LOCUS       c00458_gnlPro..        13761 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AFNAMJJP_458.
ACCESSION   c00458_gnlPro..
VERSION     c00458_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 07:55:41
            Original ID  :: gnl|Prokka|AFNAMJJP_458
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13761
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13761
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2913:7771]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2914..7771
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..13761
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13761
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             3..1859
                     /locus_tag="ctg458_1"
                     /transl_table=11
                     /translation="YEKETYRQQSERTGLRKRVAQGLCWYPVTPGRSYYNSLNQLVIEI
                     ERTEDREIEHNFEYGRPVCFFTADISGKFKYLDFSATISYVQEDRMVVVLPTPSALMDI
                     QGKSNDLGVQLYFDETSYKTMFSALSDVMRAKNNQLSHLRDVLLGQEKPGQRELFPIRF
                     PWLNRSQEEAVNKVLGAKQVSIVHGPPGTGKTTTLVEAIYETLHRENQVIVCAQSNTAV
                     DCISEKLVDRGINVLRIGNPTRINDKMLSFTYERRFESHPDYPELWSIRKAIRDIQSNM
                     RKKSREERDTIRNRLSRLKFRATELEVKIDTELFDEARVVACTLVGSANRVMMNRHFTT
                     LFIDEAAQALEAACWIAIGKADRVILAGDHHQLPPTIKCIEAEREGLGRTLMQKIAHTK
                     PETVSLLKIQYRMHEDIMRFSSQWFYHNELESAPEVSGRGILRLDTPIVWFDTSECDFT
                     ENTREETMSRVNRQEAELLVEQLRSYIQKISKERVLEENIDFGLISPYKAQVQYIRKLI
                     KQDAFFKPLRRLITVHTVDGFQGQERDVILISLVRANEDGKIGFLNDLRRMNVAITRAR
                     MKLMILGDASTLTRHAFYKELYNYISQRGKIITINTKQEHEL"
     CDS             1849..2655
                     /locus_tag="ctg458_2"
                     /transl_table=11
                     /translation="MNYKLLVLDLDGTLTNSKKEITPFTRETLLQAQEKGLHLVLASGR
                     PTYGIVPLAEELNIKQYGGFILSFNGGKVIDLMTDKVLFEQALPPDIVPVLYNRSKEAG
                     LAILSYNGKYILSEHPENKYVQYESFLTKMKIKATDDFLRDLHQPADKCLVVGEPEMLV
                     PLEEKLRQELGKRINVYRSEAFYLELVPKGIDKAASLSRLLERTRIKQEEVIAIGDGFN
                     DVSMIRFAGLGVAMANAQPPVKANADRITQYTNDEDGVARFIQELL"
     CDS             2914..4146
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg458_3"
                     /sec_met_domain="HBT (E-value: 1.6e-17, bitscore: 53.4,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDKKEITPRTHAALLKAQQMGVHVVLASGR
                     PTNGVQPLAEALELNHYGGFILSYNGGQIINAQTGELMFEKRIDPAMIPYLNRKAKENG
                     FAIFTYHKDYILTDSPENKHVQEEAELNKMRIIGVENFPEAVDFAPCKCILTSDDENNL
                     VGLENHWKKRLDGVLEAFRSEDYFLEVAPHFINKGNTLAVLMEMLNITTEEVVAIGDGV
                     ADVSMLQLAGTGVAMGNARDSVKACADFTTLSNNMDGVAVAIEKAILATIKPTEVPLDQ
                     LNARAKHALMGNLGIQYTYASEDRVEATMPVDERTRQPFGILHGGATLALAETVAGLGS
                     MILAKPDEMVVGMQVSGSHMSSAHEGDTVRAVGTIIHKGRSSHVWNVDIFTSTDKLVSS
                     VRVINSILKKK"
     CDS             4143..5240
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg458_4"
                     /sec_met_domain="Chorismate_bind (E-value: 1.3e-54,
                     bitscore: 175.0, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPRDSYEIIDTLIKQGRSFAIWRIPGEDRLHFRMQSAGSPCLLY
                     DIKDLNERSGFVIAPFQVTAERPIVLIQPDCFEIPSESDWDFSREKNEFPSNEIEIPSE
                     SEEKERYAYHFSLFTSPLLKGSQDKLVLSRSKTIRKDPSFSPGKAFFAAVERYIRSYVY
                     LCHTPETGTWMGGTPEILLSGEKGDWQTVALAGTQSLRDGKLPKSWDHKNWREQQLVAS
                     YIRRQLSTLGITPEEKGPYSARAGEVSHLKSDFFFSLPNPEKLGDVLQLLHPTPAVCGL
                     PKEEAYHFIIENEGYDRSYYSGFIGWLDPKGKTDLYVNLRCMNILPQTFTLYAGGGLLA
                     ASQLEDEWQETEDKLDTMRRIVGNL"
     CDS             5255..6943
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg458_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.9e-08, bitscore:
                     21.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLIEHGVSNIVLCPGSRNSPIVHTLANHSFFN
                     CHSVTDERSAGFFAVGLALHGGKPAAVCCTSGTALLNIHPAVAEAFYQKVPLVVISADR
                     PAAWIGQMDGQTLPQPGVFGSLVKKSVQLPEIHTDQDEWYCNRLINEALLELNHHGKGP
                     VHINVPISEPLFQFTTPELPKVRVITRYQGLNVYDRKYDDLIERLNKYSKRMMIAGQMS
                     LIYLFEKKICKLLYKHFTWLSEHIGNRIVPGLPIKNFDAILYATPEEEKEKLVPELVIT
                     YGGHIVSKRLKEFLRKHPPKEHWHVSLDGEVADLFGSLTTVIEMDAFEFLEKIAYMLEN
                     RQIEYPKAWEYKSRNLPEPEFAYSEMAAIGGLIRSLPAESALHLGNSSTVRYAQLYTVP
                     ETVEVCCNRGTSGIEGSLSTAIGYASASQKLNFIVIGDLSFFYDMNALWNGNLHNNLRI
                     LLLNNGGGEIFQALPGFKMNERTHRYVTASHQTSAEGWATERGFSYSAVHNAEELAAAM
                     SAFTQTEQPSEHPLFMEVFTDKAEDVRLLKEYYHQLKNSSQAQNI"
     CDS             6947..7771
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg458_6"
                     /sec_met_domain="ECH_1 (E-value: 2.7e-82, bitscore: 265.4,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METKREWTTIKEYEEILFDFYNGIARITINRERYRNAFTPTTTTE
                     MSDAFYICRERPDINVVVLTGAGDTAFCAGGDMNVKGRGGYVGKDGVPRLNVLDVQKQI
                     RSLPKPVIAAVNGFAIGGGHVLHVVCDLTIASENAIFGQTGPRVGSFDAGFGSSYLARV
                     IGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLDKLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATMLYYMTDEAQEGGKAFLEKRRPRFEDYPKFP"
     CDS             7809..8867
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg458_7"
                     /sec_met_domain="MR_MLE_C (E-value: 1.6e-30, bitscore:
                     95.9, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKERFYKTEVVPRCLTFKRPAGTSRGVYTTRKLWEVRIRKEDEP
                     SVIGIGECAPLPDLSCDYGVDYEITLSKACLDLEQKGYVDTESLRHYPSILFGLEMAMR
                     HYEQGGWRHYDTPFSRGQAGIPINGLIWMGDYKYMLEQVEEKMKEGFRCVKLKIGAIDF
                     DRELSLLKHIRTHFSAKEIELRVDANGAFTPPEAMDKLKRLAEMDLHSIEQPIRAGQLE
                     EMAHLAAESPLPIALDEELIGCNAPDEKRRLLETIHPQYIILKPSLHGGISGCTEWIHL
                     AEAILGSTPEQPKWWVTSALESQIGLNAIAQWCATLGNPLPQGLGTGEIFKDDKHRLIQ
                     RKGDTIWFTNDL"
     CDS             8871..9938
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 52.4; E-value:
                     1.1e-16)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg458_8"
                     /sec_met_domain="AMP-binding (E-value: 1.9e-17, bitscore:
                     52.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIQEDLQAFLAEWHDPSPFLEVQTSGSTGTPKRMRVRKDRMLNS
                     ARLTCDYLGLKKGDKALLCMPLRYIAGKMMVVRSLYAGLDLEVREPSGHPLADWGDTPL
                     RFAAMIPLQVYNTLRVPEERKRLEQTDILIIGGGAIDAALEQEIRQMPNTVYSTYGMTE
                     TLSHVALRRLNGPEASPYYHPFPSVTLSLSPDNTLVIDAPLVCDERLVTNDVARLLPDG
                     SFAIIGRKDNIINSGGIKIQIEEVEERLRPYLDLPYAITAAPDPRLGEAVVLLIAPRSC
                     ETVSPPRVTPHMKAIMSDSAQLSCEVSTVALASLPKYLRPRHVIEASEIPQTGSGKIDR
                     AACRELARNIITKTL"
     CDS             9941..11899
                     /locus_tag="ctg458_9"
                     /transl_table=11
                     /translation="MKRILTITAVSLLALSPMYGQDSCRYPQDPTLEKSQAYAGYDCVT
                     LLDSTAVTVQPTGSGAFAVCKAFKVQTPKGAVANRIIKYDYDPLTAHAEFRYATIYRAN
                     GDVINLDVTGACDYAAPARAIYWGARQIMLEVGRLQPGDVVEYEIAKKGFTYALLTAGD
                     DERFIPPMRGQFYDIVPFWATEPTVRKVYRVSMPMEKELQFQFYQGECTSSMRYEDGRK
                     VYTFASDDILPFAKEPNMVDLFDAAPKLMMSSTPRWEDKSVWFNKVNEDYGSFTAIPEA
                     QRKVDELIKGKKTEMEKIAVLTHWVADNIRYSGISMGKGEGFTLHNLKMNYTDRCGVCK
                     DIAGTLIAFLRMAGFEAYPAMTMAGSRVESIPADHFNHCVAVVKLASGTYMPLDPTWVP
                     FCRELWSSAEQQQNYLPGVPEGSDLCLTPVSAPENHYVRIHADNRLDEKGTLRGQFTIT
                     AEGQSDSNIRRIFTTGWQSDWQNTMEKQLLAVSPNAKLLRVDYGKDPKNYQAAPIKITF
                     SYEIPDYAIIAGDQMLIKPLVMNNLYNQVKSFLRIDTKPENRAYGFKDACSRLVEQDET
                     IRLPKGYTLLNAPKNDALRSNAADFEGSLSQEGDRNIVLRQKLALKKRVYDAADWKGFR
                     SAVNAYKSYGDYLIIKK"
     CDS             11913..13496
                     /locus_tag="ctg458_10"
                     /transl_table=11
                     /translation="MIKITYKLILLLSLLAMTVTSFAASEAEYGKVSKAWTLHADGSQE
                     YRSSMELTLFTHTAMNSTYGESFIVYNPDFQTLKIHSSYTRQKDGTIVKTPDNAFVEVL
                     PRFAADAPAYNQLKEMVVVHTGLELGATIYLDYSIITKPGYYPALDINERLQETSPVKE
                     CKVSISVPEGIPLACGLYGSPVKAVEESHDGIKEVHWTLRNIPASSREAFQPKNREASP
                     HLVASTYPSGKAALATLDKRLKESQGYESKTFAQFLTDKSGNEQEKVNIIRDHILNNLS
                     TCPIPMAMTGYTVRDIDTVLRSAYGTPLEIAQLLNVMLNAAGIPSEVLAVYPGHLDTDA
                     CGLAAIQTLAVKATVDGKDQYLSASPLTNRGGLDKVVSLSGTSIEIETTPIQIKESRSV
                     AISADQAKDGFAICVLPAISAGIDSWGMSALNSKRSNLFELPSLIREEVTYTVTPAEGM
                     KLQTSTQEQVISKPFGKVTRTITPRGNTIEVVRTIELNKQQFTPAEYSDVRSLIHEWTN
                     PDNRVLLFSL"
     CDS             13598..13759
                     /locus_tag="ctg458_11"
                     /transl_table=11
                     /translation="MKTLKYLLATMLLLGVCNLTHSQKLSLGIFPEPQEVTISSQTYAP
                     SYGYTLRGI"
ORIGIN
        1 aatatgagaa ggaaacatac cgacagcaat ccgagcgtac gggtttgcga aaacgagtgg
       61 cgcagggcct ctgttggtat ccggtcactc cgggacgcag ttattataac tccttaaacc
      121 aattggtgat cgagatcgaa aggacagaag accgggagat cgagcataat tttgagtacg
      181 ggcgcccggt ttgcttcttt acggcagata tcagtggtaa atttaagtat ctggatttct
      241 ccgccacgat cagctacgtg caagaggacc ggatggtggt agttctcccc actccttccg
      301 ccttgatgga tatacaagga aaaagcaatg atctcggcgt gcaactctac ttcgacgaga
      361 ccagctataa aacgatgttt tccgctctct cggacgtgat gcgggcaaaa aacaaccaac
      421 tctctcatct aagggatgta ttgctgggac aggaaaaacc gggacagcgg gaattattcc
      481 cgatccgctt cccttggttg aaccgttctc aggaagaagc cgtaaataag gtattgggag
      541 cgaaacaagt atctatcgta cacggccctc ccggaactgg gaaaacaacc accttggtgg
      601 aagccattta cgagaccctt caccgggaga atcaagtgat cgtttgcgcc caaagtaata
      661 ccgccgtaga ctgcatctcg gagaaactgg tagatagagg cattaacgtc ctgcgcatcg
      721 ggaaccccac tcgtatcaat gacaagatgc tctctttcac atatgaacgc cgtttcgagt
      781 cgcatccgga ttatcccgaa ttatggagca tccggaaagc gatacgggat atacaatcca
      841 atatgcgaaa gaaaagccgg gaggaacggg atacgatccg aaaccgcctc tcccgtttga
      901 aattccgggc gaccgaactg gaagtcaaga tcgatacaga gctgttcgac gaggctcgtg
      961 tcgttgcttg caccttggtt ggctccgcaa accgggtcat gatgaaccgg cacttcacga
     1021 ccttgtttat cgacgaggcc gcccaagcct tggaagccgc ttgctggata gcgatcggca
     1081 aggcggaccg ggtcatacta gcgggcgatc atcaccaatt gccccctact attaaatgta
     1141 tagaagcgga acgagaaggc ttaggacgta ccttgatgca aaagatagcc cacacgaaac
     1201 cggaaacagt ctctctcctg aagatccaat atcgtatgca cgaggatatc atgcgcttct
     1261 cctcccaatg gttctatcat aacgaactcg aatccgctcc cgaggtaagt gggcgaggaa
     1321 tcttgcgact ggacactccc atcgtatggt tcgatacgtc cgagtgcgat ttcacggaaa
     1381 atacgagaga ggagaccatg agccgtgtca acaggcaaga ggcggaattg ctcgtggaac
     1441 aattacgctc ctatatacag aaaatatcca aggagagagt gctggaggag aatatcgact
     1501 tcggattgat ctccccttat aaggcgcagg tacaatacat ccgtaaatta atcaaacagg
     1561 acgctttctt caagccttta cgcagactga ttaccgtaca taccgtagac ggtttccaag
     1621 ggcaagaacg cgatgtcatc ttgatcagtt tggtgagggc caacgaggat ggaaagatag
     1681 gcttcttgaa cgacttacgg cgcatgaacg tagcgatcac ccgtgcccgt atgaaactga
     1741 tgatcttggg agacgcttcc acccttaccc ggcacgcatt ttataaagaa ctctataatt
     1801 atatctccca aagaggtaaa ataatcacga tcaacacgaa acaagagcat gaactataaa
     1861 ttattggtac tggatttaga cggtacactg acaaacagta aaaaagagat caccccgttt
     1921 acgagggaaa cccttctgca agcgcaggaa aaaggattgc atctggtctt agcctccggc
     1981 cggcccacct acggtatcgt gcctttagcc gaggaactga acataaagca atatggtggt
     2041 tttatccttt ccttcaacgg cggtaaggtg atcgacttga tgacagacaa agtacttttc
     2101 gaacaggctt tgccacccga tatcgtacct gttttataca accgctccaa agaagcggga
     2161 ctggctatcc tttcctacaa cggtaaatat atcttaagcg aacacccgga aaataaatac
     2221 gtacaatacg aatctttctt aaccaaaatg aagatcaagg ctaccgacga tttcctgcgg
     2281 gatttgcatc agccagccga taaatgcttg gtggtaggcg aaccggagat gttggtaccg
     2341 ttggaagaga agctccgcca agaattaggg aaacgtatca acgtatatcg ttccgaggca
     2401 ttctatctgg agcttgtccc caaaggcatc gacaaagccg cctcgttatc ccgcttacta
     2461 gagcgaaccc ggataaaaca ggaggaagtg atcgctatcg gcgacggttt caacgatgta
     2521 tccatgatcc gtttcgccgg attgggagtc gctatggcca acgcccagcc ccctgtcaag
     2581 gccaatgccg accgcatcac ccaatacacg aacgatgagg atggagtggc tcgtttcatc
     2641 caagaattgc tttgaaaaaa acacgtacgt attttccgag aaacacgtac atgttttcgc
     2701 gagaacacgt acgtgttttt tcagagacat ttacaccagt atcggcacag gccaatgcct
     2761 atatcggcat aagcctgtac gtatatcgcc gcaaggctac accgatatag gcgtgagctt
     2821 gcgccgatat acgtaaattc ctttcatgga aatgtcttct aactatcaac tattttatgt
     2881 acatttgtat tctaaaccat aaaataagac gccatgaagt acaaattatt agtcttagac
     2941 gtagatggga cgttgcttaa cgacaagaaa gagataactc cccggaccca tgccgccctg
     3001 ttaaaggctc agcagatggg agttcatgtt gtattggcat ccggccgacc caccaacggg
     3061 gttcaaccct tggcggaggc tcttgaattg aatcattacg gtggtttcat attatcttat
     3121 aacggaggtc agatcatcaa tgcccagacc ggagaattga tgttcgagaa acgaatcgat
     3181 ccggccatga ttccttattt gaaccggaag gcgaaggaaa acggttttgc tatcttcacg
     3241 tatcacaagg actatatcct gaccgatagc ccggaaaaca agcatgtcca agaggaggcc
     3301 gaactcaata agatgcgcat catcggtgtg gagaatttcc cggaagcggt ggatttcgca
     3361 ccctgtaagt gtattcttac cagcgatgac gagaacaatc tagtgggtct cgaaaatcat
     3421 tggaagaaac gtctggacgg ggtattggaa gctttccgct ccgaggacta tttcttggag
     3481 gtagctcctc atttcatcaa taagggaaat acgttggcgg tattgatgga gatgctgaat
     3541 atcacgaccg aagaggttgt cgctattggt gatggcgtag ccgacgtatc catgcttcaa
     3601 ttagccggta ccggcgtggc gatgggtaac gcacgcgact ccgtaaaggc ttgcgccgat
     3661 ttcacgacct tatctaataa tatggatggt gtggcggtag cgatcgagaa agcgatcctt
     3721 gccacgatca aacccacgga ggttccgtta gatcaactaa acgcacgggc caaacatgcc
     3781 ttaatgggta atctaggcat tcaatatacc tatgcgtcgg aggatcgtgt ggaagcgacc
     3841 atgcctgtag acgaacggac ccgccagcct ttcggtatct tgcacggagg cgctacgctg
     3901 gctttggcgg agaccgtggc cggactaggt tccatgattc tggcgaaacc ggacgagatg
     3961 gtagtcggca tgcaagttag cggcagccat atgtcgtccg cccacgaggg agacacggta
     4021 cgtgccgtcg ggacgattat ccacaaaggc cgttcatccc atgtgtggaa cgtagacata
     4081 ttcacctcta ccgacaaact ggtttcctcg gtacgggtaa tcaatagcat actaaagaag
     4141 aaatgattcc aagagattct tacgaaataa tagacacgtt gatcaagcaa ggccggagtt
     4201 tcgctatttg gcgtattccc ggtgaggata ggctccattt caggatgcaa agcgccggct
     4261 ctccttgcct attatacgac ataaaagact taaatgaacg gagcggtttt gtaatcgctc
     4321 cgtttcaggt gacagcggaa cgacctatcg ttttaatcca accggattgc tttgaaatcc
     4381 cctccgaatc cgattgggat ttctctcgag agaaaaacga attcccttcg aatgaaatcg
     4441 aaatcccatc cgaatccgag gagaaggaac gatacgctta ccatttctcc ctgtttacca
     4501 gccctttgct aaaaggaagc caagataaac tagtcctatc ccgtagcaaa acgatccgga
     4561 aagatccctc tttctcaccc ggcaaggcat tcttcgccgc agtagaacga tatatccgct
     4621 cctatgtcta cctttgccat accccggaaa ccggaacttg gatgggtggg acaccggaaa
     4681 tcttgttatc cggcgagaaa ggcgactggc aaacggtagc tttggccgga acccaatcct
     4741 tacgagacgg gaaattaccg aaaagctggg accataagaa ttggagagaa cagcaattag
     4801 tcgcctccta tatacgccgc cagctgtcca ccttgggtat tactcccgag gagaaggggc
     4861 cttattcagc ccgggccgga gaggtttccc atttgaaaag cgatttcttc ttctccttgc
     4921 cgaatcccga gaagctgggt gatgtccttc aactattaca ccctactcca gccgtttgcg
     4981 gtcttcccaa ggaggaggct tatcatttca tcatcgagaa tgaggggtac gatcgtagct
     5041 attactccgg tttcatcggt tggctggatc ccaaaggcaa aacagatctg tacgtaaacc
     5101 tccgttgcat gaatatcctc ccccaaacct ttacgctgta tgccggaggc ggtctgttgg
     5161 cggcctcgca gctagaggat gagtggcagg agacagagga taaattagat acgatgcgga
     5221 gaatagtggg taatttataa ttttatatca tataatgtat agcgataaaa agaacatcct
     5281 tcaattggta gccttgctga tagagcacgg cgtaagtaat atcgtgctat gtccggggag
     5341 ccggaactct ccgattgtgc acacattggc aaaccattcg ttcttcaatt gccattccgt
     5401 gacggatgag cgaagcgcgg gattctttgc cgtagggcta gcgttgcacg gaggtaagcc
     5461 ggcggctgtt tgctgtacct cgggcacggc cttgctgaat atacatccgg cggtagcgga
     5521 ggctttctat cagaaagttc cgcttgtcgt gatatccgcc gaccgccccg ccgcatggat
     5581 cgggcaaatg gacggacaga ccttgccgca acccggggtg ttcggctcgc tggtgaagaa
     5641 atcggtacag ctaccggaaa tacatacgga tcaagatgaa tggtattgta atcgattgat
     5701 caacgaggct ttgttggaac tgaaccatca cggcaaaggg ccggttcata tcaacgtccc
     5761 gatctccgag cctttatttc agttcacgac acccgaattg ccgaaggtac gggtaatcac
     5821 ccgttatcaa ggcctaaacg tgtacgaccg gaaatatgac gatctgatcg agcgtttgaa
     5881 caaatatagc aagcgaatga tgatagcggg acaaatgagc ttgatctatc tcttcgagaa
     5941 gaaaatatgc aagttactat acaagcattt cacttggctc tccgagcaca tcggcaaccg
     6001 tatcgtaccg ggattgccga tcaagaattt cgacgccatc ctgtacgcta ccccagagga
     6061 ggaaaaagag aagctggttc ccgagctcgt gatcacctac ggcggccata ttgtctccaa
     6121 gcggctgaaa gagtttttgc ggaaacaccc gcctaaggag cattggcatg tctcattgga
     6181 tggggaggta gcggatttat tcggtagcct gaccacggtg atcgagatgg acgctttcga
     6241 gtttctggag aaaatcgctt atatgctgga gaataggcag attgaatatc cgaaggcttg
     6301 ggaatataaa tcccggaatc tgccggagcc ggagttcgct tactccgaaa tggcggcgat
     6361 cggtggtttg atacgttcgc ttccggctga atctgccttg catctgggga atagctccac
     6421 cgtacgttac gcgcaattgt acaccgtacc cgagacggtt gaggtttgtt gtaaccgagg
     6481 tacgagcggg atcgaaggct ctttgtctac ggccatcgga tacgcctcgg cctcgcaaaa
     6541 actaaacttt atcgttatag gcgatcttag tttcttctat gatatgaacg cattgtggaa
     6601 cggaaacttg cacaataacc ttcgcatcct gctcttgaac aacggaggtg gcgagatctt
     6661 ccaagccttg ccgggattca agatgaacga gcgtacgcac cgttacgtca ccgcctccca
     6721 ccagacctca gcggagggat gggccacgga aaggggattc tcctactccg ccgttcataa
     6781 cgccgaggag ttggcagctg cgatgagcgc ctttacccaa acggagcaac cgagcgaaca
     6841 tcccctattc atggaggttt tcacggacaa agcggaagac gtacgattgc tcaaggaata
     6901 ttatcatcaa ctaaaaaatt catcccaagc acaaaacata taatatatgg aaacgaaaag
     6961 agaatggaca accatcaagg aatacgagga gatcttattt gatttctaca acggcatcgc
     7021 ccgcattacg ataaaccggg aacggtatcg caacgctttt accccgacta cgaccacgga
     7081 gatgagcgac gccttttaca tctgccggga acgtccggac attaacgtag tcgttctgac
     7141 aggagccgga gatacggcgt tttgcgcggg aggcgatatg aacgtgaaag gacgtggcgg
     7201 ctacgtgggt aaagacggcg tacctcgctt gaacgtattg gacgtacaaa agcagatccg
     7261 ctctctcccg aaacccgtca tcgcagccgt gaacggtttc gctatcggcg gcggacacgt
     7321 attgcacgtg gtttgtgacc ttacgatcgc ttccgagaac gctatcttcg gacagacagg
     7381 ccctcgtgtg ggtagcttcg acgccgggtt cggctcttct tacctcgccc gtgtgatcgg
     7441 acaaaaaaag gcccgtgaga tctggttcct atgccgcaag tacaatgcac aggaggcttt
     7501 ggatatgggt ctggtaaata aggtagtccc cttggataaa ttagaggacg agtacgttca
     7561 atgggccgag gagatgatgt tgcttagccc gttggccttg cgcatgatca aggcgggctt
     7621 gaacgccgag ttggacggac aggccggtat acaagagttg gccggagacg ctaccatgct
     7681 ttactatatg acggacgagg cgcaggaagg cggcaaggca ttcttggaga aacgccgtcc
     7741 acgcttcgag gattacccga agttcccgta aagggaattg agaattgaga attgaaaatt
     7801 gagaatgaat ggtgaaggag aggttttata aaacagaggt ggttccccgg tgcttgactt
     7861 tcaagcgacc ggcaggaacc tcacggggtg tttacacgac ccggaaattg tgggaggtcc
     7921 gaatccgcaa ggaagacgaa ccctcggtta ttggtatcgg agaatgtgcc cccctgccgg
     7981 atctcagttg cgattatgga gtggattacg agatcacgtt atccaaggct tgcctcgatc
     8041 tggaacagaa gggatatgtt gacaccgaat ctttgcgcca ttacccatcc atccttttcg
     8101 gattggaaat ggccatgcgt cattatgaac agggtggttg gcggcattac gacacgccct
     8161 tctcgcgggg gcaagcgggc atccccatta acggactgat ctggatgggc gattataagt
     8221 acatgctgga acaggtagag gaaaagatga aggagggctt ccgctgcgtc aagctgaaga
     8281 tcggcgctat cgatttcgac cgggaactct ctttattgaa acatatccgc acgcatttct
     8341 ccgccaagga aatagagctt cgggtagatg ccaacggcgc tttcactccc ccggaggcga
     8401 tggataaact gaagcggctc gccgagatgg acttacattc catcgagcag cctatccgtg
     8461 ccgggcagtt ggaagaaatg gcacaccttg cggcagagtc accccttccc atcgctctcg
     8521 acgaggaact gatcggctgt aacgccccgg acgagaaacg gcggttgttg gaaactatcc
     8581 atccccaata cattatatta aagccttccc tccacggagg tatctccgga tgtacggaat
     8641 ggattcactt agcggaagct atcttaggga gtacccctga acaacctaaa tggtgggtca
     8701 cctccgctct ggaatcgcaa atcggactga acgctatcgc ccaatggtgc gccacgttag
     8761 gtaacccgct accgcaaggt ctgggaaccg gcgagatttt caaggatgat aaacatcggt
     8821 tgatccaacg aaaaggagac accatctggt tcaccaacga cctttgacct atgccgatac
     8881 aagaagattt acaggcattc ttagctgaat ggcacgatcc ctcccctttt ctggaagtcc
     8941 agacctccgg ctccaccggt acgcccaagc ggatgagagt gcgcaaggac cggatgctga
     9001 acagcgcccg gcttacctgc gattatctgg gtcttaagaa gggcgacaag gccctgttat
     9061 gtatgcccct gcgctatata gccggaaaga tgatggtggt ccgctcccta tacgccggac
     9121 tggatctgga ggtgcgtgaa ccctccggac acccgttggc ggattggggg gatacgcccc
     9181 tgcgctttgc cgccatgatc cccttgcagg tttacaatac gttgcgagta cccgaggaac
     9241 gtaaacggct ggagcaaacg gatatcctga ttatcggcgg cggggcgatc gacgcggcct
     9301 tggaacagga gatacggcag atgccaaaca cggtttattc cacctacgga atgacggaga
     9361 cgctgtctca cgtcgccctg cgccggctga acgggccgga agcctcgccc tattaccatc
     9421 ccttcccctc ggtgacgtta tccttgtcgc cggacaatac cttggtgata gacgccccat
     9481 tggtttgcga cgagcggctg gtgacgaacg atgtcgcccg cctgctgccg gacgggagtt
     9541 tcgccattat cggaaggaaa gataatatca tcaatagcgg aggaatcaaa atacagatcg
     9601 aggaggtgga agagcggcta cggccctacc tagacctccc ctatgccatc accgccgccc
     9661 ccgaccctcg gttgggagag gcggtagtct tactaatcgc cccaaggtca tgtgaaacgg
     9721 tatcaccccc tcgggtgaca ccacacatga aagctatcat gagcgactcc gcgcagctat
     9781 catgtgaggt atcgacagtg gctctcgcca gcctgcccaa gtacctccgt ccaaggcacg
     9841 tcatagaggc aagcgagatc ccccaaaccg gaagcggcaa gatcgatcgt gccgcctgcc
     9901 gggagctagc gagaaatatc atcacaaaaa cactataaac atgaaaagga ttctaacaat
     9961 caccgcggtc tccctattgg ccttatcgcc tatgtacggg caggattctt gccgataccc
    10021 gcaagatcct accttggaga aatcgcaagc ctacgcagga tacgactgcg tcaccttgct
    10081 ggacagcacc gccgtcacgg tacaacctac cggctcgggg gctttcgccg tatgcaaggc
    10141 ttttaaggta cagactccca agggagccgt cgccaaccgt atcatcaaat acgattacga
    10201 cccgctgacg gcgcatgccg agtttcgtta cgccacgatc taccgtgcga atggcgacgt
    10261 gatcaatctc gacgtgactg gggcttgcga ctatgccgcc cccgcacgtg ccatctactg
    10321 gggcgcccgg cagatcatgc tggaagtggg ccgcctgcaa ccgggagatg tcgtggagta
    10381 cgagatcgcc aagaaaggtt tcacctacgc cttgctgacg gcgggcgacg acgagcgttt
    10441 catccctcct atgcggggac agttttacga tatcgtcccc ttctgggcta ccgagcctac
    10501 cgtgcgtaag gtataccggg tatccatgcc gatggagaaa gagttgcaat tccagttcta
    10561 ccaaggcgaa tgtacctctt ccatgcgata tgaggatgga cggaaagtat ataccttcgc
    10621 ctccgacgat atccttcctt tcgccaagga accgaatatg gtagacctat tcgacgctgc
    10681 cccgaagctc atgatgtcca gcacgccccg ctgggaagat aaatccgtat ggttcaataa
    10741 ggttaacgag gattacggaa gctttaccgc gatcccggaa gcccaaagga aggtagacga
    10801 gctgatcaaa ggcaagaaga cggaaatgga gaagatagcc gtattgaccc actgggtagc
    10861 cgataacatc cgttactccg gaatctcgat gggtaaaggc gagggtttca cgcttcacaa
    10921 cctaaagatg aattataccg atcgttgcgg tgtctgcaag gatatcgccg gtacgttgat
    10981 cgccttcctc cgcatggccg gattcgaggc ttacccggcg atgaccatgg cgggaagccg
    11041 tgtagaaagc atccccgccg accatttcaa ccattgcgtg gcggtggtaa aactggctag
    11101 cggcacgtat atgcctctcg acccgacttg ggttcctttc tgccgagaat tatggagtag
    11161 cgccgagcaa cagcagaact acctcccggg tgtgcccgaa ggctccgacc tctgcctgac
    11221 ccctgtctcc gccccagaaa accactacgt ccgcatccac gctgacaacc gcctagacga
    11281 gaaaggcacg ctccgcggac aattcacgat caccgccgag ggacagtccg acagcaatat
    11341 ccgccgcatc ttcaccaccg gatggcaatc cgactggcag aacacgatgg agaagcaatt
    11401 gctggccgta tcccccaacg ccaaactgct tcgtgtagat tacggtaagg acccgaagaa
    11461 ctatcaagcg gcccctatca agatcacgtt ctcttatgag atccccgatt atgcgatcat
    11521 cgccggagac cagatgctta tcaagccgct agtcatgaat aacctctaca atcaagtgaa
    11581 gagtttcttg cgtatcgata cgaaaccgga aaaccgtgcg tatggattca aggacgcttg
    11641 ctcccgtttg gtagaacaag atgagaccat ccgtctcccc aaaggctata ccctcctgaa
    11701 cgccccgaag aatgacgccc tgcgaagcaa tgcggccgat ttcgaaggtt ccctttcaca
    11761 ggaaggcgac cggaacatcg tcttgcgcca gaagctagcg ttgaagaagc gtgtctacga
    11821 cgcagccgac tggaaaggct tccgttccgc cgtgaacgcc tataagagtt atggtgacta
    11881 tttgattatc aagaaataaa aaaagaaaga caatgattaa gataacctat aaactgattc
    11941 ttctcctaag cttgttagcg atgacggtta cttcattcgc cgcatcggag gctgagtacg
    12001 ggaaagtatc gaaagcttgg accttgcatg ccgacggcag ccaagaatat cgatcctcca
    12061 tggagttgac gctcttcacg cataccgcaa tgaatagcac gtatggcgag agttttatcg
    12121 tctacaatcc cgatttccaa acactgaaga ttcactcatc ctatacgagg cagaaagacg
    12181 gtacgatcgt aaagacaccc gataacgcct tcgtggaggt cctgccccgt ttcgccgccg
    12241 acgctccggc ctataaccaa ctcaaggaaa tggtcgtggt acacactggc ctagaacttg
    12301 gggccacgat ttacttggat tactctatta tcacaaaacc gggctactat ccggctctgg
    12361 atatcaacga gcgactacaa gagacctctc ccgtgaagga atgcaaggtc tctatttccg
    12421 taccggaagg gatccccttg gcttgcggtc tatacggctc ccccgtaaaa gccgtggaag
    12481 agagccatga cggtataaag gaggtacact ggacactacg gaacattccc gcttcctccc
    12541 gtgaggcttt ccaaccaaag aaccgtgagg cttcacccca cttggtagcc tctacctatc
    12601 cttcaggtaa agcggcctta gccactttgg ataagcgctt aaaggaatcg cagggatacg
    12661 agagcaaaac cttcgcccaa ttcctcaccg ataaaagcgg taacgaacaa gagaaggtga
    12721 acatcatccg agaccatata ctcaacaatc tcagtacctg tcctatcccc atggcgatga
    12781 ccggctatac cgtccgtgac atcgataccg ttctccgcag tgcttacggt acgccgctag
    12841 agatcgcaca gctcttgaac gtgatgttga atgccgccgg aatcccgtcg gaagtcctcg
    12901 ccgtctatcc cggccatctc gatacggacg cttgcgggct ggctgccatc cagacactag
    12961 ccgtaaaagc cactgtcgat gggaaagacc aatacctatc cgcctccccg ctgacaaatc
    13021 gtggcggact agataaggta gtctccctct ccggaacttc cattgagatt gagaccacac
    13081 ctattcagat taaggaaagt agatccgtgg ccatctccgc cgatcaagca aaagacggtt
    13141 tcgccatctg cgtattgcca gccatctccg ccggaatcga tagctggggc atgagtgcct
    13201 tgaacagcaa gcgttccaac ttattcgaac tcccctccct aatcagggaa gaggtaacat
    13261 acacggttac tcccgccgag ggcatgaagt tgcagacctc cacgcaagag caagtgataa
    13321 gcaagccttt tggtaaagta acccgcacga tcacaccaag aggaaatacg atcgaggtgg
    13381 tacgtacgat agagttgaac aagcaacagt tcactcccgc cgaatatagc gacgtgcgta
    13441 gcttgatcca tgaatggaca aatccggata accgggtatt gctattctcc ctataagatc
    13501 taaatacgga gggcacggaa caaatctgtg tattccgtgt gctccgtgtt taattatttc
    13561 atacatttac gaacgttaac attaaatcat atcgtatatg aagacactaa agtatttact
    13621 cgccaccatg ctccttctag gcgtttgtaa cctaacgcat agccaaaagc tatccctagg
    13681 aatcttcccc gagccccaag aggtgactat ttccagccaa acatacgcac cgtcctatgg
    13741 atatacccta cggggtataa a
//
