LOCUS       c00474_gnlPro..        17023 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PPNKKEPM_474.
ACCESSION   c00474_gnlPro..
VERSION     c00474_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 11:23:05
            Original ID  :: gnl|Prokka|PPNKKEPM_474
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17023
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..918)
                     /locus_tag="ctg474_1"
                     /transl_table=11
                     /translation="MIHNVKILFFICFFTACSSTEQKEIVTAGELLRQAAFYGERLQFL
                     PALETYQQAIKLAEKEKDSTVFSLAYLEMGKIYRYQSLKQKALQSEKKALSYIKSPACD
                     SLRLELYREIGDMYTLSGQADSAFHYYEMAGCRIKQAKILQQNGSNKEAETLLKTELEQ
                     TIFPKEKAEVCLALADLQITLGKLDEAEKSLSQVPPSHPHLYAALSRIAQSRGDSLQAD
                     FYHKSYLHHLSVLRQEKEQNQITQLLRTSEQKEWEKRLTDSQKAQKEQIYVWVTLLVSC
                     STGIWGYSRYRQKRNVVSLSETDFF"
     protocluster    1..17023
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4682:8122]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4683..8122
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..17023
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..17023
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(1030..1998)
                     /locus_tag="ctg474_2"
                     /transl_table=11
                     /translation="MMLKKKSNNWARLKLALLVPVGFAALSAFARPETSPPPAATMTDN
                     IHLSINKSTVNQETMQQDHAVFLTYKESGSEDLNSIVCKTLDRIRTRVAEGQFKNALEV
                     TVNPAFDDIPASYLETVKDVLEERDIKCKIDMTVPNTIMDDVAKPYRKYDDVVYLIQNK
                     KIVAALSISKFSANQNDPRLDKISKSASLILQPENPKVSRQEMEKLKNLLDKKGLTSEI
                     NMNIFKIGDAAAPPPPPPAGQVIFSYRDGQPDQQFVLYDRHAKPGANLGQRIDKIYKDN
                     ITKVSIKINKSTPKDLLETVKQELKKKINYPVQYEILQFVD"
     CDS             complement(2166..2798)
                     /locus_tag="ctg474_3"
                     /transl_table=11
                     /translation="MDAFLLYILKSGICLTVFYVCFKALFSNDTFFRFNRWILLVGTGV
                     CMLLPLCRIQTARPFPLSRPVSQLEIVFYEEEMKAFPVPESKEEITIPTEQRNISVPWT
                     GIIGIAFLTGSGICLTTTILSFGKMYQLTRKNRKLKQGKYTLILTPDPVSPFSWGRYIF
                     LSENDYRNHPNEILMHEKMHLRYNHSVDLIYMKRFFFCNGLILPYGY"
     CDS             complement(2812..3168)
                     /locus_tag="ctg474_4"
                     /transl_table=11
                     /translation="MVRLTSKEEEILGYFWAKGPLFVRELLDLQEESKPHYNTLSTIVR
                     SLEEKGYIGYKVYGNTHQYYALVSEDEYRRNSLKQVISKYYDNSYTRVVSTLIEEEVLT
                     IDELQKLIQQIKNK"
     CDS             3328..4359
                     /locus_tag="ctg474_5"
                     /transl_table=11
                     /translation="MKIGTIDLGERPVFLAPMEDVTDISFRLMCKRFGADMVYTEFVSA
                     DALIRSVNKTQQKLNVADEERPVAIQIYGRDVPTMVEAAQICEAAHPDILDINFGCPVK
                     RVAGKGAGAGMLRNIPLMLDITREVVKAVNIPVTVKTRLGWDADNRIIVDLAEQLQDCG
                     IAALSIHGRTRAQMYTGEADWTLIGEVKNNPRIQIPIIGNGDVTSAEICKQRFEQYGVD
                     AVMIGRGSIGRPWIFREVRHYLDTGETLPAESFSWYLDILKKQVEQSVERLDERRGILH
                     IRRHLAATPLFKGIADFKQTRVAMLRAETVEALFDILDSIPDKFHTGYGFQSDSQVSES
                     IDC"
     CDS             complement(4332..4490)
                     /locus_tag="ctg474_6"
                     /transl_table=11
                     /translation="MKKTHCKYKVYLLNTQEFVITFYCKFATFCFKIDTVCGFTLLLYQ
                     QSIDSDT"
     CDS             complement(4487..4672)
                     /locus_tag="ctg474_7"
                     /transl_table=11
                     /translation="MYVYGKARRQWQRAFFMFVQTHKKAALPIIKVDAAFLLLSSETVS
                     RFPLCKDFVNLRSKIL"
     CDS             complement(4683..5438)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg474_8"
                     /sec_met_domain="Fer2_3 (E-value: 1.1e-26, bitscore: 83.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 3.1e-12, bitscore: 36.8,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 3.3e-06, bitscore: 17.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKDIKVTLKVWRQKGPKDKGQFETYQIDKINQSVSFLEMLDILN
                     ERLVSEGKEPIVFDHDCREGICGMCSLYVNGHPHGPATGATTCQLYMRRFNDGETITIE
                     PWRSAGFPVIRDLMVDRYAYDKIIQAGGFVSVNTGGVPDANAIPISKADADLAMDAAAC
                     IGCGACAAACKNGSAMLFVSAKVSQLALLPQGKVEAARRAKAMVAKMDELGFGNCTNTR
                     ACEMECPKNISVSNIARLNREFISAKLQD"
     CDS             complement(5466..7409)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 194.4; E-value:
                     1.1e-59)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg474_9"
                     /sec_met_domain="FAD_binding_2 (E-value: 2.6e-60, bitscore:
                     194.4, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.7e-38,
                     bitscore: 121.5, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQIDSKIPQGPLAEKWTNYKNHQKLVNPANKRRLDIIVVGTGLA
                     GASAAASLAEMGFNVLNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKG
                     GDYRAREANVYRLAEVSNSIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARGQT
                     GQQLLLGAYSALSRQIGLGKVKMYTRHEMLDVVKVDGRARGIIARNLITGKIERFAAHA
                     VVVATGGYVNTFFLSTNAMASNGSAAWQCYKKGAYFANPCMVQIHPTCVPVKGDFQSKL
                     TLMSESLRNDGRIWVPKKLEDAKALQAGTKKGKDIPEADRDYYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNSTGLAVFLDFSDAINRLGKEVVKQKYGNLFDMYEEITNDDPYE
                     TPMMIYPALHYSMGGLWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYF
                     VLPYTIQNYLSDQIQVPRFSTDLPEFVEAEKAINARIAKLMNVKGKETVDSIHRKLGHI
                     MWEHVGMARDAEGLKEAIQMLKDLKKEFWSNVFIPGEANSLNVELDKALRLADFIEIGA
                     LMAHDALDRAESCGGHFRTEHQTEEGEAMRHDDKFMYVSCWEYQGEDKDPVMLKEDLNY
                     QFVVPQTRNYKK"
     CDS             complement(7448..8122)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg474_10"
                     /sec_met_domain="SucD_FumR (E-value: 1.1e-67, bitscore:
                     217.4, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWLLNSSIGKKLIMSISGLFLILFLVFHLCMNIAAVFSGEAYNVI
                     CGLLGSNWYALLGTLVLAAGVVVHFVYAIILTLQNRKARGNDRYAINARPKGVEWASQN
                     MFVLGVIVILFMVLHFTQFWYNMMFAELAGIHGDIHPQDGAAFINFYFQGNVVNTVLYL
                     IWFVALWFHLTHGFWSAIHTIGWNNTVWLSRWECISKWVATIICGLFAVITVIFYLNGV
                     GA"
     CDS             8382..9335
                     /locus_tag="ctg474_11"
                     /transl_table=11
                     /translation="MKTAIFSIGVFLISLFLGSCQPSETSCSVVDTGKTLDYKIGDKLL
                     FSYNYTTVYPAPGVDSVYKRSGFIHPLKTLGGEVMTNCSPADHYHHFGLWYAWTKTTFE
                     GNEIDFWNLHKKQGTVRFRNFEHVSDNGFVATLDHVVYPDSPAEKVAMNERLEINIGTT
                     SLPGYYIDYHTTIRLASPSPITMEAYRYGGICIRTREDWNDQTAEMLTSEGLSRDEADG
                     SRARWCYYQGKAGNEKACILIVASPSNLNYPEPLRVWDKTVNKPAGDVMWNFSPTKQKA
                     FTLEPGKELSLSYRIYVLDKNINATTAEVLSDFERD"
     CDS             10392..13673
                     /locus_tag="ctg474_12"
                     /transl_table=11
                     /translation="MLKKTKLVSLMLLAGTLAVPESAFAEITPERPSVSLSQQNGKVVC
                     VVEDSFGPVIGASVVVKGTTNGNVTDMDGKVVLENLKKGDIIQISYIGYATQEITYTGQ
                     PSIPVTLKEDTQALQEVVVVGYGTQKKENLTGAVAAVAGDVLENRPITNVGQGLQGVVP
                     NLNVTMSKGGAPGSSSDFNIRGNNSINGGSPLVLVDNVQMDANLVNPEDIASISVLKDA
                     ASAAIYGARAAYGVILITTKKGKSEQKPQISVSASGYWQSPALRMHNINSLEYLEMRDI
                     AAANSGMSSLITPGQLDYVKKYMDGSYKYSEYFDQSQDQSRWIYCGNTDWFNELYKTSF
                     SQQYNVNISGGDSKTTYYGSVGFADQNGILKTADDNYKKFNATLNLSSQLTKWLQVSAK
                     IADNYSTEDHPITNSTAGIDAYGGMLKNDLSPLMPVRFGHTGRLVYSPGAAAINDSNLG
                     IQTSGDYIYKEEGINNYSGQNGNTNPAAVGDLGGYTKYKINDLWLTGAVKITPLEGLVI
                     NADYTYNIYSKNASEVQRTFTDYTAVAGTEALYGWTKPSYANYTTNEDYYYAFNAFAEY
                     SKSFLENTHNFKIMAGYNQEKKSNKKYNAKRTNLIVEDIPDLDLATGEQSMSSEDTYWA
                     INGFFFRFNYNYKQRYLLEVNGRYDGSSKFAKDHRYAFFPSVSAAWRISEENFWQPLKG
                     WWNDMKIRGSYGSLGNQVMDDLGNFPYLATYGTNSSYNYLINGSKPVIVKAPGLVAPDF
                     TWETVTQMDFGFDASFLNNRLTGTFDWYRRNTKDMLVAGATLPATLGASVPKSNSADMK
                     TIGWELSLGWNDRLENGFSYWVKGVLSDYQATITKYAGNDAGFYSQSDGDGKYYVGQKI
                     GEIWGYHSNGLFQSDDEAATIDQSELYAGKWGAGDVKYEDLDNDGKITKGEETIYNPGD
                     KSIIGNKTPRYQFGITVGFDYKNFDFEMFWQGTGKRDYMLSGAQFWGFTSQWDVPYTPA
                     LDYWTETNTDAYFPRPGWQNGGNRVTSDRYLQSAAYGRLKNLTVGYTIPKNLTTKWGIS
                     RLRLYVTGENLLTITPLNDAFDPETLGGMTYPINRKVAIGLNLTL"
     CDS             13684..15543
                     /locus_tag="ctg474_13"
                     /transl_table=11
                     /translation="MTMKTKHILLGLSLGLLGGFTACDVTDLNPKDSITDNSYWNTVSD
                     LENYAKGFYMNLTGKGLRADGSENLDDLNTLDERSDNRLVASPDQWLFNEWVIPSEANF
                     DSKWYWNNIRNLNYFMTRYQRVNATESEVNPVVAVIRFFRAFDYFDKIKTFGDVPWYEK
                     DLTTADIDELYKARDDRDFVLGKIIEDLEFAIEWLPEKSAAEVGALHKDAARTFLARVC
                     LHYGTYKKYHNVSTSPTSQELLQKAATLAKEVMDSGLYDIVQGSDAGANQSAFADYPLY
                     YANQFTQEDLTTNKECILARVFEADVLTHNLARGGGVGLSKDFAESFLCKDGLPIANSS
                     EYKGDETLDDEMANRDPRMYQIIDSKYRPYTVKSNGMRVVNSGIDDKKEFSPSEEPGTN
                     IHSAPGLTGTATGYSPIKLVSASQSQQDAVKTSSYDWFVFRYAEILLIYAEAKCELGEC
                     TQAVLDETINKLRDRVEMKHLTVSPVADLNPVDYGYSITPLLYEIRRERRIELALEGFR
                     YDDIMRWNAMKLFENPKTYLGMRVTDKVKALYQPEVFEGSTARDLIEYNGKTYIRMYSG
                     KSLNEAGRKWTGNDKRLYYPIPTSQITLSASHGSLLKQNPGWE"
     CDS             15744..17021
                     /locus_tag="ctg474_14"
                     /transl_table=11
                     /translation="MNKKDLILNILLFISQIIVFYYFFCYLFPFKEQLQMFQFTSQYLT
                     ETLKQAGGVAIYISEFLSQFYVVFWTGPIISALLLTLVALLSSLILKKINSRNDLPLIF
                     LLPWLSLLIISLDYDYYEQGTIAYLFLLLFLWLYTNIKTRIKFIYGICIIPILYGIAGP
                     IVHLFAISALFFEFLTNGKKKYISIIYLLIAALSAIAGTYLGYSRNLTLAFLPEAYCNP
                     LQTVSGIYYAWYALPMTMLLVAYLKRYKEPVSLKGKCIWEGAQWAIMFLLVYQGIFHFG
                     KLDAQHSMKQDYLLRTEQWDLVISEFNHDVLSKRRMCGLNLALAHKGQLSERLLDYPQH
                     GIETLMLHWDQSIYTAQLHSDLYYCMGIISAAQKFAFEAFVSSRSSGNPRMLKRLIETN
                     LITGSYPIADKYIQLLEKTWFYKDWAT"
ORIGIN
        1 aaagaaatct gtttcggaca gggaaacgac atttcttttc tgccggtagc gggaatatcc
       61 ccagattccg gtactgcaag agacaagtag cgtgacccag acatatattt gttctttttg
      121 tgccttttgg ctatcggtta aacgtttttc ccattctttc tgttccgagg tacgaaggag
      181 ttgggtaatt tgattttgtt ctttttcctg tcgcaggacg gataagtgat ggaggtagct
      241 tttgtggtag aaatcagctt gcaggctgtc tccacggctt tgggcgatgc gggacagggc
      301 agcatacaga tgcgggtggg aaggggggac ctgacttaaa ctcttttcgg cttcgtccaa
      361 ttttcccaaa gtaatctgca aatcagccaa agccagacat acttctgctt tctctttcgg
      421 gaaaatcgtt tgttccaact ccgtttttaa taaagtttca gcctctttat tgcttccatt
      481 ctgttgcaat atctttgcct gttttatccg acatccagcc atttcataat agtgaaaggc
      541 actgtctgct tgtccggaca aggtatacat atcccctatt tcccggtaaa gttccagccg
      601 tagcgaatcg caggcaggac ttttgatata gcttaatgct tttttctcac tttgtagtgc
      661 cttttgtttt aaagattgat accgatagat ttttcccatt tccaggtagg caagggaaaa
      721 gacggtgctg tctttctcct tctccgccaa tttgattgcc tgttgatagg tttccaatgc
      781 cggaagaaat tgcaatcttt ccccatagaa agcagcctgt cgaaggagct ctccggcggt
      841 gacaatctct ttttgttcgg tagaagaaca ggcggtgaaa aagcaaatga aaaagagtat
      901 ctttacattg tgtatcatct gaatccttct tttgaaggag taaagataat aatattcctc
      961 tccgtttacc ccctggagca ggttttgtaa acggagagga tgataaatag ataatccgtg
     1021 tttctgattt taatcgacga attgcaggat ctcgtattgg acagggtaat tgattttctt
     1081 tttcagttct tgcttaaccg tttccaacag gtctttggga gtacttttgt taatctttat
     1141 acttactttc gtaatattgt ccttgtaaat cttgtctatg cgttgtccga gattggctcc
     1201 cggtttggca tggcgatcgt ataaaacgaa ctgttggtcc ggctgcccgt cccggtaact
     1261 gaaaataacc tgtccggcag gaggtggggg aggtggagcc gcagcatctc cgatcttgaa
     1321 aatattcatg ttgatttcgc ttgtcaatcc ttttttgtcc aacaagtttt ttaatttctc
     1381 catttcttgt ctggatactt tcggattttc aggttggaga attaaggaag ctgatttgga
     1441 tatcttatcc agcctcggat cattctggtt tgcactaaac ttactgatgc ttagtgctgc
     1501 gacaatcttt ttattctgaa tcagataaac cacatcgtca tatttgcggt aaggtttggc
     1561 aacatcatcc atgatagtat tcggaacagt catgtcgatc ttgcatttaa tatctctttc
     1621 ttccaaaaca tcttttactg tttccagata agaagccggg atatcgtcga aggccggatt
     1681 aacagtaact tccagggcgt tcttgaattg tccctccgct actcgtgttc tgattctgtc
     1741 cagagttttg catacaatac tgttcagatc ctccgaaccc gattctttgt aggtgaggaa
     1801 aactgcatga tcctgttgca tcgtttcctg atttaccgta cttttgttaa tcgatagatg
     1861 aatgttgtcg gtcattgtcg ctgccggcgg cggacttgtt tccggacggg cgaatgcact
     1921 taaggccgcg aagcctaccg ggaccaggag cgcaagcttc aaccgggccc aattgtttga
     1981 tttctttttt aacatcatag taatacgttt tttaatttta ctgtgattga agctgttggc
     2041 aagagtgtag aggctggagc cgacagcttt tttcacgagt aatagttgat attttgttgc
     2101 atcgatgcct tgactgagta cgcctttatc cgcctggtat tcgtgtatgc cccgtaattc
     2161 cctttttaat aaccatacgg caggattaaa ccattgcaga agaagaatcg tttcatatag
     2221 atcagatcga ccgaatggtt atagcggagg tgcatttttt cgtgcatgag gatttcgttc
     2281 ggatggttcc ggtaatcgtt ttccgaaagg aatatataac gtccccaact gaaaggggat
     2341 acgggatcgg gagtcaggat taacgtgtat ttcccctgtt ttagtttcct gttttttctt
     2401 gttagttgat acatttttcc gaatgacaga atcgttgtgg tcaggcagat accactgcct
     2461 gttagaaaag caatcccgat aattcccgtc cagggaacag atatatttct ctgctctgtc
     2521 ggaatcgtaa tttcttcttt gctttccgga acaggaaacg ctttcatctc ttcttcatag
     2581 aaaactatct ccagttggct gactggccgg ctaagaggaa aaggccgggc tgtttggatc
     2641 cggcaaagtg gcagcaacat gcaaactcct gtccctacca gtaatatcca gcggttgaac
     2701 cggaaaaacg tgtcgttact gaataatgcc ttgaaacaga cataaaagac tgtcaggcaa
     2761 ataccagatt ttaatatgta tagaagaaaa gcgtccataa gcgttggttt tttatttgtt
     2821 ttttatctgc tggatcagct tctgtaactc gtcgatcgtg agcacctctt cttctatcag
     2881 cgtcgaaacg acacgggtgt acgagttgtc ataatatttg ctgatcacct gtttcaagga
     2941 attacgccgg tattcgtctt ccgataccag tgcatagtat tggtgcgtat taccgtatac
     3001 cttgtatccg atatatcctt tttcttccaa tgagcggaca atcgtggaca aggtgttata
     3061 atgcggctta gattcttcct gtaagtcgag tagttcgcga acgaacaggg ggcctttcgc
     3121 ccaaaagtag cccaatattt cttcttcttt tgatgttaat ctaaccataa tccgtttttt
     3181 gttagaggaa tgcacaaata caactatatt atttagtaac acaactatat catatagtta
     3241 ttttactata ttttttagta gatatccttt tatccctgtt tttagcagga aatcagtacc
     3301 tttgtccccg tcattgataa tataaatatg aaaataggta caatagattt aggcgaacgc
     3361 cccgtcttct tagctccgat ggaagacgtt acagatattt ctttccggtt gatgtgcaaa
     3421 cgttttggtg ccgatatggt ttataccgaa ttcgtttcag cagacgccct aatccgcagt
     3481 gtaaataaaa cacagcaaaa gctgaatgtg gcggatgaag aacgtccggt cgccatacaa
     3541 atatatggcc gtgatgttcc gacaatggtc gaagccgcgc aaatttgcga agccgctcat
     3601 ccggacattc tcgatatcaa tttcggttgc cctgtcaaac gagtggcagg caaaggagca
     3661 ggcgccggca tgctgcgcaa tattccactg atgctggaca tcacccgtga agtcgtcaaa
     3721 gcggtgaaca tccctgtcac cgtaaaaacc cgcttgggct gggatgccga caaccggatc
     3781 atcgtagact tggccgaaca gctacaggat tgcggtatcg cagccctttc catccacgga
     3841 cgtacccggg cacagatgta cacaggagag gcagactgga cactgatcgg tgaagtaaaa
     3901 aacaatcccc gtatacaaat tcccatcatc ggcaatggcg atgtgacttc cgccgaaatc
     3961 tgcaaacaac gtttcgaaca atatggcgtg gatgccgtta tgattggccg gggcagcata
     4021 ggccgcccct ggattttcag agaagtgagg cattatctgg atacaggcga gacattgcct
     4081 gccgaatctt tttcatggta tctggacata ctgaaaaagc aggtggaaca aagcgtggaa
     4141 cgtttggatg agcgccgggg aattctccac attcgccgcc atttggctgc aactccgctg
     4201 tttaaaggta ttgcagactt caagcagaca cgcgtcgcca tgctacgtgc ggaaacagtg
     4261 gaagcattat tcgacattct ggattccatc cccgacaaat ttcatacagg atacggattt
     4321 caaagcgact ctcaagtgtc agaatcgatc gattgttgat ataataacag tgtgaatccg
     4381 cacacagtgt caattttaaa acaaaaagta gcaaatttgc aataaaatgt aattacaaac
     4441 tcttgcgtat tcagtaaata tactttatat ttgcagtgag tttttttcat agtattttag
     4501 atctaaggtt aacaaagtct ttgcagagag ggaatcgaga gactgtttca ctggaaagca
     4561 acaaaaaagc cgcatccact tttattatag ggagtgcggc ttttttgtgg gtttgaacga
     4621 acataaagaa agcccgttgc cattggcgac gggcttttcc atatacatac atatataatg
     4681 tattagtctt gtaacttagc agagatgaac tcgcggttca agcgagcgat gttgctaacg
     4741 gagatgttct tcggacattc catttcgcaa gcgcgagtgt tcgtacagtt accaaagccc
     4801 agttcatcca tcttagcaac cattgctttt gcacgacgag cagcttccac cttaccctga
     4861 ggcaaaagag ccagctggct aacctttgca gagacgaaca gcatagctga accgttctta
     4921 caagcagcag cacaagcacc gcagccgata caagcagcag catccatagc caaatccgca
     4981 tcagccttag aaataggaat tgcattagca tcaggaaccc cacctgtgtt tacagaaacg
     5041 aaaccacctg cctggataat cttatcataa gcataacggt ctaccatcaa gtcgcggatt
     5101 accgggaaac cagcagaacg ccacggctcg atcgtaatcg tctcaccatc attgaaacgg
     5161 cgcatataga gctgacaggt tgttgcacct gttgccggtc cgtgcggatg tccgtttaca
     5221 tacaatgaac acataccgca gataccttca cggcagtcgt ggtcgaatac gataggttct
     5281 ttgccttcgc taaccaaacg ttcattcaaa atgtctaaca tttccaagaa agaaacactc
     5341 tgattgattt tgtcgatttg gtaagtctca aactgtcctt tatctttcgg acctttctga
     5401 cgccaaactt taagtgttac ctttatatct ttatccatga ttctaatttt tgtgattgat
     5461 gattattact tcttgtagtt acgtgtttga ggaacaacga actgatagtt caaatcttcc
     5521 ttcagcataa ccgggtcttt gtcttcaccc tggtattccc aacaagagac gtacatgaac
     5581 ttatcgtcat gacgcatagc ttcgccttct tcggtctgat gttccgtacg gaagtgacca
     5641 ccacaagatt ctgcacggtc taacgcatcg tgtgccatca acgcaccgat ttcgataaag
     5701 tcagccaaac gcaatgcctt gtccaattcc acgttcaagc tattggcctc acccggaatg
     5761 aatacattgc tccagaattc cttcttcagg tctttcaaca tttggatagc ttctttcaag
     5821 ccttccgcgt cgcgtgccat accgacgtgt tcccacatga tatgtcccag cttacggtgg
     5881 atagaatcga ctgtttcttt acccttcacg ttcatcaact tcgcgatacg ggcgttaata
     5941 gccttttctg cttccacaaa ttcaggcagg tcagtgctaa agcgcggaac ctggatctgg
     6001 tcagacagat agttctggat cgtgtaaggc aatacgaagt aaccatcggc caatccctgc
     6061 atcaaagcag aagcacccag acggttagcg ccgtggtcag agaagttggc ttcaccaatt
     6121 gcgaacagcc ccggaataga agtcatcaat tcatagtcta cccacaaacc acccattgag
     6181 tagtgcaatg caggataaat catcatcgga gtttcgtacg gatcatcgtt cgtgatctct
     6241 tcgtacatat cgaacaggtt accatatttc tgtttaacca cttccttacc cagacggttg
     6301 atagcatcgg agaaatccag gaatacagcc aagcccgtgc tatttacacc gaaaccggca
     6361 tcacaacgtt ctttagcggc acgtgaagcc acgtcacgag gaaccaagtt accgaatgcc
     6421 ggataacgac gttccagata gtagtcgcga tctgcttcag gaatatcctt tccctttttt
     6481 gttccggcct gcaatgcctt cgcatcttcc agcttcttcg gaacccagat acggccgtcg
     6541 ttacgcagtg attctgacat caaagtcagc ttagactgga agtcaccttt caccggcaca
     6601 caagtcgggt ggatctgcac catacaagga ttagcaaagt aagccccttt cttgtagcac
     6661 tgccatgcag cagaaccgtt agacgccatc gcgttagtag acaagaagaa tgtatttaca
     6721 taaccacctg tcgcaacaac gactgcgtga gcggcaaaac gttcgatctt accggtaatc
     6781 aaattacggg caataatacc gcgagcacgt ccgtcaacct tcacaacatc cagcatttca
     6841 tggcgtgtgt acatcttcac ctttcccaaa ccaatctgac gactcaatgc agagtaagca
     6901 cccaacagca gctgctgtcc ggtctgacca cgagcataga acgtacggga tacctgagca
     6961 cccccgaatg agcggttatc caacagacca ccatattcgc gagcgaatgg tacaccctgt
     7021 gctacgcact ggtcgataat agagtttgac acttcagcca aacgatagac gtttgcttcg
     7081 cgggcacggt agtcaccacc tttgattgta tcgtagaaca gacgataaac cgagtcacca
     7141 tcattctgat aattctttgc cgcattgata ccgccctgtg cagcgataga gtgtgcacga
     7201 cggggagagt cctgaataca gaaattcaat acattgaatc ccatttcagc cagagaggca
     7261 gcagcagaag cacccgccag accagtacct actacaatta tgtccaaacg acgtttgttt
     7321 gcgggattca ccaatttctg gtgattttta taatttgtcc acttctcagc caacgggcct
     7381 tgaggaattt tagaatctat ttgagtcata atgttttatt ttcaaattga aaaaataata
     7441 tccgaaatta agcacctaca ccgttcaggt agaagataac tgtgataaca gcgaataagc
     7501 cacaaataat agtggcaacc catttagaga tacattccca acggcttaac caaacggtat
     7561 tgttccagcc aattgtgtga atcgcagacc agaaaccgtg agtcaggtga aaccacagag
     7621 caacgaacca aatcagatac aacaccgtat tcacaacatt gccctggaag tagaaattga
     7681 taaacgctgc accatcctgc ggatgaatgt caccatgaat acctgccagt tcggcaaaca
     7741 tcatgttgta ccagaactga gtaaagtgca gaaccatgaa caggataacg atcacaccca
     7801 aaacaaacat gttctgagaa gcccattcaa cacctttcgg acgagcgttg atggcataac
     7861 ggtcgttacc gcgagcctta cgattctgca gagtcaagat aatagcatac acgaagtgca
     7921 cgactacacc tgcagccaac accaatgtac cgagcaaagc ataccagtta gaacccagca
     7981 aaccgcaaat cacgttatac gcttcaccag aaaatactgc cgcaatgttc atacataagt
     8041 ggaacaccaa gaacagaatg agaaaaagac ctgatatact cattatcagc ttcttcccga
     8101 tagaagaatt aagtaaccac ataagataat aatttaagtt atttaattgt atttagaaat
     8161 ttcctccaat ctatggttat tatcgtgcaa aggtatgcta aatccccata tcacgcaaac
     8221 gattaaagaa atatttcatc aattagaacg ctgcttgctg gctggtttta tttgcatcag
     8281 atatcacaaa cggattgtgc gaaacgaaaa aatttcgttt ttttgtagcc gatacaggca
     8341 aggtcttgcc ggataactga ttattattta attgtcatat tatgaaaact gctatttttt
     8401 ctattggtgt ttttttgatt tctctgttct taggctcttg tcagccttcc gaaacatcct
     8461 gttccgtcgt cgacacgggg aaaaccttag actataagat aggagataaa ctgttgttct
     8521 cttacaacta taccacggtt tacccagccc ctggcgttga ctcggtctat aaacgcagcg
     8581 gtttcatcca tcctttgaag acattgggag gcgaagtgat gaccaattgt tctcccgccg
     8641 accattacca tcatttcggt ttgtggtatg cctggacgaa aaccacgttc gaaggaaacg
     8701 agatcgattt ctggaatctc cacaaaaaac aaggaacagt tcgcttccgc aacttcgaac
     8761 acgtatccga caacggtttt gttgcgacac tggaccatgt ggtctacccc gattctcccg
     8821 cagaaaaagt agcaatgaac gaacgcctgg agatcaacat cgggacaaca tccttaccag
     8881 gttattacat cgactatcat accactatcc gcctcgccag ccccagcccg atcaccatgg
     8941 aagcttaccg ttatggcggc atatgcatcc gtacgcgcga agactggaac gatcagacag
     9001 ccgaaatgct cacctcggaa ggcctttccc gcgacgaagc tgacggttcg agagcccgtt
     9061 ggtgctacta ccaagggaaa gccggaaacg aaaaggcctg tatcctaatc gttgcctccc
     9121 cttccaacct aaactatcct gagcccttac gcgtatggga caaaactgtc aacaagcctg
     9181 ccggtgacgt catgtggaat ttctcaccga ccaagcagaa ggcattcaca ttggaacccg
     9241 gtaaagaact gagcctgtct taccgcattt atgtattgga caagaacatc aacgctacta
     9301 cggcagaagt gctgtccgat ttcgaacgtg attgaatttc tactaaaaca aactgacaat
     9361 ttgcagggca aggtaaacaa gaaaaggaaa aagggcttgt tctcctatat catcaaagac
     9421 aaggctcttt tatgtaaata cagctacaaa tcaatgaaaa acacgtaata aaacttaccc
     9481 aacaccccca tgtatccgcc cccgacaccc ggatctataa gagcgtaaga tccgggtgtc
     9541 gggggcggat acatgggggt gttgataaaa ttgtctccct acttttacct taaaatgctt
     9601 ggagtttatt catttaaaac agatagatga gcgattacag atagtgatag aagcgtgata
     9661 tataaaacag gtatctatca cttcagatac gcactgatta tcaagactca cacgacattt
     9721 agtgatagag tgacagatgt tcatgaaaaa acatcctaga aatcacccca tcccgactac
     9781 tgagcttcaa taaagttgca ctaaaattag ataaattaac acaggcattg tatttcattg
     9841 cctattgccc ttttcccagt ttttcgacag atacaaaatc atgttctgtg ctgatgagaa
     9901 tatgcataac cacaaaactt tcagacaaat atgcaatatt ataaaaataa gattattttt
     9961 tgaccaccca tgcacagaaa gagatataag ttctatcaga actatggttt ttaattatct
    10021 catatccggg tcaaaggtat gaaattttca tttcgttgta tgttttttta ttaaaaaagt
    10081 tcatatagca ctcattttta acaattcaga cttacaggct accaacaagc atcagacaat
    10141 atcagacttt tgaacctttt taagcacaag aagtaatttg cggcttatca ttcaactcta
    10201 tttttgtaca atattcacac ttatcagata catttcttca taaatacatg agttctgata
    10261 gaactaaatt acaaaaacac agaaaaacgc tataaaaata tgcaaaatct aatgagcatg
    10321 atctaataaa gacactcaac agatgtaagc cgttttcgtg gtatgtatta tttcttttaa
    10381 atatatactc tatgttgaaa aaaactaaat tagtaagtct gatgctactg gcaggaactt
    10441 tagctgttcc agaaagtgct tttgccgaaa ttactccgga aaggccgtca gtaagtctat
    10501 cccaacaaaa tgggaaagta gtatgtgtgg tggaagattc gttcggccct gtgatcggag
    10561 cttcagttgt tgtaaaagga acaaccaacg gaaatgtgac agacatggac ggcaaagttg
    10621 ttttggaaaa tttgaagaaa ggagatatta ttcaaatttc ttacattgga tacgcgacac
    10681 aggaaataac ctatacagga caaccgtcaa tccctgtaac attaaaagaa gatacccagg
    10741 cgctacaaga agtagtagta gtaggttacg gtacacagaa aaaagagaat ttgacaggtg
    10801 ctgtggcagc tgttgccggt gatgtactag aaaaccgtcc tataacaaat gttggacaag
    10861 gattacaagg tgttgttcca aacttaaacg tcaccatgag taaaggtggt gctcctggta
    10921 gtagctctga ctttaatatt cgcggtaaca actcgattaa cggtggtagc cctttagtgt
    10981 tagttgataa tgttcaaatg gatgccaacc ttgttaatcc ggaggacatc gcgtctattt
    11041 ctgttttaaa ggatgccgca tctgctgcta tctacggtgc ccgcgctgct tatggcgtta
    11101 ttttaattac aacaaagaaa ggtaaaagtg aacaaaaacc tcagatttcc gtatcagcaa
    11161 gtggctattg gcagagccct gcattaagga tgcacaatat caactctttg gagtatctgg
    11221 aaatgagaga tattgctgcc gccaatagcg ggatgagctc cttgatcact ccgggacaat
    11281 tagactatgt aaagaaatat atggatggct cttataagta ttcagaatat ttcgatcagt
    11341 cgcaagatca aagtcgatgg atttattgtg gcaacactga ttggtttaat gaattgtaca
    11401 aaacaagttt ctctcaacaa tataatgtaa acattagtgg tggagactca aaaacaactt
    11461 attacggctc tgtcggattt gctgaccaga atggtatttt aaaaacagct gatgataatt
    11521 acaagaaatt taatgcgaca ctgaatcttt cttcacaact gacaaagtgg ttgcaggtca
    11581 gtgccaaaat cgcagataat tattcaacag aggatcaccc cattaccaac tctacagctg
    11641 gaatcgatgc ctatggaggt atgttgaaaa atgacttaag cccgttaatg cctgtacgtt
    11701 ttggccatac aggaagactc gtttatagtc ctggcgcagc agccatcaat gattctaact
    11761 taggtatcca aacttcaggc gattatatct ataaagaaga aggtattaac aactattcag
    11821 gtcagaacgg gaacacaaat cccgctgctg taggagattt aggcggatat accaaatata
    11881 aaatcaacga tttatggttg acaggtgctg taaaaatcac tcctttggaa ggattggtta
    11941 tcaatgctga ttatacatat aatatttata gcaagaatgc atcagaggtt caacggacat
    12001 ttacagatta tacggctgta gctggaacag aagctcttta tggttggaca aagccaagtt
    12061 atgcaaatta tactacaaat gaagattact actatgcatt caatgcattt gcagaatatt
    12121 ctaaatcatt tttagaaaat acgcataact ttaagattat ggccggttat aaccaagaaa
    12181 agaaatccaa caaaaaatat aatgcaaaac gtaccaatct gattgttgaa gatattcctg
    12241 acttggattt ggcgacaggt gaacaaagca tgtcttcaga agatacatat tgggcaatta
    12301 atggtttctt cttccgcttc aattacaatt acaaacaacg ttatctactc gaagttaacg
    12361 gccgttatga cggttcatcc aagtttgcaa aagatcatcg ttatgcattc ttcccatctg
    12421 tttccgcagc atggcgtatc tcagaagaaa atttctggca gccgttaaaa ggttggtgga
    12481 atgatatgaa aatccgtggt tcttatggtt cattgggaaa tcaggtaatg gatgatctag
    12541 gtaatttccc atatttagca acatatggga cgaattcttc ctacaattat ttgattaacg
    12601 gatccaaacc tgttattgta aaagcaccgg ggcttgtcgc tcctgatttt acttgggaaa
    12661 cagtcactca aatggacttc ggttttgatg cttcatttct gaataatcga ctgacgggaa
    12721 catttgactg gtatcgtaga aatacaaaag acatgttggt agccggagca actttacctg
    12781 caacattggg cgccagtgtt cctaaaagta actctgctga catgaagacc ataggctggg
    12841 aactttcttt aggatggaat gatcgattag aaaatggatt ttcttattgg gtaaaaggtg
    12901 ttttatctga ctatcaggca actatcacca aatatgccgg aaatgacgca ggtttctatt
    12961 cacaaagtga tggtgatggt aaatattatg taggacaaaa gattggtgag atttggggat
    13021 atcactcaaa cggccttttc caatcagacg atgaagctgc aacaatagac caaagcgaac
    13081 tttatgctgg aaaatggggt gcgggtgatg taaaatacga agacttagat aatgatggta
    13141 aaatcacaaa aggggaagaa acaatctata acccgggtga taagagcatc ataggtaata
    13201 aaacacctcg ttatcaattt ggtattaccg ttggatttga ttataagaac ttcgatttcg
    13261 agatgttttg gcaaggaaca ggaaaacgtg actatatgtt gagtggcgct cagttctggg
    13321 gattcaccag ccaatgggat gttccatata ctccggccct tgattattgg acagaaacaa
    13381 atacagatgc ttattttcca agaccaggat ggcaaaatgg cggtaacaga gtcacaagtg
    13441 accgttattt acaaagtgca gcttacgggc gtttgaagaa tttgacggta ggttacacaa
    13501 ttccgaagaa tctaacgaca aagtggggca tttctcgttt gagattatat gtgacaggag
    13561 aaaacctact cactatcact cctctgaacg atgccttcga tcccgaaaca ttgggaggaa
    13621 tgacataccc gattaatcga aaagttgcaa ttggattaaa tttaacactg taaaaaacga
    13681 aagatgacaa tgaaaactaa acatatctta ttaggattaa gtcttggatt gttaggagga
    13741 tttacggctt gtgacgtgac agacctcaat ccaaaagaca gcattaccga caatagctac
    13801 tggaatacag ttagcgattt ggaaaattat gccaaaggct tttacatgaa cctgacagga
    13861 aaaggtttaa gggcagatgg aagtgaaaat ttggatgatt taaatactct tgatgaaaga
    13921 agtgacaatc gtctggtcgc ttctcccgac caatggttgt tcaacgaatg ggttatacct
    13981 tctgaagcaa atttcgattc aaaatggtat tggaacaata ttcgtaatct aaactatttt
    14041 atgactcgtt accaacgggt aaatgcgaca gaatctgaag taaatccggt tgttgccgta
    14101 attcgctttt tccgggcttt cgattatttc gataaaatca agacatttgg agatgttcct
    14161 tggtatgaaa aggatttgac aactgccgat attgacgaat tgtataaagc acgtgacgac
    14221 cgtgactttg tactagggaa aattatcgaa gatctggaat ttgcaattga atggttaccg
    14281 gaaaaaagtg cagcagaggt aggtgcttta cataaagatg ccgctcgtac atttttagcc
    14341 cgtgtttgcc tacattatgg aacatataaa aagtatcata atgtttcgac atcacctaca
    14401 tctcaggaat tattacaaaa agcggcgact cttgccaaag aagtgatgga tagtggtctt
    14461 tacgatatcg tacaaggctc ggatgccgga gcaaaccagt ctgcttttgc cgattatccc
    14521 ttgtattatg caaaccagtt tacacaagag gatttaacga ctaataaaga atgtatttta
    14581 gcacgtgttt tcgaagcaga cgtattgact cataatctcg ctcgtggtgg aggagtcggc
    14641 ctttctaaag attttgcaga atcattcctt tgcaaggacg gtttgcctat tgcaaacagt
    14701 agtgaataca agggagatga aacactggat gatgaaatgg caaaccgcga tcctcgtatg
    14761 tatcagatta tagacagtaa atatcgtcca tatacggtca aaagcaatgg tatgcgtgta
    14821 gtaaattccg gtattgatga taaaaaggaa tttagtccgt ctgaagaacc aggaacaaat
    14881 atccattcag ctccgggatt aaccgggact gccacaggat actcacctat caaactggtg
    14941 tcagcaagcc agagccaaca agatgcagtg aaaacatctt cttacgactg gtttgttttc
    15001 cgttacgcag aaatcctgct gatctacgct gaagccaaat gcgaattagg tgaatgcaca
    15061 caggctgttt tggatgagac gattaataaa ttgcgcgacc gtgttgagat gaaacattta
    15121 acagtatctc cagtagccga tctgaatccg gttgattatg ggtattctat aactccgttg
    15181 ttatatgaaa tccgccgtga acgtcgtatt gagttggctt tggaaggttt ccgttatgat
    15241 gatatcatgc gttggaatgc gatgaaacta ttcgaaaatc ctaaaacata tctaggcatg
    15301 cgtgttacag ataaagtaaa agcgttatac caacctgaag tatttgaagg atcaacagcc
    15361 cgtgatttaa tcgaatataa tggtaaaact tatatccgca tgtattctgg taaaagtttg
    15421 aacgaagccg gccgtaaatg gacaggaaac gacaagcgtc tgtactatcc tatcccaaca
    15481 agtcagatta cattgtctgc aagccatggt tctcttctaa aacaaaatcc gggttgggaa
    15541 taaatctcat acaagaggga aggttagcct tccctcttta tttccctcaa taaaatataa
    15601 tgagaatata ttacttatct tattgtctgc tggctaacag gacgtttata ttacaatctt
    15661 atagaatata tagagagtta cacacatcat aaatgttccg aaatcaggca tgtatacagt
    15721 aggtgttcaa aacgggattt tatatgaaca agaaagactt aatattaaat attcttttat
    15781 ttattagtca aataatagtc ttttattatt tcttctgcta tttattccct tttaaggaac
    15841 agctacaaat gtttcaattt acatcacagt acctaactga aacactgaag caggctggtg
    15901 gtgtcgctat ttatatatcg gaatttctct ctcaattcta tgtggtattt tggacaggac
    15961 ctatcatttc tgctctactt ttaactttag tggctttatt atcatcatta atactgaaaa
    16021 agattaactc acgaaacgat ttacctctta ttttcctgtt accctggcta tctttactaa
    16081 ttattagttt agactatgat tattatgaac aaggaactat tgcttattta tttttattgc
    16141 tttttctatg gctatataca aacataaaaa cacgaataaa atttatttat ggcatttgca
    16201 tcattcctat tttatatgga atagcaggtc ctatcgtaca tttatttgct atatcggcat
    16261 tgttctttga gtttttaacc aatggaaaga aaaaatatat tagtattatt tatttgttga
    16321 ttgccgcact ttcagcaatt gcaggtactt acttaggata tagtagaaat ttaactttag
    16381 cgtttttacc agaggcttat tgtaatccac tacaaacagt atccgggata tattatgcat
    16441 ggtatgcatt acctatgaca atgcttctgg ttgcttattt gaaacgatac aaagaacccg
    16501 tttctctaaa agggaaatgt atatgggaag gggcacaatg ggcaatcatg tttctattgg
    16561 tctatcaagg aatctttcat tttgggaaat tggatgcaca gcattccatg aagcaggact
    16621 atttgctccg gacggaacag tgggaccttg ttatcagtga atttaaccat gatgtattgt
    16681 ctaaacgccg aatgtgcggt ttaaacttag ctttggcaca taaaggccag ctttcagaga
    16741 gattgttaga ttatcctcaa cacggtattg aaaccttgat gctacattgg gatcagtcga
    16801 tctatacagc acaactgcat agtgatctgt attattgtat gggaataata agcgcagcac
    16861 aaaaattcgc ttttgaagcg tttgtcagtt ctcgttcttc cggtaatccg cggatgttga
    16921 aaaggctgat agagacaaat ctgataacag ggtcctatcc gattgcggat aaatatattc
    16981 aattgttgga aaagacttgg ttctataagg attgggctac tgc
//
