LOCUS       c00316_gnlPro..        10428 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CKBAFCEP_316.
ACCESSION   c00316_gnlPro..
VERSION     c00316_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 12:21:33
            Original ID  :: gnl|Prokka|CKBAFCEP_316
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10428
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10428
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2801:8883]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2802..8883
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..10428
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..10428
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(2..712)
                     /locus_tag="ctg316_1"
                     /transl_table=11
                     /translation="MVYDLTMLKTFYAAYSEKIERVRNVLRRPMTLAEKILYAHLYDGD
                     KVKNYRRGEDYVNFRPDRVAMQDATAQMALLQFMNAGREQVAVPSTVHCDHLIQAYKGA
                     KEDVATATKTNEEVYNFLRDVSSRYGIGFWQPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRLIGVHLKGKLSGWVAPKDVILKLAGI
                     LTVKGGTNAIIEYFG"
     CDS             827..2740
                     /locus_tag="ctg316_2"
                     /transl_table=11
                     /translation="MITFATMKEQDSNSPIIHLQQQQLLLRMEYEYEKEEFKRQTENMG
                     VARKVKRGLCWYPATPGRSYYNSLNQLVIEITHTENTDIEHNFEFGRPVCFFRQSADGK
                     ITYMNFTATVSYADETRMVAIMPGAGAVMEVQETDNLGVQLYFDETSYRTMFEALEDTL
                     RSKGNRLAELRDILLGTSKAGFRELYPVRFPWLNSTQETAVNKVLCARDVAIVHGPPGT
                     GKTTTLVEAIYETLHREPQVLVCAQSNTAVDWISEKLVDRGVNVLRIGNPTRVNDKMLS
                     FTYERRFENHPLYPELWSIRKNLRELGSRARRGSYDEREGVRSRMSRLRDRATALEIQI
                     NAELFDGAHVIASTLVSSNHRLLNGRRFGTLFIDEAAQALEAACWIAIRKADRVVLAGD
                     HCQLPPTIKCYEAARGGLERTLMEKVVSNKPAVVSLLKVQYRMHEEIMKFPSQWFYNGE
                     LEAAPEVRYRGILDWDTPIHWIDTSEMDFKEEFVGETFGRINKAEADLLLSELKIYINR
                     IGGNRILEEKIDIGIISPYKAQVQYLRSKIKADASLKPYRSLFTVNTVDGFQGQERDVI
                     FISLVRANEEGQIGFLNDLRRMNVAITRARMKLVILGEAETLKHHGFYRKLLEFIQNIG
                     NQ"
     CDS             complement(2802..3845)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg316_3"
                     /sec_met_domain="IlvN (E-value: 3.4e-47, bitscore: 149.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.1e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIIMCLLSDAAVMS
                     VWPTIKPYLTPGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(3896..4648)
                     /locus_tag="ctg316_4"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVAAL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             complement(4645..5205)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg316_5"
                     /sec_met_domain="ALS_ss_C (E-value: 5.4e-20, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQES"
     CDS             complement(5238..6989)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg316_6"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.6e-48, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRKAAELI
                     NGAKRPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             complement(7081..8883)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg316_7"
                     /sec_met_domain="ILVD_EDD (E-value: 4.9e-219, bitscore:
                     717.3, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQFVKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRKRLFEDAAKLIVANAFRYYEEGDESVLPRSIATREAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGADFKMDDIDMLSRKTPCLCKVAPNTQKYHVQDVNRAGGIIAIMDELAKGG
                     LVDTNVRRVDGMTLAEAIDRYSITSSNVCKEAIKKYSSAAAGKFNLVLGSQNASYKELD
                     TDRATGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQDA
                     ACDGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIKDGDIIEIDIPNRSINVKLTDEELAARPMTPVTRNRE
                     VSKALKAYASMVSSADKGAVRLID"
     CDS             9374..9946
                     /locus_tag="ctg316_8"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYSIENGEKDFEEEAPVEHPFQFISGLGMTL
                     EPFEAQIKDLQIGDKFDFTIPASEAYGEYDDDHVIDLPKEIFMIEGEFDSDRVVEGAVI
                     PLMTSEGQRINGSVVEVKEDVVVMDMNHPLAGCDLNFTGEVVESRPATNEELAEVARMM
                     GGGCGSCGCGDCGDGCGDHECGGGCCH"
     CDS             complement(10054..10428)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg316_9"
                     /sec_met_domain="SDH_alpha (E-value: 2.6e-40, bitscore:
                     127.9, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="YIKQSLGRLSALCGCVVAATGSSCGITWLMGGTYEQVAYAVQNMI
                     ANLTGMICDGAKPSCALKVTTGVSTAVLSAIMAMENRCVTSVEGIIDEDVDQSIRNLTK
                     IGSKGMNETDKLVLEIMTSK"
ORIGIN
        1 gtccaaaata ttcaatgatg gcattggttc ccccttttac agtaagaata cccgccaact
       61 tcagaataac gtctttggga gctacccagc cactcaattt acccttcaag tgtacgccta
      121 tcagacgcgg cattttcagt tcccattcca tgccggtcat cacatccacc gcatcggcac
      181 cacccacacc aatggccacc atacccaaac ctccggcatt gggcgtatga gagtccgtgc
      241 ctaccatcat tccacccgga aatgcgtagt tctccaatac cacctggtga ataatacctg
      301 ctcccggctg ccaaaaacct atgccatagc gggaagaaac atcacggaga aaattataga
      361 cctcctcgtt ggtcttcgta gcagtcgcaa catcttcttt tgcaccttta tatgcttgaa
      421 tcaaatggtc acagtgcaca gtggaaggca cggcaacctg ctcacggcct gcattcataa
      481 attgcaataa ggccatttga gccgttgcat cctgcatggc cacacggtcg ggacggaaat
      541 tcacatagtc ttctccccgt ctgtagttct tcactttatc cccatcatac aaatgagcat
      601 acaaaatttt ctccgctaaa gtcatcggac gccgcagtac gttccgtacg cgttctatct
      661 tctccgaata agcagcataa aacgttttga gcatcgttaa atcatatacc ataaccacta
      721 ttttttagtt tttcattatt gtaaagatta caaattaata tcataaacaa ataaaaaggc
      781 tgaatagttt aacaaaataa agcatttttt ccgtcggaag cgaagaatga ttacctttgc
      841 aaccatgaag gaacaagatt caaatagtcc tattattcac ctccaacagc agcaactttt
      901 gctgcgcatg gaatacgaat acgaaaaaga ggaattcaaa cgccaaaccg aaaacatggg
      961 agttgcccgg aaagtgaaac ggggactttg ctggtatcct gccactccgg gacgaagtta
     1021 ctataattca ctgaatcaat tagtaataga aattacacac acagaaaata ccgatataga
     1081 acataatttt gagttcggcc gtcccgtatg ttttttccgc cagtctgctg atggaaaaat
     1141 aacctatatg aacttcaccg ctaccgtaag ctatgccgac gagacacgga tggtagcgat
     1201 aatgcccgga gccggtgccg ttatggaagt gcaggaaacg gacaacctcg gcgtgcaact
     1261 ttatttcgac gaaacatcct atcggaccat gttcgaagcc ttggaagata cgttacgctc
     1321 caaaggcaac cgcctggccg aattgcggga catattgctg ggaacctcga aagccggttt
     1381 ccgagagctc tatcccgtac ggtttccctg gctgaactcc acgcaggaga cagctgtaaa
     1441 caaagtgctg tgtgcccgcg acgtggccat tgtacacggt cctccgggaa ccggaaaaac
     1501 gaccacctta gtggaagcca tctacgaaac cctgcatcgg gaaccgcagg tactggtatg
     1561 tgcccaaagc aatactgccg tcgactggat ttcggaaaaa cttgtggacc gtggcgtcaa
     1621 tgtcctgcgt atcggcaatc cgacccgtgt caacgacaag atgctttcct ttacctacga
     1681 gcgtcgtttc gagaaccatc cgctttatcc ggagctgtgg agcatccgga aaaatctccg
     1741 tgaactgggc agccgtgccc gccgtggcag ctatgacgaa cgcgaaggag tacgcagccg
     1801 tatgagccgc ctgcgcgacc gcgccaccgc attggaaata caaatcaatg cagagctttt
     1861 tgatggggca catgtcatag cctccacgct agtaagcagc aatcaccggc tgctgaacgg
     1921 acgccgtttc ggcacccttt tcattgatga agcagcccag gccttagaag ctgcctgctg
     1981 gatagctatc cgaaaagcag accgcgtggt gttggcgggt gaccactgcc aacttccgcc
     2041 cactataaaa tgctacgaag ctgcccgtgg aggtctggaa cgaacattga tggagaaagt
     2101 ggtgtccaac aaacctgccg ttgtctcttt gctgaaagta caataccgca tgcacgagga
     2161 aatcatgaaa tttccttccc aatggtttta taatggcgag ttggaagccg ctcccgaagt
     2221 gcgttaccgg ggcatcctgg actgggatac ccccatccac tggattgaca cctccgaaat
     2281 ggatttcaaa gaagaatttg tgggagagac tttcggacgc attaataagg cggaagcgga
     2341 cctgctccta tcagaactga aaatctacat caaccgtatc ggtggcaacc gcattctgga
     2401 agaaaaaata gacatcggca tcatctcccc ttacaaggca caagtgcaat atctccgcag
     2461 caagataaag gcagacgctt cactcaagcc ttatcgcagc ttgttcactg taaatacggt
     2521 ggatggcttc caagggcaag agcgcgatgt tatcttcatc agccttgtcc gtgccaacga
     2581 agaaggacag ataggattcc tgaatgattt aaggagaatg aatgtagcca tcacccgggc
     2641 acgtatgaag ctggtgatat tgggagaggc agagacgctg aaacatcacg gtttttaccg
     2701 gaagctattg gagtttattc aaaatatagg gaatcaataa taaagaaata ccccctccgg
     2761 taacaccgaa gagggtattt cacctattta tataaagctg attaattgtt ttccggacga
     2821 agtttacgaa ctgtaacagc tgtctgccac atttcgcttt cacgcaaggc tttcaattct
     2881 gcattcagct tctcacgata atcgggtttg gagttactgt cgatagaaat ctgagcttcg
     2941 ttgcccgact tcacacttgc atacaatttc tgtacaaccg gcttgatggc atcatggaac
     3001 ggggtcatcc aatccagcgc accacgctgt gccgtagtag aacagttggc atacatccag
     3061 tccataccgt tcttggcaaa caatggcatc aaagattgag tcaactcttc cactgtttca
     3121 ttgaatgctt cagaaggagt atggccgttt tcgcgcaata cttcatactg agccaacagc
     3181 aatccctgga tagcacccat caatgaaccg cgttcaccgg tcaagtcgga agtggcttcg
     3241 cggatgaaag ttgtctcgaa caaatatccc gaaccgatgc cgatacccag tgcaatcgtc
     3301 ttgtcaaaag ccttacccgt agcatcctga tagacggcat atgatgagtt caagccacga
     3361 ccctcgagga acatggtacg aagtgaagta ccggaacctt tgggagcaac cataataaca
     3421 tcaatatctt taggaggaac cacgccggta cggtcgttcc aggtaatagc aaaaccatga
     3481 gagaagtaaa gagcctttcc gggagtcaaa taaggtttga tagtcggcca tacagacatt
     3541 acagctgcgt cagacaacag acacatgatg atagtacctt tctgacaagc ctcttcgatg
     3601 ccgaacaaag tctcacccgg tacccatccg tcagccacag ccttttcgta tgtcttaccc
     3661 ggacgttgtc ctacaatcac attgaaaccg ttatcacgca agttgcaagc ctggcccggg
     3721 ccttgtacgc cataaccgat tactgcaatt gtttcatctt tcaaaatctc acgtgctttt
     3781 tccaaaggaa attcttcgcg ggtcattaca ttctcaataa caccgccaaa attcaattgt
     3841 gccatttttt gttttaattt ttatttgtgg cttacgccaa cgttgataaa tttatttatt
     3901 tctctgtaaa tatcacttta gagcgacaga ccacttcgct gccattcttt ttcacctcca
     3961 catcgtaaac gccctcaccg gcatcatcca tgaacaaagt caactcatcc ccataatagc
     4021 tttcggctac atatgccatt tcaaaacgac ggatgcgctt ctccttatac atctctatcg
     4081 ggaacaaatc aaggatatgc tcgatgtaac ggatgctgtt cacatgcccg ttaatgtcaa
     4141 tatcactgta tttggctacc aaagcagcaa ccggttcctt tgaggccacc tttatccgcg
     4201 aaggtttttc tatcgggcaa ggctcatcgc aaacataatc tacaatgctg ccactatgaa
     4261 gagccagcaa atctgccggc ttacgggtat tcatgctaat catcgcccaa acggaacgtg
     4321 catacccaat cttcttaccc tccttatcga tgatagcgaa attacggtct gtaaaaaggc
     4381 gatagacatt ctccacccaa gtctgaatgg agaaatcttc gtactgataa ggcatttcat
     4441 ccagttcgac agccagacgg gacaataccc aagtataatt gtcctcgttt agagtcgcga
     4501 tgccaaaacc gcggtcgctg gcatggaaac ccgcacaatt caacaaatgg ttgcccaata
     4561 ctcccattgt cagccgtccg gtaaagtcga catgaaacgg ttcggcaaca aacttgtagg
     4621 tacctatttt attgttctcg ctcatcatga ttcctggtgt ttactttgac gatattttgc
     4681 ttcacggtcc gccagatatt cattgacacg ctcaaagcag ctggtcgtaa tggctacgcg
     4741 acccgaacgg acgaactgaa gtacgcaatc caactggcgc aactcctcat aaagattggt
     4801 tatttcctca ctcatgccat tcttctcaac aatggcaaat acagcattca cctccacaat
     4861 acgggcattg tacttacgga ttactttgga cacctccggt ttttcttcca gcgtaggggt
     4921 cgttatttta taaagggcaa tctcgtgctg atagatttca tcatccgtga aataatgggc
     4981 ttgcagcaca tctattttct tggtaatctg cttggtcacc ttttcaatgg tatccttatc
     5041 cgtccaagcg gtaatggtat atttatgtac ccccttgatg gaggaggccg atacattcaa
     5101 actctcgatg tttatctgcc ggcgggtaaa cacagccgtc acctgattca gcaaaccggc
     5161 aaagttttcc gaatgaacaa tgattgtata tagtttttta tccatagata gagtaaattc
     5221 tttaatttcg catgacttca gcattccaac aacatctgat tgaccgaacc gcccggaggt
     5281 gtcatcggca ttacatttcc ttcttcctcc acacaagctt cgagcaggaa cggtccgtca
     5341 gtcgctatca tctcgtcaat cgcttttgcc agctcctcgc gggtcattac cctgcgtgca
     5401 ggaatatcat atgccgaagc aatcttcata taatccggat tcatcatcgg agtaaacgaa
     5461 taacgacgat tgaagaacat cgcctgccat tgacgaacat tgcccaagaa gttattgttc
     5521 aacagaatca tcttcaccgg agccttttgt tccatgatgg tacccagttc ctgcaggttc
     5581 atctgcaagc cgccgtctcc catgaatacg cataccgtgc ggtccggacg tccaaaagtg
     5641 gcaccgatag ctgccggaag gccgaagccc atagtaccca ggccaccgga agtaacaatg
     5701 ctacgttcct tgctgtattt gaaataacgg gcggacatca tctgattctg gccgacatca
     5761 gtcaccaata tcgcctcgtt atgggtagcc tcactcacag cacgcaccac ctcacccatg
     5821 cttagcgctt ttcctgccgg atgtaattcc ggacggatta ccttttcctc ttccacttcc
     5881 tcgtattgcc ggaaactgtc aatccattcc tgatggttgg cgggttccag caattgggta
     5941 acggcagcca gtgtctcttt gcaatctccc aggacagcaa catcagtctt tacattctta
     6001 tctatttcgg cagggtcaat atcaaagtgg ataatcttcg cctgcttggc atatgtttcc
     6061 aatttacccg tcacacggtc atcaaagcgc atgcctacgg cgataaggac atcacattta
     6121 ttggtattga tattgggccc caggttaccg tgcataccaa gcattccttt gttcaacgga
     6181 tggttcgtag gtaatgcgga aagtcccaat aaagtgcatc cggcaggcat tccggctttc
     6241 tcaatgaaag cacgaagctc ttgctgggct tctcccagct ccacgccttg tccaaccagc
     6301 accaaaggcc gtttcgcacc atttattaat tcagcagcct tccgtatggc ctccggctcc
     6361 atttcgggaa cgggaagata gctacggaca tagtccacct tagtaggcgc atattctgtt
     6421 ttctccactt gggcgttttt agcaaaatcc agcacgaccg gtcccggacg tccgctcttt
     6481 gccacataga aagcacgtgc cactgcccag gccacatctt ctgcacgacg aatctggtaa
     6541 ctccatttcg tgataggctg agtaatgcct accaagtcca cttcctgaaa tgcatccgta
     6601 cccaagaagt tcgtccctac ctggccggca atgacaacga taggcgtact gtcaatcatg
     6661 gcatctgcaa tgcccgtgat agtattggta gcacccggtc cactggtaac cagacaaacg
     6721 ccaacctcgc ctgatacacg tgcaaagcct tgtgccgcat gggttgctcc ttgttcatga
     6781 cgaaccaaga tgtggttcaa ttccttccga tggtcgtata aggcatcgaa taccggcatg
     6841 atgctccctc ccggataacc gaaaatagtc tttactccct gatgctccag agagcgcatc
     6901 aatgcttctg cgcctgttat tagagcctca ccccgaccct ctccttggga gagggaggaa
     6961 aagttactct ttttattatt atcagccata ctttatctat tcattatatt taaaagctca
     7021 atagtagctt gaaaaatttg tttcattctc tcctcccctc gctttcggaa aggggggctt
     7081 ttaatcaatc agcctcacag cccctttgtc agcggaactc accatactgg catatgcttt
     7141 caatgctttg gagacttcac ggttgcgggt taccggagtc atagggcgtg ctgcaagctc
     7201 ttcatccgtc aacttcacat tgatagaacg gttcggtata tcaatttcga taatgtcccc
     7261 atccttaatc ttgccgatat taccaccggc agccgcttcg ggagaaacat gtccgatact
     7321 tagtccggaa gtaccgccac taaaacgccc gtcggtaatc aatgcacact ccttacccag
     7381 atggcgggat ttgatataag aagtaggata aagcatctct tgcatacccg gtccaccttt
     7441 cggcccttcg tgagtgatga cgacgacgtc tccactgacc acctttccac ccagaatacc
     7501 gtcacaagcc gcatcttgtg agtcgaagac tttcgctggc cccgtaaatt tccagatact
     7561 ctcgtctaca ccggcagtct tgacaacgca accgtcctga gctatatttc ccttcaaaac
     7621 cgccagaccg ccatccttgc tgtatgcatg ttccaaatca cggatacaac cagtcgcacg
     7681 gtccgtatcg agttccttat aagacgcatt ttgtgagccg agtaccagat tgaactttcc
     7741 ggctgccgca ctggagtatt tcttgattgc ctctttacat acattagagc tggtaatact
     7801 ataccggtcg attgcctctg ccaacgtcat tccatccaca cggcggacat tcgtatcgac
     7861 caatccgccc ttggcaagct catccatgat ggcaatgatg ccaccggcac ggttaacgtc
     7921 ttgtacatga tacttttggg tattgggagc taccttgcat aagcaggggg tcttgcgaga
     7981 gagcatgtca atgtcgtcca tcttaaaatc cgctccggct tcgtgagcca cagccaacaa
     8041 atgaagtact gtattagtgg aaccgcccat cgcaatatcc agcgtcatgg cattcaaaaa
     8101 tgcctcgcga gtagcaatac tgcgcgggag tacactctca tccccttctt cataatatct
     8161 aaaggcattc gctacaatca acttagctgc atcctcaaac agtctcttgc gattttcgtg
     8221 agtggctaca atcgtgccgt taccgggcag tgccaatcca atcgcttcat tcaggcaatt
     8281 catggaatta gcggtaaaca tgcctgagca gcatccgcaa gtggggcagg catgttgctc
     8341 aatctgtgcc acctctttat cgcccacact ttcatcagca gatttaatca tagcatcaat
     8401 caaatccaaa tgttgtccgt tccattcccc ggcttccatc ggaccgcctg aaacaaacac
     8461 agtcggtata ttcagcctca tagccgccat caacatcccc ggagtaatct tgtcacagtt
     8521 actgatgcaa accatagcat ccgccttatg ggcatttacc atatactcca cactatcggc
     8581 aatgatatct cttgaaggca gggaataaag cataccgtcg tgtcccatag cgataccgtc
     8641 gtcaatggca atcgtattga actccgcagc aaaacacccc agcttttcaa tctcttcctt
     8701 tacaaactgg cctatttcgt gcaggtgtac atgtccgggg acgaattgtg taaatgaatt
     8761 gactatagcg ataatgggct tacccatctg ttccttcttc ataccattcg ccgtccacaa
     8821 tgcacgggct cccgccatgc ggcgaccttg tgtgctgaac gagctgcgta actgatgctt
     8881 cattttcaaa tctcctttta atgaaaaagc ctctcccact atagtgagaa aggcttaata
     8941 aattatcttc taacgtacga atacatacat aacctttctc acgctcttga tgccaccacc
     9001 acgacgcgaa taatatgcag gactgccagg ttaatagatg tatgtaaatt cataacttaa
     9061 ttcttctttt ttgtttcaaa cgtgctgcaa aggtaagggc ttttttataa tctccaaaca
     9121 aattgaagaa aaaaataaga taaatatgaa taatcgtaag aaaaaatcgc cctaaaatcc
     9181 tattttatca cttaacagtt ctaaatagaa ccattcagac agccaatgta aatgtattgc
     9241 caatcattga aaccatttaa taatctgaaa attaccaaag gctctctaca tcccgaaaca
     9301 aataattcgt atctttgtct cttcaaatac tcaaaaaaac agtatttact aattaaataa
     9361 agatagaaaa ttaatggaaa cagtagaaaa caagtacatc accgtagcat ataagctgta
     9421 ctcaatcgaa aacggagaaa aagatttcga agaagaagca cccgtagagc atcctttcca
     9481 gtttatctca ggtctgggaa tgacactcga accttttgaa gcccagataa aagacttgca
     9541 gataggcgat aaattcgact ttaccattcc ggcatcagaa gcttatggtg aatatgacga
     9601 cgaccatgtc attgacctcc ccaaagaaat cttcatgata gaaggagaat tcgacagcga
     9661 ccgtgtagtg gaaggcgctg tcatcccctt gatgacttct gaaggtcaac gcatcaatgg
     9721 aagtgtagta gaagtaaagg aagacgtagt tgtaatggac atgaatcatc cactcgcagg
     9781 ttgtgatttg aactttaccg gagaagtggt ggaaagccgc ccggccacga acgaagagct
     9841 tgctgaagtt gcccgtatga tgggtggcgg ttgtggtagc tgcggttgtg gtgactgtgg
     9901 cgacggatgc ggcgaccatg aatgtggagg cggatgctgc cactaaagaa ttaaaaatta
     9961 aagaattaaa aattaaagaa tcagactaca cagtattaag catgccgcat ggtaattctt
    10021 taatttttaa ttctttaatt ttcaaattct atattattta cttgtcatta tctccaatac
    10081 caatttatca gtttcattca ttcctttaga accgattttt gtcagattac ggatactttg
    10141 atccacatcc tcatcaataa taccttctac ggaagtcaca caacggtttt ccatggccat
    10201 gatggctgaa agcactgcgg ttgaaactcc ggtggttact ttcaatgcac aactgggctt
    10261 ggcaccatca caaatcattc cggtaagatt ggcaatcatg ttctgtacag catatgccac
    10321 ctgttcataa gttcctccca ttagccaagt tataccgcaa ctggaacccg tagcagcaac
    10381 cacacaaccg cataaggcag ataagcgtcc caaactctgc ttgatata
//
