LOCUS       c00333_gnlPro..        12813 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CPAIFJOA_333.
ACCESSION   c00333_gnlPro..
VERSION     c00333_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 13:00:12
            Original ID  :: gnl|Prokka|CPAIFJOA_333
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12813
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..90)
                     /locus_tag="ctg333_1"
                     /transl_table=11
                     /translation="MAQLNFGGVTETVVIRDEFPLEKAREVLKD"
     protocluster    1..12813
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[867:5034]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      868..5034
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12813
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12813
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(125..868)
                     /locus_tag="ctg333_2"
                     /transl_table=11
                     /translation="MMSENKVGTYRFVAEPFHCDFSGKLTMSVLGNHLLNCAGFHAADR
                     GFGIATLNENHYTWVLSRLAVELENMPCQYEGFSIQTWVENVYRLFTDRNFAILDKEGK
                     TVGYARSVWAMISMETRKPADLLTLHGGSIIDYVCDKKCPISKPGRIKVTEKAPVSEYQ
                     TRYSDIDINGHVNSIKYIEHILDLFPIEFFKEKRIKRFEMAYVAESYYGDILSFYREEV
                     EEKEYDIEVKKNGTDVVVRSKVIFI"
     CDS             complement(868..1422)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg333_3"
                     /sec_met_domain="ALS_ss_C (E-value: 1.7e-19, bitscore:
                     59.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKTLYTLIVHSENIAGLLNQITAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTTQDVIEKVVKQIEKKIDVLQAHYFTDSEIYQHEIALYKVSTPEFQENPM
                     ASKVIRRYSARIVEVNPVFSIVEKNGMSEEITALYEELRGLGCVLQFVRSGRVAITTSC
                     FERVNEYLTQREEKYRQQKTE"
     CDS             complement(1433..1582)
                     /locus_tag="ctg333_4"
                     /transl_table=11
                     /translation="MKREELQAAIHEMLTTDGPFLLEACVIEEGNVLPMTPPGGSVNQM
                     LLEC"
     CDS             complement(1610..3130)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg333_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.7e-39, bitscore:
                     125.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKEKITGAEAMMRSLEYQGVKTLFGYPGGSIMPTFDALYHHRNT
                     LNHILVRHEQGAAHAAQGFARVSGEVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGASFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAVARAFYIAKSGRPGPVVLD
                     FAKNAQVEMVDYEPMKLDFIRSYDPEPNPDKESLQEAAELINNAQRPLVLVGQGVELGN
                     AQDELRAFIEKADMPCGCTLLGLSAIPTSHPLNKGMLGMHGNLGPNVKTNECDVLIAVG
                     MRFDDRVTGKLDTYAKQAKVIHLDIDHSEIDKNVKVDVPVLGNCKYTLAMLTQLIRKNE
                     HSEWIDSFTEYEKTEYEHVISKEIHPVDGALNMGEVVRAVSEASNNEAVLVTDVGQNQM
                     MAARYFKYSKNRSIVTSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELG
                     TIMEQKAPVKIILLNNNYLGNVRQWQAMFFGHRYSFTPMLNPDYMKIA"
     CDS             complement(3232..5034)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg333_6"
                     /sec_met_domain="ILVD_EDD (E-value: 2.4e-217, bitscore:
                     712.4, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNQLRSSFSTQGRRMAGARALWVANGMKKEMMGKPIIAIVNSFT
                     QFVPGHTHLHEIGQQVKVEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGEWNNQHLDLID
                     AMIKSADASVSDEDVAQIENNACPGCGCCSGMFTANSMNCLNEAIGLGLPGNGTILATH
                     ANRTQLFKDAAALIVKNAYKYYEEGDDSVLPRNIATRDAFLNAMTLDIAMGGSTNTVLH
                     LLAIAHEAEVDFKMDDIDMLSRHVPCLCKVAPNTQKYHIQDVNRAGGILNILGELSKGG
                     LLKTDVKRVDGLTLAEAVEKYNICKKEVDTEAKRIYSSAPGNKFNIKLGSQNAVYKELD
                     TDRANGCIRDLQHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFSGPAKVFDSQDA
                     ACEGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSKHLGKECALITDGRFSGG
                     TSGLSIGHISPEAAAGGNIGKIVDGDIIEIDIPNRSINVKLSDEELAARPMTPVTRDRK
                     VPKSLKAYASMVSSADKGGVRIID"
     CDS             complement(5380..5754)
                     /locus_tag="ctg333_7"
                     /transl_table=11
                     /translation="MKRLVLLVVVALGMSATSFAGEKVEGKDWKVDVNVAKLSKYLNLD
                     ARQMEEVANISDYFADKVQSASYAKEAKQGKKLREAVYGNFKLMKRTLTNEQYKKYVQL
                     LNVTLKNKGLDSYMEDVANK"
     CDS             6110..6676
                     /locus_tag="ctg333_8"
                     /transl_table=11
                     /translation="MENKYITVAYKLYVMQDGQKTLVEEATVEHPFQFISGLGTTLERF
                     ETEITALKKGDKFKFVIPTAEAYGEYMPEGVRTVSKDMFTIDGVFDEERIFPGAVIPLQ
                     DNEGHHFYATVSEVTNDTVTVDLNHPHAGKDLTFEGEVVESRTATNEEIQEMVKMMSGE
                     GCGCGCGDCGEGCGDEGGCGCGHCH"
     CDS             7029..8372
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg333_9"
                     /sec_met_domain="Radical_SAM (E-value: 1.2e-10, bitscore:
                     32.0, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRENAKPFAHSKHYLYFWQKYSDQMNENVLAKLKILAESAKYDV
                     SCSSSGTVRRNQSGALGNTVGGWGICHSFAEDGRCISLLKIMLTNYCIYDCAYCINRRS
                     NDIPRATLSVSELVDLTIEFYRRNYIEGLFLSSGVVRNPDYTMERLVRVAKDLRLVHKF
                     NGYIHLKSIPGASRELVNEAGLYADRLSVNIEIPKEENLKLLAPEKDHKSVYQPMRYIQ
                     QGILTNKEDRKKFRHVPRFVPAGQSTQMIVGATTESDKDILYLSSSLYQHPTMRRVYYS
                     GYISVNTYDKRLPALKQPPLVRENRLYQADWLLRFYQFKVEEIVDDSYPDLDLEIDPKL
                     GWALRHPEQFPIDINQADYEMILRVPGIGIKSARQIIASRRFSKLGFYELKKIGVVMKK
                     AQYFITCNELPTRTVNELTPTGVRRLLVPKPKKKVDERQLILNFTDNE"
     CDS             8369..9136
                     /locus_tag="ctg333_10"
                     /transl_table=11
                     /translation="MILFIYDHTFEGLLTCIFDAYFRKTFPDLLLMEGEPLPLFYNEAI
                     HIATDEEKAGRVWRGLQKKISKHALFSLTCCWLSELPKVDEMLFHYIQKAINSPHSIET
                     NFADPDVLELAKIYKRVDGERVHLMQFVRFQKAADGTFFAAVKPQFNALPLAVDHFKDR
                     FADQRWLIYDVKRQYGYYYNLTEMEEVTFEDPRQAHLVTGMLNETLMDNNERLFQELWK
                     TYFKSICIKERWNPQKHRQDMPVRYWKYLTEKQ"
     CDS             complement(9102..9905)
                     /locus_tag="ctg333_11"
                     /transl_table=11
                     /translation="LNFHLVRGFTMRYFIYLAYDGTNYHGWQIQPNGDSVQETLMRAFS
                     TFLRQEIEVVGAGRTDAGVHARLMVAHFDYDQELDCVQITEKLNRLLPSDIAVYDVKRV
                     KDDAHARFDATYRTYKYYVTIRKDPFNRHYAWRLFNSLDFEKMNEAARVLFDYTDFTSF
                     SKLHTDVKTNNCRIMYAEWTRVSGTEWVFTIKADRFLRNMVRAVVGTLVEVGRGKMTLD
                     GFRKVIENKDRCSAGSSVPGHALFLVDVGYPEELFIVSPSDISNT"
     CDS             complement(9910..10584)
                     /locus_tag="ctg333_12"
                     /transl_table=11
                     /translation="MNCMKGACCTLLSLLFSLTVSSGCKEKDMSMKMNEPHNIKGVISY
                     KRSFGDLNDTHLSVAKKIGIRPLASRSEAEGLGGKLVQIKPCERYAMDSLTHSIPFLIP
                     QASALLDTIGANFLDSLSCKGLNPNQIIVTSVLRTADDVKRLRRRNGNASANSAHAFGT
                     TFDVSYRRFCKVEDPDGRPMQDVSPDTLKLVLAEVLRDLRKSDKCYIKYELKQGCFHIT
                     AR"
     CDS             10742..11746
                     /locus_tag="ctg333_13"
                     /transl_table=11
                     /translation="MIEKHIVLEDIDPVIFYGVNNVNMKMIQALYPKLKIVARGNVIKV
                     LGDEEEMCAFEENILALEKHCAQYNSLKEEVILDIVKGRSPQIEKTGDTIVFSVTGKPI
                     VPRSENQLRLVQEYEKNDMLFAIGPAGSGKTYTAIALAVRSLKNKEIKKIILSRPAVEA
                     GEKLGFLPGDMKDKIDPYLQPLYDALQDMIPAAKLKEYMELNVIQIAPLAFMRGRTLND
                     AVVILDEAQNTTTQQIKMFLTRMGMNTKMIVTGDMTQIDLPSSQTSGLIQALKILKGVK
                     GISFIELNKKDIVRHKLVTRIVEAYEKFEEKQKTLHSCHSGRSEKSENIKRIY"
     CDS             11767..12711
                     /locus_tag="ctg333_14"
                     /transl_table=11
                     /translation="MSKALTRTDFNFPGQKSVYHGKVRDVYNINDEKLVMVATDRISAF
                     DVVLPEGIPYKGQMLNQIAAKFLDATTDICPNWKMATPDPMVTVGVMCQGFPVEMIVRG
                     YLCGSAWRAYKNGVREICGVQLPEGMKENQKFPEPIITPTTKAEMGLHDEDISKEEILK
                     QGLATPEEYEILEKYTLALFKRGTEIAAERGLILVDTKYEFGKHNGTIYLMDEIHTPDS
                     SRYFYLEGYEERFAKGEPQKQLSKEFVREWLMENGFQGKEGQQVPEMTPEIVNSISERY
                     MELFEHITGEKFVKADTENIAARIEKNVTEYLK"
ORIGIN
        1 atctttcaat acttcacgtg ctttttccaa aggaaattca tcgcggataa ctacagtttc
       61 tgtaacgccg ccaaaattca attgtgccat tttaaattat aaattaaaaa ttaaaaatta
      121 gattctaaat aaatatcacc ttactacgaa cgacaacatc tgtgccattc ttcttcacct
      181 ctatatcata ttctttctcc tccacttcct cgcggtagaa actcaatata tcaccataat
      241 aactctcagc tacataagcc atctcaaaac gtttaatccg tttctcttta aaaaactcta
      301 taggaaacaa atcgagaata tgttctatat acttaatact gttcacatga ccattaatat
      361 caatatcgct atatctggtc tggtattcag aaaccggagc tttctctgtc accttaatac
      421 gaccgggctt gcttatagga catttcttat cgcatacata atcaatgata ctacctccgt
      481 gaagcgtaag caggtcagca ggtttgcgag tttccatact gatcatcgcc catacagaac
      541 gggcgtatcc gacagtcttt ccttccttgt ccaaaattgc aaaattacgg tctgtaaaaa
      601 gacgataaac attctctacc catgtctgaa tactgaaacc ctcatattga cagggcatat
      661 tctctaactc tacagctaaa cgggaaagta cccatgtata atgattctca ttgagcgtag
      721 caattccgaa accccggtcg gcagcatgaa agccggcaca attcagtaaa tgattaccca
      781 acacactcat ggtcaacttt ccactgaaat cacagtgaaa gggttctgcc acaaatctgt
      841 atgttcctac tttattctca ctcatcatta ttctgttttt tgctggcgat acttttcctc
      901 gcgttgggtc agatattcgt tcacacgctc gaaacagctg gtagtaatgg ccacacgtcc
      961 cgaacggaca aactgcaaca cacatcccaa tccgcgcaac tcctcataaa gagcagtaat
     1021 ttcctcactc atcccattct tttcaacaat agagaaaacc ggattcactt ctacaatgcg
     1081 ggcactataa cggcggataa ctttagatgc cataggattc tcctgaaatt caggagtaga
     1141 aaccttgtac aaagcaatct catgctgata aatctcacta tcagtaaaat aatgtgcctg
     1201 caaaacatct attttctttt caatctgctt caccactttt tctatcacat cctgggtggt
     1261 ccaagcagta atagtatatt tatgcacccc cttgatggaa gatgcagaaa cattaagact
     1321 ttcgatatta atttggcggc gagtaaacac tgccgtaatc tggttcagca aaccggcgat
     1381 attttctgaa tgaacgatta atgtatataa tgtcttgtcc ataattatta aattagcatt
     1441 ccagtaacat ctgattcacc gagcctcccg gaggtgtcat cggcaacaca tttccctctt
     1501 ctatcacaca agcttccagc aggaatggcc cgtcagtagt caacatttca tggatagcag
     1561 cctgcaattc ctcacgcttc ataacacggc gggcaggaat ctcatatgcc taggcaatct
     1621 tcatataatc cggattcaac atcggagtaa atgaataacg atgaccaaaa aacatagctt
     1681 gccattgacg aacattaccc aaatagttat tgttcaataa aataatcttt accggtgctt
     1741 tttgctccat gatagttccc aattcttgaa tattcatctg caaaccgcca tcccccataa
     1801 atacgcatac agtacgatcc gggcgaccga aagtagcgcc tatagcagcg ggaagaccga
     1861 atcccatcgt tcccaatcca cccgaagtta caatgctacg gttcttactg tatttaaaat
     1921 aacgagcagc catcatttgg ttctgtccta catctgtcac caatacagcc tcgttgttcg
     1981 aagcctcact taccgcacgc accacttcac ccatattcaa cgccccgtca acaggatgaa
     2041 tttctttact gataacatgt tcatattccg tcttttcata ttcagtaaag ctatcaatcc
     2101 attcggaatg ttcattcttc cggataagtt gcgtcagcat agctagcgta tatttacaat
     2161 tacctaatac gggtacatcc acttttacat tcttatctat ttcagaatgg tcaatatcca
     2221 aatgaatcac ctttgcctgt ttagcatatg tatctaattt tccagttaca cgatcgtcaa
     2281 agcgcatacc tacagcaatc aacacatcac attcattagt tttgacattg ggccccagat
     2341 ttccatgcat acctaacatt cctttgttta aaggatgcga agttggtata gccgaaagtc
     2401 ccagcaaagt acagccacaa ggcatatcgg ctttttctat aaatgcacgt aactcatctt
     2461 gcgcattacc taactctacc ccctgtccta ccaacactaa tggcctttga gcattgttta
     2521 tcaattcggc agcctcctga agagattcct tatcaggatt aggttctgga tcataactac
     2581 ggataaaatc aagcttcatc ggttcataat ccaccatctc cacttgtgca ttcttggcaa
     2641 agtccaaaac gacaggaccg ggacgtccgc ttttagctat atagaaagca cgggctacag
     2701 cccaagctac atcttccgca cgacgaattt ggtaactcca tttggtaata ggctgagtga
     2761 tgcccaccag atccacttcc tgaaaagcat ccgtacctaa aaaggaagct cctacctgcc
     2821 cggcaatcac cacgataggc gtgctgtcaa tcatagcatc ggcaatgcca gtaatggtat
     2881 ttgtcgcacc gggcccgcta gtcaccaaac agacaccaac ctcaccggat acgcgggcaa
     2941 atccctgtgc tgcatgggca gctccttgtt catgacggac caatatatgg ttcaatgtat
     3001 ttctatgatg atataaagca tcaaaagtag gcatgataga acctccggga tatccgaaaa
     3061 gagttttcac tccttgatac tccaaagaac gcatcatcgc ctctgctcct gttatctttt
     3121 cttttgccat aattgtttag ttgagaattg agaatcaaaa aaatacgatg ccgtacaatc
     3181 gaccaatgac aacaaatcta ttttttttat tctcaatttt taatttctaa tttagtcaat
     3241 gattctcact cctcctttat ctgcagaact taccatacta gcgtatgcct tcaagctttt
     3301 aggaacttta cggtcacggg tcaccggtgt catcggtcgg gcggccaatt cttcgtcact
     3361 cagtttcaca ttgatactgc gattcggaat atcgatttca attatatcac catccactat
     3421 ttttccgata ttaccacccg ctgcagcttc gggagaaata tgcccgatgc ttaatcccga
     3481 agttcctcca ctaaaacgtc cgtcggtaat caaagcacat tcttttccta aatgcttgga
     3541 tttgatataa gaagtaggat aaagcatttc ctgcataccg ggaccacctt tcggaccttc
     3601 atgagtgata acaacaacat ctccgctgac tacttttcct cctaaaatac cttcacaagc
     3661 agcatcctgc gaatcaaaca ccttggcagg ccccgagaat ttccaaatac tttcatccac
     3721 tccggccgtt ttcactacgc aaccatcctg tgcaatgttc cctttcaaaa cggccaaacc
     3781 cccatcttta ctataggcat gttgcaaatc gcggatacaa ccattggcac gatctgtatc
     3841 cagttcttta taaacagcat tctgagaacc taactttata ttgaatttgt ttcccggagc
     3901 acttgaataa atacgttttg cttcagtatc cacttctttc ttacatatat tatatttttc
     3961 gacagcttcc gccaatgtca ggccgtccac tcgtttcaca tcagttttca gcaaaccacc
     4021 cttggataat tctcccaata tattaaggat accaccggca cggttcacat cctggatatg
     4081 atatttctgt gtattcggag ctactttaca caaacaaggc acatggcgtg aaagcatatc
     4141 aatatcatcc atcttgaaat ctacttccgc ctcgtgggcg atagctaaaa gatggagcac
     4201 agtattggta gaaccaccca ttgcaatatc caatgtcatg gcattcagaa aagcgtcacg
     4261 agtagcaatg ttgcgtggta acacgctgtc atctccctcc tcataatatt tataagcatt
     4321 cttcactatc agagcagccg catctttaaa caactgagta cggttggcat gagtcgccaa
     4381 aatagtgcca ttccccggaa gccccagacc aatagcctca ttgaggcaat tcatggaatt
     4441 agccgtaaac atacccgaac agcaaccaca gccaggacat gcattatttt caatttgagc
     4501 cacatcctca tcgctgaccg atgcatcagc agatttaatc atggcgtcta tcaaatcaag
     4561 atgctggtta ttccattctc ccgcttccat aggaccaccc gatacaaaaa cagccggtat
     4621 gttcagtcgc atggcagcca tcagcatacc tggagtgatt ttgtcacaat tactgataca
     4681 caccattgca tccgccttgt gagcattcac catatattcc acgctgtcgg caatgatatc
     4741 acgactgggc agtgaataca gcataccatc gtgtcccata gctattccgt catcaatggc
     4801 aatcgtattg aattctgctg caaaacatcc cagtttttca atctcaactt tcacctgctg
     4861 acctatttca tgcagatggg tatgtcccgg aacaaactgt gtaaacgaat ttactatggc
     4921 tataatgggc ttgcccatca tttctttttt catgccgtta gccacccata aagctctcgc
     4981 tcctgccata cggcgaccct gtgtgctaaa cgaactgcgt aactgattct tcatcttatt
     5041 ctaaatctat aacgtcctat acttattgaa aaagccttcc tcaccatgtg agaaaggctt
     5101 ccaattattt ctttatatgt acaactacac atacacaacc tttctcacgc tcctagtgtg
     5161 accaccacga cgcgaataat atgcaggact gctaggttat tttcgtaaca aacaaataaa
     5221 atgaagattt tttttcttat aaattattat tcgtaactaa atcgagcttt aaacaatcat
     5281 tttatcacaa atatacactg tatcttccaa cggataaata aaaaagagaa tgcattggtt
     5341 tgcattctct tttcagttca tttatttcat tttataaatt tacttattcg ccacatcttc
     5401 catataggaa tccaacccct tgtttttcaa tgtaacattc aacaactgta catacttctt
     5461 gtactgctca tttgtcaatg tacgtttcat cagtttgaag tttccatata cggcttcacg
     5521 caatttttta ccttgtttag cttcttttgc gtagcttgcg ctttgtactt tgtcagcaaa
     5581 ataatcagaa atattagcaa cttcctccat ctgacgtgca tccaaattca aatatttgct
     5641 caactttgcg acgttaacat ctaccttcca atctttacct tctacttttt ctcctgcaaa
     5701 acttgtagct gacattccta atgccactac aaccaacaat actaaacgtt tcataatacc
     5761 taaaatttta atttgttaaa cctaaaaaca atttatttag tacctaagaa ctaaataata
     5821 ccttttaaaa acaatctcgt tatctctttc tctttacact gcaaatataa caacatgctt
     5881 tacgacatgt tgtcatatat ccgttaatta aagcaaaaat ctatcaagga gagcggttaa
     5941 ttgatttata tcaaggatca aacgcaatca aaagcgcatt tatagtatca taataacaaa
     6001 tttatgtaat ataaacgtaa taacaaagga ttaaggggaa ttaattcgta tctttgccaa
     6061 caaaaaactt acgtaaatag tttatattac attattataa taagaaaaca tggaaaataa
     6121 gtacatcacc gtagcataca aactttatgt aatgcaggac ggccagaaaa cattggtaga
     6181 agaagcaact gtagaacatc ctttccaatt catatccgga ttaggaacca cactggaacg
     6241 ctttgaaaca gaaataacag ccttaaagaa gggtgacaaa tttaaatttg tcattcctac
     6301 cgcagaagcc tacggagaat atatgcccga aggtgtgcgc actgtatcta aagatatgtt
     6361 caccattgat ggtgtttttg atgaagaacg catcttcccg ggagctgtca ttcccttaca
     6421 ggacaatgag ggacatcact tctacgctac cgtaagcgaa gtaaccaatg acactgtaac
     6481 tgtagatttg aaccatcctc atgcaggtaa agatctcact tttgaaggtg aagtagtaga
     6541 atcccgcaca gccactaatg aagaaattca ggaaatggta aaaatgatga gtggagaagg
     6601 atgcggctgt ggttgtggtg actgcggaga aggatgcggt gatgaaggtg gatgcggatg
     6661 cggacattgt cattaatttc gttaaacaat agataaagaa gaggacggaa caaaacatcc
     6721 gccctctttt tattattgat aacgaaacaa tactgattgg cagcttcagt gtttcttcaa
     6781 acatttcaaa aaaaagaact tgaagttttc aaaaaagatc tagttctttt ctattaaaca
     6841 tctagttctt ttaaaaaaag aactagacct tttttaaaaa cgtccggttc tttttgacta
     6901 taggaccggt tatcttgatt cataggcgaa acaaatgcat ttagctgggt aataaacaca
     6961 tttttcttct attgcaagac acagataata agactaaaga ataacataat gtaacaaaga
     7021 agttaaaaat gaacagagag aatgccaaac cgtttgccca ttccaaacac tatctgtatt
     7081 tttggcagaa atattctgat caaatgaatg agaatgtcct tgccaaattg aaaatactcg
     7141 cagaatctgc taaatatgat gtttcctgct ctagtagtgg gaccgtgcgc cgtaaccaat
     7201 ccggcgcatt gggaaacacc gtaggcggct gggggatatg ccatagcttc gccgaggacg
     7261 gtcgttgcat atccttgctg aaaataatgc tgaccaatta ttgtatctat gactgtgcct
     7321 attgtatcaa tagaagaagc aatgacattc cccgcgccac gctttcggta agcgaactgg
     7381 tagacctcac catcgaattc taccgacgca actatataga agggcttttc ctcagttccg
     7441 gcgttgtacg caatcctgat tacaccatgg aaaggttggt acgtgttgcc aaagacctgc
     7501 ggttagtaca caaattcaac ggatatattc acctgaaaag tatccccgga gccagtcgcg
     7561 aactagtcaa tgaagccgga ctctacgccg accgtctcag tgtaaacata gaaattccca
     7621 aagaagagaa tctgaaatta ctggctcccg aaaaagatca caaaagtgta taccagccca
     7681 tgcgctatat ccagcaggga atacttacca acaaagaaga ccgaaaaaaa ttccgccatg
     7741 ttccacgctt cgttcctgcc ggacaaagta cgcagatgat tgtcggtgcc acaaccgaat
     7801 cagacaaaga catcctttat ctttcttctt cactctacca acaccccacc atgaggcgcg
     7861 tctactactc tggatatata tccgtaaata catacgacaa acggcttccg gcactgaaac
     7921 agccgccatt ggtacgtgag aaccgtttgt atcaagccga ctggctgtta cgtttctatc
     7981 aatttaaagt agaagaaata gtcgatgact cctatcctga tctagatttg gaaatcgacc
     8041 ccaaattagg ttgggcatta cggcatccag aacaatttcc tatagatata aaccaggcag
     8101 attacgaaat gattctcaga gtaccgggta tcggaatcaa atcggcaaga caaatcatcg
     8161 cgtcacgccg cttctcaaaa ctgggattct atgaactgaa aaaaataggt gtagtgatga
     8221 aaaaagcgca atacttcata acctgcaacg aactccccac ccggactgtt aatgaactaa
     8281 ctccgacagg agtacgcaga ctgttagtac ccaaacccaa aaagaaagtg gacgaacgcc
     8341 aattaatact aaactttact gataacgaat gattctgttt atctatgacc atacatttga
     8401 aggcttgctg acttgcattt tcgatgctta cttccgcaaa acctttcctg acttgctctt
     8461 gatggaaggc gagccgctac ccttgtttta caatgaagcc atacacatag ccactgatga
     8521 agagaaagcc ggacgcgtgt ggcgcggatt acagaaaaaa atctccaagc atgccctttt
     8581 cagcttgacc tgctgctggt tatcagaatt accaaaggtg gacgaaatgc ttttccacta
     8641 tatccagaag gccataaact ctcctcattc tattgagacc aactttgccg atcctgatgt
     8701 gctggagctt gcgaaaatct ataaaagagt agatggagaa cgagtacacc tcatgcagtt
     8761 cgtccgtttc caaaaagcag cggacggaac tttctttgca gccgtaaaac ctcaattcaa
     8821 cgcactgcca ctggctgtgg atcatttcaa agaccgtttt gccgaccagc gttggctcat
     8881 ttatgatgtg aagcgacaat atgggtatta ctataatcta acagagatgg aagaagtaac
     8941 atttgaagat ccccgccaag cacatctggt cacaggaatg ctaaatgaaa cattgatgga
     9001 caacaatgag agattatttc aggaactttg gaaaacatat ttcaagtcca tttgtatcaa
     9061 agaacgttgg aatccccaaa aacaccggca agatatgcct gtcaggtatt ggaaatatct
     9121 gacggagaaa caataaacag ttcttccgga tatcccacat ctactaaaaa caaggcatgt
     9181 cccggcacag aactaccggc actacaacga tctttattct ctatcacctt cctgaaccca
     9241 tctaaagtca ttttaccacg ccccacttcc accagcgtac ctaccacagc ccttaccata
     9301 ttccgtaaaa aacggtcggc tttaatagta aatacccatt ctgttccact cacccgcgtc
     9361 cattcagcat acataatccg gcaattattc gtcttcacat cagtatgcaa tttactgaaa
     9421 ctggtaaaat cagtataatc aaacaataca cgggcagcct cattcatttt ctcaaaatcc
     9481 aatgaattaa aaagcctcca agcataatga cggttaaacg gatctttccg gatagtcaca
     9541 taatacttat aagtacgata agtcgcgtca aaacgggcat gcgcatcatc cttcacccgc
     9601 ttcacatcgt aaaccgctat atcggaagga agcaagcgat tcaatttctc cgttatctga
     9661 acacaatcca actcctggtc ataatcaaaa tgcgcgacca tgagacgtgc atgcacgccg
     9721 gcatcagtac gtcctgctcc cactacctct atttcttgac ggagaaaagt agaaaaagca
     9781 cgcattaatg tttcctgtac actgtcacca ttgggctgaa tctgccaacc gtgataattt
     9841 gtcccatcat aagccaaata tatgaaatac cgcatcgtaa agcctctaac caagtgaaaa
     9901 ttcaataatt cagcgggctg ttatatgaaa acatccctgt ttcaactcat atttgatata
     9961 gcatttgtcc gacttccgaa gatcacggag tacctcggcc aataccaact tcagcgtatc
    10021 cggactaaca tcctgcatag gacgtccatc cggatcttcc actttacaaa accgacggta
    10081 actgacatcg aaagttgtcc caaaagcatg agctgaatta gcagaagcat ttccattgcg
    10141 acgacgaaga cgtttcacat catctgccgt acgaagtaca gaagtaacaa tgatttgatt
    10201 aggattcaat cctttgcaac tcaatgaatc caaaaaattg gctcctattg tatccaataa
    10261 cgcactagct tgcggaatca gaaaaggaat ggagtgagtc agcgaatcca tagcataacg
    10321 ctcacaaggt tttatctgga ccaatttacc acccaatccc tctgcttccg aacgagaagc
    10381 caacgggcga attcctattt tcttcgctac actgagatga gtatcattca aatcaccgaa
    10441 actacgttta tagctaatta caccttttat attatgaggc tcattcatct tcatggacat
    10501 atctttttcc ttgcaaccgg aagaaactgt caaggaaaac aaaagtgaca atagcgtgca
    10561 acatgcacct ttcatacaat tcataatcta actatctttt caaattcctc gcaaagatag
    10621 attaaaatcc tttttctgaa aaagcttatg caaataaatt gcccggaaaa taagaacaat
    10681 gaaaaccttt cattaaattt gcaccctata aacaagtacg taaagtacct aaactagtta
    10741 aatgatagaa aaacatatag ttttagagga tattgatcct gttatatttt atggcgtaaa
    10801 caacgtcaat atgaaaatga tacaagcttt gtatcccaaa ttaaaaattg tggcacgtgg
    10861 aaatgtcatc aaagtattgg gagacgaaga ggaaatgtgt gcttttgaag agaatatatt
    10921 ggctttggaa aagcattgcg cccagtataa ttcactgaaa gaagaagtga ttttagatat
    10981 agtgaaaggt cgttcacccc aaatagagaa aacaggggat actattgtat tcagtgtaac
    11041 aggaaaaccg atcgtccccc gtagtgagaa ccaattgagg ctggtacaag aatatgagaa
    11101 gaacgatatg ctgttcgcta tcggtcccgc aggttcagga aagacctata ccgctattgc
    11161 ccttgctgtc cgttctctga aaaacaaaga aatcaaaaaa attattttga gccgtccagc
    11221 tgtagaggca ggagaaaaac tcggattttt acccggtgat atgaaagata agattgaccc
    11281 ttatctacaa ccactatatg acgcattaca agatatgatt cccgccgcca agctaaaaga
    11341 atatatggaa ctgaatgtga ttcaaattgc cccattggca tttatgcgcg gacgcacctt
    11401 gaatgacgct gtagtgatat tggacgaggc tcaaaatacc accacccagc aaattaaaat
    11461 gttcctcact cgtatgggga tgaacaccaa aatgattgta acaggtgaca tgacacagat
    11521 agacttacca tcttcacaaa cttcgggatt gatacaagca ctaaaaattc tgaaaggcgt
    11581 gaaaggaatc agtttcatcg aactcaacaa gaaggacatt gtacggcaca aactggttac
    11641 ccgcattgtg gaagcatacg agaagtttga agaaaaacag aaaacccttc attcatgcca
    11701 ttctggacga agtgaaaaat ctgaaaacat aaaacgaatt tattgatttt aattataaat
    11761 aaagacatga gtaaagcatt aacaagaaca gactttaact ttccgggaca gaaaagtgtg
    11821 taccacggca aagtgcgtga tgtatacaac atcaatgacg aaaagttagt aatggtagct
    11881 accgaccgta tctccgcatt cgacgtagtt ctgcctgaag gtattcccta caaaggacaa
    11941 atgctgaacc agattgcagc caaatttctg gatgcaacta ctgacatctg ccccaactgg
    12001 aaaatggcga ccccagatcc tatggttacc gtaggagtta tgtgtcaagg ttttcctgtg
    12061 gaaatgattg tccgtggtta cctgtgcggt agcgcatggc gtgcttacaa aaacggcgtt
    12121 cgcgaaatct gtggtgtaca acttcccgaa ggaatgaaag aaaaccagaa atttcccgaa
    12181 ccaatcatta ctccaaccac taaagccgaa atgggcctgc atgacgaaga catctctaag
    12241 gaagaaattc tgaaacaagg tctggctact cccgaagaat acgaaatatt ggaaaaatat
    12301 acattggctc tgttcaaacg cggtactgaa atcgctgcag aacgcggact gatcctggta
    12361 gataccaaat acgaattcgg taaacacaac ggcactattt acctgatgga tgagatccac
    12421 actccggatt caagccgtta cttctatttg gaaggttatg aagaacgctt tgcaaaaggc
    12481 gaacctcaaa aacaactttc taaagaattc gtacgcgaat ggttgatgga aaatggtttc
    12541 caaggcaaag aaggacaaca agttcccgaa atgactccgg aaatcgtaaa ttctatcagc
    12601 gaacgctaca tggaactgtt cgagcacatc accggcgaaa aatttgtgaa agcagacact
    12661 gaaaacatcg ccgcacgtat agaaaagaac gtaaccgaat acttgaaata aataaaaatg
    12721 aaaaattaaa gattaaaaga caagtacagg aatccaaaaa tcctccaccc tctcctttta
    12781 atctttaatt ttcaatttta attaaacatg aac
//
