LOCUS       gnlProkkaIEMGGBMM_284  11671 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IEMGGBMM_284.
ACCESSION   gnlProkkaIEMGGBMM_284
VERSION     gnlProkkaIEMGGBMM_284
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 09:33:38
            Original ID  :: gnl|Prokka|IEMGGBMM_284
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11671
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11671
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3557:3911]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3558..3911
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..11671
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11671
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             3..338
                     /locus_tag="ctg284_1"
                     /transl_table=11
                     /translation="MTELKKLVHEIMSERGAVTSNVGTFYTPAPVVAPTPSVPAIIHPV
                     KPNCPDDDDIQDTEEYVEESLSLDEVEKEMIRKALEKHHGKRKSAAKDLNISERTLYRK
                     IKEYGLE"
     CDS             346..846
                     /locus_tag="ctg284_2"
                     /transl_table=11
                     /translation="MRISLLVFTLVVGISCTVSYKFNGGNINYDKVKTISIADFPIKSD
                     YVYAPLGTKFNEDLKDIFLRQTRLKLVNNNADLEIDGEITGYNQYNQAVSADGYSSETK
                     LTITVNVRFVNNTNHEQDFEQQFSAFRVYDSRELLTAVQDGLIAEMTKEITDQIFNATV
                     ANW"
     CDS             852..1607
                     /locus_tag="ctg284_3"
                     /transl_table=11
                     /translation="MISANLQQWIQHPETLNKDTLYELRTLVTRYPYFQSLRLLYLKNL
                     YLLHDISFGAELRKAILHVADRRKLFYLIEGERYILKPRKKNALPETEVLEEEPSLDRT
                     LSLIDAFLATVPEEVSAQTSLDYATDYTTYLLQEDDTPELEETPKLRGHELIDGFIERS
                     EEETSIRLQPADENKAISEEEESETHHEEDEDDSCFTETLAKIYVKQHRYSKALEIIKK
                     LSLKYPKKNAYFADQIRFLEKLIINAKSK"
     CDS             1612..1992
                     /locus_tag="ctg284_4"
                     /transl_table=11
                     /translation="MYLLLVILMVIAAILMCFIVLIQNSKGGGLASGFSSSNQIMGVRK
                     TTDFLEKATWGLAAFMVVMSIATAYVVPTSSSKTQDVIMEQAQQEEQTNPYNLPVGTTA
                     PKTDAAAPVEAPATETPATPAN"
     CDS             2163..3551
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 97.1; E-value: 1.4e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg284_5"
                     /transl_table=11
                     /translation="MTEQLKNKLSDSKTLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACILMVLGCGLKYY
                     AISTTFPEGALIMGFKTQVFLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPIADYFGYTDESGSFHTNIPMPILLCLIMLCIGTIAFFIYTF
                     YDKKLDASLDAQGEEPEEPFRMKDVMLIVTNKGFWLIALLCVLFYSAVFPFIKYATDLM
                     VQKYNVDPKLAGNIPGLLPIGTIFLTPLFGTLYDRIGKGATLMIIGAVMLIGVHTLFAL
                     PILNVWWFATVIMIVLGIAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFACFGVLALIVALMLKAEDKKKGYGLQEA
                     NIKK"
     CDS             3558..3911
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg284_6"
                     /sec_met_domain="PF05402 (E-value: 2.1e-17, bitscore: 53.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 2.9e-10, bitscore:
                     29.8, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADVKEKINLLDVIPFRSENITAEKGSDGTVTIAFPRFKYEWMRR
                     FLLPKGMSADIHVRLEDHGTAVWELIDGKRTVRRIIEELAEHFNYEENYESRITAYITQ
                     LQKDGFVKLVIEN"
     CDS             complement(4045..5100)
                     /locus_tag="ctg284_7"
                     /transl_table=11
                     /translation="MKKLIILTGLLLSTSAYAQTEVTAGVTRGKDYGVTYALPKTAINI
                     EVKVNKVTYTPGEFSKYADRYLRLTDVSGEPQEYWELVSVKAKSVGIPDSEHTYFVKLK
                     DKTVAPLIELTEDGIVKSINVPLSPKKSAPMQPATTQKKKINPRDFLTEEILMAGSTAK
                     MAELVAKEIYNIRESKNALVRGQADNMPKDGEQLKIMLANLEEQEAAMTEMFSGTLNKD
                     EKIFNIRLTPDKEMDNEVAFRFSKKLGIVANNDLAGEPVYITLKNLKIVNVPEDDGKKK
                     VDGIAYNVPGKAQVTLTEGKKQWFNGELPVTQFGTIEYLAPALFNKKSTVQVTFNPDTG
                     GLIKVDREEGE"
     CDS             complement(5173..6684)
                     /locus_tag="ctg284_8"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIEHEPIASIDLMERAAQALTKAITERWDI
                     TTPVTVFAGPGNNGGDALAVARMLAEKEYKVEAYLFNPKGELSADCQTNKELVEMMDNV
                     KFSEVSTQFVPPALTMDHLVVDGLFGSGLNKPLSGGFAAVVKYINASPATVVAIDIPSG
                     LMGEENTFNVKANIIRAQLTLSLQLPKLAFLFAENSEFVGEWKLLDINLSREAIEETES
                     NYALLEAEEIHALIKPRNTFSHKGNFGHALLIAGSYGMAGASILAARACMRSGVGLLTV
                     HAPIRNNDILQISVPEAIIESDASDTYFACPTDTDDYQAVGIGPGIGRSEETEAALLEQ
                     LSGCQTPLVLDADALNILANHRHALTTLPKGSILTPHPKELERMVGKCQNSYERLMKAC
                     ELARTAKVHIILKGAYSAIITPSGKCYFNSTGNPGMATAGSGDVLTGVVLALLAQGYPA
                     EEAAKIGTYVHGLAGDFARKKQGVISMTAGDIISNLPLAWRLVSE"
     CDS             complement(6728..8068)
                     /locus_tag="ctg284_9"
                     /transl_table=11
                     /translation="MNNVQQVKTYSQRKISDFLFILWAGGAALLSYSLVYALRKPYTAA
                     GFDGLEAFGMDYKVVVTIAQILGYVLSKFIGIKLISELKRENRMKFILISIILAEASLI
                     LFGLLPAPYNIGAMFLNGLSLGCMWGIIFSFIEGRRMTDILASLLGVSMVISSGTAKSA
                     GLYVMDTLNISEFWMPALIGGVALPLLALLGYALNRLPQPTAEDIAMKSKRETLNGKQR
                     WELFKNFMPFLTLLFIANVVLTILRDIKEDFLVKIIDVSQYSSWMFAQVDSVVTLIILI
                     IFGLMVFVRSNLKALSILLGLIIASMVVMAVVSFGYEQLQLNAIAWLFIQSLCLYLAFL
                     TFQTIFFDRFIACFKIRGNVGFFIAMNDFLGYTGTVIVLAVKEFLSPDINWTAFYNLMA
                     GYVGIICFVAFVCSFIYLHQRYRRENYGKTGVFRKKEEEKEVPDFVY"
     CDS             8374..9009
                     /NRPS_PKS="Domain: oMT (51-151). E-value: 1e-15. Score:
                     48.5. Matches aSDomain: nrpspksdomains_ctg284_10_oMT.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 101.8; E-value:
                     6.9e-31)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg284_10"
                     /transl_table=11
                     /translation="MNKRGFVSKILQNFRKPEGFFGRMILWGMNTGHASLAQWGMSCLQ
                     WQPEWSVLDIGCGGGANLLQILQRCPQGKAYGIDISPESVTFARKKNKKYLGTRCFIEQ
                     GGVHRLPYPDYAFDAVTAFETVYFWGNLQHAFTEVARVLKPGGSFLICCEISDPANKAW
                     TGLVEGMEIHSCDELKAILSKSGFTDTAIFRTKKEELCLVSHRQTVRL"
     aSDomain        8527..8826
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg284_10_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.00E-15"
                     /label="ctg284_10_oMT.1"
                     /locus_tag="ctg284_10"
                     /protein_end="151"
                     /protein_start="51"
                     /score="48.5"
                     /tool="antismash"
                     /translation="VLDIGCGGGANLLQILQRCPQGKAYGIDISPESVTFARKKNKKYL
                     GTRCFIEQGGVHRLPYPDYAFDAVTAFETVYFWGNLQHAFTEVARVLKPGGSFLI"
     CDS             9157..9342
                     /locus_tag="ctg284_11"
                     /transl_table=11
                     /translation="MLTSYSSLIKILLFDNQLLIFWMRSAVKFFSYIQDVRSCLFIKLP
                     LRLSIACLSTYFHILL"
     CDS             9723..10241
                     /locus_tag="ctg284_12"
                     /transl_table=11
                     /translation="METTDSDKHWYVVLTRTNSERKVRDYFQLQEVDTFLPVQNRVIER
                     EGKRIERERLLLPRMVFVHISRQEMAAVRSTLNVYDFLRDRSTGAPTCIPDAQMADFRY
                     MLDYSQDQVILTGESIPKGTRVVVAKGDLQGLRGELVRYNNKYHILVRIDMFGSAMVTI
                     PASYVRKEK"
     CDS             10776..11168
                     /locus_tag="ctg284_13"
                     /transl_table=11
                     /translation="MKNSLCNSVSSVVKKLLEYGGDGTPVYVNELTALNKELRNLCADL
                     LLQKGKSPEEEAEILVTLFKGYDTMLFNFSLENEQVVQELLDRSMTVLEKLPASVLKCQ
                     LLLECFEQMGDEELIREVKNIVNRLA"
     CDS             11192..11671
                     /NRPS_PKS="Domain: Aminotran_5 (25-155). E-value: 1.2e-10.
                     Score: 32.7. Matches aSDomain:
                     nrpspksdomains_ctg284_14_Aminotran_5.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg284_14"
                     /sec_met_domain="Aminotran_5 (E-value: 1.3e-10, bitscore:
                     30.6, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSFVFPGNIESDILGISSLPIPYMRTSSFSSLVQDCESMLLRLI
                     GCPNGRVIFYTASGTGAMDAVVTNYVSLKHKAFVVAGGSFGYRWKSLCDYYDIDVDLYE
                     VPFAKDIDYSDLEAKIALSHPDVFLCQQHETSTGQMFNLDKISYICKKYHVYDKKT"
     aSDomain        11267..11656
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg284_14_Aminotran_5.1"
                     /evalue="1.20E-10"
                     /label="ctg284_14_Aminotran_5.1"
                     /locus_tag="ctg284_14"
                     /protein_end="155"
                     /protein_start="25"
                     /score="32.7"
                     /tool="antismash"
                     /translation="RTSSFSSLVQDCESMLLRLIGCPNGRVIFYTASGTGAMDAVVTNY
                     VSLKHKAFVVAGGSFGYRWKSLCDYYDIDVDLYEVPFAKDIDYSDLEAKIALSHPDVFL
                     CQQHETSTGQMFNLDKISYICKKYHV"
ORIGIN
        1 atgtgaccga actgaaaaag cttgtacacg aaatcatgtc cgagcgcgga gcggtaacct
       61 ccaatgtcgg tacgttttat acgccggctc cggtagtagc ccctacgccc tcagtgcctg
      121 ccatcattca tccggtcaag cccaattgtc ccgatgacga tgacatacaa gataccgaag
      181 agtatgtgga agagtcgctt tcgttggacg aagtcgagaa agaaatgata cgtaaagccc
      241 ttgaaaagca tcatggcaaa cgaaaaagcg cggcaaagga tcttaatata tccgagcgta
      301 ccctttaccg aaaaataaaa gaatatggat tggaataaaa agataatgcg aatttcactg
      361 ctggttttca cactggtagt aggaatttcg tgtactgttt cttataagtt taatggtggt
      421 aatatcaatt acgataaggt aaagactatc tctattgccg actttcctat taagtcggac
      481 tatgtttatg caccgttagg cactaagttc aacgaggacc tgaaagacat tttccttcgt
      541 cagacccgtc tgaaactggt gaataacaat gccgacctcg agattgatgg agagattacc
      601 ggatataacc agtataacca ggctgtttcg gccgacggat actcttctga aaccaagctg
      661 accatcacag tgaatgttcg ttttgtgaac aatacgaatc atgaacagga cttcgagcaa
      721 cagttctcgg ctttccgtgt ttatgattcg agggagttgc tgacagccgt tcaggacgga
      781 ctgattgcgg agatgaccaa agagattaca gatcaaatat ttaacgcaac agtagcaaac
      841 tggtaattag aatgatttct gctaacttac aacaatggat tcagcatccg gaaacgctga
      901 ataaagatac tttgtacgag ttgcgaacgc ttgtcacacg ctatccttat tttcagtcac
      961 tgcgattact ctatcttaaa aatctatatt tgttgcacga tatctctttc ggcgccgagc
     1021 ttcgtaaagc catattgcat gtggctgatc gccggaagct gttttatctg attgagggtg
     1081 aacgatatat tttgaaacct cggaaaaaga acgcacttcc cgaaacagaa gttttagagg
     1141 aagagcccag cctcgatcgt acgctttccc tgatcgatgc ttttctggcc accgtgcccg
     1201 aagaggtttc agcccagaca agcctggact atgcaacaga ctataccacc tatttgctgc
     1261 aagaagacga tacaccggaa ctggaagaaa ctcccaaact tcgcggtcat gaattgattg
     1321 acggctttat cgaaagaagt gaagaagaaa catccatccg tttgcaaccg gcagatgaaa
     1381 ataaagctat ctccgaagag gaagagagcg agacgcatca tgaagaagat gaagatgata
     1441 gctgtttcac cgaaacattg gccaaaatat acgtcaaaca gcatcgatat tccaaggcac
     1501 ttgaaattat taaaaaatta agtttgaaat atccaaaaaa aaatgcttac tttgcagacc
     1561 aaatcagatt tttagagaaa ttgattatta acgctaaatc aaaataacaa aatgtactta
     1621 ttattagtta tcttaatggt tattgcagcc atactgatgt gcttcattgt gttgattcag
     1681 aactcaaaag gcggtggtct tgcttcaggg ttctcatcat ctaaccagat tatgggtgta
     1741 cgcaaaacta cagactttct ggaaaaagca acttggggct tagctgcatt tatggttgtg
     1801 atgagcattg ctactgcgta tgtcgttccg acttcttctt ctaaaacaca agatgtcatt
     1861 atggaacagg cacagcagga agagcagacc aacccttata acctgcccgt aggtactact
     1921 gcaccgaaga cagacgctgc tgctccggtt gaagcacctg ccacagaaac tccggctact
     1981 ccggcaaact aacaacagat tctttttaag aaacgataag cgaagctgca atttcaaacc
     2041 gaaacttgca gcttcgctta ttttttgccg taaaatgcat ctttttgtta ggcatacaag
     2101 gcagatttag ttacctttgt tcgcaataac acttttacta atttctgagt ttaaatatta
     2161 caatgacaga acaattgaaa aacaaattga gtgactccaa aacacttcgt tggagtgtgc
     2221 tcgctctggt cgcgtttact atgctttgcg gctatttcct caccgatgta atgtcccctt
     2281 taaagcctat gctcgagaaa gagcttctct gggatagttt ggactacgga ttctttacca
     2341 gtgcttacgg atggttcaat gtattcctgc tcatgttgat tttcggtggt attattctcg
     2401 ataagatggg agttcgtttc accggtatgg gagcttgtat actgatggtg ttgggttgtg
     2461 gactaaaata ttatgctatc tctactactt ttcctgaggg agctttgatt atgggtttca
     2521 agactcaggt ctttctggcg gctttaggat acgctatctt tggtgtcggc gtagagatcg
     2581 ccggtatcac tgtctctaag attatcgtga aatggtttaa aggtaaagag atggctttgg
     2641 ctatgggact tgagatggca accgcacgta tcggtaccac tttggctatg gtgcttaccg
     2701 ttcccattgc cgattatttc ggctatacgg atgaaagcgg cagtttccat accaatattc
     2761 cgatgcctat tttgttgtgc ctgatcatgc tgtgcatcgg tactatcgcc tttttcattt
     2821 atacctttta tgataagaaa cttgacgctt ctttagatgc tcagggagaa gaaccggaag
     2881 aaccgttccg tatgaaggac gttatgctga ttgtcaccaa taaaggcttc tggctgattg
     2941 ctttattgtg tgtactattc tattctgctg ttttcccctt tattaaatat gcaaccgact
     3001 tgatggtgca gaagtataac gtagacccta agctggccgg aaatattccg ggattactac
     3061 cgataggtac catcttcctg actccgttgt ttggtactct ttatgaccgt atcggtaagg
     3121 gagcgacgtt gatgattatc ggtgccgtca tgctgattgg tgtgcatact ttgtttgcgc
     3181 ttcccattct gaacgtatgg tggtttgcca ctgtgattat gattgttctg ggtattgctt
     3241 tttcactggt gccttcggcc atgtggcctt ctgttccgaa aattattccg gagaaacaac
     3301 tgggtactgc ctatgctttg attttctggg tgcagaactg gggattgatg ggggtacctc
     3361 tgttgatcgg atgggtgttg aatacctatt gcaaaggtcc tgttgtggat ggagcgcaga
     3421 cttatgacta tactttgcct atggctatct ttgcttgttt cggtgttttg gctctgattg
     3481 tagctttaat gttgaaagcg gaagacaaga agaagggata cggactgcag gaagcaaata
     3541 tcaaaaaata acagtatatg gcagacgtga aagagaaaat aaatcttctg gatgtaattc
     3601 ctttccgtag tgaaaatatt acggccgaaa agggaagcga tggtaccgtt accattgctt
     3661 tcccccggtt taaatacgag tggatgcggc gattcttgtt gcctaaagga atgtctgcgg
     3721 atattcatgt ccggctggaa gatcatggca ctgccgtatg ggagttgatt gacggaaaga
     3781 gaaccgtacg ccggattatt gaagagctgg cagaacactt caattatgaa gaaaattacg
     3841 aatcacgtat tacggcttat atcactcagt tgcagaaaga cggatttgtg aaattagtga
     3901 ttgagaactg attgcattac gatatactat cggaatataa taaagagact ccggctgatt
     3961 taaaaatgaa gtgcacccta aaagttaaac atgaactttt ggggtgcact tcatttaaga
     4021 tcggccggag tttttgatta tgttttattc tccttcttct ctatctacct tgatcaagcc
     4081 tcctgtatcc gggttgaaag taacctgaac agtcgatttc ttattgaaaa gcgccggagc
     4141 cagatattcg atggtaccga attgtgtgac aggaagttct ccgttaaacc attgcttttt
     4201 cccctccgtt agtgttactt gtgctttgcc gggcacatta taggcaatgc cgtccacctt
     4261 ctttttgcca tcgtcttccg gtacgttgac gattttcaga ttcttcagcg tgatataaac
     4321 cggctctcct gcaagatcgt tattagcaac tatgcccagc ttcttcgaaa agcggaaggc
     4381 tacttcgttg tccatttcct tatccggagt gaggcggatg ttgaatatct tttcgtcttt
     4441 attcaaggta cccgagaaca tttcggtcat ggcagcctct tgctcttcca ggttggcaag
     4501 cataatcttc agttgctccc catctttggg catgttgtct gcctgtccgc gtaccagggc
     4561 atttttactt tcacgaatgt tataaatctc tttggcaacc aactccgcca ttttagctgt
     4621 agaacctgcc atcagaatct cttcggtcag aaaatcacgt ggatttatct tctttttctg
     4681 tgtcgtggcg ggttgcatcg gagccgactt tttaggagat agcggtacgt tgattgattt
     4741 tacgatacca tcttcggtca attctattag cggagctact gttttatctt tcagcttgac
     4801 aaaataggta tgttcgctat cggggatacc gacagatttt gctttgacgc tgaccagttc
     4861 ccaatattcc tgaggctcac ccgacacatc ggtcaaccgg agataacggt cggcatactt
     4921 gctgaattct cccggagtat atgtcacttt attgactttg acttcaatat tgattgctgt
     4981 tttaggaagt gcataggtta caccgtaatc ttttccccgg gtaactcccg ctgtaacttc
     5041 ggtctgggca taagccgagg tagagagtaa cagccctgtc agtataatta gctttttcat
     5101 ttccggttta ttttaactgg tttaaaaaac aaagttaatg aagttatttg gaaaatcata
     5161 agttgttaac ttttattcgc ttaccagacg ccaagccaat ggcagattac tgataatgtc
     5221 tcctgccgtc atgctgataa cgccttgctt tttgcgtgcg aaatcacctg ccagaccatg
     5281 tacataagta ccgattttgg cagcttcttc agccggatat ccctgtgcga gcaaagccag
     5341 cacgacacct gtcaatacat ctccgcttcc ggctgttgcc atacccggat tacccgtaga
     5401 gttgaaatag cacttgcccg agggggtgat aattgccgaa taggctcctt ttaatatgat
     5461 atgtactttg gcggttcggg ccagttcaca ggccttcatc agtcgttcgt atgagttctg
     5521 gcatttgccc accatgcgtt ccagttcttt gggatgggga gtcagaatag agcctttggg
     5581 caatgtggtc agtgcgtggc ggtggttggc caatatgttt agtgcatcgg catccagtac
     5641 cagaggtgtc tggcaaccac tgagttgttc aagcagtgca gcttcggtct cttccgagcg
     5701 tccgatgccc ggaccgattc ctacagcctg atagtcatcc gtatctgtag ggcaggcaaa
     5761 gtaggtatcg ctggcatccg attcgataat tgcctccgga accgaaatct gcaggatatc
     5821 attgttgcgt ataggtgcat ggactgtcag taagcctaca cccgaacgca tacaggcgcg
     5881 ggctgccagt atcgacgcgc ctgccatgcc gtacgaaccg gcaatcagca gagcatgccc
     5941 aaagtttcct ttgtgtgaga aagtgttacg gggtttgatc agagcgtgta tttcttccgc
     6001 ttccaataag gcataattgc tttccgtttc ttcaatcgct tcacgactga ggttgatatc
     6061 caacagtttc cattcgccta cgaattcgga attttcggca aagaggaaag ccagtttcgg
     6121 caattgcaga ctcaatgtca attgggcacg gatgatattg gcttttacat taaatgtgtt
     6181 ctcttctccc atcagtcccg aggggatatc gatggcgact acggtggcag gcgatgcatt
     6241 gatatatttc actactgccg caaaaccgcc acttagcggc ttattaagtc ccgaaccaaa
     6301 aagtccgtcc actactagat gatccattgt cagggcagga ggtacaaact gtgtgcttac
     6361 ttcgctgaac ttcacattat ccatcatctc taccagctcc ttgttggtct ggcagtcggc
     6421 agacagttcc cctttcgggt taaacagata ggcttcgacc ttgtattcct tttccgccaa
     6481 cattcgggct acggcaaggg catctccgcc attgttgccc ggtccggcaa ataccgtgac
     6541 gggagttgtg atgtcccagc gttcggtgat ggctttggtc agtgcctgtg cggcccgctc
     6601 catcaggtcg atcgatgcaa tcggttcatg ttctatggtg taagcatcca gtttcttgat
     6661 gctgctactt ggaaaaatct tcatggtgaa ctttcatttt aagttttttg acccacaaag
     6721 atagcaatta atatacgaaa tcgggaactt ctttttcttc ttcttttttt ctgaataccc
     6781 ctgtctttcc gtaattctcc ctgcggtagc gttggtgcag gtagatgaaa gagcatacaa
     6841 aagcaacgaa acagattatt cccacatatc ctgccatcag attgtagaaa gctgtccagt
     6901 taatgtccgg tgacaagaat tctttgacag ccaatactat gactgttccc gtatagccca
     6961 gaaaatcatt catagcaatg aagaaaccca cgttacctcg aattttgaag caagcgataa
     7021 aacggtcgaa gaagatagtc tggaaagtga gaaaagccag atagagacac agactctgga
     7081 tgaatagcca ggcgatggcg ttcagctgca attgttcgta accaaacgaa acgactgcca
     7141 tcactaccat gctggcaatg atcaatccca gtaatatcga cagtgctttc aagttgcttc
     7201 tgacgaacac cattaatcca aaaattatca gaataatgag ggttactacg ctgtctacct
     7261 gtgcaaacat ccacgaagag tattgagaga catcgataat ttttaccagg aagtcctcct
     7321 ttatatctct caagatagtc agtaccacat tggctataaa gagcagagtg aggaaaggca
     7381 tgaaattctt aaatagctcc catcgttgct tgccgttcag tgtttcccgt ttcgatttca
     7441 tggcaatgtc ttcggctgtt ggctgtggaa gccggttgag tgcatatccc aacaaggcaa
     7501 gtagaggaag ggcaactccg cctatcaggg caggcatcca gaattcgctg atgttcaaag
     7561 tgtccatgac atacaaaccg gccgacttgg cggtacccga gctgatgacc atactgactc
     7621 cgagtaagct ggcaagaatg tccgtcattc gtcttccctc gataaagcta aaaatgattc
     7681 cccacataca tcccagtgaa agtccgttca gaaacatggc tcctatatta taaggtgcgg
     7741 gcaacagtcc gaacaatatt aacgaagctt cagccagaat tatggagatc agaataaact
     7801 tcatccggtt ttcccgtttt aattcggaga ttaatttaat tccgatgaat ttagaaagta
     7861 catatcctaa tatttgtgcg atggtaacta ccactttgta gtccattcca aacgcttcaa
     7921 gtccgtcaaa tccggctgct gtataaggct ttctcagtgc atataccaat gaataggaga
     7981 gcagcgctgc tccgcctgcc caaagaatga aaaggaaatc agaaattttt ctctgcgaat
     8041 aagtttttac ttgctgtaca ttgttcataa catctgcttg ttgttttccg gtgcaaaaat
     8101 aggagggtag tgttacagac ctgttactga atatatgaat gtttattatt aatagatatt
     8161 gataatgaat ctgttatgtt gtaatgttta tgtaatattt atgaaacgga aacgaaaaga
     8221 gcatcgcacc tccgggcatc tgttcgtcat aattttaacg ggaagcagat gcatacctgc
     8281 aaatatattt taggaaataa attccctatt tctgggtatt gcctgtttgg gcagaaactg
     8341 tacttttgcc tgaaatatta aatcagcaga caaatgaata agagaggctt tgtaagcaag
     8401 atcttacaga atttccggaa gcctgaaggt tttttcggaa gaatgatact ttgggggatg
     8461 aatacaggac atgcatcatt ggcgcaatgg ggaatgtcat gtttgcaatg gcaaccggaa
     8521 tggagtgtac tcgacatcgg ttgcggtggt ggtgccaatt tgctacagat attgcaacgt
     8581 tgcccgcaag ggaaagcgta tggcatagat atttcaccgg agagtgtcac ctttgcgcgt
     8641 aaaaaaaata aaaagtatct cggtacacgc tgctttatcg agcagggagg agtccaccga
     8701 cttccctatc ctgattatgc gttcgatgcg gtcactgctt tcgagactgt ctacttctgg
     8761 ggtaacctgc agcatgcttt tacggaagtg gcgcgtgtgt taaagcccgg tggatcgttt
     8821 cttatctgtt gtgagataag cgatcctgcc aataaggctt ggacgggact tgttgaaggg
     8881 atggagattc attcctgtga tgaactgaag gcgattcttt ccaaaagtgg ttttaccgat
     8941 acggccatat tccggacgaa gaaagaagaa ctgtgcctgg taagccatcg gcaaactgtg
     9001 cggttgtaac caatgccggg acgctcttac caacgaatac gttaacaatg ttaatgcccg
     9061 taaaagtgct ttccctcctt gtcaatagct tattaacttc gtatctctaa agaattaata
     9121 tcttgcaatt acgaagttaa tattaacgta ctgttaatgt taacttccta cagttctctt
     9181 attaagatat tattgtttga taatcaattg cttatattct ggatgcgttc tgccgtaaaa
     9241 ttcttctctt acattcaaga tgtgcgtagt tgtctgttta tcaagttacc gttaagactc
     9301 tccatagcct gcctctccac ttatttccac attcttttat aagccacatt agtattatgt
     9361 atattgctgc tttccttatt tgcaaagaga taaattatat ctttgatatt cagttatata
     9421 acttcctatg atgaaaataa tctgtgaaaa gttttggaga ctcaaaagaa ggttttacct
     9481 ttgcacccgt aaatatatag gcggacaaat atacttttct ttatgtccga tatatgttta
     9541 aaataaaata attcaacgta tcggatagta ttcaaatccg gtgcgaatac tttttctgta
     9601 cccgattatc ataaaactta atttgtaaat tgctgaaaat aaggcgtgtt ttttgaatat
     9661 tcctgttttt aacaaatttt catccttagt cattactgaa actttttctt acgaacgtag
     9721 tcttggagac aacagatagc gataaacatt ggtatgtcgt actgacacga actaactcag
     9781 aacgtaaagt tcgggattat tttcaattgc aggaggtaga tacctttctt cctgtacaaa
     9841 accgtgtcat agagcgtgaa ggaaaacgca ttgagcgtga gcgccttttg ttgccccgta
     9901 tggttttcgt tcatatctcc cgtcaagaaa tggccgccgt ccgaagtaca ctgaatgtat
     9961 acgatttcct tcgtgatcgt tccaccgggg ctcctacctg tattcctgat gcgcaaatgg
    10021 ctgattttcg ctatatgctc gattactccc aggatcaggt gatcctgaca ggagagtcca
    10081 ttcccaaagg tactcgtgta gtagttgcca agggcgattt acaaggcttg cggggagaat
    10141 tggtccgcta taataataaa tatcatattt tagtacgtat cgatatgttc ggtagcgcta
    10201 tggttacaat tccggctagc tacgtccgga aagagaaata aaaagtatat atgtgaagaa
    10261 aataccatta tatgtaatgg cgataacaat atatgtaacg ggtgataaca atatatgtaa
    10321 tgccccgtta cgtcgttaga tataattcta ttggatatta ttactcttct tcaggtttcg
    10381 gaagtgcaag tgctcgttta tagttgacaa aaaagtaagt atcccggctt tcgaccgaaa
    10441 aggctatcgg tgagaggaaa aagcgaattt aacacttaac tgtttgaaaa gtaatgcttt
    10501 caaagtacaa gccttctgtc tacaaaagtt tcgttttaac acagtgttaa agcttgttct
    10561 ttagatgcaa ataacgagtg ttttaaatgc aaaaggcttg ttgtttacgc acaagaacca
    10621 aacagtctaa aaaagacgtt aacaatgtta attgaagaaa ggcataagta tatcggttca
    10681 gacggcgtaa atctacttct gaaactgaag ttactttttc tatataaata aaaaccgaaa
    10741 aagaatcgac gaatcataat tcattccttt ttaaaatgaa aaattctctg tgtaattctg
    10801 tgtcctccgt agtgaagaaa ctcttggagt atggcgggga cggtactcct gtctatgtga
    10861 atgaacttac tgcgttaaat aaagaactcc gtaacttgtg tgccgatctt cttcttcaga
    10921 aaggaaaatc ccccgaagaa gaggcggaaa ttcttgttac tttgttcaaa ggttacgata
    10981 ccatgctgtt taatttctcc ttagaaaatg aacaggttgt tcaagaatta ttggatcgtt
    11041 caatgactgt tttagaaaaa ctaccagcct ctgtattgaa atgtcaattg ctgctggagt
    11101 gctttgaaca gatgggagat gaggagctga taagagaagt gaaaaatatt gtaaatcgat
    11161 tagcttagta gttttaaaat ttgagttatt tatgaattct tttgtatttc ctggtaatat
    11221 agagtcggat atccttggta tttcttctct tcccattccc tacatgcgta cttcctcttt
    11281 ttcatctttg gtgcaagatt gtgagagtat gttgcttcgt ttgattggtt gccctaatgg
    11341 gcgggttatt ttttatacag cttccggaac aggtgcgatg gatgcagttg taaccaatta
    11401 tgtttctcta aagcataaag cttttgttgt tgctggcggt tcttttggtt atcgttggaa
    11461 aagtttatgc gactattatg atattgatgt tgatttgtat gaagtgcctt ttgcaaaaga
    11521 tatagattac tcagatcttg aggccaagat tgcattatcg catccagatg tgtttctttg
    11581 ccagcagcat gaaacctcta ctggacaaat gttcaattta gataaaatct cctatatttg
    11641 taaaaaatat cacgtttatg acaagaaaac a
//
