LOCUS       c00305_gnlPro..        14436 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LGPHAHFH_305.
ACCESSION   c00305_gnlPro..
VERSION     c00305_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 07:38:44
            Original ID  :: gnl|Prokka|LGPHAHFH_305
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14436
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..258
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg305_1"
                     /sec_met_domain="ILVD_EDD (E-value: 8.2e-27, bitscore:
                     85.1, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="GGTSGLSIGHVSPEAAAGGNIGKIVDGDIIEIDIPARTINVRLTD
                     EELAARPMTPVTRDRYVPKSLKAYASMVSSADKGAVRLID"
     protocluster    1..14436
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:4436]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..4436
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14436
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14436
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(396..1400)
                     /locus_tag="ctg305_2"
                     /transl_table=11
                     /translation="MKFGTNDFFFLYRFIFLETIDPLSVPVLFQQSGHSSQRLFAVAQN
                     GNVYLYILIYFRRINIKMDHFRLFGVSSQITGHTVVETHTDSNQYITFVSIDIRSQISV
                     HTQHSFIQRMVGRQCGKSEQGTTCGHIRLFDKGTQFFLSASQFHSLSYQDKRAFGVVDQ
                     FGGSLYRFFVCIGNRNIAADKLLLCRLVFRFFNLRILGKVEYHRTGTTTTGNVESTCYC
                     PGYVFGTANLIAPFSDWLSDTYEIDFLKSVCSKKACSHLSCNDNDRRTVYHCICNTCDR
                     IGCSRAACHQANTDFTRYTGVALCRMGSSLFMANQDMVQCILMVVQGIERRHD"
     CDS             complement(1413..1658)
                     /locus_tag="ctg305_3"
                     /transl_table=11
                     /translation="LQSAVTHKYAYHAVGTAESSSDSCRKAKTHRAESARSNDTTFLGI
                     FKVAGRDHLILTYICHQYGFVTGRFAYRTHHFAHTQ"
     CDS             1659..2003
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg305_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-23, bitscore:
                     74.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIQELGTIMEQKAPVKIICLNNNYLGNVRQWQAMFFNRRYSFTP
                     MLNPDYMKIASAYDIPSKRVFSREELKAAIDEMLSTDGPFLLEACVVEEGNVLPMTPPG
                     GSVNQMLLEC"
     CDS             complement(2037..2285)
                     /locus_tag="ctg305_5"
                     /transl_table=11
                     /translation="MEINLVFRKIVRLNHINLLFDLLHHLFNSVLISPRCDRIFMYSFN
                     GRSRNVQTLDVYLPTGKYSGHLIQQSGYIFRMNYNRI"
     CDS             complement(2438..3106)
                     /locus_tag="ctg305_6"
                     /transl_table=11
                     /translation="VSVNIDITVFCRQRRNRLIACHLDTRRLFYRAGFIAYIIDDASSM
                     QCQQIGRLTGIQIDHRPYGTGIADLLSFLVNDGKVTVGKQTIDILYPCLNRELLVLVRH
                     LIQLDRQTGKHPCVIVLVQRSNTKSTVAGMKTCAIQQMISQHAHCQAPVKIYVERLCHK
                     LISPYFIFFTHYSCYFLLCLYFASCPSRNSFTRSKQLVVIATRPERTNCNTHFKARSSS
                     "
     CDS             complement(3096..3761)
                     /locus_tag="ctg305_7"
                     /transl_table=11
                     /translation="MREIKSFSCSQVRLDSRPYRHYRCIRQQAHNDRTFFASFFNTEQS
                     FTRNPSVSYRFVICLSLALTNDYIETVITKVQSLSRTLYAITDYSDCFIFQYFTSFFQW
                     KFITDNYIFYSSAKIQLCHFFLFFCFDDLRHLLLIDFILYIIQISLWNGILPRCRFSSP
                     LHETRFHSPHHRRKRVHLRNNFQPHTPFQTGGYVSSDTVLSETSQVCARYNEYCLRVR"
     CDS             3864..4436
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg305_8"
                     /sec_met_domain="IlvC (E-value: 1.2e-40, bitscore: 130.4,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFLEGRGLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIR
                     EATSDLTGERGSLMGAIQGLLLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGM
                     DWMYANCSTTAQRGALDWMGPFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKL
                     EEELKALRESEMWQTAVTVRKLRPENN"
     CDS             complement(4969..6915)
                     /locus_tag="ctg305_9"
                     /transl_table=11
                     /translation="MKYIFVSGRRFITFASIMNNHPKSPIIDLQQQQLLLRMEYEHEKE
                     EFKRQTETMGVARKVKRGLCWYPASPGRSYYNSLNQLVIDITRTENKEIEHSFEFGRPV
                     CFFRQSFDGKVNYMNFIATVSYADDERMVVVLPSAGALLELQTEEVLGVQLYFDETSYR
                     AMFEALEDTIRAKGNRLAELRDTLLGTQKPGFRELYPVRFPWLNSTQETAVNKVLCTRD
                     VAIVHGPPGTGKTTTLVEAIYETLHREPQVLVCAQSNTAVDWICEKLVDRGVPVLRIGN
                     PTRVNDKMLSFTYERRFENHSAYPELWGIRKSIREMGSRMRRGSYSEREGMRSRMSRLR
                     DRATELEILINADLFDSARVIASTLVSSNHRLLNGRRFPTLFIDEAAQALEAACWIAIR
                     KADRVILAGDHCQLPPTIKCIEAARGGLDHTLMEKVVQQKPSAVSLLKVQYRMHEAIMR
                     FPSEWFYNGELEAAPEVRNRGILDFDTPMNWIDTSEMDFHEEFVGESFGRINKQEANLL
                     LQELEAYISRIGKARILDESIDFGLISPYKAQVQYLRSKIRGSSFLRPFRSLITVNTVD
                     GFQGQERDVVFISLVRANEDGQIGFLNDLRRMNVAITRARMKLVILGDATTLTKHAFYR
                     KLIQYIRQEAVSS"
     CDS             6982..9225
                     /locus_tag="ctg305_10"
                     /transl_table=11
                     /translation="MVYDLTMLEAFYSAYKGKVEHVRAVLKRPLTLAEKILYAHLFNEG
                     DLKNYKRGEDYVNFRPDRVAMQDATAQMALLQFMNAGKEKVAVPSTVHCDHLIQAYKGA
                     KEDIATATKTNEEVYDFLRDVSSRYGIGFWKPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRIIGVRLTGKLSGWTSPKDVILKLAGI
                     LTVKGGTNSIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPFDGRMATYLRATGRD
                     RIVELAEAVDCELRADQQVTDEPEKYYDRVIDIDLSTLEPYINGPFTPDAATPISEFAE
                     KVLLNGYPRKMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLSVASPLIINPGSEQIRA
                     TAERDGMMDDFMQIGAVIMANACGPCIGQWKRHTDDPTRKNSIVTSFNRNFAKRADGNP
                     NTYAFVASPELTMALTIAGDLCFNPLKDRLMNHDGEKVKLAEPVGDELPLRGFTSGNEG
                     YITPGGTKTAINVNPASQRLQLLTPFPAWDGQDILNMPLLIKAQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNAFNGETNNVWNRSTNTYGTVSGTAKMYKSEGIPSIVVAEE
                     NYGEGSSREHAAMEPRFLNVRVILAKSFARIHETNLKKQGMLALTFADKADYDKIQEHD
                     LLSVIGLPDFAPGRNLTVVLHHEDGTKESFEAQHTYNEQQIAWFRAGSALNAR"
     CDS             complement(9273..10028)
                     /locus_tag="ctg305_11"
                     /transl_table=11
                     /translation="LQESIGDAVLYHQPAVCQGVAELTLRQLIAPFLEASFGELHNVSF
                     VHQCHGRQMMVERILAGSPHKTFRALTGNRFHSKRRGLGEADFRHSHLVFQELIELFGF
                     GSTCLPLDSCIYILRIFTEHAHVHFFRCFHRRMNALIPTDRTQTNIQIQSLAQSHVQRT
                     DSTADRGRQRPLDADQIFLESLHRFIRQPRTCLVESAFARQHFFPFNPTFAAVCFLNSR
                     VHNGLHRRSHFRSYSVSGNIRYDRHIGHR"
     CDS             10456..11799
                     /locus_tag="ctg305_12"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEEMKEATRIDNELFPKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDVEDISHAIIKEKRFGFEEVAYLLLSGRL
                     PDKEELASFRELINDNMALEQKTKMNIIELEGNNIMNILSRSVLEMYRFDPDADDTSRD
                     NLMRQSIDLISKFPTIIAYAYNMLRHATFGRSLHIRHPQEKLSIAENFLYMLKKDYTEL
                     DARTLDLLLILQAEHGGGNNSTFTVRVTSSTGTDTYSAIAAGIGSLKGPLHGGANIQVA
                     DMFHHLQENIKDWKSVDEIDTYFTRMLNKEVYNKTGLIYGIGHAVYTISDPRALLLKEL
                     ARDLAREKGKEEEFAFLELLEERAIATFGRVKNNGKTVSSNIDFYSGFVYEMIGLPQEI
                     FTPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLDDLAYIPIKKR"
     CDS             complement(11815..11943)
                     /locus_tag="ctg305_13"
                     /transl_table=11
                     /translation="MFFLKQVTPDVQPGTTKMYNWGLPRRTCRDYRDVRLRLVIIA"
     CDS             complement(12196..12546)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acetyltransf_7"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg305_14"
                     /sec_met_domain="Acetyltransf_7 (E-value: 4.2e-09,
                     bitscore: 28.0, seeds: 2199, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRYPGVLIGRLGINKEYKHQGIGSDLMTFIKSWFIDAGNKTGCR
                     FLIVDAYNENIPLNYYLKNGFKYLFSTEAQEVEYTGFETGTHLKTRLMYFDLIDIIPYP
                     NNSSKDAIDGNY"
     CDS             complement(12835..12993)
                     /locus_tag="ctg305_15"
                     /transl_table=11
                     /translation="MAMEIKAIPTLKGKEAEHFVKAADKAYKNQNKQDFSKHVLEARAV
                     LKKAKML"
     CDS             13111..13926
                     /locus_tag="ctg305_16"
                     /transl_table=11
                     /translation="VTILFFFCYFCESQKKIKMSIAAFNLFLGVMSLTALIVFIALYFV
                     KAGYGIFRTASWGVAISNKLAWILMEAPVFLVMCWMWIHSERRFDPVILTFFVFFQIHY
                     FQRAFVFPLLLTGKSKMPLAIMSMGILFNLLNGYMQGEWIFYLSPEGMYHSGWFTSAWF
                     IAGSLLFFAGMLMNWHSDYIIRHLRKPGDTRHYLPQKGMYRYVTSANYLGEIIEWAGWA
                     ILTCSLSGLVFFWWTVANLVPRANAIWHRYREEFGSEVGERKRVFPFIY"
     CDS             complement(14070..14270)
                     /locus_tag="ctg305_17"
                     /transl_table=11
                     /translation="VPYLDACCRTFRVYSSGHFTQTGNDFRTQPQLTVEGKSALCHGCI
                     GYSRHPDSARSHRAVVIEQHL"
ORIGIN
        1 ggtggaactt ccggattgag tatcggacac gtttctcccg aagccgctgc cggaggtaat
       61 ataggaaaaa tagtagatgg agatatcatc gaaatcgaca ttcccgcccg aacgattaac
      121 gtgcgactaa cagatgaaga actggctgcc cgcccgatga ctcccgtcac ccgtgaccgt
      181 tacgtgccga agagcctgaa agcatacgcc agcatggtaa gctctgccga taagggagca
      241 gtgagattaa tagactgatc cacttcatta tccattatga atcatccatt atccattaaa
      301 gaactatgag taaggactta ataacaggcg cagaggcaat gatgcgctct ctggaacatc
      361 agggagtgac taccattttc ggttatcccg gcggttcaat catgcctacg ttcgatgccc
      421 tgtacgacca tcaaaataca ttgaaccata tcttggttcg ccatgaacag ggagctgccc
      481 atgcggcaca aggctacgcc cgtgtatcgg gtaaagtcgg tgtttgcttg gtgacaagcg
      541 gccctggagc aaccaatacg atcacaggta ttgcagatgc aatgatagac agtacgccta
      601 tcgttgtcat tgcaggacag gtgggaacag gctttcttgg aacagacgct tttcaggaag
      661 tcgatctcgt aggtatcact cagccaatcg ctaaatggag ctatcagatt cgccgtgccg
      721 aagacgtagc ctgggcaata gcacgtgctt tctacattgc cagtagtggt cgtcccggtc
      781 cggtggtact cgactttgcc aagaatgcgc aggttgaaaa aacgaaatac gagccgacaa
      841 agcaggagtt tatccgcagc tatgttccgg ttcccgatac agacgaagaa tcggtaaagg
      901 ctgccgccga actgatcaac aacgccgaac gcccgcttgt cttggtagga cagggagtgg
      961 aactgggaag cgctcaggaa gaactgcgta cctttatcga aaaggcggat atgcccgcag
     1021 gttgtacctt gctcggactt tccgcattgc ctaccgacca tccgttgaat aaaggaatgc
     1081 tgggtatgca cggaaatctg ggaccgaata tcaatactaa caaatgtgat gtactgattg
     1141 ctgtcggtat gcgtttcgac gaccgtgtga ccggtaatct ggctacttac gccaaacaag
     1201 cgaaagtgat ccattttgat attgatccgg cggaagtaaa taagaatgta aaggtagaca
     1261 ttgccgtttt gggcgactgc aaaaagacgc tggctgctgt gaccggactg ctgaaaaaga
     1321 accggcacac tgagtgggtc gatagtttca aggaatatga agcggtagag gaagaaaaag
     1381 tcattcgtcc cgaacttcat cctgcaacgg attcactgag tatgggcgaa gtggtgcgtg
     1441 cggtaagcga agcgacccgt cacgaagcca tattggtgac agatgtaggt cagaatcaga
     1501 tgatctctgc ccgctacttt aaatatacca aggaacgtag tatcgttact tcgggcggac
     1561 tcggcacgat gggttttggc cttccggcag ctatcggagc tactttcggc cgtcccgacc
     1621 gcatggtatg cgtatttatg ggtgacggcg gactgcaaat gaacattcag gagctgggta
     1681 cgattatgga acagaaagct ccggtgaaga ttatctgcct gaacaacaat tatctcggca
     1741 acgtgcgcca atggcaggcc atgttcttta atcgccgtta ttcatttact ccgatgctga
     1801 atccggatta catgaaaatc gcttccgcct acgatattcc ttccaaacgt gtcttttcac
     1861 gggaagaact gaaagcggcc atcgacgaaa tgctctcgac agacggaccg ttcctgctcg
     1921 aagcctgtgt ggtagaagaa ggcaatgtcc tgccgatgac ccctccgggc ggttcagtca
     1981 atcagatgtt gctggaatgt taatccttaa tttagaaagt tatgagtgat aagacattat
     2041 atacgattat agttcattct gaaaatatag ccggattgct gaatcaggtg accgctgtat
     2101 ttacccgtcg gcaaataaac atcgagagtt tgaacgtttc tgcttcttcc attaaaggag
     2161 tacataaata tacgatcaca gcgtggactg ataaggacac tattgaaaag gtggtgaagc
     2221 agatcgaaaa gaagattgat gtgattcagg cgcactattt tacggaagac gagatttatt
     2281 tccatgagat agccttatat aaggtatcta ctcctgcttt tcaggagact ccggaagcat
     2341 ctaaagtgat ccgcagatat aatgcccgca ttgtagaggt gaatccggta ttctctatcg
     2401 tcgagaagaa cggcatgagt gaagagatta cttcccttta cgaagaactt cgggctttga
     2461 aatgtgtgtt gcaatttgtc cgttcgggtc gtgtggctat tactaccagc tgcttcgaac
     2521 gtgtgaatga gttcctggac ggacaggagg cgaagtataa gcaaagtaaa aagtaacagg
     2581 agtaatgagt gaagaaaata aaatagggac ttatcagttt gtggcagagc cgttccacgt
     2641 agattttaac gggcgcctga caatgggcgt gctgggaaat catctgctga attgcgcagg
     2701 ttttcatgcc agcgaccgtg gatttggtat tgctacgctg aacgaggaca attacacatg
     2761 ggtgctttcc cgtctggcga tcgagctgga tgagatgcct taccaatacg agaagttctc
     2821 ggttcagaca tgggtagaga atgtctatcg tctgtttacc gaccgtaact ttgccgtcat
     2881 tgacaaggaa ggaaagaaga tcggctatgc ccgttccgta tgggcgatga tcaatctgaa
     2941 tacccgtaag cctgccgatc tgttggcatt gcatggagga agcatcgtcg attatatatg
     3001 cgatgaaccc tgcccgatag aaaagccttc gcgtatcaag gtgacaagca atcagcctgt
     3061 tgcgacgctg acggcaaaat acagtgatat cgatattaac ggacacgtaa acagtattcg
     3121 ttatatcgag cacatacttg acttgtttcc gatagaactg tatcagacga aacgtatccg
     3181 ccggtttgaa atggcgtatg tggctgaaag ttatttcgga gatgaactct ctttcttctg
     3241 tgatgaggtg agtgaaaacg agtttcatgt agaggtgaag aaaaacggca gcgaggtagt
     3301 atgccgttcc aaagtgatat ttgaataata tagagtataa aatcaattaa taacagatgg
     3361 cgcaagtcat caaaacaaaa aaacaaaaaa aaatggcaca gttgaatttt ggcggaactg
     3421 tagaaaatgt agttatccgt gatgaatttc cattggaaaa agctcgtgaa gtattgaaaa
     3481 atgaaacaat cgctgtaatc ggttatggcg tacaaggtcc tggacaggct ctgaaccttc
     3541 gtgataacgg tttcaatgta atcgttggtc aacgccaggg aaagacatat gacaaagcgg
     3601 tagctgacgg atgggttccg ggtgaaactt tgttcggtat tgaagaagct tgcgaaaaag
     3661 gtacgatcat tatgtgcctg ttgtctgatg cagcggtaat gtctgtatgg cctactatca
     3721 agccttacct gactgcagga aaagctcttt atttctctca tggttttgct attacatgga
     3781 gtgatcgcac aggtgtagtt cctcctgcag atatcgacgt aatcatggtt gctcctaaag
     3841 gttcgggtac atccttgcgt actatgttcc ttgaaggtcg cggcttgaac tcttcttacg
     3901 ctatctatca ggatgcaaca ggcaacgcta tggacagaac aatcgcattg ggtatcggta
     3961 tcggttcagg ttatttgttc gaaacaactt tcatccgcga agctacttcc gacctgacag
     4021 gcgaacgtgg ttcattgatg ggagctatcc agggtctgtt gctggcacaa tacgaagtgt
     4081 tacgtgaaaa cggtcacact ccttccgaag cattcaacga aactgtagaa gagctgactc
     4141 agtcattgat gccgttgttt gcaaagaacg gtatggactg gatgtatgct aactgctcta
     4201 ctacagctca acgtggtgct ctcgactgga tgggcccctt ccacgatgct atcaaaccgg
     4261 tagttgaaaa gttgtatcac agtgtgaaga ctggtaacga agcacagatt tcaatcgact
     4321 ctaactccaa accggattat cgtgagaaac tggaagaaga actgaaagca ttgcgcgaaa
     4381 gcgaaatgtg gcagactgcc gtgacagttc gtaaacttcg tccggaaaat aattaatcag
     4441 acttatacta tataagtttt tcaaaaggcg ggaaaagcgt attttcccgc tttttctatg
     4501 tagataccgg tcttttgagt aatagaaaaa ggatgaaagt agaaaaaaag attaaaagat
     4561 actgataata taggtgaaaa agagcattta tgattacctt tacggcaaca aataaaacag
     4621 aataggcaat gaagaaactt tttacttaca gaagatcgat acgtatgaag atgatttctt
     4681 ctttaataaa tagtatatca gaatgttaca ttaaaagata tttaagttat tctctaccga
     4741 atggtagctg taataccatt tcaagtcctt tttatatttc gtgttccatt agtgattcgt
     4801 tgatatgatg cagaatttta ttctgtagca ggaaaaagta tgcgttaaat tgaatttaag
     4861 acagagcttt tggaacagaa tttagtggga aaataacatt gtttgttttg tttgtaaatg
     4921 ggagtcctct ttcgtgagaa agggggcttc tttttttatc ccgatgattc aggaggatac
     4981 cgcttcctgc cggatatact gtatcagttt ccggtagaac gcatgcttgg taagagtggt
     5041 tgcatctccc aaaatcacaa gtttcatccg ggcgcgggta atggctacgt tcattcgtct
     5101 taaatcattc agaaaaccga tctgtccgtc ctcgttcgcc cggacgaggc tgataaagac
     5161 gacatcccgt tcctgtccct gaaagccgtc taccgtgttg accgtgatga ggctgcggaa
     5221 agggcggaga aaactgcttc ctctgatttt acttctcagg tattgcactt gcgccttgta
     5281 gggcgaaatc agaccaaagt cgatgctctc gtccaggatg cgtgctttgc cgatccggct
     5341 gatataggct tccagttctt gcagtaacaa gttggcttcc tgcttgttga tgcgcccgaa
     5401 gctctcgcct acaaactctt cgtggaagtc catttccgag gtatctatcc agttcatggg
     5461 agtgtcgaag tcaaggatac cccggttgcg cacttccggt gcggcttcca gttctccgtt
     5521 gtagaaccat tcggagggaa agcgcatgat tgcttcgtgc atccggtatt gcactttgag
     5581 cagcgagacg gcagaaggtt tttgctgcac gaccttttcc attagagtgt ggtccagtcc
     5641 gccacgggcg gcttcgatac atttgattgt aggagggagc tggcaatggt cgccggcaag
     5701 aatcacacgg tcggcctttc ggatggcgat ccaacaggcg gcttcgagtg cctgggcggc
     5761 ttcatcgata aataaggtgg ggaaacgccg tccgttgagc aaacggtgat tgctgctgac
     5821 cagcgtggaa gcaatcacac gggcactgtc gaaaagatcg gcgttgatca ggatttccag
     5881 ttcggtggca cggtcgcgga ggcggctcat ccggctgcgc attccttccc tttcggagta
     5941 acttccccga cgcatccggc tgcccatttc acggatcgat tttcggattc cccaaagttc
     6001 ggggtaggcc gaatgattct caaagcggcg ttcgtaagtg aaagaaagca ttttgtcatt
     6061 aacacgtgta gggttaccaa tgcggaggac aggcacaccc cggtctacca gtttctcgca
     6121 aatccagtcc acagccgtat tactttgggc gcagaccagc acctgcggtt cgcggtgaag
     6181 cgtttcgtaa atggcttcca cgagcgtggt agtctttccg gttcccggag ggccgtgaac
     6241 gatggcgaca tcgcgtgtgc ataacacttt gtttacggct gtttcctgcg tgctgttcag
     6301 ccacgggaaa cggacgggat ataattcgcg gaatcccggc ttttgtgttc ccagcaaggt
     6361 gtcccggagt tcggcaaggc ggttgccctt agcgcggatt gtgtcttcca gcgcttcgaa
     6421 catggcacga taggacgttt catcgaaata aagttgtaca cccagcacct cttccgtttg
     6481 cagttccagc aaggcgcccg cactgggaag cacgaccacc atccgttcgt cgtccgcata
     6541 actcaccgtt gcaatgaaat tcatgtaatt cacttttccg tcaaatgact gccggaaaaa
     6601 gcagacggga cgaccgaatt cgaaggaatg ctcgatttct ttattttcgg tgcgtgtaat
     6661 atctattaca agttgattta gagaattata gtaacttcga ccgggagagg cgggatacca
     6721 gcacagacca cgtttcactt tgcgggcgac acccattgtt tcagtctgcc gcttgaattc
     6781 ctccttttcg tgttcatact ccatgcgtag caggagttgc tgttgctgaa ggtcgatgat
     6841 tggacttttc ggatgattat tcataataga cgcaaaggta ataaatcttc ttcctgagac
     6901 gaaaatatat ttcattttgt taaacattcc tcgaacgccg ttcgttattt ttatagatag
     6961 actaaaaaaa ataaaagcaa tatggtgtat gatttgacta tgttagaggc tttttattct
     7021 gcttataaag gaaaagtgga acacgtgcgg gctgttttga aacgcccatt gacgttagcc
     7081 gagaagattc tgtatgccca tctgttcaat gagggcgatc tgaaaaacta caagcggggt
     7141 gaagactacg taaatttccg tcccgaccgc gtcgctatgc aggacgcgac tgcccagatg
     7201 gcattgcttc aattcatgaa tgcaggaaaa gaaaaagtgg ctgttccctc caccgtgcac
     7261 tgtgaccact tgatacaagc gtacaaagga gcaaaggagg acattgctac ggcaaccaaa
     7321 acaaacgaag aagtttacga ctttttgcgc gatgtatcct ctcgttacgg catcggcttc
     7381 tggaagccgg gcgccggaat cattcaccag gtagtgctcg aaaattacgc tttccccggc
     7441 gggatgatgg taggaaccga ctctcacact ccgaatgccg gaggactggg catggtggcc
     7501 atcggcgtcg gcggtgcgga tgccgtagac gtgatgacgg gtatggaatg ggaactgaaa
     7561 atgccaagga ttatcggtgt ccgcctgacc ggaaaactga gcggctggac ttccccgaaa
     7621 gatgtgatcc tgaaacttgc tgggattctg accgtaaaag gaggaacgaa ctccatcatc
     7681 gaatatttcg gaccgggaac agcttccctg tcggctaccg gcaaagcgac catttgcaat
     7741 atgggtgcgg aagtaggagc taccacttcg cttttcccgt tcgacgggcg catggctact
     7801 tatctgagag ccaccggcag ggatcgcatc gtggaactgg cggaagccgt ggactgtgag
     7861 ctccgtgcgg accaacaggt gacggacgaa ccggaaaagt actacgaccg tgtcatcgac
     7921 attgacttgt ccacgctcga accttatatc aacggccctt tcacaccgga tgccgctacc
     7981 cctatctctg aatttgcaga aaaagtatta ctgaacggct atccgcgtaa gatggaagtc
     8041 ggactgatcg gttcgtgtac caactcttct taccaagatc tcagccgtgc cgcatccctt
     8101 gcaaggcagg tgaaggaaaa gaatctgagt gtggcttccc cgctgattat caatccgggt
     8161 tccgagcaaa tccgcgctac tgccgaaaga gacggaatga tggatgactt catgcagatc
     8221 ggcgccgtga tcatggcaaa tgcctgcggt ccttgcatcg gtcagtggaa acgtcatacg
     8281 gacgacccga cacggaagaa ctcgatcgtc acatccttca accgtaactt tgccaaacgt
     8341 gcggacggca atccgaacac atacgccttt gttgcttctc ccgaactgac gatggcactg
     8401 accattgccg gtgatctttg cttcaatccg ctgaaagaca gactgatgaa ccatgacggc
     8461 gagaaagtga aactggccga acccgtagga gatgaactcc ccttgagagg tttcacctcc
     8521 ggcaatgaag gctatatcac ccccggcggg acgaaaacag cgatcaacgt caacccggct
     8581 tctcaacgcc tgcaactgct gactcctttc cccgcttggg acggacaaga tatactcaat
     8641 atgcccctgc tgattaaggc gcagggcaaa tgtactaccg accatatttc gatggcggga
     8701 ccgtggctgc gtttccgcgg acatttggag aatatttcgg ataatatgct aatgggagcc
     8761 gtgaatgcgt tcaatggcga aacgaacaac gtgtggaacc gttcgacaaa cacctacgga
     8821 accgtttcgg gcacagccaa aatgtataaa tccgaaggaa tcccctctat tgtcgtggcc
     8881 gaagaaaact atggagaagg ctccagtcgc gagcacgcgg caatggaacc ccgtttcctg
     8941 aatgtgcgtg tgattctcgc caagagcttc gcccgtatcc acgaaacgaa tctgaaaaag
     9001 cagggcatgc ttgcccttac ctttgcagac aaagcggatt atgacaagat acaggagcac
     9061 gacctccttt cagtcatcgg cttgccggac tttgctccgg gacggaatct gaccgtcgtt
     9121 ctccatcacg aagacggaac gaaagagagt tttgaagcgc aacatacata caacgaacag
     9181 cagattgcct ggttccgtgc cggctctgcc ttgaatgcca gataattaaa atgatagaaa
     9241 tgaacaaaat aaccatgcaa aaagatggta cgctatcggt gcccgatgtg cctgtcgtac
     9301 cttatattac cggagacgga gtaggagcgg aagtgactcc gtcgatgcag tccgttgtga
     9361 acgcggctgt tcagaaagca tacggcggca aacgtcggat tgaatggaaa gaagtgctgg
     9421 cgggcgaacg cgctttcaac gagacaggtt cgtggttgcc ggatgaaacg atgaaggctt
     9481 tccaagaata tctgatcggc atcaaggggc cgctgacgac ccctgtcggc ggtggaatcc
     9541 gttctttgaa cgtggctttg cgccaaactc tggatttgta tgtttgtctg cgtccggtcc
     9601 gttggtatca aggcgttcat tctccggtga aagcaccgga aaaagtgaac atgtgcgtgt
     9661 tccgtgaaaa tacggaggat atatatgcag gaatcgagtg ggaggcaggt actcccgaag
     9721 ccgaaaagtt ctatcaattc ctgaaaaacg agatgggagt gacgaaagtc cgcttccccg
     9781 agacctcttc ttttggagtg aaacctgttt cccgtgaggg cacggaacgt cttgtgcggg
     9841 ctgcctgcca gtatgcgctc gaccatcatc tgccttccgt gacactggtg cacaaaggaa
     9901 acattatgaa gttcaccgaa ggaggcttca agaaatgggg ctatgagctg gcgcaacgtg
     9961 agttcggcga cgccttggca gacggccggt tggtgataaa ggactgcatc gccgatgctt
    10021 tcctgcaaaa tacattactg attcccgaag aatattccgt gattgccacg ctgaacctga
    10081 acggagacta cgtttccgac cagttggcgg caatggtagg cggcatcggc attgctccgg
    10141 gagcaaatat taactacaag acggggcacg ccatttttga agcgactcat ggaaccgccc
    10201 ccaacattgc cggaaaggat gtcgtgaatc cttgttctat cattctttcg gcggtgatga
    10261 tgcttgaata tctgggatgg aaagaagcgg ccgcgcttat cgaaaaggcg ttggaacaga
    10321 gtttcctcga tgcccgtgcc acgcacgatc tggctcgctt tatgccggga ggtacatccc
    10381 tgtctaccac cgctttcaca cgcgaaattg tggaaagaat cgaaaagtaa atgtaacgat
    10441 taaaaacgaa gtattatgaa gaaagagtat ttgatttaca agctctccga ggagatgaaa
    10501 gaggcaaccc ggattgacaa tgaattgttc cccaagtttg acgtgaagcg tggactgcgt
    10561 aatgaagacg gcaccggtgt attggtaggt ctgacaaaga ttggtaatgt ggtaggttac
    10621 gaacgtatcc ccggcggcgg tctgaagcca attccgggaa aattgttcta tcggggctac
    10681 gatgtggaag acatttccca cgccatcatc aaggaaaaac gtttcggctt cgaagaagtg
    10741 gcttatctgc tgctttccgg tcgcctgccg gacaaggaag aactggcttc tttccgcgaa
    10801 ctgatcaatg acaatatggc gctcgaacag aagacgaaaa tgaatattat cgagctggag
    10861 ggaaataata tcatgaatat tctttcgcgc agcgtactcg aaatgtatcg tttcgatccc
    10921 gatgccgacg atacttcccg cgataatctg atgcgccaga gtatcgatct tatctccaag
    10981 ttcccgacca tcattgcgta tgcttataat atgctccgcc atgctacatt cggtcgttcc
    11041 ctgcacatcc gtcatccgca ggagaaactc tctattgccg agaatttcct ctatatgctc
    11101 aaaaaagatt atacggaact ggatgcccgt acgctcgact tgctattgat tttgcaggca
    11161 gaacacggcg gtggtaacaa ctcgactttc acggttcgtg tgacttcttc caccggaaca
    11221 gatacatatt cggccatcgc cgcaggtatc ggttcgttga aaggcccgct tcacggaggc
    11281 gcgaatatcc aggtggccga tatgttccat cacttgcagg agaatatcaa ggactggaag
    11341 agcgtggacg agatagatac ctatttcaca cgaatgctga ataaggaagt gtataataag
    11401 accggattga tttacggtat cggtcatgct gtttacacga tttccgatcc tcgtgcgctg
    11461 ttgctgaaag aactggctcg cgaccttgcc cgtgagaaag gaaaagaaga ggagttcgct
    11521 ttcctcgaac tgcttgaaga gcgtgccatc gctactttcg gacgtgtgaa gaacaacgga
    11581 aagacggttt ccagcaatat cgacttctat tcgggcttcg tatatgagat gattggtttg
    11641 ccgcaggaga ttttcactcc gctgtttgcc atggctcgta ttgtcggctg gtgtgcgcac
    11701 cgcaatgagg aactgaactt cgaaggcaaa cgcattatcc gtccggctta taaaaatgtt
    11761 cttgatgatc tggcttatat ccccatcaag aaacgctgat aagaacaaat ccttttatgc
    11821 aataataact aacctcagac gtacatctcg gtaatccctg catgtacgtc ttggtaatcc
    11881 ccagttgtac atcttggtag tacccggttg tacgtctggg gtgacttgtt tcaggaagaa
    11941 catccgatgt tcatttaaca tttaacactt tgcggttgct gtatttttca tccgatggag
    12001 gctaaggcat ttatcgttgg tagaaagggc acagcctggc aggtagaaac gcccttttaa
    12061 cgctacgtta aaagggcgtt tctacaaccg atgaattata cattctattt ctttggatat
    12121 cagtgaacta tgatctttcc ctttgctgga ggagagatta tggacaggtg acctgttgag
    12181 aacaaacttg ttattttaat aattaccgtc gattgcgtct ttgctgctat tattgggata
    12241 aggtataatg tctattaaat caaaatacat taagcgtgtt tttagatgcg ttccggtttc
    12301 aaagcctgta tattccactt cttgcgcttc cgtagagaaa aggtatttga aaccgttttt
    12361 cagataatag ttcagaggaa tattttcatt gtaagcgtca acaattaaaa agcgacaccc
    12421 tgttttgttt cccgcatcaa tgaaccatga ttttatgaaa gtcatcagat cactgcctat
    12481 gccctgatgc ttgtattctt tattgattcc aagtctgccg attaatacac ccggatagcg
    12541 gcgcatttgt ttggctcggg gaatgtcttt ctgaactttc ttttccctgc tgttggggag
    12601 gatatttact ctgatactat cgttagaaac agtgaaggca catactatgt ccgaaggctt
    12661 tttatctgaa cgaaaacagt aactttttcc taatagctgt gcattataga gaggagcatc
    12721 gttatgaaag aagtcgtcta agtcttggtg cccacatgag aaagggtcac attctttaat
    12781 cgtatcttca tcaagtacgg caaaagtaca tttctcaaaa agaaatccca tgttttataa
    12841 cattttagcc tttttgagca cagcacgggc ttccagcaca tgtttgctga agtcttgttt
    12901 gttttgattt ttataagcct tgtccgctgc cttaacgaag tgttccgctt cttttccttt
    12961 taaggtcggt atggctttaa tttccattgc cattgctttt tctattattt agttcataac
    13021 caactgcaaa gatagctgat ttttaatgaa taaacaaaga atgccggaag tctgttgtcg
    13081 tttgatctgt tttttatttg agttattttt gtgaccattc ttttcttttt ttgttatttt
    13141 tgtgaatctc aaaagaaaat caagatgagt atagctgcct ttaatctatt tttgggcgtc
    13201 atgagtctga ccgctctgat tgttttcatc gccctctact ttgtgaaagc cggttacggg
    13261 atatttcgca ccgcctcctg gggagttgcc atttccaaca agctggcgtg gatactgatg
    13321 gaagcccccg tatttctggt catgtgctgg atgtggatac actcggaacg tcgttttgat
    13381 ccggtcatac tgacattctt tgtcttcttt cagattcatt attttcagcg cgccttcgtc
    13441 tttcccctgc tactgaccgg aaagagtaaa atgccgctgg caatcatgtc gatgggaatc
    13501 ctgttcaatc tattgaacgg ctatatgcag ggtgaatgga tattttatct ctcacccgag
    13561 ggaatgtatc attccggctg gttcacttcc gcatggttta ttgcgggcag tctgcttttc
    13621 tttgcgggca tgttgatgaa ctggcattcg gactatatca tccgccattt gcgcaaaccg
    13681 ggggataccc gtcattatct gccacaaaaa gggatgtacc gctatgtcac ttccgccaat
    13741 tatctgggcg aaatcattga atgggcaggc tgggcaatac tgacttgttc actatccgga
    13801 cttgtattct tctggtggac agtggccaat ctcgtccccc gtgccaatgc aatctggcat
    13861 cgctaccgtg aagaatttgg ctcggaagta ggcgaacgca aacgtgtatt tccttttatc
    13921 tattgatttg aaataaatta tctattgaca taaaatagcg tactatggaa tctaaacttt
    13981 tcacccctgt tactttcggt ccattgacgc tgcggaatcg tacgatccgc tctgccgctt
    14041 ttgaaagcat gtgtcccggt aacgcccctt cacaaatgct gctcgattac caccgctcgg
    14101 tggctgcggg cggagtcggg atgacgactg tagcctatgc agccgtgaca caaagcggac
    14161 tttccttcga ccgtcagttg tggctgcgtc cggaaatcat ttccggtttg cgtgaagtga
    14221 ccggagctat acacacggaa ggtgcggcag caggcatcca gatagggcac tgcggaaata
    14281 tgtcccataa aaagatttgc ggaaccactc ccatttcagc ttctaccggt ttcaatctct
    14341 attctcctac attcgtgcgt ggcatgaaga gagaagagtt gccggagatg gccagagcct
    14401 acggacgggc tgtccacttg gcacgggaag ccggct
//
