LOCUS       c00294_gnlPro..        15027 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MAODONAD_294.
ACCESSION   c00294_gnlPro..
VERSION     c00294_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 08:44:42
            Original ID  :: gnl|Prokka|MAODONAD_294
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15027
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15027
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[388:5027]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      389..5027
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15027
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15027
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             389..793
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg294_1"
                     /sec_met_domain="Glyoxalase_4 (E-value: 4.5e-24, bitscore:
                     75.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGDTKIELLEPTCPESTIAKFIENKGAGVHHVAFAIEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             919..2472
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg294_2"
                     /sec_met_domain="CT_Btheta (E-value: 4.3e-291, bitscore:
                     955.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIELRAQARLGGGEKAIEKQHAKGKYTARERIAQL
                     LDEGSFEELDMFVQHRCTNFGQEKKHFLGDGVVTGYGTIEGRLVYVFAQDFTVFGGSLS
                     ETMAQKICKVMDMAMKMGAPVIGINDSGGARIQEGINALSGYAEIFQRNIMASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMTEGTSYMFLTGPAVVKTVTGEDVSQEDLGGASVHAS
                     KSGVTHFTAETGEEGLAIIRKLLSFIPQNNLEEAPLVNCTDPIDRMDDLLNEIIPDSPN
                     KPYDMYEVIGAIIDNGEFLEVQKDYAKNLIIGFARMNGQSVGVVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTV
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVAVLYAKEAKDQENPAQFLA
                     DKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             2493..3407
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg294_3"
                     /sec_met_domain="OAD_gamma (E-value: 2.6e-16, bitscore:
                     50.6, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKRIGIFIALLAMVCMGLRAQSATSLRINEVLVVNDQNYQDDY
                     GLHNAWIEIFNTSFASVNLEGCFLTNDKNNPTKYPIPKGDVLTLIKPRQHALFWADGMP
                     NRGTFHVNFTLDPNKENYIALYDSNGKTLIDEVTIPAGQLADRSYAREKDGSANWVVKG
                     EGEHSYVTPSTNNMTIDKNPKIENFKKHDSIGIGMAIIAMSVVFIGLVLLYLSFKAVGN
                     VAVRLGKKNAMKATGITDKTEAKEKNLGSHTGEETAAIAMALHEYLNDAHDVEDMILTI
                     NKVKRTYSPWSSKIYTLRQTPKR"
     CDS             3433..3864
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 69.7; E-value:
                     4.8e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg294_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.6e-22, bitscore:
                     69.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQYKYKINGNLYNVTVNDVEDNIANVEVNGTSYKVELDKPVKAA
                     PKPVTRPAAAPKTETGAPVVTKQPTASKKDGVKSPLPGVILDIKVKEGDTVKRGQTIII
                     LEAMKMENNINANKDGKVAEIKVNKGDSVLEGTDLVIIE"
     CDS             3867..5027
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg294_5"
                     /sec_met_domain="OAD_beta (E-value: 8.3e-154, bitscore:
                     502.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFVSFLGNNLVDFWGYTGFANATPGHLFMLLIGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYIIALLIGFEPNQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRALTTKHERLIRMKPPRIVSHTEKVIFP
                     IVGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDVITILLGLTVGAS
                     TQASQFLTWDSILIFILGAFSFIIATASGVMFVKFFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             5176..6507
                     /locus_tag="ctg294_6"
                     /transl_table=11
                     /translation="MRTRTMKPLFLIFCLCLSPLLMGQNQNKIQEAMANYDYETAVELI
                     NKEPPTIPLLMQKAKALKGIGSNAEALRSIRQVIAEDSTNQQAHIEAAECCKAMAKYND
                     ALDYYRKAISLNPKNKYARLQFINLLCNTKNYAEAFGESSMMSETDSSAVVLHLQAQSL
                     EGMQQILPAIGCYEVIQDKYPDDYLAAAKLGNLNIVAGYPEYAIQATERYRERDSTNLI
                     VNQQNALAYCHAEQYPTAIKRYEKLCQQGDSSTQTLYYLGVSYYADEYYYEAHACFSKL
                     QKEMEENPNLLYYLGRCCAKTSWKKEGIEHLEKAIELTIPKDSTMIRLYKGLVDCCKLA
                     QDTPKQIQALRELYKYDKTNHKLLYDIAWNYSYQLKDNKSAERYLQAFLKTRKANARKE
                     EPVSEKGELVLGLENYYNAAENWLKDLQKEKFFKEGIPLESQKQ"
     CDS             6523..7815
                     /locus_tag="ctg294_7"
                     /transl_table=11
                     /translation="MKHWILLLYLGFSVVLQAQNTASVQEAMANYDYKTVIRLIDEESA
                     SPQLLIQKAKALKSLGRTAEALSTLQHIIIELPENQQALVEAAECCRQLSKFNEALGYY
                     RKVMELNPEHIYAHLQYTRLLYNYQRYGDALRESIALARKDSSATVLRLMAESMEGAGM
                     PVESMFCYLSIIRKYPSDYLSVAKLGSIFNTMKDYEGAIALTEAYRRTDSTNVEVNRQN
                     ALAYCLRKEYPTAIKRYQDLTARGDSTLLTCYYLGVSYYATKEYYKARDWLLKAKSCQS
                     PGANLLYYLGRSCSKTLWKQEGIGYLNQAIALTIPADSIMERLYSGLADCYRQTKQTRD
                     QIKATKEQYKYAPDKHILLYNLAFLSDKIGDTKATEHYLQAFLRTKSKQNAVLQQPDDD
                     EEEPAPYIDYYKSATNKLESIRKEKFLKGEK"
     CDS             8319..10169
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg294_8"
                     /sec_met_domain="Alpha-amylase (E-value: 1.1e-63, bitscore:
                     206.2, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLLLLLGSFLLSLTTYAAMNISKIDPPFWFTGMNNPELQLMVY
                     GEGIGQASVSVNYPGVSLSSVVKLESNNYLLVYLHLDKEVKPGKMPITFTVGKKKLVKE
                     YELKARSKAGVDHKGFDASDALYLLMPDRFANGNPDNDRIEGMAEYKVDRNDPNARHGG
                     DLAGIEQNLDYFTDLGVTALWFTPVLENNMKGGSYHGYATTDYYKVDPRFGTNEEYRSL
                     IAKAHNRGIKVVMDMIFNHCGVEHPWIKDMPSKDWFNHADFKNNFVQTSYKLTPHVDPY
                     ASEYDFDQMNNGWFVEAMPDLNQKNPHVYKYLLQNSLWWIEYADIDGIRMDTYPYADYD
                     AMSNWMKELNEEYPNYNTVGETWVTEPAYTAWWQKDSKLSAPRNSHLKTVMDFSFFDKV
                     NTAKNEQTDTWFKGLDRVYNNFVYDYLYPNPASVLAFIENHDTDRFLGEGENLDMLKQA
                     STLLLTTRRIPQLYYGTEVMMNGVKSKSDGYVRKDFPGGWTDDKENALTPEGRTRLQNE
                     SYNFYRNLLNWRKGNDVIAKGSMKQFMVQHGVYAYARQYKGKTVFVLLNGTDKEVKLPL
                     KYYAEVLKDKTQGKDVISGKVTALNEELTMAPRQSMVIEL"
     CDS             10327..10767
                     /locus_tag="ctg294_9"
                     /transl_table=11
                     /translation="MTNNESERELVLQTLRTWMAFRQAVQRVLKRHNVDMTFEMLQVMN
                     CLWNKQGISQQSLAEKTAKDKACLTNLINNLEKKNWVIRKEGPSDRRNRLIFLTPQGEE
                     LALTVKPLINDIYAQTGAEMEASRITECIEDLKRLHEVLNEI"
     CDS             10780..11847
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg294_10"
                     /sec_met_domain="Biotin_lipoyl_2 (E-value: 4.6e-12,
                     bitscore: 36.2, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTRQIKLKQLRRLKFRNIFLNTVCILLALAGISWTVNYFWKYAR
                     YEITNDAVVDQYIAPLNIRIPGYIKEVRFTEHQYVHAGDTLLILDDREYRIRLKDAEAA
                     LMDALGSKEVLNSGIRTSGVNVAVQEANIAETLAHLSQQEAELNRYTRLLKKQAVSQQD
                     YELAKANFEATRARYNALLRQKEAAQSQYSETSKRSTGAEANILRKEADLEMARLNLSY
                     TVVTAPYDGYTGRRTLEPGQFVQGGQTLSYLVRGNDKWVTANYKETQIAHIYIGQKVRI
                     KVDAFSGRTFHGTVTAISEATGSKYSLVPTDNSAGNFVKVQQRIPVRIDLNDASPEEME
                     CLRAGMMVETEAVRP"
     CDS             11852..13447
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg294_11"
                     /sec_met_domain="MFS_1 (E-value: 1.7e-14, bitscore: 43.9,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKLNLPTRPWVPQWLGIVTMFIVIFPITLLNGAYTGSMVEVSNT
                     LGVLSEDITMAYYSASVGMAVAYPIVPKIRTIATPKTLLLTDLLLQIFFSLVCAKTGSM
                     DVIMVCSFCMGFLKAFVMLEFIILIRPLFSPKNVRSEFYAYFYPIVFSGGQLSMAITAQ
                     LAYHYQWQHMYYFVTILLLIAILFVICFFRYARRPMHIPFKEMDGRSMFIIATAFLLTL
                     YTFTYGKTLDWFASPKIRVYVFVIPLLIALFIHRQRTQGKPFVSLKPLFLHKSIIGYGF
                     MVLAMFLTATSSLVTNYMNSIIRVDSIHANSLSLWLLPGYVVGAVICFWWFRWQRWRFR
                     FLISGGMFCYVIYLAILYFGITPYGTYEMLYLPILFRGVGMMVIFIAFGVFVVEDLDPR
                     LTLSNAFFLISFRSVLAPVLSASFFNNMLYYLQAKGMNILSENMTLTNPLAEQKYNQAL
                     SNALAQGHEFGEAGQLAANSLYSTLQQQSLLLALKTLIGYVLILALVIAVIAAFIPFHK
                     TLKVAVVKTGDDMV"
     CDS             13447..13596
                     /locus_tag="ctg294_12"
                     /transl_table=11
                     /translation="MRRDTKKPPNCLSGFLKYKLNQVKLLNTRFGIYSANLLSEPSTLI
                     ILCL"
     CDS             complement(13542..14546)
                     /locus_tag="ctg294_13"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTRDMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCKNPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYDENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSSDHHT
                     YTEPDEVVDFVTKTGCDSLAISIGTSHGAYKFTPEQCHIDPKTGRMVPPPLAFDVLDGV
                     MKELPGFPIVLHGSSSVPEEEVATINQFGGALKAAIGIPEEELRKAAKSAVCKINIDSD
                     SRLAMTAAIRKVFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSDNKLAE"
ORIGIN
        1 tacccgggcg tactcgccgt ttggaaagct ctggaggatg ctcacgaacg aggtttccac
       61 catctggagt tcatggatgt gggacttcct ttccgtcggc atggttatcg cgatttcgta
      121 ctccgcttcg gaggaaaaca aagcagtacc cgacgttggt tccgcgtcag ttggccttgg
      181 ctgaataagt taatggtcaa attttacgtt taaatgcaat ctccagatta caaaaccatt
      241 cttcatgctc cctccctacc attttttata ctttatatcc caataattaa atgctgaaaa
      301 atttctttat taggtaagaa ttgtctttct ttgtgctgtt ttatgcctta taagcacaga
      361 tttaaaacca aataaaaaaa gtatagttat gaagatttca cacattgaac atttgggcat
      421 tgccgtaaaa agtatcgaag aagcccttcc gtattatgaa aacgttttag gtttgaaatg
      481 ctacaacatc gaaactgtag aagatcaaaa agtaagaaca gccttcctga aagtaggtga
      541 taccaaaatc gaattactgg aacccacatg tccggaaagt accatcgcga aattcattga
      601 aaacaaaggt gcaggtgttc atcacgtagc attcgccatt gaagacggcg tagccaatgc
      661 cctggccgaa gccgaaagca aagagatccg cctgatcgac aaagctccgc gcaaaggtgc
      721 cgaaggcctg aacattgctt tccttcaccc gaaatcaact ctgggcgtac tgacagaact
      781 ctgcgaacac taaaaagatg tacgattcgg acgatccgcg ccacggacaa acggaatttt
      841 tctttgcatt aaattcccca tccgggttgt caatcgtccg gttgtaaata ttataaccct
      901 ttaaattaag aaaaactcat gagtaaccag cttgaaaaag taaaagagct tattgaactt
      961 cgtgctcagg ctcgtttagg tggtggcgaa aaggctattg aaaaacaaca cgccaaaggc
     1021 aaatatacag cccgcgagcg tattgcacag ttgcttgacg aaggtagttt cgaagaactg
     1081 gatatgtttg ttcaacacag atgtaccaat ttcggacaag agaaaaaaca tttcctcggc
     1141 gacggtgtgg taaccggtta tggaacgata gaaggtagat tagtatatgt tttcgcacaa
     1201 gatttcacag tattcggtgg ttcactgtcg gaaaccatgg cacaaaagat ctgtaaagta
     1261 atggatatgg ccatgaagat gggtgcccct gttatcggta tcaacgactc gggtggcgca
     1321 cgtattcagg aaggcatcaa cgccctgtcc ggttatgctg aaatcttcca gcgcaacatc
     1381 atggcttcgg gtgtcatccc acagatttca ggtattttcg gtccgtgtgc cggcggtgcg
     1441 gtttactctc ccgccctgac ggacttcacg ctgatgacgg aaggtacatc ttacatgttc
     1501 ctcaccggac cggctgttgt gaaaacagta acgggtgaag acgtgtctca ggaagatctg
     1561 ggtggtgcaa gcgtacatgc cagcaagtcc ggtgtaactc acttcactgc cgaaaccggt
     1621 gaagaaggtc tggcgattat tcgcaagctt ctcagcttta ttccgcaaaa caacctggaa
     1681 gaagctccat tggtgaactg taccgacccc atcgaccgta tggacgacct gctgaacgag
     1741 atcatccccg acagcccgaa caaaccgtac gatatgtacg aagtgatcgg cgccatcatc
     1801 gataacggag aattcctgga agtacagaaa gactatgcga aaaatcttat tatcggtttt
     1861 gcccgtatga acggacaatc ggtaggtgtg gttgccaatc agcctaaata cctcgccgga
     1921 gtactcgaca gcaatgcttc acgcaaaggt gcacgcttcg ttcgcttctg cgacgcattc
     1981 aacattccgc tggtgacatt ggtagacgtt ccgggattcc ttccaggtac gggtcaggaa
     2041 tataatggtg taatcctgca cggagccaag ttgctgtacg cttatggtga agccactgtg
     2101 cccaaagtaa ctgttaccct gcgtaaatct tacggtggtt cgcacatcgt aatgagttgc
     2161 aagcaactcc gcggcgacat gaactatgca tggccgacag ccgaaatcgc cgtaatgggc
     2221 ggtgccggtg cagtagcggt attgtatgcc aaagaagcca aagatcagga aaaccctgct
     2281 caattcctgg cagacaagga agccgagtac actaaactgt tcgccaaccc atacaatgca
     2341 gccaaatacg gttacattga cgatgttatc gaaccgagaa acactcgttt ccgcgtgatc
     2401 cgcgccctgc aacagctgca gaccaaaaaa ttaaccaacc ctgctaaaaa gcacggtaat
     2461 attccattgt aacaaattaa acatcgattg ttatgaataa gaaaagaatc gggatattta
     2521 tcgctctgct ggcaatggtt tgcatggggc tcagggcgca aagtgccacc agtctgagaa
     2581 tcaatgaggt tttggtcgtc aacgaccaga actatcagga tgactacgga ctgcacaatg
     2641 cgtggataga gatattcaac acctctttcg cttctgtaaa tctggaaggt tgctttctga
     2701 cgaacgataa aaacaatccg accaaatatc ctattcccaa aggcgacgtg ctgactctga
     2761 tcaagccgcg ccaacatgct ttgttctggg cagacggaat gcctaaccgg ggtacgttcc
     2821 acgtgaactt tacgctcgac ccgaacaaag agaattacat tgctttgtat gactctaacg
     2881 gtaaaactct gattgacgaa gtaaccatac ccgccggtca gcttgccgac cgttcatacg
     2941 ctcgcgaaaa agacggaagt gccaactggg tagtaaaagg tgaaggagaa cacagctatg
     3001 tcactccgag caccaacaat atgactatcg acaaaaaccc gaagatcgag aacttcaaga
     3061 aacacgactc tatcggtatc ggtatggcca tcatcgccat gtcggtcgta ttcataggtt
     3121 tggtactctt gtatctttca ttcaaggcgg taggtaacgt agcggtcaga ctgggtaaga
     3181 aaaacgcgat gaaagccacc ggtatcaccg acaagacgga agcgaaggaa aagaacctgg
     3241 gtagccacac aggtgaagaa accgccgcga tcgccatggc tttgcatgaa tacctgaatg
     3301 acgctcacga cgttgaagac atgattttga ctatcaacaa agtgaaacgc acctactcac
     3361 cctggagttc gaagatctac acactgcgtc agactccgaa aagataatta ctaaccctaa
     3421 taaaatgaag caatgaaaca atataaatat aaaatcaacg gcaaccttta caacgttaca
     3481 gtgaacgatg tagaagataa catagccaac gttgaagtga acggaacctc ttataaagta
     3541 gagttggaca agcccgtcaa agccgctccg aaaccggtga cccgcccggc agccgctccg
     3601 aaaacggaaa caggtgctcc ggtagtaacc aaacaaccga cagcttccaa aaaagacggt
     3661 gtgaaatctc cgcttccggg cgttatcctc gacataaaag tgaaagaagg ggataccgtg
     3721 aagagaggcc agacgatcat catccttgag gctatgaaga tggaaaacaa catcaatgcc
     3781 aataaagacg gaaaagtagc agaaattaaa gttaataaag gagattctgt acttgaaggt
     3841 acagacctcg taatcattga ataattatgg gagatttcgt atcattctta gggaataacc
     3901 ttgttgactt ctggggatac accggttttg cgaacgcgac acccggacat cttttcatgt
     3961 tgctaatcgg tctcttcttt atctaccttg ccgtagccaa agaatttgaa ccgatgctgc
     4021 tgatccccat tggcttcggt attctgatcg gtaatattcc attcaatatg gaagccggat
     4081 taaaagtggg tatttacgaa gaaggttcgg tactgaacat cctttatcaa ggagtaacct
     4141 ccggctggta tccgccgctc attttcctgg gtatcggagc catgacggac ttctcggcgc
     4201 tgatctccaa ccccaaattg atgctgatcg gagctgctgc gcaattcggt atcttcggcg
     4261 cgtatatcat tgccctgctc attgggttcg aacccaacca ggcgggtgct atcggtatca
     4321 ttggcggtgc cgacggaccg acggccatct tcctttcgtc caaactggct cccaacctga
     4381 tgggtgccat cgctgtgtca gcctattctt acatggcgct ggtgccggtg atacagccac
     4441 ctatcatgcg tgcgctaacc accaaacacg agcgtctgat ccgcatgaaa ccaccgagaa
     4501 tagtatcgca tacggaaaaa gtaatcttcc ccatcgtggg tctgttgctt acatgcttcc
     4561 tggttccttc gggtctgcct ttgctgggta tgctgttctt cggtaatctt ctgaaagaaa
     4621 gtggagtaac ccgtcgtttg gcaaatacgg ccagtggtcc gttgatcgat gtgatcacta
     4681 tcctgttggg actgactgtg ggagcttcta cccaagcttc acaattcctc acctgggatt
     4741 ctatcttgat ctttatcctc ggtgcattct ctttcatcat cgcaacagcg tcaggtgtca
     4801 tgtttgtcaa attcttcaat ctattcttga agaaaggcaa taagatcaat ccgctgatcg
     4861 gtaatgcagg tgtatctgcc gtacccgact cggcacgtat ttcacaggta atcggtttgg
     4921 aatatgatcc gaccaactat ctgctgatgc acgccatggg tcctaacgta gcgggggtta
     4981 tcggttcggc tgtagctgcc ggtatcctgc tcggattcct catgtaaacg atattttttt
     5041 cattagtaag gtagacgttc ttcttttcgc aaagaagggc gtcttttttt tgcgttaatc
     5101 tatctaaaag atattacgaa tctttcgtag aatggatatt tttactaact tgcggacaat
     5161 aaaacaatac gtcctatgag aacaagaaca atgaaaccac tcttccttat tttctgtctt
     5221 tgcctcagtc ccctactgat gggccagaat caaaacaaaa ttcaggaagc aatggcaaac
     5281 tatgactacg agactgccgt tgaactgata aacaaggaac ctcccaccat cccactgtta
     5341 atgcagaaag caaaagccct gaaaggaatc ggcagcaatg cggaagctct acgttccatc
     5401 cgccaagtga tagcggaaga ctccaccaac caacaggcac acatcgaagc agcggaatgc
     5461 tgtaaagcaa tggccaagta caacgatgcg ctggactact accggaaagc catcagcctg
     5521 aatcccaaaa acaagtatgc ccgtttgcaa ttcatcaacc tgctttgcaa caccaaaaac
     5581 tatgctgagg cttttggaga aagttcaatg atgtccgaaa cggacagttc ggccgtagtg
     5641 ctccacctac aggctcaaag ccttgaaggg atgcaacaga tactaccggc tatcggttgc
     5701 tatgaagtca ttcaggataa atatccggac gattatctgg ctgcggccaa actcggaaac
     5761 ctgaacattg tggctggata tcccgaatat gccatccaag ctaccgaacg ctatagggaa
     5821 cgggactcca ccaacctgat tgtcaaccag caaaacgctc tcgcctactg ccacgccgaa
     5881 caatatccga cagccatcaa gcgctatgaa aagctgtgcc aacaggggga cagcagtaca
     5941 cagaccttat actacctggg agtcagctat tacgcggatg aatattatta cgaagcgcac
     6001 gcgtgtttca gcaaactgca aaaagagatg gaagaaaatc ccaatctgct ctattatctg
     6061 ggacgttgct gcgccaagac ttcctggaaa aaagaaggca tcgaacacct ggagaaagct
     6121 atcgaactga ccattcccaa agacagcacc atgatccgac tttacaaagg cttggtggat
     6181 tgttgtaaac tggctcagga tactccaaag caaatccagg ctctcagaga actgtacaaa
     6241 tatgacaaga cgaaccataa acttctttat gacatcgcct ggaactattc atatcaactc
     6301 aaagacaaca aatcggccga acgttatctg caggctttct taaaaacccg aaaggcgaat
     6361 gccaggaaag aagaaccggt gagtgagaaa ggggaacttg tactcggact tgaaaattat
     6421 tacaacgctg ccgaaaattg gctgaaagac ttacagaaag aaaagttctt caaagaagga
     6481 ataccgttag aaagtcagaa acaatagaat ctgtcccccc ccatgaaaca ttggatactc
     6541 ctcctctatc tggggttcag cgtagtgctg caagcccaga acaccgcctc cgttcaagaa
     6601 gcaatggcaa actatgacta taaaacggtg atcagactga ttgatgaaga aagtgcatca
     6661 ccacagttac tcatacagaa agccaaagct ttaaaaagtt tagggcgtac cgccgaagcc
     6721 ctgtccactt tgcaacatat cattatcgag ctgcccgaaa atcagcaggc attggtagag
     6781 gcagcagaat gttgcaggca attgagcaaa tttaacgagg ccttggggta ttatcggaag
     6841 gtgatggaac tcaatcccga acatatttac gcacacttgc aatacacccg cttgttatac
     6901 aactatcagc gatacggcga tgcattgcgt gagagtatcg cattggccag gaaagacagt
     6961 tccgccaccg tattgcgact gatggcggaa agcatggaag gagccggcat gccggtagaa
     7021 agtatgtttt gctatctttc catcatcagg aaatatccct ccgactatct ctcggtagct
     7081 aagctgggca gtatcttcaa tacaatgaaa gattacgaag gggcaattgc cctgacagaa
     7141 gcataccgcc ggacggacag caccaatgta gaagtgaacc gtcaaaacgc actggcgtat
     7201 tgtctgcgca aagaatatcc caccgccatc aaacgttatc aggatctgac cgcccgggga
     7261 gacagcacac tgctgacatg ttattacctg ggagtcagct actacgctac gaaagaatac
     7321 tataaagcgc gcgattggct actcaaagca aaatcatgcc agtcacccgg cgccaaccta
     7381 ctctactatt tgggacgttc gtgctccaag acattatgga aacaagaggg aataggatat
     7441 ctgaaccagg ctatcgccct gactatcccc gccgacagta tcatggagcg cttatactca
     7501 ggcttggcag actgctacag gcaaaccaag caaacccggg accaaatcaa ggctaccaaa
     7561 gaacaataca aatatgcccc tgacaagcat attttacttt ataacttggc gttcttatcg
     7621 gacaaaatag gagatactaa agccacagag cattacttgc aggcttttct gcgaacaaaa
     7681 tccaaacaaa atgcagtact acagcagccg gatgatgacg aagaagaacc cgcaccctac
     7741 atagattact acaaaagtgc caccaataaa ttggaaagca tccgaaaaga gaaattctta
     7801 aagggagaaa agtgaattga tcggatagat gcatcgtttc ggacaattca ccactgagtg
     7861 cagacagagt ttcacagagg gagaataatg gaaaataaat ttgaagatgt gcggtagaag
     7921 gcacagtggc acgtaaccga agtcacatcg gcacgcagcc gaaattacgg tgctgtgtag
     7981 ctaaagttac ggtgctgcgt agccaaagtt acggtgctgc gtagccaaag ttacggtgct
     8041 gcgtagccga agttacggtg ctgcgtagat aaagttacgg tgctgcgtag ccgaagttac
     8101 ggtgctgcgt agccgaagct atgacggcat ctccttttcc ggacgtcacg ttcacctgat
     8161 tgcatcgaaa agtgttcctt atcggttgag ctccatcccg gagaattctc caatgaaaac
     8221 gtttgcataa atagatggca cacagtaaga aagaaaacgg aaaacaatcc gatgatttac
     8281 cctatattag caacattaaa taataacgag ctaatatcat gaaaaaatta ttgttactct
     8341 taggttcatt cctactgtca ttaaccactt atgcagccat gaacatatcc aaaatcgatc
     8401 cgcccttctg gttcaccggt atgaacaatc cggaactcca gttaatggta tacggtgaag
     8461 gcatcggcca ggcatccgta tcagtaaatt atcccggtgt atcgctcagc agcgtcgtga
     8521 aactggaaag caacaattac ctgcttgtct acctgcatct cgataaagaa gtaaagccgg
     8581 gcaagatgcc catcacattt acggtcggaa agaagaaatt ggtgaaagag tacgaattga
     8641 aagcacgcag caaagccgga gtcgatcaca aaggttttga cgcatcggat gcattatacc
     8701 tgctgatgcc ggaccgtttt gccaatggca atccggataa cgaccggata gaaggcatgg
     8761 ccgaatataa agtggaccgc aacgacccga acgcacgtca cggaggcgac ctggccggta
     8821 tcgaacaaaa tctggactat tttaccgact tgggagtgac cgcactctgg ttcaccccgg
     8881 tactcgaaaa taatatgaaa ggcggctcat atcacggata tgcaacaacc gattattaca
     8941 aggtagaccc acgtttcggc actaacgagg aatatcgctc actgatagcg aaagcccaca
     9001 accggggcat taaggtcgtg atggacatga tcttcaatca ttgcggagta gaacatccct
     9061 ggatcaagga catgccttca aaggactggt tcaaccatgc ggacttcaag aacaactttg
     9121 tgcaaacttc ctacaagctg actccacatg tagatccgta tgcctcggag tacgatttcg
     9181 accagatgaa caacggctgg ttcgtggaag ccatgcctga cctcaaccaa aagaaccctc
     9241 acgtatacaa atacctcttg cagaacagcc tgtggtggat tgagtacgcc gatatcgacg
     9301 gcatccggat ggacacctac ccgtatgccg attacgatgc catgagcaac tggatgaaag
     9361 aactgaacga agaatacccc aactacaaca cggtgggcga aacctgggtt accgaaccgg
     9421 cctatacagc ctggtggcag aaagactcca aactctccgc cccgcgcaac agtcacttga
     9481 aaacagtcat ggatttcagc ttcttcgaca aagtcaacac ggccaagaat gaacaaacgg
     9541 acacttggtt caaaggattg gaccgtgtct acaacaattt tgtatacgat tatctgtatc
     9601 ccaatccggc ttccgtactg gctttcatcg agaatcatga caccgaccgt ttcttgggtg
     9661 aaggcgaaaa cctcgatatg ctgaaacagg cctccaccct tttattgacc acccgacgca
     9721 tcccgcaact ctattatgga acggaggtga tgatgaacgg agtaaagagt aaaagcgacg
     9781 gctatgtacg aaaggacttc ccgggcggat ggacggacga taaagagaat gccctgactc
     9841 ccgagggacg tacccgattg cagaatgaaa gctataactt ctaccgcaac ctgctgaact
     9901 ggcgtaaggg caacgatgtg atcgccaaag gcagcatgaa acagttcatg gtgcagcacg
     9961 gcgtatatgc ttatgcacgc caatataaag ggaaaacggt attcgtcctg ttgaacggta
    10021 cggataaaga ggtgaaactt cccctgaaat actatgccga agtgctgaaa gacaagactc
    10081 aaggaaaaga cgtcattagc ggaaaagtaa cggcactcaa tgaagaactg acaatggcac
    10141 cccgccaatc gatggttata gagctttaat ctcacaccgg ttataaccgc ataagcaaag
    10201 ggcacaaagg atttcacccg acatcctctg tgccctttgt gtagcctaat gcgaataata
    10261 atagtcaaac gtttgactat tatcggagaa tattcctacc tttgcagcga ctaaaagaat
    10321 acgacgatga caaacaacga atcggagcgc gagctcgtcc tacaaacctt acgaacctgg
    10381 atggcattcc gccaggccgt tcagcgggta ctcaaacgcc acaacgtgga tatgaccttc
    10441 gagatgctgc aagtaatgaa ctgcctgtgg aacaaacaag gcatcagcca gcaatccctg
    10501 gctgagaaaa cagcaaagga caaggcttgc ctgaccaatc tgattaataa tctggaaaag
    10561 aaaaactggg tgatacggaa agaaggcccc tccgaccgcc gaaaccgcct gattttcctg
    10621 acgccccaag gcgaagaact tgccctcacc gtgaaacccc tgatcaacga tatctatgcc
    10681 caaaccggag cagagatgga ggcaagccgg ataacggaat gcatcgaaga cctgaagaga
    10741 ctgcatgaag tgctcaatga gatctaaaag aaatccgcca tgtccacccg tcagataaag
    10801 ctaaaacaat tgagaagact gaagttcagg aacatctttc tcaacacagt atgcatcctg
    10861 ctggcattgg caggtatttc atggacagta aactacttct ggaaatacgc ccgctacgag
    10921 ataaccaatg atgccgtagt ggatcaatac atcgctccgc taaacatccg gataccgggc
    10981 tatatcaaag aagtacgttt taccgaacat cagtatgttc atgccggcga cacgttactg
    11041 atactggacg accgggaata ccggatccgg ctgaaagacg cggaagcggc cttgatggat
    11101 gccttgggat caaaggaagt gttaaactcc ggcatccgga cttcaggagt aaatgtagcc
    11161 gtgcaggaag ccaacatagc cgaaacactg gcacaccttt cacagcaaga agcggaactg
    11221 aaccgatata cccggctcct gaaaaagcag gccgtcagcc aacaggatta tgaactggcc
    11281 aaagcgaact tcgaagcgac ccgggcaaga tacaacgccc tgttgcgaca aaaagaagcg
    11341 gcccaatcgc agtattccga aaccagcaaa cgcagtacag gcgccgaagc caatatcctc
    11401 cggaaggagg ccgacctgga gatggcccga ctaaacctgt cgtataccgt tgtcaccgca
    11461 ccctatgacg gatacacggg acgacgtaca cttgaaccgg gacagttcgt acaaggcgga
    11521 caaactcttt cctacctggt acggggcaat gacaagtggg tgacagccaa ttataaagag
    11581 actcaaattg cccatatcta tatcgggcaa aaagtccgca tcaaagtaga tgctttcagc
    11641 ggacgcactt ttcacgggac cgtaaccgcc atttccgaag ccaccggatc gaaatactcc
    11701 ctggtaccga ccgacaattc ggcagggaac ttcgtcaaag tgcagcaacg cattccggtc
    11761 cgcatcgatc tcaatgacgc ctcacccgaa gagatggaat gtctccgtgc agggatgatg
    11821 gtagaaacgg aagcggtccg cccttaggct tatggtgaag ctcaatctgc ctacccgtcc
    11881 ctgggtgcct caatggttgg gcatcgtgac catgtttatt gtcatctttc ccatcaccct
    11941 gctcaacggt gcctacacag gaagtatggt cgaagtatcg aacacgctgg gagtattgag
    12001 cgaagatatt accatggctt actattcagc ttcggtaggg atggctgttg cctatcccat
    12061 cgtaccgaaa atacgcacca tagccactcc gaaaacctta ctgcttaccg acctgctgct
    12121 acagatattc ttcagcctgg tatgcgccaa aaccggtagt atggatgtca tcatggtatg
    12181 cagtttctgt atgggatttc tcaaagcctt cgtcatgttg gagttcatca tcctgatccg
    12241 cccgctcttc agtccgaaaa acgtacgaag tgaattctat gcctacttct accccatcgt
    12301 tttctccgga ggtcagctat cgatggctat caccgctcaa ctggcctatc actaccaatg
    12361 gcagcacatg tactattttg tcaccatcct cttgctgatc gccattctgt tcgtcatctg
    12421 tttcttccgc tatgcaaggc gtcccatgca cattccgttc aaagaaatgg acggaagaag
    12481 catgttcatc atcgccaccg ctttcctgct aacgctctat acatttacct acggaaaaac
    12541 actcgattgg ttcgcatccc cgaagatcag agtatatgta ttcgtcatcc cgctcctgat
    12601 agctcttttc atccatcggc agcgtacaca aggcaaaccc tttgtcagcc tgaaaccact
    12661 ctttctgcat aaatccatca tcggatatgg cttcatggta ctcgccatgt tcctgacagc
    12721 caccagttca ctggtaacca actatatgaa cagcatcatc cgggtagaca gcatacacgc
    12781 caattcgctg agcctgtggc tattgcccgg atatgtggta ggggccgtca tttgcttctg
    12841 gtggttccga tggcaacgat ggcggtttcg cttcctcatt tcaggaggta tgttctgcta
    12901 cgtcatctat ctggctatcc tctactttgg tatcacccct tatggaactt atgaaatgct
    12961 ctacctcccc atcctgttcc ggggagtggg gatgatggtc atattcattg cgttcggtgt
    13021 gtttgttgtc gaagatttag acccgcgcct gacgttgtcc aatgccttct tcctgatttc
    13081 attccgctca gtattagctc cggtcctgtc cgcttcgttc tttaacaaca tgctttacta
    13141 tctgcaggca aaggggatga acattctttc ggaaaacatg acgctgacca atccgctggc
    13201 cgaacaaaaa tacaatcagg cattgagcaa tgccctggcg caagggcacg aattcggcga
    13261 ggccggacaa ttggcagcca acagtctgta ctccactttg cagcagcaat ccctgttgct
    13321 tgccctgaaa accctaatcg gctatgtact gatactggca ctggtgattg ctgtcatcgc
    13381 agcgttcatt cctttccata aaacgctgaa ggtggctgta gtgaagacgg gtgacgatat
    13441 ggtataatga gaagggatac aaaaaagcca cccaattgct tgagtggctt cttaaaatat
    13501 aaattaaatc aagtaaaact tttaaatact agatttggaa tttattcagc taacttgttg
    13561 tcagaaccca gcacgttgat aattttgtgc ttgtagagtt tttccatatt gtcgcgagcc
    13621 ggtcccagat atttacgcgg gtcgaactca gccggttttt ctgcgaatac cttacggata
    13681 gcagcagtca tagccaggcg agagtctgag tcgatgttga ttttgcaaac agcagactta
    13741 gcggctttac gcagttcctc ttcaggaata ccgatagcag ctttcagtgc accaccaaac
    13801 tggttgatag ttgcaacctc ttcttcagga actgaagatg atccgtgaag aacgataggg
    13861 aatcccggaa gttctttcat tacaccgtcc aatacgtcga atgccaacgg aggaggaacc
    13921 atacggcctg tcttcggatc gatgtggcac tgttccggag taaatttgta agcaccgtga
    13981 gaagtaccga tagagatagc caatgaatcg caacctgtct tggtaacgaa atcaactact
    14041 tcgtccggtt cagtatatgt gtggtggtca gaagaaactt cgtcttctac acctgccaat
    14101 acgccaagtt caccttctac agttacatcg aactggtgag cgtattcaac aactttctta
    14161 gtcagagcaa cgttttcgtc gtaaggaagg tgagaaccgt cgatcattac agaagagaag
    14221 cctgagtcga tacagctttt gcaagtttcg aaagtatctc cgtggtcgag gtgcaaaacg
    14281 atttcaggat ttttgcagcc gagttctttt gcatattcta cagcaccctg agccatgtaa
    14341 cgcaacaatg tagcgttagc atactgacga gcaccttttg atacctgcaa aataaccgga
    14401 gacttagttt ctacagcagc cttgatgata gcctgcatct gttccatatt gttgaagttg
    14461 aatgcaggga ttgcatatcc acccttgata gccttagcaa acatatctct agtgtttacc
    14521 agacctaaat ctttgtaatt aaccattttg tttaaaagtt tattgttagt gaattaaaaa
    14581 ttctatgcaa aagtaagaat aatcctttga atagagaaac cctcgggcgg aaatatccgt
    14641 ttgaggagcg taattcaatt ctatttcaaa ttatttccca tcctttaaga gctgtttgta
    14701 atgtctacgt agcaaataaa ggttttttat tgtttcctca tatatataat ggtaggcaaa
    14761 tgatcgctgt aaccatccaa ccacactctg ccaccatatg tacgcagggg tgcaccctta
    14821 tatttaccat cctgctgaaa caggtaatcg cgcatgaaaa cttcattgtg atcatatttc
    14881 aatccttttg tggcttgaag cagcgtgggc gaaaggatga tctgatcgaa cagattccat
    14941 ttgccgcgat agagcaaagt gcccactccc ttatcttcca gcgtcaccca ccaggggttg
    15001 taaaggtcat cttcagtcat atcttcg
//
