LOCUS       c00172_gnlPro..        14236 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GILPEFAG_172.
ACCESSION   c00172_gnlPro..
VERSION     c00172_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 12:09:34
            Original ID  :: gnl|Prokka|GILPEFAG_172
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14236
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..609
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg172_1"
                     /sec_met_domain="HBT (E-value: 6e-19, bitscore: 58.3,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="GMKREEVIAVGDGVCDVTMIQLAGLGIAMGHSQDSVKACADYVTA
                     SNEEDGVAVAVEKAIISEVRVAEIPLDQLNAQARHALMGNLGIQYTYADEDRVEATMPV
                     DHRTRQPFGILHGGATLALAETVAGLGSMILCQPDEIVVGMQVSGNHISSAHEGDTVRA
                     VGTVVHKGRSSHVWNVDVFTSTNKLVSSIRVVNSVMKKR"
     protocluster    1..14236
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:4236]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..4236
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14236
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14236
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             606..1721
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg172_2"
                     /sec_met_domain="Chorismate_bind (E-value: 8.6e-58,
                     bitscore: 185.8, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDEEISNLTTIDAFIQRKQPFAVYRIPGEKVPRLLTQAEGAVRL
                     IYDLKELNGQRGFVIAPFQVSETCPVVLIQPDQWGQPLPIDNDTAEEREVALRMQRQES
                     FLTSSTEEYASCFHTFINALRERTFDKLVLSRHLTVDKVADFSPLSIFRAACKRYIHSY
                     IYLCYTPQTGIWLGSTPEIILSGEKDEWHTVALAGTQPLQDGRLPQVWDEKNRKEQDYV
                     ASYIRRQLLSLDIHSTENGPYPAYAGALSHLKTDFRFSLKDNKGLGDLLKVLHPTPAVC
                     GLPKEEAYQFILQNEGYDRRYYSGFIGWLDPEGRTDIYVNLRCMHIEDKQLTLYAGGGL
                     LASSELNDEWLETEKKLQTIKRLIAVPPLKS"
     CDS             1741..3408
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg172_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.6e-08, bitscore:
                     22.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTDKKNILQLVALLEAHGITKVVLCPGSRNTPIVHTLSNHPNFT
                     CYAVTDERSAGYFAIGLALNGGKPAAVCCTSGTALLNLHPAVAEAFYQNVPLVVISADR
                     PAAWIGQMDGQTVPQPGVFQTLVKKSVNLPEIHTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINVPISEPLFQFTVDTLPEVRVITRYQGLNVYDRDYNDLVDRMNKYQKRMIIIGQMN
                     LIYLFEKRYIKLLYKHFAWLTEHIGNQTVPGIPVKNFDAALYAMPEEKVGQMVPELLIT
                     YGGHVVSKRLKKFLRQHPPKEHWHVSPDGEVIDLYGSLTTVIEMDPFEFLEKIASLLDN
                     RTPDYPRVWENYCKIIPEPDFAYSEMLAVGTLLKALPESCALHLANSSVVRYAQLYSIP
                     PTIEVCCNRGTSGIEGSLSTAVGYAAASDKLNFIAIGDLSFFYDMNALWNINVRSNLRI
                     LLLNNGGGEIFHTLPGLDMSGTSHKFIAAVHKTSAKGWAEERGFLYLQAQNDEELTEAM
                     KTFTQPETMEQPVLLEVFTNKNKDARMLKNYYHQLKQK"
     CDS             3412..4236
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg172_4"
                     /sec_met_domain="ECH_1 (E-value: 1.4e-82, bitscore: 266.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTQREWTTIREYDDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKQYPKFP"
     CDS             4298..5323
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg172_5"
                     /sec_met_domain="MR_MLE_C (E-value: 5.2e-30, bitscore:
                     94.6, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDCKIDIIPRLLHFKQPAGTSRGIYTTRKVWYLHFTSPDFPGRVG
                     IGECAPLPALSCDDLPDYEDILKRICRQVEKEQGMWDKDVLCQYPSILFGLETAIWHFF
                     AGSWALSDTAFSRGEVGIPINGLIWMGDFDHMLSQIEKKMEAGFRCVKLKIGAIDFEKE
                     LALLRHIRTHFSSKEIELRVDANGAFSPGDAMEKLKRLSEFDLHSIEQPIRAGQWEEMA
                     RLTSESPLPIALDEELIGCNTLEEKKKLLATIRPQYIIIKPSLHGGICGGDEWIMEAEK
                     QHIGWWITSALESNIGLNAIAHWCATFNNPLPQGLGTGMLFTDNIEVPLEIRKDCLWFC
                     K"
     CDS             5355..6470
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 56.3; E-value:
                     7.3e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg172_6"
                     /sec_met_domain="AMP-binding (E-value: 1.8e-18, bitscore:
                     56.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFDRQQQRLLLEGKEYTFEDISQLIAGGAEAHSSAYWDLYLFLN
                     EWFNDSPVITVHTSGSTGIPKELMVRKDQMMQSARLTCEFLNLKKGESALLCMNLRYIG
                     AMMVVVRSLVAGLNLIVRPASGHPLADIKESLRFVAMVPLQVYNTMQVPEEKERLKQTD
                     ILIIGGGAVDEALETEINHLPTAVYSTYGMTETLSHIALRRLNGASASEHYYPFPSVKL
                     SLSAENTLIIDAPLVCDETLQTNDIARIYPDGSFMILGRKDNVINSGGIKIQAEEMEKL
                     LRPFIPVSFVITSVPDQRLGQAVTLLLADQPDTEEIGNKLHEILEPYYRPKHILTIESI
                     PQTENGKINRAECRILAKQMLMTFYPHTLTP"
     CDS             complement(6843..7406)
                     /locus_tag="ctg172_7"
                     /transl_table=11
                     /translation="MKISFSKQTKERAFKQLYEEYYAPFCLYAKRFVDDKETREDIVSD
                     VFTSLWDKLDTDSFDLQSNTALAYIKMCVKNSCLNFLKHQEYEWSYAENIQKKAPVYET
                     EPDSIYTLDELYRMLYETLNKLPENYRTVFIKSFFEGKTHTEIAEEMNLSVKSINRYKQ
                     KTMELLRNELKEYMPLLLLLFLRA"
     CDS             7580..9571
                     /locus_tag="ctg172_8"
                     /transl_table=11
                     /translation="MKNKFFLLAITFCLPIHSQGVSKSFIPMAEIPAGSFYMGSDGLGE
                     DFDEAPIHQVIISRPFRMGITEITNAQYESFRPEHRALRGKNGVSLEDDEAVVNVSYSD
                     AVAFCEWLSRKEGKNYRLPTEAEWEYACRAGTYTLFSTGDGLPAVYHRNQKVVRDFDPV
                     SLKVAQTPPNTFGLYDMHGNVEEWCLDWYAPYSAEKQKDPAGPLTGEFRVTRGGSHHTP
                     EKYLRSANRLAMLPEDKHSQTGFRIVEADTRLNVSGTSAPVPFNQKSVENTSIKWKKVS
                     AITPMFLPPIPFVVRPVCDSNTPFYLHNHQPAVTWCDNGDLLAIWFSANEENGRGMVVL
                     GSRLRAGHTDWDVASLFFKVPDRNMTGSALLNDGKGKLYHINGVEASGDWQNLAMVLRT
                     STDNGASWSTPKLIAPEHTKRHQVIAGTIRTREGWLVQACDAGPGSHDGAAVQISKDGG
                     KTWCDPWDGAPLPDFKEGGTGSTIAGIHAGIVQLGNGSLMAMGRGNSIRNKEGKLRMPM
                     SISDDMGKTWKYVASELPPIDGGQRLVLMRLNEGPLLLVSFTDHPQRTPLEERGLEFKD
                     KNGNVKKGYGMYAALSYDEGKTWPVRKLLTDGEYRFLNGGAWTGYFEMDENHAEPRGYL
                     AGTQTPDNVVHILSSRLHYRFNLAWLEK"
     CDS             9675..10586
                     /locus_tag="ctg172_9"
                     /transl_table=11
                     /translation="MSPESLLRKAQALGDDIKEMESIDVLGAYYQAQTKIKTNRRKNMY
                     NQLMRYAAFLTIPLFLSSLVLGYLYFSGTETDEKYAEVVTATGSVIRYELPDHSVVWLN
                     AGSTLRYPTTFKKDNRLVELKGEAYFEVQADKDRPFYVNTPNGLSVYVYGTKFNVAAYE
                     DDNYIETVLEKGKVNVITPDQETIVLAPGEQLLYDKQSQKSKKNKVDVYGKIAWKDGKL
                     IFRNASLEEILKRLERHFNVEIQFNNRSGKEYKYRATFRTETLSQILDYLARSADLKWK
                     IEEPQQQADDTLSKTKIRVDLY"
     CDS             complement(10567..10737)
                     /locus_tag="ctg172_10"
                     /transl_table=11
                     /translation="MNYGLIPASVCETLYRESGKFGGRQLLVAAFFLSFILLCYSMGLY
                     FKGYYSNINLL"
     CDS             10838..14131
                     /locus_tag="ctg172_11"
                     /transl_table=11
                     /translation="MRISLALLFAVVLQLSAEDGYAQRTRVAISMNNVSVEQVLNKIEE
                     TSDYVFLYNDKTIQKNRIVSVRNNSGKILDILDEVFKGTNITYTVVDKQIILSTNKLNV
                     TEQDPTIQVKGTVKDTKGEPLIGVNVKVKGTTTGAITDFDGNFQIQAKKGAVLEISYIG
                     YASQEVKVTDNKSLSIVMTEDAKVLNEVVVTALGIKRETKSLTYNVQQIGGDEVAKAKD
                     MNVMSSLAGKVAGVNINASSSGIGGGARVVMRGTKSISGNNNALYVVDGVPLANISGEQ
                     PDDQYTGAGQSGDGLANFNADDIESISVLSGSAAAALYGSAAANGVVLITTKKGAVDKT
                     RLTYSNNSTFYSPFRLPEFQNTYGSETGEWYSWASKLSSPTDYEVKDFFQTGYNVANTV
                     SLTTGTQKNQTYVSVGAVNARGIIQNNDLDRYNFSVRNTTSMLNDKLTMDLSFMYSNVK
                     EQNMLSQGEYANPLVPVYLFPRGDDFSKYQYYERYDVDRNIKTQFWPLKENGLSMQNPY
                     WITNRNMYTNKKDRFLASGSLKYTITDWLNVSGRVKLDKETINSEKKMYASTLNVIAEN
                     SDKGAYVQSNKNTSQIYADAMLNINKYFYHDTWNLTASLGASLLDLDYKELNFGGGLLT
                     IPNLFTSNNANVSGKLTYKNTNYHDRTNSLFGTFSLGYKGMVYVDGSLRNDWISALAGT
                     NHSSILYPSIGASAILTNMFTMKSNILSYAKVRLSYSEVGNAPERFRAITTYAVLGGLN
                     TTSYFPIKDLKPERTHSWEGGFNLGLFDNKLTLDVTAYKTYTENQLFSPEISTTTGYSK
                     LYVNAGKVTNKGIELALGFKQNIGPVDWKTTLLWSLNRNRIDQLLPEYTNEELGVTVHL
                     DEMDVYSLGGAKQRLTVGGSMGDVYVNTMRTDEHGHIWMNSMTGTLETDKNNYVYAGNT
                     NPKYTLSWRNEFNWKGISLGFMLNARVGGIGVSATQAVMDYYGVSKTSAEARDNGGVKV
                     NGQMIDAQTWYQTIGANGTGYVGSMYVYSMTNVRLGELTLGYDIPINKWCKWISGLNVS
                     FVGRNLWMLYCKAPFDPESTASTGTYNQGMDYFMQPSLRSMGFSAKISF"
ORIGIN
        1 ggtatgaagc gtgaggaagt gattgctgtg ggcgacggtg tgtgtgacgt aacaatgatt
       61 caattggcgg ggctgggcat agctatggga cattcacaag actcggtgaa agcctgtgcc
      121 gattatgtga ctgcttcgaa tgaggaagac ggagtggccg ttgcagtgga gaaggctatc
      181 atatccgaag tgcgtgtagc cgaaattccc cttgaccaac tgaatgcgca ggcacgccac
      241 gcattgatgg gaaacttggg aattcaatat acctatgccg acgaagaccg tgtggaagca
      301 acaatgccgg tagaccatcg tacccgtcag ccttttggca ttttgcatgg cggggctact
      361 cttgcattgg cggaaacagt tgccggactc ggttcaatga ttctttgcca gccggacgag
      421 attgtagtag gaatgcaggt cagtggaaac cacatatctt ctgcacatga aggagataca
      481 gtgcgtgcag taggaacagt tgtacataag ggacgttcct cccatgtatg gaatgtagac
      541 gtgtttactt caacaaacaa actagtgtct tccatacggg tagtcaacag tgtgatgaaa
      601 aagagatgac cgacgaagaa ataagtaatt tgacaactat tgatgcattt attcagcgga
      661 agcagccgtt tgctgtttac cgtattcccg gggagaaagt tccccgtctg ttgacacagg
      721 cggaaggagc ggtacgtctg atatacgacc tgaaagaact gaatggacag agaggatttg
      781 tcatcgctcc gtttcaggtg agtgagacgt gtcctgtcgt attgattcaa cccgatcagt
      841 gggggcaacc tttgccgatt gacaatgata cggcagaaga acgggaagtc gctttgcgga
      901 tgcaaagaca agaatcgttc ctgacttctt ctacggagga atatgcctcc tgctttcata
      961 cctttataaa tgcattgcgt gagaggacgt ttgataaact agtgctttcc cgtcatctta
     1021 cagttgataa agtagcggat ttttctcctt tgtccatctt tcgggcggct tgtaaacgtt
     1081 atattcattc gtatatatat ttatgttata ctccgcagac aggcatctgg ctgggaagta
     1141 ctcccgaaat tattttatca ggtgagaaag acgaatggca tacggttgcg ctggccggaa
     1201 cacagccttt gcaagatggc agactgccgc aagtatggga tgaaaagaac cggaaagaac
     1261 aagattatgt tgcttcttat atccgtcggc agcttctttc actggatatt cattctacgg
     1321 aaaacgggcc atatcctgct tatgccggtg ctttgtcaca tttaaaaact gatttccgtt
     1381 tttctttgaa agataataaa ggtttgggag accttctgaa agttttgcat ccgacacctg
     1441 ccgtatgcgg cttgccgaag gaagaagcct atcagtttat tttgcagaac gaaggttacg
     1501 accgccgcta ttactccggc tttatcggat ggctcgatcc ggaaggacga acagacatct
     1561 atgtaaactt acgctgtatg catatcgaag ataaacaact tactctttat gccggcggtg
     1621 gattattggc ctcttcggaa ttgaatgacg aatggctgga aacggagaag aagttgcaaa
     1681 ccatcaaacg gctgattgca gtgcctcctt taaaatcata aactactaat aattatcatc
     1741 atgtatacag acaagaagaa catactccag ttggttgcgt tgctcgaggc gcatgggatt
     1801 actaaggttg tgttgtgtcc gggtagtcgt aatacgccca tagtacatac tttgtctaat
     1861 catccgaact tcacctgtta tgcagtgacg gatgaacgga gtgccggtta ttttgccatt
     1921 ggtcttgcgt tgaatggtgg taagcctgct gctgtgtgct gcacttccgg tactgcatta
     1981 ttaaatcttc atccggctgt agccgaagca ttttatcaga atgttccttt agttgtcatt
     2041 tcagcagacc gtcccgctgc ctggatcgga cagatggatg gacaaacagt gccgcaacca
     2101 ggtgtgtttc aaacgctggt aaagaagtcg gtcaatcttc cggagattca tacggaagaa
     2161 gatgaatggt attgcaatcg cctggtgaat gaagctttgc tggagacgaa tcatcatgga
     2221 aaagggccgg tgcatatcaa tgttcctatt tccgaaccac tgtttcagtt cactgtagat
     2281 acgctcccgg aagtgcgtgt gataacccgt tatcagggat tgaacgtcta tgaccgtgat
     2341 tataatgatc tggtcgaccg gatgaataaa tatcagaagc gcatgattat catcggtcag
     2401 atgaatctta tctatctgtt tgaaaaaaga tatatcaagt tattatataa acattttgcc
     2461 tggttgacgg aacatatcgg caatcagaca gttcccggta ttccggtaaa gaatttcgat
     2521 gcggcacttt atgccatgcc cgaagagaag gtcggtcaga tggttcccga attgctgatt
     2581 acttatggag gacatgtcgt ttccaaacga ttgaagaagt ttcttcgtca gcatccgcct
     2641 aaagaacatt ggcacgtatc gccggacggt gaggtgatcg atttgtacgg ctcattaact
     2701 acggtgatcg aaatggaccc gttcgagttt ctggagaaga tagccagcct gctggataac
     2761 cggactcctg actatccccg tgtatgggag aattattgta agattattcc cgaaccggat
     2821 tttgcctatt cggagatgtt ggctgtcggt acattattga aagctttgcc ggagtcctgt
     2881 gcattgcatc tggcaaacag ttcggtagtt cgttatgcac aactatattc gattcctcct
     2941 acaattgaag tttgttgcaa tcggggaaca agtggtattg aaggatcgtt gtctaccgct
     3001 gtcggttatg cggcagcttc cgacaaactg aatttcatag ctatcggaga tctaagtttc
     3061 ttctatgata tgaatgcgtt gtggaatatc aacgtccgtt ccaacctgcg tatcctttta
     3121 ttaaataacg gaggaggaga gattttccat actttaccgg gattggatat gtcgggcacc
     3181 tcacataaat ttattgcagc agttcataaa acgtcagcca aaggctgggc ggaggaacgt
     3241 ggtttccttt atctgcaggc acaaaatgat gaagagctga ctgaagcaat gaaaactttc
     3301 acccagccgg aaactatgga acaacctgtg ctcctggaag tgtttaccaa caaaaacaag
     3361 gatgcacgta tgttgaagaa ttattatcat caattaaaac aaaaataaat tatgccaaca
     3421 caaagagagt ggacaaccat cagagaatac gacgatattc tttttgatta ttataatgga
     3481 attgcccgta tcacaatcaa ccgtgaacgt tatcggaatg catttacccc gactactact
     3541 gccgaaatga gtgatgcatt gcgcatttgc cgtgaagaag cggatattga tgtgattgta
     3601 attaccggag ccggtgataa ggcattctgt tcgggaggcg accagaatgt gaaaggacgt
     3661 ggcggatata tcgggaaaga cggtgtgcct cgtttgagcg tattggatgt acaaaagcaa
     3721 attcgtagta ttccgaaacc tgtgattgct gccgtgaacg gctttgccat tggtggcgga
     3781 catgtgctcc atgtagtatg tgatttatcc attgcttcgg aaaatgccat tttcggtcag
     3841 acaggtcctc gcgtgggtag ctttgatgcc ggattcggtg catcttatct ggcacgcgtg
     3901 gtagggcaga agaaagcacg tgaaatttgg ttcctttgcc ggaagtataa tgcacaggaa
     3961 gcattggata tgggattggt gaataaggta gtacctttgg aacaactgga agatgaatac
     4021 gtgcagtggg cggaagaaat gatgttgctt agtccgttgg ctttgcgcat gattaaagcg
     4081 ggattgaatg ccgaactgga tggtcaggca ggtattcagg agttggcagg tgacgcaaca
     4141 ttactttatt acctgacgga tgaagcacag gaaggcaaga atgcgttctt ggagaaacgt
     4201 aaaccgaact tcaaacaata tccgaaattc ccttaaaaat gataggctaa tgaaagactg
     4261 attgtgcagt aattaacaga ttgaaaagat attcattatg gattgtaaga tagatattat
     4321 tccccggttg cttcatttca agcaacccgc gggaacttcc cggggaatat atactacccg
     4381 aaaagtctgg tatcttcact ttacttctcc tgactttccg ggtagagtgg gaattggaga
     4441 gtgcgcgcct ttgcccgctt taagttgtga tgatctccct gattatgaag atatattaaa
     4501 aagaatttgt cggcaagtag agaaagaaca aggaatgtgg gataaggatg ttttatgcca
     4561 atatccttcc atcttatttg gtttggaaac ggctatctgg catttctttg cagggagttg
     4621 ggctttgtcc gatacggctt tttcacgtgg agaggtaggg attccaatca acggcctgat
     4681 ctggatggga gattttgatc acatgttatc ccagatcgag aaaaagatgg aagccggatt
     4741 ccgttgtgtc aaactaaaga ttggtgctat cgattttgaa aaagaattgg cgttgttacg
     4801 tcatattcgt acccatttct cttctaaaga aatagagttg cgtgtagatg caaacggtgc
     4861 tttctctccg ggtgatgcaa tggaaaaact gaaacgtctg tcagaatttg atttacattc
     4921 tatcgaacag ccgatccgtg ccggacaatg ggaggaaatg gcccggctca cttctgaatc
     4981 tccgttgccg attgcattgg atgaagagct gataggatgc aacacgctgg aagaaaaaaa
     5041 gaaactgctg gcaaccatcc gtccgcaata tatcatcatt aaaccatctc tccacggagg
     5101 aatatgcgga ggggatgaat ggattatgga agcggaaaag caacatatcg gctggtggat
     5161 cacttccgct ttggagtcca acattggttt gaacgctatc gcccattggt gtgcaacatt
     5221 caataatccg ttgccacaag gattgggaac gggtatgctc tttactgaca atatagaagt
     5281 gcctcttgaa atcagaaaag attgcctgtg gttttgtaaa tgatagtatt tagtggtatt
     5341 taaaggatat tctgatgata tttgatcgac aacaacagcg cttgctactg gaaggaaaag
     5401 aatacacttt tgaagatata agccaactga tagcaggagg agcagaagct cattcttctg
     5461 cttattggga tttatatctt ttcctgaacg aatggtttaa tgattctcct gttattacag
     5521 ttcatacatc gggctccacg ggtataccta aagaactgat ggtacgcaag gatcaaatga
     5581 tgcaaagtgc acgtctgact tgtgaatttc tgaatttgaa gaaaggtgag tcggcattat
     5641 tatgtatgaa tcttcgttat atcggtgcaa tgatggtggt cgtacgttca ttggttgcag
     5701 gcttgaacct gattgttcgt cctgcttccg gtcatccgtt ggcggatata aaagaatctt
     5761 tgagatttgt ggcaatggtc ccattgcaag tttataacac gatgcaggtt cccgaagaaa
     5821 aagagcgatt aaaacaaacg gatattctga ttataggagg cggagccgtt gatgaggctc
     5881 tggaaacgga gataaaccat cttccgactg ccgtttactc cacttatggc atgactgaaa
     5941 ctttgtcgca tattgccctt cgtcgtctga acggagcatc ggcttcagaa cattattatc
     6001 catttccttc agtaaaattg tctttatccg cagagaatac attaatcatt gatgcccctt
     6061 tggtatgtga cgaaacattg caaaccaatg acattgcacg tatctatccc gatggaagtt
     6121 ttatgattct aggccggaaa gacaatgtga ttaacagtgg aggaattaag attcaagcag
     6181 aggagatgga gaagttgctc cgcccgttta ttcctgtgtc ctttgtcatt acttcagttc
     6241 cggatcagcg cttagggcag gctgtcactt tattattggc agatcagccc gacacagaag
     6301 aaatcggaaa taaactacat gaaatactgg aaccttatta tcgtcccaag catatattga
     6361 caatagaatc cattccgcaa acagagaacg gaaaaataaa ccgggcagag tgtcgcatct
     6421 tagccaaaca aatgttgatg acattttacc ctcacaccct cacaccttga ttcaatccct
     6481 ttattcatcg gtgtttcaag tgtgagggta gaggtgaggc cagggtgagg gtaacttttt
     6541 accctcaccc tggctcgtct tgttcccagc taatttatac tatatttccc tatatatcat
     6601 acattgatac ttaggtattc ttttgttaag ctctaatgtt ttacaagggc tcacccatgt
     6661 aaacaaatct gtttacaacc gtaaacggat ttgttcacaa ctgatagctt atctgtccac
     6721 acaagtaagc ccctgctaac tattaagcag agtgatataa acaacaggac taatacatat
     6781 atagagtacg actgtttttc aaaagaaagg catataccag gaagagaaca tgaggatgta
     6841 gattatgcac gaagaaataa caagagtaat agtggcatat actcctttaa ttcattacgt
     6901 aaaagttcca tcgttttttg tttatatcga ttgatagact tcacgctaag attcatctct
     6961 tctgcaatct ctgtatgagt tttgccttca aagaaacttt taataaagac cgttcgatag
     7021 ttttcgggaa gtttgtttaa tgtctcatac aacattctgt atagctcatc aagagtatat
     7081 atactatccg gttctgtttc atagacagga gctttcttct gtatattttc cgcatagctc
     7141 cattcatatt cctgatgttt caggaaattc aggcagctat tttttacgca cattttgatg
     7201 taagctaatg cggtgttcga ttgaagatca aaagaatcag tatccagttt atcccataat
     7261 gaggtgaata catccgaaac gatgtcttca cgtgtttctt tatcatcaac aaaccttttt
     7321 gcatacaaac aaaatggggc ataatactcc tcataaagtt gtttgaaagc ccgttcctta
     7381 gtctgtttgg aaaaagatat tttcattatt tagaggttct gtagtttttc attttgctgc
     7441 aaatatataa taagataatt atcaaagcct aattttcgat tctttttttt gctttcaaca
     7501 ctaatgaata gaaaataatc agatgaggct gtccttttgt atataggttg attgtattat
     7561 atataaacgg gattaaaata tgaaaaacaa gtttttttta ttggctataa ccttttgttt
     7621 gccaatacat tctcaaggag tttccaagtc ttttattccg atggctgaaa tacctgccgg
     7681 aagtttttat atgggaagtg acggattagg cgaagatttt gatgaggctc ctatccatca
     7741 ggtaataatc tctcgcccgt ttcgtatggg aatcactgaa ataacgaatg cgcaatatga
     7801 atcattccgt ccggaacatc gggcattacg aggaaaaaac ggtgtttcgc tggaagatga
     7861 tgaagcagtc gtcaatgtga gttattccga tgctgttgcc ttttgtgaat ggcttagccg
     7921 gaaagaaggc aaaaactatc gtttgccaac agaagcggaa tgggaatatg cttgtcgggc
     7981 aggcacatac acactatttt ctacaggaga cgggttacct gcagtttatc atcggaatca
     8041 aaaagtggtt cgtgactttg atccggtatc tttaaaagta gcccagactc ctcctaatac
     8101 attcgggctt tatgatatgc atggaaatgt ggaagaatgg tgcttggatt ggtatgctcc
     8161 ttattccgca gaaaagcaga aagacccggc aggaccgttg accggagagt ttcgggtcac
     8221 tcgaggaggg agtcatcaca ccccggagaa atacttgcga agtgccaatc gactggctat
     8281 gctcccggaa gataaacatt cccaaaccgg atttagaatt gtggaagcag atactcgttt
     8341 gaatgtatcg ggaacatctg cccctgtccc gttcaatcag aaatctgtag aaaatacatc
     8401 tataaaatgg aaaaaagtat ctgctatcac accgatgttt ttgcctccga taccatttgt
     8461 ggtacgtccg gtatgtgatt cgaatacccc attttatctg cataatcatc agcctgcagt
     8521 tacgtggtgt gataatggag atttgctggc aatatggttt tctgcaaatg aagagaatgg
     8581 gagagggatg gtagtactcg gttcccgctt gcgtgccggg cacactgatt gggatgtggc
     8641 ttctttattc tttaaagttc cggatcggaa tatgacagga agcgctttgc tcaatgacgg
     8701 gaaaggaaaa ttgtatcata tcaatggagt ggaagcatcg ggagactggc agaatctcgc
     8761 aatggtacta cgtaccagca cagataacgg tgcttcatgg agcactccta aactgatagc
     8821 tcccgaacat accaaacgtc atcaggtaat agctggtacg attcgcacac gtgagggatg
     8881 gctggttcaa gcctgtgatg cgggtcccgg cagtcatgac ggggcagctg ttcaaatcag
     8941 taaagatgga ggaaaaacat ggtgcgatcc ttgggatggc gctcctttgc cggatttcaa
     9001 agaaggagga acgggaagta caatcgcagg tatccatgcg ggaattgtac aattagggaa
     9061 cggaagtttg atggctatgg ggcgtggtaa tagcatacgg aataaagaag gaaagctccg
     9121 aatgccaatg agcatatcag atgatatggg aaagacctgg aaatatgtag caagcgaact
     9181 ccctcctatt gacggaggtc agcgtcttgt tttaatgaga ctgaatgaag gacctttgct
     9241 attggtttct ttcacagacc atccgcaacg tacgcctttg gaagaacgtg gtctggaatt
     9301 taaggataaa aatggaaatg tgaagaaagg atatggcatg tatgcggctc tttcctacga
     9361 tgagggaaaa acatggccgg taagaaaact actgacggac ggtgaatatc gttttttaaa
     9421 cggtggagca tggacgggat atttcgaaat ggatgaaaat catgctgaac cacgtggcta
     9481 tcttgcagga acacaaactc ctgataatgt ggttcatatc cttagtagcc gattgcatta
     9541 ccgcttcaat ttggcatggc tcgaaaaata aaataaaaaa agtttgtttt tgctgtcctt
     9601 ttccaattac ttcagttgta ttataagtgt aattacaatt aaaagataag attttgaaag
     9661 aaaatatgga aaatatgagt ccggaatcat tgctccgtaa agcacaagca ttgggagatg
     9721 atattaaaga aatggaatcc attgatgtat tgggtgccta ttatcaagca caaaccaaaa
     9781 taaaaactaa tagaagaaag aacatgtata atcaactgat gcgttatgca gcatttctga
     9841 ctataccttt atttctctct tctctggttt tgggatattt atattttagt ggaacagaaa
     9901 ccgacgagaa atatgcagag gtggtaaccg ctaccggttc tgtcatacgt tatgaacttc
     9961 cggatcattc tgtagtatgg ttgaatgcag gtagtacatt gcgttatcct accactttca
    10021 agaaagacaa ccggttggta gaactgaagg gtgaggcata tttcgaagtg caggcagaca
    10081 aagatcgtcc tttctatgta aatactccga atggcttgag cgtatatgtt tatggtacca
    10141 aatttaatgt agctgcttat gaggatgata attatataga aacagtattg gaaaagggta
    10201 aggtaaatgt gataaccccc gatcaggaaa caatcgtatt ggctcctgga gaacagttgc
    10261 tttacgacaa acagagtcaa aagtcgaaaa aaaataaagt ggatgtctat ggaaagatag
    10321 cttggaaaga tggaaaacta attttcagaa atgcttcatt agaagaaatc ctgaagcgtc
    10381 tggaacgaca tttcaatgta gaaattcagt ttaacaatag gtctggaaaa gaatataagt
    10441 accgggctac tttccggact gaaactctgt cgcagatatt ggattatctg gccaggtctg
    10501 ccgatttaaa atggaaaatt gaagaaccgc aacaacaggc agatgataca ttatcaaaga
    10561 ctaaaattag agtagattta tattagagta gtaaccctta aaataaaggc ccatggaata
    10621 acacaagaga ataaaagaaa ggaagaaagc tgctaccaac agctgtcttc ctccgaattt
    10681 tccagattca cggtacaagg tctcgcaaac actagccgga atcaaaccat agttcattta
    10741 gtaataaact ttagttagcc acaaatgtat gaaaaaaaat cattcattta cagcattatg
    10801 tcctaaatat gctttaaatc taaaacttcc tttagttatg aggattagtc tagcactact
    10861 tttcgcagta gtattacaac tttctgccga agatggctat gcccagcgaa cgcgggttgc
    10921 catttcaatg aacaatgtat ctgtagaaca ggtactgaat aaaatagagg agacgtccga
    10981 ctatgttttc ctttataatg ataaaacaat tcagaagaat cgtattgttt ctgtgagaaa
    11041 caattcaggt aagatcctgg atattcttga tgaggtattt aaaggaacca acattactta
    11101 tacagtggtt gataagcaga ttatcttgtc taccaataaa ttgaatgtaa cagagcaaga
    11161 tccgactatt caggtaaaag gtacagtgaa agatacaaaa ggagaacctt tgatcggagt
    11221 gaatgtgaaa gtaaaaggga caactaccgg tgctattaca gatttcgacg gaaactttca
    11281 gattcaagct aaaaagggag cggtattgga gatctcttat attggatatg cttctcaaga
    11341 ggtgaaggtt acagataata aatcgctttc cattgtgatg acggaagatg caaaagtctt
    11401 gaatgaggtt gttgtaacgg ctttgggcat taaacgcgaa accaagtctt tgacatacaa
    11461 tgtgcagcag attggcggcg acgaagtggc aaaggcgaaa gatatgaatg tgatgagcag
    11521 tcttgccggt aaggtggcgg gtgtgaatat caatgcaagt tcatccggta ttggaggcgg
    11581 tgcccgtgtg gtaatgcgtg gtacgaagtc tatatcaggt aataacaacg ctctatatgt
    11641 agtagatgga gttcctttgg ctaatatatc aggtgaacaa cccgacgatc agtatacggg
    11701 tgccggacaa tccggtgacg gattggctaa cttcaacgct gatgatatag aatcaatttc
    11761 agtacttagc ggatcggccg ccgctgcact atacggttcg gctgctgcca atggtgtggt
    11821 acttatcaca acgaagaaag gagctgtaga taaaaccaga ttgacttaca gtaataattc
    11881 aactttctat tcaccattcc gattgccgga attccagaat acgtatggtt cggaaactgg
    11941 agagtggtat agttgggcat ctaaattgtc atctcctacc gattatgaag ttaaagattt
    12001 ttttcagaca ggttacaatg tagcaaacac tgtaagtctg actacaggga cacaaaaaaa
    12061 tcaaacctat gtatccgtag gtgctgtgaa tgcccggggt atcattcaga ataatgactt
    12121 ggacagatat aatttctctg ttcgtaacac gacctctatg ctgaatgata aactgacgat
    12181 ggatttaagt tttatgtatt ctaatgtaaa ggaacagaat atgttgtcgc aaggagagta
    12241 tgccaatcca ttggttcccg tttatttatt tccgcgcggt gatgatttct cgaaatatca
    12301 gtattatgaa cgatatgatg tagaccgtaa cataaaaaca cagttctggc cattgaaaga
    12361 aaatggatta tccatgcaga atccttactg gattacgaac cggaatatgt ataccaacaa
    12421 gaaagaccgt tttctggcaa gcggttcact aaaatatacg ataacagatt ggttgaatgt
    12481 ttccggacgc gtgaaactgg ataaggaaac tatcaactcg gaaaagaaaa tgtatgcttc
    12541 cactttgaat gtgattgctg aaaactcgga taaaggagca tacgtgcaat cgaacaagaa
    12601 taccagtcag atatatgcgg atgccatgtt gaatatcaat aaatatttct atcacgacac
    12661 atggaatctg acagcatctt taggtgccag tttattggat ttggattata aggaacttaa
    12721 ttttggcggc ggattgctga ccattcctaa tctgtttact tctaacaatg cgaacgtttc
    12781 cggtaaatta acctataaaa atacgaacta tcacgaccgt accaattctt tattcggaac
    12841 attctcatta ggatataagg gcatggttta tgtagatggt tcgttacgta atgactggat
    12901 atctgctttg gcaggaacaa accattcttc catattatat ccttctatcg gtgcttcagc
    12961 gattctgact aatatgttta caatgaaatc taacattctt tcttatgcaa aggtccgcct
    13021 ttcatatagt gaggtgggta atgcaccgga aagattcagg gctatcacta cttacgcagt
    13081 gttgggaggg ttgaatacca cttcttattt cccgataaaa gaccttaaac cggagagaac
    13141 tcattcatgg gaaggaggat ttaatttagg tctgtttgat aataaactga cactggacgt
    13201 gacagcttat aagacatata cggagaatca gctcttcagt ccggaaattt ctacaacaac
    13261 cggatattct aaattatatg taaatgcagg taaagtaacg aataaaggta ttgagttagc
    13321 tcttggcttt aaacagaata tagggcctgt agattggaaa acaactttac tatggtcgct
    13381 caacagaaac cgcattgacc aattactccc tgaatataca aatgaagagt tgggagtgac
    13441 agtacatctg gacgaaatgg atgtctattc gttaggcggt gccaaacagc ggctaacagt
    13501 agggggctct atgggagatg tatatgtgaa tacaatgaga actgatgagc atggacatat
    13561 ctggatgaat tcaatgacgg gtacattgga aacagataag aataattatg tctatgctgg
    13621 taataccaat ccgaaatata ctcttagctg gagaaatgaa tttaattgga aaggaatcag
    13681 tctcggattt atgttgaatg cccgtgtagg tggtatcgga gtttctgcca ctcaagctgt
    13741 aatggactat tatggagtgt ctaagacatc ggcagaagcg cgggataatg gtggcgtgaa
    13801 agtaaacggc cagatgattg atgcccagac atggtatcag actatcggag ctaatggtac
    13861 aggttatgta ggttctatgt atgtatatag tatgacgaat gttcgtttgg gagaattgac
    13921 attgggatat gatattccga tcaataaatg gtgtaaatgg atttctggat tgaatgtgtc
    13981 ctttgtagga cgtaatttat ggatgctata ttgtaaggct ccatttgacc cggaatctac
    14041 tgcaagtaca ggtacttata accagggtat ggactatttc atgcaaccga gtttgagatc
    14101 gatgggattt tctgcaaaga tttctttcta attggataac ctttaaaaaa aataatgatg
    14161 aacatacgta agttttttaa agtaaggaac tactacttac tccttggagt aatcatgata
    14221 aatgtaggtt gtacaa
//
