LOCUS       gnlProkkaJDDFBJCG_447  12518 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JDDFBJCG_447.
ACCESSION   gnlProkkaJDDFBJCG_447
VERSION     gnlProkkaJDDFBJCG_447
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 11:04:16
            Original ID  :: gnl|Prokka|JDDFBJCG_447
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12518
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12518
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[4313:7518]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4314..7518
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12518
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12518
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(93..242)
                     /locus_tag="ctg447_1"
                     /transl_table=11
                     /translation="MYSSEDLASFYFQYQTKALPHVKFLQSFCMKHKVPIIFFISGIRI
                     RVIK"
     CDS             complement(390..1508)
                     /locus_tag="ctg447_2"
                     /transl_table=11
                     /translation="MIIGLGSVGCYLLDYLVSLGDSQLRLVVVGRNAEKMQMDINIIRT
                     ASTIRHQCRSEIKVVDNCDLNDVNSIAAVLEAEKPDFIVNSSRVYSGLKYGSISWSNLR
                     AYGIWTPLSIRYAKNIMEAYDKANCEAISINTSYSDAVIPWLKSAGKAYFDFGSGNLNH
                     LVPRIKFYIAEKYGIKNFNDIDVTIAVSHFHDVVISKEGHAEGQDILLDIKFQGKDMDF
                     NKEELLKSCSIAMPVDQKRNMMNASSNFDIIFSVLTALREEKQVKIHTPGVNGEIGGYP
                     IIIDGVTATAKFDESVWTIDQMRKANRESIYCDGVENITDATLVYTDELVAKVKKSFNV
                     DLPKSVKFVDIENVADLIINQIIKPQVLIFVQ"
     CDS             complement(1565..2572)
                     /locus_tag="ctg447_3"
                     /transl_table=11
                     /translation="MAVLERDYRIDGIKWLLIVLVTFGHVIEPALSNPIANKLYSIIYI
                     FHMPLFVFISGYYANVKDKEKLISKGIMLLETFLVVMIPQCFYYGSIIPLLNPENSGWY
                     LISLITWYIIFLLIINKLVGKIVVQYNGCGGQLLIFSCLLAVFAYMLPLKQFGNLLSFQ
                     RSCMFLPFFMMGFLRRVKGLPIIPDVSKCIKLVLAIASLVCFAFCLIYSGRILHVLEFN
                     NANVWHMSNLYNQNIGMLLVLKVLVYIGSIITTFAVLMFVNLPKSICAYGSKTLAYYVI
                     QGMFAHILSTYLQVNFYQALFLCVCILVLTTVLLRFVDSKFITNPFSTLLKWKY"
     CDS             complement(2581..3321)
                     /locus_tag="ctg447_4"
                     /transl_table=11
                     /translation="MKYLIITVAGTATRFNRDTKEETLKCLYYTDEPQYALLAQLLKNC
                     GEYDKYILVGGYLYEKLGRFVKNELSGYGKKIELVYNEHFKDYGSGYSLYKGIEAIKEA
                     GDVTFVEGDLFFMATDFRQVYNSPKSVITINREPIYSNKAVALYINVDGKPRYLYDTNH
                     QTLTVSEPFKAIFNSGQMWKFSSSERLLKTVDSLTKEQLQGTNLEIIQAYFSDMNSEEY
                     DVVTFTDWFNCNTVADYDIVRKLM"
     CDS             complement(3318..4313)
                     /NRPS_PKS="Domain: NAD_binding_4 (83-198). E-value:
                     6.4e-10. Score: 30.4. Matches aSDomain:
                     nrpspksdomains_ctg447_5_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     143.1; E-value: 2.2e-43)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg447_5"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.1e-09,
                     bitscore: 27.6, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 3.8e-09, bitscore:
                     25.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLYVISGVTGMTGSELSRQFVSQGHTVIGFDNFFASSIDTVKD
                     IIDNPSFIFYNYDINKVAQMDEVCDKAKELKIECDGRLVFINCAAVVHTKHFYEVESTF
                     QTNVLAMKDFLERAISMRADTYINCSTSEVYSMQSWNENGGVKESDYLAMSTAEHSQRT
                     SYACGKLMTEFFMKDAVGKGRIKGCSIRFANVYSRHERFAEHIIPHIIDNLLESHTVTL
                     LENSKVNKRTFLHNIDSCRAVMELIASEDALDGTVYNVATEEEIAIIDLVKTIAIKMGI
                     NDVDIRFEGYRKSDPERRLLNTDKIRTRTSWKPIITLDEGLTMCVNSIKK"
     aSDomain        complement(3720..4064)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg447_5_NAD_binding_4.1"
                     /evalue="6.40E-10"
                     /label="ctg447_5_NAD_binding_4.1"
                     /locus_tag="ctg447_5"
                     /protein_end="198"
                     /protein_start="83"
                     /score="30.4"
                     /tool="antismash"
                     /translation="VFINCAAVVHTKHFYEVESTFQTNVLAMKDFLERAISMRADTYIN
                     CSTSEVYSMQSWNENGGVKESDYLAMSTAEHSQRTSYACGKLMTEFFMKDAVGKGRIKG
                     CSIRFANVYSR"
     CDS             complement(4314..5042)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Metallophos_2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg447_6"
                     /sec_met_domain="Metallophos_2 (E-value: 5.1e-28, bitscore:
                     88.0, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVILFADIHANLSAFEAVLADIEKHYQPDAMISLGDFIDYGMRS
                     NEIIERIQTVNIPLLANLKGNHEKALIDGELSCFSSERARVMSKYTRNHLTQTSIDYIS
                     NVMQEPMQELEIGGKKVLLLHGTIDDPYWGKLTPAKVEDEKYQDFDYVLSGHIHQPFKI
                     DVFFKVDNPIMRNQKRTTFINPGSVGQPRNQNPYAQYVYINFKTGETHFNAVPYDIEAE
                     QSLFPKEIDTFYSERLKFGI"
     CDS             complement(5046..6173)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 74.7;
                     E-value: 1.1e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg447_7"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.1e-20, bitscore:
                     63.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.2e-24, bitscore:
                     74.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRPEFFVNILKEQGIDFYAGVPDSLLKNICAYITDHLPAEQNII
                     AANEGGAMGIAVGYHLATGKVPVVYMQNSGEGNIINPFASLTDKDVYNIPVLLVIGWRG
                     RPGVHDEPQHVKQGKVTIGLLNTMGINYAILPKDEEGAAKQIKIAVDFMKATNECYALV
                     IEKDTFDTYKLQSVEVNELAMSREETIQKVASNIEDNACIVSTTGMISRELFEARTAWS
                     QGHERDFLTVGAMGHASQIALGIALQKPERRVYCFDGDGASIMHMGNMAITASMKCKNY
                     VHIVFNNGAHDSVGGQPTVGLKIDFCAIAQAVGYKAAYSVETMEALEAKLAEFKNAEGP
                     VFLQICVKKGNRKDLGRPTTTPIQNKEAFMEFLNK"
     CDS             complement(6208..7518)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 190.9;
                     E-value: 4.6e-58)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg447_8"
                     /sec_met_domain="CTP_transf_like (E-value: 1.3e-12,
                     bitscore: 37.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.5e-114, bitscore:
                     371.6, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 9.5e-62, bitscore:
                     198.3, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTVYLGMIGDIMHPGYINIINKATEYGDVIIGLFTDKAIANHR
                     RLPYLTWEQRKNVVESIRNVSRVVPQDDWSYVSNLLKYKPDYIIHGDDWQVGPDKYIRD
                     EVFKVMEKLGGEVIEIPYTQNISASGIKQEIDALGVTPQMRLSSLRRLIAAKPIVRILE
                     SHNGLTGLIAEHTKVEVNGQEREFDGMWASSLTDSTSKGKPDIEAVDLTTRLHDLNDTL
                     EVTTKPVIFDGDTGGKIEHFGFTVRTLERLGISCVIIEDKVGLKQNSLFGTDAVQTQDT
                     IEGFQAKIRAGKEAQITRDFMIVSRCESLIAGKTVDDALERCHAYVEAGTDGIMIHSKE
                     KSGEDIKEFCLRFREKNAHTPIIVVPTTYNQFTEEELAEWGINVVIYANHMLRSAYPAM
                     VKCAETILYTSRSLEASEQYCMPIKQILNLIPGTKKK"
     CDS             complement(8201..9367)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg447_9"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2e-33, bitscore:
                     105.2, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVIYIQDQEIDHYNGQFYHSKSEHFFSRFLAGLNENDTLTVYTG
                     IINRNCAQEVAKYKDVTNPRITYKQVPEFRNPKNLLAINRLMKRVLKDADFCYLRSGIA
                     ASFASTICLKKHIPYMAVVNEDIFRNTIAHSRLLVRLSAYPLSYYTHRMVREANYACYV
                     TQDYLQSNYPCKGKSLGCSDIEFLDINELSLTKRLNKIQKQEGTIVLGTVGSVDTELKG
                     QDTIIKALAKLKAEGFTNYIFQMVGTGKPNRLRNLAAELGIANQIEFLGEFKHDDVQKW
                     FETIDIYVHPSRSEGLPRTILEAMTKAVPCICSSVGGIPELIDGDSLFTYDGTEIDTLV
                     NIIKGFSKDKMEFEAKINFERSKNYEPKLLEQKRTVFFAQAINEFRKK"
     CDS             complement(9388..10662)
                     /locus_tag="ctg447_10"
                     /transl_table=11
                     /translation="MLLFFTLITIIIDLFYLFVSLKAVLKNRYSILHLCSILFFIIQVL
                     PLVVDMFNDVNSLGTHTKYLYNALTDENTAYLYNLFAIFVMVGLTSTAQKFAHKRVNIM
                     FQRTKAINSFYRLCIVLLMFAPVAAVILAPTPEIYTNFSYFYTHSYNPLAVEYLYHRLV
                     MPYIIYLSFLSILVYYYLIKGSTSKNIIMLLSSVICIWIDGKRGLLAFLIVGILLVDFI
                     KNQTQSNWKLVKKGALLSCVFIAYFAVYSMFTTKNTDDSFYETYDAYFSRESEVKLSIY
                     SRLNGADMLPYDGATLLYDITCYIPRFLWEDKPYGFFNYLTAYAYNGHAETFMEGSNFQ
                     VNIWSEYIANFGLLGCILSLLFIIGIVRVSERSNVAMLNISGSVFVLIYLFFGFELIVM
                     VLFYAWLYFFVFKRKSSLHRTRTTY"
     CDS             complement(10684..11898)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg447_11"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.5e-13,
                     bitscore: 39.8, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVLIWDLNYVLKNSGGPAGYLYNIREYLLKHPTKDAEIHFLKD
                     DLGIPNVDRSVNTNHKDLMKKIHKLDILSLMGYFRTFRCLMYWNKKLSAKSISGINLND
                     FDAIHFHNSGDLYRASELLRSYEGKIILTTHSPQPKACEDVENIVYKWSVLRRLIKKQI
                     LKKELQGWEKADYIMFPVQGALEPYYVEKEIKDYKDCNTDKFIYCESSILDKPISKPLD
                     REELGIDSSKYLICYLGRHNEIKGYDQLKLFAEHILSKDSRFEFVIAGNEEPLTRLDHP
                     NWKELGWINYGNRLVSSSDIFILPNKETYFDLVTLEVMREGIPILMSRTGGNKFFERYG
                     EEYGIFLYNYGDIKDQEAQFNKMIYELENGILKVKAKKLRNLFIEHFTMEHYISRYIET
                     VKNIC"
ORIGIN
        1 acgtaataaa gtaatttact tctttttatc tttgttgtga tatccatatt tattacattt
       61 ttcatttgac aatcggagat atagaactgt aattatttta ttacgcgtat ccttatacca
      121 cttatgaaaa atattatagg aactttatgc ttcatacaaa aggactggag gaacttgaca
      181 tgaggtaaag ccttggtctg gtactgaaaa taaaaacttg ctaaatcttc gctgctatac
      241 atatcttgct aattttaatt tacaacgaag gctaacattt cattttgaac tttttaaagt
      301 gcttacatag ctgtgtatat cataaaacta taagttaaag attatacaga aaattaacaa
      361 caatctatta tctgccatta gtttacaaat tattgcacaa aaataagcac ttgaggttta
      421 attatctgat tgataattaa atctgctaca ttttcaatat ccacaaactt taccgactta
      481 ggcaaatcaa cattaaacga cttctttacc ttagctacaa gttcatcagt atagacgaga
      541 gtagcgtcag ttatattctc tactccatca caataaattg actcacggtt agctttacgc
      601 atctggtcta tagtccatac agactcatca aacttggcag tagcagttac tccatcaata
      661 attataggat aaccaccaat ttcaccattt accccaggag tatgtatttt gacttgtttt
      721 tcctctcgaa gagcagtaag aacagagaat atgatatcaa aattactgga agcattcatc
      781 atattgcgct tctgatctac aggcattgct atagaacagg atttaagaag ttcttcctta
      841 ttaaaatcca tatccttgcc ttgaaacttt atatcaagca agatgtcctg accttctgca
      901 tgaccttcct tagaaatgac aacatcatga aaatgtgata ccgcaatagt tacatcaatg
      961 tcattaaaat tctttatacc atatttctct gcaatataga attttatacg aggcacaaga
     1021 tgattcaaat taccactacc aaagtcaaaa taagccttac ccgcagactt tagccaagga
     1081 ataacagcat cggaatatga agtattgatt gagattgcct cacagttggc cttatcgtat
     1141 gcctccatta tattctttgc atatcgaata gaaagcggag tccaaatgcc gtatgcacga
     1201 agattactcc atgagatgct accatacttc aaaccagagt aaactcgact actatttact
     1261 atgaagtcag gcttttctgc ttcaagtaca gctgcaatgc tgttcacatc gttaaggtcg
     1321 cagttatcaa ccaccttaat ctcgctacgg cactggtgac gaatggttga agcagtacga
     1381 ataatattta tatccatctg catcttttcg gcattacgtc ctaccacaac aagacgaagt
     1441 tgtgaatcac ctagtgatac aagataatcc aacaagtagc atccaacgct acccaaacca
     1501 ataatcataa tagttattgg ctgactattt tcaaccttcc ctttgagaag ggaaagtttt
     1561 ctgttcagta tttccatttt aataaagtag aaaacgggtt tgtaataaat ttagaatcaa
     1621 caaatcgtaa tagaactgtt gtaaggacta atatgcaaac acagagaaac aaggcctggt
     1681 aaaaattaac ttgcaaatag gttgataata tgtgtgcaaa catgccttgt attacataat
     1741 atgctaaagt ctttgatcca taagcacata tcgacttggg gaggttcaca aacattaaaa
     1801 cagcgaatgt agtaataatt gatccaatat aaaccaatac tttcaaaaca agaagcattc
     1861 ctatattttg attgtacaaa tttgacatgt gccacacatt ggcattatta aactctaata
     1921 catgtagtat acgaccacta tagatgagac aaaaagcaaa acatactaaa gaggctatag
     1981 ccaaaacaag ctttatgcat tttgaaacat caggaataat aggcaggcct tttactcttc
     2041 tcaagaaacc catcataaag aatggtagaa acatacacga ccgttggaac gataacaggt
     2101 taccaaattg tttcaacgga agcatgtatg caaatacggc caacaagcaa ctgaatatca
     2161 ataactgccc cccgcaccca ttatattgta cgacaatttt gccaactagc ttattgataa
     2221 tcaacagaaa aataatatac caagttatta ggctgattaa ataccagcct gagttctccg
     2281 gatttagtaa agggatgata cttccataat aaaaacattg aggaatcatc acaaccaaaa
     2341 atgtttccaa aagcataata cctttactaa tcagtttttc tttatcctta acatttgcat
     2401 aataaccact gataaagacg aataatggca tatgaaaaat gtagattata gaatagagct
     2461 tattggcaat aggattgctt aaagcaggtt ctattacatg accgaatgta accaatacaa
     2521 tgagcaacca ctttattcca tctattctgt aatctctttc taatacagcc atattcattt
     2581 ttacatcaat tttcttacaa tatcataatc tgcaacagta ttgcagttga accagtcagt
     2641 gaaagtcact acatcatact cttcactatt catatcacta aagtaagcct gaattatttc
     2701 aagattagta ccttgaagtt gttcttttgt aagcgaatca acagtcttca aaagcctctc
     2761 agatgaagaa aatttccaca tctgaccact gttgaagatt gccttgaatg gctctgatac
     2821 agttaatgtc tgatgattcg tatcatataa ataccttggt ttgccatcaa cgttaatgta
     2881 taacgcaact gccttattcg agtagattgg ttctcggtta atggtaatca cactctttgg
     2941 cgaattatac acttgcctga aatctgtagc cataaagaac aagtcgcctt ctacgaaagt
     3001 cacatcacct gcctccttta ttgcctctat acctttgtat aaactgtagc cggagccata
     3061 gtctttgaaa tgctcgttgt aaacaagttc tatttttttg ccataaccag agagttcgtt
     3121 ctttacaaat cttcccaact tctcataaag gtagcccccc acaaggatat atttatcgta
     3181 ctcaccacaa ttcttcagca attgagcaag aagagcgtat tgaggttcat cggtataata
     3241 caagcatttg agggtttctt ccttagtgtc gcgattaaaa cgcgtagccg ttccagcaac
     3301 agttataatc aaatatttca tttcttgata ctatttacac acatcgtgag gccttcatcg
     3361 agagtgatga taggcttcca gctagtacgg gtacgaatct tgtccgtatt gagcaatcga
     3421 cgctcaggat cagactttcg gtaaccttcg aaacggatat ccacatcgtt gatgcccatt
     3481 tttattgcaa tcgtcttgac taaatcaata atggcaattt cctcttcagt agccacatta
     3541 taaacagtac catcaagagc atcctcagaa gcgatgagct ccataacggc acgacagcta
     3601 tcaatattat gaaggaaggt acgtttgttc accttcgagt tttcaagaag ggttacggta
     3661 tggctttcaa gcagattatc aatgatatga gggataatgt gctctgcaaa acgctcgtgc
     3721 ctgctatata cattagcaaa gcgaatagaa caacctttaa ttcgtccctt gccaacagca
     3781 tctttcataa agaattcagt catcaacttg ccgcaagcat aacttgtacg ttggctatgt
     3841 tccgctgttg acattgccaa ataatcagat tctttcacac cgccattctc attccaagac
     3901 tgcattgagt aaacctccga agttgaacaa ttaatgtaag tatcagccct catagaaatg
     3961 gcacgctcca agaaatcctt catagcaagg acgttagtct gaaaagtact ctctacctca
     4021 tagaaatgct ttgtatggac aacagcagca caattgataa acaccagacg gccatcgcac
     4081 tcaattttga gttctttcgc cttatcgcat acttcatcca tctgagcgac tttgttaatg
     4141 tcgtaattat agaagatgaa cgagggattg tcaataatgt ctttaacggt atcaatagaa
     4201 cttgcaaaga agttgtcgaa accgattacc gtatgaccct gagaaacaaa ctgacgagac
     4261 agttcactac ccgtcatgcc agtaacacca cttattacat ataagttctt catttatatt
     4321 ccaaatttta atcgttcgct gtaaaaagta tctatctctt tggggaaaag agattgttca
     4381 gcttcaatat cgtaaggaac tgcattgaaa tgggtttccc ccgttttaaa attgatatac
     4441 acatattgtg catatggatt ctgattgcga ggttgtccaa ctgaacctgg gttgataaaa
     4501 gtcgtacgtt tttgattgcg catgattgga ttgtcaactt tgaagaatac atctatctta
     4561 aaaggttgat gaatgtgacc gctcaatacg tagtcaaaat cctgatactt ttcatcttcc
     4621 acttttgctg gagtcagttt tccccaatag ggatcatcaa tagttccatg taaaagaagt
     4681 actttcttac caccaatttc caactcttgc attggctctt gcatcacatt gcttatataa
     4741 tcaatagatg tctgagtgag atggtttctt gtgtatttgg acatcacacg agctctttct
     4801 gaagagaaac atgagagttc cccatcaatc aaagccttct cgtgattgcc cttcaaattg
     4861 gcaagtaatg gaatattaac agtttgtata cgttcaataa tttcatttga acgcatacca
     4921 tagtcgataa agtcacctag actaatcatg gcatctggct gatagtgttt ctcaatatca
     4981 gctagaaccg cctcaaaagc agaaagattg gcgtgtatat cagcaaacag aattactttc
     5041 atactttact tgttaagaaa ttccataaaa gcctctttgt tctgaatagg agttgtagtt
     5101 ggacgaccaa ggtccttgcg gtttcccttt tttacgcaaa tctgaaggaa aacaggacct
     5161 tctgcgttct tgaattctgc aagttttgct tcaagtgcct ccatagtttc tacactataa
     5221 gcagccttgt aacctacagc ttgagcaatt gcacaaaaat caatcttgag accaacagta
     5281 ggctgaccac caacagaatc gtgtgcgcca ttgttgaaca caatgtgcac ataattcttg
     5341 catttcatgc tggctgtaat agccatatta cccatgtgca tgatgctggc tccatcacca
     5401 tcaaaacaat atactcgacg ctcaggcttt tggagagcta tgccgagagc tatctgggaa
     5461 gcatggccca tcgcccctac agtaaggaaa tcacgttcat gaccttggct ccaagcagta
     5521 cgtgcctcaa agagctcgcg agaaatcata ccagtagttg atacgataca agcattatct
     5581 tcaatgtttg aagccacctt ctgaatcgtc tcttcgcgag acattgccag ttcgtttacc
     5641 tcaacgctct gaagcttata ggtatcgaaa gtatccttct ctatcacaag ggcatagcac
     5701 tcgttggttg ccttcatgaa gtcgacagct atttttatct gctttgcagc tccctcttca
     5761 tcctttggca gaatagcata gttgataccc atggtattaa gcaaaccgat tgtcacctta
     5821 ccttgcttca catgctgagg ttcatcgtga actccagggc gccctctcca accgataacg
     5881 aggagcacag gaatgttata aacgtccttg tcggtaagag aggcaaacgg attaatgata
     5941 ttgccttcac cagagttctg catataaact acaggcacct tacctgttgc caaatgataa
     6001 cctacagcaa tacccatggc ccctccttcg ttagcagcaa taatattctg ctcagcagga
     6061 aggtggtcgg taatatatgc acaaatgttc ttgagcaacg aatcaggaac accagcataa
     6121 aagtctatac cttgttcctt gagtatattt acaaaaaatt cgggtcttac catttgtaaa
     6181 atagtttaag gggtaagaaa ttaatgttta cttcttcttt gtgcctggaa taagattaag
     6241 aatctgtttg ataggcatac agtactgctc agatgcttca agcgaacggc tagtatagag
     6301 gatggtttct gcacatttaa ccattgcagg ataagcagaa cgaagcatgt gattagcata
     6361 aatcactaca ttaatacccc attcagcaag ttcctcttct gtgaactggt tataagtagt
     6421 aggcacaacg atgataggag tatgagcatt cttctcgcga aagcgcaagc aaaactcctt
     6481 gatgtcctct ccagacttct ctttggagtg gatcattata ccgtcagtac ctgcctctac
     6541 gtaagcatga caacgctcca aagcatcatc tacagtctta ccagcaatga gagactcaca
     6601 acggctgaca atcatgaagt cacgagtaat ctgcgcctcc ttacccgcac ggattttagc
     6661 ctgaaaacct tcgattgtat cctgagtctg tacagcatca gtaccaaaaa gtgaattctg
     6721 tttcaagcct accttatctt caattataac gcaagagatt cccaagcgct caagggtgcg
     6781 aacggtaaaa ccgaagtgtt caatcttgcc accagtatcg ccatcgaaga taacaggttt
     6841 tgtggttact tcaagggtat cattgaggtc atggagacgg gtagtcaaat cgacagcctc
     6901 aatatcaggc ttacccttag aggtagagtc ggtaagggag gaagcccaca tgccatcgaa
     6961 ttcacgctcc tgaccattca cctctacctt agtatgttct gctatgaggc cagtaagacc
     7021 attgtgactt tcaagaatac gtacaatcgg tttagctgca ataaggcgac ggagagaaga
     7081 aagacgcatc tgaggagtta caccaagagc atcaatctct tgtttgatac cagaagcaga
     7141 gatgttttgg gtgtaaggaa tctcgataac ctcaccaccc aacttttcca ttactttgaa
     7201 tacctcatca cggatatact tgtcaggacc aacctgccaa tcatcaccat gaatgatgta
     7261 atcaggcttg tacttaagga gattagagac atagctccaa tcatcctgag ggaccaccct
     7321 tgatacgttc ctgatgctct caacaacgtt ctttctttgc tcccaagtga gataaggaag
     7381 tctacggtgg ttagcaatcg ccttatcagt gaacaaaccg attatcacat cgccatactc
     7441 agtagctttg ttaatgatgt taatgtaacc cggatgcatg atatcgccta tcataccaag
     7501 ataaactgtc tttgccatta ttatttaaca tttttcaaat tattataaag agcatctata
     7561 gtcaatcacc tcaatttctc ctgcttgaga ataagtatac tacacataga tagatttacc
     7621 ataagttcgg ctacacttct gaaccactca ataagtttct ccatttgcgg agagcaaagg
     7681 aactgtagga ctctaccatt gtgctaaaag aagaatggat ataccattga gttggagtaa
     7741 caatgatgat gcggaagttc tgtggctttc tgtcaattgc aacgaacact ccccattatg
     7801 agaagcatag ttataggttt caacaaaaag acaagcctta cttttgtccg caaacaagaa
     7861 cttgtctgta ttagagagaa tctcagtaag cactcaattt agggcatccc cctttgaaag
     7921 ggcacttttc agtgccctaa atgaaagtaa aaactttaca gatcttcact gctatacata
     7981 attctataaa ttgggtgggc agcgaagtta tcactttcaa ttaatagcca ttttttgact
     8041 gcttacagaa tctcaaaagc tcgtgatttc ttttattggt caatatacca tcaaagttag
     8101 atagtcttgc agtatgcgat ccccatattg tcgttattag cgaatccaag tttacgataa
     8161 attcgagaat aatataaatt cataatgtcg attttatctt ttatttctta cgaaattcat
     8221 tgatagcctg tgcaaagaaa acagttcgct tttgctcaag taatttcggt tcgtaattct
     8281 ttgaacgctc aaagttaatc tttgcctcaa actccatctt atctttgcta aagcctttga
     8341 ttatatttac taaagtatca atctctgtac catcgtaagt aaaaagcgaa tcaccatcta
     8401 tgagttctgg tataccacca acagaagagc aaatacaagg aacagccttg gtcatagctt
     8461 ctaagatggt acgagggaga ccttctgaac gactgggatg tacataaata tcaatagttt
     8521 cgaaccattt ttgaacatca tcatgcttaa actcgcctag aaattcaatc tgattagcaa
     8581 tccccaactc ggcagctaga ttgcgtagac gattaggttt acctgttcca accatttgaa
     8641 atatgtagtt ggtgaaacct tcggctttta gttttgccaa agccttgatg atagtatcct
     8701 gtcctttcaa ctctgtatct actgatccta cagttcccag tacaatcgtt ccctcttgct
     8761 tctgaatctt attcaaacgt tttgtcaatg acaactcatt aatatcaagg aactcaatat
     8821 ccgaacaacc aaggctcttg cctttgcatg ggtagttact ctgcagataa tcctgtgtaa
     8881 catagcaagc atagttagct tctcgaacca tgcgatgggt gtaataagaa agaggatagg
     8941 ctgacaaacg aaccaataga cgagaatggg caatcgtatt acggaatatg tcctcattca
     9001 ctactgccat atagggtata tgcttcttga gacaaatagt gctggcaaat gaggcagcaa
     9061 tgccactacg caaatagcag aaatctgcat ccttgagaac ccgtttcatc aagcgattga
     9121 tagcaagaag gttcttcgga ttacgaaact ccggtacctg cttgtaagtg atacgagggt
     9181 tagttacatc cttgtattta gccacctcct gagcacagtt acgattgatg atgcctgtat
     9241 atactgtcaa agtatcattc tcatttaagc ccgcaagaaa acgtgagaag aagtgctccg
     9301 atttggaatg atagaattgg ccattgtaat ggtcaatttc ctgatcttgt atatatatta
     9361 cgtccattac aagctattta agaatattca ataagttgtt ctagttcgat gtaggcttga
     9421 ttttcttttg aaaacaaaga aatacaacca agcataaaac aaaaccatta ctattaattc
     9481 aaatccaaag aataaatata tcaacacgaa aacacttcct gatatattta gcattgccac
     9541 attagaccgc tctgacactc gtacaattcc aataataaac aatagcgaga gtatacagcc
     9601 tagtagtcca aaatttgcta tatattctga ccagatatta acttggaagt tggaaccctc
     9661 cataaatgtc tctgcgtgtc cgttgtaggc ataggccgtt agataattaa aaaaaccata
     9721 tggcttatct tcccataaaa atcttggaat gtaacaagtt atatcatata aaagagtagc
     9781 accatcgtaa ggcagcatat ccgctccatt aagacggcta taaatagata atttcacctc
     9841 agactcacgg ctaaaatatg catcgtatgt ttcataaaaa ctatcatcag tatttttagt
     9901 tgtgaacata gaatatacag caaagtaggc tataaacaca caagaaagta acgcgccttt
     9961 ttttaccagc ttccaattag attgagtctg attttttata aaatctacta gtaatatacc
    10021 tacaattaga aaggccagca gacctctttt tccatctatc caaatacata tgacactaga
    10081 aagaagcatt ataatatttt tacttgtgct ccctttaatt aaataataat ataccagtat
    10141 cgatagaaaa gacagataga taatatacgg cattaccaat ctatgataca aatattctac
    10201 agccagtgga ttatacgaat gagtgtaaaa atacgaaaaa ttcgtgtaga tttcgggcgt
    10261 tggcgccaga ataactgcag ctactggagc gaacatcaac aacacaatac ataaacggta
    10321 aaagctattt atagcttttg tcctttgaaa cataatattt actcttttat gtgcaaactt
    10381 ttgtgctgtt gacgtcaatc ctaccattac aaaaatagca aacaaattat aaagatatgc
    10441 agtgttttca tcagtcagtg cattatataa atatttagta tgggtaccta atgaatttac
    10501 atcattgaac atatctacta ccagcggcaa tacttgaata ataaaaaaca gtatactaca
    10561 taggtgtagt atactatatc tattttttaa tactgccttt agtgatacaa atagataaaa
    10621 gaggtctatt attattgtta ttaatgtaaa aaatagtaac ataattaaaa acagctacta
    10681 ttattagcaa atattcttta cggtttctat atatctgctt atataatgct ccattgtaaa
    10741 atgttctatg aacaagtttc gaagtttctt agctttgact ttcaatattc cattttccaa
    10801 ctcataaatc attttgttga attgtgcttc ttggtctttt atgtctccat agttatacaa
    10861 gaaaatacca tactcctctc cgtacctttc gaagaatttg ttaccaccag ttctagacat
    10921 aagaatagga atcccctctc tcatgacttc taaagtaaca agatcaaaat acgtttcctt
    10981 attgggcaaa ataaaaatat ccgatgaaga taccaaacga ttaccatagt taatccaacc
    11041 taactctttc cagtttggat gatcaagtct ggttaatggt tcctcgtttc ctgctataac
    11101 aaactcaaat ctactatctt ttgacaagat atgctctgca aagagtttca gttggtcgta
    11161 acccttaatt tcattatgac gccccaaata gcatattaga tatttagagg aatctatacc
    11221 taattcttct ctatctagcg gttttgagat tggtttgtca agtatcgaac tctcgcaata
    11281 aatgaattta tcggtattgc aatccttata atcttttatc tctttttcta cataatatgg
    11341 ttcgagtgca ccttgcacag gaaacattat ataatccgct ttttcccatc cttgtaattc
    11401 tttcttcaaa atttgttttt ttattaatct tcgcaaaaca gaccacttat aaacaatatt
    11461 ctctacatcc tcacatgcct ttggttgcgg agaatgcgta gtcagtataa tcttaccttc
    11521 ataagaccta agaagttcag aagctctata caaatctcca gaattatgaa aatgaatagc
    11581 gtcaaaatca ttcagattta taccagatat agattttgca cttagtttct tattccaata
    11641 cattaagcat ctgaaggtgc gaaaataccc cataagtgag agaatatcca acttatgtat
    11701 tttcttcatc aagtccttat ggttagtatt tacagaccta tcaacattag gaatgcctaa
    11761 atcatccttc aaaaaatgta tttctgcatc tttagttgga tgcttcaaaa ggtattctct
    11821 aatattgtat aaatatccag caggacctcc agagtttttt aatacatagt tcaaatccca
    11881 tatcaacact tttttcatat actcaaatat tttcaatatt caacacttgc tcaatcacag
    11941 gagccatatc aaaatatcta tactggccaa ggcgaccgcc aaagataacg ccttcttctt
    12001 tttcagctaa cttgcgatac tctttagcaa gggcattgtt gcggtcatcg tttacaggat
    12061 agtatggttc cataccttcc tcgtattcgg ttgaatactc ttcgctaaca acagtctttg
    12121 gacaatcata aacttcctga ccaaacatct caaagtgctt gtgttcaatg acgcgagtat
    12181 aaagttcatc gtgactggta tagttcacaa cggcattacc ttggtagtta ggtgtatttt
    12241 ctacacgagt cttgaagttg acggtacgcc aatcaagctt acctaactta tagtcgaagt
    12301 actcatctaa agcaccagta taaacaagct tgctagcata gttcttccaa tccttgtact
    12361 ctgaattgaa gaaattgacc ccagtcttgc attccacacc ctcaagcaat ccttcgatga
    12421 gtttattgta gccaccgata ggaatacctt gataacaatc attgaagtag ttgttgtcaa
    12481 aaatcatacg aacaggcaga cgcttgatga taaatgtg
//
