LOCUS       c00660_gnlPro..        12046 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HMDHHGGE_660.
ACCESSION   c00660_gnlPro..
VERSION     c00660_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 11:04:06
            Original ID  :: gnl|Prokka|HMDHHGGE_660
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12046
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..588)
                     /locus_tag="ctg660_1"
                     /transl_table=11
                     /translation="MFNSFGNIFRLTSFGESHGKGIGGVIDGFPSGITIDEEFVQQELN
                     RRRPGQSILTTPRKEADKVEFLSGIFEGKSTGCPIGFIVWNENQHPNDYNNLKNVYRPS
                     HADYTYTVKYGIRDHRGGGRSSARETISRVVAGALAKLALRQLGVNITAYTSQVGPIKL
                     EGTYSDYNFDLIETNDVRCPDPEKAKEMADLIY"
     protocluster    1..12046
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5913:12007]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      5914..12007
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12046
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12046
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             750..1316
                     /locus_tag="ctg660_2"
                     /transl_table=11
                     /translation="MKKNLLYLWALVCSLTLFAACSSDDDDSDNKNNENPPEEEAVITA
                     PDVIGTYWGNLDISMIPDGSDQEIVIGDGIEKFITLSQVSNTEVKIELKDFELFINQQI
                     LKFGDIVIDKCEVKKGEGMSTFTGQQDLTFEGDAASLGTCPVTVTGTVEGGNADMTINV
                     KVPALQQTVKVTYSGVKQVAEPSGT"
     CDS             complement(1313..2098)
                     /locus_tag="ctg660_3"
                     /transl_table=11
                     /translation="MKIYPYIFSLLTCIGIALPGYAQVDRNETLIRSALHGLEYEIKAG
                     FSIGGTAPLPLPVEIRSIDGYNPTLAISIGGEVTKWIAVQNKLGIIVGLRLENKAMTTE
                     ATVKNYNMEILGQGGERISGVWTGGVKTKVHTAGLTIPLMATYKLTNRWNIKAGPYFSY
                     LLSREFSGHVYEGYLREDDPTGPKVEFTDGKIATYDFSDDLRHFQWGLQVGAGWRAFKH
                     LNVYADLTWGLNDIFKNNFNTVTFAMYPIYLNIGFGYAF"
     CDS             complement(2221..3306)
                     /locus_tag="ctg660_4"
                     /transl_table=11
                     /translation="MKAKHVIFYLLLAIVSSSCIREEALNAEADILSCILPGVAMTTSP
                     IINNNSISIFVGPGTDISELKPEFTLTPGATISPLSGTERNFSTPQEYTVTAADGVWKK
                     TYIVSVIDTELATNYNFEDTLGGKKYYIFVEREGDKVVMEWASGNAGYAMTGVAKTADD
                     YPTFQITDGKVGKCLSLVTRSTGFFGQIAGMPIAAGNLFIGSFDVSNAMSNPLKATKFG
                     LPFRHVPTYLAGYYKYKAGDQFTEGGKPVNGKRDICDIYAIMYETSESVPTLDGTNAFT
                     SPNLISTARIDNAKETNEWTYFKLPFITLPGKFIDKEKLRNGKYNIAIVFTSSLEGDHF
                     NGAIGSTLLIDEAELIYHSEN"
     CDS             3440..4726
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg660_5"
                     /sec_met_domain="SDH_alpha (E-value: 4.9e-62, bitscore:
                     199.4, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTESERRQIIELIKKEVIPAIGCTEPIAVALCVAKAAETLGAKPE
                     KVEVLLSANILKNAMGVGIPGTGMVGLPIAVALGALIGKSDYQLEVLRDCTPEAVEQGK
                     LFIAEKRICISLKEEITEKLYIEVICKTGDKTAKAIIAGGHTTFIYIARDEQTLLDKQH
                     TVSEEEEEASPELNLRKVYDFALTAPLDEIRFILDTARLNKAAAEQAFKGNYGHSLGKM
                     LRGTYEHKVMGDSVFSHILSYTSAACDARMAGAMIPVMSNSGSGNQGISATLPVVVFAE
                     ENGKNEEELIRALMLSHLTVIYIKQSLGRLSALCGCVVAATGSSCGITWLMGGNYNQVA
                     FAVQNMIANLTGMICDGAKPSCALKVTTGVSTAVLSAMMAMEDRCVTSVEGIIDEDVDQ
                     SICNLTRIGSQAMNETDKMVLDIMTHKGC"
     CDS             complement(4854..5432)
                     /locus_tag="ctg660_6"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYTMEDGEKELFEEAKAEHPFQFISGLGTTL
                     EDFENQITALSKGDKFDFTIPADKAYGQYDEQHVIDLPKNIFEIDGKFDSERIKEGNIV
                     PLMTGDGQRVNASVVEIKPDIVVVDLNHPLAGADLIFEGEILESRPATNEEIQELVKMM
                     SGGDGCGCGCDSCGDGCGDDCGCEGGHCH"
     CDS             5914..7713
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg660_7"
                     /sec_met_domain="ILVD_EDD (E-value: 9e-217, bitscore:
                     710.2, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQLRSSFSTQGRRMAGARALWAANGMKKNQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQLVKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVSDQEVANIEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRTQLFKDAAELIVKNAKLYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAEVDFKMDDIDMLSRKAPCLCKVAPNTQKYHIQDVNRAGGIIAIMDELAKGG
                     LIDTSVRRVDGMSLAEAINEYSITSPNVSEKAIKKYSSAAGNKFNLVLGSQGMYYKELD
                     KDRANGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEA
                     ACEGILGGRVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHISPEAAAGGNIGKIVDGDIIEIDIPARKINVRLTEEELAARPMTPVTRDRY
                     VPKSLKAYASMVSSADKGAVRII"
     CDS             7838..9532
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg660_8"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.8e-47, bitscore:
                     148.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDLITGAEALMRSLEHQGVTTIFGYPGGSIMPVFDALYDHQNIL
                     NHILVRHEQGAAHAAQGYARVSGDVGVCLVTSGPGATNTVTGIADAMIDSTPIVVIAGQ
                     VGTGFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAVARAFYIARSGRPGPVVLDF
                     AKNAQVEKTKYEPTKVDFIRSYVPVPDTDEESVQAAAELINNAERPLVLVGQGVELGNA
                     QSELREFIEKADMPAGCTLLGLSALPTEHPLNKGMLGMHGNLGPNINTNKCDVLIAVGM
                     RFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDVAVLGDCKETLASVTKLLKKNTH
                     TEWIDSFKEYEKVEEEKVIRPELHPATNSLSMGEVVRAVSDATHHEAVLVTDVGQNQMI
                     SARYFKYTKERSIITSGGLGTMGFGLPAAIGATFGAPERTVCVFMGDGGLQMNIQELGT
                     IMEQKAPVKIICLNNNYLGNVRQWQAMFFNRRYSFTPMLNPDYMKVASAYDIPSKRAFT
                     REELKEAIAEMLATDGSFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             9590..10147
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg660_9"
                     /sec_met_domain="ALS_ss_C (E-value: 2.2e-19, bitscore:
                     59.1, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITAWTDKDIIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQENP
                     EASKLIRRYNARIVEVNPVFSIVEKNGMSEDITSLYGELKALNCVLQFVRSGRVAITTS
                     CFERVNEFLDGREAMYNQSKNQ"
     CDS             10153..10896
                     /locus_tag="ctg660_10"
                     /transl_table=11
                     /translation="MSEENRIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHANDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYENFSVQTWVENVYRLFTDRNFAIIDKDGK
                     KIGYARSVWAMINLNTRKPADLLTLHGGSIVDYVCDEPCPIEKPSRIKVTSDQPIATLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIELYKTKRIRRFEMAYVAESYFGDELSFFCDEV
                     NANEFHVEVKKNGNEVVCRSKVIFE"
     CDS             10964..12007
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg660_11"
                     /sec_met_domain="IlvN (E-value: 3.5e-46, bitscore: 146.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 7.2e-42, bitscore: 132.7,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGTTETVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     ALNLHDNGFNVIVGQREGKTYDKAVADGWVPGETLFGIEEACEKGTIVMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWNDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGKAYERTIALGIGIGSGYLFETTFQREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHSPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYNSVKTGNEAQISIDSNSQPDYREKLNEELRQLRESEMWQTAVTVR
                     KLRPENN"
ORIGIN
        1 atatataagg tctgccattt cttttgcttt ttcagggtcc gggcaacgta catcgttggt
       61 ttctatcagg tcgaaattat agtccgagta agtaccctca agcttgatag gacctacctg
      121 tgaggtatag gcagtgatat tgactcccag ttggcggagt gccagcttag ccaatgcacc
      181 ggctacaacg cgcgaaatcg tttcgcgtgc agaggaacgt ccgccgccgc gatggtcacg
      241 gattccatac ttcaccgtgt atgtgtaatc agcgtgtgaa ggacgatata catttttcag
      301 attgttgtag tcattggggt gttggttttc attccaaacg ataaaaccga taggacaccc
      361 ggttgatttc ccctcaaaaa tacctgaaag aaactctact ttatcagctt ctttgcgtgg
      421 ggtggtaagg attgattgtc ccggacgacg gcgatttagt tcttgttgta caaattcttc
      481 gtcgatggta attcctgatg ggaatccgtc aatcactcct ccaattcctt ttccatgaga
      541 ctcaccgaaa cttgtgagtc gaaagatatt gccaaatgaa ttaaacatag ttgtggcttt
      601 ttaaaaatta ctatatgcaa atataacaaa gttttcggta agaaagttgc gaactcgaaa
      661 taacttcgaa aaaggaagca tattgaacct tttttcttct ttttagttta taaaggacga
      721 atttattgta ataactaaac caaagacgta tgaaaaagaa tctattgtat ttatgggcat
      781 tggtatgttc tcttactctc tttgctgctt gtagcagtga tgacgacgat agtgataaca
      841 agaataatga gaatcctccc gaagaggaag ctgtgataac ggctccggat gtaatcggaa
      901 cgtattgggg aaatctggat atatccatga taccggatgg ctccgatcag gaaattgtca
      961 tcggcgacgg aatagagaag tttatcacgc tttcgcaggt cagcaatacg gaagtgaaga
     1021 ttgaactgaa ggattttgaa ttgttcatca accagcagat attgaaattt ggagatattg
     1081 tcattgataa atgtgaagtg aaaaaggggg aaggtatgtc tacattcacc ggacagcaag
     1141 atcttacatt tgaaggagat gctgcctctt tgggtacttg tcctgtaaca gttacgggaa
     1201 ctgtagaagg tggaaatgca gacatgacta ttaatgtgaa agtgcctgca ttgcaacaga
     1261 cggtgaaagt aacctactcc ggagtgaagc aggtggcaga gcctagcggg acttaaaaag
     1321 catacccgaa acctatattc aagtagatgg ggtacatggc aaaagtgact gtattaaaat
     1381 tgtttttaaa tatatcattc aatccccagg taagatcggc atacacattg aggtgcttga
     1441 aggctcgcca tccggctcct acctgtaatc cccactggaa atgtcttaaa tcgtccgaga
     1501 aatcgtatgt tgcaattttg ccgtcggtaa actctacttt cggaccggta ggatcatctt
     1561 cccgcaaata tccttcatat acgtgtcctg aaaattctct tgaaagcaga taggagaaat
     1621 aaggcccggc tttgatgttc caccggttgg ttagtttgta ggtagccatc agaggtattg
     1681 tcagtccggc ggtatgtact ttggttttta ctccgcctgt ccatactccg ctgattcttt
     1741 cacctccctg cccgagaatc tccatattat aattcttcac ggtggcttcg gtagtcattg
     1801 ctttgttttc aagccgcaat ccgactataa ttccaagctt attctgaacg gcaatccatt
     1861 tggtcacttc gcctcctata ctgatagcta atgtcgggtt atatccgtca atggaacgga
     1921 tttctaccgg aagaggaagc ggggctgtgc cgccaatact gaaacctgct tttatctcat
     1981 attccagtcc gtgaagggcg gaacggatca gtgtttcatt tcgatcaacc tgtgcatagc
     2041 cggggagggc tattcctata caggttagta aactgaatat atacggatag attttcatcg
     2101 ttcttgttgt tataaagtta tttaattccg ttcgtttgat aacgtgcgca ttttgtatga
     2161 gtacattact tgagcacact atcagcgtat ttctgtggaa aatccttcat cggaattccg
     2221 ctaattttcc gagtgataga tcaactcggc ctcgtcgatt agtaatgtac tcccgattgc
     2281 tccgttaaaa tgatcccctt ccaagcttga ggtgaacacg atggctatgt tatatttccc
     2341 attccttagt ttctccttat ctatgaattt tccggggaga gtgatgaaag gaagtttaaa
     2401 gtaagtccat tcattcgttt ctttggcatt atcaatccgt gctgttgaaa tcaggttcgg
     2461 actggtgaat gcatttgttc catcaagagt gggaacggat tcgctcgttt cgtacatgat
     2521 ggcatatatg tcacagatgt cccgtttccc gttcacgggc tttccgccct ctgtaaactg
     2581 atctcccgct ttgtatttat aataacctgc cagataagtg ggcacatgcc ggaaaggaag
     2641 gccgaatttg gtcgctttca gcggattgct cattgcgttg ctcacatcga aagaaccgat
     2701 aaacagattt cctgccgcaa taggcattcc tgctatctga ccgaagaatc cggtactgcg
     2761 tgtcactaaa gagaggcatt tgccgacttt tccgtccgtt atttggaaag tgggataatc
     2821 atcggctgtt ttagctactc cggtcatggc gtagcccgca tttccgctgg cccattccat
     2881 gacgacttta tctccttcgc gttccacaaa tatatagtac ttctttccgc ctagtgtatc
     2941 ttcgaaatta tagttcgtgg caagctccgt atcgataact gatacgatat atgttttctt
     3001 ccaaacaccg tcggcggctg tgacagtata ttcctgtggg gtactgaaat ttcgttctgt
     3061 accgctaagc ggactgatcg tagctcccgg agtcagggta aattcaggct taagttctga
     3121 aatatcagtt cccggaccga caaagattga gatggaatta ttattaatga taggactggt
     3181 tgtcatggct actcccggta gtatgcaact taatatgtct gcttctgcat tgagagcttc
     3241 ttcgcggata caggaagagg aaacaatagc cagtagcaaa tagaaaatta cgtgttttgc
     3301 tttcattttt ctatcaattc tttctgttaa agtttagtgt aggggagatt ttataacaat
     3361 atgagatttt atttgttcat tatagaatgt tggaaaagaa agaatttcct atttttgtgg
     3421 aaccaaaatt tataagtcca tgactgaatc agaaagaagg caaattatag aattgattaa
     3481 gaaagaggtc attccggcta ttggatgtac ggaacctatc gcagtggcgc tttgtgtagc
     3541 taaagctgcc gaaacactgg gagcgaaacc ggaaaaggta gaagtcctgt taagtgctaa
     3601 tatattaaag aatgccatgg gagtcggaat accgggaact ggtatggtcg gacttcccat
     3661 agctgttgct ttgggtgcgt tgattggcaa atcagactat cagttggagg tgttgaggga
     3721 ctgtacgccg gaagcagtgg aacaaggaaa actgttcatc gcagaaaaac ggatttgtat
     3781 ttctctaaag gaagagatta cggaaaaact ttatatcgaa gtaatctgta aaacgggaga
     3841 taaaacagct aaagccatca ttgccggtgg gcatactacc tttatatata tagccaggga
     3901 tgaacaaacg ttgctcgaca agcaacatac ggtcagtgag gaagaggaag aggcttcgcc
     3961 cgaattaaac ttgcgtaaag tctatgactt tgcactgact gctccgctgg atgagatccg
     4021 cttcatcctt gatacagccc gcttgaacaa agctgctgcc gagcaagcct ttaaaggtaa
     4081 ctacggacat tctttaggta aaatgcttcg gggaacttat gagcataaag tgatggggga
     4141 tagcgtgttt tctcatatcc tctcttatac gtcagctgct tgtgacgccc gaatggccgg
     4201 tgctatgatt cctgtcatga gtaattccgg cagtggtaac caaggaatat ccgctacact
     4261 ccccgttgtt gtttttgccg aagaaaacgg aaagaacgaa gaggaactga tccgtgcttt
     4321 aatgttaagc catctcactg ttatatatat caaacaaagt ttgggacgtt tgtctgcttt
     4381 gtgtggctgt gtggtagctg ccacaggttc cagttgtgga atcacctggt tgatgggagg
     4441 aaactacaat caggttgcct tcgccgttca aaacatgatt gctaatctga caggaatgat
     4501 ttgtgacggt gcaaaaccga gttgtgcttt gaaagtaacc accggagttt cgacagccgt
     4561 attatctgcc atgatggcaa tggaagaccg ttgtgtgact tccgtggagg gaattatcga
     4621 cgaagatgta gatcaaagta tctgtaactt gacaagaatc ggctcgcaag ccatgaacga
     4681 aacggataaa atggtgcttg acatcatgac acacaaagga tgctgatttt aagtattagg
     4741 tatcaagtat taagtattag ccggaatgac ggcataaaaa aagtattaag tattaaaact
     4801 ccagctatat cagcacgaaa ttaatactta atactttata cttaatgctt caattaatga
     4861 cagtgtccgc cttcgcaacc gcagtcgtcg ccacagccat caccgcagct gtcgcatccg
     4921 caaccgcagc catcaccacc actcatcatt ttcacaagtt cctgaatttc ttcgttcgta
     4981 gcaggacggc tttccagtat ttcaccttca aagatcaggt cggcaccagc caacggatgg
     5041 ttgaggtcaa ctactacaat atccggtttg atttctacta cgctggcatt tacgcgttga
     5101 ccgtcaccag tcatcaaagg tacgatgtta ccttctttaa tacgttcgct gtcaaatttg
     5161 ccatctattt caaatatatt tttggggagg tcaatgacgt gttgttcgtc atattgtcca
     5221 taagccttat ctgccggaat ggtaaagtca aatttatcac ctttagaaag agcagttatt
     5281 tgattttcga agtcttcgag tgttgttcct aatcctgaaa tgaattgaaa gggatgttct
     5341 gcttttgctt cttcgaacaa ctctttttca ccatcttcca ttgtatatag tttgtatgca
     5401 acggtaatgt acttgttttc tactgtttcc atctgatatt ttttgtttct gattaataat
     5461 tcccggtaat ccgggtcaac aaagatacga attatttgct tgtcctccgg tatagggagg
     5521 gtaaatttca gattattaag tgcttttgtc agaaaaggaa ggtggagtat gtacttagat
     5581 aatagttgta aattcaacct ttaagtgata aaatagagaa ataacacctc tcttttctta
     5641 caattattcg cttttaagtg atttttttct tcgatttgtt tggatataat aaaaaagccc
     5701 ttacctttgc agcacgaaaa taaagaaaag aagatatgaa tatgttacat acatctatta
     5761 acctagcagt cctgcatatt attcgcgtcg tggtggtccc atcaagagcg tgagaaaggt
     5821 ttttgtgttg tatgtgttcg taccataaaa gatagaattt agagcctttc tcacttgtgt
     5881 gaggaaggct ctttaattaa aagatagatt gaaatgaaaa agcaattacg cagttcgttt
     5941 agtacacaag gccgtcggat ggcgggagcc cgtgcgttat gggcagccaa cggcatgaag
     6001 aagaatcaga tgggtaaacc cattatcgct atcgtcaatt cgttcacaca gtttgttccg
     6061 ggacatgtgc atctgcatga aatcggtcag ctggtgaagg cagagattga gaagttggga
     6121 tgcttcgctg cggaattcaa tacaatagct atcgacgacg gtatagcaat gggacatgac
     6181 ggtatgcttt actcgcttcc ttcacgtgac atcattgcag acagtgtaga gtatatggtt
     6241 aatgcgcaca aggcagatgc aatggtatgt atcagcaatt gcgataagat tactcctgga
     6301 atgttgatgg cggctatgcg tctgaatatt cctgccgtat ttgtatcggg tggtccgatg
     6361 gaagcgggag aatggaatgg ccagcacctg gatttgatcg atgcgatgat taaatcggcc
     6421 gacgaaagtg tcagcgatca ggaagtagcg aatatcgagc aaaatgcttg tcctacttgc
     6481 ggatgctgct ccggtatgtt taccgccaac tcgatgaact gcctgaatga agcaatcgga
     6541 ctggctcttc ccggcaacgg aaccattgta gcgacacacg aaaaccgtac gcaacttttc
     6601 aaagacgctg cggaactgat cgtgaaaaat gcaaaattat attatgaaga aggagacgaa
     6661 agtgtacttc cccgtagcat cgctacccgt caggctttcc tgaacgccat gacgctggat
     6721 atagcaatgg ggggatctac caatacggtt cttcacttgt tggccgttgc tcacgaagca
     6781 gaggtagact tcaagatgga tgatatcgac atgctttccc gcaaggctcc ttgtctctgc
     6841 aaggtggctc ccaatacaca gaaatatcat attcaagatg taaaccgtgc tggtggtatc
     6901 attgccatta tggacgaact ggcaaaggga ggtttgatag atacatccgt tcgtcgggta
     6961 gatggaatgt cactggcaga agccattaac gaatattcaa tcaccagccc gaatgtgagc
     7021 gaaaaagcaa ttaagaaata ttcgagcgca gccggaaata aattcaatct tgtacttggt
     7081 tcacaaggta tgtactataa ggaactggat aaagaccgtg caaacggatg tatccgtgac
     7141 ttggaacatg cttacagtaa agacggcgga ctggccgtat tgaaaggcaa tattgctcaa
     7201 gacggttgtg tagtaaaaac agcaggtgta gacgaaagta tctggaagtt taccggacct
     7261 gccaaagtat ttgattcgca agaagcagcc tgtgaaggca tcctcggagg tcgagtcgtc
     7321 agtggagacg tcgtcgtcat cacgcacgaa ggtccgaagg gtggtcccgg tatgcaggaa
     7381 atgctttatc ctacctctta tataaaatcc cgtcatctcg gaaaagaatg tgctttgatt
     7441 accgacggac gtttcagcgg tggaacttcc ggattgagta tcggacatat ttctcctgaa
     7501 gcggcagctg gaggcaatat cggaaaaatt gtagacggag acattatcga aatcgatatt
     7561 ccggcccgga agattaacgt gcgactgacg gaggaagaac tggcggcccg tccgatgact
     7621 cctgttactc gtgaccgtta tgtaccgaag agcctgaagg cgtatgccag catggtaagc
     7681 tctgccgata agggagcagt gagaattata taatatagtt ggtgatagtt gataggtaat
     7741 agttagctgc gcagcactta gcgcaatgat tgtaaaccat tcattttcaa ctgtcatttc
     7801 tcaactatca tttatcattt atcaactatc aactaatatg aaagatttaa taacaggtgc
     7861 agaggctttg atgcgctcct tggaacatca gggagtgact accatctttg gttaccccgg
     7921 tggttctatt atgccggtat tcgatgcctt gtacgatcat caaaatatat tgaatcatat
     7981 cttggttcgt cacgaacagg gagctgccca tgccgcacag ggttatgccc gtgtatcggg
     8041 tgatgtaggt gtttgcctgg tgacgagcgg tcccggagca accaatacgg taacaggcat
     8101 tgcggatgcg atgatcgata gtacgcctat cgtagtgatt gccggacagg tcggaacagg
     8161 ctttcttggg acggatgctt ttcaggaagt tgacttggta ggtatcaccc agccaatcac
     8221 taaatggagt tatcagattc gccgtgcgga agatgtagcc tgggcggtag cacgtgcgtt
     8281 ttacattgct cgtagtggtc gtccggggcc ggtggtactg gactttgcca aaaatgcgca
     8341 agtagagaaa acgaaatacg aaccgacgaa agtcgatttt atccgtagct atgttcctgt
     8401 tcccgatacg gacgaggagt ctgtacaggc tgctgccgaa ctgattaata acgctgaacg
     8461 tccgcttgta ttggttggac aaggtgttga actgggaaat gcacagagcg aattgcgcga
     8521 gtttatcgaa aaagcggata tgcctgcggg ttgtacgctg ctcgggcttt cggctttgcc
     8581 aacagaacat ccgttgaata aaggtatgtt gggtatgcac ggcaatctgg gaccgaatat
     8641 caataccaat aaatgtgatg tgctgattgc tgttggtatg cgttttgatg accgtgtgac
     8701 cggtaatttg gctacttacg ccaaacaggc aaaagtgatt cattttgata tcgatcctgc
     8761 ggaagttaat aagaatgtaa aggtagatgt agctgtattg ggagattgca aggaaacact
     8821 ggcttctgtg acgaaacttc tgaaaaagaa cactcatacc gaatggattg atagcttcaa
     8881 agaatatgag aaagtagagg aggaaaaagt aatccgtccc gaacttcatc ctgccacaaa
     8941 ctcgttgagt atgggggaag tggtacgtgc ggtaagtgat gctactcacc atgaagctgt
     9001 tttggtaaca gatgtaggtc aaaatcagat gatatctgca cgctacttta aatatacgaa
     9061 agaacgcagt atcattactt ccggaggact tggaacaatg ggcttcgggc ttcccgcagc
     9121 tatcggggca actttcggag caccggaacg caccgtatgc gtatttatgg gagatggcgg
     9181 actgcaaatg aatattcagg aactgggtac gattatggag cagaaggctc cggtgaagat
     9241 tatctgcctg aacaataatt acctaggaaa cgtacgtcag tggcaagcta tgtttttcaa
     9301 ccgtcgctat tcgtttaccc cgatgttgaa tccggattat atgaaagtgg cctcggctta
     9361 tgatattcct tccaaacgtg ctttcactcg tgaagaactg aaggaagcta ttgctgaaat
     9421 gctggcaacg gacggttcgt tcctgctcga agcttgcgtg gtggaagaag gcaatgtttt
     9481 gccgatgact cctccaggtg gttcggtaaa ccagatgttg ctggagtgct aggagaagtt
     9541 gagagttgag aatggagagt tgagggttcg catttaaaaa attagagtta tgagtgataa
     9601 aacgttatat acaatcattg ttcattcgga gaatatagcc gggttgctga atcaggtaac
     9661 tgctgtattt acccgtcggc aaataaatat tgagagtctg aatgtatctg cttcttctat
     9721 taaaggtgta cataagtata caataacagc ctggactgat aaggacatca ttgagaaggt
     9781 agtgaaacag atcgaaaaga agatcgacgt gattcaggca cattatttca cagaggatga
     9841 gatttatttc cacgagattg cattatataa ggtgtctact cctgcttttc aggagaatcc
     9901 ggaagcatcc aagctgattc gtagatacaa tgcacgtata gtagaagtca atccggtatt
     9961 ttctattgtc gagaaaaatg gaatgagcga agatataact tcgctctatg gtgaactgaa
    10021 ggctttgaat tgtgttttgc agtttgttcg ttcgggacgt gtagcgatta ctaccagctg
    10081 ctttgaacgg gtgaatgagt ttctcgatgg acgggaagct atgtataacc aaagtaaaaa
    10141 ccaataagaa taatgagtga agaaaataga atagggactt atcagtttgt ggcagaaccg
    10201 ttccatgttg acttcaacgg acgtctgact atgggggtac tgggaaatca tctgctgaat
    10261 tgtgcaggtt ttcacgccaa tgaccgtggt tttggtattg caacgctgaa tgaggacaat
    10321 tacacatggg tgctttcacg tctggctatt gagttggatg aaatgcctta tcagtatgag
    10381 aatttctcgg ttcagacgtg ggtggaaaat gtctaccgct tgtttacgga ccgtaatttt
    10441 gctattattg ataaggatgg gaagaagatt ggctacgcac gttccgtatg ggcaatgatt
    10501 aatcttaata cccgcaagcc tgccgacttg ttgactttgc atgggggaag tatcgtagac
    10561 tatgtctgtg atgagccttg cccgattgaa aagccttcac gcatcaaagt gacaagcgat
    10621 cagccgatag ctaccctgac ggcaaaatac agtgatatag atatcaacgg tcatgtaaac
    10681 agcatccgtt acatcgagca tatccttgat ttgttcccga ttgaattgta taagaccaag
    10741 cgtatccgtc gttttgaaat ggcgtatgtg gcggaaagct attttggtga tgaactctct
    10801 ttcttctgcg atgaagtgaa cgcaaacgag tttcacgtag aagtgaagaa gaatggtaac
    10861 gaagttgttt gccgctcgaa agtgatattt gaataaatgt gagaatataa aatcaattaa
    10921 taacagatgg cgtaagtcat caaaaactaa aaacaaaaag aaaatggcac agttgaattt
    10981 tggaggtact actgaaactg tagtaatccg tgacgaattt ccattggaaa aagctcgtga
    11041 agtattgaaa aatgaaacaa tcgctgtaat cggttatggc gtacagggtc ctggacaggc
    11101 actgaacttg catgataacg gtttcaatgt aatcgttggt caacgtgaag gaaaaacata
    11161 tgataaggca gtagcagacg gatgggttcc gggtgaaact ttgttcggta tcgaagaagc
    11221 ttgtgagaaa ggtactattg taatgtgtct gttgtctgac gcagcagtaa tgtcagtatg
    11281 gcctactatc aagccttacc tgactgccgg aaaagctctt tatttctcac acggttttgc
    11341 tatcacttgg aacgaccgta caggtgtagt gcctcctgct gatatcgacg ttatcatggt
    11401 tgctcctaaa ggttcgggta cgtctttgcg tactatgttc ctcgaaggac gtggcttgaa
    11461 ctcttcttat gctatctatc aggatgctac aggcaaggct tacgaaagaa ctatcgcact
    11521 gggtatcggt atcggttccg gttatctgtt cgaaacaact ttccagcgtg aagctacttc
    11581 tgacttgaca ggtgaacgtg gttcattgat gggtgctatc caaggtttgt tgctggcaca
    11641 gtacgaagta ttgcgtgaaa acggtcatag tccttctgaa gcattcaatg aaacagtgga
    11701 agaactgaca cagtcgttga tgccgttgtt cgcaaagaac ggtatggact ggatgtacgc
    11761 taactgctct actactgctc aacgtggtgc tctcgattgg atgggcccat tccacgatgc
    11821 tatcaaaccg gtagttgaaa agttgtataa cagtgtgaag actggtaacg aagcgcagat
    11881 ttctatcgac agtaattcac aacctgatta tcgtgaaaaa ttgaacgaag aactccgtca
    11941 attacgcgaa agcgaaatgt ggcagactgc tgtaactgtt cgtaaacttc gtccggagaa
    12001 taattaatta gactagatta tacaagtttt aaaagaagga gagggc
//
