LOCUS       c00470_gnlPro..        17344 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GAHIDPKH_470.
ACCESSION   c00470_gnlPro..
VERSION     c00470_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 07:53:25
            Original ID  :: gnl|Prokka|GAHIDPKH_470
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17344
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17344
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3885:7344]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3886..7344
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..17344
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..17344
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             2..1501
                     /locus_tag="ctg470_1"
                     /transl_table=11
                     /translation="VDTVNENKLVESAIIEMLAQLDPHSTYSDAEEVKKMNEPLQGNFE
                     GIGVQFQMIEDTLLIVQPVSNGPSEKVGILAGDRIIAVNDTAIAGVKMGTEEIMGRLRG
                     PKDSKVNLTIIRRGVKEPLLFNVKRDKIPILSLDAAYMIQPKIGYIRINRFGATTAEEF
                     LKALKELQKKGMKDLILDLQGNGGGYLNAAIDLANEFLGQKELIVYTEGRSAQRSEFFA
                     KGNGNFRNGRLVVLVDEYSASASEIVTGAIQDWDRGVVVGRRSFGKGLVQRPIDLPDGS
                     MIRLTIARYYTPAGRCIQKPYDSSINEKPGKGKSSESSIEKYNQDLIDRYNHGEMVSAD
                     SIHFPDSLKCQTKKLGRTVYGGGGIMPDYFVPVDTTLYTDYHRNLVAKGVVIKTTMNFI
                     EKNRKALLDKYKTFEKFNEKFEIDDQLLNYLREAADKEKIEFNEEQYNKALPLIKAQLK
                     ALIARDLWDMNEYFQVMNATNKSVERALEILNDKEYEKILK"
     CDS             complement(1585..2208)
                     /locus_tag="ctg470_2"
                     /transl_table=11
                     /translation="MKKFVLICFCVLSSVGGYAQNWDINTLHKINSLDSKFARNYSKAF
                     SKSAPYIAVGVPVAMAVYAGIDKDKELLKDAIYIGTSVAEAVVITYGMKYAFDRERPYD
                     RYPDRVDARSHESSPSFPSGHTAAAFSLATSLSIRYPKWYVIAPSAFWACSVGFSRMNE
                     GVHYPSDVAAGAVIGAGCAVANIYVNRWLNKWLFGEKKKVTISY"
     CDS             2324..3199
                     /locus_tag="ctg470_3"
                     /transl_table=11
                     /translation="MARETQCNRQTDCAQCPKATEGILVHRKFPKGQHFPPDKCTQNCI
                     LFILQGELLVNSEEYPGTTLREGQFILQSIGSKLELLALTDVNYVVYWFNEPPLICEQR
                     YHEILQQSEAPLTYTPLVMTQRITNFMKDICDYLDEQMPCGAFIDLKCQELMYLIICYY
                     PIPQLSKFFYPISSYTESFQYFVMQNYEKVKNVEEFAHLGGYTTTTFRRLFKNMYGVPV
                     YEWILSKKREGILEDLQHTKQRITEISNRYGFDSLSHFAHFCKASFGDSPRALRTRAAR
                     GEKITALKTE"
     CDS             3886..4578
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg470_4"
                     /sec_met_domain="SucD_FumR (E-value: 6.3e-121, bitscore:
                     392.4, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWLSNSSVGRKVVMSVTGIALVLFLTFHMAMNLVAIISAEGYNLV
                     CEFLGANWYALVATLGLAALFVIHIIYAFWLTIQNRAARGSERYAVVDKPKTVEWASQN
                     MLVLGIIVILGLGLHLFNFWAKMQLPELVHNMGGVADTTYAADGVYHIMNTFSNPVYVV
                     LYLVWLGALWFHLTHGFWSSMQSLGWNNKIWINRWKCISNIYSTIVVVCFALVVVVFFV
                     KSLACGAC"
     CDS             4616..6559
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 197.1; E-value:
                     1.8e-60)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg470_5"
                     /sec_met_domain="FAD_binding_2 (E-value: 9.9e-61, bitscore:
                     197.1, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 5.4e-38,
                     bitscore: 121.1, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKIDSKIPEGQLAEKWSNYKAHQKLVNPANKRRLDIIVVGTGLA
                     GASAAASLGEMGFRVFNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKG
                     GDYRAREANVYRLAEVSNAIIDQCVAQGVPFARDYGGTLDNRSFGGAQVSRTFYARGQT
                     GQQLLLGAYSALSRQVQKGTVKLYTRYEMLDLVVIEGRARGIIARNLVTGEIERFAAHA
                     VVIGTGGYGNAFFLSTNAMGSNGSVAIQCYKKGAYFANPCFAQIHPTCIPVHGDKQSKL
                     TLMSESLRNDGRIWVPKKIEDAKALQAGTKKPTEIPDEDRDFYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNNTGLAVFLDFKYAIDRLGEDVVRARYGNLFDMYEEITDENPYK
                     TPMMIFPAIHYTMGGIWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYF
                     VLPYTIQNYLADQIQVPRFSTDLPEFAAAEKEVKDKIQKIKAVNGKHSVDSIHKKLGHI
                     MWDFVGMARTKESLQKALTGIEEVKKDFWTNVRIPGDVNELNVELEKALRLIDFIEVGM
                     LMARDGLNREESCGGHFRTEYQTPEGEALRDDKNFSYVACWKYTGENSEPELIKEDLNY
                     QFVKVQTRNYKS"
     CDS             6589..7344
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg470_6"
                     /sec_met_domain="Fer4_7 (E-value: 3.3e-12, bitscore: 38.1,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_3 (E-value: 4.3e-26, bitscore: 82.3,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1.3e-06, bitscore: 20.0,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKNISFTLKVWRQKGPKAKGAFETYQMKDIPGDTSFLEMLDILN
                     EQIINDGGEPIVFDHDCREGICGMCSLYINGHPHGPATGATTCQMYMRRFKDGDTITVE
                     PWRSAGFPVIRDLMVDRSAYDKIMQAGGYVSVNTGAPQDANAILISKDIADEAMDAAAC
                     IGCGACVAACKNGSAMLFVSAKVSQLNLLPQGKVEAARRAKAMLSKMDELGFGNCTNTR
                     ACEAECPKNISISNIARLNRDFIIAKLKD"
     CDS             complement(7425..8024)
                     /locus_tag="ctg470_7"
                     /transl_table=11
                     /translation="LTLKRPFTFSRLNFDLHNVAGFYAALVLAVLCFTGLIFSLNWFSR
                     GVYSITSGGEELKPYVLPVSDTLQVVNRVTNPLDRLYTQLRLEEPAAKTFYFALPGQAD
                     GVYRVSVVHKRGSYYRTDNLFFDRYTLVSLKGAGPYAGKYTEASPADKFRRMNLEIHDG
                     RIWGLPGKIIMFLASLTGASLPVTGFIIWYRKRRKR"
     CDS             complement(8562..9782)
                     /locus_tag="ctg470_8"
                     /transl_table=11
                     /translation="MITMYRIYMYLLAACLLLGVTACEEEGLGNEETPFAPYVLSLGIN
                     SNGTTTYYVVTAPELMSGTINAVAKGIEQNGYRDYEQAGQTVFSIGGLGLTSATGIVRD
                     ANGYLTERGDFVFNSSLNAFTQMDGQNMIGLELPANKESGDQMTLYTVNISDVSITSQV
                     KAPVFPLNQLEWPSITGMCYSEGNVYVTYFPMNPSTFETLYTDTTFVAVYSYPDMQFKT
                     LMKDTRTGPAGSWNAFNGIFKVESGDMYIMSNSAIANGFSQSTKNAAFLRIPKGETHFD
                     DYYFDFETVSGGLKPAHIKYIGNGLVFAEVSTISPQTSADRWGDKSLKCCIIDLNNKTV
                     RDIKEIPVHNGDGGRRFAALVDGGYVYRPVTTSEGTYIYQVDPQAATAVRGAKVSTTFV
                     GGFFRLD"
     CDS             complement(9792..12209)
                     /locus_tag="ctg470_9"
                     /transl_table=11
                     /translation="MNHKVLYRVALFCLFSMLSAVLMHAGEQQQQSKGIVTGRIVDQQK
                     QPYYPVAVAIEGVYIGGYTNENGVYHINDVPAGSQTIVVSGIGVKTKKVPIHVTAGKVN
                     RIPDIEIDTQAEELEEVQVIGKSEARRQQEQAYAISVLDIKKAYNSAAPLNKLLNNVSS
                     VRIREEGGMGSNYNFSLNGFSGNQVKFFLDGIPMDNFGSSFNLANISANMAERVEVYKG
                     VLPVNLGADALGGAVNIVSRRDANYLDATYSFGSFNTHKVSVNGAYTHLKTGFTVRANA
                     FYNYSDNDYKVFVPIIDLATNKKIDERWVRRFNDAYRSGGIRLETGITNKPYADYLLAG
                     IILSKNDKDVQTGATMDAVYGGVKMKSESVIPSIRYKKDDLFLDGLSLSLYGTYNSVNT
                     FNVDTIARRYNWLGESVPSTSAGEGYYTDSKIKNREWLGNGNISYVIDGHQSLILNHVV
                     SAMRRTMNDKVRPDDENNNVPQQLTKNITGLGWQIRYDRWNANVFGKMYKLYSSTYKRL
                     DEYTENARWEKVRDHKTNFGYGAAATYYILPSLQAKFSYEHAYRLPESIEMFGDGLIQQ
                     RNPDLKPESSRNLNLGLSFIQTFGAHQLSADGNFIYRYTTDFILKGVSLTSNPTTGYEN
                     LGKVLTKGVEAAVRYNYKDLFHTGAGFTYQDITDRQRYEKTKDSFVGEGITENITYKER
                     LPNIPYLFANADAGVRFHDLIWKNSVLTFDYNLNYIHSYYLSFPGLGAKSSKKVIPEQF
                     SHDLALGYSMDNGKYSVVVECTNLTNQKLYDNYRLQKPGRAFNVKLRYFFSK"
     CDS             complement(12342..13187)
                     /locus_tag="ctg470_10"
                     /transl_table=11
                     /translation="MPSSVCGDPMMCQNCKKSVPNAIFHVYHRRGFHYPAQKCEENFIL
                     FLIKGEMLVNSREYAGTMLKAGEFMLQPISSKIEMLAMTDVECIYYQFNQPELFCDIRY
                     NRIMKETDPPLIPSPLPIIPELQHFLESARTYLSEKKICRDLLSLKRKELAFILGYFYS
                     DYDLASLVHPLSKYASSFECFVYQNYKKVKTVEEFAKLGGYSQTTFRRIFDNVFHEPVY
                     EWMLSRRKEEIIYELQNTEATISEICYKFGFESLPHFSNFCKKSFGTSPRSIRLKRSSE
                     "
     CDS             complement(13336..13893)
                     /locus_tag="ctg470_11"
                     /transl_table=11
                     /translation="LVIAKATNLLKEANTGGVSLTFAHALTQINFSVKLVQNFTYKITE
                     IKIENVANEGTLGFENTTWTSQKGSEAYIYNVTYNSSGYNPKETSEETVDFSTADNALM
                     LLPQLFDDSSAAAISVAYTVTASNGQTTFTGTKKVELKNSTAWGEGKKIRYTLTLPTGA
                     DAISFTPTVGGWTDDSREESAK"
     CDS             complement(14380..15327)
                     /locus_tag="ctg470_12"
                     /transl_table=11
                     /translation="LLCMVLLSFLVVTGCSRRDILDDYPVSGVEVRLDWSGVTEKLPEG
                     VRIIFYPKDEKGRKIDTYLSVTGGEVKVPSGHYAVVIYNYDTETVLIRGEESYETIQAY
                     TNFCKLGIAGTEKMVWGPDPLYVVNIDDLDIQNSEETLILKLKPKLVIRTYSFSIKVQG
                     LSNVSNVIGSIGGMADHYFLGKAYAMCDDYPINIDLNVKAGKIEGVFTTFGLPEAIITR
                     LEIKLPVMMNLMIIKVDNSVQEVKINITEAVQEPTGGGEGGEGEETKPPALVEVEIEDE
                     IKVDDVETPPDGNGGMNGDVDDWEDETDIVIPVE"
     CDS             complement(15352..16323)
                     /locus_tag="ctg470_13"
                     /transl_table=11
                     /translation="MENRICILTLFVFLFLLSGESRAMVAMPDAWTRMMIGVNQKDWSL
                     LRERVQADLHVPDREDVLMLIDYHRDDRMKCENLLRRLNGGEAYRYIMNKILPLLYVYR
                     EHSPVPIPDDKAAGVFLSTANVLPRVKFVHPQPVVPEEGKIETPVIIEQRTVLALKNNL
                     LYDLALAPNIEVEIPLNRRWSVNAEYKCPWWLNSSREFCYQLLSGGVEGRCWLGNRKRR
                     NRLAGHFIGAYAEGGIYDFQFKGDGYQGRYYAASGLTYGYAKQIARHLSFEFSLGIGYL
                     TTEYKKYTPYEGDLVWKSSARYNFIGPTKAKVSLVWLITARR"
ORIGIN
        1 tgtagatacg gtcaatgaaa acaaactcgt tgaatcggcc atcatagaaa tgctggcaca
       61 actcgaccct cattccacct attcggatgc cgaagaggtg aagaaaatga atgaaccgct
      121 ccaaggcaat ttcgaaggga taggtgtaca gtttcagatg atcgaagata cgctgctcat
      181 cgtacaaccg gtgagtaatg gcccgtccga aaaggtaggt atcctggcag gagaccgtat
      241 catcgcggtg aatgacacag ccatagcagg cgtaaaaatg ggaacagaag aaatcatggg
      301 acgcctgcgg ggccccaaag attcgaaagt aaacctgacc attatccgca gaggtgtgaa
      361 agaaccgctt ttatttaatg taaaacgaga taaaattcca atcctcagcc tggatgctgc
      421 ttatatgatt cagcctaaaa taggatacat ccgtatcaac cgttttggag caactaccgc
      481 cgaagagttt ctaaaagccc tgaaagagtt acagaaaaaa gggatgaaag acctgattct
      541 ggacctgcaa ggcaacggag gtggttatct gaatgccgcc atcgatctgg caaacgagtt
      601 cctgggacaa aaagaactga ttgtctacac agaaggacgt tctgcacaac gcagtgagtt
      661 ttttgccaaa ggtaacggaa acttccgtaa cggacgtctg gtggtattgg tagacgaata
      721 ttcggcttcg gcaagtgaga ttgtgacagg tgccattcag gattgggaca gaggagtggt
      781 ggtaggacgc cgttctttcg gtaaaggact ggttcaacgc ccgatcgacc ttccggacgg
      841 ttctatgatc cgcctgacca ttgcccgcta ctatacacct gcaggacgtt gcatacaaaa
      901 gccttatgac agcagcatca acgaaaaacc gggaaaagga aaaagcagtg aaagcagcat
      961 cgaaaaatac aaccaggatc tgatcgaccg gtataatcat ggcgaaatgg tcagtgcaga
     1021 cagcatccac ttcccggatt cactgaaatg ccagactaaa aaactgggac gtacggttta
     1081 tggtggagga ggtatcatgc cggactactt cgttccggta gacacaacgc tgtataccga
     1141 ctatcaccgt aacctggtag ccaaaggggt agtcattaaa accacaatga acttcattga
     1201 aaagaaccga aaggctttat tggataaata taagacattc gagaaattca atgaaaagtt
     1261 tgaaatcgac gaccagctat tgaactacct gagagaagct gccgataaag aaaagattga
     1321 attcaacgaa gagcagtaca acaaagccct gccactgatt aaagcgcagc tgaaagcttt
     1381 gatagcccgt gacttatggg atatgaatga atatttccaa gtaatgaatg ccaccaataa
     1441 gagtgtggag cgggcactgg aaatcttaaa tgacaaagag tacgaaaaga tattgaaata
     1501 acgtttctat aacggaaaac gatatacggt gaatgacgaa cagaccatgc ttcctgcagc
     1561 ctgttcgtca ttcaccgtat gtcgtcaata acttattgta accttcttct tctcaccgaa
     1621 caaccacttg ttaagccagc gattcacata aatattggct accgcacaac cagctcctat
     1681 cacagctcct gctgctacat ccgacggata atgtacccct tcattcattc ttgagaatcc
     1741 cacagaacat gcccagaaag cagatggagc tatcacatac catttaggat aacggatact
     1801 caaagaagta gccagtgaaa aggctgctgc cgtatgaccg gaaggaaacg aaggactcga
     1861 ttcatgacta cgtgcatcta cccgatccgg ataacggtcg tagggacgct cacggtcaaa
     1921 agcatatttc ataccatacg taatcacgac tgcctcggcc acactcgtac cgatgtaaat
     1981 ggcatctttc agcagctctt tatctttatc gatacctgca tatacagcca tcgccaccgg
     2041 tacacctacc gcaatataag gtgccgattt agaaaaggct ttgctataat tcctcgcaaa
     2101 cttactatca agactgttta ttttatgtaa cgtattgata tcccagttct gagcatatcc
     2161 ccctaccgaa gaaagcacac aaaaacaaat aagcacaaat ttcttcattt ttctactaat
     2221 ttactatttt gcagcaaaga tagattaaaa agacagagtt ttcgcaaaaa aaacctatct
     2281 ttgttcccta agtattattt accctgacac ctaactttaa ttcatggcca gagaaactca
     2341 atgtaataga cagacagatt gtgcgcaatg tcccaaagct acagaaggca tacttgttca
     2401 ccggaagttt cccaaaggac aacattttcc gcccgacaaa tgcacacaaa attgtatcct
     2461 gtttatacta caaggagaat tactggtcaa cagtgaagag tatcccggca ccacattacg
     2521 tgaaggacaa tttattctcc agtccatcgg ctccaaatta gaattactgg cactgacaga
     2581 cgtaaattat gtagtgtact ggttcaacga accacccctg atctgtgaac agcgctatca
     2641 tgagatcctg caacaatcag aagctccgct aacttataca ccattggtta tgacacaacg
     2701 cataaccaac ttcatgaaag atatttgtga ttacctcgat gaacagatgc cttgcggcgc
     2761 attcatcgat ctgaaatgtc aggaactgat gtatctgatc atctgttatt acccgatacc
     2821 ccagttgagc aagtttttct atcccatcag cagctatacg gaaagtttcc aatatttcgt
     2881 catgcagaat tacgaaaagg tgaaaaacgt agaggaattt gcacacctgg gaggctatac
     2941 cactaccact tttcgccgtt tattcaagaa catgtatggc gtacctgtat acgaatggat
     3001 tctgagcaag aaaagagaag gcatcctgga agacctccag cataccaaac aacggatcac
     3061 cgagatcagt aatcgttacg gattcgactc tttatcacat tttgcacatt tctgcaaagc
     3121 ttcctttgga gactctccac gtgcccttcg tacacgtgca gccagaggtg aaaaaattac
     3181 tgctttaaaa acagaataga aaccgctctt tttacccgat aacggacaaa gcttcatccg
     3241 aatccccttc tcattcttcg gatcagtcgg atacttctcc cacgtaaatg gatttcaatc
     3301 ttccatcttc caccctccga acaagagctg ggatacaaca catcatgctg atatccaaat
     3361 gtatataact atatctctat ctatttatat cacttagagt attttatttt tcttgctatc
     3421 tttagtgaaa atggtctttt ctttatctcc tcctgcatat ctgtgcccat gagcccagat
     3481 agcaaggctc acataaacat atcagaaggt acggtaatac tcttatttac aaagtattat
     3541 aaatgatgtc catttgactt gttttcttct taattcatgc acagaaaaga gaattagagg
     3601 aaacctcgga aaacgaccaa ttaaatataa gcatgataac gactccaaaa gctaacttct
     3661 taaagacaaa gattttacta ttctaacaga ttcacgacaa atcctttata cccccaaccg
     3721 atcgtcccgt ttaccccatc ctctccggac attcaggatt aaagaattat ttctttaatt
     3781 ctttggttaa tcaatgtatt tcgtgtactt ttgcacaatg agaaagaagg ctcgtaaaac
     3841 agaaattata gttctaacaa ttaaataatt taaaatcaat catttatgtg gttaagtaat
     3901 tcatctgtag gaaggaaagt ggtgatgagc gttaccggta tcgcccttgt cctgtttcta
     3961 acgtttcaca tggcgatgaa ccttgttgcg atcatctcgg ctgagggtta caacttggtt
     4021 tgtgagttcc tgggagcaaa ctggtatgcg ttggtagcta cgctgggcct ggctgccctc
     4081 ttcgtgattc acattatcta cgctttctgg ctgacaatac agaatcgcgc agcacgtggt
     4141 agcgaacgtt acgccgtagt tgacaaacct aaaaccgtgg aatgggcatc acaaaacatg
     4201 ttggtgctgg gtatcatcgt tatcttaggt ttgggccttc acctctttaa cttctgggct
     4261 aaaatgcagt tacctgaatt ggtgcacaac atgggaggag tagcagacac aacttatgct
     4321 gctgatggtg tttatcacat catgaacact ttctctaacc ctgtatatgt agtgctgtac
     4381 ctcgtttggc tgggcgccct ttggttccac ctgactcatg gtttctggag ctctatgcaa
     4441 tctttgggct ggaacaacaa gatttggatc aaccgctgga aatgcatctc caacatctat
     4501 tcaaccatcg ttgttgtatg ctttgctctg gtagtagtcg tattcttcgt taaatcgttg
     4561 gcatgcggtg cttgctaaat tgtaaattgt aaatgattaa attgtaaata gcattatgac
     4621 taagatagat tcaaaaattc ctgaaggcca gctcgccgaa aaatggagta actataaggc
     4681 tcatcaaaaa cttgttaacc ctgccaacaa acgtcgcctt gacattatcg ttgtaggtac
     4741 cggacttgcc ggagcatctg ctgccgcttc tctgggcgaa atgggtttca gagtattcaa
     4801 tttctgtatt caggattcac cccgccgtgc tcactctatt gcagcacagg gtggtatcaa
     4861 cgcagctaaa aactatcaaa atgatggtga ctcggtttac cgtcttttct acgatacaat
     4921 caaaggcggt gactaccgtg cacgcgaagc caacgtttac cgtctggctg aggtatcaaa
     4981 cgctatcatc gaccaatgcg tagcacaggg tgtacctttc gcacgcgatt acggtggcac
     5041 acttgacaac cgttcattcg gtggtgcaca ggtatcccgt acgttctatg cccgcggcca
     5101 gaccggacag cagctgttgc tgggcgctta ttcagcattg agccgtcagg tacaaaaagg
     5161 tactgttaaa ctttacactc gttacgaaat gctcgacctc gttgtaattg aaggacgtgc
     5221 gcgcggtatc attgcccgta acctcgtaac cggtgaaatc gaacgtttcg ctgctcacgc
     5281 tgtagttatc ggtacaggtg gttacggaaa cgcattcttc ctttctacca acgctatggg
     5341 ttccaacggt tcagttgcca tccagtgcta taagaaaggt gcttattttg ccaatccttg
     5401 tttcgctcag attcacccga cttgtatccc cgtacacggt gacaaacagt ctaagctgac
     5461 attgatgtct gaatcacttc gtaacgacgg tcgcatctgg gttccgaaga agattgaaga
     5521 tgccaaagca ttgcaggcag gcactaaaaa gccgaccgaa attcctgatg aagaccgtga
     5581 cttctatctg gaacgccgtt acccggcatt cggtaacctt gttccgcgtg acgttgcttc
     5641 acgtgcagcc aaagaacgtt gtgatgccgg tttcggtgtg aacaataccg gtttggccgt
     5701 cttcctcgat ttcaaatatg ctatcgatcg tctgggtgag gacgtggttc gtgcccgtta
     5761 tggtaacctc ttcgacatgt acgaagaaat cactgacgag aacccgtaca agactccgat
     5821 gatgatattc cccgctatcc actacaccat gggtggtatc tgggttgatt atgaattgat
     5881 gacttctatc ccgggtctgt tcgctatcgg tgaagccaac ttctccgacc acggtgctaa
     5941 ccgcttgggt gcatctgcat tgatgcaggg tctggctgac ggatacttcg tattgcctta
     6001 cactatccag aactacctgg ccgatcagat tcaggttccg cgcttctcta ccgacctgcc
     6061 ggaatttgct gcagccgaaa aggaagtgaa agataagatc cagaagatca aagccgtaaa
     6121 cggaaaacac tctgttgact ctatccacaa gaaactgggt cacatcatgt gggacttcgt
     6181 aggtatggcc cgtacaaaag aatctctgca gaaagccctg acaggcattg aagaggtgaa
     6241 gaaagatttc tggaccaacg ttcgcatccc gggtgatgta aacgaactga acgtagaact
     6301 ggaaaaagca cttcgtctga tcgacttcat tgaagtaggc atgttgatgg ctcgcgacgg
     6361 tttgaaccgt gaagaatctt gcggtggaca cttccgtacc gaataccaga ccccggaagg
     6421 tgaagcgtta cgtgacgata agaacttctc atacgtagct tgctggaaat acaccggtga
     6481 aaattcagaa ccggagttga tcaaagaaga tttgaactac cagttcgtaa aagttcagac
     6541 tcgtaactac aagtcataat tcggctaatc aattaaagga aaacaaaaat ggataaaaat
     6601 atatcattca cactgaaggt atggcgccag aaaggcccga aagcaaaagg tgcttttgaa
     6661 acatatcaaa tgaaagatat cccgggcgat acgtcgttcc tcgaaatgct ggatatcctg
     6721 aacgaacaga ttattaatga cggtggcgaa cctatcgtat tcgaccatga ctgccgcgaa
     6781 ggtatctgcg gtatgtgttc tctttacatc aacggacacc cgcacggacc tgcgacaggt
     6841 gctactacct gccagatgta tatgcgtcgc ttcaaagatg gagacaccat cacagttgaa
     6901 ccttggcgtt ctgccggttt cccggtaatc cgtgacttga tggttgaccg ttcggcttat
     6961 gacaagatca tgcaggccgg tggttacgta agcgtaaaca caggtgctcc tcaggatgcc
     7021 aacgctatcc ttatctctaa ggatatcgcc gacgaggcta tggatgccgc tgcatgtatc
     7081 ggttgcggtg cttgtgtagc tgcttgtaag aatggttctg ccatgttgtt cgtatcagct
     7141 aaggtcagcc agctgaacct ccttccacaa ggaaaagtag aagcagcacg ccgtgcaaaa
     7201 gctatgcttt ctaagatgga cgaactggga ttcggtaact gtacaaacac acgtgcttgt
     7261 gaagcagagt gtccgaagaa catttcaatc agcaacatcg ctcgtttgaa ccgcgatttc
     7321 atcatcgcaa aactgaaaga ctaagcacaa cttagcattt gattaataag taggaaaatt
     7381 ccccaccggt atcggtgggg aatttttgta tatggagagc agtgttatct cttacggcgc
     7441 ttacgatacc agatgataaa gccggtcaca ggaagtgaag cacccgtcag gctcgcaagg
     7501 aacattataa ttttaccagg aagcccccag atgcgcccgt catgaatctc cagattcata
     7561 cgacggaact tatcggcggg agaggcctcg gtatatttac cggcataagg accggctcct
     7621 ttcaaagaaa ccagtgtata ccggtcaaaa aacaaattat cggtacggta gtaagaccct
     7681 cttttatgta caacactgac ccggtaaaca ccatcggctt gtccgggtaa agcaaaataa
     7741 aaggtcttgg cagcaggttc ttcaaggcgt agctgagtat aaagtctgtc caaagggttt
     7801 gtcacacgat tgacaacctg caatgtatcg gataccggta aaacgtaggg cttcaactct
     7861 tcaccacccg aagtgatgct gtacacgcct ctgctaaacc aattcaggct aaatatcaat
     7921 ccggtaaaac ataatacggc cagcaccaat gcagcataaa aacccgcaac attatgcagg
     7981 tcgaagttaa gccttgaaaa ggtaaagggg cgtttcagag tcaaccgttg cacaagtgcc
     8041 ttgcgtgtcc agcttctggg ccaccaaagt atcactcccg ttatcagggt gatgaggaaa
     8101 atcaatacac tgtaaccaac aatcggactc ccgatctccc tggggagcca taaagtgcga
     8161 tgcccgctaa gcaccaaccg gaagaaatcg aaatcaccgt tatgattcac taccgacttc
     8221 aatacctgtc cgctatacgg attgataaaa acagtactca tccctgcttc cggctgatag
     8281 tagtccaccc aggccgcatc cgatctttca ccgtaagtga tggctgtggc cgaagctcct
     8341 cccatgacag aatccgctat cgcaagtaag cgggaaggcg gcaaaaactc tttctccaat
     8401 ggagctacaa agcgccaagg ttgtgtggca tcggtaattt cgtctttaaa tgcatacatg
     8461 cagccggtga tgcagactat gaataccaca atacccgaaa acaatccaag ccataaatga
     8521 agtttcgcac aagccttccg aaaagtctta ttcatctcct atcaatccag acggaagaaa
     8581 ccgccgacaa acgtggttga aactttagct cccctgaccg cagtagccgc ctgaggatct
     8641 acctgataaa tgtaagtacc ctctgaagta gtgaccggac gataaacata acctccgtct
     8701 accagagcgg caaaacgccg tccgccatct ccgttatgca ccggaatctc tttaatgtca
     8761 cgtaccgttt tattattaag atcgataatg cagcatttca aactcttatc tccccaacgg
     8821 tcggcggatg tctgcggact gatggtgctg acctcggcaa ataccagacc attaccgata
     8881 tatttgatat gggcaggttt caatcctccc gaaaccgtct caaagtcaaa atagtagtca
     8941 tcaaaatgcg tctcaccttt agggatacga aggaaagcag cattcttggt actttgtgag
     9001 aacccgttgg caatggcaga attagacatg atgtacatat cgccggactc taccttaaaa
     9061 ataccgttaa atgcattcca cgaaccggca ggaccggtac gcgtatcttt catcaatgtc
     9121 ttaaactgca tatccggata agagtatacc gcaacaaaag tagtatcggt atataaagtc
     9181 tcaaaagtgg aagggttcat cggaaaataa gtaacgtaca cattaccttc actataacac
     9241 atacccgtga tactcggcca ttcgagttga ttcagcggaa ataccggagc tttgacctga
     9301 gaagtgatag aaacatcact gatatttacg gtatataagg tcatttgatc cccactctcc
     9361 ttattagccg gaagttcaag gccgatcatg ttctgcccgt ccatttgtgt aaacgcattc
     9421 agcgaactgt taaagacaaa gtctccacgc tccgtcagat agccgtttgc atcacgtaca
     9481 attccggttg cactggtcag tcccagtccg ccaatactga acaccgtttg tccggcctgt
     9541 tcataatcac gatatccgtt ttgctcgata cctttggcca ccgcgttgat tgttccggac
     9601 atcaattcgg gtgcagtaac cacataataa gtggtagtcc cattggaatt gatacccagg
     9661 ctgagtacat agggagcaaa aggagtttcc tcatttccca atccttcttc ttcacatgcc
     9721 gtgacaccca ataaaaggca ggcagcaagg agatacatat aaattcgata cattgtaatc
     9781 atcagacttt tttatttact aaagaaatat ctcagtttca cattaaaggc acgcccgggt
     9841 ttctgcaagc ggtagttatc atacagcttt tgattggtca gattggtaca ctccacaacc
     9901 acactatact ttccgttgtc cattgaatac cccaatgcca gatcgtgtga gaactgttcg
     9961 gggattactt ttttagagct ttttgcaccc aagcccggga acgaaagata atacgaatga
    10021 atataattaa gattatagtc aaatgtcagc acagagtttt tccaaatcaa atcgtgaaaa
    10081 cgaacccctg catcggcatt agcaaacaaa taagggatgt tcggcaaacg ctctttatag
    10141 gtaatattct ctgtgatacc ttcgccgaca aagctgtcct tcgtcttctc atatcgctgc
    10201 cggtcggtaa tgtcctgata agtaaaaccg gctcccgtat ggaacagatc tttatagtta
    10261 tatctgacag cagcctcaac accctttgtc aacaccttac ccagattctc gtaaccggta
    10321 gtcgggttac tggtcaggct gacccctttc aggataaagt ctgtcgtata acgataaatg
    10381 aagtttccat cagccgaaag ttgatgggct ccgaaagttt gaatgaagct caaccccaga
    10441 ttcaaattcc ggctgctttc cggttttaaa tccggattcc gctgctgaat caacccgtct
    10501 ccaaacattt cgatactttc cggcaaacga taggcatgct cgtaagagaa cttagcctgc
    10561 aaagagggta agatataata agtagccgcc gcaccgtatc cgaaattggt tttatgatcc
    10621 cgcacttttt cccaacgggc attctctgta tattcatcca accgcttata ggtagaactg
    10681 tacaacttat acatctttcc gaatacattg gcattccaac gatcatagcg gatctgccat
    10741 cccaagcctg tgatattctt agtcagttgc tgaggtacat tgttgttttc atcatccggc
    10801 cgtactttat cattcatggt tctccgcata gcagaaacca cgtggttcag tatcaatgat
    10861 tggtgaccgt cgatcacgta actgatgttt ccgtttccta accattcgcg gttctttatc
    10921 ttggaatccg tataataccc ttctcctgca gaagtagacg gaacggattc tcccaaccag
    10981 ttgtaacggc gggcgatggt atccacattg aaagtattta cagaattata cgttccgtaa
    11041 agtgacagcg aaagtccgtc aagaaacaga tcgtctttct tataacgaat agaagggatc
    11101 acagattcac tcttcatttt tacgccaccg taaacggcat ccatcgtagc accagtctgt
    11161 acatctttat cattcttcga aagaataatg cctgcaagca gatagtcggc ataaggctta
    11221 ttggttattc ccgtctccag gcggatacct cctgaccggt aggcatcatt aaagcgcctt
    11281 acccaccgct cgtctatctt cttattggta gccagatcga tgatgggcac aaacacttta
    11341 taatcattgt cggaatagtt atagaaagca ttggcacgca ccgtgaaacc tgttttcaga
    11401 tgggtatagg ctccattcac cgagacttta tgagtattga aagagccaaa agaataggtc
    11461 gcatccagat aattggcatc tctacggctg acgatattca ccgctcctcc caaggcatcg
    11521 gcacccagat ttacaggtaa taccccttta tatacctcta cacgctcagc catgttagcc
    11581 gagatattag cgaggttaaa agacgatccg aaattatcca tcggtattcc gtccaaaaag
    11641 aatttcacct gattgcccga aaatccgttc aggctgaaat tatagttaga ccccatacca
    11701 ccttcctcac ggatacggac actcgacaca ttgttcaata atttgttgag aggtgcagcg
    11761 ctattatacg ctttcttgat gtcgagtacc gatatggcat acgcctgctc ctgctgccgg
    11821 cgagcttcag attttccaat cacctgtact tcttccagct cttccgcctg ggtatcgatc
    11881 tctatgtccg gaatccggtt cacttttccg gcagtcacat gtatcggcac ctttttagtt
    11941 ttcactccta tgcccgatac aactatcgtc tgactgcccg ccggcacatc attgatatga
    12001 taaactccat tctcgttggt atatccgcca atataaacac cttcaatggc aactgcaacc
    12061 ggatagtaag gttgcttctg ttggtcgacg attcgacctg tcactatacc tttactttgt
    12121 tgttgctgtt cgccggcatg cataagaacg gctgacagca tagaaaaaag acagaataaa
    12181 gctactctgt acaacacttt gtggttcatt aatcactctg tttaattagt ccgcaaaggt
    12241 acgtatatcg acaccggacg acaatcacca tatttaggta ttcaccgaaa ctccgatacc
    12301 taaatacaat gataaaacaa tctctcttcc agaggcctgt ctcattcgga tgaacgcttc
    12361 aatcgaatgc tgcgtggcga ggtaccaaat gactttttac agaagtttga gaaatgcggt
    12421 aaagattcga acccgaattt ataacagatt tcagagatgg tagcctctgt attctgaagt
    12481 tcgtaaatga tctcctcttt gcggcggcta agcatccact catacaccgg ctcatgaaaa
    12541 acattatcga aaatcctcct gaatgtagtc tggctatatc ctccaagttt agcaaactct
    12601 tcaacagtct tcaccttctt atagttctga tatacaaagc actcaaacga agaagcatat
    12661 ttagagagag gatgtaccaa ggaagccagg tcataatccg aataaaaata accgagtatg
    12721 aaagcaagct ctttccgctt taatgataag agatcccgac aaatcttctt ttcgctcaga
    12781 taagtacgtg cagactcaag aaaatgttga agttcgggaa taatgggtaa gggtgaggga
    12841 attaacggag gatcagtctc cttcatgata cgattatacc ggatatcaca aaacaattca
    12901 ggttgattaa actgataata gatacattcc acatcggtca tggccagcat ttctattttc
    12961 gaactgatgg gctgaagcat aaattctccg gctttaagca ttgttccggc atactcccgg
    13021 ctattcacca gcatttctcc cttgataaga aacaaaatga aattctcctc acatttttgt
    13081 gcaggataat ggaaaccacg tctatggtaa acatggaaaa tggcattagg aactgacttt
    13141 ttgcagttct gacacatcat gggatctcca caaacggagc tgggcatata tacgggtgtg
    13201 tttgtttgta tgtttgcgac aaatgtaaga gaattatttg aaaaaacaac taacaataac
    13261 taaaaagtca gtagtacctc cactacaccc tttagaatgg aaatactact gacctttaat
    13321 tagacttgat atatactatt ttgcagattc ttctctagaa tcatcggtcc aaccacctac
    13381 tgtaggagtg aaagatattg catctgcacc tgtcggaaga gttaaagtat accgaatctt
    13441 ctttccttct ccccaagctg tagaattttt aagttctact tttttagttc ctgtaaaagt
    13501 agtttgtcca ttagaagctg taacagtata tgcaacagaa atagcagctg cagatgaatc
    13561 atcaaataac tggggtaata gcataagtgc attatcagct gttgaaaaat caactgtttc
    13621 ttcagaagtt tccttcggat tatatccgct agaattataa gtaacattat aaatataggc
    13681 ctcggaacct ttctgtgatg tccatgtagt gttttcaaaa cccaatgtcc cttcattagc
    13741 gacattctct atctttattt cagttatttt ataagtgaaa ttttgtacta actttactga
    13801 aaagttaatt tgagtaagtg catgtgcaaa tgtcaaagac actccaccgg tattagcttc
    13861 ttttagcaga ttcgtagcct ttgctataac caaatccttt tgagaaccaa cctctttaat
    13921 ggcatatgaa agtgttgggt agccattatc aggggtagta tatacatctg gtgatgatag
    13981 ttcaggagag taagcaaaga aacataactt atcagtagca gatgcaggcc aataataagt
    14041 atccccagcc caagatgtat ttttatcagt tctagtatag ctacttccat tagcaattaa
    14101 tggagttgta aaagccgaag cattagaaac ctctgtttct ccaatattgt atccatacac
    14161 atgaaacgcc gtaaagttat cagtctccaa tggagtgact cttgttgtag tctttacaac
    14221 tgtattgaac ccaatctccg cagttttcgc cgccttctca atctcctcat tctgtgagca
    14281 acctgtgatt gccaatgcag caactgccgc aaataaaatc tttttcataa tagtatgttt
    14341 tataaattaa taattatctc ttttatctgc ctaccggtgt cattccaccg gtatcactat
    14401 atctgtttca tcctcccaat catccacatc cccattcata ccgccattac catccggagg
    14461 agtttccaca tcatctactt ttatttcatc ttctatttca acttcaacca atgccggcgg
    14521 ttttgtttcc tctccttctc ctccttcacc accgccggta ggttcttgta cagcttccgt
    14581 tatattaatc ttaacctcct gtaccgaatt gtccacctta ataatcatca agttcatcat
    14641 caccggaagt tttatttcta aacgggtaat aatagcttcc ggtaatccaa aagtggtaaa
    14701 taccccttct atcttcccgg ctttcacatt caggtcaata ttaatcggat agtcatcgca
    14761 catagcataa gcttttccta aaaaataatg atctgccatc ccaccaatac tccctatcac
    14821 gtttgaaaca ttacttaatc cctgcacttt gatactaaag gagtaagttc ttatcaccaa
    14881 ttttggtttc agcttcagaa tcaatgtctc ttcactattc tgtatatcca aatcatctat
    14941 atttaccaca taaagcggat ccggtcccca aaccatcttt tctgtacctg caatacccaa
    15001 cttacaaaaa ttggtataag cctgaatggt ttcataagat tcctctccac gaattaagac
    15061 cgtttcagta tcgtaattgt aaataacaac agcgtagtgt cccgaaggaa cttttacttc
    15121 cccacctgtt accgacaaat acgtatctat ctttctacct ttttcgtctt tcggatagaa
    15181 aataatccga actccttccg gcaacttctc cgtcactccg ctccaatcca gccgcacttc
    15241 cacaccactc accggataat cgtccagaat atcccgccgg ctgcatcccg tcaccaccag
    15301 aaacgagagg agaaccatgc aaagcaacct tgttatatct ttcattcatt atcatctcct
    15361 tgctgttata agccacacca aagatacttt tgccttggtg gggcctatga agttatagcg
    15421 tgcactactt ttccaaacca agtctccctc ataaggagtg tacttcttgt actccgtagt
    15481 cagataacct atgcccaggc tgaattcaaa cgagagatgc cgtgcaatct gctttgcata
    15541 tccataagtc agccctgaag ctgcataata tcttccttga tagccgtctc ctttaaactg
    15601 gaaatcataa attccccctt cggcataagc tccaatgaaa tgtcccgcca agcgattcct
    15661 ccgcttccgg ttgcccaacc agcaacgacc ttcaacgcct cccgaaagca attgatagca
    15721 aaactcccgg ctactattga gccaccacgg acatttatac tcggcattga ccgaccagcg
    15781 tctgttcaat ggtatttcca cctctatatt cggtgccaat gccaggtcgt atagcaggtt
    15841 gtttttcagt gcaagcactg ttctctgttc tattattact ggtgtttcta tttttccctc
    15901 ttccgggacc accggctgag gatgtacgaa tttcactcgg ggcaatacat tcgccgtact
    15961 caaaaacaca ccggcagctt tatcatccgg tatgggtaca ggtgaatgtt ctctgtatac
    16021 atataaaagc ggtaagattt tattcataat atagcggtat gcttctccac cgttcaacct
    16081 acgtaataaa ttctcacatt tcatccggtc atcgcggtga taatcgatca acatcagcac
    16141 atcctcacga tccggaacgt ggaggtcagc ctgcactctt tcgcgtaaca gcgaccaatc
    16201 cttctggttt acaccaatca tcattctggt ccaggcatcc ggcattgcta ccatggcccg
    16261 gctttctccc gaaagcagaa agagaaaaac aaaaagggtc agtatgcaga tacggttttc
    16321 cataatttgt ctgtttgtgc aatacaaata tagaagttca aatcgataca taataattta
    16381 atcaaagcta aatacaagct ctgaatgctt ctgtgaaacg attgaaagga atttgcaagt
    16441 ttggcggtga agcacccccg cacttgggta gctttccggc caatgccggc ctctaaaagt
    16501 gggtactgcc gttgcttaaa tcttcttact taccacctga cttacttatc ccggcaagaa
    16561 aatagatctg tctctacgac atacgttgtc cgacatgggg gtgtcagacc gtccgacacc
    16621 cccatgttaa acctcccgac atccccatgt cagactatga agagtgggaa cctaatgaag
    16681 aaagcttttc gaggaaagtg aagggaggtt aaaagcaaaa gagttattgc cgatgtttag
    16741 cccacttgta aaagagaaca gtaaaaaaca gtaaaagaaa ctcaaagaga gccaatatta
    16801 agaagaatat ttggataata gataagagaa acctacattt gtacagtgat ttttttcata
    16861 gtattagatt taaggttaac aaaaggttgg agtcaggcgt gactcctttt tttttgcctt
    16921 ttttatctga gtaactggta aactcctcct gccagaaccc gaataacgcc tttcatttca
    16981 agttcaaaca gaatagcact gatcttatta atgggaatat cggcctgaac catcaatgcg
    17041 tttatttgca gatcgcccag ctttccgaga atatcgacaa ttctcagttc ctcggcagac
    17101 agatccggaa agaggtttcg ctgtacggtt tccggcttga cacttttcaa atcgctgtcc
    17161 cagcccattg ctttcacaaa gtccgatgca gactccagca aaacagcttt gttatcctgt
    17221 atcaactggt tgcatccctt tgaatattcg tccgtgaccc gcccgggaaa agcaaaacag
    17281 tcgcgatgat agcttccggc aatatccgct gtaatcagcg aaccgccttt agcggcagac
    17341 tcca
//
