LOCUS       gnlProkkaJNNJMPNM_59   10962 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JNNJMPNM_59.
ACCESSION   gnlProkkaJNNJMPNM_59
VERSION     gnlProkkaJNNJMPNM_59
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 10:21:46
            Original ID  :: gnl|Prokka|JNNJMPNM_59
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10962
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10962
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1648:5962]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1649..5962
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10962
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10962
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             3..422
                     /locus_tag="ctg59_1"
                     /transl_table=11
                     /translation="MVGIDLEKALSNPKSNADLVLREGDVISIPKNTNTVTINGAVMVP
                     NTVSYMKGKDVDYYLNQAGGYSDNARKSKKFIVYMNGQVTKVKGSGKKQIEPGCEIIVP
                     GKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             437..1585
                     /locus_tag="ctg59_2"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             1649..2368
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg59_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.2e-17, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2389..3690
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 209;
                     E-value: 1.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg59_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.3e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 9.7e-122, bitscore:
                     395.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.2e-63, bitscore:
                     204.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             3707..4831
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg59_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4841..5962
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg59_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg59_6"
                     /sec_met_domain="Aminotran_5 (E-value: 1.8e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4931..5938
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg59_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg59_6_Aminotran_5.1"
                     /locus_tag="ctg59_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             5959..6432
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 73.7;
                     E-value: 2.7e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg59_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAVLYPYKKAPVVI
                     GDNVWIGANVTILPGVTIGDYVVVAAGAVVTKDVPSGVLVAGVPAIVKKRFNK"
     CDS             6429..7874
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg59_8"
                     /sec_met_domain="Polysacc_synt (E-value: 9.6e-33, bitscore:
                     103.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKTSLKNKAICGIFWSAVERFLSQGIQFVVTVIMARFLLPSDY
                     GMVGMLAIVLQLSQTLMDSGFTNALIRYKERTEIDYSTVFFFNILASLVIYFLIFFLAP
                     YISWFYKIGQLVEITRILSIVIVLNSFAIIPKTKLIIAVDFKTQSKVSFIAALVSGIIG
                     IWAAYLDFGVWALVGQTLVNGLLIVVLYAYFCRWKPLWIFSLKSFRLLFAFGSKLVLAN
                     ILNTLYKNLYAIVIGKKFSSVDLGFYTRAEQFAQFPSYNLSAIISRVTYPILSLVQNDN
                     DRLSALYRKYVRLSSAFIFPLMILLIVIAQPLVLLLLTEKWIGVVVLLQILCLDWMFDH
                     LSSINLNLLYVKGRSDLALRLEVIKKVLATGILLLSIPWGIVGMCWGRVMYSLIAVYLN
                     TYYTESLIKLSLIRQMRDILPSFFLALIMGGGTWYMILLLEGEIVQIVVGSVIALLLYG
                     TLLYCFSRSLFDEIWAVILKIKR"
     CDS             7874..8596
                     /locus_tag="ctg59_9"
                     /transl_table=11
                     /translation="MDKLSLIISKIRRNHWYRTYMRPIYLFVYGNRKLKNRNRIFLQYS
                     QELLTNFHQAMNEVGIPYWLEFGTLLGAVREHSFISHDFDLDVGLFKEDYSDIIREVLK
                     KYGFKRIRCITALDFIDAYEETYLYKGVTIDLFLFSREKNCDGVYCYDFVPVYSDIKRT
                     KKGDNAIRRIHFPRIDLIEYSFIGINTFVPENYEEHLCMHYGKDYMIPNPHWKDSDAQH
                     TDIFYGREIRIELFDKSK"
     CDS             8610..9623
                     /locus_tag="ctg59_10"
                     /transl_table=11
                     /translation="MFYLFFLLIVLFLLYIQSRKRQYSTVAGICVPIIIIFVVICRYRV
                     GYDYLTYYTLIENEEEAQILYLFSPLSIVWAEIALYFESPQMLFVLFGLPTFALLIFTL
                     KKYSKDYALSVTILICFFFFTSLSIIRQALALAICFYGYRFIVKRSLIKYILCILIAAL
                     FHPSAGVAIIIYWLPFLKFRLVVLLSIISIVAKPLFFYMLNILGVYTSYLDGKMDIEGG
                     KYTQLIYFLLFIICFVLGSKNIDKNKCNLFNVLLLSFVFVSFLGAHLGGRIAFYFNIYY
                     CLLIPKVVKGLDGQLREQVKLLSYFLCISYFLLYLFVPFIKGVPSYYIPYKFIFFK"
     CDS             9628..10587
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 57.2; E-value: 3.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg59_11"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.2e-42,
                     bitscore: 135.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLISIIVPCYNSERYLSDCLLSILNQTYVNWEVICIDDGSQDNTL
                     SILNHYATLDERFKIISQSNAGVSVARNKALSQCQGEYICFVDSDDLIEPNFLITLLQL
                     ISHQADLAICGFTRSMVFCMDDAQGYIEMSGKRCIERIILDKSFNPQICCMLFRHNIIK
                     EKQLEFVIGCTRGEDREFILKYLVYSNKVCYTNNLLYHYRVNDQSAMAIFSIKSLTSIE
                     ASQRTVNYYKKVNYSVRGLEFEFSRTLWKFMILAILSGQNDLYQIIREKYDLKRQMEHL
                     YSHPGLSEKLTARLFVWNEALFKWVFSIIRYLYKKRWR"
ORIGIN
        1 ttacggttgg aatagatttg gaaaaagcct tgagcaatcc taaaagtaat gccgatcttg
       61 tcttacgtga aggtgatgtg atctccatac ctaagaatac taatactgta actatcaatg
      121 gtgctgttat ggtccccaat acggtttctt atatgaaggg aaaggatgtg gattattacc
      181 tgaatcaggc cggtggctat tctgataatg caaggaagag taagaagttc attgtttaca
      241 tgaatggtca ggtgacgaag gttaagggta gtggtaagaa acagattgag ccggggtgtg
      301 agattattgt gcctggtaag gctaagaaga aagggaacat agctaatatt ttaggttatg
      361 ctacttcctt cagttctttg ggtatgatga ttgcttctat tgctaatctt ataaagaaat
      421 aatagaattt acttttatgt cagaacaacg acaggataaa aacttgctct ctgaaccaca
      481 caagacagaa agtgatgaga tagaaattga tttggtcgat atctttcgca agattattgc
      541 tattcgtaaa aaattataca aagccgttgg aattggtttt attattggaa taattgtagc
      601 ggtaagtatc cctaaacagt atacagtaaa ggttaccctt tctcctgaaa tgggtaatgc
      661 gaaggggagt aatggtttag ccggacttgc tgcctcgttt ttaggagatg gggctctaat
      721 aggggaaagc acagatgcct tgaacgcttc tctttcagca gatattgttt cttcaactcc
      781 ttttttattg gaacttttag aaatggaagt ctccgtttct aaaaaggatg ataaaatgac
      841 tttggggtct tatctcgatg aagagtcatc tccttggtgg gattatctta taggttttcc
      901 gggcatagta ataggaggag ttaaatcatt attcggagaa gatacggttc ctgccagtgg
      961 agggcggcaa ggaactatcg aattgacgaa agaagtaaat gagaagatta attttcttaa
     1021 aaagaagatt agtgcatcca ttgataagaa aaccgccata acgagcatta cggtcacctt
     1081 acaaaatccg cagatcactg cggttatagc agattctgtc gttcataaat tacaggaata
     1141 tattattggg tatcgaactt caaaagtaaa agaagactgt gcgtatttgg aacggttgtt
     1201 taaagaacgt cagcaggaat attatgctgc tcaaagaaaa tatgcggatt atgtagacgc
     1261 ccatgataat gtggttcttc aaagtgtacg tgctgagcag gagcgtttac agaacgacat
     1321 gagtttggct tatcagatat atagtcaggt tgctaatcag ttgcaggtat ccagagccaa
     1381 agtacaggag gaaaagccag tctttgcagt agttgagcct gccgttgtac ctttgaaacc
     1441 ttcaggtatg ggactcaaaa tttatatttt attatttgtg ttcctgtccg tatctggtac
     1501 tctcgtgtgg gtgctttttg gcaaaagtct gctggctagc ttgagaaaag aactgaaaaa
     1561 taaggagata gaacaggata aatgatgcta aaacgtcgtt tacaacattc ttatatcaat
     1621 taaattcact tactatatta ttaaacgaat gatacgtaca gctatgataa tggctgcggg
     1681 catgggaacc cgttttggcc aatatacaga attgatacct aaagggttcg tcaaagtggg
     1741 aggtattcca atgatagttc gttctattga tactttgtta tcatgtggca ttgagcgaat
     1801 tgtaatcggt acaggatata aacaagaagt ttatgaagaa ttgaagacag actatcctat
     1861 gcttgaaacc tgttttagtc ctcgttatgc tgaaacaaat agtatgtata ctttatataa
     1921 tacgcgggag attctgggca atgatgattt tttattgtta gagtcagatt tgatttttga
     1981 gaaacaagca ataatgagct tattggagtg tcctgcggca gatgcaatgc taatagctcc
     2041 agtgacaaag tttcaagatc agtattatgt ggaacatgat gataattttc gcctttcttc
     2101 atgttctgtc aataagaata aactaaacgc taaaggcgaa ttggtcggca tccataaact
     2161 atccggttcc ttttacaaaa taatgtgtgc tgattatgcg agtattgttg atgaacaacc
     2221 caatttggga tatgagtatg aattactacg aatatcttgt tctcaatctc ctgtttatgt
     2281 gcataaagta gaagggctga aatggtatga aatcgatgac atatcagatt tggaatatgc
     2341 agagaaatat attgttccgt attgttaatt aaaataatat atcaaattat gagtaagaca
     2401 gtttatattg ggatgactgc ggatattatg catccaggac ttatccgcat tattaatgag
     2461 gctactaaat acggtgatgt tataattggt cttcttacag ataaagctat tgcggagcat
     2521 aaacgccttc cttatctgac ctatgaacaa cgaaaagagg tagttcagaa tattaaaggc
     2581 gtatgtaaag ttgttcctca agaagaatgg agctatgttg agaatctcaa acgcattaaa
     2641 cctgactata taattcatgg tgacgactgg aaaaccgggc ctttacgtga agaacgtgtg
     2701 cgcgtatttg aagtgatgaa tgaacaggga ggaaaggtta tcgaaattcc atatactttg
     2761 ggaattaatt catcttcttt ggataaagat attaaggcta taggtacaac ccccgatgta
     2821 cgtttaaaat cacttcgtcg tttgataaat gccaaacccg tagttcgtat tttggaagct
     2881 catgatggac tatgtggctt gataattgaa aatcaggaaa tattaaaagg ggataagagg
     2941 gaagtatttg acggaatgtg gtctagtagc cttacggatt caaccagtaa aggtaaacct
     3001 gatattgagg cggttgattt aactacccga ttgcaagatt tgaataatat tctggagtgt
     3061 actactaaac ctattatttt tgatggagat acaggtggta aaattgaaca tttcgtattt
     3121 acagtacgca ctttagaacg tcatggaatc tcagctataa taattgaaga taaagttgga
     3181 ttaaaaaaga attcattgtt tggtacggat gttattcaaa ctcaagatac aatcgaaggt
     3241 ttctgtaata agatcaaagc aggaaaggca tctcagatta ctgatgattt tatgattatc
     3301 gctcgtattg agagccttat agcgggaaag ccggtaagtg atgctttaga gagagctttt
     3361 gcatatgtcc aagcgggagc ggacggtatt atgatacata gcaaaaataa gtcgggtgaa
     3421 gatataaaag aattttgttt ggcgtttcga aaacagtatg ctcatgtacc tatcgtggtt
     3481 gtgcctacta catatgatca tatttatgag tctgaattgt gtgattgggg tgtgaatata
     3541 attatttatg ctaatcatat gcttcgtgcc gcttatcctg ctatgatgaa tgtcgcaaag
     3601 acaatattag agaatgaacg tgctttagag gtgcgcgaac tgtgtatgcc cataaaggaa
     3661 atattggaac tgattccggg tactaaataa aaagaggaat atcattatgt taagcgtaga
     3721 aaaagtttat gaaacgtttc tgagtcatga cgttgatttt tttacaggag ttccagactc
     3781 attactaaaa aatatttgtg cctatatcac agaccatact tcacgtgaga aacatatcat
     3841 agctgctaat gaaggtgcgg ctgtaggaat tgcttcaggt tattatatgg catcaggtaa
     3901 ggttcctgtg gtttatatgc aaaattccgg cttgggtaat actgttaatc ctctgctgtc
     3961 tcttgcagat gaacaagtat acagttttcc aatgcttttg atgattggct ggcgtggtga
     4021 accgggaaca aaagatgaac ctcagcataa aaaacagggt gaggtaactt tagatttgtt
     4081 gaaagcaatg cggattcctt atataattct tgattcaaat gagaatgatg catttattca
     4141 gctccatgat atcatacaat cagcaaaaac taagaatatt cctcatgcaa taattattcg
     4201 gaaagatgtt tttggcaaat ataaacttca aaaagagttc ggatgtaatt atcctttatc
     4261 tcgtgaggat gctttgcaaa tagttgtgga ttatctgcct gaaaattcag tggtcgtttc
     4321 tactactggc aagctttctc gtgagttatt tgaatatcga gaaatgaaag agcaaggtca
     4381 tgaacatgat tttctcacgg taggctctat gggacatagt tcatcaatct ctttgggtat
     4441 tgctatagca aagcaagata gacctgttta ttgcttggat ggtgatggag catttattat
     4501 gcatttaggg gcaattagta acattggcga tttatctcct aaaaactatt atcatatttt
     4561 gtttaacaat ggtgctcacg agtctgtagg aggacagcct actttaggat ttagtttaga
     4621 tattccggct attgtccggg ggagcggata taagcatact tatactgttt gtacaaaagt
     4681 tgaaattgaa gaagcaatga agcagcttcc aaagttatgt ggtcctgttt tgttggaaat
     4741 aaaggttaaa atagattctc gggagaattt gggacgtccc acgactactc ctatagagaa
     4801 taaggagcat tttatggatt ttttaaaata aatatattcg atgaaaatag aaagaaaaat
     4861 attattaaat cctgggcctg ccactactac tgacagtgta aaaatggcac aagttgttcc
     4921 ggatatttgt cctcgcgaga aagaattcgc aggtatgatg aaacaacttc gggacgattt
     4981 ggtcagagtt gctcatggga atttggaaaa acataccgct gtattatttt gtggctcagg
     5041 aaccatcaat attgatatat gtctaaattc tcttcttcct gaagacaaaa gggtgcttat
     5101 agtgaataat ggggcatata gtacccgtgc tgtagaagtg tgtcaatatt atggtttgcc
     5161 tcatattaat ttggaatttt ccgtttacga acgtcctgat ttatcggtgg tggaaaatgt
     5221 gttgcaagaa aatcctgata tagctatggt ttatactact catcacgaga cgggtacagg
     5281 aattctgaac cctattcgcg agatgggcgc tatagctcat aaatatcagg ctaaatttgt
     5341 cgtcgatact acttcttctt tgggcatgat tccttttgat atagagaaag ataatgtgga
     5401 tttttgtatg gcatctgctc aaaaaggact tcaagcgatg acaggtcttt cttttattat
     5461 aggcaatgag gaacagatta agttttcaaa aaaatatccc aagcgttctt actattgtaa
     5521 tctttatttg cagtatgaga attttgagag aacaggtgaa atgcatttta ctccaccggt
     5581 acaaactatt tacgccactc gtcaggcatt aaatgaatat tttgaagtgg gcgaagaagc
     5641 taagtttgcc cgtcacaaaa gagtttttga ggctattcat tcaggtataa atgaaattgg
     5701 tcttaaaagt gtaataaagc gtgaatggca gtcaggactg gttgtctcag ttcaataccc
     5761 agaagatccc aactgggatt ttgagaaaat acatgattat tgttatgagc gtggatttac
     5821 gatttatcca ggtaagatat caactgagga tacttttaga atctgtgctt taggagagat
     5881 agaagtagat gatattgaga acttctttaa agtactaaaa gctgcattaa atcattataa
     5941 cgtcacatta ccgatgtcat gattgcagaa atattattga agattcgtca tttttatttt
     6001 tcccttcgtg gtatacactt ccatccggaa agtgttattt ctggagtgcc tattcgtagc
     6061 tttcgcttag taggcaaata tagcaatatc tacttaggta aaaatgctga aatacgttca
     6121 ggctgttatc tgattgctcg tgataaaatc attattggag aaaactcaac actcgcctat
     6181 ggaacgacta tattgacaac tgctgatcct aatggaccgt ataatgcatt agcagttctt
     6241 tatccttata aaaaggcacc ggtagttata ggagataatg tttggattgg ggctaatgtt
     6301 accatccttc ctggagtaac tattggtgat tacgttgtag tagcagctgg agctgttgta
     6361 acaaaagatg taccttcagg agtattggta gctggtgtac cagctattgt gaaaaaacgt
     6421 tttaataaat gaaagaaaaa acttctttaa agaacaaagc catatgtgga atcttttgga
     6481 gtgcagttga acgattttta tcacagggga tacagtttgt agttacagtc attatggcgc
     6541 gttttctatt gccatctgat tatggaatgg taggaatgtt agcaatagtt cttcaattat
     6601 ctcaaacgtt aatggatagt ggttttacta atgcccttat tcgttataag gaacgtactg
     6661 aaattgatta ttcaacagtt ttctttttta atatattagc atcattagtt atttattttc
     6721 taattttttt tctagctcct tatatatcgt ggttttataa aataggtcaa ttagttgaga
     6781 ttactagaat tttatctatt gttattgttt taaattcctt tgcgattatt cctaaaacta
     6841 aattaataat agctgtagat tttaaaactc aatcaaaagt ctcatttatt gcagctttgg
     6901 tttcaggtat tattggcatt tgggctgcat atttagattt tggagtttgg gctttagttg
     6961 gacaaacttt agtaaacgga ttgttgattg tagttttgta tgcatatttt tgtagatgga
     7021 aaccattgtg gatattttca ttgaaatcgt ttcgtttatt atttgctttt gggtcaaaat
     7081 tagtattagc taatattctt aatactttat ataaaaatct gtatgctata gttataggaa
     7141 agaagttttc gtcggttgat ttaggatttt atactcgtgc ggaacaattt gctcagtttc
     7201 cttcatataa tttgagtgca ataatttcta gagtgacata ccccatattg agccttgtgc
     7261 aaaatgataa tgatagatta tctgctttat ataggaaata tgtccgttta tcttctgctt
     7321 ttatctttcc attgatgatt ttgttaattg tcatagctca gccactggta ttattgcttt
     7381 tgacagaaaa atggatagga gtagttgtat tgcttcaaat attgtgttta gattggatgt
     7441 ttgatcattt gagtagtata aatttgaatt tactatatgt aaagggacgt tcagacttgg
     7501 ctttacgttt agaagttata aaaaaagtgt tagcgacggg gatccttctt ctatctattc
     7561 cttgggggat tgtaggtatg tgttgggggc gtgttatgta ttcattgatt gctgtgtatt
     7621 tgaatactta ttatacagaa tcattgatta aattaagtct tattagacag atgagagata
     7681 tactaccaag ctttttttta gcattaataa tgggaggagg tacttggtat atgattttat
     7741 tgttagaggg tgaaattgtt caaattgtag taggaagtgt tattgcttta ttgctatatg
     7801 gaacgttgtt gtattgcttt tctcgatcct tgtttgatga aatatgggcg gttatattaa
     7861 aaataaaaag gtaatggata aactgagttt gattattagt aaaatacgac ggaatcattg
     7921 gtatagaacc tatatgcgtc ctatatattt atttgtttat ggcaatagaa aattgaagaa
     7981 tagaaataga atatttttgc agtattcaca agagctgcta actaactttc atcaagcaat
     8041 gaatgaagtg ggaattcctt attggttaga atttggaact cttttaggtg ctgttagaga
     8101 acacagtttt ataagtcatg attttgatct tgatgtgggc ctttttaagg aagattattc
     8161 agatataata agagaggtct taaaaaaata tggtttcaaa agaataaggt gtataaccgc
     8221 ccttgatttt attgatgctt atgaggaaac ttatctttat aaaggtgtga caattgatct
     8281 tttccttttt tcaagagaga aaaattgtga tggggtctat tgttatgatt ttgttccagt
     8341 atattcagat ataaagagaa ctaaaaaagg tgataatgca atccggagaa ttcattttcc
     8401 tagaattgat ttgattgaat attcatttat tggaattaat acttttgttc ctgaaaatta
     8461 tgaggaacat ctttgtatgc attatggtaa agactatatg attccaaatc ctcattggaa
     8521 agattcagat gcgcaacata ctgatatctt ttatggtaga gagattagaa ttgaattgtt
     8581 tgataaaagt aaataatagt agataataca tgttctatct atttttttta ctaattgtgc
     8641 tatttttgtt atatatacaa agtaggaaaa gacaatattc tactgtagcg ggaatttgtg
     8701 ttcctattat tataattttt gttgtaattt gtcgttatag agtggggtat gactatttaa
     8761 cgtattatac attaattgaa aatgaagaag aggcacagat tttatactta ttttctcctt
     8821 taagcattgt ttgggcagag attgctttat attttgaatc tccacagatg ttatttgttc
     8881 tttttgggct tccaacattt gctcttctaa tatttacttt aaaaaaatat tcaaaagatt
     8941 atgcgttatc agtaactatt ttaatttgtt tcttcttttt tacatcactc agtattattc
     9001 gacaagcttt ggctttggct atttgttttt atggttatcg ttttatagta aaacgttcac
     9061 taattaaata tatattatgt atattgattg cagctttatt ccatccttct gcaggagtag
     9121 cgattattat atattggttg ccatttctaa agtttagatt agttgtatta ttatctataa
     9181 tatcaatagt agccaaacct ttattttttt atatgctaaa tatattaggg gtgtatacct
     9241 cttatcttga tggcaagatg gatattgaag gtgggaaata tactcaatta atatactttt
     9301 tgttgtttat tatttgtttt gttttgggaa gtaaaaacat agataaaaac aagtgtaatt
     9361 tatttaatgt tttattgtta agttttgttt tcgtatcttt tttaggagct catttaggcg
     9421 ggagaatagc gttttatttt aatatatatt attgtttgtt gattcctaaa gtggttaaag
     9481 gattggatgg gcaactaaga gagcaagtga agcttctttc ttattttcta tgtatttctt
     9541 atttcttatt gtacctattc gttccattca taaaaggtgt accctcatat tatatcccat
     9601 ataagtttat atttttcaaa tagtaaaatg ttgatatcta taattgtccc ttgttataat
     9661 tctgaaagat atttgtctga ttgtttattg tctatattga atcaaaccta tgttaattgg
     9721 gaggtgattt gtatagatga tggaagtcaa gataatacat tatctatttt aaatcattac
     9781 gctacattgg atgagcgttt taaaattatt tctcagtcta atgcaggagt gtctgtcgca
     9841 agaaataagg ctctatccca gtgtcaagga gagtatattt gctttgttga tagtgatgac
     9901 ctgatagaac ctaatttttt gataacactt ttacagctta taagtcatca ggctgatttg
     9961 gcaatctgtg gttttactcg ttctatggtt ttctgtatgg atgatgctca aggatatata
    10021 gaaatgagtg gtaaacgttg tatagaaaga attattctag ataaaagttt caatcctcag
    10081 atttgttgta tgttatttcg acataatatt ataaaagaga aacaattaga atttgtgata
    10141 gggtgtactc gtggtgaaga tcgtgaattt atattgaaat atttagttta ttctaataag
    10201 gtttgttata caaacaatct tctttatcac tatcgtgtaa atgatcagtc agccatggca
    10261 atcttttcta ttaaaagttt gacaagtata gaagcttcac aacgcacggt caactactat
    10321 aaaaaagtga attattctgt tagagggctt gaatttgaat tttcacgtac attgtggaaa
    10381 ttcatgattt tagctatttt gtctgggcaa aatgatttat atcaaatcat tcgagaaaag
    10441 tatgatctaa aaagacaaat ggaacatctt tattctcatc caggactatc cgaaaaactt
    10501 acagcgagat tgtttgtttg gaatgaggca ctttttaaat gggtattttc tattattaga
    10561 tatctatata aaaaaagatg gagatgaata aacgaaatag attatctgaa caagaaataa
    10621 aaaaagtaga acttgacgct ttattgtata ttcggaaaat ttgtcagcaa tatcatcttc
    10681 gctattattt agcttggggt actttgttgg gagccgttag gcataaagga tttattcctt
    10741 gggatgatga tattgatata atgatgccac gttcagatta tgagcgatta ttggagttag
    10801 ttccttcctt gagacatagt tattataaaa tcttaagtaa tccaaagaat gaggattatt
    10861 attatactca tgcaaaaatg atagatactc gtactttgtg tgtggaaaat gatttgcaaa
    10921 ctattcaaaa tatggggatt tgggttgata ttttcccctt ag
//
