LOCUS       gnlProkkaCNCIGDAG_442  15755 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CNCIGDAG_442.
ACCESSION   gnlProkkaCNCIGDAG_442
VERSION     gnlProkkaCNCIGDAG_442
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 09:45:26
            Original ID  :: gnl|Prokka|CNCIGDAG_442
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15755
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15755
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5551:5755]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5552..5755
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15755
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15755
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             3..176
                     /locus_tag="ctg442_1"
                     /transl_table=11
                     /translation="MLSVLAREGRPLRQSLQSVGEKLPLLNVRIKCMEERVLILAVFRP
                     KHWFIRLKLLPV"
     CDS             173..1354
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175:pyridine nucleotide-disulfide oxidoreductase
                     (Score: 368.6; E-value: 6.4e-112)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg442_2"
                     /sec_met_domain="Pyr_redox_2 (E-value: 4.3e-49, bitscore:
                     158.0, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDATFEERSEFYRNAISVKEAVTSALRNKNYHNLADNPNVTVYT
                     GVGSFVSSDVVSVRTSTEEIMLTSKQIIINTGAETVIPPIEGVAGNPLVYTSTSIMELT
                     ELPRRLVIVGGGYIGLEFASMYASFGSQVTVLESYPELIVREDRDIAASVKETLEKKGI
                     VFRMNAKVQSVKHIEDGALVVFSDSQTGEVVELEADAVLLATGRRPNTKDLNLEVAGVE
                     TDARGAIIVDEYLKTTQPNIRAVGDVKGGLQFTYISLDDYRIIREDLFGDKERTTNDRN
                     PVSYSVFIDPPLARIGLNEEEARKQNLDIIIKKLPVMAIPRAKTLGETDGLLKAVIDKN
                     TGKILGCMLFAPDSSEVINIVAVAMKTGQDYTFLRDFIFTHPSMSEALNDLFS"
     CDS             1869..1964
                     /locus_tag="ctg442_3"
                     /transl_table=11
                     /translation="MDDKLRLLIEEHGGYVTRKEIIGNRYLYEQI"
     CDS             2560..4071
                     /locus_tag="ctg442_4"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPALTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWELLDIQLSEDGIEEMET
                     NYEMLEIEEIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHTLTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             4112..5212
                     /locus_tag="ctg442_5"
                     /transl_table=11
                     /translation="MFSKPVKKEPNMKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGV
                     VYSLPKTQIELEIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVP
                     NSETTYFVKLKDKTVAPLMELTEDGIVKTINVPYSNSSVGKKVAPAPAVLQKKANPREF
                     LTEEILMASSTAKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEE
                     AMTQMFSGTCNKEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDL
                     KSVKMPQEDGKKKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLF
                     NKNSTIKVYFDPNTGGLLKVDREEGK"
     CDS             complement(5552..5755)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg442_6"
                     /sec_met_domain="PqqD_RRE (E-value: 6.5e-12, bitscore:
                     35.9, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.3e-18, bitscore: 56.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYES
                     RVSAYLSQMQKDGFIKLVIPVA"
     CDS             complement(6000..7310)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 85.5; E-value: 4.7e-26)"
                     /gene_kind="transport"
                     /locus_tag="ctg442_7"
                     /transl_table=11
                     /translation="MLCGYFLTDVMSPLKPMLEKELLWDSLDYGFFTSAYGWFNVFLLM
                     LIFGGIILDKMGVRFTGMGACLLMVFGCGLKYYAISTTFPEGAMLFGFKTQVTLAALGY
                     AIFGVGVEIAGITVSKIIVKWFKGKEMALAMGLEMATARIGTTLAMVLTVPLADFFGST
                     DESGTFHTNIPAPILFCLIMLCVGTIAFFLYTFYDKKLDASLDAEGLEPEEPFRMKDIV
                     YIITNKGFWLIALLCVLFYSAVFPFIKYAADLMVQKYNVDPKLAGTIPGLLPIGAIILT
                     PLFGSLYDRIGKGATLMIIGSVMLIFVHTMFALPILNIWWFATIIMIILGFAFSLVPSA
                     MWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPLLIGWVLNTYCKGPVVDGAQTYDYTL
                     PMAIFALFGVLALIVALMLKAENKKKGYGLEEANIQK"
     CDS             7325..7444
                     /locus_tag="ctg442_8"
                     /transl_table=11
                     /translation="MLEHSIGVRRSHSISVSNVLSLLYLKIVVNNLHTTNKGS"
     CDS             complement(7638..8033)
                     /locus_tag="ctg442_9"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPAAETPAPAAE"
     CDS             complement(8040..8813)
                     /locus_tag="ctg442_10"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTAPEEVTARTSFDYSMDYTSYLLEETPATEQPAEETPKLKGYELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETIKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             8849..9313
                     /locus_tag="ctg442_11"
                     /transl_table=11
                     /translation="MVGDLFRHFSNQSVLYGSQQLARVVGTERRKLLFKVFGMIGVVDK
                     TYIDGNSQLRLRRVTVGRYCLVVLIVSCDFSVNLQVRILIRLEQLQTGLPDEDIFQVLI
                     EFGCQRSIYILRLDREVGYRNGLYLIIIDRRSVKLIGNSARNDYQRQAEQ"
     CDS             complement(9333..10574)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.2; E-value:
                     2.3e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg442_12"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(10584..11678)
                     /locus_tag="ctg442_13"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQANFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(11683..11997)
                     /locus_tag="ctg442_14"
                     /transl_table=11
                     /translation="MSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYVSHTRLD
                     EKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQKQIPLGEASKEAEQTNK
                     "
     CDS             complement(12742..13776)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg442_15"
                     /sec_met_domain="PF04055 (E-value: 3.6e-18, bitscore: 57.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYPLLGMTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDD
                     MTNLSLKHRELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATL
                     CVSSQVGCKMNCKFCMTGKQGYTANLTASQIINQIHSLPERDKLTNVVMMGMGEPLDNL
                     DEVLKALELLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAE
                     LMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRV
                     NLIRFHAIPGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEK
                     NNES"
ORIGIN
        1 tattattatc ggttttggca agggagggaa gacccttgcg gcagagtttg caaagcgtgg
       61 gcgaaaagtt gccattgttg aacgttcgga taaaatgtat ggaggaacgt gtattaatat
      121 tggctgtatt ccgaccaaaa cattggttca tcaggctaaa attgcttccg gtatgaaaga
      181 cgctacattt gaagaaagga gtgagttcta tcgcaatgcc atttctgtga aagaggctgt
      241 gacaagtgca ttgagaaata agaattacca taatctggca gataatccca atgtaacagt
      301 ctatacaggt gtgggctctt ttgtctcttc cgatgtggtt tctgtccgta catctactga
      361 agaaataatg ctgacatcga agcaaattat tatcaatacg ggggcagaaa ctgttattcc
      421 tcccattgag ggagttgcgg gtaatccgtt ggtttataca agtacctcaa tcatggaatt
      481 gaccgagctt ccccgccggc tggttattgt cggtggcggt tacatcggtt tggagtttgc
      541 gtctatgtat gcttcgttcg gttcacaggt gaccgtactc gaaagttatc ctgaactgat
      601 tgtgcgtgaa gaccgggata ttgctgcaag tgtaaaagaa acattagaga aaaaaggcat
      661 tgtttttcga atgaatgcaa aggttcaatc tgtgaaacat attgaagatg gagcactcgt
      721 tgttttctct gattcacaaa ctggcgaggt ggtggaactt gaagctgatg ctgtattgct
      781 ggcgacagga cgccgaccga acacgaaaga tctgaatttg gaagttgccg gagtggagac
      841 ggatgcacgc ggagcgatca ttgtggatga atatctgaaa acaacccaac cgaatatacg
      901 tgccgttggt gatgtgaaag gtggtttgca gttcacttat atttcattgg atgattaccg
      961 gattatccgg gaggatctgt ttggcgataa agaacggaca acgaatgatc gcaatccggt
     1021 tagctactct gtttttattg atcctccatt agcacgtatc ggattgaatg aagaagaggc
     1081 tcgtaagcag aatttggata ttattatcaa gaaattgccc gttatggcga taccaagagc
     1141 gaaaacattg ggagaaacgg atggcctttt gaaagctgtt attgataaga atacgggaaa
     1201 aatattgggc tgtatgctgt ttgcgcctga ttccagcgaa gtaatcaata tagttgctgt
     1261 tgcaatgaag acaggtcagg attatacttt cctgcgtgac ttcattttta ctcatcctag
     1321 tatgagcgag gcgttaaatg atttgttttc atagtagtaa gaatgagtat aatcttcctc
     1381 tataaagttt aaaaaacatc aaagtatctg ccacctgcaa caaaacgctt gtaatgtatt
     1441 agtaaatagg cagttggagc gttgcagata cctgttgcag atacgttgca gataaagtat
     1501 ctgcaacgca taatataact aaagaaaagt ccttgatttc tttatgcaaa gctatgggaa
     1561 gttcatggta tccctataag gagactgcag tatctacgta cggaaactgc ggtatccata
     1621 catggacact gtcgtttcct gccttggaca ctgtcgtttc ctacggtggg aactggagtt
     1681 tcttgcctcg gaactgtagt ttcttatgct ggaaactgaa gtttgcttgc ttggaactat
     1741 aatttctttt gcttgaaaaa tagttaagtc atgctcctac tcacttttgt atcaaaagaa
     1801 aatatgtaca aaactacggc acttagaaat aaatgccgta tatttgtaca taataagaca
     1861 agtgtgatat ggatgataaa ttgagacttc tgatagaaga acatggagga tatgtcaccc
     1921 gtaaagagat tatcggtaac cgttatctgt atgaacaaat ctaattgctt gaaacatatt
     1981 gctttaagct tgtgagcaaa gtcttctaat tatagaatta agaagttcga ctaaaatcaa
     2041 gacgcttatg acaaggtatg agggtaaaag ttactctcat cttactctca tgcttactct
     2101 catacctgta actccgatga ataaaggctt ttcaaacgat tgatgagagt atgagagtaa
     2161 aattgcttat ttatttggtt cttcgtcaaa tttggtggta agtttttctc cgctcattta
     2221 gctaattcag tcagtgccta tattttctta tgaaagtgag taaaaaggga taattattaa
     2281 cttggaaata aagagataaa gaatttacca ccaaatttga cgaagaacca gaaatctttt
     2341 tcaggagaaa taaaagtaag ttcataatgg tgctgcattg aattattttt tggcggagtt
     2401 attctaacac ttaatagttc aaaagcagat atttctctga cccaaagata gaactaatga
     2461 tgaattaaaa gttgcaatta tggttttctt cccacaacaa acgggaaaag tcagaagaat
     2521 catgtacatt tgtaatccga aaactaaaag aacatcgcaa tgaaaatatt tccaagcagc
     2581 agtatcaaga aattggacgc ttataccatt gagaacgaac ctattgcatc aatcgatctg
     2641 atggaacgtg cagcaaccgt attaacaaaa gccatcacag acagatggaa tacggaaacg
     2701 ccggtcacta tctttgccgg accggggaat aatggcggag acgctctcgc cgtagcccgc
     2761 atgatggctg aaaaaggata taaaatcgag gtatttctct tcaacacgaa aggagaactt
     2821 tcacccgact gccagaccaa taaagaactg gtagaaatga tggaagaagt aaaattccac
     2881 gagatcagta cccaattcgt acctcccgcc ctgacgcccg accatctggt aatcgacgga
     2941 ttattcggtt caggcctgaa caaaccgtta agcggcggat tcgctgccgt agtgaaatac
     3001 atcaattcct cccctgctat ggtagtagcc atcgacattc cttccggact gatgggagaa
     3061 gaaaatacat tcaacgtaaa agctaatatt atccgcgccg acgtaacttt cagtctgcaa
     3121 ctgccgaagc tcgcctttct tttcgcagaa aacacagaat ttgtcggaga atgggaattg
     3181 ttggatatcc aattgagcga agacggtatt gaagagatgg agactaacta cgaaatgttg
     3241 gaaatagaag aaatccgttc actcatcaag ccacgcaaac agtttgccca caagggaaac
     3301 ttcggtcatg cactattgat tgccggttca aaaggaatgg caggagcctc tgttctcgct
     3361 gcccgtgcct gcctccgttc gggagtaggg ttgctgactg ttcatgcacc aatgtgcaac
     3421 aacgacatct tgcagacctc catacccgaa gcaatcgtag aaaccgacat caacgaaacc
     3481 tgttttgccg tacctaccga cacggacgac tatcaagcag tcggcatcgg tccgggactg
     3541 ggacgaaacg aggaaacgga agctgcctta ttggagcaac tggaacattg ccagactcct
     3601 gttgtagtgg atgccgacgc acttaatatc cttgccaacc accgccatac ccttacccac
     3661 ctgccgaagg gttccatcct caccccgcat ccgaaagaac tggaacgtct gaccggcaaa
     3721 tgccaagact cttacgaacg tctgatgaag gcttgcgaat tggctcgtgc cgcccatgtt
     3781 cacattattt taaaaggagc ctattccgcc attatcaccc cagaaggtaa atgtttcttc
     3841 aacccaaccg gaaatccggg aatggcaacc ggaggtagcg gtgacgtact gaccggagta
     3901 atcctggcac tgcttgccca aggttatccc accgaagaag ccgctaaaat cggcacttac
     3961 attcacggat tggcgggcga tgtcgctcaa aagaagcaag gaatgatcgg aatgatcgca
     4021 agcgatatta tcacctgtct gccgacagca tggcgacttg taagcgaata aaagttaaga
     4081 acttacagtt ttttcaataa cttcattaac tttgttttca aaaccagtta aaaaagaacc
     4141 gaatatgaaa aagttaatta tagcagcagg actacttatg acaacgtccg cctatgcaca
     4201 aaccgaagta ctgacagggg ttacccgagg aaaagactat ggagtggttt acagtcttcc
     4261 caaaacccaa atagaacttg aaataaaagc caacaaagtc aactatactc cgggagaatt
     4321 cagcaaatat gctgatcgtt acctgcgact gaccaacgtc tccgccgatc ctgaagagta
     4381 ctgggaactg gctagcgtaa aagtgaaatc cgtaggtgtg cccaacagcg aaactacgta
     4441 tttcgtaaaa ttgaaggata agacagtagc accgcttatg gaactgacag aggatggcat
     4501 tgtgaaaacg atcaatgttc cttacagcaa tagcagtgta ggcaaaaaag ttgctcccgc
     4561 tcccgcagtc ctccaaaaga aagcgaatcc tcgcgaattc ctgaccgagg agattctgat
     4621 ggctagctct accgccaaga tggccgagct ggtggctaaa gaaatctata acatccgcga
     4681 aagcaaaaat gccttattgc gcggacaggc tgacaatatg ccttcagacg gagcacagct
     4741 taagattatg ctcgacaatc tgaatgcaca ggaagaagcc atgacgcaaa tgttctccgg
     4801 cacctgcaac aaagaagaaa gaacattcac tgtccgcctt acccctgaca aggaattcaa
     4861 caatgaagtt gctttccgct tctcgaagaa gttaggtgta gttgccaaca atgatttggc
     4921 aggaactccg ttttatatca gtctgaaaga cctgaaatct gtcaagatgc cacaggaaga
     4981 cggtaagaag aagaaagatt tggatggaat cgcctacaac gtacccggac aagctatggt
     5041 tacactgacc gacggtaaaa agaaacttta cgaaggtgag cttcctatta ctcaattcgg
     5101 tgtgatagaa tatctggctc cggttttgtt caataagaat tctaccatca aagtttattt
     5161 tgatccgaat acgggaggat tgctcaaagt ggacagagaa gaagggaaat agaaaaacaa
     5221 ggaagtgaac ttctaaaaaa caaagaatat ggttggtgaa ggacatgcat tcgacatgat
     5281 acgccgaata aaagagggac gggaagcttc ccgcctacgt cgtgaacgtg ctaacgataa
     5341 gttgaagcat ctaaaccgtg caaacgaacc ttatccacta cccaacacca ctcccgaaga
     5401 aatggaacgt atcatccacg actcggagaa aaagaaagag aaagacagca attattttgt
     5461 ttggggaacg cttattatca tgggggtcct gatagcaatt gccgtcatac tttgggctgt
     5521 atttatcaaa taaataataa taagttccta tttatgcgac tggtatcacc agttttataa
     5581 atccatcttt ctgcatttga gaaagataag ccgatacacg cgactcgtag ccctcttcat
     5641 tttgaaagtg gtctgcgagt ttttctataa tctcacgaac attgcgtttt ccatctatca
     5701 gttcccatac agccgtaccg tgttcttcca atttcacatg aagttctttc gacattcctt
     5761 tcggcacaag gaagcgttgc atccacggat atttaaaacg gggaaaggag agcacaattg
     5821 tctccccttc cctttctgct gtaatatgtt cactgcgaca gggaatgacc tctaacaggt
     5881 tgattttctc tttggcagcc atacttctta ttttttattt cagagtattc atactgatac
     5941 ccttttgttt acaccttgat acaaaattcc tttgttactt taggtattga atttcctagt
     6001 tacttttgga tattcgcctc ttccagaccg tatcccttct tcttgttctc tgccttcaac
     6061 atcaaagcca caatcagagc aagcacacca aagagagcaa aaatagccat cggcaacgtg
     6121 tagtcataag tctgtgcacc gtctactacc ggacctttgc aataagtatt caacacccat
     6181 ccgatcaaca aaggaacacc catcaatccc cagttctgta cccagaaaat caatgcgtat
     6241 gcggtaccca actgtttttc cggaataatc ttcggaacag acggccacat agctgaaggc
     6301 accaacgaga aggcaaatcc caatataatc atgatgatag tagcaaacca ccatatattc
     6361 agtataggca gagcgaacat cgtatgcaca aaaataagca tcactgatcc gattatcatc
     6421 aacgtagctc ccttaccgat acggtcataa agcgagccga acaacggagt caggataatc
     6481 gcaccaatcg gcaacaatcc gggaatcgtt cccgccaact tcggatctac attatacttc
     6541 tgcaccatca agtcggcagc atacttgata aaggggaata cagccgagta gaacaataca
     6601 catagtaatg caatcaacca gaatccttta ttggtaatga tatacacaat atctttcata
     6661 cggaacggct cttccggctc caatccctct gcatccaaag aagcatccaa cttcttatca
     6721 tagaaagtat aaaggaagaa agcaatcgta cccacgcaca acataatcag acaaaacaga
     6781 ataggagcag gaatattggt atggaatgtg ccactctcat ccgtagatcc gaaaaagtcg
     6841 gccaaaggaa ccgtaagcac cattgccaga gttgttccga tacgtgccgt agccatttca
     6901 agtcccatag ccaatgccat ttccttaccc ttgaaccatt ttacgataat cttggaaact
     6961 gtgataccgg caatttccac acctacaccg aagatagcat accccaatgc agccagggtt
     7021 acctgtgttt tgaatccgaa gagcatggca ccttccggaa aagtagtaga aatcgcatag
     7081 tatttcaatc cacaaccaaa caccatcaat aagcaagccc ccattccggt gaaacgaact
     7141 cccatcttat ccaaaatgat accaccgaag atcagcatca acaggaatac attaaaccac
     7201 ccgtaagcgc ttgtgaagaa accataatcc agactgtccc atagtagttc tttctcaagc
     7261 atgggtttta gaggagacat tacgtcggtg aggaaatagc cgcatagcat agtaaatgcg
     7321 actaatgcta gaacactcca tcggagtacg gcggagtcat tcaatttctg tttcaaatgt
     7381 tctgtcattg ttatatttaa aaatagtagt taataatctt catacgacca acaaaggtag
     7441 ttaaatctcg tttgtttcta tcaaaaagag attgttttta caagaaaaag ttaagtgcgg
     7501 attacactga ccacgcggaa gattgaaaat ccgtgtaatc tgcgtaatcc gcacttaaat
     7561 atcaaagaaa tgcagcattc gtctgcacct tcccattaat ggttttaccc caaagtctta
     7621 cctgacgaca gagtgaatta ctctgctgca ggagcaggag tttcagcagc cggtgccgga
     7681 gtttctgtag caggtgcatt ggtagcagga gcttcagttt gcggcgcagc cgtacctgcg
     7741 ggtaagttat acgggttagt ctgttgttct ttctgtgcct gttccaacac tgcgtcttta
     7801 gcaacagcag agcgaggaac tacataagca gtagcaatgc tcattaccac catgaagata
     7861 gctaagcccc atgttgcttt ttccagaaaa tctgtagtct tgcgcacgcc catgatggcg
     7921 ttagatgaag agaaaccaga agcaagtccg cctccttttg agttctgaat cagcacgatg
     7981 aaacacatca acaaggctgc aataaccatt aagataacga ataataagta catttttagt
     8041 tattttgaat tagcgttaat aatcaatttc tccaaaaatc tgatttggtc tgcaaagtaa
     8101 gcattttttt ttggatattt caagcttaat tttttaatta tttcaagagc ttttgaatat
     8161 cgttgctgtt taacatagat ttttgccaaa gtttccgtaa aacagctgtc atcttcctct
     8221 tcttccttta tcgtttcttc ttcggtaagt tcgtccgaag aggttggcga agatggcatt
     8281 tcttctctta aaggtttcat gcagagggga gagtcgctct cgctcttttc tataaagtcg
     8341 tcaatcagtt cgtagccttt gagtttgggc gtttcttcgg ccggctgttc cgtggccgga
     8401 gtctcctcca aaagataaga ggtgtaatcc atcgaatagt cgaagctggt gcgggcagtc
     8461 acttcttcgg gggctgtgga caagaaagcg tcgatcaatg ctaatgtgcg gtctacagat
     8521 ggttcgtctt tcagtacctc cgtgagaggt actccctttt tccgtgcttg cacatcatag
     8581 cggtcacctt caatcaaccg gaacaactgc cgtctgtctg caatgtaaag aactgctttc
     8641 cgcagttctc caccgaaact aatatcatgg agaatataca gattcttcag atacagcaga
     8701 cgaagtgact gaaaatacgg atacctcgca agaagattgc gcagttcgta caaagtatcc
     8761 ctattcagcg tctcgggatg ctgaatccat tgttgaaagt taacagaagt catttatatt
     8821 accagtttgc tacagttgca ttaaaaattt ggtcggtgat ctctttagac atttcagcaa
     8881 tcaatccgtc ctgtacggca gtcagcaact ggctagagtc gtaggtacgg aacgcagaaa
     8941 actgttgttc aaagtcttcg gcatgattgg tgttgttgac aaaacgtaca ttgacggtaa
     9001 tagtcaactt cgtctccgaa gagtaaccgt cggcagatac tgcctggttg tactgattgt
     9061 atcctgtgat ttctccgtca atctgcaagt ccgcattctg attcggcttg agcagttgca
     9121 gacgggtctg ccggatgaag atatctttca ggtcctcatt gaatttggtt gccaacggag
     9181 catatacata ctccgacttg atcgggaagt cggctatcga aatggtcttt accttatcat
     9241 aattgataga cgatccgtta aacttatagg aaacagtgca cgcaatgact accaacggca
     9301 agccgaacag taacaaaggg cgtattattt tcttaatcca attcatattc ttttattttt
     9361 ctataaagtg tacgctcgga aatattcaag tccttggccg cactcttccg ctttccatga
     9421 tgcctctcaa gtgccttgcg tatcatttct ttctccactt cgtccagtga caaaggagat
     9481 tcttctacat attcttccgt gtcttgtatg tcatcatcat ccttgcaaac cgtaggctgc
     9541 atggtgtgaa taatagcagg taccgaaggt tgatgcgccg tcactaccgg agtagtaacc
     9601 accgttccca tttgtcctac ctgccccacc tgtccggcac gttccgccat caggttgtgc
     9661 accatcttct tcagctccgc cacttcctgg cgcatatcga acagaacgga ataaagaatc
     9721 tcccgttcgc tctcaaagcc tttactctca cgcgttccca tcagcgcggg aagacgttgc
     9781 gtattttgtg cgggaagata attctgcaag atagcagcag agatctccct attggtttca
     9841 atgatagata tttgctcggt gatgttcttc aactgacgca cgtttccggg ccacgggtaa
     9901 gctaacaact ctttcttcgc atcctccgtc aactgaatag caggcatccg atatttctct
     9961 gcaaagtctg cggaaaactt acggaacaac aaaagtacat cgtcaccacg ttcacgcaaa
    10021 ggcggtattt ggataggcac cgtattcaac cggtaatata aatcttcacg gaaacgtcct
    10081 tctgcaatcg cttgtgtcag attgacgttg gtagctgcca ccacacgcac atccgttttt
    10141 tgtactttgg acgaacctac tttcataaac tcgccactct ccagtacacg gagcaaacgt
    10201 gcctgggtag acatcggcaa ctcccctact tcatcaagaa aaatagtacc accgtcagct
    10261 tcgccaaagt accctttccg ttcgccaatc gcaccggtaa acgcaccttt ctcatgtccg
    10321 aacagttcgg aatcaatcgt gccctccgga atagcaccac agttgacagc aatatactgt
    10381 ccgtgcttcc tccggctata ttgatgaata atctgcggaa aactttcttt tccgactcca
    10441 ctttctccgg taatcagcac agacaaatcg gtaggagcta cctgaatggc aacatctatg
    10501 gcgcgcgaca atgcttcagt atttccaata ataccaaaac gctgtttcac ttgttgtatc
    10561 tctgctttcg tcatcactcg tttttaatct tcgtctactg tatccagctt cagtttatca
    10621 ctatcgtcac gtttctcgta atactgttta cgcaacggat tggcacgagc cactttttca
    10681 cgctgacgat tacggaacac gtcgatggca acatagattg cctggcggaa agaatcttca
    10741 caagccactc ccttgcctgc aatatcgtat gccgttccat gagccggaga agtacgtacc
    10801 accggcaggc ctgccgtata gttcaccccg tcttccatag ccaaggcctt gaacggagcc
    10861 agcccctgat cgtgatacat cgccaggata ccgtcaaaat gagtataatt gcctgaaccc
    10921 ataaagccgt cggccgcata aggaccgtag caaaggattc ctttctcttc catttctttc
    10981 atggcaggga taatcacttc ctgctcttcc attcccaaca aaccaccgtc tccggcatga
    11041 ggattgagag agagcaccgc aatacgcgga gcgccgatac cgaaatcctg tttcagacaa
    11101 cgatggaata tcatcagttt ctcctgaatc agttctttgg taatcgtagt cgcgatctct
    11161 ctgacaggga tatgtgtagt caccaaagcc acccggaagt cattcttcat caaaatcatc
    11221 aatgacttat caccattgcc cagacgttct tcgatatatt ccgtatgtcc ggggaaggag
    11281 aactcttccg actgaatcgt atgtttgttg atcggagctg ttacgataac gtctatcaac
    11341 ccttcgcgat attcttcgat ggcacgttcc aaagccccca gcgcagcttt accggcttcg
    11401 gggtcgggtt tggaaaattc cactttcacc tcatcatccg tacagttcac cacgctcaaa
    11461 cggttgtacc ccgcttcggt agcagagttg acaatgctga aattggcctg tatatccagc
    11521 gctttgcgat gataagccgc tactttcggt gagccataaa tgatcggagt acatagttcc
    11581 aacatcgtag ggtcggaaaa tgtcttaaga atcacctcat agcccacccc gttaatatct
    11641 ccttgggtga tacctatcct tatcttgtta tcttccatgt ttttatttat tagtttgttc
    11701 cgcttcctta gatgcttctc ccaatggaat ctgcttctgc tgaacttcat tcggaagttt
    11761 cagtgtatac agagatgctt ccatctggcg taccaggttg cgtttcattt tatcaggtga
    11821 ataaacaaat atttctgcag taataattcg ttggttcttc tcgtccagac gagtatgaga
    11881 tacatacgga ccacccataa agtcgccctt catacgccac agaccacgtg cttccattgt
    11941 gtagctgttc tgcacattga tcggacggac atcggtcagc aaactatcgg tcgacatata
    12001 aacgccttcc ttgaatccgg ggatattggc tttcatcacg gagtcacgtt tgtgcacaaa
    12061 atattctttg gtaaacgtat ccttgtcagt gtacggataa gagtacatca caaagttacg
    12121 gtcggcacta cctgtgttgg tagaagccca gaagaaatca tccccggtct ttgaattagc
    12181 cagttcggca tccacccaga tgtcgcatcc gaacaaactg tccactttct gcgaaatgaa
    12241 attactgtgt ttcccttcca ggaatgtaat ctgacggttc atttccgcac gggtaaagaa
    12301 gtcgacaatc gtctttttgt tctcttccac aaacttctca aactcttctt cgttcggagc
    12361 ctggatagtc aatatcatct gcggattggc atacacgtcc ttcgcatatt tgaacgaggc
    12421 tttcgtatat atatcctgta tatctacaat aataatgtta cgtatcaact tcagcgtaga
    12481 atcataatct ttcggcgaag tatacataat ccggaaagaa ggttccgact gcggcaaacc
    12541 gggcatatca gcatcgagcg catcatgtaa agcccttccg gcagcacgat cccaaacacc
    12601 gtgatctact acaaccaaaa gctcgtaagc acgaccacta gaggtgtgat ttcctttcag
    12661 accacaagat gcaacgacaa aggctaccaa agcgatgcat aaaataaaag agtacttttt
    12721 catgatgttc ggttttatat attaactttc attatttttc tcctgtttcg ctgtcgacag
    12781 cataccgcaa gcggcaaaaa tatcttcgcc tctggatgaa cggatagtgg tgaaaagtcc
    12841 gtgtgacgtc agataatcac gaaaacgggt catcgtatcc atgtccgccc cctcgaggtc
    12901 tacccccggt atggcatgaa aacgaatcag attcaccctg caatccagcc cgcgaagaag
    12961 tttcagcaac tctttggcat agacctgcga atcattgagc cctttaaaaa caatatattc
    13021 aaacgaaagt cgacgttgtt tactaaaatc atagtttttt aacagttcca ccatttcggt
    13081 gattgaaaac gccttttccg ccggcattaa ttcagcacgc tgaacggtca gcggcgagtg
    13141 aaggctgatg gcaaggtgac agtcattttc ttcgataaaa cgctgcaatc ctttccgtag
    13201 cccgacagta gaaagcgtga tacgcttcgg actccatgcg taaccgtagg tagcggtcag
    13261 tagttccaat gccttcaata cctcatccag attatcgagc ggctcgccca ttcccatcat
    13321 tacgacatta gtcagtttgt cccgttccgg cagcgaatga atctggttta tgatctggct
    13381 ggcggtcagg ttagctgtat acccctgttt gccggtcata cagaacttac agttcatctt
    13441 gcaacctact tgtgacgaca cgcacaacgt tgcccggtca tcatccggta tataaaccga
    13501 ctctacaaaa tggttctcac ccactttata aagatacttc accgtaccat ctacagagcg
    13561 catttcatct accggagctt ccgctcccac ctcatagttc tgcttgagca actcccggtg
    13621 tttcaatgac aaattagtca tatcatcaat cgaggctacc ttcttttcgt aaagccagga
    13681 tgcaatctgc ttggcagcaa agccgggcat acccagtctt tttgtcaatg attgaagctc
    13741 tacaagagtc attcctaaaa ggggatattt agacattctt ctttctgttg atagtttata
    13801 tctgcaaatg taaggaaata aagtcgattt ccgtatagca ggaatgtaaa agttaacaaa
    13861 aaagggaagt atgcctccgt tatgattcaa ccacgctgat atattgaagt agcttttgcg
    13921 ccatttcaga atcctcgcca ttctttttca cttcatgacc gtacgcctca cggaaacaag
    13981 ccaacgcctc ttcccgttca ttacaaaagc tgtgcaaaac ccctaagttc tgacaagcca
    14041 gaatcgtatc ttcttcctcc catcccaaat acttctttcg caattcaagt tctctgaaga
    14101 aagcctcttt cgccattgga taattctcca acttcacata agcctgtgct ttgtaataat
    14161 ataccagaca ggaagcatta gggtcagcat catcgtgaat atccaaagac gtcgcaatac
    14221 gaatcacgtt atcatagttt ttattcatgt aatactgctg cataatatca catctcaatg
    14281 cctcgtagcg gacagtcagt tccgccagac gcggtttttc gctgaaatac atttcatgca
    14341 gaagagactc acggaaaaat aaagtagacg cctgctcatc gccacgttca ttcatcatcc
    14401 gtttgaattc cctgcataga taatacaact gtttatgaca agcgacgatc tgttttttgc
    14461 tgtctatctg tatagcaatg tccaacgcct gattcatcag catccatgct tcatcgtatc
    14521 gtttgatata ataaagacat ttaccctgca tacgcaaaca tttagccact ccaccggaca
    14581 gtctgccatt caatgactcg tgcatttcag ctactttccg gaatttctcg gcagcactct
    14641 cttcctcatc cttatagtaa tcacaataag ccagatattc ggaaagttca atgacttctg
    14701 cctgactctt ctcgtcagca gaagccgcat gataatcaag cgccctattc aaataggtca
    14761 ctgcttcatt gtattgctca ttgtagtaat atgccagagc tagatttcgg caggtgttgg
    14821 caatctccag ttccggagtc ggtacaatgt tttcctgcat caccaatgct ttcaagaaac
    14881 agtcgcatgc cgtttcgtac tcttcattac gggcatagcg gcatccctca ttcatcttca
    14941 ataccgactt ggcaatgagt ggcatggcag caccttccat actcttctca ctcacagcag
    15001 ctgccgcctt cgtcagatgg aaagaactgc tcaagaaagt agccatatca ttagcaatga
    15061 caggaattaa aaaagaatcg atctcatcaa agtccaattc ggcatagact tcaggcgtaa
    15121 cttcaggatt gtcgttcatg atcgccttcc agctatcttc caacagagaa cgattcgtgc
    15181 gatacagaat ctcgaaaatc tccacatcac aaatccaatc cttcaatata tcccattctt
    15241 gcatcttata gcattgatag gtaatctcca ctttatagcg atacgaatca tggtagcaga
    15301 actgtttcat gcgatagtta taatcggcaa aagtcaacgg atgagaaagg atctcttcct
    15361 catccagcaa agcggaaata atttcatggc gactatcatc tatacattcg tcatcttgag
    15421 cgaaatagcg ttcgatcgcc tctaccattt gtgtgtcacc aatgcaatat cgccctcctt
    15481 tgttggtgag ccagctgctc atttccactc tcaactgcga ccaaagtatc tgattaatgt
    15541 ctgccatact cttcacttca tcttcggtaa atccttctaa agtaagtgaa agcatcagaa
    15601 gcgttcttcc aatctcttcg aaaccataat cagccgacaa acgccgtaac acactgtcat
    15661 agaattgccc aacctcattg agccggcaat atccactcat atattcattg agagcatcgt
    15721 actgaccgaa cgaaaccagc tcgttgagca ataca
//
