LOCUS       c00304_gnlPro..        14526 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AFNAMJJP_304.
ACCESSION   c00304_gnlPro..
VERSION     c00304_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 07:55:41
            Original ID  :: gnl|Prokka|AFNAMJJP_304
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14526
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..408
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg304_1"
                     /sec_met_domain="Glyoxalase_4 (E-value: 4.1e-27, bitscore:
                     85.0, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="ELTHIEHLGIAVKSIEACLPYYEGVLGLKCYNIEVVADQKVKTAF
                     FKVGQTKIELLEPTSEDSTIAKFIEKKGEGIHHIAFAVPDVQAALNEAEEKGVKLIDKA
                     PRGGAEGLNIAFLHPKSTCSVLTELCMPGNK"
     protocluster    1..14526
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:4526]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..4526
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14526
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14526
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             445..1998
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg304_2"
                     /sec_met_domain="CT_Btheta (E-value: 1.6e-292, bitscore:
                     960.5, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAML
                     LDEGSFEEFDMFVQHRCTNFGIEKTKYLGDGIVTGYGTIDGRLVYIFAQDFTVFGGALS
                     EALAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVPQI
                     SGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTT
                     KSGVAHFAVDTEEDGLQLIRKLLSFLPQNNLEETPLVECKDPIDRLDDVLNDIIPDNAN
                     QSYDMYEVIGTIVDNNEFLEVHADYAKNIIVGFARFNGQSVGIVANQPKVMAGCLDSNA
                     SRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITV
                     TLRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAAAEDPKACAA
                     EKEAEYKKAFANPYNAAQYGYIDDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
                     "
     CDS             2020..2907
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg304_3"
                     /sec_met_domain="OAD_gamma (E-value: 1.5e-12, bitscore:
                     38.4, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINKKIGVLLLFALLISFGAKAQRATSMRINEVLVINEDNFVDDY
                     GKRHGWIELFNTSAGTVNIAGCYLTDDKNNPMKYPIPKGDVLTQIQPRQHTLFWADGQP
                     GRGTFHVNFVLDPSKENYVALYDADGKTLIDEITIPAGQLADISYGRVIDGEKDWAQLK
                     KVTPSTNNLTLDSNEKIDNFRVNDSLGIGMTITAMAVVFLGLFLLYIIFKQIGKLSIAA
                     SKRNVEKAVGSASVTADAGQESGEIFAAIATALYEMSDDNHDIENTVLTIRKVQRAYSP
                     WSSKLYGLRQTPQK"
     CDS             2930..3361
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 64.8; E-value:
                     1.6e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg304_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 4.9e-21, bitscore:
                     64.8, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFKYTINGNVYKVHINSVVDDIAELEVNGTPYQVKMEKPAKKQ
                     MVTLKRPAQAPTTASGDPVVSRPAASTTQGAVKTPLPGVILQVKCNVGDTVKRGQTLII
                     LEAMKMENNINADRDGKIIEIKVHKGDSVLEGADLVVIG"
     CDS             3366..4526
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg304_5"
                     /sec_met_domain="OAD_beta (E-value: 1.5e-153, bitscore:
                     501.2, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQESFLTFLGENLQLFLTYTGVYNATPGHLIMILVGLLFIFLAIK
                     YEFEPMLLIPIGFGILIGNIPFKDAGLQVGIYEQGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYTIALQMGFEPNQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPIIQPPFMRLLTTKKERLIRMKPPRAVSSTEKIIFP
                     IVGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLAETARGPLIDTITILLGITVGAS
                     TQATQFLTLNSIKIFGLGALSFVIATCAGVLFVKLFNLILKDGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLG"
     CDS             complement(4593..4739)
                     /locus_tag="ctg304_6"
                     /transl_table=11
                     /translation="MRKKSVNTLLVFGVVVAIILLMIWLFLGTTLVEDTSTEISPVPIE
                     QAN"
     CDS             complement(4808..5524)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M22"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg304_7"
                     /sec_met_domain="Peptidase_M22 (E-value: 1.3e-27, bitscore:
                     87.5, seeds: 111, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLILNIETSTSVCSVALSEGEEVVFEKASFEGPSHAALLGVYME
                     EALEVAKSKGMKLDAVAVSSGPGSYTGLRIGVSVAKGLCFGYGIPLIGIHTLDILASAA
                     IRKNKEEADCLYCAMLDARRMEVYSSIYDSHLNTIRATTADIVDADSYASFLENGKVCF
                     FGDGAAKCETVITSPNACFIDGIYPLAVNMASLSQKAYDDARFENVAYFEPFYLKEFQA
                     TIAKNKVLNEALGKNK"
     CDS             5726..6586
                     /locus_tag="ctg304_8"
                     /transl_table=11
                     /translation="MTGFGKVTAELPSKKVTVEIKALNSKQLDLSTRIPSIYKDKEMEL
                     RSLLLQSLERGKVEFNIFIEYIGKDTPTQINLAAVENYYNQIKVIAEKLNISVPNDWFQ
                     TLLRMPDAIKSETVEPDESEWEVVLETVKDAIKHLCDFRIQEGAMLQKLFEQKIANIAT
                     LLKEVEKYEGERIEKIKARIMDNLQKIAEKDYDKNRFEQEMIYYIEKLDVNEEKNRLDN
                     HLKYFISTMESGHGQGKKLGFIAQEMGREINTLGSKSNHAEMQKIVVQMKDELEQIKEQ
                     VLNVL"
     CDS             6601..7167
                     /locus_tag="ctg304_9"
                     /transl_table=11
                     /translation="MAGKLIIFSAPSGSGKSTIINYLLKQDLHLRFSISATSRAPRGTE
                     KNGVEYYFLTPEEFRSRIANGDFLEYEEVYTDKYYGTLKSEVERILNEGDNVIFDVDVV
                     GGCNIKKFYGDRALSVFIQPPCIDDLRKRLEGRGTDSPEVIESRIAKAEYELGFTGQFD
                     KVVVNDDLETAQKDALKIIREFLNK"
     CDS             7171..7350
                     /locus_tag="ctg304_10"
                     /transl_table=11
                     /translation="MPNIFKNTRFMMGLSIVCGIASLVLGGISLYYKEYIIGGALIFNI
                     FICFINYKGWQKKG"
     CDS             7362..7937
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CTP_transf_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg304_11"
                     /sec_met_domain="CTP_transf_like (E-value: 5.9e-26,
                     bitscore: 81.7, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLKTGIYSGSFNPIHIGHLALANWLCEFEGLDEVWFVVTPHNPL
                     KKKDDLLDDSLRLEMAQAAIDGYPKFKVCDIEFHLPKPSYSIDTLRALSSNYPDRDFYF
                     IMGADNWLLFPRWKEYEKILQNYKLLIYPRLGFDISIPTIYPNVKKVDAPLMEISSTFI
                     RNAYQTGKDIRFFLPEGVRPYFGSVANQ"
     CDS             8786..9901
                     /locus_tag="ctg304_12"
                     /transl_table=11
                     /translation="MIYLLFLVTLLLISCNPDQAKDNGKDETIEYFIPLSHRVEKDVDE
                     MFEEYRYVPLETRDDALIDVLYNVKNIAIFQEDIYIGSGEQLIVWDKYGKFKRVLSKKG
                     NDPQSYLHFNHFMIWPNGDLSIASPIEIVTYSNSHQFINKKRCENVGYIEAITLLNDSL
                     YIIKCMPTPEQLRYRIINHHTGAIINSYDSIINCNRYISSFTNSFERYEGHIISHGYQS
                     NDILECTLDSSKIRYKINVDNRIPPAGFYTQEGKEGMQLIQEEAEKGYIGHIPDYVESK
                     ETILLSFKGKREDLNGIALIDKKDGNARVLENIKFDDNFRWLPKQFFSLDEGWCAMLMY
                     PEDVLKKEEFARRFPGLDEESNPVLFIGKLR"
     CDS             9921..11468
                     /locus_tag="ctg304_13"
                     /transl_table=11
                     /translation="MEHDNLFIQILEILSIKHTEDFTIRYYERHPHKNNLFGLSEMLRY
                     YNIENVAAEIQKTQENLSSLDVPFVAYVDHEFVSVRHVSTEAIIYSWRGKNITLSIPVF
                     LERWSGIVLLFESTDESIEPDYKEHRKEYLRQRIVIACFVSLLLSLIGCALITNRGMEI
                     GIWGLWGVNVIGASFCGILLSREILGSDKYVNKICSLFLKSSDCNGTLDSQASHFLGIS
                     WSVFGLGYFLSAILFIALLPQYVIYAETLNIIALPYTAWSVWYQKFRVKQWCALCLSVQ
                     ATVWITFLISLFAIGMDFNQWDLFDFTTIGCVYGLVILSLHFTVTLYVKEKQIQRSNNK
                     LSSIKLNASVFKSLLNEQPQYDIDKNTGILLGNRDAKEWITIISNPHCAPCAKLHLQIE
                     KLLKEYKEEICIQIILTSFSKELEPSAMLLTSMYLLNNESDYLRFLSDWYAKGRHKKED
                     CYKRYRLNPNDKDMLANFQAQNEWVRRNTISSTPTVLTNGYLLPEEYELKDISYLIN"
     CDS             11474..12517
                     /locus_tag="ctg304_14"
                     /transl_table=11
                     /translation="MNKLASQIDSLNKHLIGSLHTSYPFGLAHGKMGLLIYLYHLYDYT
                     QEAIYKEKAERLLDDLLENDLSKNAELTVEEGLCGVALGLDYIVKKQFVDGDINDLLSG
                     IDDLLFKKLVFGNMESRYSLSQLIHFLYYIYKRLEIQTNDNERFPFEGLAIKLVNQLAD
                     LIDASFFEESYTFSIYQYHVPILMKTLSYLIQYDFYKDRIQKVLEQLSLYMFSHLPHLH
                     LNRLYLLWGILPLRNCSPDWQRYVNELRKSINLDIIYNREIKGKDIYISNGYASLYFLL
                     EGLKRDFPEYTIPFNPHLIYDRIISSDAWDALMENEYYYNIHRGLLNGFPGTVLALLNI
                     KQRYLCE"
     CDS             12508..13197
                     /locus_tag="ctg304_15"
                     /transl_table=11
                     /translation="MRIDLTDTTFIIPVRIDSMIRLENLLMSVDSIVRYFRTRILIMEA
                     SSYQNEIIPSLIKDDTVKYTFLVDKDPVFYKTKYLNILAKQVDTPLVCIWDADVILDHL
                     QILDAVKQLRTRTSDVAYPYDGNFLDTSDILREHYWLHRDLDFLKKHQAKMNSLYTVEG
                     VIGAVGGAVFAQTEKYLQAGMENEDFYGWGLEDGERHYRWLSFGYRIYRSEGCLFHLSH
                     PRDQNGM"
ORIGIN
        1 gaacttacac atatcgaaca tttaggtatc gcagtgaaga gtatcgaggc ttgtttaccc
       61 tattatgaag gcgttcttgg attaaaatgc tacaatatcg aagtagtagc agaccaaaaa
      121 gtaaaaaccg catttttcaa ggtaggacag actaagattg aactactaga gccgaccagc
      181 gaagatagca cgatcgcgaa atttatcgag aaaaaaggtg aaggtatcca ccatatcgca
      241 ttcgcggtac ctgatgtaca ggcagctttg aacgaggctg aggaaaaagg cgttaaatta
      301 atcgataaag ctcctcgtgg tggcgcggaa ggcttgaaca tcgctttcct tcacccgaaa
      361 tcaacttgca gcgtattgac agaactttgc atgccgggca acaaataatt aatccgttca
      421 tttctaacaa caaatcaaaa tacaatgagt aaccagcttg aaaaagtaaa agagctcatc
      481 gcacttcgtg agcaagctcg cttgggtgga ggagagaaaa gaatcgaatc acagcacaaa
      541 aaaggcaaat ataccgctcg tgagcgtatc gccatgttgc ttgacgaagg tagtttcgag
      601 gaattcgaca tgtttgttca acaccgttgt acaaacttcg gtatcgagaa aactaaatat
      661 ttaggcgatg gtatcgtaac aggttatggt acgatcgacg gacgtttggt atatatcttc
      721 gctcaagatt tcaccgtatt cggtggagcc ttgtctgagg ctttggctat gaagatctgt
      781 aaagtaatgg atcaagccat gaagatgggc gctcccgtta tcggtttgaa cgactccggc
      841 ggagctcgta tccaagaagg tgtaaacgcc ttggcaggat atgcggagat tttccaacgt
      901 aacatcttag catctggtgt tgttccccag atttccggta tcttcggccc ttgcgccggt
      961 ggagccgttt attctccggc tttgacagac ttcaacatca tgacacgtgg taccagctac
     1021 atgttcttga caggtccgaa agtagtaaaa accgtaacag gtgaggatgt aacccaagag
     1081 cagttgggtg gagccagcgt acacactaca aaatcaggtg tagcccattt cgctgttgat
     1141 acagaagagg atggtttgca attgattcgt aaattgctca gtttcttacc tcagaacaac
     1201 ttagaggaaa cgccgttagt tgagtgtaaa gacccgatcg atcgtctgga tgatgtattg
     1261 aacgatatca ttcccgataa cgctaaccaa tcttacgata tgtatgaggt tatcggtacg
     1321 atcgtcgata acaacgagtt cctagaggtc catgcggact acgctaagaa tatcatcgta
     1381 ggtttcgctc gtttcaacgg acaatctgtc ggtatcgtag ccaaccagcc gaaggttatg
     1441 gcaggatgct tggatagcaa cgcatctcgt aaagcaggtc gcttcgttcg tttctgcgac
     1501 gctttcaata ttcctttggt aacattggtt gacgttccgg gattccttcc gggtacaggt
     1561 caggaataca acggtgtaat ccttcatggc gctaaattgc tttacgctta tggtgaggct
     1621 accgttccta agattaccgt tacattgcgt aagtcttacg gtggagctta ttgcgtgatg
     1681 agttctaaac atttacgtgg tgatatgaat tacgcatggc cgacagccga gatcgccgtt
     1741 atgggcccga gcggtgccgt agaggttatc ttcgccaagg aagtagcagc cgctgaagat
     1801 ccgaaagcat gcgcagcaga gaaagaagct gaatataaga aagcattcgc taatccttat
     1861 aacgcagctc aatacggtta tatcgacgat gttatcgaac cgcgtaacac tcgtttccgt
     1921 ataattcgtg ctttgcagca attgcagact aagaagctaa gcaatcctgc taagaaacat
     1981 gataacctgc ctctataatc cgtaaaacag gagatgaata tgataaataa gaaaataggg
     2041 gtattgctat tgttcgcttt gctcatttca ttcggggcaa aggcacagcg cgcaacctcc
     2101 atgcgaatta atgaagtatt ggttatcaac gaggataact tcgttgatga ctatggcaaa
     2161 cgtcatggct ggattgagtt gttcaacact tcggccggaa cggtaaatat cgcgggatgc
     2221 tatttgacag acgacaaaaa caatcccatg aaatatccga tcccgaaggg agacgtatta
     2281 actcagatcc aaccccgcca gcacacacta ttttgggctg acggacagcc gggcagaggt
     2341 acattccacg ttaacttcgt attagatccc tctaaggaga attatgttgc cttatatgac
     2401 gccgacggta agaccttgat cgatgagatc acaattccgg caggccaatt agcagacatt
     2461 agctacggta gagtgattga tggcgaaaaa gactgggcac agttaaagaa agtcactccc
     2521 agtacgaaca acttgacgtt ggactccaat gagaaaatcg ataacttcag ggttaatgac
     2581 tctttaggta tcggtatgac tatcacggct atggctgttg tattcttagg tctgttcttg
     2641 ttgtacatca tctttaagca gattggtaaa ttatctatcg ccgctagcaa acgtaacgta
     2701 gagaaggccg taggttctgc ttcagttacc gcagacgcag gacaagaatc tggagagata
     2761 ttcgccgcca tcgctaccgc tctatacgaa atgagcgatg ataatcacga tatcgagaac
     2821 acggttctca ctatacgtaa ggtacaacga gcttattctc cttggagttc aaaactctat
     2881 ggcttacgtc aaactcctca aaagtaatta tctaaaaacg aactaaagaa tgaaaagttt
     2941 taaatatacc attaacggta acgtatataa agtacacatc aattctgtag tggatgatat
     3001 cgcagaactt gaagtaaacg gaactcccta ccaagttaag atggagaaac cggcaaagaa
     3061 acaaatggtt acattgaaac gcccagctca agccccgact acggcaagtg gagaccctgt
     3121 tgtttcccgt ccggcggctt ctacgacaca aggggctgtt aagactccgc taccaggtgt
     3181 tatcttgcag gttaagtgca acgtaggtga taccgtgaag agaggtcaaa ccttgattat
     3241 ccttgaggct atgaagatgg agaacaacat caacgcagac cgtgacggta agattataga
     3301 aattaaagta cacaagggag actctgtgct agaaggtgct gatctcgtag taatcggata
     3361 agactatgca agagagcttt ttaacattct taggtgagaa cttacaactg ttccttacct
     3421 atacaggtgt atacaacgct actccgggac atctcatcat gattctggta ggtctgttgt
     3481 ttatattcct ggcgattaaa tatgagtttg aaccgatgct tttgatccct atcggattcg
     3541 gtatcttgat cggtaatatc cctttcaagg acgcaggtct tcaagtaggt atttatgagc
     3601 aagggtctgt actgaacatc ctctatcagg gtgtgacctc tggatggtat ccgccattga
     3661 tcttcctcgg catcggggcc atgaccgact tctccgcatt gatctccaat ccaaagttga
     3721 tgttgatcgg tgcagcggct cagttcggta tctttggtgc ttatacgatt gctcttcaaa
     3781 tgggatttga gccgaaccaa gcaggtgcta tcggtattat cggtggtgct gacggtccga
     3841 cggctatctt cctttcttct aagttagcgc caaacttaat gggtgcgatt gcggtatccg
     3901 cctactcata catggcgttg gttcctatta tccaaccacc gttcatgaga ttgcttacga
     3961 ctaagaaaga gcgtttgatc cgtatgaaac cgccgagagc cgtttcttcc acggaaaaaa
     4021 ttatcttccc gatcgttggc ttgttgctta cttgcttctt ggttccgtcc ggtttaccat
     4081 tgttaggtat gctattcttc ggaaacttat tgaaagaaag tggcgtgact cgtcgtttgg
     4141 cagagactgc tcgtggtcct ctgatcgata caatcacgat cttattgggt atcacggtag
     4201 gtgcttctac tcaagcaact cagttcttga cattgaactc tatcaagatc ttcggtctag
     4261 gtgcgttatc attcgtgatc gctacttgcg ccggtgtatt gttcgttaaa ttattcaatt
     4321 taatattgaa agacggcaat aagatcaatc cgcttatcgg taacgccggt gtatctgctg
     4381 ttcccgactc agctcgtatc tctcaagtcg taggtttgga atacgacccg accaattact
     4441 tgttgatgca cgctatgggt ccgaacgtag caggtgtaat cggttccgct gtagctgccg
     4501 gtatcttgct aggattcctt ggttaataaa acaactatct atattaaaaa aggcgaggtc
     4561 cgaaaggatc ccgccttttt atgttattgt tctcagttag cttgctctat aggaaccgga
     4621 ctaatctccg tactcgtatc ctccaccaac gttgtcccga ggaacaacca gatcatcaaa
     4681 aggattatag cgacaaccac accaaacacc aatagcgtat tcacactttt ctttctcatg
     4741 tctttaactg atttattcat tttagaataa acagccggaa catgaatttg gttgtgtacc
     4801 cttactctta tttgtttttc cctaacgcct cgttcagcac tttgttctta gcgatcgttg
     4861 cttggaattc tttcaaatag aaaggctcaa aataagccac attctcaaaa cgggcatcat
     4921 catatgcttt ctgcgacaag gatgccatat ttacagctaa tggatagata ccatctataa
     4981 aacaggcatt cggggaagtg attaccgtct cacatttagc ggcaccgtct ccaaagaaac
     5041 aaaccttacc gttctctaaa aaagaagcat acgaatcagc atctacgata tcagcagtcg
     5101 tagcacgtat cgtgttgaga tgggaatcat aaatcgaaga gtagacttcc atacgacggg
     5161 catccaacat agcgcaatac aagcaatcgg cctcctcctt atttttccgg atagcggcag
     5221 acgctaaaat atccagcgta tgaataccga tcaaaggaat accgtaccca aagcataatc
     5281 ctttagccac agacaccccg atgcgtaacc ccgtataaga tccgggtccg ctacttaccg
     5341 ccacggcatc cagtttcatc cctttcgact tcgcaacctc taatgcctct tccatataaa
     5401 cgcccaataa cgccgcatga gacggcccct cgaaggaagc cttctcaaag accacctcct
     5461 ccccttccga cagggctact gaacatacgg aagtggatgt ctcgatattt aagatcaatg
     5521 acataataat taactattaa caattgataa ttgaacgaac aaacaatctc aatccttcaa
     5581 tctgattagg ctgcgaaggt atacaaaaat tcattatact atcaaggcag ccctatgaga
     5641 aacatctatt tatgagaaaa taaacatcaa atctaaaagg aaaccactat ctttgcgcaa
     5701 acttttgaga aaaatgatac aatcaatgac tgggttcggt aaggttactg ccgagctccc
     5761 ttcaaaaaaa gtaaccgtag agataaaggc tttaaacagt aagcaattgg atttgtccac
     5821 ccgtatccct tctatataca aggataagga aatggagctt cggagcctgt tacttcaatc
     5881 tttggagcgg ggaaaagttg agttcaatat ctttatagaa tatataggca aagatactcc
     5941 tacacagatc aatcttgccg ccgtagagaa ttattacaac caaatcaagg tgatcgcaga
     6001 gaaactgaat atcagcgttc cgaacgattg gttccagacc ttgctccgga tgccggacgc
     6061 aatcaagtcc gaaaccgtag aaccggacga atccgaatgg gaggtggttt tagaaacggt
     6121 aaaggacgct atcaagcacc tgtgtgattt ccgtatccaa gaaggagcca tgcttcaaaa
     6181 gcttttcgag caaaagatag ccaatatcgc cactctgttg aaagaagtgg agaaatacga
     6241 gggggaacgt atcgagaaga tcaaggctcg tatcatggat aacctgcaaa agatagccga
     6301 gaaggactac gacaagaatc gtttcgagca ggagatgatc tattacatcg aaaagctgga
     6361 tgtcaacgag gaaaagaacc gtttggacaa ccacttgaaa tattttatct caaccatgga
     6421 atccggtcac ggccaaggta agaagctcgg ttttatcgct caggaaatgg gacgtgagat
     6481 caatacgctc ggatcaaaga gcaaccacgc cgagatgcag aagatcgtgg tccagatgaa
     6541 agacgagttg gaacaaatca aggaacaggt actaaacgta ttataataag attaacgaga
     6601 atggctggca aattaattat cttctccgca ccctcgggtt ccggaaaatc aaccattatt
     6661 aattatcttt tgaaacaaga tttacacctt cgtttctcca tctcggctac cagccgggct
     6721 ccgcggggaa ccgagaagaa tggtgtggaa tattatttcc ttacgccgga agagttccgc
     6781 agtcgtatcg ctaatggaga cttcttggaa tatgaggagg tgtataccga taaatattac
     6841 ggtacgttaa agagcgaggt agagcgtatc ttgaatgaag gggacaacgt gattttcgat
     6901 gtggatgtgg taggcggatg caatatcaag aaattctatg gagaccgtgc cctgtctgtc
     6961 tttatccaac ctccttgcat cgatgaccta cggaagcgat tggaaggacg gggaacagac
     7021 agcccggaag ttatcgaaag ccgtatcgcc aaggcagagt atgaattagg gttcacggga
     7081 cagtttgata aggttgtcgt aaacgatgat ctggagactg cccaaaaaga tgcgttgaag
     7141 atcattcgtg agttcttaaa caaatagtct atgcctaata tattcaagaa tacccgtttt
     7201 atgatggggc tttctatcgt ttgtgggata gcgagcctcg tattaggtgg tatcagcctg
     7261 tattataagg agtatatcat cgggggtgcc ctgatattta atatattcat ttgttttatc
     7321 aactataagg gttggcaaaa gaaggggtaa gtataaatcg gatgagactc aagaccggca
     7381 tctacagtgg atcgttcaat cccattcaca taggccatct cgccttggcg aactggctat
     7441 gtgagttcga gggactggat gaggtgtggt tcgtggtcac gcctcataat ccgctgaaga
     7501 aaaaggatga cttgctagat gactcactac ggttggaaat ggcccaagcc gccattgacg
     7561 gatatccgaa attcaaggtc tgcgatattg agttccacct gccgaaacct tcttattcca
     7621 ttgataccct acgagcctta tccagtaact atccggatag ggacttttat tttatcatgg
     7681 gagccgataa ctggctgctt tttccccgat ggaaagaata tgaaaaaata ctccaaaact
     7741 acaaactgct gatttatccc cgcctaggat tcgatatctc gatcccaacc atttatccga
     7801 acgtgaaaaa ggtagacgct cccttgatgg aaatctcctc cacatttatc cgtaacgctt
     7861 accaaaccgg caaggatatc cgtttcttcc taccggaagg agtgcggcct tatttcgggt
     7921 cagtagcaaa tcagtgacat acctgcgata gaagatatac ttacttgggc tatgaagtat
     7981 atatcctatg ccacttgaag tatatattct tcgagaaggg aagttatacc gtgattattt
     8041 acagctttgc catcttaggg caatctgcca aaattcccat taaaacatgt tttacagcac
     8101 agccgttaaa gatgatcccc gtaacatcaa aacaggctca cccgataatc tttttggagt
     8161 atccaaatat ataatttgag ccttgtcaag tgattagtta ttcatttggg aggctttgta
     8221 cctatagctt acgctattac ataaaacact attacataac aaattacatc aatacaataa
     8281 gtcatttctc gaacaaatta aacgtgggac agaacaatcg aattcgcata gctaacttat
     8341 atgcatatct ccactaattt tctactgtag caatagaaag acaatataca ttaaacaaca
     8401 ataaaaaaga cataatatac cccatgtttg atatttttta attttctttg taatatcaaa
     8461 gtattacaca tctattaact ttttaaatcc ttcaaattat ggacaaactc aaaaaaactg
     8521 acaaaagtcg tactaaacca acaaagtaaa gttcttccaa aagaacaaat gatgaaaatc
     8581 ttagggggag gaagtgcgta ttgtcattgt cataatcttt cttcctcaat tgaagtaaca
     8641 agctgctctg aatgcagtaa taaatgctca aattatggcg gcgtacaaaa ctgtaacact
     8701 acaggaggtt agcaacaaaa gaaagggctg gttttagctg gtgatatctg ctaaaaccag
     8761 cttttttctt aaaacaaaaa tgaccatgat ctatcttcta tttttagtca ctcttttgct
     8821 tatcagttgt aatccggatc aagccaagga taatggcaag gacgaaacaa tcgagtattt
     8881 tattccactc tcacatcggg tagaaaaaga cgtggatgaa atgtttgagg aatatcggta
     8941 tgtccccttg gaaacaaggg atgacgcatt gatagatgtg ctttacaatg ttaaaaacat
     9001 cgctatcttt caagaggata tttacatagg ctccggagag caattaatcg tttgggataa
     9061 atatggaaaa ttcaaacgag tcttatccaa aaagggaaat gatccgcaat catacctcca
     9121 ctttaaccat ttcatgatat ggcccaatgg agatctatcg atcgcttctc ccattgaaat
     9181 cgtaacctat tcaaattcac accaattcat caacaaaaag cgttgcgaga atgtcggcta
     9241 tatagaggcg atcactcttt tgaacgatag tctatacatc ataaaatgta tgcctacccc
     9301 cgaacagcta cgataccgta tcatcaacca tcatacggga gccattataa actcgtatga
     9361 ttccatcatc aactgcaatc gatatatcag ttcattcaca aactcatttg aacggtatga
     9421 aggacatatt atctctcatg gttatcaaag caacgacatc cttgaatgca ctttggatag
     9481 ttcaaaaata cgatacaaaa taaacgtaga taacaggata ccgcccgccg gcttttacac
     9541 gcaagaggga aaagaaggca tgcaactcat acaggaagaa gcggagaaag gatacatcgg
     9601 ccatatcccg gactacgtgg agtccaagga aacgatattg ctctccttta aggggaaaag
     9661 agaagaccta aacggaatag ccttaatcga caaaaaagac ggaaacgcaa gagttttaga
     9721 gaacatcaag ttcgatgaca acttccggtg gttgcccaaa cagttcttct cgttagatga
     9781 gggctggtgc gccatgctga tgtatccgga agacgttttg aagaaggaag agttcgcaag
     9841 gcgtttcccc ggactggacg aggagagtaa cccggtgttg ttcattggta aactaaggta
     9901 atcattaaag acctaaagca atggaacatg acaatctatt catccaaatt ttagaaatct
     9961 tatcgataaa gcacacggaa gattttacca taagatacta cgagaggcat ccacacaaaa
    10021 acaatctgtt tggactgtcc gagatgctac gttattataa tatagagaat gtagcggccg
    10081 aaattcaaaa aacacaagaa aacttatcct cattggatgt accctttgtg gcttacgtag
    10141 atcatgagtt tgtatcggtg cgacatgttt ctaccgaggc aatcatctat tcatggcgag
    10201 gtaaaaacat cacattatct atcccggtat tcttggaacg atggtcagga atcgtccttc
    10261 ttttcgaatc caccgatgaa tctattgaac cggattataa agagcataga aaggaatact
    10321 tacgacagcg gatagtaatc gcatgtttcg tttcattact tctatcatta atagggtgtg
    10381 cccttatcac caacagagga atggagatag gaatctgggg gttatggggt gttaatgtga
    10441 tcggagcatc tttctgcggt atcctgcttt ctcgagagat cttaggctcg gataaatatg
    10501 tcaacaaaat ttgttccctg tttttgaaat ccagtgattg caacgggaca ttggattccc
    10561 aagcatctca tttcttgggg atcagttgga gtgtcttcgg cttaggatat tttctttccg
    10621 caatattgtt tatcgccttg ttgccccaat atgttatata tgcagagact ctgaatataa
    10681 tcgcattacc ttatacagcg tggagcgtat ggtaccaaaa atttagggta aaacaatggt
    10741 gcgctttatg tttatctgta caagctaccg tatggatcac ctttcttatc tctctattcg
    10801 cgataggcat ggatttcaat caatgggatt tatttgattt cactaccatt ggatgcgtgt
    10861 atgggctcgt cattctatcg ctccatttta ctgttacatt atacgtaaaa gaaaagcaaa
    10921 tccaacgaag caacaataaa cttagcagca taaaactgaa tgcctctgta tttaagagct
    10981 tattaaacga acagcctcaa tatgacattg acaaaaatac aggaatatta ttgggcaata
    11041 gggatgccaa agagtggatt accattatct ctaatccaca ttgtgctcct tgcgcaaaat
    11101 tacatctcca aatagaaaag ttactcaaag aatataaaga agagatttgc atacaaatca
    11161 tcttgacctc ttttagcaag gaattagaac ctagcgccat gctactgacc tccatgtatc
    11221 tactaaataa tgaatcggat tatttacgat tcctatctga ctggtatgca aaagggcgtc
    11281 ataaaaaaga ggattgctat aaaagataca gattaaatcc taatgacaaa gatatgttag
    11341 ccaattttca agcacaaaac gaatgggtta ggcgcaatac aataagttcc actccaacag
    11401 ttttgacaaa tggttattta ttgccggaag aatatgagtt aaaggatata tcgtatttaa
    11461 taaattaagt actatgaata aattagcatc acaaatagat tcgctaaata agcatttgat
    11521 aggctcatta catacaagct accctttcgg gttggctcat ggcaaaatgg gattactcat
    11581 ctatttatac catttgtatg attatacgca agaagctatt tataaagaga aggctgagcg
    11641 attgctggac gatctcttgg aaaacgatct ctctaaaaac gcagaactca ccgtggagga
    11701 aggtttatgc ggagttgcgt taggattgga ttatattgta aaaaagcaat ttgtagacgg
    11761 tgatattaat gatttgctaa gtggtatcga tgatttgcta ttcaagaagc tggttttcgg
    11821 aaatatggaa tctaggtatt ccctgtctca actcatccat ttcttatatt acatttataa
    11881 aaggctggaa atccagacaa acgataatga gcgtttccct ttcgagggct tagcaatcaa
    11941 gttagttaat caattggccg atttgataga cgcctccttt ttcgaggaat cctatacgtt
    12001 ttccatttac caatatcacg taccgatatt gatgaaaacc ctgtcctatc ttatacaata
    12061 tgatttttac aaggatcgga tacaaaaggt tttggaacaa ctatctctgt atatgttctc
    12121 ccatttgcct catctgcatt tgaaccgact atatctgtta tggggcatac tacctttacg
    12181 gaattgttcg ccggattggc aaagatatgt gaacgaacta agaaaatcaa tcaatctaga
    12241 cataatatat aatagagaga tcaaaggcaa ggatatctat atcagtaatg gatacgcttc
    12301 tctatatttc ttgttggagg gattaaaaag ggacttcccc gaatacacca tccctttcaa
    12361 tccgcaccta atttacgatc ggatcatctc gtctgacgct tgggatgccc taatggagaa
    12421 cgaatactac tataatatac acagaggatt gctgaatggt ttccccggta cggtgttggc
    12481 attgttaaac attaagcaaa gatatttatg cgaatagact tgacagatac aacatttatt
    12541 attcctgtac ggatcgattc catgatccgt ttggagaacc tgttgatgtc cgtggactca
    12601 atagtacgtt atttccggac acgcatctta attatggagg cctcatcata ccaaaatgag
    12661 attatcccct cgttaataaa agatgatacg gtgaagtaca ctttcctcgt ggataaagat
    12721 cctgtattct acaagaccaa atacttgaat atcctcgcaa agcaggttga tactccactt
    12781 gtttgtattt gggacgcaga tgtgatactg gaccaccttc aaatattgga tgcggtgaaa
    12841 cagcttagaa ctaggacttc tgatgtcgct tatccatatg atggtaattt tttagatacg
    12901 tcagatatat tgagggaaca ttattggctc catcgtgact tagatttcct aaaaaaacat
    12961 caagcaaaga tgaactcttt gtacacagta gagggagtga taggcgcagt cgggggagcg
    13021 gtcttcgccc aaacggaaaa atacctgcaa gcgggtatgg agaatgagga tttctatggc
    13081 tggggcttgg aggacggaga aagacattac cgttggttga gttttggcta ccggatttat
    13141 cggagtgagg gctgtttatt ccatttgtct catccccggg atcaaaacgg gatgtaaaga
    13201 taaaattatt gggtcttaag ttcattggcc tacaaaccta agatacttca ccaaggatcc
    13261 taagatactt taccgatgaa cctaagatac tttatccatg aactaacaag atcggtgacc
    13321 tcaacctttt accacataag tcagcataaa tcagaaatat tttgtacttt tgcgccgtat
    13381 tatacaaaat aatagcataa tgaatctatt agaactgagt gaacaggaaa taataagacg
    13441 taatagcatg gagcagttgc gtcagatggg gatagagcct tatcccgcag ctgagtatgt
    13501 aacgaacgca ttttccaaag agataaaaga gacattcaaa gatgacgctg agccacgccc
    13561 ggtacgtatc gccggccgta tcatgagccg tcgtatcatg ggaaaagcct ctttcatgga
    13621 gttgcaggat tccgagggca gaatacaggt ctatatctct cgtgacgata tttgtccgga
    13681 cgagaataaa gacacataca atgtcgtttt caagaaatta ctggatatcg gtgatttcgt
    13741 cgggatcaag ggattcgttt tccgtactca aatgggagag atttccgttc atgcgcaaga
    13801 attgacagtt ctgtctaaat cacttcgtcc gctaccggtc gttaaatata aggatggtgt
    13861 cgcttacgac ggttttaatg acccggagct tcgttatcgc cagcgttacg tggatttggt
    13921 agtaaacgag ggtgtaaaag atattttcat gaaacgtgcg gctatcatca agaccatgcg
    13981 taccgccttg gatgaggccg gatacacgga ggtagagact ccgatcctgc aatctatcgc
    14041 aggaggagcc agcgcacgtc cattcatcac gcatcacaac tctttggata tcgatctgta
    14101 tttgcgtatc gctaccgagt tgtatttgaa acgattgatc gtcggtggat tcgagggtgt
    14161 atatgagatc ggtaagaatt tccgtaacga gggtatggac cgtacgcaca acccggagtt
    14221 cacttgtatg gaactttatg tccaatacaa ggactataac tggatgatga gcttcactga
    14281 gaagctgttg gagcgtatct gtatcgccgt gaacggtacg agcgagagca cgatcgacgg
    14341 taagacaatc agcttcaagg ctcctttccg ccgtttgccg atcttggagg cgatcaagga
    14401 aaagacgggt tacgacttgg aaggtaagag cgaggacgag atccgtacga tctgcaagga
    14461 attgaagatg gagatcgacg atacgatggg taaaggtaaa ttgatcgacg agatcttcgg
    14521 ggagtt
//
