LOCUS       gnlProkkaMAODONAD_144  13881 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MAODONAD_144.
ACCESSION   gnlProkkaMAODONAD_144
VERSION     gnlProkkaMAODONAD_144
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 10:46:05
            Original ID  :: gnl|Prokka|MAODONAD_144
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13881
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13881
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[10540:12970]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10541..12970
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..13881
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13881
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             complement(3..590)
                     /locus_tag="ctg144_1"
                     /transl_table=11
                     /translation="MLIILKQDDSCQVAQTTCTTNSLEIRYKDYSVLKKTLDLNTKSIN
                     SDSCIELIIYGTHGNEKEICKLTKPDIKDLSYFFKGKVCRLVLDACHSACHIPHFKEML
                     TDDGIILCHVGICQVNSIETKTGKDTYERWINGNKEGLKVWSDGIVPAIYTQKNNTLTY
                     YECSKFEVDINHPFTGTEFKTYCLNLKSKGIKM"
     CDS             938..2107
                     /gene_functions="other (smcogs) SMCOG1054:hypothetical
                     protein (Score: 215.9; E-value: 2.1e-65)"
                     /gene_kind="other"
                     /locus_tag="ctg144_2"
                     /transl_table=11
                     /translation="MAVKILSVDDELDLEVLLTQYFRRQIRKGEYEFAFAHNGLEALQK
                     LLETPDFDIILSDINMPEMDGLTLLAKVNELKNPAMKCIMVSAYGDMDNIRSAMNKGAF
                     DFATKPIDLDDLSRTIEKAIEQVRYIRESQQEHNQLESIKNDLAIAGEIQQTILPRSFP
                     PFPELTEVVDIYASMTPAKDVGGDFYDFFQIDDERIGLVIADVSGKGVPASLFMAVSRT
                     LLRATALRGVSSAECLTYANKLLCKESLDSMFVTVFYGIYHYKTGMMDYTNAGHNPPYL
                     LRGGRTVECLPVASNFVVGVFDDIEFESNTLTFGIGDTLLLYTDGVTEAFNDKREQFSE
                     SNLQDILASMHESSSAKEVVTSVLQSVKIFSGDYPQSDDITLLSLQRIK"
     CDS             2126..2431
                     /locus_tag="ctg144_3"
                     /transl_table=11
                     /translation="MEKYEIHFVGSVLDSNTSGDEQAKIVALIEQGHSVALNLSGCSYV
                     SSAGLRVMLYAFKLAKAKSRDVCLVGVSQEVKDVMHMTGFDKFFRFYQTLDELSQP"
     CDS             2446..2874
                     /locus_tag="ctg144_4"
                     /transl_table=11
                     /translation="MTLLQFRPVDGRLDEILSMLMHSREVASHPSLSYAIRLVSEEIIV
                     NILNYAYPQQAEGYLTLCLWDEDGEITLEFIDGGIPFNPLDKADPDISLPLEQREIGGL
                     GIFLVREMMDDVAYTYVNKENRLTIKKKYLQPTDEPVS"
     CDS             2871..4472
                     /locus_tag="ctg144_5"
                     /transl_table=11
                     /translation="MIKLNENIIRWIIAVPCILLTVCLVLYRAYRHSASDRERLALSLE
                     EFRDKEKKSVLIQRVSQQMEEIAYQQKDISEKRRQEAVAQTQKANRMQQQAELARERAL
                     AAQLEAEKAYRMADEQKNLAMERQLQAEQSKRVADTLAFLALGRSLGTLSVTQYRSGNM
                     ELASLLAYTAWWFTKRYDGDVYHPAVFNALSLSCRQDQLWFGHKGAVTGIKLLSGGEEK
                     AKAGRNPLPGLVTVGKYGEMIRWKSENGQTYTSELLLNDPCYDFRDVLLRSDSQMYALS
                     YCGKLISTDSAGIVTRFLPKGEYRQLISIASNLVLAVSTTGIYSFDCINHEIQPCFQPE
                     HSITCVGQMEGYLYVFFKNGTVALLSSDGTFLRFIDSLPENSVVTAFCPLANERYAIGC
                     REGVILICDKNGNIRQKLIGHQAAVTAISRKGNKLFSSSYDCTLRLWDLRKGKTESAVI
                     VTSPGWIHTFCFHPDGTSVFMGDEQGRLYRVPISPDHMAAVVRQGLQRDFTREEWEYYI
                     GKQIPFESYYLKTYQP"
     CDS             4469..7306
                     /locus_tag="ctg144_6"
                     /transl_table=11
                     /translation="MKKIVSLIMCLCSVYANSQEGIPFFVNYPASVYQAHNRNFDVVCD
                     SCGNVYFANFEGILHYDYSRWETIYTPGFSRVTRLFRDSEGRIWVGGYNVFGRIERDGR
                     GCITLRTLLSDLDTNFLGELEDMAEIDKRIYLKATSGGYYTVQSDSILAPVQVLPAQLQ
                     EKWRNQSSVSMNRAFSLPGGETISINSAHGLIMDDSGKKERFSVTERNGLCSNAVSGIA
                     ADGRGNLWGATDNGVFHVFIPSLFSRYTSGEGLKGEVISAVSYKGMIYTGTLQGLYVLK
                     QNTFVPVQGISQACWQLCLSPQGELYAASGDGVYVIRDYNHSEKLTDMAAYSLTFIGHT
                     NLLMGTMDGIYQYSADEERIKKISDVEKVVRLEVKKDRSVWAKTLYGEIYLREEGESSF
                     VLQDRESEEVMTEYTDNDGCHWQTNLKGKEVQVHHSQIDTEKFNQCLYAIRNYVVRVIY
                     IEEDRAAWFGGDFGLIRMDLEKARTFTPVAPRIYLREVCLNRDSVYWGGDLPEESGGAD
                     WQINSTVPRLGNDVRSIRFSFATDAPCFTGSNEYRYRLVGYDPEWSSWDSGTVKEYANL
                     SSGTYTFCVRARDIYGTESEMKQFRFSLLPPFYLQWYCLILYTVAFGMLLFLLFKWRMR
                     SLLKEKERLEALVGQRTKQLVQQKNEIEEKSLKLEKALKELGQAQDELVRQEKMATVGK
                     LTQGLIDRILNPLNYINNFSHLTSGLLKDLYQNLESVKELLDEDTYLDSVDVINMMRDN
                     LEKIEEHGSNTTRVLKAMEEILRDRNRQLEKTELIGLCRKDMELLSSYYQKEITAMHIA
                     VRTSLPDNPLFIDGNAEQLGKTIMSLLNNGMYAIAKKYGKKAYPAEIGLALESKDGQAV
                     IRLYDNGVGIEQSILDKIFDPFFTTKTTGEAAGIGLYLSKEIILNHHGQIAVRSEKDEL
                     TEFTITLPLWEEKSV"
     CDS             7329..8165
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 139.5; E-value: 3.2e-42)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg144_7"
                     /transl_table=11
                     /translation="MEKNISQEKRIEELEARLKEQEKLGSLGLLSAGIAHEIQNPLNFV
                     INFSKLSGQLLADLADRVDEAKARIPEAELEDIKDILSGLRENVDKIKEHGDRAISIIR
                     GILLYSRGKEDEFMPTQIQKLTKEYVWLAYHAMRANYKNFNIAIREDYAKDIPSIRLIP
                     QDFSRAVLNVMNNACYAVWKKWQNAPEGYSPEIMVTLEKLDKRVVLSIRDNGEGMSPEV
                     KRKLFDSFFTTKPVGQGTGLGMAIVRDIIENKHRGKVLFDSVLHEYTCFRFIIPIA"
     CDS             8162..10528
                     /gene_functions="transport (smcogs)
                     SMCOG1082:TonB-dependent siderophore receptor family
                     (Score: 167.9; E-value: 8.3e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg144_8"
                     /transl_table=11
                     /translation="MKRCLLYILCCFGVVQLSAQPADNIRNSFVKAETFYKSGDIDEAC
                     RILEENLSSFQGTMHTEACRLAALCCLALDRFPEAEKYVSLLLKDEPYYYISLQDPERF
                     ADMVRKHRETKVTLVTASQQVETPEEAPVPVTLITEEMIRAIHARCLRDVLIAYVPGIS
                     GLSSNEEMNLAMRGVYSPEQENILIMQDGQRLNSYITNAVSPDYGISLAKVKQIEVLRG
                     PASSLYGSVALTAVINIVTKDGVDVRNGSISVSAGNRGQLAADLLLGKHDMNMDFMAWF
                     SLYRATGESVFVPAEKQYALYPRDGFIRLDNYSGFPAMDGGIKLQRGNLLFSFSMNYAK
                     KRQPYSMWLFSSPYSYERFRTFDGSGPGYSRWSAREQAVYSHTWQRITFSTAFYTDWNK
                     NVHYETSGDTLQDYPIFPNYDYQPIIYPTRGAFQYIRWMDFNVGFNGRVNYAYDWGKLG
                     KGNMLGGVEWNRYTLYDSEYLEGMNFKEIVRTWIEKRLYTGHEMNTDAFLQIKHNLHKN
                     WIVNAGIRYDYKRRSNKRTLQAFSPRLSLIYLRNGLNIKASYSRAFVDAPYYYRNNEMD
                     TYSGGENLQAEYLSSYQVTCAYHHSPSHIDVECNLFYNRASHFLFTQPETRVYENAGSL
                     DMGGVEVVARYKADRLSLDGNLCFQKVLNYTNFFVTDGSVNNVPGFSMNLVANYFLLKK
                     KVQSWSAHLKLNCSSHCYTQVSVLEDGLNGDATNYTVRLPGYAVFSFTTRYKHKRIEGS
                     LGIENLFNNRYECGGATVPIRQKGRWISASILYNF"
     CDS             10541..12970
                     /NRPS_PKS="Domain: AMP-binding (12-401). E-value: 2.4e-83.
                     Score: 271.8. Matches aSDomain:
                     nrpspksdomains_ctg144_9_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (509-568). E-value: 2.7e-10.
                     Score: 32.6. Matches aSDomain:
                     nrpspksdomains_ctg144_9_PP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     259.9; E-value: 6.2e-79)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg144_9"
                     /sec_met_domain="AMP-binding (E-value: 2e-88, bitscore:
                     286.1, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.8e-11, bitscore:
                     32.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNIQENLSRSLSTWGDKPAVVAKDGTVSYQMLERYSANIAQSI
                     RQRLSVTDPSGLRNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAEN
                     ADMVLLLTDSSNEVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPDDCAYIIYTSGTTGNP
                     KGVRISYRNLDTFTRNLIDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLIL
                     AGEDERRDISLLDELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNR
                     LKQQPYRLMNVYGPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGAT
                     GELCLGGPQVSLGYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVK
                     IRGFRIELTEIAERLNRDPDVERAHVVVVERNGRQLLGAYLQPSVSGNFHPEEVKERLR
                     AELPYYMIPNLWQVVDHFQRTINDKIDVRALPAFTSLELKYVPPVHPGEVILCGILKEM
                     LGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPINVSAVYTARNLRRLLLVPRQEP
                     IYWYRQQNLKKPVIILVCGSAYFNHLYFNLADRLYPKYDFLVVDAIYDHFNKVATDIPE
                     LLEYYVRTVQPMIRERTVYALTGFCMGAELAVGLAEMLHRSMGIMPKVFALDGQAWQNP
                     ALCQNYPLLVFPGDTDEMVRERNEIINIYFRTTPNLIYQGEVIVLLSGLFHQQAGLSPE
                     ESWTEENYRIFRTEYDNCERLWNKYYPNAPVLRLPTDHWHFLEGESLEQLITVFLK"
     aSDomain        10577..11743
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg144_9_AMP-binding.1"
                     /evalue="2.40E-83"
                     /label="ctg144_9_AMP-binding.1"
                     /locus_tag="ctg144_9"
                     /protein_end="401"
                     /protein_start="12"
                     /score="271.8"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LSTWGDKPAVVAKDGTVSYQMLERYSANIAQSIRQRLSVTDPSGL
                     RNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAENADMVLLLTDSSN
                     EVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPDDCAYIIYTSGTTGNPKGVRISYRNLDT
                     FTRNLIDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLILAGEDERRDISLL
                     DELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNRLKQQPYRLMNVY
                     GPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGATGELCLGGPQVSL
                     GYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVKIR"
     aSModule        10577..12244
                     /complete
                     /domains="nrpspksdomains_ctg144_9_AMP-binding.1"
                     /domains="nrpspksdomains_ctg144_9_PP-binding.1"
                     /locus_tags="ctg144_9"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       10769..10810
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg144_9_0001"
                     /evalue="3.50E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg144_9"
                     /protein_end="90"
                     /protein_start="76"
                     /score="11.0"
                     /tool="antismash"
                     /translation="LAIFRLGATYLPID"
     CDS_motif       10991..11047
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg144_9_0002"
                     /evalue="1.50E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg144_9"
                     /protein_end="169"
                     /protein_start="150"
                     /score="26.8"
                     /tool="antismash"
                     /translation="AYIIYTSGTTGNPKGVRIS"
     CDS_motif       11549..11635
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg144_9_0003"
                     /evalue="1.20E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg144_9"
                     /protein_end="365"
                     /protein_start="336"
                     /score="27.3"
                     /tool="antismash"
                     /translation="LGATGELCLGGPQVSLGYIGSVQLNEKSF"
     CDS_motif       11708..11770
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg144_9_0004"
                     /evalue="1.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg144_9"
                     /protein_end="410"
                     /protein_start="389"
                     /score="36.2"
                     /tool="antismash"
                     /translation="FIGRKDTQVKIRGFRIELTEI"
     aSDomain        12068..12244
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg144_9_PP-binding.1"
                     /evalue="2.70E-10"
                     /label="ctg144_9_PP-binding.1"
                     /locus_tag="ctg144_9"
                     /protein_end="568"
                     /protein_start="509"
                     /score="32.6"
                     /tool="antismash"
                     /translation="LCGILKEMLGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPI
                     NVSAVYTARNLRRL"
     CDS             12975..13868
                     /locus_tag="ctg144_10"
                     /transl_table=11
                     /translation="MQTENFTLGKKELLILLGLTLVLPFPINWALIELNPLTLMAGADD
                     VPTWIGFGGSYIGGIIGGVISIMILNKTLQQTGVLHHDLKLLQLDTIIYTQQQDWFTGF
                     KQELAENLKSIDLYVLNTVVSSISMKNYAYAKEVLTEINKGLEYQMVAASFSFTSTHLS
                     SEEKKYMNLVRRVQTEYSSFIKDILYYIPLAETISSRKKLNYDQLMDYTLSQYDYLQGQ
                     EGESTASGAIIPRVMEIDPSDDIRKELERIMEERLTGRTYLYHLKSDLAEATHQLIIYE
                     ENRINSILHKPEREMN"
ORIGIN
        1 accattttaa ttccttttga ttttaaattc agacaataag tcttaaattc agttccggta
       61 aaagggtgat taatatctac ttcgaatttg ctacattcgt agtaagttaa agtgttattc
      121 ttttgagtat agatagctgg aacgattcca tccgaccata cttttaatcc ttccttattg
      181 ccatttatcc accgttcata ggtgtcttta cctgttttag tttcgatgct gtttacttgg
      241 cagataccta catgacataa tatgattcca tcatctgtta acatctcttt gaaatgtgga
      301 atatggcagg cgctatggca agcatcaaga actaatctac aaacttttcc tttgaagaaa
      361 tagctcagat cttttatgtc tggtttggtt agtttgcaaa tttccttttc atttccgtgt
      421 gttccgtaaa taattaactc tatacagcta tcgctattaa tagattttgt gttcaaatcc
      481 agagtttttt tcagtacact ataatctttg tatcggattt ctaaagagtt tgttgtacat
      541 gtcgtttgtg caacttgaca actatcatct tgttttaaaa taataagcat aatagtgatt
      601 tgtaaaaagt tcctactctt tcttcggctt ttcggaatcc gccgtttcta tttattcttt
      661 gtaagcttac ggtgacaaaa gtgagaagaa aagttccatc ttaaaaatat aaattctgaa
      721 tacggaatag tttctttcag gagtgtaaat caatctttca agtgctgtct tctaagccac
      781 gaaagcaata tacctgtatg cttataagac aatatcgtcc attcggaaaa acattcttcc
      841 tgtttaaaat ataaaattgt aaccgggtcg atcactctct atttttgcca tcataaacgt
      901 cagaacaaac ggttgaaatt cataaataac aatagatatg gcagtaaaaa tattgagtgt
      961 agatgatgaa ctcgatttag aagtattact tacccagtac ttcaggcgac aaatacgaaa
     1021 aggtgaatac gagttcgctt ttgcccataa cgggttggaa gctttacaga aacttctgga
     1081 aactcccgat ttcgatatca tcctgagtga tattaatatg ccggagatgg atgggttgac
     1141 cctattggct aaggtcaatg aactgaaaaa tccggcaatg aagtgtataa tggtctctgc
     1201 ttatggagac atggataaca tacgttctgc tatgaacaag ggagcgtttg attttgcaac
     1261 caaaccgatc gatttggatg atctgtcgcg gactattgaa aaggcgatcg aacaggttcg
     1321 ctatatccgt gagtcacagc aggagcacaa ccaactggaa tctatcaaaa atgacctggc
     1381 cattgcggga gaaatccagc aaacgattct tccccgttcc tttcctcctt ttccggaact
     1441 gacggaagtg gttgatattt atgcttccat gactccggca aaagatgtag gtggcgattt
     1501 ttatgatttc ttccagattg acgatgaacg tatcgggctg gtgattgctg acgtatccgg
     1561 gaaaggggtg ccggcatcct tgttcatggc ggttagtcgg accctgctcc gtgcaactgc
     1621 tcttcggggt gtttcgtcgg cagaatgcct tacttatgcc aataagttac tgtgtaaaga
     1681 gagcctggac tctatgtttg ttacggtctt ttatgggatt tatcattata aaaccggcat
     1741 gatggactat accaatgccg ggcataatcc cccttatctc cttcgcggcg gacggactgt
     1801 tgaatgcttg cctgtcgctt ctaattttgt ggtaggcgtg ttcgatgata ttgaatttga
     1861 gagtaataca ttgacgttcg gcatcggtga cactttactt ctgtatacgg atggtgtcac
     1921 agaggctttt aacgacaagc gggaacaatt ctcggaaagt aacttacagg atatattggc
     1981 gtctatgcac gaaagtagtt ccgcaaaaga ggttgttacg agtgtattgc agtctgttaa
     2041 gattttctcc ggagactatc ctcagtccga tgacataacc ctgctttctc ttcaacgaat
     2101 caaataatat taaaataaaa gaacgatgga aaagtatgaa attcattttg taggttccgt
     2161 cttggattca aatacaagcg gtgacgaaca agcaaaaatt gtagctctta tcgagcaagg
     2221 acattctgtt gcattaaatc tcagcggctg ttcttatgta tccagtgccg gattgagagt
     2281 catgctttat gcctttaagc tggcgaaagc taaaagtaga gatgtttgcc ttgtcggtgt
     2341 gtcacaagag gttaaagacg tgatgcacat gaccggattc gataaattct ttcgttttta
     2401 tcagactctc gatgaattat cacaacccta aaaattacct gagcaatgac gttacttcag
     2461 tttcgccctg tcgatgggag gttagatgaa attcttagta tgctgatgca tagtcgtgaa
     2521 gttgcttcac atccttccct gtcttatgcc atccgtttgg taagtgaaga gatcattgtc
     2581 aatattctca attacgctta tccgcagcag gcagaaggtt atctgactct gtgcttatgg
     2641 gatgaagacg gagagattac tttggagttt atagatggtg gtattccatt caatcctttg
     2701 gataaagccg atcctgatat ttcattaccg ttagaacaac gtgaaatagg aggattgggc
     2761 attttcctgg tacgtgaaat gatggatgac gtagcgtata cgtacgtgaa taaggagaat
     2821 cggttgacca ttaaaaagaa atatctgcaa cccactgatg aacctgtatc atgatcaagt
     2881 taaacgaaaa tataatccgt tggatcattg ccgttccttg tatacttttg acagtatgtc
     2941 tggtcctata ccgggcatat cgtcattcgg catcggacag ggagcgtctt gctctgtctc
     3001 tggaggaatt ccgggataaa gaaaagaaat cggttcttat acaacgggtc agtcaacaaa
     3061 tggaggagat tgcttatcaa caaaaggata tttccgaaaa gagaagacag gaagccgttg
     3121 cgcaaactca aaaggccaac cgaatgcaac agcaggcaga gttggcacgg gaaagagcgc
     3181 ttgctgcaca attggaggct gagaaagcgt atcggatggc agatgaacaa aagaatctgg
     3241 cgatggaacg gcaactacag gccgaacagt cgaagagggt tgccgataca ttggcttttc
     3301 tggctttggg acgttcattg gggacactct ctgttactca atatcggtcg ggcaacatgg
     3361 aattagcttc tctgttggca tataccgcct ggtggtttac caagcgatat gatggcgatg
     3421 tatatcatcc ggctgttttc aatgcattgt ctttgtcttg caggcaagat cagctttggt
     3481 tcgggcataa aggagctgtt actgggatca aactgttatc cggaggcgag gaaaaagcaa
     3541 aagccggtcg gaatcctctg ccgggattgg tcactgtcgg caagtacggt gagatgatac
     3601 gttggaaatc ggaaaatggg cagacctata cctccgaatt actgttgaat gatccctgtt
     3661 atgattttcg ggatgtgttg ctgcggtccg attcacagat gtatgccttg tcatactgcg
     3721 ggaagcttat ctccacggat tccgccggta tcgttacccg ctttttgcct aaaggagaat
     3781 atcggcaatt gatttcgatt gcctctaact tggtattggc ggtttccaca accggtattt
     3841 attcttttga ctgtatcaac catgagatac aaccttgttt tcaaccggaa cattcgataa
     3901 cttgtgtcgg tcaaatggaa ggctatctct atgttttttt taagaatggg acagtagctt
     3961 tactttcgtc ggatggtaca tttctcagat ttatagacag cttgcccgag aatagtgtgg
     4021 ttactgcatt ctgtcctctt gccaatgaaa gatatgccat tggctgtcgt gaaggagtta
     4081 tcctgatttg tgataagaat ggaaatatcc ggcagaagtt gatagggcat caggctgcgg
     4141 ttactgctat ttcccggaaa gggaacaaac tgttttcgag tagttacgat tgtacgttgc
     4201 gtctgtggga tcttcgtaaa ggaaagaccg agtcggctgt tattgtgaca agccccggtt
     4261 ggattcatac tttttgcttt catccggacg gtacatctgt ctttatggga gacgaacagg
     4321 ggcggttgta tcgggtacct atttcacccg atcacatggc tgctgttgtc cgtcaggggt
     4381 tacagcgtga ttttactcga gaagaatggg agtattatat cggtaagcaa attccatttg
     4441 aatcctatta cctaaaaacg tatcagccat gaaaaagata gtctctttga taatgtgtct
     4501 ttgctcggta tatgcaaatt cacaagaagg tatcccgttt tttgtaaact atccggcttc
     4561 ggtttatcag gcgcacaatc gtaatttcga tgtcgtttgc gacagttgtg gaaatgtcta
     4621 ttttgctaat ttcgaaggta tccttcatta tgactatagc cgttgggaaa ctatttatac
     4681 accgggcttt tcccgtgtca cccgtttgtt tcgtgattcg gaaggtagga tatgggtggg
     4741 aggatataac gtgttcggac ggatagagcg tgatggacgc ggatgtatta cgttgagaac
     4801 ccttctttcc gatctggaca caaacttttt gggcgaattg gaagatatgg cagaaataga
     4861 taaacgcatt tatctgaaag ctacatcagg aggatattat acggttcagt cagattccat
     4921 tttggcaccg gttcaggtac ttccggccca attgcaggaa aagtggagaa atcaatcctc
     4981 agtctcaatg aatcgggcgt tttctctacc cggaggagaa acaatctcga taaactctgc
     5041 ccatggatta ataatggatg acagtgggaa aaaagaacgg ttttccgtaa ctgagagaaa
     5101 tggcttatgc agtaacgctg tttcgggtat tgcggccgat gggcgtggca atctctgggg
     5161 agctacggat aacggtgtgt ttcatgtttt tattccctct ttgttcagcc gttatacctc
     5221 tggtgaaggt ctgaagggag aggtaatatc ggctgtctct tacaaaggaa tgatatatac
     5281 cgggacctta cagggattat acgtattgaa gcaaaacact tttgttcctg ttcagggaat
     5341 ttcgcaagca tgttggcaac tgtgtctttc tccacaagga gaattatatg cagcgtccgg
     5401 cgatggtgtg tatgtgatcc gggattataa tcattcggaa aaactcacag atatggcagc
     5461 ttattcattg acattcattg ggcatacgaa ccttctgatg ggcactatgg atgggattta
     5521 tcaatattcg gcagatgagg aacggataaa gaaaatttcc gatgtcgaaa aagtcgttcg
     5581 tctggaagtg aagaaagatc gttctgtatg ggctaaaacg ttgtacggag aaatctattt
     5641 gcgggaagag ggcgaaagct cttttgtact tcaagacaga gagagtgaag aagtaatgac
     5701 cgagtatacg gacaacgatg gctgtcattg gcagacaaat ctgaaaggaa aagaggtaca
     5761 ggtacatcat tcgcaaattg atacggagaa attcaaccaa tgcctgtatg ccattcggaa
     5821 ttatgtcgtg agggtgattt atattgaaga agacagggcg gcatggttcg gcggtgattt
     5881 tggtttaatt cggatggacc ttgaaaaggc ccggacattt actccggttg ctccccgcat
     5941 ctatcttcgt gaagtttgtc tgaaccgtga ttctgtctat tggggaggag atttgccgga
     6001 agagtccggg ggagcggact ggcagataaa tagtacagta cctcgtttgg ggaatgatgt
     6061 acgttccatt cgtttttcat ttgctaccga tgcgccctgt ttcaccggtt ccaatgagta
     6121 tagatatcgc ctggtcggtt atgatccgga atggagttcg tgggattccg ggactgtgaa
     6181 agagtatgcc aacctttcgt cgggtacgta tacgttttgt gtccgggccc gtgatattta
     6241 cggcacagag agtgaaatga aacaattccg cttttcgtta ttgcctcctt tttatttgca
     6301 atggtattgt ctgatcctat ataccgttgc ttttggaatg ctgttgttct tattgtttaa
     6361 atggagaatg cgcagtttgc tgaaagagaa ggagaggtta gaggcccttg tcggccaacg
     6421 taccaaacag ttggtacaac aaaaaaatga aattgaggaa aagtccttaa aattggaaaa
     6481 agcattgaag gagctgggcc aggcacaaga tgaattggtt cgacaagaaa aaatggctac
     6541 tgtaggtaaa ctgactcaag ggttgattga ccgtattctg aatccgttga attacattaa
     6601 taatttttcc cacctgacct caggattact gaaggaccta tatcagaatc tggagagtgt
     6661 aaaagaactt ttggatgaag atacctactt ggattcggtg gatgtcatca acatgatgag
     6721 agataatctg gaaaagattg aggaacatgg aagtaacacc actcgtgtac tgaaggccat
     6781 ggaagaaatc ctgagagacc gtaacaggca actggaaaaa acagaattaa tcggtttatg
     6841 ccggaaagac atggagctat tgagcagtta ttatcagaag gagattacgg ctatgcacat
     6901 tgcggttcgt acttccttgc ccgataatcc gttgtttatt gacgggaatg ccgaacaact
     6961 gggaaaaacc attatgagtc ttcttaacaa tggtatgtat gccatagcca aaaaatacgg
     7021 taagaaagcc tatccggcag agattggcct ggcattggaa agtaaggacg gacaggcagt
     7081 cattcgccta tatgacaatg gagtggggat cgagcagagt attctggata aaatcttcga
     7141 tccgttcttt actaccaaaa caaccggaga ggcagcaggt atcggtttgt atctgagtaa
     7201 ggaaatcata ttaaatcacc atgggcagat agcagtacgt tctgaaaaag atgaattgac
     7261 agaattcact atcactctgc cattgtggga ggaaaagtca gtataaataa acatagaaca
     7321 gattgattat ggaaaaaaac atttcacaag agaaacgaat tgaagagttg gaagcacggc
     7381 tcaaagagca ggaaaagctg ggatcattgg gcttgttgag tgcaggcatt gcacacgaga
     7441 tacagaatcc tttgaatttt gtcatcaatt tcagtaaact gtccggtcaa ttgttggccg
     7501 acctggccga tagggtggat gaagcaaaag ctcgtattcc ggaagcggaa ctggaagata
     7561 tcaaagatat actttccggg ctgagagaga atgtggacaa aatcaaagag catggtgatc
     7621 gggctatcag cattatccgt ggtattttgc tttactccag ggggaaagaa gacgaattca
     7681 tgcctacaca aatacaaaaa ttgactaagg aatatgtgtg gctggcttat catgccatgc
     7741 gggccaatta taagaatttc aatattgcta tccgtgaaga ttatgctaaa gatatcccct
     7801 cgatccggct gatcccgcag gatttcagtc gggcagtctt gaatgtgatg aataatgcct
     7861 gctatgcagt atggaaaaaa tggcagaatg ctcccgaagg atattccccc gagataatgg
     7921 tgaccttaga aaagttggat aaaagagttg tactttctat tcgtgataac ggagagggca
     7981 tgagtccgga ggtcaaacga aaactatttg actctttttt cacaacaaaa ccggtggggc
     8041 aggggacagg ccttggtatg gcaatcgttc gtgatattat agaaaacaaa caccgtggaa
     8101 aagtattgtt tgattcggtc ctgcatgaat atacttgttt ccggtttatc attcctatcg
     8161 catgaaacgc tgtctgctat atatcctttg ctgctttggg gttgtgcaac tgtcagctca
     8221 gccggcggat aacatccgta attcgtttgt aaaggcggaa acattttata agagcggaga
     8281 tatcgatgaa gcttgtcgta tcttggagga gaatctgtcg tcttttcaag gtacgatgca
     8341 taccgaggcg tgccgtttgg ctgcattatg ctgtttagct ttagaccgct tcccggaagc
     8401 ggaaaagtat gtttcgctgt tattgaaaga cgaaccttat tattatatct cgcttcaaga
     8461 tccggaacgc tttgcggata tggtaaggaa acacagggag actaaagtaa ctctggtcac
     8521 agcctcacaa caggtagaga ccccggaaga agctccggtg cctgttactt taattacgga
     8581 ggagatgata cgggctatcc atgcccggtg cctgcgggat gtactgatag cttatgtgcc
     8641 cggtatatcc ggtttgtctt ccaatgaaga gatgaatctg gctatgcgcg gggtatattc
     8701 tcccgaacag gagaacatat tgattatgca ggatggacaa cgtctgaaca gttatattac
     8761 taatgctgtt tcgccggatt atggtattag tctggcaaaa gtcaaacaaa tagaggtgct
     8821 gcgcggaccg gcttcttcgc tttatggcag tgtggctttg acagccgtga ttaatatagt
     8881 tactaaagac ggggtggatg ttcgtaatgg ttccatatct gtcagtgccg gtaatcgggg
     8941 ccagttggct gctgacctgc tattgggaaa gcacgacatg aacatggact ttatggcatg
     9001 gttctccttg taccgtgcaa cgggagaatc ggtttttgtc ccggccgaaa aacaatatgc
     9061 tctttacccc agggacggat tcatccgtct ggacaattat tcgggatttc ctgccatgga
     9121 tggaggaatt aaattgcaac gtggaaattt gctttttagt ttcagtatga attacgcgaa
     9181 gaaaaggcaa ccttatagca tgtggctctt ttcttctcca tattcttatg agcggtttcg
     9241 tacttttgac ggttccggcc cgggatattc cagatggtcg gcaagagaac aggctgttta
     9301 tagccacacg tggcagcgga tcactttcag taccgcattt tataccgatt ggaataaaaa
     9361 cgtacattat gaaacctcgg gagatacttt acaagactat cctatttttc ctaactatga
     9421 ttatcaacct attatttatc cgactcgcgg agcatttcaa tacatccgct ggatggattt
     9481 taacgtaggc tttaatgggc gtgtaaacta tgcctatgat tgggggaagc tggggaaagg
     9541 caatatgctt ggcggtgtgg aatggaatcg gtatacgctt tatgattccg agtatttgga
     9601 aggtatgaat tttaaagaga tcgtcaggac gtggatcgaa aaacgacttt acacgggaca
     9661 cgagatgaac acggatgcct ttctccagat taaacacaac ctgcataaaa attggattgt
     9721 caatgccggc atcaggtatg actataaacg gcgaagtaat aagcggacat tacaggcttt
     9781 ttctccccgt ctgtcactaa tttatctcag gaacggatta aatatcaaag ccagttattc
     9841 cagagcattt gtcgatgcgc cctattatta cagaaacaat gaaatggata cctattcggg
     9901 tggcgaaaat ctgcaagctg aatatctaag ttcatatcag gtgacttgtg cttatcatca
     9961 ttcaccttca catatagatg tagagtgtaa tttattttat aatcgggcgt cccatttcct
    10021 gttcacacag ccggaaacac gtgtttatga aaatgccggt tctctggata tgggaggtgt
    10081 cgaggttgtt gcccgttata aggcagaccg actaagcctg gatggaaacc tgtgttttca
    10141 gaaagtattg aattatacca atttttttgt taccgatgga tctgtgaata acgtacccgg
    10201 cttttctatg aatcttgtag caaactactt tttacttaaa aagaaagtac agagctggtc
    10261 tgcccattta aaattgaatt gcagtagcca ctgctacact caggtaagtg tattggaaga
    10321 tggactcaat ggagatgcga cgaattacac agtccgtttg cccggttatg ctgtcttttc
    10381 tttcactacc agatataagc ataaaaggat agaaggcagt ctgggcattg agaatctttt
    10441 caataaccga tatgaatgcg gaggagcgac tgttcctatc cgccagaaag gaaggtggat
    10501 ttccgccagt atattgtata atttctaaat caaactaata atgaaaacaa acattcaaga
    10561 aaatctttct cgatcactct ctacctgggg tgacaaaccg gcggtcgttg caaaagacgg
    10621 taccgtctct tatcaaatgc tggaacgtta ctctgccaat atagcacaat ctatccgtca
    10681 acgtttatcg gtaactgatc cgtccggact tcggaatatc tgtatcggag tttgtatgga
    10741 acgaaacaaa actttagtac ctgccattct ggctattttc cggttagggg caacttattt
    10801 accgatagat ccctcgctgc cggataatcg taaacggtat atggctgaaa atgcggatat
    10861 ggttttgttg ttgaccgatt catcgaatga agtaggtgga attccgtccg tccgccaact
    10921 ttacctgaat ggggagcaac tatccgaacc ggttgttggt gactatactg aagttcttcc
    10981 cgatgattgc gcctatatta tatatacttc cggaacaaca ggcaatccca aaggtgtacg
    11041 tattagttat cggaatctgg atacatttac gaggaatctg atagataaga aattgtatca
    11101 tttgtctgat ccggcaaaca ggtatctggc gtttgcgagt atcagttttg atgcttccat
    11161 attagaactg atgatgtgta ttccggtcgg aggaacattg atcctggccg gtgaggacga
    11221 acgcagagat atttctttac tagacgaact gatcaggcgc gagaaggtga atattgcttt
    11281 ttttcctcct tcgttgctgg gcatgtttgc cgaccttgac tttccatcct ttaagactct
    11341 gctctttggt gcggaggcta ttggtgaaaa gttatttaac aggctgaaac agcagcctta
    11401 ccggttgatg aatgtatatg gaccgacaga gaataccgta ctcagtacca tacggattgt
    11461 aggcaaagat acgtcgtatg acgatattgg ctatccgctc aagggaactg tctgttatgt
    11521 tttgtctgaa aacctccaac agacaactct tggggctaca ggagaacttt gcttgggagg
    11581 acctcaggtt tcgctgggat atattgggag tgttcagctg aatgaaaaat cattcatctc
    11641 gtacgatgga gaacggttgt acaggacagg tgacctggta cagcagcaac cggacggttc
    11701 gatacggttt atcgggcgaa aagatactca ggtcaagata cgtggttttc gtatcgaatt
    11761 gactgaaata gcagaacgat tgaatagaga tccggacgtg gagagagccc acgtagtagt
    11821 tgttgagcgg aatgggcgtc aattattggg agcttatttg caaccctcag tctccggtaa
    11881 ctttcatccg gaagaggtca aagagcgttt gcgtgcagaa cttccttact acatgatacc
    11941 caatttatgg caggtggtag atcattttca gcgtactata aatgataaga ttgatgtccg
    12001 ggcgctcccg gcttttactt cattggagtt gaagtatgtt cctcctgttc atccggggga
    12061 ggttatctta tgtggaattt tgaaggaaat gttaggtttg cctcaagtca gtgttgaggc
    12121 cgatttgatt gatgatctgg gattaacttc gctggatatg ttgaggcttg ttaccgaggc
    12181 caataaaaaa ggatgtccca tcaacgtatc tgcagtttat actgcccgta atctgcgccg
    12241 attattgctc gttccgcggc aagaacctat ctattggtac aggcagcaaa acctgaagaa
    12301 acccgtaatc attctggttt gtggatctgc ctattttaat catttgtact ttaatttggc
    12361 cgaccgcctt tatcccaaat atgactttct agttgtagat gctatctacg atcattttaa
    12421 taaagtggct acggatattc cggaactgtt ggaatattat gtccggacgg ttcagccaat
    12481 gatccgggag cgtaccgtct atgcgcttac cggcttttgt atgggagctg aactggctgt
    12541 cggcctggcc gaaatgttac atcgctccat ggggataatg ccaaaagttt ttgctctgga
    12601 tggacaggct tggcaaaatc cggctctctg tcaaaattat cctttgttgg tatttcccgg
    12661 agatacagat gaaatggtac gtgaacggaa cgaaatcata aatatttatt ttcgaaccac
    12721 tcctaatctg atttatcagg gagaggttat tgttttgctg tccggattgt tccatcaaca
    12781 ggcgggattg tctcctgaag agtcgtggac ggaggaaaac tatcgtatat tccggacaga
    12841 atatgacaat tgcgaaagat tatggaataa atattatccg aacgctcctg ttttgcgatt
    12901 gccgacagat cattggcact ttttagaagg ggaatcattg gaacaattaa taactgtgtt
    12961 tttgaagtag atttatgcag actgaaaact tcactttagg taagaaagag cttcttattt
    13021 tgcttggctt gactcttgta ctgccttttc caatcaattg ggcattaatc gaactgaatc
    13081 cgttgactct gatggcgggt gcagacgatg tgcccacctg gattggtttc ggcggcagtt
    13141 atattggagg aatcatcgga ggggtcatct cgattatgat tctgaacaag acacttcagc
    13201 agacaggtgt acttcatcac gatttgaaac tcctgcagtt agataccata atttatactc
    13261 agcaacaaga ttggtttacc ggtttcaaac aagaactggc agagaatctc aaatctattg
    13321 atttgtatgt gttgaatacg gttgtttcgt ctatatccat gaaaaactat gcatatgcca
    13381 aagaggtgtt gacagaaatc aataaagggc tcgaatatca gatggttgcc gcatcctttt
    13441 ctttcacttc tacgcattta tcatccgaag aaaaaaagta tatgaatctg gtacgccgcg
    13501 tacagactga atatagctct tttatcaagg atattcttta ctatattcct ttggcagaaa
    13561 cgatatcttc caggaaaaaa ctaaactatg atcagctgat ggactatact ttgtcccaat
    13621 atgattattt gcaaggtcag gaaggggagt ctacagcttc gggagccatc ataccgcgtg
    13681 ttatggaaat cgatccatct gatgatatac ggaaagaact agaacggata atggaagaaa
    13741 gattaaccgg gcgtacctat ttgtatcacc tgaagtcaga tcttgcagag gctacgcatc
    13801 aattaattat ttatgaagag aaccgtataa actctattct gcataaacct gagagagaaa
    13861 tgaattgaca tatattaata t
//
