LOCUS       c00605_gnlPro..        13507 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HMDHHGGE_605.
ACCESSION   c00605_gnlPro..
VERSION     c00605_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 11:04:06
            Original ID  :: gnl|Prokka|HMDHHGGE_605
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13507
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1035
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg605_1"
                     /sec_met_domain="Radical_SAM (E-value: 5.7e-13, bitscore:
                     39.0, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="AQQLSPLTTGLAFDSFAIGGGTPLLLTVPQLEYLLDTAALFGVHP
                     SHTFTSVETSPEYADPTRLDLLKQAGVARVSIGVQSFLDEELTALKRRPRQDMINQALE
                     AIRKRQFPFFNIDLIYGIKGQTVASFLYSLEQALLFQPNELFIYPLYVRPGTAITERES
                     DDVCFQMYCAACDLLKDRGFLQTSMRRFIHHPSTDAEISCGDEVMLSCGSGGRSYLGNL
                     HYATRYTVCQRCIAGEIDDYMGTTDFTVARNGFILSQEERRQRFIIKNLMYYMGLDKTE
                     YKRRFGESPDNVTLFRQLAERQWIENTDNGRVCLTSEGMAYSDYIGQLFITPEIRELME
                     TYSY"
     protocluster    1..13507
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[7133:11345](-)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(7134..11345)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..13507
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13507
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             1047..2612
                     /locus_tag="ctg605_2"
                     /transl_table=11
                     /translation="MENEGSLLSFRRIYYRGKLNSCNYTCSYCPFGKKSHLADTTQDEQ
                     AWNRFIAAIEQWKGEPLQLFIIPYGEALIHRYYRKGMMHLAALPQVAGISCQTNLSFPA
                     KHWLDEIRVTPTMISKIRLWASFHPEMTSVEKFAHQIHILHHAGIQVCVGAVGNPSAKA
                     VLNDLRNTLLPDIYLFINAMQGLRTPLSQEDIQFFSQLDNLFEYDLKNAPAQWEVCAGG
                     RNNCFIDWKGDMYVCPRSRVKIGNFYQGDGAVVPLSCERKVCDCYIAFSNLNNHPLHRI
                     MGEEAFWRIPDKPLITTVFFDVDGTLTDSQGKVPESYANALRYMAQSVSLYLATSLSME
                     QAKKKLGKALFDLFRGGVFADGGLLSYSRQIKCLPVKVYPEVYGESSKVTIHSYEGVVY
                     KYSILVRDKEQRESILTRLKENPCQVFHKAPLITVIHPEASKKEGVLQLCKALGLASEH
                     TLVVGNSLKDWPMMSVVSHSCAVMNAEPLLKERARYTLNPDRLAAFFRFSNGDPIDQTS
                     SDNS"
     CDS             2850..4214
                     /locus_tag="ctg605_3"
                     /transl_table=11
                     /translation="MKELDLTQGSVPKVLLQFAVPFLIANVLQALYGGADLFVVGQYDD
                     SASVAAVAIGSQVMQTITGIILGITTGTTVLIAIATGAKDNRKVAFTIGSSVWLFSITG
                     VVLTLVMVLFHGRIAELMHTPVEAMADTKSYILVCSLGILFIVGYNVVCGILRGLGDSK
                     TPLYFVGLACVINIVLDFILVGYFHWGATGAAIATVTAQGVSFGIALWFLYRHGFHFDF
                     SRKDIRLNRNLSKKILVLGAPIALQDALINVSFLIITVIVNQMGVIASASLGVVEKIIV
                     FAMLPPMAISSAVATMTAQNYGAGLIKRMNKCLASGIGIALVFGVSVCVYSQFLPETLT
                     AFFTKDAAVVAMAADYLRGYSIDCIVVSFVFCINSYFSGQGNSLFPMIHSLIATFLFRI
                     PLSYWFSQIDSSSLFIMGFAPPISTVVSLLICIWYLRYTQRKLYLRGTMMPAMSN"
     CDS             4255..4767
                     /locus_tag="ctg605_4"
                     /transl_table=11
                     /translation="MEAYLKKLCFEYQVDEREVKELLARMEMVYLDKGETIASATLPEQ
                     SLYIIVSGILHTYTTHEGEERTNRFFSAGDAVLCYNSSQYSIKTLTKCAAYYISEEEIE
                     ELCASSISFANLVRQLMEYQFYFKEEEDMNARKLTVRERYLSLLAEIPDILYRVPLKHI
                     NHYLGQM"
     CDS             4926..5804
                     /locus_tag="ctg605_5"
                     /transl_table=11
                     /translation="MKNSIPRYTFYKHKYGSELLVDVVELKYVKKFLAKSAVHTLNYYD
                     ITFITEGKGAFSVNNQTYEAIPRDVLFSKPGEIRNWDTHHITNGYALIFEEEFLSFLFK
                     DSLFVQHLSFFQIESSSSLLHLSDELYTRILETLHDIKMEIDSYQQGDVHVLRALLYEV
                     LMLLDRAYLKMTSIEEGRSREVSNNHVSKFMNLVATHAKEQHSVQYYADKLCITPNYLN
                     EMITSTMGISAKQYIQSKVMEEAKRLLVYTDFPIADIAFELCFSTVSYFIRSFRQHTGE
                     TPLLYRKAHKP"
     CDS             5897..6319
                     /locus_tag="ctg605_6"
                     /transl_table=11
                     /translation="MMRDAEKTVGNMIDKLKTAFIGSIDGEGFPTIKAMLQPRKRKGIK
                     TIYLTTNTSSMRVAQYRENNHACIYFCDTRFFRGVMLRGTMDVLTDSASKEMIWQEGDT
                     MYYPEGVTDPDYCVLKFTAISGRFYSNFKSEDFVVE"
     CDS             complement(6509..7129)
                     /locus_tag="ctg605_7"
                     /transl_table=11
                     /translation="MATTEHSDLEQQIIKTAQQLFIEKGFVETSMSDIAATVGINRPTL
                     HYYFRTKDKMFKAVFGSIVMSLMPKIQDIVKQDIPFMERLSMILDEYIELFTSNPCLPR
                     FICGEIQRDVNHLLATAKELQFGDALSQVKDSILTAMEDGKLKKVPIHIVFLTVYSLLS
                     YPFLAKNLIVSLFLEDEAAFADFLQEWKQNIINQLQNLLCYEE"
     CDS             complement(7134..11345)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg605_8"
                     /sec_met_domain="HGD-D (E-value: 4.1e-23, bitscore: 72.0,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 3.1e-34, bitscore:
                     108.0, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVYKVGLDIGSTTTKMVVLDKDGTTVLFSGYKRHQAKIQECLLG
                     FLYQIKEQLGDIPLSFHITGSVGMGISEKCSLPFVQEVVAATNYVCREHPHTATMIDIG
                     GEDAKVVFFQDGQATDLRMNGNCAGGTGAFIDQMAILLGVSIDELNELALRSNQVYSIA
                     SRCGVFCKTDIQNLIAKNISKENIAASIFHAVAVQTTVTLARGCNIVAPVLLCGGPLTF
                     IPALRKAFANYLNLSQDTDFILPEKGNLIPAWGAALAENNEESIHLSNLIQVIENKLSV
                     TSPFQSDLSPIFDSEEEYRSWKKEKDQYKIQYASLRPGLQEATIGIDSGSTTTKIVVLD
                     NNHRILYSYYHDNNGNPIKTVENGLQKLYEECRRRGTTLRIKGGCSTGYGEDLIKAAFH
                     MDAGIIETIAHYAAAKHISKEVSFILDIGGQDMKAIFVNDGVINRIEINEACSSGCGSF
                     ISTFAQSLDYSVEDFAKAACFSQAPCDLGTRCTVFMNSKVKQVLREGASVADIAAGLSY
                     SVVKNCLYKVLQLKDTEILGDHIVVQGGTMRNDSIVRSLEKLTGKQTFRSNCPELMGAL
                     GCALYAKQIENARVTELNEMLQWAQYTSKQLQCRGCENQCAIMRYTFNNDNHYFSGNRC
                     EKVFSNKGSHADKGINTYDKKLELLFDRSADIPQPLFTIGIPRILNMYEEYPFWHTLFT
                     ACGIQVQLSAPSTFSKYETAAGMVMSDNICFPAKLVHSHIRNLTLQNVNRIFMPFVVFE
                     KKDKQQQNSYNCPIVSGYSEVIKSVQEENIPIDAPTITFKDEALLYKQCYEYLKSLGIR
                     DEVCKNAFSRALQEQYAFEEKIAAYNQEVLNEGREKHKLIILLAGRPYHSDPLIQHKVS
                     DMIAAMGVYVITDDIVRQQEISLEKTHYLSQWAFTNRILKATKWAAMQEGDIQYMQMTS
                     FGCGPDAFLIDEVRNLLKRYGKNLTLLKIDDVNNIGSIKLRVRSLVESLNFSLKHSQAK
                     DPEPFVSTAPFTKKDKKKKILAPFFTPFISPLIPSIMKVAGYEMETLPLSDTASCDWGL
                     KYSNNEVCYPATLIVGDIVKAFKSGRYDPANTCVAITQTGGQCRASNYISLIKKALIEN
                     GYTNTPVVSLAFGSGIENEQSGFKVNWLKVLPIILASVLYSDCIAKFYYAAVVREKERG
                     QAARLRDLYLDTAQPIIQKNKPEDLLSYLYLAARDFNKICEQRSCHKVGIVGEIFLKFN
                     PFAQKDVTSWLINQKIEVIPPLISDFFMQGFVNLKVRQNQHLQRKLTPDFVIDWLYKKV
                     QKQINKVNEIGKNFNYFTPFESIFEKAEKAKQVISPGTQFGEGWLISGEILSFASQGVN
                     HVISLQPFGCIANHIVEKGIEKRIKSLCPQMNILSLDFDSSVSDVNITNRLLLFIDNIN
                     N"
     CDS             12108..12545
                     /locus_tag="ctg605_9"
                     /transl_table=11
                     /translation="MIKTILSVLSLFVMLSCSMTGKKDIKQQPGMCAKLPMAADGIVRL
                     SKIEVYPEYLEEYMKYATEVGEVSLRTEPGVLTMYAVSEKENPGRITILETYASQEAYK
                     SHIASEHFQKYKQGTLHMVKTLVLSDQMPLNPANCINNFIQ"
     CDS             12557..13384
                     /locus_tag="ctg605_10"
                     /transl_table=11
                     /translation="MNKLLLFSVFSILTLNVMAQEKIVQTAGRDQLGTFAPKFAELNDD
                     VLFGEVWSRTDKLGLRDRSLVTITSLISMGITDNSLVYHLQSAKKNGITRTEIAEIITH
                     IGFYAGWPKAWAAFNLAKGVWSEDIVGEDAKTAFQREMIFPIGEPNTAYAQYFIGNSYL
                     APVSREQVNISNVTFEPRCRNNWHIHRATKGGGQMLIGVAGRGWYQEEGKPAVEILPGT
                     VIHIPANVKHWHGAAADSWFAHLAFEVSGENTSNEWLEPVTDDEYNKLEQTKR"
ORIGIN
        1 gcgcaacagt tgtctccact cactaccgga ctggcatttg atagtttcgc cattggagga
       61 ggcacaccgt tgctcctcac tgttcctcaa ctggaatacc tattggatac ggctgcctta
      121 ttcggagtgc atccttcaca tacctttact tccgtagaaa catcgccgga atatgccgat
      181 cctacccgtt tggacttgtt gaagcaagca ggagtagctc gtgtgagtat tggcgtacag
      241 agtttccttg acgaagaatt aacagctttg aaaagacgtc cccggcaaga catgattaat
      301 caggcgctgg aggctatccg gaagaggcaa ttcccatttt ttaatattga tttgatttac
      361 ggaatcaaag gacaaactgt agccagtttt ctttattcat tggaacaggc tcttctgttt
      421 cagcctaacg aactctttat ctatccgcta tatgtacgac cgggaacggc tatcacggag
      481 cgggaatccg acgatgtctg ttttcagatg tattgtgccg cttgtgattt gttgaaagac
      541 agaggttttc tacaaacttc gatgcgacgt tttattcatc atccgtctac tgatgcggaa
      601 atctcatgtg gggatgaagt gatgctgtcg tgtggctccg ggggacgcag ttacctgggt
      661 aatttgcatt atgccacccg gtatactgtt tgccagcgtt gtattgccgg agagatagat
      721 gattatatgg gcactactga ttttacagtg gctcgtaatg gatttattct ttcgcaggaa
      781 gaacggcggc aacgttttat cattaagaat ctgatgtatt atatggggct tgacaagacc
      841 gaatataagc gtcgctttgg agaatcaccg gataatgtga cgttgttccg acagttagct
      901 gaacggcaat ggatagaaaa tacggataac ggtcgtgttt gtctgacttc cgaaggaatg
      961 gcatactccg attatattgg tcagttgttc attactcctg aaataagaga actgatggaa
     1021 acttattctt attgaacgaa atagaaatgg aaaacgaagg ctctttactt tccttcaggc
     1081 gtatatatta tcgcggcaaa ttgaatagtt gcaactatac ctgttcttat tgccctttcg
     1141 gcaagaagtc gcatctggca gatacgaccc aggatgaaca ggcatggaat cgttttatag
     1201 cagctattga acaatggaaa ggggagccgt tgcagttatt tattattcct tacggtgaag
     1261 cattgatcca tcgttattat cggaaaggaa tgatgcattt ggcagcattg ccacaggtgg
     1321 ctggaatttc ctgtcagact aacctttctt ttccggctaa acactggctt gatgagattc
     1381 gtgtgactcc cactatgata agtaagataa ggctctgggc cagttttcat ccagagatga
     1441 cttcggtaga gaaatttgca catcagattc atatactcca tcatgcggga atacaggtat
     1501 gtgtcggagc ggtaggaaat ccctctgcaa aggccgtact caatgattta cggaatactc
     1561 ttttgccgga tatttattta ttcattaatg ctatgcaagg gttaaggaca ccattaagtc
     1621 aggaagatat tcagtttttc agtcaactgg ataatctttt cgagtatgac ttgaagaatg
     1681 ctccggcaca atgggaagtt tgcgcaggag gaaggaataa ttgttttatc gattggaaag
     1741 gggatatgta tgtttgtccc cgaagccggg tgaagattgg taatttttat caaggtgatg
     1801 gagctgttgt gccgctatct tgcgagagga aggtttgtga ttgttatatt gcgttcagta
     1861 acctgaacaa tcacccttta catcgaatca tgggagaaga ggcgttctgg cgaatacctg
     1921 acaagccact tattacgact gttttcttcg atgtggatgg aacactgact gattcacagg
     1981 gaaaagttcc tgaaagttat gctaacgctt tgcgatatat ggcacagtcc gtttccttat
     2041 atcttgccac ttctctgtcg atggagcagg cgaagaaaaa gctgggaaag gctcttttcg
     2101 atttattcag gggaggagtg tttgcagatg gaggtttatt atcttattcg cggcagatta
     2161 agtgtttgcc ggtgaaagta tatccggagg tatatggaga atcgtcaaaa gttactattc
     2221 atagttatga aggagtggtt tacaagtata gtatattggt acgtgataaa gaacagagag
     2281 aatctattct tacccggttg aaagaaaatc cctgccaggt ctttcataaa gctccgctga
     2341 taacagtcat tcatcctgaa gcgagtaaaa aagagggggt gcttcagtta tgtaaggctt
     2401 tgggtttagc ttctgaacac actttagttg taggaaattc gttaaaggac tggccgatga
     2461 tgtccgtggt ttctcattct tgtgccgtaa tgaatgcgga acccttatta aaagaacgcg
     2521 cacgttatac gctgaatccg gatcggttgg cagctttctt tcgtttttct aacggagatc
     2581 ctatagatca aacctcgtct gataatagtt gatatatagc tagttacatc tccataagaa
     2641 aataaaaacc ggttaaaatt tggtaattat gaaaacaaag cccatatttg cagccctgaa
     2701 atagggacag gcataaaaat cctcatcgga gggtgctata ataataatta tagtgctgga
     2761 taagatgaat ggtgcaaatc attcgcttgt ccggcacttt ttttatgttg taacaaaata
     2821 agataaagag gaaaagtatc gaagaaacta tgaaagagtt agatttgaca caaggaagcg
     2881 taccgaaggt attgttgcag tttgcagtac cttttttaat tgctaatgta cttcaggcac
     2941 tttatggcgg ggctgacctt ttcgttgtcg gacaatatga tgattcggca agtgtggcag
     3001 ccgtagctat tggtagtcag gtgatgcaga caataacagg tattattctg ggtattacta
     3061 ccgggacaac agtgctgatt gctattgcta ccggagccaa agacaatcgg aaagtagctt
     3121 ttactatcgg atcttccgta tggttgtttt caataaccgg cgtagtgcta actttggtca
     3181 tggtactttt tcatggtcgg atagcagaac tgatgcatac tcccgtagaa gctatggcag
     3241 atacgaaaag ctatattttg gtatgctctc tgggtattct gtttatagtg ggatataatg
     3301 ttgtatgtgg tattttgcgt ggactgggtg attctaaaac accactttat tttgttgggc
     3361 tggcatgtgt gataaatata gtgctcgatt ttatattggt cggttatttc cattgggggg
     3421 ctacgggagc ggctatcgct actgtaactg cacaaggagt cagctttgga atagcgctct
     3481 ggttcttata ccggcacgga ttccattttg acttttcacg gaaagatatt cgattgaacc
     3541 ggaatctgtc taaaaagatc ttggtgttgg gagcacctat tgctttgcag gatgctttaa
     3601 tcaatgtttc ttttctgatt atcactgtca ttgtcaatca gatgggagtc attgcatctg
     3661 cttccctggg tgttgttgag aaaatcatcg tgtttgctat gctgcctccg atggctatat
     3721 catcggctgt ggcaaccatg actgcacaga attatggagc gggacttatc aagagaatga
     3781 ataaatgtct ggcttcgggg attgggattg ctcttgtttt cggtgtgtcg gtttgcgtgt
     3841 attcgcaatt cctgccggag actcttactg ctttctttac gaaagatgct gctgtggtgg
     3901 caatggcggc agattatttg cgagggtata gcatcgactg catcgtggtt agtttcgtgt
     3961 tctgcattaa ttcttatttc agcggacaag gaaactcgtt attcccgatg attcacagtc
     4021 tgatagccac tttcctgttc cgtataccgt tgtcatactg gttcagccag atagatagct
     4081 cgtcgctgtt tatcatggga tttgctccac ccatttcaac ggtcgtttca ttattgattt
     4141 gtatctggta tttacgatat acccaaagga aattatattt gagaggcaca atgatgcctg
     4201 ctatgtcgaa ttaggtgttt ttaagtgaca tatattaact aaaatctatt ttgtatggaa
     4261 gcttatttga agaaactctg ttttgagtat caggtggatg aaagagaggt gaaagagctg
     4321 ttggctcgaa tggaaatggt gtatctggat aaaggagaaa cgattgcttc tgccacattg
     4381 ccagaacaga gcttgtacat tattgtttcc ggtattttgc atacatatac cactcatgaa
     4441 ggagaagaga gaaccaatcg gtttttctct gcgggtgatg ctgtgttatg ctataattca
     4501 agtcagtatt ctatcaagac actgacgaaa tgtgctgctt attacatcag tgaagaggag
     4561 attgaagagt tgtgtgcatc ttcaatttca tttgcgaatc tggtccgtca actgatggag
     4621 tatcagtttt actttaaaga ggaagaggat atgaatgccc gcaagctgac agtaagggaa
     4681 aggtacctct ctttattggc ggaaattccg gatattctgt acagggtgcc attgaagcac
     4741 attaatcatt acttggggca gatgtgacca gtttgggata tctggccgga agttctaaat
     4801 aggaaatata acctagacat atttttctat gtattcctta tcagatggtt catggcttat
     4861 tcaatcgaat cgaatttgaa aagtctttgg attatttggt aaggaatact atttttgtat
     4921 tctgaatgaa aaactcaata cctcgatata ctttttataa gcataagtat gggagtgaac
     4981 ttttggtcga tgtagtagaa ctgaagtatg tgaagaagtt cctggctaaa agtgctgtcc
     5041 acactctaaa ttattatgat attactttta taacagaagg taagggagct ttttcagtca
     5101 ataaccaaac ctatgaagca attcctcgtg acgttctttt ctctaaaccg ggggaaatcc
     5161 ggaactggga tactcatcat atcaccaatg ggtatgctct gattttcgaa gaagaatttt
     5221 tgtctttcct ctttaaagat tctttgtttg tacagcatct ttcgtttttt cagatagaaa
     5281 gttcttcatc gctactacat ttgtctgatg agctttatac acgcatactt gaaaccttgc
     5341 atgatataaa gatggagatt gattcgtatc aacagggcga tgtacacgtt ttgagagcat
     5401 tgctttatga agtcctgatg ttgctggacc gtgcttacct taaaatgact tcgatagagg
     5461 agggcagaag tagggaagtt tccaataatc atgtaagtaa attcatgaat ttggttgcta
     5521 cacatgcaaa agagcaacat tcggttcaat attatgcgga taagctctgc attactccta
     5581 attatctgaa tgagatgata acctcgacca tgggaatcag cgcaaaacaa tatattcaga
     5641 gcaaggtgat ggaagaggct aagaggctgc ttgtttatac ggactttcct atagctgata
     5701 ttgcatttga actctgtttt tcaacggttt cttattttat ccgtagcttc cggcagcata
     5761 cgggagaaac tccgttattg tatcgtaaag cacacaaacc gtaaaaagtg ctatttctac
     5821 ctttcttttt attgcattgc tttcctggca tttctctact ttcgcatcag ataataaacc
     5881 aataataaaa agtaaaatga tgagagacgc ggaaaaaaca gtaggcaaca tgattgataa
     5941 gctgaaaaca gcttttatcg gttcgataga cggtgaagga tttcctacca tcaaagcaat
     6001 gctgcaaccc agaaaaagaa aggggataaa aactatttat ctgacaacaa atacttcgtc
     6061 catgcgtgtg gcgcaatacc gtgagaacaa ccatgcgtgt atctacttct gtgatacgag
     6121 attctttaga ggtgtcatgc tacgcggtac gatggatgtc ttgacggata gtgccagtaa
     6181 agagatgatc tggcaggagg gagataccat gtattatccg gagggagtga cggatcccga
     6241 ttactgtgta ttgaagttta ctgctatttc aggacgtttc tatagtaatt ttaaatcgga
     6301 agattttgtg gtcgaataag gtgcaagatg gggtgattgg aatggtaata acggagtgtg
     6361 tcaaaacgca gattaacgca aattatcgca gaaataattt tataagtcgt tgattaatat
     6421 atcaatataa ttggaataat ctgcgataat ttgcgttaat ctgcgtttta ttattcatta
     6481 tgacacacct ccttatatag tatctatact attcctcata acacaataag ttctgcaatt
     6541 ggttgatgat gttttgtttc cattcttgca ggaagtcagc aaaagcggct tcatcttcca
     6601 agaataaaga tactatcagg ttcttggcaa gaaatggata gctcaatagg ctgtagacag
     6661 tcagaaatac aatatgtatc ggaacctttt taagtttacc gtcttccatt gctgtcagta
     6721 tactgtcttt cacttgggat aaagcatctc cgaactgaag ttcttttgca gtggcaagca
     6781 agtggtttac atcacgctgt atttctccgc aaatgaatct gggaagacag ggattacttg
     6841 tgaaaagctc aatatactca tccagaatca tgcttagtcg ctccataaat gggatatcct
     6901 gttttactat atcctgtatt ttcggcatta aagacatgac tatcgagccg aacacggctt
     6961 tgaacatctt atctttggtt ctgaaataat aatgtaaagt gggccggttg attcctaccg
     7021 ttgcagcaat atcactcatg ctggtctcca caaatccttt ttctataaaa agttgttggg
     7081 cagtttttat tatttgctgc tctaaatcgc tatgttccgt tgtagccata attttagttg
     7141 tttatgttgt caataaaaag taataatctg tttgttatgt tcacatcgct gacgctactg
     7201 tcaaagtcta aagatagtat attcatttga gggcacagcg attttatacg tttttctatt
     7261 cctttttcta caatgtgatt ggcaatgcat ccgaaaggtt gcaagctaat gacatgattg
     7321 actccttggg aagcaaagga tagtatttca ccggatatca gccaaccctc tccaaactgg
     7381 gtgcccgggg agatgacttg tttagctttt tctgcctttt caaagattga ttcgaacggc
     7441 gtgaagtaat tgaaattttt gccgatttca ttcactttat taatctgctt ctggactttc
     7501 ttgtataacc agtcgataac aaagtcggga gtgagttttc gctgcaagtg ttggttctgt
     7561 ctcactttca ggttgacaaa tccctgcatg aagaaatcac ttatcagtgg cggaatcact
     7621 tcgatcttct ggttgatgag ccatgaggtg acgtcctttt gagcaaaagg gttgaacttc
     7681 aggaatattt ctccaacaat acctactttg tgacaggatc tctgttcaca gattttgttg
     7741 aagtctctgg cagcgagata taagtaactc aacaagtcct ccggtttatt tttctggatg
     7801 atgggctgtg ctgtatccag ataaagatcg cgcagacggg cggcctgtcc ccgttctttc
     7861 tcacgaacga cggctgcata atagaattta gcgatacaat cactgtataa cacagacgca
     7921 agtatgattg gcaaaacctt gagccagttt actttaaaac cggattgctc attttcaata
     7981 ccactgccga aagcaagtga taccaccggt gtattggtgt atccattctc aatcaatgcc
     8041 ttttttatca gtgaaatata gttgctggca cgacattgtc caccggtttg tgtgatggca
     8101 acgcacgtat tggcaggatc ataacgtccg cttttaaagg cttttactat gtcgccgaca
     8161 atcaatgttg ccggataaca tacctcatta ttggagtatt tcaatcccca gtcgcaagat
     8221 gcggtgtcgc tcaacggtaa cgtttccatt tcatatccgg ccactttcat gatggatgga
     8281 atgagtggtg aaatgaaagg cgtaaagaat ggagcgagga ttttcttctt tttgtctttc
     8341 ttggtgaaag gagcagttga aacaaatggc tcgggatctt tcgcttgaga atgtttcaaa
     8401 ctgaaattca agctttccac caacgagcgg actcgtaatt tgatggagcc gatattatta
     8461 acatcgtcta tcttgagcaa agtaagattc ttgccgtatc gtttcagcaa gttacgtact
     8521 tcatctataa ggaaagcatc cggaccgcag ccaaaagaag tcatctgcat atattgtatg
     8581 tcaccctctt gcattgccgc ccacttggtt gctttcagaa tacggttggt aaatgcccat
     8641 tgagagaggt aatgagtctt ttccaatgaa atctcctgct ggcggacaat atcatcagtt
     8701 atcacataaa ctcccatcgc agcaatcatg tccgaaacct tgtgctgtat cagtggatcg
     8761 ctatggtaag ggcgtccggc gagtaagata atcagtttgt gtttttcccg tccctcgttc
     8821 agaacttcct gattataggc agcaattttt tcttcgaaag catattgttc ctgtaatgcg
     8881 cgtgagaagg catttttgca tacctcatcc ctgataccca aagatttcag atattcatag
     8941 cattgtttat acagcaatgc ttcatctttg aaggtgatag tcggagcatc tatcggtata
     9001 ttctcttcct gtacactttt gatgacttcc gaataaccgg aaacgatggg gcaattatag
     9061 ctgttttgct gttgcttatc ctttttctcg aaaacaacga acggcataaa tatccggttg
     9121 acgttttgca gtgtcaggtt acggatatga ctgtgcacaa gtttggcagg gaagcagatg
     9181 ttatcagaca tcaccatgcc ggcagcagtc tcgtatttgc tgaatgtaga gggggccgac
     9241 aactgtacct gaatgccgca agcagtaaat aaggtatgcc agaaagggta ttcctcatac
     9301 atattcagaa tacgtggaat gcctatggta aataggggtt gtggaatgtc tgcgctccgg
     9361 tcgaataata attccagctt tttatcatac gtattgatgc ctttgtccgc atggcttcct
     9421 ttattggaaa ataccttttc acatcggttg ccggagaagt aatggttgtc attgttgaac
     9481 gtatatcgca taatggcgca ctggttctcg cacccccggc attgaagttg cttggaagta
     9541 tattgcgccc attggagcat ctcgttcagc tccgtcaccc gggcattttc gatttgtttg
     9601 gcatataggg cacaaccaag agcacccatc aattcaggac agttactgcg gaaggtttgt
     9661 ttcccggtca gcttttccag acttcgtacg atggaatcat tacgcatggt tcctccctgc
     9721 acgacaatat ggtcgccaag tatctccgtg tcttttaatt gcagaacctt atacaggcag
     9781 tttttaacaa cggaataaga taatccggca gctatatccg ctacggacgc tccttcccga
     9841 agtacctgtt ttactttgga gttcatgaag actgtgcaac gtgtacccag atcacatggt
     9901 gcttgcgaaa aacaagctgc tttggcaaag tcctccacac tgtaatccag cgattgcgca
     9961 aatgtgctga taaaagaacc gcaaccggag gaacaggctt cattgatttc gattctgttg
    10021 attactccgt cgttcacaaa gatggctttc atatcctgcc ctccaatatc caggataaaa
    10081 gaaacttctt tgctgatatg tttggcagca gcataatgag cgatggtttc aatgattccc
    10141 gcatccatgt ggaaagccgc ttttatcaga tcttctccgt aaccggtaga acatcctcct
    10201 tttatgcgca gggtagttcc tcgtctccgg cattcttcat atagtttctg caagccgttc
    10261 tctactgttt ttatagggtt tccgttgttg tcgtgataat aggagtaaag gatacgatga
    10321 ttgttgtcga gtactacgat tttggtggta gtagagccgg agtctatgcc gatagttgct
    10381 tcctgtaatc cgggacgcag actggcatat tgaattttat actggtcttt ttcttttttc
    10441 catgaccgat attcttcctc actgtcgaat ataggagaaa gatcactctg gaaaggtgag
    10501 gtaacactta gtttgttttc tattacctgt atcaggttgg agagatgaat actttcttca
    10561 ttgttctctg ccaatgctgc tccccaggca gggatcagat ttcctttttc cggtaatatg
    10621 aaatctgtat cttgtgacag attcagatag ttggcaaatg cttttcgaag ggccggaata
    10681 aaagtcaatg ggccaccgca gagtaatacc ggagctacga tattgcaacc gcgtgcaagt
    10741 gtgacagtgg tctgtacggc tactgcatgg aaaatggaag ctgctatatt ttctttagat
    10801 atatttttgg ctatcagatt ctgtatgtcc gttttgcaga atactccgca gcgtgaagcg
    10861 atagagtata cctgattgga acgaagtgct agttcattca attcgtcgat ggagactcca
    10921 agcagaatag ccatctggtc aatgaaagcc ccggttccgc cggcgcaatt tccattcatg
    10981 cgcaggtctg tagcctgtcc gtcctgaaag aaaacaactt tcgcatcttc tcctccaata
    11041 tcgatcatag tggctgtgtg cggatgctcc cggcacacat agtttgttgc agctacaacc
    11101 tcttgcacaa acggcagaga gcatttctct gaaattccca ttccaacaga gcccgtaatg
    11161 tggaaagata aaggaatatc acccaactgt tcctttattt gataaagaaa tccgagtaaa
    11221 cattcttgta tttttgcctg atgccttttg tatccggaaa acaagactgt agttccatct
    11281 ttatccaata ctaccatctt agtggtagta gagcctatat ctaaacccac tttatataca
    11341 ttcatatacc aaatatctta aattagacct cgtgtttgac atctgtgtca gacgcaaatg
    11401 tatgtaaaaa tatggtagat acggcaaatc gtaattgaag tttttgattt aattaacgaa
    11461 ttgggaaaaa agaaagatgg aatgtgaggg aggaaaacga tcgtgtaaaa aaagacgtaa
    11521 atgaataatt gtgtatttat attacttgtt gggttgtagt agatctttta tggtgaatct
    11581 tagaaatctt gtttactcta tttttgacaa aaggtaacgt ggcttttaat aaacccggat
    11641 tctgtttata ataaactttt tgatagtttt agtaaaacgg tattcgagtt tattataaac
    11701 tattgtagaa cagttctagg atcagacgag agattttaag ctgaattata aacaaaatgg
    11761 ggcaataatc attcgactat tgccccatat cgtataggag tggtattgta aaataccagg
    11821 ttatttatga tttatgtatg attatttctt tctattttca tgttgtttat actttttctt
    11881 ttctcaaaga tacaacataa aaagtcattt gtcaagagtc tgatgagaaa agtagcttat
    11941 cggtctcaaa acagatgaat aactttactt ctaatatctg atttttattc ggctttatta
    12001 cagaatcggg gatttgggta caaaaatccg taattgatat acaattccat tcgttttatc
    12061 gcagtaaatt tgcaatcaga agtttaacaa tgaaaagata gaagatgatg ataaaaacaa
    12121 ttctaagtgt tttgtcttta ttcgttatgt tatcatgcag tatgacaggg aaaaaggata
    12181 taaaacagca gcctggtatg tgcgccaaat tacctatggc ggctgacggt attgtgcggc
    12241 tatcgaaaat cgaggtttat ccggagtatc ttgaagaata tatgaaatat gcgaccgaag
    12301 tgggtgaagt ctccttgcgt actgaaccgg gagtgctgac tatgtatgcc gtcagcgaaa
    12361 aagagaatcc tggcaggata actattcttg aaacttacgc gagtcaggag gcttataaat
    12421 ctcatattgc atcggagcat tttcaaaagt acaagcaagg aacgctgcac atggttaaga
    12481 ctctcgtact ctctgaccaa atgccgctta accccgcaaa ttgcattaat aacttcattc
    12541 aataaacgaa atgattatga ataaactcct tttattttca gtatttagta ttttaacact
    12601 caatgttatg gcacaagaaa agatagtaca gacggcagga cgcgaccagt taggaacgtt
    12661 tgcccccaag tttgcggaac ttaatgacga tgttctcttt ggagaagttt ggagccgcac
    12721 tgacaaactc ggtctgcgtg accgcagttt agtaaccatt acctccctta tcagtatggg
    12781 aatcacggac aattcgctcg tttatcatct tcagtcggcg aagaagaacg gcatcacccg
    12841 cacggagatc gcagagatta tcactcatat aggtttctat gcaggttggc cgaaagcgtg
    12901 ggcagcgttc aatttggcaa aaggagtatg gtctgaagat attgttggtg aggatgccaa
    12961 aacagctttc cagcgtgaga tgattttccc tattggcgaa cccaatacag cctatgcaca
    13021 gtattttatt ggtaacagtt atcttgctcc ggtttcgcgc gagcaggtga atatctctaa
    13081 cgttactttt gaaccacgtt gccgcaataa ctggcatatt caccgtgcaa cgaaaggtgg
    13141 cggacagatg cttatcggtg tagccggtcg aggctggtat caggaagaag gtaaaccggc
    13201 ggtagagatt ctgcctggta cggttatcca tattcctgcc aatgtgaaac actggcacgg
    13261 agctgctgcc gacagttggt ttgctcatct ggctttcgaa gtttccggtg aaaacacttc
    13321 caatgagtgg cttgagccgg tcacagatga cgagtataac aaactcgaac agactaaacg
    13381 atgatttttg ctaatcctgc tttatctttt gaaaggaaat aatatgacta ccgaggaatt
    13441 ttaaggaata tgtaaagacg cgcaaagcgc ttaatacaga agaaatacat cgtttgatgg
    13501 acgatat
//
