgga gacttcacgg ttgcgggtta
     3361 ccggagtcat agggcgtgct gcaagctctt catccgtcaa cttcacattg atagaacggt
     3421 tcggtatatc aatttcgata atgtccccat ccttaatctt gccgatatta ccaccggcag
     3481 ccgcttcggg agaaacatgt ccgatactta gtccggaagt accaccactg aaacgcccgt
     3541 cggtaatcaa tgcacactcc ttacccagat ggcgggattt gatataagaa gtaggataaa
     3601 gcatctcttg catacccggt ccacctttcg gcccttcgtg agtgatgacg acgacgtctc
     3661 cactgaccac ctttccagcc agaataccgt cacaagccgc atcttgtgag tcgaagactt
     3721 tcgccggccc cgtaaatttc cagatactct cgtctacacc ggcagtcttg acaacgcaac
     3781 cgtcctgagc tatatttccc ttcaaaactg ccagaccgcc atccttgctg tatgcatgtt
     3841 ccaaatcacg gatacaaccg gtcgcacggt ccgtgtcgag ttccttataa gacgcatttt
     3901 gtgaaccaag taccagattg aactttccgg ctgccgcact ggagtatttc ttgattgcct
     3961 ctttacatac attagagctg gtaatactat accggtcgat tgcctctgcc aacgtcattc
     4021 catccacacg gcggacattc gtatcgacca atccgccctt ggcaagctca tccatgatgg
     4081 caatgatgcc accggcacgg ttaacgtctt gtacatgata cttttgggta ttgggagcca
     4141 ccttgcataa gcagggggtc ttgcgggaga gcatgtcaat gtcgtccatc ttaaaatccg
     4201 ctccggcttc gtgagccaca gccaacaaat gaagtaccgt attagtggaa ccgcccatcg
     4261 caatatccag cgtcatggca ttcaaaaatg cctcgcgggt agcaatactt cgcgggagta
     4321 cgctctcatc cccttcttca taatatctaa aggcattctc tacaatcaac ttggctgcat
     4381 cctcaaatag tttcttgcga ttttcgtgag tggctacaat cgtgccgtta ccgggcagtg
     4441 ccaatccaat cgcttcattc aggcaattca tggaattagc ggtaaacatg cctgagcagc
     4501 atccgcaagt ggggcaggca tgttgctcaa tctgtgccac ctctttatcg cccacacttt
     4561 catcagcaga tttaatcatg gcatcaatca aatccaaatg ctgtccgttc cattccccgg
     4621 cttccatcgg accgcctgaa acaaacacag tcggtatatt cagtctcata gccgccatca
     4681 gcatccccgg agtaatcttg tcacagttac tgatgcaaac catagcatcc gccttatggg
     4741 catttaccat atactccaca ctatcggcaa tgatatctct tgaaggcagg gaataaagca
     4801 taccgtcgtg tcccatagcg ataccgtcgt caatggcaat cgtattgaac tccgcagcaa
     4861 aacaccccag tttttcaatc tcttccttta caaactggcc tatttcgtgc agatgtacat
     4921 gcccggggac gaattgtgta aatgaattga ctatagcgat aatgggctta cccatctgtt
     4981 ccttcttcat accattcgcc gtccacaatg cacgggctcc cgccatgcgg cgaccttgtg
     5041 tgctgaacga gctgcgtaac tgatgcttca ttttcaaatc tccttttaat gaaaaagcct
     5101 ctcccactat agtgagaaag gcttaataaa ttatcttcta acgtacgaat acatacataa
     5161 cctttctcac gctcttgatg ccatcaccac gacgcgaata atatgcagga ctgccaggtt
     5221 aatagatgta tgtaaattca taacttaatt cttctttttt gtttcaaacg tgctgcaaag
     5281 gtaagggctt ttttataatc tccaaacaaa ttgaagaaaa aaataagata aatatgaata
     5341 atcgtaagaa aatatcgccc taaaatccta ttttatcact taacagttct aaatagaacc
     5401 attcagacag ccaatgtaaa tgtattgcca atcattgaaa ccatttaata atctgaaaat
     5461 taccaaaggc tctctacatc ccgaaacaaa taattcgtat ctttgtctct tcaaatactc
     5521 aaaaaaaagt atttactaat taaataaaga tagaaaatta atggaaacag tagaaaacaa
     5581 gtacatcacc gtagcatata agctgtactc aatcgaaaac ggagaaaaag atttcgaaga
     5641 agaagcaccc gtagagcatc cttttcagtt tatctcaggt ctgggaatga cactcgaacc
     5701 ctttgaagcc cagataaaag acttgcagat aggcgataaa ttcgacttta ccattccggc
     5761 atcagaagct tatggtgaat atgacgacga ccatgttatt gacctcccca aagaaatctt
     5821 catgatagaa ggagaattcg acagcgaccg tgtagtggaa ggcgccgtca tccccttgat
     5881 gacttctgaa ggtcaacgca tcaatggaag tgtagtagaa gtaaaggaag acgtagttgt
     5941 aatggacatg aatcatccac tcgcaggttg tgatttgaac tttaccggag aagtggtgga
     6001 aagccgtccg gctacgaacg aagagcttgc tgaagttgcc cgtatgatgg gtggcggttg
     6061 cggcagctgc ggttgtggtg actgtggcga cggatgcggc gaccatgaat gtggaggcgg
     6121 atgctgccac taaagaatta aaaattaaag aattaaaaat taaagaat
//
