LOCUS       gnlProkkaLPLLDEMI_558  13244 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LPLLDEMI_558.
ACCESSION   gnlProkkaLPLLDEMI_558
VERSION     gnlProkkaLPLLDEMI_558
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 10:39:11
            Original ID  :: gnl|Prokka|LPLLDEMI_558
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13244
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..186)
                     /locus_tag="ctg558_1"
                     /transl_table=11
                     /translation="MNNVAEHAREQKAGMKCPQCGAFIETSIFELLTSNALQCPSCHLR
                     LNIDRMKSKAAFDALRK"
     protocluster    1..13244
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[4575:7005]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4576..7005
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..13244
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13244
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             complement(183..797)
                     /locus_tag="ctg558_2"
                     /transl_table=11
                     /translation="MDNKKVRSTSSQVMELQQLIAGPLIATIEADSLSSQRYLDYLMKI
                     AFESYDPVTGRTGKIRMLTFNYQSQDAGGGRTQSVSIPILTLVPLPLLQVQEADFDFDI
                     KILDALSETAEEKFSLEEGKSVNEPQSGGGFKLRASLAPKQGEGSSTSNVQQSLSANMK
                     VKVKMRQADMPAGLSNLLHLTASNMQVEETEAEEITEGGNK"
     CDS             complement(814..1626)
                     /locus_tag="ctg558_3"
                     /transl_table=11
                     /translation="MAQLSSVIGSILRDIVSAQHEANLYSLSLGDSYGKDGKAKDFQLP
                     NVMVSDMELDLKYGVKSASESQQQFNIKYDKFRQFLKELCEQVARVAISSAVTTVMTSD
                     IERNEGEKHFFERLKKENKLHQEFCTFLSRNMRNSFRNNLYDAVDSSNGSVNNDVVISR
                     LTDVVRKKFLYDTDLDDLFAGEDGEKLRDTAEKNIIKAMEAIVKKLSVDANFKSLHSFP
                     QLDVAITADELMNMPEEAIHSFKIKFSPRNYSVSQTDDDSLLEDFVMR"
     CDS             complement(1655..2527)
                     /locus_tag="ctg558_4"
                     /transl_table=11
                     /translation="MAVDKTPSQVATSALQAIPFGSIIGGPLKACVEAQALAAKTTWEF
                     IQNVGINVNPETGEKTAVNVSFSFIQGGRLVQLNIPLLTIVPIPYIAIREVDINFKANI
                     SASSSTTAETNESVSKDAALKASASMRFGCFKMNADMNASYSSKKDSKATSDSKYSVEY
                     TMDVAVKAGQDSMPAGLSKILELLGNSLDVSDPAGTLEVNSNLLLIENGKETVRLIATY
                     KDGSGLLAPDKLTITGTGANAADFKVSGDSKIIDLPEGTYTIKAEGSKKEVIVEVKKDT
                     ATPQEEVTE"
     CDS             complement(2661..3062)
                     /locus_tag="ctg558_5"
                     /transl_table=11
                     /translation="MKENSIKPYCYCGESESSLVDNAIFVYFGDEYRRVLLDEILWLEA
                     SGSYCVLCMENGAEITVSYPLDRIFNNDLPRGKFQRIHRSYAINVFKVTGFAGNYVHIG
                     KKMLPVSESHKKNFLACFHKIYSKRALGK"
     CDS             complement(3103..3447)
                     /locus_tag="ctg558_6"
                     /transl_table=11
                     /translation="MGKNRNHYSFFLYFVFIIFVLLGCRPVRVQMPDGMYGRWKSSAGR
                     PDITLGTDSIGSFAIVHHRIYDGKICPVRYPLHLNSPTKGYIRAEGCILFYYDSLKCVL
                     YFSPGGDYTQ"
     CDS             complement(3678..4571)
                     /locus_tag="ctg558_7"
                     /transl_table=11
                     /translation="MQTENFTLGKKELLILLGLTLVLPFPINWALIELNPLTLMAGADD
                     VPTWIGFGGSYIGGIIGGVISIMILNKTLQQTGVLHHDLKLLQLDTIIYTQQQDWFTGF
                     KQELAENLKSIDLYVLNTVVSSISMKNYAYAKEVLTEINKGLEYQMVAASFSFTSTHLS
                     SEEKKYMNLVRRVQTEYSSFIKDILYYIPLAETISSRKKLNYDQLMDYTLSQYDYLQGQ
                     EGESTASGAIIPRVMEIDPSDDIRKELERIMEERLTGRTYLYHLKSDLAEATHQLIIYE
                     ENRINSILHKPEREMN"
     CDS             complement(4576..7005)
                     /NRPS_PKS="Domain: AMP-binding (12-401). E-value: 2.3e-83.
                     Score: 271.9. Matches aSDomain:
                     nrpspksdomains_ctg558_8_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (509-568). E-value: 2.7e-10.
                     Score: 32.6. Matches aSDomain:
                     nrpspksdomains_ctg558_8_PP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score: 260;
                     E-value: 5.6e-79)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg558_8"
                     /sec_met_domain="AMP-binding (E-value: 2.2e-88, bitscore:
                     286.2, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 5.8e-11, bitscore:
                     32.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNIQKNLSRSLSTWGDKPAVVAKDGTVSYQMLERYSANIAQSI
                     RQRLSVTDPSGLRNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAEN
                     ADMVLLLTDSSNEVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPDDCAYIIYTSGTTGNP
                     KGVRISYRNLDTFTRNLIDKKLYHLSDPANRYLAFASISFDASILELMMCIPAGGTLIL
                     AGEDERRDISLLDELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNR
                     LKQQPYRLMNVYGPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGAT
                     GELCLGGPQVSLGYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVK
                     IRGFRIELTEIAERLNRDPDVERAHVVVVERNGRQLLGAYLQPSVSGNFHPEEVKERLR
                     AELPYYMIPNLWQVVDHFQRTINDKIDVRALPAFTSLELKYVPPVHPGEVILCGILKEM
                     LGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPINVSAVYTARNLRRLLLVPRHEP
                     IYWYRQQNLKKPVIILVCGSAYFNHLYFNLADRLYPKYDFLVVDAIYDHFNKVATDIPE
                     LLEYYVRTVQPMIRERTVYALTGFCMGAELAVGLAEMLHRSMGIMPKVFALDGQAWQNP
                     ALCQNYPLLVFPGDTDEMVRERNEIINIYFRTTPNLIYQGEVIVLLSGLFHQQAGLSPE
                     ESWTEENYRIFRTEYDNCERLWNKYYPNAPVLRLPADHWHFLEGESLEQLITVFLK"
     aSDomain        complement(5302..5478)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg558_8_PP-binding.1"
                     /evalue="2.70E-10"
                     /label="ctg558_8_PP-binding.1"
                     /locus_tag="ctg558_8"
                     /protein_end="568"
                     /protein_start="509"
                     /score="32.6"
                     /tool="antismash"
                     /translation="LCGILKEMLGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPI
                     NVSAVYTARNLRRL"
     aSModule        complement(5302..6969)
                     /complete
                     /domains="nrpspksdomains_ctg558_8_AMP-binding.1"
                     /domains="nrpspksdomains_ctg558_8_PP-binding.1"
                     /locus_tags="ctg558_8"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(5776..5838)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg558_8_0004"
                     /evalue="1.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg558_8"
                     /protein_end="410"
                     /protein_start="389"
                     /score="36.2"
                     /tool="antismash"
                     /translation="FIGRKDTQVKIRGFRIELTEI"
     aSDomain        complement(5803..6969)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg558_8_AMP-binding.1"
                     /evalue="2.30E-83"
                     /label="ctg558_8_AMP-binding.1"
                     /locus_tag="ctg558_8"
                     /protein_end="401"
                     /protein_start="12"
                     /score="271.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LSTWGDKPAVVAKDGTVSYQMLERYSANIAQSIRQRLSVTDPSGL
                     RNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAENADMVLLLTDSSN
                     EVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPDDCAYIIYTSGTTGNPKGVRISYRNLDT
                     FTRNLIDKKLYHLSDPANRYLAFASISFDASILELMMCIPAGGTLILAGEDERRDISLL
                     DELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNRLKQQPYRLMNVY
                     GPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGATGELCLGGPQVSL
                     GYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVKIR"
     CDS_motif       complement(5911..5997)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg558_8_0003"
                     /evalue="1.20E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg558_8"
                     /protein_end="365"
                     /protein_start="336"
                     /score="27.3"
                     /tool="antismash"
                     /translation="LGATGELCLGGPQVSLGYIGSVQLNEKSF"
     CDS_motif       complement(6499..6555)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg558_8_0002"
                     /evalue="1.50E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg558_8"
                     /protein_end="169"
                     /protein_start="150"
                     /score="26.8"
                     /tool="antismash"
                     /translation="AYIIYTSGTTGNPKGVRIS"
     CDS_motif       complement(6736..6777)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg558_8_0001"
                     /evalue="3.50E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg558_8"
                     /protein_end="90"
                     /protein_start="76"
                     /score="11.0"
                     /tool="antismash"
                     /translation="LAIFRLGATYLPID"
     CDS             complement(7018..9384)
                     /gene_functions="transport (smcogs)
                     SMCOG1082:TonB-dependent siderophore receptor family
                     (Score: 167.8; E-value: 8.8e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg558_9"
                     /transl_table=11
                     /translation="MKRCLLYILCCFGVVQLSAQPADNIRNSFVKAETFYKSGDIDEAC
                     RILEENLSSFQGTMHTEACRLAALCCLALDRFPEAEKYVSLLLKDEPYYYISLQDPERF
                     ADMVRKHRETKVTLVTASQQVETPEEAPVPVTLITEEMIRAIHARCLRDVLIAYVPGIS
                     GLSSNEEMNLAMRGVYSPEQENILIMQDGQRLNSYITNAVSPDYGISLAKVKQIEVLRG
                     PASSLYGSVALTAVINIVTKDGVDVRNGSISVSAGNRGQLAADLLLGKHDMNMDFMAWF
                     SLYRATGESVFVPAEKQYALYPRDGFIRLDNYSGFPAMDGGIKLQRGNLLFSFSMNYAK
                     KRQPYSMWLFSSPYSYERFRTFDGSGPGYSRWSAREQAVYSRTWQRITFSTAFYTDWNK
                     NVHYETSGDTLQDYPIFPNYDYQPIIYPTRGAFQYIRWMDFNVGFNGRVNYAYDWGKLG
                     KGNMLGGVEWNRYTLYDSEYLEGMNFKEIVRTWIEKRLYTGHEMNTDAFLQIKHNLHKN
                     WIVNAGIRYDYKRRSNKRTLQAFSPRLSLIYLRNGLNIKASYSRAFVDAPYYYRNNETD
                     TYSGGENLQAEYLSSYQVTCAYHHSPSHIDVECNLFYNRASHFLFTQPETRVYENAGSL
                     DMGGVEVVARYKADRLSLDGNLCFQKVLNYTNFFVTDGSVNNVPGFSMNLVANYFLLKK
                     KVQSWSAHLKLNCSSHCYTQVSVLEDGLNGDATNYTVRLPGYAVFSFTTRYKYKRIEGS
                     LGIENLFNNRYECGGATVPIRQKGRWISASILYNF"
     CDS             complement(9381..10214)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 120.8; E-value: 1.5e-36)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg558_10"
                     /transl_table=11
                     /translation="MEKNISQEKRIEELEARLKEQEKLGSLGLLSAGIAHEIQNPLNFV
                     INFSKLSGQLLADLADRVDEAKARIPEAELEDIKDILSGLRENVDKIKEHGDRAISIIR
                     GILLYSRGKEDEFMPTQIQKLTKEYVWLAYHAMRANYKNFNIAIREDYAKDIPSIRLIP
                     QDFSRAVLNVMNNACYAVWKKWQNAPEGYSPEIMVTLEKLDKRIVLSIRDNGEGMGPEV
                     KRKLFDSFFTTKPVGQGTLGMAIVRDIIENKHHGKVLFDSVLHEYTCFRFIIPIA"
     CDS             complement(10237..13074)
                     /locus_tag="ctg558_11"
                     /transl_table=11
                     /translation="MKKIVSLIMCLCSVYANSQEGIPFFVNYPASVYQAHNRNFDVVCD
                     SCGNVYFANFEGILHYDYSRWETIYTPGFSRVTRLFRDSEGRIWVGGYNVFGRIERDGR
                     GCITLRTLLSDLDTNFLGELEDMAEIDKRIYLKATSGGYYTVQSDSILAPVQVLPAQLQ
                     ERWRNQSSVSMNRAFSLPGGETISINSAHGLIMDDSGKKERFSVTERNGLCSNAVSGIA
                     ADGRGNLWGATDNGVFHVFIPSLFSRYTSGEGLKGEVISAVSYKGMIYTGTLQGLYVLK
                     QNTFVPVQGISQACWQLCLSPQGELYAASGDGVYVIRDYNHSEKLTDMAAYSLAFIGHT
                     NLLMGTMDGIYQYSADEERIKKISDVEKVVRLEVKKDRSVWAKTLYGEIYLREEGKSSF
                     VLQDRESEEIMTEYTDNDGCHWQTNLKGKEVQVHHSQIDTEKFNQCLYAIRNYVVRVIY
                     IEEDRAAWFGGDFGLIRMDLEKARTFTPVVPRIYLREVCLNRDSVYWGGDLPEESGGAD
                     WQINSTVPRLGNDVRSIRFSFATDAPCFTGSNEYRYRLVGYDPEWSSWDSGTVKEYANL
                     SSGTYTFCVRARDIYGTESEMKQFRFSLLPPFYLQWYCLILYAVAFGMLLFVLFKWRMR
                     SLLKEKERLEALVGQRTKQLVQQKNEIEEKSLKLEKALKELGQAQDELVRQEKMATVGK
                     LTQGLIDRILNPLNYINNFSHLTSGLLKDLYQNLESVKELLDEDTYLDSVDVINMMRDN
                     LEKIEEHGSNTTRVLKAMEEILRDRNRQLEKTELIGLCRKDMELLSSYYQKEITAMHIA
                     VRTSLPDNPLFIDGNAEQLGKTIMSLLNNGMYAIAKKYGKKAYPAEIGLALESKDGQAV
                     IRLYDNGVGIEQSILDKIFDPFFTTKTTGEAAGIGLYLSKEIILNHHGQIAVRSEKDEL
                     TEFTITLPLWEEKSV"
     CDS             complement(13071..13244)
                     /locus_tag="ctg558_12"
                     /transl_table=11
                     /translation="MFMGDEQGRLYRVPISPDHMAAVVRQGLQRDFTREEWEYYIGKQI
                     PFESYYLKTYQP"
ORIGIN
        1 tttccgcaat gcgtcaaaag ctgctttcga cttcatgcgg tctatgttca aacgcaagtg
       61 acaggatgga cactgcaagg cattggatgt caataattca aagatcgatg tctcaataaa
      121 tgctccgcat tgcgggcact tcatcccggc tttctgttca cgggcatgtt cggctacatt
      181 attcatttat ttcctccttc cgttatttct tcagcttcag tttcttctac ttgcatattg
      241 ctcgccgtca gatgtaacag attagacaac cccgcaggca tatctgcctg acgcatcttc
      301 actttcactt tcatatttgc cgacaagctc tgctgcacat tcgaagtgct gctgccttct
      361 ccttgtttgg gagccagtga agcccggagt ttaaatcccc ctccactttg cggctcattc
      421 acgcttttac cttcttccag tgaaaatttc tcttcagctg tttccgacag tgcatccaga
      481 attttaatat cgaaatcgaa atctgcttcc tgtacttgca acagtggcag aggtaccaat
      541 gtcagtatcg gtatacttac actttgcgtt cttcccccac cggcatcctg actctgatag
      601 ttgaacgtaa gcatacgtat cttaccggtc cgtcctgtca caggatcata ggattcaaat
      661 gcgattttca tcagataatc cagatatctt tgtgaagata atgaatccgc ttcaatagtt
      721 gcaatcaaag gaccggcaat caattgctga agttccatta cctggctact agtgctccta
      781 actttcttat tatccatatt atatcatttg attttatcgc atcacaaaat cttccagtaa
      841 cgaatcatca tccgtttgac tgactgaata attgcgaggg ctgaacttga tcttaaaact
      901 gtgtatcgct tcttcaggca tattcatcag ttcatcagcc gtgatggcca catccagctg
      961 tggaaatgaa tgaagacttt taaagttggc atctaccgac agctttttta caatagcttc
     1021 catcgctttt ataatattct tttcagcggt atcacgaagt ttttctccat cttctccggc
     1081 aaaaagatca tcaagatctg tatcgtaaag aaatttttta cgtacgacat ctgtcagtct
     1141 gctaatcaca acatcgttat tcacagaacc attactactg tctacggcat catagagatt
     1201 atttcggaaa gagtttctca tattacggct cagaaaagtg cagaattcct gatgaagttt
     1261 gttttctttt ttaagccgtt caaagaagtg tttctctcct tcatttctct ctatatccga
     1321 agtcatcact gtggtgacag cactgctaat ggctaccctg gcaacttgtt cgcacagttc
     1381 tttaaggaac tgacggaact tatcatactt gatattaaac tgttgctgac tttccgatgc
     1441 acttttcaca ccatatttca aatccagttc catatcgctt accataacat taggcaattg
     1501 aaaatctttc gcctttccgt cttttccgta agagtcgcca agcgacaacg aataaagatt
     1561 tgcttcgtgt tgtgccgaaa cgatatcacg caatatagag ccgattactg aacttaactg
     1621 agccataata tgatttttta agttttaatt aacgttattc cgttacctct tcctggggag
     1681 ttgccgtatc ttttttcact tcgacaatca cttccttctt gcttccctct gctttgatag
     1741 tatatgtacc ttccggcaag tcgataatct tactgtcacc acttacctta aagtcggccg
     1801 cattggctcc ggttcctgta atagtcagtt tgtcaggagc caacagaccg cttccatcct
     1861 tataggtggc aatcaaccgt actgtttctt taccattttc aataagcagc aagttgctgt
     1921 tcacttccag tgtaccggca ggatcggaaa catccagtga gttacccagc aattccagaa
     1981 ttttagaaag acctgcgggc atactgtctt gtccggcttt tacagccacg tccatggtat
     2041 actctacact gtacttagaa tcggaagttg ctttagaatc cttcttcgat gaatagcttg
     2101 cattcatatc cgcattcatt ttgaagcatc cgaatctcat actggccgaa gccttcaaag
     2161 ccgcatcctt agatacagat tcattcgtct ctgccgttgt tgaagaggaa gcactgatat
     2221 tagccttaaa attaatatcc acttcacgga ttgcaatata agggatagga acaatggtca
     2281 acaacggaat attcaactgg accaaacgtc cgccttgaat gaaagagaaa gaaacattga
     2341 ctgctgtctt ctcaccggtt tcgggattaa catttatacc tacattctga ataaattccc
     2401 aagttgtttt tgctgccaaa gcctgtgctt ccacacatgc tttcaacgga ccaccaataa
     2461 tagaaccgaa cggaatcgcc tgcaacgcac tggttgcaac ctgcgacggt gttttgtcaa
     2521 ctgccataat aattgttttt ttaaattgtt acttaattgt ttttctcttt tgtaagctta
     2581 cgatgcaaag gtagtgcaca tcccttgcgt agtaaatttt taattttaaa cgaaactggt
     2641 tttcttttta gttacctcca ttattttccc aatgcacgct ttgagtaaat tttatggaaa
     2701 caagctaaaa aattcttttt gtgagattcg ctgaccggca acatcttctt tcctatatgt
     2761 acatagttac ctgcaaatcc ggtcaccttg aacacattga tagcgtaaga acgatgaatt
     2821 ctctgaaact tgccgcgagg aaggtcatta ttgaagatcc gatccaaagg atagctgact
     2881 gttatctctg caccgttctc catacagagt acacaataac tgccggatgc ttccagccat
     2941 aagatttcat ccagaagtac tcttctgtat tcatcaccaa aataaacaaa aatagcatta
     3001 tcgaccaatg agctttctga ctcaccacaa taacaatacg gtttgattga attctctttc
     3061 ataaattatt tattgttagt taactgaagt gtttgcatgt aattattgtg tataatcacc
     3121 tccgggagag aagtataaaa cacatttcaa actgtcataa taaaacagga tgcaaccttc
     3181 tgcacggata taccctttag taggtgaatt aagatgaagc ggataacgga caggacaaat
     3241 ttttccgtca taaatacggt ggtgaactat agcgaagctc cctatgctgt ctgtccctaa
     3301 tgtaatatcc ggacggcctg cagaagattt ccatcttcca tacattccgt ccggcatctg
     3361 tacccggaca ggtcgacaac ccaaaagcac aaatatgata aagacaaaat acaaaaaaaa
     3421 gctgtaatga ttcctatttt tacccatata taaaactttt aaatttcatt tagtgcaaaa
     3481 ataggatttt attaatctat ggaaatttta cattctgact agatctcttt tttttccgaa
     3541 taccggatta ttttttctaa aactattcct atataaaaga taaatcaagt ttaaagtaac
     3601 ttttcatcca aataaaaaca aatataaatt catttttaat actgaaataa aaaaatacca
     3661 tattatatta atatatgtca attcatttct ctctcaggtt tatgcagaat agagtttata
     3721 cggttctctt cataaataat taattgatgc gtagcctctg caagatctga cttcaggtga
     3781 tacaaatagg tacgcccggt taatctttct tccattatcc gttctagttc tttccgtata
     3841 tcatcagatg gatcgatttc cataacacgc ggtatgatgg ctcccgaagc tgtagactcc
     3901 ccttcctgac cttgcaaata atcatattgg gacaaagtat agtccatcag ctgatcatag
     3961 tttagttttt tcctggaaga tatcgtttct gccaaaggaa tatagtaaag aatatccttg
     4021 ataaaagagc tatattcagt ctgtacgcgg cgtaccagat tcatatactt tttttcttcg
     4081 gatgataaat gcgtagaagt gaaagaaaag gatgcggcaa ccatctgata ttcgagccct
     4141 ttattgattt ctgtcaacac ctctttggca tatgcatagt ttttcatgga tatagacgaa
     4201 acaaccgtat tcaacacata caaatcaata gatttgagat tctctgccag ttcttgtttg
     4261 aaaccggtaa accaatcttg ttgctgagta taaattatgg tatctaactg caggagtttc
     4321 aaatcgtgat gaagtacacc tgtctgctga agtgtcttgt tcagaatcat aatcgagatg
     4381 acccctccga tgattcctcc aatataactg ccgccgaaac caatccaggt gggcacatcg
     4441 tctgcacccg ccatcagagt caacggattc agttcgatta atgcccaatt gattggaaaa
     4501 ggcagtacaa gagtcaagcc aagcaaaata agaagctctt tcttacctaa agtgaagttt
     4561 tcagtctgca taaatctact tcaaaaacac agttattaat tgttccaatg attccccttc
     4621 taaaaagtgc caatgatctg ccggcaatcg caaaacagga gcgttcggat aatatttatt
     4681 ccataatctt tcgcaattgt catattctgt ccggaatata cgataatttt cctccgtcca
     4741 cgactcttca ggagacaatc ccgcctgttg atggaacaat ccggacagca aaacaataac
     4801 ctctccctga taaatcagat taggagtggt tcgaaaataa atatttatga tttcgttccg
     4861 ttcacgtacc atttcatcgg tatctccggg aaataccaac aaaggataat tttgacagag
     4921 agccggattt tgccaagcct gtccatccag agcaaaaact tttggcatta tccccatgga
     4981 gcgatgtaac atttcggcca ggccgacagc cagttcagct cccatacaga agccggtaag
     5041 cgcatagacg gtacgctccc ggatcattgg ctgaaccgtc cggacataat attccaacag
     5101 ttccggaata tccgtggcca ctttattaaa atgatcgtag atagcatcta caactagaaa
     5161 gtcatatttg ggataaaggc ggtcggccaa attaaagtac aaatgattaa aataggcaga
     5221 tccacaaacc agaatgatta cgggtttctt caggttttgc tgcctgtacc aatagatagg
     5281 ttcatgccgc ggaacgagca ataatcggcg cagattacgg gcagtataaa ctgcagatac
     5341 gttgatggga catccttttt tattggcctc ggtaacaagc ctcaacatat ccagcgaagt
     5401 taatcccaga tcatcaatca aatcggcctc aacactgact tgaggcaaac ctaacatttc
     5461 cttcaaaatt ccacataaga taacctcccc cggatgaaca ggaggaacat acttcaactc
     5521 caatgaagta aaagccggga gcgcccggac atcaatctta tcatttatag tacgctgaaa
     5581 atgatctacc acctgccata aattgggtat catgtagtaa ggaagttctg cacgcaaacg
     5641 ttctttgacc tcttccggat gaaagttacc ggagactgag ggttgcaaat aagctcccaa
     5701 taattgacgc ccattccgct caacaactac tacgtgggct ctctccacgt ccggatctct
     5761 attcaatcgt tctgctattt cagtcaattc gatacgaaag ccacgtattt tgacctgagt
     5821 atcttttcgc ccgataaacc gtattgaacc gtccggttgc tgctgtacca agtcacctgt
     5881 cctgtacaac cgttctccat cgtacgagat gaatgatttt tcattcagct gaacactccc
     5941 aatatatccc agcgaaacct gaggtcctcc caagcaaagt tctcctgtag ccccaagagt
     6001 tgtctgttgg aggttttcag acaaaacata acagacagtt cccttgagcg gatagccaat
     6061 atcgtcatac gacgtatctt tgcctacaat ccgtatggta ctgagtacgg tattctctgt
     6121 cggtccatat acattcatca accggtaagg ctgctgtttc agcctgttaa ataacttttc
     6181 accaatagcc tccgcaccaa agagcagagt cttaaaggat ggaaagtcaa ggtcggcaaa
     6241 catgcccagc aacgaaggag gaaaaaaagc aatattcacc ttctcgcgcc taatcagttc
     6301 gtctagtaaa gaaatatctc tgcgttcgtc ctcaccggcc aggatcaatg ttcctccggc
     6361 cggaatacac atcatcagtt ctaatatgga agcatcaaaa ctgatactcg caaacgccag
     6421 gtacctgttt gccggatcag acaaatgata caatttctta tctatcagat tcctcgtaaa
     6481 tgtatccaga ttccgataac taatacgtac acctttagga ttgcctgttg ttccggaagt
     6541 atatataata taggcgcaat catcgggaag aacttcagta tagtcaccaa caaccggttc
     6601 ggatagttgc tccccattca ggtaaagttg gcggacggac ggaattccac ctacttcatt
     6661 cgatgaatcg gtcaacaaca aaaccatatc cgcattttca gccatatacc gtttacgatt
     6721 atccggcagc gagggatcta tcggtaaata agttgcccct aaccggaaaa tagccagaat
     6781 ggcaggtact aaagttttgt ttcgttccat acaaactccg atacagatat tccgaagtcc
     6841 ggacggatca gttaccgata aacgttgacg gatagattgt gctatattgg cagagtaacg
     6901 ttccagcatt tgataagaga cggtaccgtc ttttgcaacg accgccggtt tgtcacccca
     6961 ggtagagagt gatcgagaaa gatttttttg aatgtttgtt ttcattatta gtttgattta
     7021 gaaattatac aatatactgg cggaaatcca ccttcctttc tggcggatag gaacagtcgc
     7081 tcctccgcat tcatatcggt tattgaaaag attctcaatg cccagactgc cttctatcct
     7141 tttatactta tatctggtag tgaaagaaaa gacagcataa ccgggcaaac ggactgtgta
     7201 attcgtcgca tctccattga gtccatcttc caatacactt acctgagtgt agcagtggct
     7261 actgcaattc aattttaaat gggcagacca gctctgtact ttctttttaa gtaaaaagta
     7321 gtttgctaca agattcatag aaaagccggg tacgttattc acagatccat cggtaacaaa
     7381 aaaattggta taattcaata ctttctgaaa acacaggttt ccatccaggc tcagtcggtc
     7441 tgccttataa cgggcaacaa cctcgacacc tcccatatcc agagaaccgg cattttcata
     7501 aacacgtgtt tccggctgtg tgaacaggaa atgggacgcc cgattataaa ataaattaca
     7561 ctctacatct atatgtgaag gtgaatgatg ataagcacaa gtcacctgat atgaacttag
     7621 atattcagct tgcagatttt cgccacccga ataggtatcc gtttcattgt ttctgtaata
     7681 atagggcgca tcgacaaatg ctctggaata actggctttg atatttaatc cgttcctgag
     7741 ataaattagt gacagacggg gagaaaaagc ctgtaatgtt cgcttattac ttcgccgttt
     7801 atagtcatac ctgatgccgg cattgacaat ccaattttta tgcaggttgt gtttaatctg
     7861 aagaaaggca tccgtgttca tctcgtgtcc cgtgtaaagt cgtttttcga tccacgtcct
     7921 gacgatctct ttaaaattca taccttccaa atactcggaa tcataaagcg tataccgatt
     7981 ccattccaca ccgccaagca tattgccttt ccccagcttc ccccaatcat aggcatagtt
     8041 tacacgccca ttaaagccta cgttaaaatc catccagcgg atgtattgaa atgctccgcg
     8101 agtcggataa ataataggtt gataatcata gttaggaaaa ataggatagt cttgtaaagt
     8161 atctcccgag gtttcataat gtacgttttt attccaatcg gtataaaatg cggtactgaa
     8221 agtgatccgc tgccacgtgc ggctataaac agcctgttct cttgccgacc acctggaata
     8281 tcccgggccg gaaccgtcaa aagtacgaaa ccgctcataa gaatatggag aagaaaagag
     8341 ccacatgcta taaggttgcc ttttcttcgc gtaattcata ctgaaactaa aaagcaaatt
     8401 tccacgttgc aatttaattc ctccatccat ggcaggaaat cccgaataat tgtccagacg
     8461 gatgaatccg tccctggggt aaagagcata ttgtttttcg gccgggacaa aaaccgattc
     8521 tcccgttgca cggtacaagg agaaccatgc cataaagtcc atgttcatgt cgtgctttcc
     8581 caatagcagg tcagcagcca actggccccg attaccggcg ctgacagata tggaaccatt
     8641 acgaacatcc accccgtctt tagtaactat attaatcacg gctgtcaaag ccacactgcc
     8701 ataaagcgaa gaagccggtc cgcgcagcac ctctatttgt ttgacttttg ccagactaat
     8761 accataatcc ggcgaaacag cattagtaat ataactgttc agacgttgtc catcctgcat
     8821 aatcaatatg ttctcctgtt cgggagaata taccccgcgc atagccagat tcatctcttc
     8881 attggaagac aaaccggata taccgggcac ataagctatc agtacatccc gcaggcaccg
     8941 ggcatggata gcccgtatca tctcctccgt aattaaagta acaggcaccg gagcttcttc
     9001 cggggtctct acctgttgtg aggctgtgac cagagttact ttagtctccc tgtgtttcct
     9061 taccatatcc gcaaagcgtt ccggatcttg aagcgagata taataataag gttcgtcttt
     9121 caataacagc gaaacatact tttccgcttc cgggaagcgg tctaaagcta aacagcataa
     9181 tgcagccaaa cggcacgcct cggtatgcat cgtaccttga aaagacgaca gattctcctc
     9241 caagatacga caagcttcat cgatatctcc gctcttataa aatgtttccg cctttacaaa
     9301 cgaattacgg atgttatccg ccggctgagc tgacagttgc acaaccccaa agcagcaaag
     9361 aatatatagc agacagcgtt tcatgcgata ggaatgataa accggaaaca agtatattca
     9421 tgcaggaccg aatcaaacaa tacttttcca tggtgtttgt tttctataat atcacgaacg
     9481 attgccatac caagtgtccc ctgccccacc ggttttgttg tgaaaaaaga gtcaaatagt
     9541 tttcgtttga cctccggacc catgccctct ccgttatcac gaatagaaag tacaattctt
     9601 ttatccaact tttctaaggt caccattatc tcgggggaat atccttcggg agcattctgc
     9661 cattttttcc atactgcata gcaggcatta ttcatcacat tcaagactgc ccgactgaaa
     9721 tcctgcggga tcagccggat cgaggggata tctttagcat aatcttcacg gatagcaata
     9781 ttgaaattct tataattggc ccgcatggca tgataagcca gccacacata ttctttagtc
     9841 aatttttgta tttgtgtagg catgaattcg tcttctttcc ccctggagta aagcaaaata
     9901 ccacggataa tgctgatagc ccgatcacca tgctctttga ttttgtccac attctctctc
     9961 agcccggaaa gtatatcttt gatatcttcc agttccgctt ccggaatacg agcttttgct
    10021 tcatccaccc tatcggccag gtcggccaac aattgaccgg acagtttact gaaattgatg
    10081 acaaaattca aaggattctg tatctcgtgt gcaatgcctg cactcaacaa acccaatgat
    10141 cccagctttt cctgctcttt gagccgtgct tccaactctt caattcgttt ctcttgtgaa
    10201 atgttttttt ccataatcaa tctgttctat gtttatttat actgactttt cctcccacaa
    10261 tggcagagtg atagtgaatt ctgtcaattc atctttttca gaacgtactg ctatctgccc
    10321 atggtgattt aatatgattt ccttactcag atacaaaccg atacctgctg cctctccggt
    10381 tgttttggta gtaaagaacg gatcgaagat tttatccaga atactctgct cgatccccac
    10441 tccattgtca tataggcgaa tgactgcctg tccgtcctta ctttccaatg ccaggccaat
    10501 ctctgccgga taggctttct taccgtattt tttggctatg gcatacatac cattgttaag
    10561 aagactcata atggtttttc ccagttgttc ggcattcccg tcaataaaca acggattatc
    10621 gggcaaggaa gtacgaaccg caatgtgcat agccgtaatc tccttctgat aataactgct
    10681 caatagctcc atgtctttcc ggcataaacc gattaattct gttttttcca gttgcctgtt
    10741 acggtctctc aggatttctt ccatggcctt cagtacacga gtggtgttac ttccatgttc
    10801 ctcaatcttt tccagattat ctctcatcat gttgatgaca tctaccgaat ccaagtaggt
    10861 atcttcatcc aaaagttctt ttacactctc cagattctga tataggtcct tcagtaatcc
    10921 tgaggtcagg tgggaaaaat tattaatgta attcaacgga ttcagaatac ggtcaatcaa
    10981 cccttgagtc agtttaccta cagtagccat tttttcttgt cgaaccaatt catcttgtgc
    11041 ctggcccagc tccttcaatg ctttttccaa ttttaaggac ttttcctcaa tttcattttt
    11101 ttgttgtacc aactgtttgg tacgttggcc gacaagggcc tctaacctct ccttctcttt
    11161 cagcaaactg cgcattctcc atttaaacaa tacgaacaac agcatcccaa aagcaacggc
    11221 atatagaatc agacaatacc attgcaaata aaaaggaggc aataacgaaa agcggaattg
    11281 tttcatttca ctctctgtac cgtaaatatc acgggcccgg acacaaaacg tatacgtacc
    11341 cgacgaaagg ttggcatact ctttcacagt cccggaatcc cacgaactcc attccggatc
    11401 ataaccgacc aggcgatatc tatactcatt ggaaccggtg aaacagggcg catcggtagc
    11461 aaatgaaaaa cgaatggaac gtacatcatt ccccaaacga ggtactgtac tatttatctg
    11521 ccagtccgct cccccagact cttccggcaa atctcctccc caatagacag aatcacggtt
    11581 cagacaaact tcacgaagat agatgcgggg aacaaccgga gtaaatgtcc gggccttttc
    11641 aaggtccatc cgaattaaac caaaatcacc gccaaaccat gccgccctgt cttcttcaat
    11701 ataaatcacc ctcacgacat aattccgaat ggcatacagg cattggttga atttctccgt
    11761 atcaatttgc gaatgatgta cctgtacctc ttttcctttc agatttgtct gccaatgaca
    11821 gccatcgttg tccgtatact cggtcattat ttcttcactc tctctgtctt gaagtacaaa
    11881 agagcttttg ccctcttccc gcaaatagat ttctccgtac aacgttttag cccatacaga
    11941 acgatctttc ttcacttcca gacgaacgac tttttcgaca tcggaaattt tctttatccg
    12001 ttcctcatct gccgaatatt gataaatccc atccatagtg cccatcagaa ggttcgtatg
    12061 cccaatgaat gccaatgaat aagctgccat atctgtgagt ttttccgaat gattataatc
    12121 ccggatcaca tacacaccat cgccggacgc tgcatataat tctccttgtg gagaaagaca
    12181 cagttgccaa cacgcttgcg aaattccctg aacaggaaca aaagtgtttt gcttcaatac
    12241 gtataatccc tgtaaggtcc cggtatatat cattcctttg taagagacag ccgatattac
    12301 ctctcccttc agaccttcac cagaggtata acggctgaac aaagagggaa taaaaacatg
    12361 aaacacaccg ttatccgtag ctccccagag attgccacgc ccatcggccg caatacccga
    12421 aacagcgtta ctgcataagc catttctctc agttacggaa aaccgttctt ttttcccact
    12481 gtcatccatt attaatccat gggcagagtt tatcgagatt gtttctcctc cgggtagaga
    12541 aaacgcccga ttcattgaga ctgaggattg atttctccac ctttcctgca attgggccgg
    12601 aagtacctga accggtgcca aaatggaatc tgactgaacc gtataatatc ctcctgatgt
    12661 agctttcaga taaatgcgtt tatctatttc tgccatatct tccaattcgc ccaaaaagtt
    12721 tgtgtccaga tcggaaagaa gggttctcaa cgtaatacat ccgcgtccat cacgctctat
    12781 ccgtccgaac acgttatatc ctcccaccca tatcctacct tccgaatcac gaaacaaacg
    12841 ggtgacacgg gaaaagcccg gtgtataaat agtttcccaa cggctatagt cataatgaag
    12901 gataccttcg aaattagcaa aatagacatt tccacaactg tcgcaaacga catcgaaatt
    12961 acgattgtgc gcctgataaa ccgaagccgg atagtttaca aaaaacggga taccttcttg
    13021 tgaatttgca tataccgagc aaagacacat tatcaaagag actatctttt tcatggctga
    13081 tacgttttta ggtaatagga ttcaaatgga atttgcttac cgatataata ctcccattct
    13141 tctcgagtaa aatcacgctg taacccctga cggacaacag cagccatgtg atcgggtgaa
    13201 ataggtaccc gatacaaccg cccctgttcg tctcccataa agac
//
