LOCUS       c00025_gnlPro..        13311 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EEKHFPOB_25.
ACCESSION   c00025_gnlPro..
VERSION     c00025_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 08:33:01
            Original ID  :: gnl|Prokka|EEKHFPOB_25
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13311
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13311
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[352:3311]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      353..3311
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..13311
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13311
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             353..2581
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_1"
                     /sec_met_domain="Gly_radical (E-value: 1.2e-46, bitscore:
                     148.8, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1167.1, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNKTFKDGLWSKEINVRDFVSNNITPYEGDASFLQGPTERTKA
                     VWNHCLKALEEERNNNGIRALDYTTVSTITSHPAGYIDKENELIVGLQTDQVLKRAIKP
                     FGGINVVMKACRENGVEVDDRVKDIFTHYRKTHNDGVFDVYTEEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRLALYGLDRLIEAKKEDLHNLTGPMTEARIRLREEVAEQIKALKEIK
                     VLGEYYGLDLSRPAYTAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYLEYELSQ
                     GTITETFAQELIDQFVIKLRMVRHLRMQSYNDIFAGDPTWVTESIGGRFNDGRTKVTKT
                     SFRFLQTLYNLGPSPEPNMTVLWSPELPEGFKAFCAQVSIDTSSVQYENDDLMREVRQS
                     DDYGIACCVSYQEIGKQIQFFGARANLAKALLLAINGGRCENTGTVMVKDIPVLTGETL
                     KFEEVMANYKKVLIQIARVYNEAMNIIHYMHDKYYYEKAQMAFVDTDPRINLAYGVAGL
                     SIAIDSLSAIKYAHVKARRNDIGLTEGFDIEGAFPCFGNDDDRVDHLGVDLVYFFSEEL
                     KKLPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGIAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDSQDGISNTFSIVPKSLGATQEDRIDNLVTMMDGYFTKGAHHLNVNVLN
                     REMLQDAMEHPEKYPQLTIRVSGYAVNFVKLSREHQLEVISRSFHERM"
     CDS             2586..3311
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 72.3;
                     E-value: 1.6e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_2"
                     /sec_met_domain="Radical_SAM (E-value: 1.6e-30, bitscore:
                     97.8, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVHSYESMGTFDGPGLRLVVFLQGCNFRCLYCANPDTIEAKGG
                     TATDPEEIVRMAVSQKAFFGKKGGITFSGGEPTFQAKSLIPLFKRLKEAGIHICLDTNG
                     GLWNNDVEELLELTDLVLLDIKEFNPEHHQSLTGRSNEQTLKTAAWLETNHKPFWLRYV
                     LVPGYSDFEDDIRQLGEHLGTYQMIQRVEILPYHTLGVHKYEAMNKEYMLKGVKENTPE
                     QIEKAEKLFRQYFRTVQVN"
     CDS             complement(3543..4802)
                     /locus_tag="ctg25_3"
                     /transl_table=11
                     /translation="MKEDEKWIKAFKDKLEDYSEPMPASGWERLERELMPVTEKRIYPY
                     RRWAVAAAAVVLVVTTAVSLYFLNSPVADEIRYATAPSLAVNPDVLPEPALPDVQVAVS
                     EPVKPVGTTSINPVSGYLAKNTDPVIVPEVSSLAEKRPEAVTEEKRTEPQQEATAAIEK
                     KESATAQPPKRKEARRPSGKDKYQLPIGDSSAKRGGKWSMGVGIGNGGGLPTNGSENFA
                     PRPMTNRVDLMTIMNGAVSIPADQEVIFEEGVPYLKSNTTAVMDYEHHQPVSFGLSVRK
                     SLPKGFSVETGLTYTLLSSDIKRQGDTKMQSQKLHYIGIPVRGNWNFLEKKYFTLYVSA
                     GGMVEKCVYGKLADDKVNVKPLQFSVAGAVGAQFNATDHVGLYVEPGVSYFFDDGSKVQ
                     TIRKERPCNFNLQAGLRFTY"
     CDS             complement(4857..5405)
                     /locus_tag="ctg25_4"
                     /transl_table=11
                     /translation="MNELELSERCRQGDNRARKELYEQYAGRMLGVCLRYAGDRDMAQD
                     LVHDGFLKIFDSFDKFTWRGEGSLRAWMERVMVNTALQFLRKNDVMNQTTALDEVPETY
                     EEPDASAVEAIPQKVLMQFINELPAGYRTVFNLYTFEDKSHKEIAQMLGINEKSSASQL
                     FRAKSVLAKKVKEWLVTNG"
     CDS             5725..6345
                     /locus_tag="ctg25_5"
                     /transl_table=11
                     /translation="MKIPNADTPRDFFIALDNGDNVLPADTADIRNRKYTVAEGQRVFV
                     GYLQMGEEKPGYENGKIFTIEDILTKEIIPLTEATADSIGDDRINVTAHALTKDYLTIE
                     YQYLGSMNENKKHMLNLVQNEITGPIKDDGYIYLEFRHNAFNDSPNQLGSSLVSFKLDS
                     IAEQLATAKGIKLRVNTIYDNIQYVTIDINEDKNLKIKSFHSQ"
     CDS             complement(6450..7448)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     -3.5; E-value: 38)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg25_6"
                     /sec_met_domain="LysR_substrate (E-value: 8.6e-47,
                     bitscore: 150.3, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 2.5e-18, bitscore: 57.0,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRVKLKISIFALIDSISLINQRTMTIQQLEYILAVDQFRHFAKA
                     AEYCRVTQPTLSAMIQKLEDELGVKLFDRSMTPVCPTAIGKKVLEQARKILSEVICVKE
                     IISEEQHSLSGTFRLAVLPTIAPYLLPRFFPQLMEKYPDLDIRVMELKTPDIRKALLTG
                     EVDAAIIASMLDDAALTEETLFYEQFLGYVSKKEPLFKHDVIRTSDVTGERLWLLDEGH
                     CFRDQLVRFCQMEAVKISQMAYRLGSMETFMHMVESGKGITFIPELAVMQLSEEQKELV
                     RPFAIPRPTRQIVLVTRKDFIRTSLLQVLKEEIQAAVPKEMLTLQAVQCLV"
     CDS             7518..7991
                     /locus_tag="ctg25_7"
                     /transl_table=11
                     /translation="MKTLNYTHLEEKGANTIVLSLQQLLADFQIHYANLRGFHWNIKGH
                     GFFVLHSKFEDLYNGAAEKVDEIAERILMLGGTPANRYSDYLKMAQIKEVDGVNKADDA
                     LNHILETYGHLIAEERKILSLASSHNDEVTVAMMSDYLKEQEKMVWMLTAYNG"
     CDS             complement(8073..9071)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_hydro_130"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg25_8"
                     /sec_met_domain="Glyco_hydro_130 (E-value: 7.6e-70,
                     bitscore: 226.4, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEIKIAGAALPAMPWEERPAGCKDVVWRCSANPIIPRDLLPTSN
                     SIFNSAVVPFKDGYAGVFRCDDTNRRMRLHVGFSKDAVHWDINEEPLKFQCDDAEVGTW
                     VYGYDPRVCFIEDRYYVTWCNGYHGPTIGVAYTYDFVTFHQLENAFIPFNRNGVLFPRK
                     INGRFAMLSRPSDNGHTPFGDIFYSESPDMEFWGRHRHVMSPAPFEDSAWQCTKIGAGP
                     IPIETSEGWLLIYHGVLASCNGFVYSFGSALLDIDQPWKVKFRSGPYLISPQKDYECMG
                     DVPNVCFPCAALHDSETGRIAIYYGCADTVTGLAFGYIPEIIEFTKRTSII"
     CDS             complement(9126..10394)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg25_9"
                     /sec_met_domain="MFS_1 (E-value: 2.1e-11, bitscore: 34.4,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKPISPVCWVPTVYFAMGLPFVALSMVSVLMFSDMEVSNAQIA
                     FWTSLIMLPWTLKPLWSPFLEMFKTKKYFVVATEIITGLAFALVALSLPLPDFFRYAIA
                     LMGIIALSGATHDIAGDGVYLTELTATQQAKYIGWQGAFYNLAKILANGGLVWLAGMLK
                     DEFGVVHAWMIVMLMCAGIMILIGLYHIRILPSGGGASGEVNTMSDALNMLWEVIRSFF
                     QKKHIAFYIVFIILYRFAEGYAIKIVPLFLKASVADGGLGLSTQDIGLVYGTFGAGAFI
                     LGSLLAGYYISAFGLRKTLFSLCCAFNIPFLVYFLLALYQPSDLWIIGMAIVSEYLGYG
                     FGFVGLMLFMMQQVAPGKHQMAHYAFATGIMNLGVMLPGMMSGYLSDWLGYRDFFIWVL
                     IATIPAFIVTWLVPFTYPDGKKK"
     CDS             complement(10644..11657)
                     /locus_tag="ctg25_10"
                     /transl_table=11
                     /translation="MNRHLNFVTLICLITGFVSLASCSNDDDEMDKYQKIYIRTGVAPG
                     AEMGAAVVVDCVSNSSTADRSDFEIQLCAVQPVTRDVTAALGVDTLKVDTYNSANKTKC
                     KLLPQDNYTIETSEVVLKTGQTVADSSFQVVLKNIEKLTNPDGYVLPVALKGVMGMDEQ
                     AVSTSMKTVYIRIYTSVLYTSYTKPGNWSAVDRSAWSVSCSNVYADDDAKYGAHLAIDG
                     EINTTWFTWGVANAGECWWNTVLDRPVTLTGFSVTKQSAYGSGYNLRSAEIKVRKEGET
                     EWVTYPRVLTFRNFKGADPQYAAIEPPIPNVKEFRINCLTPDNYTGFAEINLYVKQ"
     CDS             complement(11680..12837)
                     /locus_tag="ctg25_11"
                     /transl_table=11
                     /translation="MTLKNLIMKRITIKQYLLACFVLPMILAGCNDADYQVIDNAIYLN
                     EASENGSAKVTVDPENVTTTTLTVRVGQPVTENVTAVLTVDPSILKEYNEANETSYEVL
                     PEQYFTYDKEIKIAAGDVSAIPSEFRVKPYSNENGELYAIPVSLTEIQGPVSTIGLSSK
                     FIILLDKPLIQSVPFMNTTNAVKPAKDELWGVTTNEWSLEAWVQMDGFDINNQAIFNSG
                     SSDHEVYIRFGDAMIPYNSLQVKTLGSQVNTVTLFEKNKWYHLAFVYNSSGLLSIYING
                     VLDVTLQTKGGPVRFDKMNMVSSGSYFRNNCQMAQVRLWKSAISQTQIQSNMYFAVKPA
                     DPNLIGYWKMDEGKGNAFVDCTGHGYDLVAGGTLVWKEHVRFDKQ"
ORIGIN
        1 tcagcgttta ttgcggagag acagggattc gaaccccggg tacctcgcag tacaacggtt
       61 ttcaagaccg ccgcaatcga ccactctgcc acctctccag aactacggtt aagtagtgct
      121 tttctcttaa agcgctgcaa aggtacgaat cattttttaa cttgcaaatt attccgcaaa
      181 aaaatattag aaaagtatat ttggaagtaa taactgctat ctggcttctc cccataaata
      241 ggtattttta tgctattcaa cataaaatag gaccctttta tatacctaaa ccgaaaaaag
      301 gttgtaaatt tgcgcgctct aaaggataac taaccactaa ctgattaatt ttatggaact
      361 gaataagacc tttaaagatg gactttggag caaagaaatc aatgtaaggg atttcgttag
      421 taacaacatc actccttatg aaggggatgc ttctttcctg caaggaccta ccgaacgcac
      481 caaagctgtc tggaatcact gtctcaaagc tctcgaagaa gagagaaaca ataatggtat
      541 tcgtgcactc gactacacaa ctgtatctac tataacctct caccctgccg gctacatcga
      601 taaagaaaac gaactgatcg tcggactaca gaccgatcag gtgttaaaac gtgccatcaa
      661 accgtttggc ggaatcaatg tggttatgaa agcttgccgt gaaaacggag tggaagtaga
      721 tgacagagtt aaggatatct tcactcacta tcgcaagact cacaatgatg gggtattcga
      781 tgtgtatacc gaagaaattc gttcgttccg ttcattggga ttccttaccg gacttcccga
      841 caactatgca cgcggacgta tcatcggtga ttatcgccgc ctggctctct atggtcttga
      901 ccgtctgata gaagctaaaa aagaagatct gcataatctg acaggtccta tgactgaagc
      961 ccgcattcgt cttcgtgaag aagtagccga gcaaatcaag gccctgaaag agattaaagt
     1021 attgggcgaa tattatggtt tggatctgag ccgaccggca tataccgcac aggaagctgt
     1081 acaatgggtg tatatggctt atctggctgc cgtaaaagag caggatggtg ctgccatgtc
     1141 actgggtaat gtatcttcat tcctcgacat ctatcttgaa tatgaattaa gccagggtac
     1201 gataaccgaa acattcgctc aggaactgat cgaccaattc gttatcaaac tccgtatggt
     1261 acgccacttg cgtatgcagt cgtacaacga tatttttgcg ggtgatccca catgggtgac
     1321 cgaatctatc ggtggacgtt tcaatgacgg acgtaccaaa gttactaaaa cttctttccg
     1381 cttcttgcag acactttata acttaggccc gtcaccggaa cctaacatga ctgtactatg
     1441 gagccctgag ttacccgaag gcttcaaagc attctgtgca caagtatcta tcgacacttc
     1501 ttccgtacaa tacgaaaacg acgacctgat gcgtgaagtc cgtcaatcgg atgactacgg
     1561 aatcgcttgt tgtgtttcat atcaggaaat cggaaagcag attcagttct tcggcgcacg
     1621 tgccaacctt gccaaagccc tgctactggc tatcaacgga ggacgttgcg aaaatacagg
     1681 tacagttatg gtaaaagaca tccctgtatt gaccggtgaa acactgaagt tcgaagaagt
     1741 aatggccaac tataagaaag tattgataca aattgcacgt gtatacaacg aagcaatgaa
     1801 tatcatacat tacatgcacg ataagtatta ctacgaaaag gcgcagatgg ctttcgtgga
     1861 tactgatccc cgcattaacc tcgcttatgg tgtagccgga ctttcaatcg ccatcgattc
     1921 actgtccgcc atcaaatatg cacatgtgaa agcccgtcgc aacgacatcg gactgacgga
     1981 gggattcgat atcgaaggtg ctttcccttg tttcggtaat gacgatgacc gtgtagacca
     2041 cctgggtgtg gacctggtat atttctttag cgaagaatta aagaaactcc ccgtatataa
     2101 gaatgcccgt cctacccttt cgctgctgac tatcacttcg aacgtaatgt atggcaagaa
     2161 gaccggtgcc actcctgacg gacgcgccaa aggcattgcc tttgctcccg gtgccaaccc
     2221 catgcacgga cgtgataaaa atggtgcaat cgcctcactg agttctgtag ccaagttgcg
     2281 ttatcgcgac tcacaggatg gtatcagcaa tacgttctcg atcgttccca aatcattggg
     2341 agcaacacaa gaagaccgta tcgacaatct ggtgaccatg atggacggat attttacaaa
     2401 aggcgcacac cacctgaacg taaacgtgct gaaccgggaa atgttgcagg atgcgatgga
     2461 acatcccgaa aagtatccgc aactgactat ccgtgtctca ggatatgccg ttaatttcgt
     2521 gaaattgagc cgcgaacatc agttggaagt aatcagccgc agtttccacg aaagaatgta
     2581 attgaatgat aaacgtacac tcatacgagt caatgggaac attcgacggg ccgggtctcc
     2641 ggctcgtcgt tttccttcaa gggtgtaact tccgttgcct ctattgtgcc aatccggaca
     2701 caattgaagc caaaggaggg acagcaaccg accctgagga aatagttcgc atggccgtca
     2761 gtcagaaagc tttcttcggt aaaaagggag gtatcacctt ttccggcgga gagcctactt
     2821 ttcaagcaaa atcgcttatc ccacttttta aaagactaaa ggaagcagga atccatattt
     2881 gccttgatac caatggcggg ctatggaaca atgatgtaga ggaactattg gaattgactg
     2941 atctggtttt attagatatc aaagaattta atccggaaca tcatcagtct ttaaccggaa
     3001 gaagcaacga gcagaccctg aaaaccgcag cctggcttga aaccaatcat aaaccattct
     3061 ggttgcgata cgtattagtg cccggctaca gtgacttcga agacgatatc cggcagctgg
     3121 gagagcatct tggaacgtac cagatgattc agcgtgtaga aatattgcct taccacacct
     3181 tgggtgttca caaatatgaa gcaatgaaca aagaatatat gctgaaagga gtgaaagaga
     3241 atactccgga gcagatagaa aaggctgaga aactattcag gcaatatttc cggaccgtac
     3301 aagtgaattg acttatataa gtgtcgaaat tcgtattcgc cacagattac acgaatttac
     3361 acagataaag atcattggca atcaatagat taagttcact ctgcggtaaa ttatgacgat
     3421 tgcgcttatt tataattttg taagtcacga cataaaaatc tccctgttct tgccttaatt
     3481 cattacaata caaggcaaga acagggagat aatgtaaccg gtatattttt tgccatccta
     3541 ctttaataag tgaatcgcaa tcctgcctgc aagttaaagt tacaaggcct ttcttttcgg
     3601 atggtttgta ctttggagcc atcatcaaag aaatacgaaa ctcccggttc cacatatagg
     3661 ccgacatgat ctgtcgcatt gaattgcgct cccacggcac cggctacaga aaattgcaaa
     3721 ggcttcacat tcaccttatc atccgccaac tttccataaa cacacttttc aaccattcct
     3781 ccggcagata catagagtgt aaaatatttc ttttccagaa aattccagtt tccacgtaca
     3841 ggaataccta tataatgcaa tttctgactc tgcatcttgg tatccccctg ccgtttgatg
     3901 tcagaagaca acaacgtata agtcaatccc gtctctacag agaaaccttt gggaagagac
     3961 ttacgtacag acagtccgaa gctaaccggc tgatgatgtt cataatccat cacggcagtt
     4021 gtattggact tcagataggg aaccccttct tcaaatataa cttcctgatc ggcaggaata
     4081 ctcacagctc cattcatgat cgtcatcaag tcgaccctgt tagtcatcgg acggggcgca
     4141 aaattttcgg aaccatttgt cggaagtcca cctccattac cgatacccac tcccatcgac
     4201 catttaccac cacgtttagc agaagagtct ccgataggca actgatactt gtctttaccg
     4261 gacggtcgcc gcgcttcttt cctctttgga ggctgcgccg tcgcactttc ttttttctcg
     4321 attgcagcag ttgcttcctg ttgcggctca gttctctttt cctccgtcac tgcctccggt
     4381 cgcttctctg ccaaggagga tacctccgga acaatcaccg gatcagtatt ctttgccaaa
     4441 tagcccgaaa cagggttgat actcgtcgtt cctaccggct taacgggttc ggatacagct
     4501 acctgtacat ccggcaaggc aggttccggc aatacatccg ggttgacagc cagtgaagga
     4561 gccgttgcat aacggatttc atcagctacc ggactattca gaaaatacaa actgacagca
     4621 gtcgttacca ccaataccac agctgccgca gcaaccgccc accggcgata cggatatatt
     4681 cgtttttcgg ttacaggcat cagttccctt tccagtcgtt cccaaccgga agcaggcatc
     4741 ggctccgaat aatcttcgag cttatccttg aatgctttaa tccatttttc gtcttctttc
     4801 atcattctat ttcatttttg aaatccaagg ttcacctcag tatctgtaaa tacatgtcaa
     4861 ccattggtca ccaaccattc tttcactttc tttgccaata cactttttgc gcgaaaaagc
     4921 tgtgaggcag aagatttttc attaatcccc aacatctgtg cgatttcctt gtgcgactta
     4981 tcttcaaagg tgtataaatt gaatacggta cgatatccgg cggggagttc attaataaat
     5041 tgcatcagca ctttctgtgg tattgcttca acagccgaag catccggttc ttcatacgtt
     5101 tcgggaactt catccagtgc cgtggtctgg ttcatcacgt cgttctttct taagaactgt
     5161 aaagccgtat tcaccattac acgctccatc catgctctca gagagccttc accccgccag
     5221 gtaaacttgt cgaaggagtc gaaaatcttc aggaaaccgt cgtgtaccaa gtcttgtgcc
     5281 atatccctgt ctccggcata acgaagacag acaccaagca tgcgccctgc gtactgctca
     5341 taaagttctt tgcgggcacg attatctccc tgcctgcaac gttccgacag ctctaattca
     5401 ttcattctcc taaacacgtg tttaccttat aaatgcagca aagatagaaa tactgcacag
     5461 agagaacaac tcttttatca cttttgtttc tttaacattt taggatgcaa tatttcatca
     5521 cttcctgcat tttctcaata caataaagaa taaatctcaa tggataaata ggataaaacc
     5581 aacaagaaac ttatgaagaa atttaattta ataacttttg ccgtcatcct gatgttattg
     5641 cccattttac agtcatgtct ggacgatgcc aacaacgacg agtgggtcac ttgtcctccg
     5701 ggtggaatat tggccatcgg cacaatgaag attcccaatg cggacactcc aagggacttt
     5761 ttcattgcat tggacaatgg agacaatgta cttccggcag atacggccga tatacgcaac
     5821 aggaaataca ctgttgcaga aggtcaaaga gtcttcgttg gctatctgca gatgggagaa
     5881 gagaaacccg gatatgagaa cggtaaaata ttcacgatag aagatatatt gacgaaagag
     5941 atcattccac tgacggaagc tacagcagac agcattggag acgaccgtat caacgtcaca
     6001 gcgcatgcac ttacgaaaga ttatctgacc atcgaatatc aatatctggg cagcatgaat
     6061 gaaaataaaa aacacatgct gaacttggta caaaacgaaa taacaggtcc cataaaagat
     6121 gacggatata tctatctgga gttccggcat aatgccttta atgactcccc caatcaattg
     6181 ggttcgagcc ttgtttcttt caagctggat agtatagccg agcaattggc gacagccaaa
     6241 ggaataaaac tccgtgtgaa caccatttat gacaatatac agtatgtcac aatagatatc
     6301 aacgaagaca aaaacttaaa aataaaatca tttcattctc aataaaacaa caagaaacac
     6361 ctacacaatc aggcaaaacg agtaataatt ctgatacata aaagaaataa ggcggcgatg
     6421 tttgtgaaaa tatcgccgtc gtttttatat tataccagac actgaacggc ctgcagggta
     6481 agcatctcct tgggaaccgc cgcctgaatc tcctctttca aaacctgcag cagactggtg
     6541 cggatgaagt ctttccgggt caccaggaca atctgacggg taggccgcgg gatagcaaac
     6601 ggacggacca gttctttctg ctcttcgctc aattgcatca ctgccagttc gggaataaac
     6661 gtaatcccct taccactctc caccatatgc ataaaggttt ccatactacc cagccgatac
     6721 gccatttggc tgatcttaac cgcttccatc tgacaaaaac gaaccaactg atcgcggaag
     6781 caatgccctt cgtcaagaag ccaaagccgt tcccctgtca catcggacgt acgaatcaca
     6841 tcgtgcttga acaacggttc cttctttgag acatagccca ggaattgctc gtagaataag
     6901 gtctcttccg ttaatgcggc atcatccagc atgctggcaa tgatagcagc atccacttca
     6961 ccggtcagca gagccttgcg aatgtcgggc gtcttcagct ccatcacccg tatatcaaga
     7021 tccgggtatt tctccatcag ttgcggaaag aaacggggca gaagataagg tgcaatcgtc
     7081 ggtaacactg ccaatcggaa tgtacccgac agggagtgct gttcttcgct gatgatctcc
     7141 ttgacacaga taacttccga aagaatctta cgggcctgtt ccagcacttt cttaccaatg
     7201 gcagtagggc aaaccggtgt catgctacgg tcgaacagtt tcacccccaa ttcgtcttcc
     7261 agcttttgga tcattgcact caaagtaggt tgcgtcaccc ggcaatactc ggcagcttta
     7321 gcaaaatgcc ggaactggtc cacagccaga atatattcca attgttgtat agtcatcgtt
     7381 ctctgattta ttaaagatat agaatctatc aatgcaaaga tagaaatttt cagtttgaca
     7441 cgaatcattt tgtgccgtat ctttgttcca gataaaaaga agaaatatag tattaactca
     7501 aaaaaaacaa tatcattatg aagactttaa attatacaca tttggaagaa aaaggagcta
     7561 acaccatcgt actgtcatta cagcaactgc ttgccgattt tcagattcat tatgcaaacc
     7621 tgagaggatt tcactggaac atcaaaggac acggtttctt cgtactgcac agcaagtttg
     7681 aagatttata taatggagcc gccgaaaagg tggacgaaat agccgaacgt atactgatgc
     7741 tgggaggaac tcccgccaat agatacagtg actatctgaa gatggcgcag atcaaggaag
     7801 tggacggagt gaataaggcc gacgacgctc tgaatcatat tctcgaaact tacgggcatc
     7861 tgattgcgga agaacgtaaa atcctgtctc tcgcctcttc acacaacgac gaagtaacag
     7921 tggccatgat gagcgactac ctgaaagaac aggaaaagat ggtttggatg ctgactgcat
     7981 acaacggata acagccgaaa gggtgtagcc atacaagcaa aagggtgtag ccatcccggc
     8041 gggatagcta caccctttct gttttattcg attcagatga tacttgtacg tttggtaaat
     8101 tcaataattt ccggaatgta tccgaatgcg agcccggtca ctgtatccgc acacccataa
     8161 tagatggcaa tccgtccggt ctccgaatca tgaagcgctg cgcatgggaa acagacatta
     8221 ggcacatcac ccatacattc gtaatccttc tgaggtgaaa tcagataagg ccccgaacgg
     8281 aattttactt tccagggctg atcgatgtca agcagtgccg aaccaaaact atacacaaaa
     8341 ccgttgcagg aagccaatac accatgatag atcagtaacc agccttccga ggtttcaatc
     8401 gggataggcc ctgcaccgat cttggtacac tgccaggcac tgtcttcgaa cggagccggc
     8461 gacataacat gacgatgacg tccccagaac tccatatcgg gagactcgct atagaaaata
     8521 tctccaaaag gagtatgccc attatcactc gggcggctca acatcgcaaa acgaccgttt
     8581 atcttacgag ggaacaagac tccattccga ttgaaaggaa taaaggcatt ctccaactgg
     8641 tgaaaagtaa caaaatcata ggtgtaggcc acaccgatag taggaccatg atagccatta
     8701 caccaggtca catagtagcg gtcttcgata aagcaaaccc gtgggtcata tccatagacc
     8761 caggttccaa cctcagcatc atcacattga aactttaacg gttcttcgtt gatatcccaa
     8821 tgaacagcat ccttgctgaa tcccacatgc aaacgcatgc gacgattagt atcatcacaa
     8881 cggaacaccc ctgcatagcc atccttaaac ggaactacgg cactgttgaa tatactgttt
     8941 gaagtaggga gcaagtcgcg cggaataatc ggattggccg aacaacgcca cactacatct
     9001 ttacatcctg ccggacgttc ttcccaaggc atagccggca aagcagcacc tgcaatttta
     9061 atttcttcca tgattcgatt aaattaatat tatgtatata tcttgtttat attgaaaatc
     9121 tctttttatt tcttctttcc gtccggatat gtgaaaggta ccagccaagt cacgataaaa
     9181 gccggtatgg tagcgataag tacccagata aagaaatcgc gataacccag ccaatcgctc
     9241 aggtatccgc tcatcattcc gggaagcatc acgcccagat tcataatacc ggtagcaaaa
     9301 gcataatgtg ccatctgatg tttgccggga gccacttgct gcatcataaa gagcatcaat
     9361 ccgacaaaac caaacccgta acccaagtat tcagacacaa tggccatacc aataatccat
     9421 agatcggaag gctggtaaag ggctaacagg aaatatacca agaacggaat attaaaagcg
     9481 caacataaag aaaacaaagt cttccgaagt ccgaaagccg aaatgtaata accggccaaa
     9541 agcgaaccga gaataaaagc tcccgctccg aacgtaccat ataccagtcc gatatcctga
     9601 gtgctgagtc ccaatccacc atccgcaacc gacgctttca ggaacaacgg tacaatcttg
     9661 atggcatatc cttcggcaaa ccggtacaaa atgataaaga caatgtagaa agcaatatgt
     9721 tttttttgga aaaaagagcg gatgacttcc caaagcatat tcaatgcgtc actcatcgta
     9781 ttcacttcac cggaagcgcc tcctcccgaa ggcaaaatcc ggatgtggta aagaccgatc
     9841 agaatcataa tacccgcaca catcaacatg acaatcatcc aggcatgtac cactccaaat
     9901 tcatccttca gcatacctgc caaccaaacc aagcctccgt tggcaagtat cttggccaga
     9961 ttataaaaag ctccctgcca accgatatac ttggcttgct gggtagcagt cagttcagtc
    10021 aggtatactc cgtcccccgc aatgtcatga gtcgcaccac tgagagcaat gatccccatc
    10081 agagcgatgg cataacgaaa aaagtcgggc agcggcagcg aaagtgctac caatgcaaat
    10141 gccagtccgg taataatttc cgtagcgaca acaaagtact ttttcgtttt aaacatttcc
    10201 agaaacggac tccataaagg cttcaatgtc cagggaagca taatgagaga agtccagaaa
    10261 gcaatctgtg cattcgacac ttccatatcg gaaaacataa ggacagaaac catcgaaagg
    10321 gccacaaacg gcaatcccat agcaaagtaa acagtaggca cccaacatac agggcttatc
    10381 ggctttttat tcatcagtta gttttttata ataattccat cggttaacaa ttccagtaag
    10441 caaagatagg ggatattaaa aacataaccc aagattacga caagaagttg ctttcattat
    10501 ttaataatac aactcacccg ggaaaactac taacctctat cacccttttt ttattaaact
    10561 ttatcaatac gacacacgca aagaagcacc gaagactttc atccccgatg cctctcgccc
    10621 ccttatctac aatctaaaca cctctattgc ttcacatata aatttatctc agcaaacccg
    10681 gtataattat ccggagtcag acagtttatt ctgaattcct ttacattcgg gataggtggt
    10741 tcgatggccg catattgcgg atcagcccct ttaaaatttc tgaaagtcaa gactctcggg
    10801 taagtaaccc actcggtttc accctctttc cgaaccttaa tctcagcact tctcagatta
    10861 taacccgatc cgtaggcact ctgtttagtg accgaaaatc cggttaaggt aacaggccgg
    10921 tccagtaccg tattccacca acactctccg gcattagcca ctccccatgt aaaccaagta
    10981 gtatttatct caccgtcaat agccagatgt gcaccatatt tggcatcatc atcggcataa
    11041 acattgctgc aacttacact ccacgcactt cgatctacag cggaccaatt cccgggtttc
    11101 gtataactgg tataaagcac gctggtataa atccggatat aaaccgtctt catagatgta
    11161 ctgacagcct gttcgtccat gcccataact cctttaagcg ccacgggaag cacatatccg
    11221 tcaggattag tcaacttttc tatattcttc aaaacgacct gaaaagatga atcggccact
    11281 gtctgtcccg tttttaagac aacttcactt gtttcaatgg tataattatc ttggggcaac
    11341 aacttacatt tcgtcttatt ggcagaattg taagtatcca ctttcagcgt atctactccc
    11401 aaagcggcag tgacatcccg cgtaaccggc tgtacggcac acaattgtat ttcaaaatca
    11461 gaacggtcgg cagtagagga attgctcaca caatccacca ctaccgcagc acccatttcg
    11521 gcccccggtg caactcccgt tctgatatat atcttttgat atttgtccat ttcatcatca
    11581 tcgttgctgc acgaagccaa cgatacaaag cctgttatca ggcagattaa ggtcacaaaa
    11641 ttcaaatgtc tattcatatc ttatcttctt tttacatagt tattgcttat caaaacgaac
    11701 atgctctttc cagacaagag ttcctcctgc caccaaatcg tatccgtgtc cggtacagtc
    11761 gacaaaggca tttcccttac cttcatccat tttccaatag cctatcaggt tcggatcggc
    11821 gggcttcacg gcaaaataca tgttggactg aatttgcgtc tggctgattg cgctcttcca
    11881 aagacgcacc tgggccatct gacaattgtt gcggaagtag ctaccgctcg aaaccatgtt
    11941 catcttgtcg aatctaaccg ggccaccctt tgtctgcaga gtcacgtcga gcactccgtt
    12001 gatataaatc gacaataacc cggaagaatt ataaacgaag gccagatgat accacttatt
    12061 cttctcaaac aaagtcaccg tattgacctg acttccaagt gtcttcacct gtaatgaatt
    12121 ataagggatc atagcgtcac cgaaacggat ataaacctcg tggtcgctgc tgcccgaatt
    12181 aaatatagcc tgattattaa tatcgaatcc gtccatctgt acccaagcct cgagtgacca
    12241 ttcattggtt gtcactcccc acaattcgtc cttggcgggc ttcacggcat tggtcgtatt
    12301 cataaacggt acagactgta tcagcggctt atccagcaaa atgataaact tcgacgaaag
    12361 cccgattgtg gacaccggtc cctgaatttc tgtgagagat accggaatag catacaattc
    12421 tccgttttcg tttgaataag gtttcactct aaactcactg gggattgcgc taacatcgcc
    12481 tgccgctatc tttatctctt tgtcataagt aaaatactgc tcgggaagga cttcgtacga
    12541 agtttcatta gcttcattgt actctttaag aatagaagga tctaccgtca ggacagcagt
    12601 cacattttcg gttacaggct gtcccacacg tacggtcaga gtagttgttg ttacattttc
    12661 aggatcaacg gtaacctttg ccgaaccatt ctcggatgct tcattcaaat aaatcgcatt
    12721 gtcgataacc tggtaatcgg catcgttgca tcctgccaag atcatcggca gaacgaaaca
    12781 ggcaagcaaa tattgtttta ttgttattct tttcataatc aaattcttta aagtcatttt
    12841 acagcaggat tcattattct gattgcttca cgcaggtact tatattcgat gtcgcccgga
    12901 tagtcatatt ccatgtgata ggtgcctact ccacccttcc gtacctgttt tccgtcaata
    12961 gtcggagtcc agcgtgccat gccggcaagt gctctcattt tgtttccgta acgatctaca
    13021 taatcacctc ctcctgtcgg agcataagat tcgaaattct ccgtaacgat gtacatatta
    13081 gccactttct ccggaggaag tattccttta aagttggcaa tcgtaccagc cagacgtctg
    13141 tcaagattag catcggaatt acccgcaagg ttagagtatg cctgcacaat gaaatagtca
    13201 aagtaaggcc cggtttccgg atgaatactt tgaggctcgc catcaatcac aagtaaccgt
    13261 cccgtacccg atttaggtcc gattctttct cccagtgctt tcacgaaagt g
//
