LOCUS       c00460_gnlPro..        13991 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JDDFBJCG_460.
ACCESSION   c00460_gnlPro..
VERSION     c00460_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 08:45:54
            Original ID  :: gnl|Prokka|JDDFBJCG_460
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13991
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13991
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6793:12868]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      6794..12868
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13991
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13991
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(76..1284)
                     /locus_tag="ctg460_1"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEDLKEATRIENELFRKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDVDDLAHAIIKEKRFGFEEIAYLLLSGRL
                     PDKEELSSFRELINDNMPLEQKTKMNIIELEGNNIMNILARSVLEMYRFDPDADDTSRD
                     NLMRQSIELISKFPTIIAYAYNMLRHATHGRSLHIRHPQENLSIAENFLYMLKKDYTEL
                     DARTLDLLLVLQAEHGGGNNSTFTVRVTSSTGTDTYFTRMLNKEAYNKTGLIYGIGHAV
                     YTISDPRAILLKELARDLAREKGKEREFAFLELLEERAIDVFGRVKNNGKTVSSNVDFY
                     SGFVYEMIGLPQEIFTPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLDEVTYVPI
                     KKR"
     CDS             complement(1297..2457)
                     /locus_tag="ctg460_2"
                     /transl_table=11
                     /translation="MEKITVPFISGDGVGAEVTPSMQAVVNAAVRKSYGDRRGIEWKEV
                     LAGERAFHETGSWLPDETMEAFRTYKVGIKGPLTTPVGGGIRSLNVALRQTLDLYVCQR
                     PVRWYKGIVSPLKEPQKVDMCVFRENTEDIYAGIEWEAGTPEAEKFYRFLHDDMGVTKV
                     RFPETSSFGVKPVSREGTERLVRAACQYALEHHLPSVTLVHKGNIMKFTEGGFKKWGYE
                     LAECEFGKELAEGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLNGDYVSDQLAAMVGG
                     IGIAPGANINYKTGHAIFEATHGTAPNIAGKDIVNPCSIILSAVMMLEYLGWKEAASLI
                     ENALEQSFTEARATADLARFMPGGVSLSTSAFTREIVRRIENGNNE"
     CDS             complement(2461..4704)
                     /locus_tag="ctg460_3"
                     /transl_table=11
                     /translation="MVYDLTMLKTFYAAYSEKIERVRNVLQRPMTLAEKILYAHLYDGD
                     KVKNYRRGEDYVNFRPDRVAMQDATAQMALLQFMNAGREQVAVPSTVHCDHLIQAYKGA
                     KEDIATATKTNEEVYNFLRDVSSRYGIGFWQPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRLIGVHLKGKLSGWVAPKDVILKLAGI
                     LTVKGGTNAIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPYDERMGTYLKATGRE
                     EVAKMAASVAADLRADDEVLANPEKYYDRIIEIDLSLLEPYINGPFTPDAATPISKFAE
                     VVITNNYPRRMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLKVASPLIVNPGSEQIRA
                     TAERDGMIAAFEDIGATIMANACGPCIGQWKRHTDDPERKNSIVTSFNRNFAKRADGNP
                     NTFAYVASPEITMALTIAGDLCFDPLRDTLVNAKGEVVKLSEPVGEELPAHGFIGGKEG
                     YIAPGKGQTEITVNPHSQRLQLLTPFPAWDGMDLLNMPLLIKVQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNAFNGETNKVWNRSTNTYGTVSGTAKLYKSEGIPSIVVAEE
                     NYGEGSSREHAAMEPRFLNVRVILAKSFARIHETNLKKQGMLALTFTDKADYDKIRERD
                     LISVMGLKDFASGRTLKVVLHHEDGSKESFEVQHTYNEQQIAWFRAGSALNAR"
     CDS             4819..6732
                     /locus_tag="ctg460_4"
                     /transl_table=11
                     /translation="MITFATMKEQDSNSPIIHLQQQQLLLRMEYEYEKEEFKRQTENMG
                     IARKVKRGLCWYPATPGRSYYNSLNQLVIEITHTENTDIEHNFEFGRPVCFFRQSADGK
                     ITYMNFTATVSYADETRMVAIMPGAGAVMEVQETDNLGVQLYFDETSYRTMFEALEDTL
                     RSKGNRLAELRDILLGTSKAGFRELYPVRFPWLNSTQETAVNKVLCARDVAIVHGPPGT
                     GKTTTLVEAIYETLHREPQVLVCAQSNTAVDWISEKLVDRGVNVLRIGNPTRVNDKMLS
                     FTYERRFENHPLYPELWSIRKNLRELGSRARRGSYDEREGVRSRMSRLRDRATALEIQI
                     NAELFDGAHVIASTLVSSNHRLLNGRRFGTLFIDEAAQALEAACWIAIRKADRVVLAGD
                     HCQLPPTIKCHEAARGGLERTLMEKVVSNKPAVVSLLKVQYRMHEEIMKFPSQWFYNGE
                     LEAAPEVRYRGILDWDTPIHWIDTSEMDFKEEFVGETFGRINKAEADLLLSELKIYINR
                     IGGNRILEEKIDIGIISPYKAQVQYLRSKIKADASLKPYRSLFTVNTVDGFQGQERDVI
                     FISLVRANEEGQIGFLNDLRRMNVAITRARMKLVILGEAETLKHHGFYRKLLEFIQNIG
                     NQ"
     CDS             complement(6794..7837)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg460_5"
                     /sec_met_domain="IlvN (E-value: 3.9e-47, bitscore: 149.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.5e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIVMCLLSDAAVMS
                     VWPTIKPYLTPGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(7888..8640)
                     /locus_tag="ctg460_6"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVAAL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             complement(8637..9197)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg460_7"
                     /sec_met_domain="ALS_ss_C (E-value: 6.1e-20, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQES"
     CDS             complement(9230..10981)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg460_8"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.5e-48, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRQAAELI
                     NGAERPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNGAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             complement(11066..12868)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg460_9"
                     /sec_met_domain="ILVD_EDD (E-value: 9.7e-219, bitscore:
                     716.5, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQFVKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRKKLFEDAARLIVENAFRYYEEGDESVLPRSIATREAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGADFKMDDIDMLSRKTPCLCKVAPNTQKYHVQDVNRAGGIIAIMDELAKGG
                     LVDTNVHRVDGMTLAEAIDRYSITSSNVCKEAIKKYSSAAAGKFNLVLGSQNASYKELD
                     TDRATGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQDA
                     ACDGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIKDGDIIEIDIPNRSINVKLTDEELAARPMTPVTRNRE
                     VSKALKAYACMVSSADKGAVRLID"
     CDS             13357..13929
                     /locus_tag="ctg460_10"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYSIENGEKDFEEEAPVEHPFQFISGLGMTL
                     EPFEAQIKDLQIGDKFDFTIPASEAYGEYDDDHVIDLPKEIFMIEGEFDSDRVVEGAVI
                     PLMTSEGQRINGSVVEVKEDVVVMDMNHPLAGCDLNFTGEVVESRPATNEELAEVARMM
                     GGGCGSCGCGDCGDGCGDHECGGGCCH"
ORIGIN
        1 agaaaaaatc gttccaccat ggtggaacga ttttttctcc gtgatggaac gatttaaaag
       61 atacaagtct aatccttacc gtttcttaat gggcacataa gtcacctcat ccaaaacatt
      121 cttataggca ggacggataa tacgcttacc ttcaaagttc aattcttcat tgcgatgtgc
      181 acaccaaccg acaatacgtg ccatagcaaa caaaggcgtg aagatttcct gcggcagtcc
      241 aatcatctcg tagacaaagc ccgaatagaa atccacatta ctcgaaaccg tcttgccatt
      301 attcttcaca cggccaaaca catcaatggc gcgctcctcg agcagttcaa ggaaagcgaa
      361 ctcgcgttct ttcccttttt cgcgggcaag gtcgcgggca agctctttca gcagaatggc
      421 gcgcgggtcg gaaatggtat agacggcatg tccgatacca tatatcaagc cggtcttgtt
      481 ataggcttcc ttgttgagca tgcgggtgaa gtaagtatcc gtcccggtag aagaagtgac
      541 acgtacggta aaagtggagt tgttaccacc accgtgctcg gcctgaagaa ccagcagcag
      601 gtcgagcgtg cgggcatcca gctccgtgta gtccttcttc agcatataga ggaaattctc
      661 ggcaatggaa aggttttcct gcggatggcg gatatgcagt gaacggccat gggtggcatg
      721 gcgaagcatg ttataggcat acgcaatgat ggttgggaat ttcgaaataa gctcaatgct
      781 ctgccgcatc agattatcgc gggaagtgtc atcggcatcc gggtcaaaac gatacatctc
      841 gagcacgctg cgcgccagga tgttcataat gttgtttcct tcaagttcaa tgatattcat
      901 cttggtcttc tgctccagcg gcatgttatc gttgatgagt tcacggaaag aagagagttc
      961 ttccttgtcg ggcaggcggc cggaaagcag caagtaggca atttcctcaa aaccgaaacg
     1021 cttctctttg atgatggcgt gtgccaagtc atccacatca taaccgcggt agaacaattt
     1081 gccgggaata ggcttcagcc ctccaccggg gatgcgttca tagccaacca cattgcctat
     1141 tttggtcaac cccaccaaga ctcccgtgcc gtcctcatta cgcaaaccgc gcttcacatc
     1201 aaacttcctg aacagttcat tctcaatccg ggtagcttcc ttcaaatctt cggaaagctt
     1261 gtaaatcaga tactccttct tcataatcgt ttcgttttat tcgttattcc cattttctat
     1321 tctccttaca atctcccggg tgaaagccga agtggacagc gagacgccac ccggcataaa
     1381 acgggccaag tcggcagtag cacgggcttc tgtgaaactt tgctccaagg cgttctctat
     1441 aagagaggct gcttccttcc aacccagata ttcaagcatc atcacagcgg aaaggatgat
     1501 ggaacaggga ttcacaatgt ctttcccggc aatgttcgga gccgtcccgt gagtagcctc
     1561 aaaaatggca tgccccgttt tatagttgat attcgcaccc ggtgcaatgc cgatgccgcc
     1621 taccatggca gccagttggt cggacacata atcgccgttc agattcaacg tggcaatcac
     1681 ggaatattct tcggggataa gcaacgtgtt ctgcaagaat gcatcggcaa tgcagtcctt
     1741 gatgaccaga cgcccttctg ccagctcttt accaaactca cattctgcca gctcgtaccc
     1801 ccacttcttg aaaccgcctt ccgtaaattt catgatgttt cctttgtgta ccaaggtcac
     1861 ggaaggcaga tgatgctcaa gcgcgtattg gcaggcggca cgcaccaagc gctctgttcc
     1921 ttctcttgaa acgggcttca cgccaaacga ggaggtttcg ggaaaacgga cttttgtcac
     1981 ccccatgtca tcatggagaa aacgatagaa cttttcagcc tccggagttc cggcttccca
     2041 ttcgatgcct gcataaatat cctcggtatt ctcacggaat acgcacatat ccaccttctg
     2101 cggctctttg agtggagaaa caataccctt ataccaacgt accggacgtt ggcagacata
     2161 caaatcaagc gtctgacgca atgccacgtt caacgaacgg atacctccgc cgacaggtgt
     2221 tgtcaaagga cctttgatgc ccaccttata agtgcggaag gcttccatcg tttcatccgg
     2281 cagccaggag ccggtttcgt ggaaagcacg ttctcctgcc agcacttctt tccattcaat
     2341 gccacgccgg tcaccatagg atttcctgac agcggcattc acgacagcct gcatggatgg
     2401 ggtcacttct gctcccactc catcgccgga aataaaaggt acagtaattt tttccatatt
     2461 ctatcttgca ttaagtgcag aaccggcccg gaaccaggct atctgctgtt cgttatacgt
     2521 atgttgtact tcaaaacttt ctttactccc gtcctcgtga tgaagaacca ccttcaacgt
     2581 acgtcccgaa gcaaaatctt tcaaccccat gacagaaatc aggtcgcgtt cccgaatctt
     2641 gtcataatcg gccttatccg taaaggtcag tgccaacatg ccttgtttct ttaaattcgt
     2701 ctcatggata cgggcaaagc ttttcgccaa aatgacgcgt acattcaaga agcgtggttc
     2761 catggcagca tgctcacggc tggacccttc accataattc tcttcggcaa cgacaatgga
     2821 agggatgcct tctgatttat acagcttcgc agtgcctgac actgttccat aggtattggt
     2881 ggagcggttc caaaccttgt tcgtctctcc attgaaagca ttgacagccc ccatcagcat
     2941 attgtccgaa atattctcca aatgtccccg gaaacggagc catggccccg ccatagagat
     3001 gtggtcggtg gtacatttcc cttgcacttt aatcaataaa ggcatattca gcaagtccat
     3061 gccatcccag gcagggaagg gagtcagcag ttgcaagcgc tgtgaatgag gattgaccgt
     3121 aatttccgtc tgtcctttgc ctggagcaat gtatccttcc tttcctccta taaacccgtg
     3181 tgccggcagt tcttcaccga ccggttcgga cagtttcaca acctctcctt tggcattgac
     3241 cagcgtatcc ctcaacgggt cgaaacaaag gtcaccggca atggtcagcg ccatcgttat
     3301 ctccggggaa gcgacgtaag caaaagtgtt gggatttcca tcggcacgtt tggcaaaatt
     3361 acggttaaaa gaggtgacga tggaattttt tcgttcaggg tcatcagtat ggcgcttcca
     3421 ctggccaata caaggtccgc aggcattcgc cattatcgtt gcgccaatat cttcgaaagc
     3481 ggcaatcatg ccgtcgcgtt cagcagtggc acgtatctgc tccgaaccgg ggttgacaat
     3541 cagcggagaa gcaaccttca aattcttttc ctttacctgc cgggcaaggg aggctgcgcg
     3601 gctcaaatcc tgataggacg aattggtaca cgaccctatc aggccgactt ccatccggcg
     3661 gggatagtta ttggttatca ctacctcggc aaatttcgat atcggtgttg ctgcatccgg
     3721 cgtaaagggc ccattgatat acggttccaa cagcgagagg tctatttcaa tgatgcggtc
     3781 gtaatatttt tccggatttg ccagcacttc gtcgtcggcg cgaaggtcgg cagctacgga
     3841 agcagccatt tttgccactt cttcacgtcc ggtagccttc aaataagtac ccatgcgctc
     3901 atcgtaaggg aaaagggagg tagtcgcccc cacctctgcc cccatattgc agatggtagc
     3961 ctttccagtg gcagacaatg aagcggttcc cggtccaaaa tattcaatga tggcattggt
     4021 tccccctttt acagtaagaa tacccgccaa cttcagaata acatctttgg gagctaccca
     4081 gccactcaat ttacccttca agtgtacgcc tatcagacgc ggcattttca attcccattc
     4141 catgccagtc atcacatcca ccgcatcggc accacccaca ccaatggcca ccatgcccaa
     4201 acctccggca ttgggcgtat gagagtccgt gcctaccatc attccacccg gaaatgcgta
     4261 gttctccaat accacctggt gaataatgcc tgctcccggc tgccaaaaac ctatgccata
     4321 gcgggaagaa acatcacgga gaaaattata gacctcctcg ttggtcttcg tagcagtcgc
     4381 gatatcttct tttgcacctt tatatgcttg aatcaaatgg tcacagtgca cagtggaagg
     4441 cacggcaacc tgctcacggc ctgcattcat aaattgcaat aaggccattt gggccgttgc
     4501 atcctgcatg gccacacggt cgggacggaa attcacatag tcttctcccc gtctgtagtt
     4561 cttcacttta tccccatcat acaaatgagc atacaaaatt ttctccgcta aagtcatcgg
     4621 acgctgtagt acattccgta cgcgttctat cttctccgaa taagcggcat aaaacgtttt
     4681 gagcatcgtt aaatcatata ccataaccac tattttttag tttttcatta ttgtaaagat
     4741 tacaaattaa tatcataaac aaataaaaag gctgaatagt ttaacaaaat aaagcatttt
     4801 ttccgtcgga agtgaagaat gattaccttt gcaaccatga aggaacaaga ttcaaatagt
     4861 cctattattc acctccagca gcaacaactt ttgctgcgca tggaatacga atacgaaaaa
     4921 gaggaattca aacgccaaac cgaaaacatg gggattgccc ggaaagtgaa acggggactt
     4981 tgctggtatc ctgccactcc gggacgaagt tactataatt cactgaatca attagtaata
     5041 gaaattacac acacagaaaa taccgatata gaacataatt ttgagttcgg ccgtcccgta
     5101 tgttttttcc gccagtctgc cgatggaaaa ataacctata tgaacttcac cgctaccgta
     5161 agctatgccg acgagacacg gatggtagcg ataatgcccg gagccggtgc cgttatggaa
     5221 gtgcaggaaa cggacaacct cggcgtgcaa ctttatttcg acgaaacatc ctatcggacc
     5281 atgttcgaag ccttggaaga tacgttacgc tccaaaggca accgcctggc cgaattgcgg
     5341 gacatattgc tgggaacctc gaaagccggt ttccgagagc tctaccccgt acggtttccc
     5401 tggctgaact ccacgcagga gacagctgta aacaaagtgc tgtgtgcccg cgacgtggcc
     5461 attgtacatg gtcctccggg aaccggaaaa acgaccacct tagtggaagc catctatgaa
     5521 accctgcatc gggaaccgca ggtactggta tgtgcccaaa gcaatactgc cgtcgactgg
     5581 atttcggaaa aacttgtgga ccgtggcgtc aatgtcctgc gtatcggcaa tccgacccgt
     5641 gtcaacgaca agatgctttc ctttacctac gagcgtcgtt tcgagaacca tccgctttat
     5701 ccggaactgt ggagcatccg gaaaaatctc cgtgaactgg gcagccgtgc ccgccgtggc
     5761 agctatgacg aacgcgaagg agtacgcagc cgtatgagcc gcctgcgcga ccgcgccacc
     5821 gcattggaaa tacaaatcaa tgcagagctt tttgatgggg cacacgtcat agcctccacg
     5881 ctggtaagca gcaatcaccg gctgctgaac ggacgccgtt tcggcaccct tttcattgat
     5941 gaagcagccc aggccttaga ggctgcctgc tggatagcta tccgaaaagc agaccgcgtg
     6001 gtattggcgg gtgaccactg ccaacttccg cccaccataa aatgccacga agccgcccgt
     6061 ggaggtctgg aacgaacatt gatggagaaa gtggtgtcca acaaacctgc cgttgtctct
     6121 ttgctgaaag tgcaataccg catgcacgag gaaatcatga aatttccttc ccaatggttt
     6181 tataatggcg agttggaagc cgctcccgaa gtgcgttacc ggggcatcct ggactgggat
     6241 acccccatcc actggattga cacctccgaa atggatttca aagaagaatt tgtgggagag
     6301 actttcggac gcattaataa ggcggaagcg gacctgctcc tatcagaact gaaaatctac
     6361 atcaaccgta tcggtggcaa ccgcattctg gaagaaaaaa tagacatcgg catcatctcc
     6421 ccttacaagg cacaagtgca atatctccgt agcaagataa aggcagacgc ttcactcaag
     6481 ccttatcgca gcttgttcac tgtaaatacg gtggatggct tccaagggca agagcgcgat
     6541 gttatcttca tcagccttgt ccgtgccaac gaagaaggac agataggatt cctgaatgat
     6601 ttaaggagaa tgaatgtagc catcacccgg gcacgtatga agctggtgat attgggagag
     6661 gcagagacgc tgaaacatca cggtttttac cggaagctat tggagtttat tcaaaatata
     6721 gggaatcaat aataaagaaa taccccctcc ggtaacaccg aagagggtat ttcacctatt
     6781 tatataaagc tgattaattg ttttccggac gaagtttacg aactgtaaca gctgtctgcc
     6841 acatttcgct ttcacgcaag gctttcaatt ctgcattcag cttctcacga taatcgggtt
     6901 tggagttact gtcgatagaa atctgggctt cgttgcccga cttcacactt gcatacaatt
     6961 tctgtacaac cggcttgatg gcatcatgga acggggtcat ccaatccagc gcaccacgct
     7021 gtgccgtagt agaacagttg gcatacatcc agtccatacc gttcttggca aacaatggca
     7081 tcaaagattg agtcaactct tccactgttt cattgaatgc ttcagaagga gtatggccgt
     7141 tttcgcgcaa tacttcatac tgagccaaca gtaatccctg gatagcaccc atcaatgaac
     7201 cgcgttcacc ggtcaagtcg gaagtggctt cgcggatgaa agttgtctcg aacaaatatc
     7261 ccgaaccgat accgataccc agtgcaatcg tcttgtcaaa agccttaccc gtagcatctt
     7321 gatagacggc atatgatgag ttcaagccac gcccttcgag gaacatggta cgaagtgaag
     7381 taccggaacc tttgggagca accataataa catcaatatc tttaggagga accacgccgg
     7441 tacggtcgtt ccaggtaata gcaaaaccat gagagaagta aagagccttc ccgggagtca
     7501 aataaggttt gatagtcggc catacagaca ttacagctgc gtcagacaac agacacatga
     7561 cgatagtacc tttctgacaa gcctcttcga tgccgaacaa agtctcaccc ggtacccatc
     7621 cgtcagccac agccttttcg tatgtcttac ccggacgttg tcctacaatc acattgaaac
     7681 cgttatcacg caagttgcaa gcctggcccg ggccttgtac gccataaccg attactgcaa
     7741 ttgtttcatc tttcaaaatc tcacgtgctt tttccaaagg aaattcttcg cgggtcatta
     7801 cattctcaat aacaccgcca aaattcaatt gtgccatttt ttgttttaat ttttatttgt
     7861 ggcttacgcc aacgttgata aatttattta tttctctgta aatatcactt tagaacgaca
     7921 gaccacttcg ctgccattct ttttcacctc cacatcgtaa acgccctcac cggcatcatc
     7981 catgaacaaa gtcaactcat ccccataata gctttcggct acatatgcca tttcaaaacg
     8041 acggatgcgc ttctccttat acatctctat cgggaacaaa tcaaggatat gctcgatgta
     8101 acggatgctg ttcacatgcc cgttaatgtc aatatcactg tatttggcta ccaaagcagc
     8161 aaccggttcc tttgaggcca cctttatccg cgaaggtttt tctatcgggc aaggctcatc
     8221 gcaaacataa tctacaatgc tgccactatg aagagccagc aaatctgccg gcttacgggt
     8281 attcatgcta atcatcgccc aaacggaacg tgcataccca atcttcttac cctccttatc
     8341 gatgatagcg aaattacggt ctgtaaaaag gcgatagaca ttctccaccc aagtctgaat
     8401 ggagaaatct tcgtactgat aaggcatttc atccagttcg acagccagac gggacaatac
     8461 ccaagtataa ttgtcctcgt ttagagtcgc gatgccaaaa ccgcggtcgc tggcatggaa
     8521 acccgcacaa ttcaacaaat ggttgcccaa tactcccatt gtcagccgtc cggtaaagtc
     8581 gacatgaaac ggttcggcaa caaacttgta ggtacctatc ttattgttct cgctcatcat
     8641 gattcctggt gtttactttg acgatatttt gcttcacggt ccgccagata ttcattgaca
     8701 cgctcaaagc agctggtcgt aatggctacg cgacccgaac ggacgaactg aagtacgcaa
     8761 tccaactggc gcaactcctc ataaagattg gttatttcct cactcatgcc attcttctca
     8821 acaatggcaa atacagcatt cacctccaca atacgggcat tgtacttacg gattactttg
     8881 gacacctccg gtttttcttc cagcgtaggg gtcgttattt tatagagagc aatctcgtgc
     8941 tgatagattt catcatccgt aaaataatgg gcttgcagca catctatttt cttggtaatc
     9001 tgcttggtca ccttttcaat ggtatccttg tccgtccaag cggtaatggt atatttatgt
     9061 acccccttga tggaggaggc cgatacattt aaactttcga tgtttatctg ccgacgggta
     9121 aacacagccg tcacttgatt cagcaaaccg gcaaagtttt ccgaatgaac aatgattgta
     9181 tatagttttt tatccataga tagagtaaat tctttaattt cgcatgactt cagcattcca
     9241 acaacatctg attgaccgaa ccgcccggag gtgtcatcgg cattacattt ccttcttcct
     9301 ccacacaagc ttcgagcagg aacggtccgt cggttgctat catctcgtca atcgcttttg
     9361 ccagctcctc gcgggtcatt accctgcgtg caggaatatc atatgccgaa gcaatcttca
     9421 tataatccgg attcatcatc ggagtaaacg aataacgacg attgaaaaac atcgcctgcc
     9481 attgacgaac attgcccaag aagttattgt tcaacagaat catcttcacc ggagcctttt
     9541 gttccatgat ggtacccagt tcctgcaggt tcatctgcaa gccgccgtct cccatgaata
     9601 cgcataccgt gcggtccgga cgtccaaaag tggcaccgat agctgccgga aggccgaagc
     9661 ccatagtacc caggccaccg gaagtaacaa tgctacgttc cttgctgtat ttgaaataac
     9721 gggcggacat catctgattc tggccgacat cagtcaccaa tatcgccccg ttatgggtag
     9781 cctcactcac agcacgcacc acctcaccca tgcttagcgc ttttcctgcc ggatgtaatt
     9841 ccggacggat taccttttcc tcttccactt cctcgtattg ccggaaactg tcaatccatt
     9901 cctgatggtt ggcgggttcc agcaattggg taacggcagc cagtgtctct ttgcaatctc
     9961 ccaggacagc aacatcggtc tttacattct tatctatttc ggcagggtca atatcaaagt
    10021 ggataatctt cgcctgcttg gcatatgttt ccaatttacc cgtcacacgg tcatcaaagc
    10081 gcatgcctac ggcgataagg acatcacatt tattggtatt gatattgggc cccaggttac
    10141 cgtgcatacc aagcattcct ttgttcaacg gatggttcgt aggtaatgcg gaaagtccca
    10201 ataaagtgca tccggcaggc attccggctt tctcaatgaa agcacgaagc tcttgctggg
    10261 cttctcccag ctccacgcct tgtcctacca gcaccaaagg ccgttccgca ccatttatta
    10321 attcagcagc ctgccgtatg gcctccggct ccatttcggg aacgggaaga tagctacgga
    10381 catagtccac cttagtaggc gcatattctg ttttctccac ttgggcgttt ttagcaaaat
    10441 ccagcacgac cggtcccgga cgtccgctct ttgccacata gaaagcacgt gccactgccc
    10501 aggccacatc ttctgcacga cgaatctggt aactccattt cgtgataggc tgagtaatgc
    10561 ctaccaagtc cacttcttga aatgcatccg tacccaagaa gttcgtccct acctggccgg
    10621 caatgacaac gataggcgta ctgtcaatca tggcatctgc aatgcccgtg atagtattgg
    10681 tagcacccgg tccactggta accagacaaa cgccaacctc gcctgataca cgtgcaaagc
    10741 cttgtgccgc atgggttgct ccttgttcat ggcgaaccaa gatgtggttc aattccttcc
    10801 ggtggtcgta taaggcatcg aataccggca tgatgctccc tcccggataa ccgaaaatag
    10861 tctttactcc ctgatgctcc agagagcgca tcaatgcttc tgcgcctgtt attagagcct
    10921 caccccgacc ctctccttgg gagagggagg aaaagttact ctttttatta ttatcagcca
    10981 tactttatct ttttattaaa aacttcggaa atttgtatca ttccctcctc ccctctcttt
    11041 cggagagggg tcgggggtga ggcctttaat caatcagcct cacagcccct ttgtcagcgg
    11101 aactcaccat acaggcatat gctttcaatg ctttggagac ttcacggttg cgggttaccg
    11161 gagtcatagg gcgtgctgca agctcttcat ccgtcaactt cacattgata gaacggttcg
    11221 gtatatcaat ttcgataatg tccccatcct taatcttgcc gatattacca ccggcagccg
    11281 cttcgggaga aacatgtccg atgcttagtc cggaagtacc accactgaaa cgcccgtcgg
    11341 taatcaatgc acactcctta cccagatggc gggatttgat ataagaagta ggataaagca
    11401 tctcttgcat acccggtcca cctttcggcc cttcgtgagt gatgacgacg acgtctccac
    11461 tgaccacctt tccacccaga ataccgtcgc aagccgcatc ttgtgagtcg aagactttcg
    11521 ccggccccgt aaatttccag atactctcgt ctacaccggc agtcttgaca acgcaaccgt
    11581 cctgagctat atttcccttc aaaaccgcca gaccgccatc cttgctgtat gcatgttcca
    11641 aatcacggat acaaccggtc gcacggtccg tatcgagttc cttataagac gcattttgtg
    11701 agccgagtac cagattgaac tttccggctg ccgcactgga gtatttcttg attgcctctt
    11761 tacatacatt agagctggta atactatacc ggtcgattgc ctctgccaac gtcattccat
    11821 ccacacggtg gacattcgta tcgaccaatc cgcccttggc aagctcatcc atgatggcaa
    11881 tgatgccacc ggcacggtta acgtcttgta catgatactt ttgggtattg ggagccacct
    11941 tgcataagca gggggtcttg cgggagagca tgtcaatgtc gtccatctta aaatccgctc
    12001 cggcttcgtg agccacagcc aacaaatgaa gtaccgtatt agtggaaccg cccatcgcaa
    12061 tatccagcgt catggcattc aaaaatgcct cgcgggtagc aatactgcgc gggagtacac
    12121 tctcatcccc ttcttcataa tatctaaagg cattctctac aatcaacctg gctgcatcct
    12181 caaatagttt cttgcgattt tcgtgagtgg ctacaatcgt gccgttaccg ggcagtgcca
    12241 atccaatcgc ttcattcaag caattcatgg aattagcggt aaacatgcct gagcagcatc
    12301 cgcaagtggg gcaggcatgt tgctcaatct gtgccacctc tttatcgccc acactttcat
    12361 cagcagattt aatcatggca tcaatcaaat ccaaatgttg tccgttccat tccccggctt
    12421 ccatcggacc gcctgaaaca aacacagtcg gtatattcag cctcatagcc gccatcagca
    12481 tccccggagt aatcttgtca cagttactga tgcaaaccat agcatctgcc ttatgggcat
    12541 ttaccatata ctccacacta tcggcaatga tatctcttga aggcagggaa taaagcatac
    12601 cgtcgtgtcc catagcgata ccgtcgtcaa tggcaatcgt attgaactcc gcagcaaaac
    12661 accccagttt ttcaatctct tcctttacaa actggcctat ttcgtgcaga tgtacatgcc
    12721 cggggacgaa ttgtgtaaat gaattgacta tagcgataat gggcttaccc atctgttcct
    12781 tcttcatacc attcgccgtc cacaatgcac gggctcccgc catgcggcga ccttgtgtgc
    12841 tgaacgagct gcgtaactga tgcttcattt tcaaatctcc ttttaatgaa aaagcctctc
    12901 ccactatagt gagaaaggct taataaatta tcttctaacg tacgaataca tacataacct
    12961 ttctcacgct cttgatgcca ccaccacgac gcgaataata tgcaggactg ccaggttaat
    13021 agatgtatgt aaattcataa cttaattctt cttttttgtt tcaaacgtgc tgcaaaggta
    13081 agggcttttt tataatctcc aaacaaattg aagaaaaaaa taagataaat atgaataatc
    13141 gtaagaaaat atcgccctaa aatcctattt tatcacttaa cagttctaaa tagcaccatt
    13201 cagacagcca atgtaaatgt attgccaatc attgaaacca tttaataatc tgaaaattac
    13261 caaaggctct ctacatcccg aaacaaataa ttcgtatctt tgtctcttca aatactcaaa
    13321 aaaagtattt actaattaaa taaagataga aaattaatgg aaacagtaga aaacaagtac
    13381 atcaccgtag catataagct gtactcaatc gaaaacggag aaaaagattt cgaagaagaa
    13441 gcacccgtag agcatccttt tcagtttatc tcaggtctgg gaatgacact cgaacccttt
    13501 gaagcccaga taaaagactt gcagataggc gataaattcg actttaccat tccggcatca
    13561 gaagcttatg gtgaatatga cgacgaccat gttattgacc tccccaaaga aatcttcatg
    13621 atagaaggag aattcgacag cgaccgtgta gtggaaggcg ccgtcatccc cttgatgact
    13681 tctgaaggtc aacgcatcaa tggaagtgta gtagaagtaa aggaagacgt agttgtaatg
    13741 gacatgaatc atccactcgc aggttgtgat ttgaacttta ccggagaagt ggtggaaagc
    13801 cgcccggcta cgaacgaaga gcttgctgaa gttgcccgta tgatgggtgg cggttgcggc
    13861 agctgcggtt gtggtgactg tggcgacgga tgcggcgacc atgaatgtgg aggtggatgc
    13921 tgccactaaa gaattaagaa ttaaaaatta aagaattaaa aattaaagaa tcagactaca
    13981 cagtattaag c
//
