LOCUS       gnlProkkaJBDCPNAF_1360  8442 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JBDCPNAF_1360.
ACCESSION   gnlProkkaJBDCPNAF_1360
VERSION     gnlProkkaJBDCPNAF_1360
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 11:06:21
            Original ID  :: gnl|Prokka|JBDCPNAF_1360
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 8442
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..8442
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[2336:8440]"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2337..8440
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..8442
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..8442
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     CDS             57..1580
                     /locus_tag="ctg1360_1"
                     /transl_table=11
                     /translation="MIADKSINLDTLHKVLFDNEKLELSEECIRKVEESFDFLQSFSSD
                     KIIYGINTGFGPMAQYRIEDQSLIDLQYNIIRSHSTGAGKPLPELYVKAAMIARLYTFL
                     QGKSGVHLELVSLLCEFINRGIYPFIPEHGSVGASGDLVQLAHIALTLIGEGEVFYQGK
                     LCNAATVLQENGLKPFSMRIREGLSVTNGTSVMTGIGIVNLIYAKKLLRWSVAASVMMN
                     EIAASYDDFMAQSLNEAKHHKGQQEIAAMMREWVAGSKCVLQRENELYNQVHKEKIFEH
                     KVQPYYSLRCVPQILGPIYDELENAEEVLINEINSACDNPIVDPDTQNIYHGGNFHGDY
                     ISFEMDKLKIAVTKLTMLCERQINYLFHDRINGILPPFVNLGVLGLNYGLQASQFTATS
                     TTAECQTLSNPMYVHSIPNNNDNQDIVSMGTNSALLAKTVIENSYQVMAIQFMGMAQAI
                     DYLKIQDRLSSKSRQVYEEIRSFFPVFTNDTPKYKEIEMMIDYLKKEDK"
     CDS             1582..2310
                     /NRPS_PKS="Domain: PKS_KR (3-169). E-value: 2.3e-16. Score:
                     52.1. Matches aSDomain: nrpspksdomains_ctg1360_2_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     215.6; E-value: 1.3e-65)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1360_2"
                     /sec_met_domain="adh_short (E-value: 1.7e-35, bitscore:
                     111.9, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYALVTGGSRGIGRAVSCKLAEMGYFILINYQNNDAEAEKTLQL
                     VQEKGSNGELMKFDVTDPAAITLALGNWASQHPDEYIEVLINNAGIRKDNLMLWMTGEE
                     WSKVLDISLNGFFNVTQPLLKNMLVKRYGRIVNIVSLSGIQGMPGQANYSAAKGGVIAA
                     TKALAQEVAKKKVTVNAVAPGFIRTDMTEGIDENEWKKHIPAGRFGTPEEVADLVGFLA
                     SPASSYITGEVISINGGLYT"
     aSDomain        1591..2088
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1360_2_PKS_KR.1"
                     /evalue="2.30E-16"
                     /label="ctg1360_2_PKS_KR.1"
                     /locus_tag="ctg1360_2"
                     /protein_end="169"
                     /protein_start="3"
                     /score="52.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ALVTGGSRGIGRAVSCKLAEMGYFILINYQNNDAEAEKTLQLVQE
                     KGSNGELMKFDVTDPAAITLALGNWASQHPDEYIEVLINNAGIRKDNLMLWMTGEEWSK
                     VLDISLNGFFNVTQPLLKNMLVKRYGRIVNIVSLSGIQGMPGQANYSAAKGGVIAATKA
                     LAQ"
     CDS_motif       1594..1656
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg1360_2_0001"
                     /evalue="2.90E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg1360_2"
                     /protein_end="25"
                     /protein_start="4"
                     /score="13.5"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRAVSCKLAEMG"
     CDS             2337..3560
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (65-404). E-value:
                     1.8e-53. Score: 173.8. Matches aSDomain:
                     nrpspksdomains_ctg1360_3_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 295.5; E-value:
                     1.1e-89)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1360_3"
                     /sec_met_domain="APE_KS1 (E-value: 1.7e-159, bitscore:
                     520.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRVVITGMGIYSCIGKNLDEVKDSLYNGKSGIGIDPVRKELGYF
                     SALTGILERPDLKKLLDRRKRLCLPEQGEYAYLATLEAFRNAGINEDFLEANEVGILYG
                     NDSSAAPVINAVDIIREKKNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTIAGACA
                     SGSHAIGMGYLLIKSGLQDCILCGGAQEVNPYAVGSFDGLSAFSTQEAAPEKASKPFDK
                     RRDGLIPSGGAASLVLESYESAVKRGAPILAEVIGYGFSSNGDHISVPNVDGPKRSLQM
                     AIKDAGIALEQISYINAHATSTPVGDLNEAKAIAEVFEGHHPYVTSTKSMTGHEMWMAG
                     ASEVIYSTLMMNNGFIAPNLNFEEPDEASAQLNIPTQRVNLEFDTFLSNSFGFGGTNST
                     LIIRKINP"
     aSDomain        2532..3548
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1360_3_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.80E-53"
                     /label="ctg1360_3_PKS_KS.1"
                     /locus_tag="ctg1360_3"
                     /protein_end="404"
                     /protein_start="65"
                     /score="173.8"
                     /tool="antismash"
                     /translation="RLCLPEQGEYAYLATLEAFRNAGINEDFLEANEVGILYGNDSSAA
                     PVINAVDIIREKKNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTIAGACASGSHAI
                     GMGYLLIKSGLQDCILCGGAQEVNPYAVGSFDGLSAFSTQEAAPEKASKPFDKRRDGLI
                     PSGGAASLVLESYESAVKRGAPILAEVIGYGFSSNGDHISVPNVDGPKRSLQMAIKDAG
                     IALEQISYINAHATSTPVGDLNEAKAIAEVFEGHHPYVTSTKSMTGHEMWMAGASEVIY
                     STLMMNNGFIAPNLNFEEPDEASAQLNIPTQRVNLEFDTFLSNSFGFGGTNSTLIIRK"
     CDS             3582..3833
                     /NRPS_PKS="Domain: PP-binding (7-75). E-value: 3.8e-14.
                     Score: 44.9. Matches aSDomain:
                     nrpspksdomains_ctg1360_4_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1360_4"
                     /sec_met_domain="PP-binding (E-value: 6.1e-15, bitscore:
                     44.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNEEIIEKIRTTLAEEFEVDIDVIQPDAPLMETLELDSLDLVDM
                     VVLVEKNFGFNVTGQDFAGIKTFQDFYDLVITRMQEAK"
     aSDomain        3603..3806
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1360_4_PP-binding.1"
                     /evalue="3.80E-14"
                     /label="ctg1360_4_PP-binding.1"
                     /locus_tag="ctg1360_4"
                     /protein_end="75"
                     /protein_start="7"
                     /score="44.9"
                     /tool="antismash"
                     /translation="EKIRTTLAEEFEVDIDVIQPDAPLMETLELDSLDLVDMVVLVEKN
                     FGFNVTGQDFAGIKTFQDFYDLV"
     CDS             3836..4753
                     /locus_tag="ctg1360_5"
                     /transl_table=11
                     /translation="MSTWKGKTRGGTFGYLFFIYLIKYLGITAAYIFLSLVVLYFVPFA
                     PKATKSTWFYARHILKYNRIRSLGMLLRNYYRLGQILIDKVAIGNGKVDQYRFEFERYP
                     EFLQLLNSEQGVIMIGAHVGNWEIGVPFFDDYGKKINIVMYDAEHRRIKEILEKNGQDK
                     DFKIIPVNEDNLTHVFRITEALNKKEYVCFQGDRYLNKEKLLTGTLLGQKAPFPAGPFL
                     LGSRMKVPVVFYFAMREPGRTYRFHFIRTEPVIRTKEKKAEIALLEQYTAALDQILKRH
                     PEQWFNYYSFWKTTSDGSPSKGLK"
     CDS             4772..5842
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 124.5; E-value:
                     9.1e-38)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1360_6"
                     /transl_table=11
                     /translation="MQQNQYDKEPLTAVEAQRLAQEIAFGPIVFQVSRLMLKFGIFQLL
                     ADERAGMTQEEISKACGLSSYATQVLLEASLTIGTVLRHENLYRLAKAGWFLLNDRMVR
                     VNMDFNHDVNYLGMFHLEEALTNGRPGGLKVFGEWSTIYEGLSSLPSQVQKSWFGFDHY
                     YSDCSFDEALAIVFARHPKTLLDVGGNTGRWATKCVSYDDAVEVTIMDLPQQLEMMRQQ
                     TKDLPGAMRIHGYGANLLDPEVPFPTGFDAIWMSQFLDCFSEEEVTSILTRAARSMSGE
                     SRLYIMETFWNRQKFDTAAYCLTQISLYFTAMANGNSKMYHSDDMERCIKAAGLEVEKI
                     DDHLGMGHSIVQCRLK"
     CDS             5839..6276
                     /locus_tag="ctg1360_7"
                     /transl_table=11
                     /translation="MNNREVIIQGEGILNLIPQRPPIVMVDSFFGIEKNHSYSGLTVTA
                     DNIFYETGKLQEAGIIEHIAQSAAARIGFLYTRQGEKVPLGFIGSVDKLKIYDLPKNGM
                     KLFTEITVVQEVFDITLISAQVKVEDKLIAECRMKIFIKKE"
     CDS             6273..6716
                     /locus_tag="ctg1360_8"
                     /transl_table=11
                     /translation="MKRKTNQQVAALTNRTTFRVRFSEIDSMQIVWHGEYVRYFEDGRE
                     AFGKQYGLDYMSIYREGYMVPIVDLTCQFKQSLSFGEEAIVETRYIACEAAKIKFEYII
                     YRATDQSIVATGSTIQVFLNLNKELELMNPPFYLEWKKKWNIL"
     CDS             6701..8440
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (125-376). E-value:
                     6.8e-28. Score: 89.5. Matches aSDomain:
                     nrpspksdomains_ctg1360_9_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 174; E-value:
                     8.7e-53)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1360_9"
                     /sec_met_domain="APE_KS2 (E-value: 1.5e-108, bitscore:
                     352.5, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYPLNIYITAHTLISSLGFGIPENLEAIHNYRSGIRMQEAGLIS
                     DHPLLAGMIDSVELEKRAKLMQITDYTRMEQLFILAIQEVISQSGADLREPDCTLLLST
                     TKGNIDLLSELPADSPVFLWKMAERIGDFFGATNQVEVISNACISGVSALIVAKRWIES
                     GRYKRVIVAGGDILSHFITSGFLSFRSVSAHLCRPYDIQRDGLSLGEACGAVLLETQGN
                     ANHIILSGGAISNDANHISGPSRTGDGLALAINQAMEEAGALPEDISFINAHGTATVYN
                     DEMESKAIHLAGLAAVPVNSLKPYFGHTLGASGIIETILCIEQLKEGRYYGTLGYETLG
                     VPMPITVYTTHQPMPMKCCIKTASGFGGCNAALVLSLPDAHLKQKVNLQATDKASAPSV
                     CKAVVESGNMVTIRPGAVESKGTTVFSSSETDFAPFIREAYKHLGENNMKFYKMDNLCK
                     LGYVAAEYLLKNTHHRPEEIGIILANASSSLDTDCKHQAIISKEGDKAASPAVFVYTLP
                     NVVLGEICIRHKIQGENTFFVRRQSDAASLEDYARIVMAKGKLRTCIIGWCELLDGHYQ
                     AEFK"
     aSDomain        7076..7828
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1360_9_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="6.80E-28"
                     /label="ctg1360_9_PKS_KS.1"
                     /locus_tag="ctg1360_9"
                     /protein_end="376"
                     /protein_start="125"
                     /score="89.5"
                     /tool="antismash"
                     /translation="MAERIGDFFGATNQVEVISNACISGVSALIVAKRWIESGRYKRVI
                     VAGGDILSHFITSGFLSFRSVSAHLCRPYDIQRDGLSLGEACGAVLLETQGNANHIILS
                     GGAISNDANHISGPSRTGDGLALAINQAMEEAGALPEDISFINAHGTATVYNDEMESKA
                     IHLAGLAAVPVNSLKPYFGHTLGASGIIETILCIEQLKEGRYYGTLGYETLGVPMPITV
                     YTTHQPMPMKCCIKTASGFGGCNAALVLS"
ORIGIN
        1 agaaattgcc tatttttgca ccttattatt aaggcataaa atatctagta cagaaaatga
       61 tagctgacaa aagtataaat ttagataccc ttcataaagt attgtttgat aatgagaagc
      121 tggaactctc tgaagaatgt attcgaaaag tagaggaaag cttcgatttt ctgcaatcct
      181 tttccagcga taagattatt tatggtatca atacggggtt cggcccaatg gcacaataca
      241 gaatagaaga tcagtcattg atcgaccttc agtataatat catccgaagc cattccaccg
      301 gtgccggcaa accgcttccc gaactttatg taaaagcagc tatgattgcc cgtttgtaca
      361 cttttctaca agggaagtca ggagtgcatc tggaactggt ttctctcctc tgtgaattta
      421 tcaaccgcgg aatttatccg ttcatacccg aacacggaag tgtaggtgcc agcggcgatc
      481 tcgtacaact ggcccatatc gccctgacgt taatagggga aggggaagtt ttttatcagg
      541 gtaaattgtg taacgcagct acggtgcttc aggaaaacgg cctgaaacct ttttccatgc
      601 gtattcgtga aggtttatcc gttacaaacg gtacttctgt aatgacaggc atcggtattg
      661 tcaatctgat ttatgcaaaa aaactactcc gttggtcggt ggctgcctct gtaatgatga
      721 atgagattgc cgcctcttat gatgatttta tggcacagtc attaaacgag gccaagcatc
      781 ataaaggtca acaagagata gctgctatga tgagagaatg ggtggcaggc agtaaatgcg
      841 tgcttcaaag agagaacgag ctatacaacc aggtgcataa agagaaaatc ttcgaacaca
      901 aagtacagcc ctattattcc ttgcgatgtg ttccgcaaat actcggtcct atttacgatg
      961 aactggagaa tgcggaagaa gtattaataa acgaaataaa ttccgcctgt gacaatccga
     1021 ttgtcgatcc ggatacacaa aatatttatc atggcggcaa cttccacgga gattacattt
     1081 ctttcgaaat ggacaagttg aaaattgccg tgaccaagct gactatgctt tgcgaaagac
     1141 agattaacta tctgttccac gaccgtatca atggcatcct gcctccgttt gtaaatttgg
     1201 gagtgcttgg attgaactat ggtttacagg cttcacaatt cactgcaacc tccaccacag
     1261 cggaatgtca gacattatca aatccgatgt atgtacacag tatccccaac aacaatgata
     1321 atcaggatat tgtcagcatg ggaaccaact cggctctatt agcaaaaaca gtcattgaga
     1381 attcttatca ggtgatggct atccagttta tgggaatggc acaagctatc gactacctga
     1441 aaatacagga tcgcctaagt tccaaaagca ggcaggttta tgaagaaata cgcagtttct
     1501 tccctgtatt taccaatgac acacctaaat ataaagagat agaaatgatg atagactatc
     1561 tcaaaaaaga agataaataa aatgaaatat gcattagtaa ccggaggaag ccgaggtatc
     1621 ggccgtgctg tcagttgtaa actggcggaa atgggctact ttatactgat aaattatcag
     1681 aataatgacg cagaagcgga gaaaacgttg cagttagtac aggaaaaagg aagtaatggc
     1741 gagttgatga agttcgatgt gaccgaccct gccgctatca cccttgcttt gggcaactgg
     1801 gcttcccaac accctgacga atatatcgag gtactgataa acaatgcagg tatccgcaaa
     1861 gacaacctga tgctctggat gacaggagaa gaatggagca aagtgctcga tatcagcctg
     1921 aacggattct tcaacgtgac acagccttta ttgaagaata tgctggtcaa acgttatgga
     1981 cgtatcgtaa atatcgtgtc attgtcgggc attcagggaa tgcccggcca agccaattac
     2041 tccgcagcca aaggtggcgt aatagctgct accaaagcac tggcacagga agttgccaag
     2101 aagaaagtaa cagtcaatgc agtagctccg ggattcatcc gtacggatat gacggaagga
     2161 attgatgaga acgaatggaa gaaacatatt cccgcgggac gtttcggcac tccggaagag
     2221 gttgccgacc tggtcggttt cctggcatct ccagcctcat cctacatcac aggagaagtg
     2281 atttccatca acggaggact atatacttaa aataaaagca tagaatagac aaaataatga
     2341 aaagagttgt tatcacggga atggggattt actcttgcat cggcaagaat ctggatgaag
     2401 taaaagactc actatataat gggaaatcgg gaattggcat agacccggta cggaaagaat
     2461 tgggttactt ttctgcatta acggggatat tggaacgtcc cgacttgaag aagttgttgg
     2521 accgccgtaa acgtctctgt ctaccggagc agggagaata tgcttatctc gctacattag
     2581 aagctttccg taatgccggt attaatgagg attttctcga agccaatgaa gtgggtattt
     2641 tgtatggcaa tgatagtagt gccgctcctg ttattaatgc agtggacatc attcgtgaaa
     2701 agaaaaacac tgcactggta ggttccggtt ctattttcca gtcgatgaat tccaccgtga
     2761 caatgaacct gtcagttatt ttcaaactaa gaggggtcaa cttcaccatt gccggagcct
     2821 gtgcaagcgg ttctcacgct attggtatgg gttacctgct tataaaatcg ggattacagg
     2881 attgtattct ttgcggtggc gcacaagaag tcaatcctta tgcagtagga agtttcgacg
     2941 gactaagcgc attttccacc caggaagcag cccccgagaa agcctcgaaa ccttttgata
     3001 aacgacgtga cggactgatt ccgagtggag gagccgccag tctggtatta gagagttatg
     3061 aatcggctgt aaaaagagga gctcccattt tggccgaagt catcggttac ggtttttcat
     3121 ccaatggaga tcacatctcc gtgcctaatg tggacggccc gaaacgttct cttcaaatgg
     3181 ccatcaaaga tgcagggatt gcactcgaac agatcagcta tatcaatgca cacgccacct
     3241 caactccggt aggtgacttg aacgaagcga aagccattgc ggaagtattt gaagggcatc
     3301 acccatatgt gacctccaca aagtccatga caggacatga aatgtggatg gccggtgcca
     3361 gtgaagtgat ttattccacc ctcatgatga acaacggttt catcgctccc aatctcaatt
     3421 tcgaggaacc ggacgaggcc tctgcacaat taaatatacc tacccaacgg gtaaacctgg
     3481 aatttgatac gttcctttcc aactcattcg gattcggagg aaccaattcc acgctaatca
     3541 tacgcaaaat caatccataa tttactaaag aaaacagata tatgacaaac gaagaaatca
     3601 tcgagaaaat aagaaccact ctggcagaag agtttgaagt agacatcgac gtcatccagc
     3661 cggatgcacc gttaatggaa actcttgaac tggacagcct ggacttggtc gatatggtgg
     3721 tactggtaga aaagaacttc ggcttcaacg taaccggaca agattttgcg ggtatcaaaa
     3781 ccttccagga cttctacgat ctcgttatca cccgtatgca ggaagccaag taaatatgtc
     3841 gacgtggaaa ggcaaaaccc ggggaggaac attcggatac ttattcttta tttacctgat
     3901 taagtatctg ggcattactg ccgcttatat atttctaagt ctggtagtat tgtacttcgt
     3961 accgtttgct ccgaaagcca ctaaaagcac ctggttttat gcccgccaca ttctgaaata
     4021 caaccgaata cgctctttgg gtatgttgct gcgcaactat taccggttag ggcaaatcct
     4081 gattgacaaa gtagctattg gtaacggaaa agtcgatcaa taccggtttg agttcgaacg
     4141 gtatccggaa tttctgcaat tgctgaacag cgaacaggga gtaattatga ttggtgccca
     4201 tgtgggaaac tgggaaatag gcgttccttt cttcgacgat tacggaaaga aaatcaatat
     4261 cgtgatgtat gatgccgaac atcgtagaat caaagagata ttggagaaaa atggtcagga
     4321 caaggatttt aagattatcc ccgtcaacga agataacctg acacacgttt tccgtattac
     4381 cgaggcgtta aacaagaaag aatatgtatg cttccagggc gaccgttatc tgaataaaga
     4441 gaaactgctg acaggaacac tcctgggaca gaaagctcct ttccctgccg gtcctttctt
     4501 gcttggttcg cgaatgaaag ttccggtggt attctacttt gccatgagag agccgggcag
     4561 aacctaccgt tttcatttta taaggacgga accagtcata cgaaccaaag aaaagaaagc
     4621 agagatcgct ctgctcgaac aatatacggc cgctttggac caaatactga aacgccatcc
     4681 ggaacaatgg ttcaactatt actcattctg gaaaaccacg agtgacggtt cgccctccaa
     4741 aggattgaaa taaagatata acaaaataaa gatgcaacag aatcaatatg ataaggaacc
     4801 gttgaccgcg gtagaggcac aacgcttggc acaagaaata gctttcgggc ccatcgtgtt
     4861 tcaggtatca cgccttatgc tcaaattcgg tattttccag ttactagccg acgaacgtgc
     4921 aggcatgaca caagaagaaa tcagcaaggc ttgtggcctg tcttcttatg caacacaagt
     4981 tttgctggaa gcctcattaa cgatcggtac cgtattgcgg cacgaaaacc tttaccgcct
     5041 tgccaaagcc ggatggttcc tgctcaacga caggatggta cgtgtcaata tggatttcaa
     5101 ccacgatgtc aactatctgg gaatgttcca tctcgaagag gctctcacca acggacgtcc
     5161 cggagggctg aaagtattcg gcgaatggag cactatctat gaagggctgt caagcttgcc
     5221 ctcacaggta caaaagagct ggttcggttt cgatcattat tactcggatt gctcgtttga
     5281 cgaagctttg gcaattgttt tcgcccgtca tcccaagact ttactggatg tgggaggtaa
     5341 taccggtcga tgggcgacca aatgcgtaag ctatgacgat gcagtggaag taactattat
     5401 ggaccttccg caacaattgg agatgatgcg tcaacaaact aaagacctac ccggagcaat
     5461 gcgtattcac gggtatggcg ccaatctgct cgatcccgaa gtacctttcc cgacagggtt
     5521 cgatgctatc tggatgagcc agttccttga ttgtttctcg gaagaagaag taaccagcat
     5581 actgacccgt gcagcccgtt ctatgagtgg ggagagtcgc ctctatatca tggaaacttt
     5641 ctggaaccgg caaaagtttg acacagccgc ttattgcctg acacaaatca gtctttattt
     5701 cacagccatg gcaaatggta acagcaaaat gtatcattcg gatgatatgg aacggtgcat
     5761 caaagcagcg ggattggaag ttgaaaagat agatgaccat ttaggaatgg gacacagcat
     5821 tgtacaatgc agattgaaat gaacaacagg gaagttatca tacaaggaga aggaatactc
     5881 aatttgattc cacagcgtcc gcccatcgtg atggtggaca gtttctttgg tatcgaaaag
     5941 aatcattctt attccggact gactgttact gctgataata ttttctacga aaccggaaaa
     6001 ctgcaagagg caggaattat tgaacacatc gctcaatcag cagcggcacg tatcggattt
     6061 ctttataccc ggcagggtga aaaagtaccg ttagggttta tcggctcggt agacaaactt
     6121 aaaatctacg atttgccaaa gaacgggatg aaactattta cggagattac cgttgtacag
     6181 gaggtattcg acattacatt gatttctgca caagtgaaag tggaagacaa gctgatagct
     6241 gaatgcagga tgaaaatatt tataaaaaaa gaatgaaacg gaaaacgaat caacaggttg
     6301 cagctttgac taaccggact accttcagag tgcggttcag cgaaatagac tccatgcaga
     6361 ttgtatggca tggtgagtat gtgcgctatt ttgaagatgg aagagaagct tttggcaaac
     6421 agtatggttt ggattatatg agtatttacc gggagggata catggttcct atcgtggatt
     6481 taacctgtca gttcaaacaa tcactatctt ttggtgaaga agcgattgtc gaaacgcgct
     6541 atattgcctg tgaagcagcc aagataaaat ttgaatacat tatctaccgg gctaccgacc
     6601 agagtatagt agccaccgga agcaccatac aagtgttcct gaacctgaat aaagaattgg
     6661 agcttatgaa tcctccgttt tatctggaat ggaaaaagaa atggaatatc ctttaaatat
     6721 atacatcaca gcccatacgc tgattagttc gttaggtttc ggcatcccgg aaaacctgga
     6781 ggccatccat aactaccgaa gcggaatccg tatgcaagaa gccggcctaa tttccgatca
     6841 tcccctattg gcgggaatga ttgattctgt ggaattggaa aaacgggcga agctgatgca
     6901 gattacggat tatacccgaa tggagcaatt attcatactg gctatccaag aggttatttc
     6961 tcaatcggga gccgacttgc gggagccgga ttgtaccttg ttattatcta ccactaaagg
     7021 aaatatagat ttattgagtg aattacctgc tgacagtccg gtttttcttt ggaaaatggc
     7081 ggaacgaatc ggagatttct ttggagcgac aaatcaggta gaggtcatct ccaatgcctg
     7141 tatatcagga gtctcggcac taatcgtcgc taagagatgg atagaatcag gacgttacaa
     7201 acgagtgatt gtggcaggtg gggatattct ttctcatttc attaccagcg gctttctatc
     7261 gtttcgatct gtcagcgcac acctttgccg accatacgat atacaacggg atggattaag
     7321 tctgggcgaa gcctgtggag ctgttctttt agaaactcaa ggaaacgcga atcatattat
     7381 tctctccgga ggagcaatca gcaatgacgc caaccatata tccggtcctt cccgaacagg
     7441 ggacggttta gctctagcca ttaatcaggc aatggaagaa gccggagcac tccccgaaga
     7501 cattagcttt atcaatgcac acggaacagc tacggtttac aatgatgaaa tggaatccaa
     7561 agccatacat ctggcgggat tagctgcagt tccggtgaat agcctcaagc cctatttcgg
     7621 tcatacatta ggagcttcgg gcattatcga aaccatactt tgcatagagc aactaaaaga
     7681 aggaagatac tacggaactt tagggtatga aacactcggt gttcccatgc ctatcactgt
     7741 ctataccact catcagccga tgccgatgaa atgctgcatc aaaaccgctt ccggtttcgg
     7801 aggctgtaat gccgcactgg tattatccct ccccgatgct cacctgaaac agaaagtaaa
     7861 cttgcaggca accgacaaag cgagtgctcc gtcagtttgc aaagcagtgg tggaatcggg
     7921 caacatggtc acaatcaggc caggagcagt agaaagtaaa ggaacaactg tattcagctc
     7981 ttcggaaact gactttgcac cgttcatccg ggaagcatac aagcatctgg gagaaaacaa
     8041 tatgaagttc tataagatgg acaacctctg taagctggga tatgtagctg ccgaatattt
     8101 actgaaaaat acacaccacc gtccggaaga gattggaatc attcttgcca atgcttcttc
     8161 ctctctggat acggactgca aacatcaggc aatcatcagt aaagaagggg acaaagcagc
     8221 cagtcctgcc gtgtttgtct acactctccc caatgtagta ttgggagaaa tctgtatccg
     8281 gcacaagatt cagggagaga atacattctt tgtccgtcgg caatccgatg ctgcctcatt
     8341 agaggattat gcaaggattg tgatggcaaa aggtaagtta cgcacctgta tcataggctg
     8401 gtgcgaacta ctggacggac attatcaagc agaatttaaa ca
//
