LOCUS       c00137_gnlPro..        13800 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LFCFAIKE_137.
ACCESSION   c00137_gnlPro..
VERSION     c00137_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 13:08:03
            Original ID  :: gnl|Prokka|LFCFAIKE_137
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13800
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13800
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:3800]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3..3800
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..13800
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13800
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(3..359)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg137_1"
                     /sec_met_domain="OAD_beta (E-value: 3.8e-24, bitscore:
                     76.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGSVLLQAAGTAHESFLQFLGENLELFLTYTGVYNATPGHLIMI
                     LVGLLFIFLAIKYEFEPMLLIPIGFGILIGNIPFKDAGLQVGIYEQGSVLNILYQGVTS
                     GWYPPLIFLGIGAMT"
     CDS             complement(364..795)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 65.5; E-value:
                     9.6e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg137_2"
                     /sec_met_domain="Biotin_lipoyl (E-value: 4.3e-21, bitscore:
                     65.5, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFKYTINGNVYKVHISSVVDDIAEVEVNGTPYQVKMEKPAKKQ
                     MVTLKRPAQAPTTASGEPVISRPAASTTKGAVKSPLPGVILQVNCKVGDTVKRGQNLLV
                     LEAMKMENNINADRDGKIIEIKVNKGDSVLEGADLVVIG"
     CDS             complement(818..1711)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg137_3"
                     /sec_met_domain="OAD_gamma (E-value: 2.3e-12, bitscore:
                     38.3, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNMINKKIGVLLLFALLVSFGAKAQRATSMRINEVLVINEDNFVD
                     DYGKRHAWIELFNNSAGSVNIAGCYLTNDKSNPKKYPIPKGDVLTVIPPRQHTLFWADG
                     EPDRGTFHVNFTLDPSKENYIALYDADGKTLIDEIVIPASQKADVSYGRTLDGQGEWTA
                     LTKVTPSTNNVTLDSNEKIENFKENDSWGIGMTLTAMAVVFSGLFLLFIIFKQIGKLSI
                     AASKRNAQKAAGAAVIADNAGQESGEIFAAIGAALYEMSDDNHDIEHTVLTIRKVQRSY
                     SPWSSKIYGLREVPKK"
     CDS             complement(1727..3280)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg137_4"
                     /sec_met_domain="CT_Btheta (E-value: 3.3e-292, bitscore:
                     960.0, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIALRETARLGGGEKRIESQHKKGKYTARERIAML
                     LDEGSFEEFDMFVQHRCTNFGIEKTKYLGDGIVTGYGTIDGRLVYIYAQDFTVFGGALS
                     EALAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTT
                     KSGVAHFAVDTEEDGLQLIRKLISFLPQNNLEETPLIECKDPIDRLDDNLNDIIPDNPN
                     QAYDMYEVIGTIIDNGEFLEVHADYAKNIIVGFARFNGQTVGIVANQPKVMAGCLDSNA
                     SRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTV
                     TLRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAASEDPKACAA
                     EKEAEYKKAFANPYNAAQYGYIDDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
                     "
     CDS             complement(3393..3800)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg137_5"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.8e-27, bitscore:
                     86.7, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELTHIEHLGIAVKSIEACLPYYEEVLGLKCYNIEEVADQKVKTA
                     FFKVGQTKIELLEPTSEDSTIAKFIEKKGEGIHHIAFAVPDVQAALDEAESKGIKLIDK
                     APRGGAEGLNIAFLHPKSTCSVLTELCMPGK"
     CDS             complement(3945..6350)
                     /locus_tag="ctg137_6"
                     /transl_table=11
                     /translation="MKIRAIATLLFILFSISAFGQGRAKISGYIRDADGNPLDLVNIRV
                     KNTLNGTMSNEKGHYSLSVATGDSVTLIYSCLGYNKAERILPQVTKDMRLNVQMNYTSL
                     ELGEVVATAIRKQTTTLETLNADRVKLLPDPAGGSIESLVVTFAGVTSNNELSSQYSVR
                     GGSYDENIVYVNGLEVFRPLLIRSGQQEGLSFINPDMTEAVNFSAGGFEARYGDKMSSV
                     LDITYKKPKGFEGSASASLLGANAYVGSSSGKFTQVTGFRYKTGRSLLKTTDTDAEYDP
                     NFIDLQTYMTYQLAPKWEINFLGNLAINNYKFIPHTRETSFGTATNAKKFKVFMSGQER
                     DKFETLFGALTLKHNLNDNTELGLQASAFTSKEEEGYDIAGDYWLGDAAEEGGGEIQNL
                     SIARYNEHARNRLHSNIMNVGHYGVARIKNNTLKWGATVQLEKINDKISEWEKRDSAGY
                     SLPQGGGNVNVIANLFSDNKLESTRISGYLQDVFKFRTKQGLFTLVGGVRGSYWSYNRE
                     FIFSPRASIGFIPNFDQNLTFRLASGLYYQSPFYKELRTTVQDEHGNSIIQLNKNLKSQ
                     RSIHVIAGGDYTFRASGRNFKVSADMYYKKLDNLNPYTVDNVKIRYYGENCAQGHAMGL
                     DVKFFGEFVPGTDSWISFSLMKAEQSIRGSEYVPMPNSQGYNVSLFFQDYFPGYKRVKL
                     NLKGVLSGGLPVTAPRTGYEDGYFRTPTYKRVDLGFSYQLAGGTDAIMDRGFFRNLKNI
                     WLGLDIFNLFDIKNTSSYYWITNIDNHQYAIPNYLTGRQLNIRLIVDF"
     CDS             6666..7391
                     /locus_tag="ctg137_7"
                     /transl_table=11
                     /translation="MKIKGHTPKNTPIEHMKEFYKDFDEMQDDFYDGMIITGAPVEQMP
                     FEEVNYWEEVTEIFDWARTHVTSTLYICWAAQAGLYHFYGVPKYDLPAKMFGVFRHTLR
                     EPYVPIFRGFDDEFYVPHSRHTEIRREDVMKVPDLTLLSESEESGVYMAMARGGREFFI
                     TGHSEYSPYTLNDEYMRDVNKGLPIAVPRNYYRNNNPALGPVVRWRGHANLLFTNWLNY
                     YVYQETPFRIEDISKLGDL"
     CDS             7414..9243
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_U32"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg137_8"
                     /sec_met_domain="Peptidase_U32 (E-value: 1.4e-73, bitscore:
                     237.7, seeds: 96, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQTKSRPIELLSPAKDLNCGIEAINHGADAVYIGAPKFGARSAAG
                     NSLEDIRELCGYAHLYGARIYVTLNTILKEDELEEAERMIWDLWRVGTDALIIQDMGIT
                     RLNLPPIPLHASTQTDNRTPEKVRFLEAAGFTQVVLARELSLNEIRRISEATTVPLEVF
                     VHGALCVSYSGQCYLSAALSGRSANRGECAQYCRLPYTMVDATGTEIVTHKHLLSLKDM
                     NRSDQLEALLDAGVSSLKIEGRLKDVGYVKNITAYYRKKLDAVLSRRPEYRRASAGRST
                     YTFEPVAEKSFNRGFTPFLLEGRTADITAFNTPKSLGEPVGTVKEIKGNSFTVAGLKQL
                     NNGDGLVFFNRKGELEGFRVNRVEANRVFPLDMPQLAPKTPLYRNFDQAFDKLLAKPSA
                     ERKLSVEIEFLDNPFGFTLCMEDETGARIMLTEPFAKELARREQQDNIRTQLSKLGNTP
                     FEASKVVVGLSENWFVPSSLLADMRRRGVEKLLEARRARYPRETVKRVQPSVSIPFPER
                     QLTYLGNVANGKARSFYQDHGVEQIDPAFELSPRKDVPLMFTKHCLRYSMGWCPTYQKD
                     KSPYKEPYYLLYKDTRLRLQFDCKHCQMLVFES"
     CDS             complement(9461..9928)
                     /locus_tag="ctg137_9"
                     /transl_table=11
                     /translation="MKIINEALLDETTGRAKQSPRLRMNYNFHEHLDDPVNRLLNALEP
                     GTYLRPHRHLNPKKDEIFLLLRGRIAVFLFDNKGEITKTQILDPKEGVYGAEIKAGTWH
                     GLLVLESGSVIYEIKEGPFAPLAPENFAPWSPAPEDTKGVAKYMELLGKAI"
     CDS             10163..12757
                     /locus_tag="ctg137_10"
                     /transl_table=11
                     /translation="MLLDMKVQASEYPGVSLLVEDAADSSLLQVEQIRSLIKRKVDLLI
                     ISANESEPVTPIAIEAYRAGIPTILVDRKISSDEYTTYIGGNNYEIGRQAGFFVNRQVK
                     EKYPTVLEVWGLSGSSPAQDRHRGFMEVLNSRIKVKEIFGKWKPETVEKEIAEMDSLEE
                     VDVVFAHNDVMAMAARRAIERMHPGLADRICFVGIDAVSGRGSGLEAVMHGELAASVLY
                     PTGGSLAIRVAMQILNGEDVSRQYLLSSALIDKNNAGTLFIQSEQVVDYQHQIELQREN
                     LESMLSKYTFLQNSVGIILLLMGMLLLSALYVIHVNRAVKRKNRELKRTNLQVQQQKEE
                     LAEANRYIEKSTAQKLQFFTNITHEIKTPLTLILGPLGKLSKEAPEGSSLADDIRIIRK
                     NAERLKRVVDQLLDFRKVESNKMNMRVGEVDLVAFVAEVKSYFDTMATTKQIHFTFEHD
                     CPSVNIWVDRDKMEKILANLLSNAFKFTLDGGTVTIRLKDKGDQVELSVEDNGKGIPSE
                     NIASVFDRFFTGDQNYVTGTGIGLHLTREFVHMHKGTIRVESVPHKSTVFTVILLKGKS
                     HFDESCIFDLSVTELSSGVADLNTDELQEVLNRTYNYTVLVVEDDLDIQSYLQAELKQN
                     FRVLVADNGVKALEVLMNEEISMVISDVMMPEMNGFDLCRKIKSDIVLSHLPVMLLTAL
                     SDDKQQMYGAASGADAYIQKPFNIEVVKLRIIKLLEDRVRLREAYARDASSPAVSVKEE
                     KAGSMDDLFMNRFLKLIEESYADPDFSIEKGSEKLGLSRVHLYRKVKELAGVTPTDFLR
                     NYRLKKAAALLRRKAGNVNEVAYATGFGSPAYFSKCFKAVYNITPTEYLEKE"
     CDS             complement(12877..13254)
                     /locus_tag="ctg137_11"
                     /transl_table=11
                     /translation="MIPSYTFINNIVRDTILQSNLYRSGRIRDFLDQIPDRIIIQFFED
                     FAPQPIVSHGADSISFRPQPRRMVDKIDRSTTCFLSCWQHVPQEFSYAYYDRFLIVALH
                     CFIIVYLTRIIYYLRCKDRDR"
ORIGIN
        1 tcggtcatgg ccccgatacc gaggaagatc aacggcggat accatccgga ggttacaccc
       61 tggtagagga tgttcagcac agaaccttgt tcgtaaatac ccacctgcaa tcctgcatct
      121 ttgaacggaa tgttaccgat caggataccg aatccgatag ggataaggag cataggctcg
      181 aattcatatt taatagccag gaagatgaac aacagaccga caaggatcat gataaggtga
      241 cccggtgtcg cgttgtagac tcctgtataa gtgaggaaca actccaagtt ttctcccaag
      301 aactggagaa agctttcatg agccgtaccc gctgcctgta ataatactga tcctaacata
      361 atattatcct attacgacga ggtcagcacc ttccagtacg gaatcccctt tgtttacttt
      421 tatttcaatg attttgccgt cacggtcggc attgatgttg ttttccatct tcatggcttc
      481 gaggacaagt agattctggc ctctcttgac agtatcaccg actttacagt taacctgcag
      541 gattacacct ggcagcggag atttgacagc gcccttggtg gttgaggctg ccggacggga
      601 aataaccggt tcgccacttg ccgttgtagg agcttgagcc gggcgtttca gtgtaaccat
      661 ctgttttttt gccggtttct ccatttttac ctgataggga gtaccgttta cttctacttc
      721 agcgatgtca tccactaccg agctgatatg tactttatat acgttaccgt taatagtata
      781 tttaaaactt ttcattcttg tttgttttta gagataatta ctttttggga acttcacgca
      841 gaccgtaaat cttggaactc cacggagaat aagatctttg aaccttgcgg atcgtcagaa
      901 ccgtatgttc gatgtcgtgg ttgtcgtcgc tcatttcgta tagagccgca ccgatagccg
      961 caaagatttc cccggattcc tgacctgcat tgtctgcaat aacagccgct ccggccgctt
     1021 tctgtgcatt gcgtttgctg gccgcgatcg agagctttcc gatttgttta aagatgatga
     1081 acaacaggaa taatccggag aacacaactg ccatggcagt cagggtcata ccgatacccc
     1141 aagaatcatt ttctttaaag ttctcgattt tctcgttaga atccaatgtt acgttattgg
     1201 tgctgggtgt aacttttgtc agagcagtcc attcaccttg tccgtctaaa gttctaccat
     1261 agctgacatc tgctttttgt gaagcaggga taacgatctc atcgatcaga gttttaccgt
     1321 ctgcatcgta taacgcaatg taattttctt ttgatgggtc gagcgtgaaa ttgacatgga
     1381 atgttccccg atccggttct ccgtctgccc agaacaaagt gtgctggcga ggaggaatta
     1441 ctgttagaac gtcgcccttc ggaatcggat attttttcgg gttgctcttg tcattagtca
     1501 agtagcaacc ggcgatattg accgaaccgg ccgaattgtt gaacaattcg atccaggcat
     1561 ggcgtttgcc gtaatcatca acaaagttat cttcgttgat gaccagcact tcatttattc
     1621 gcatggaggt tgcacgctgt gcttttgccc cgaatgaaac gagcaacgcg aacagcagca
     1681 atacccctat tttcttatta atcatattca tttcctgttt taagaattat agaggcagat
     1741 tgtcatgttt cttggcagga ttgcttaact tcttggtctg caattgttgt aaagcacgaa
     1801 taatacggaa acgagtgtta cgaggttcga taacatcgtc gatatagcca tattgagctg
     1861 cattgtatgg gtttgcaaat gcttttttgt attcggcttc tttttctgca gcgcaagctt
     1921 tcggatcttc cgaggcagcc acttcttttg caaagatcac ttctacagcg ccgcttggac
     1981 ccataactgc gatttcggct gtcggccatg cgtagttcat atcgccacgc agatgtttgg
     2041 agctcatcac acaataggca ccaccgtaag atttacgcaa tgttacagtt actttaggca
     2101 ctgtggcttc gccgtaagcg taaagcaatt tggctccgtg caggataacg ccgttgtatt
     2161 cctggcctgt acccggtaag aatcccggta cgtcaaccaa tgtaaccaaa ggaatgttga
     2221 aagcatcaca gaaacggacg aaacggcctg ccttgcggga ggcgttgctg tccagacaac
     2281 ctgccattac tttcggctgg ttggctacga taccgacagt ctggccgtta aaacgggcga
     2341 aaccgacgat aatgttcttg gcatagtcgg catgtacttc cagaaattcg ccgttatcga
     2401 tgatggttcc gataacttca tacatatcgt aagcttggtt aggattgtca gggatgatgt
     2461 cgttcaggtt gtcatccaga cggtcgatcg ggtctttaca ttcgatcaga ggagtttctt
     2521 ccaagttgtt ctgcggcagg aagctgatca atttgcggat caactgtaaa ccgtcttctt
     2581 ccgtatcgac tgcgaagtgg gccacaccgg atttggtcgt atgtacgctt gcgccaccta
     2641 attgttcctg tgtaacgtct tcgcctgtaa ctgtttttac aactttcgga ccagtcagga
     2701 acatgtaact tgttccgcgg gtcatgatat tgaagtctgt cagggcagga gagtaaaccg
     2761 caccgccggc acatggaccg aagataccgg aaatctgagg aataaccccg gaagccaaga
     2821 tattacgttg gaagatttct gcataaccgg ccaaggcgtt gacaccttcc tggatacgtg
     2881 caccacccga gtcgttcaag ccgataacgg gagcacccat tttcatagcc tgatccatga
     2941 ctttacagat cttcatggcc agtgcttcgg ataaagcacc gccgaataca gtgaaatcct
     3001 gagcataaat atataccaga cgtccgtcga tcgttccgta acctgttacg ataccgtcgc
     3061 ccaaatactt agttttttca ataccgaagt ttgtacaacg atgttgtacg aacatatcga
     3121 attcttcaaa acttccctca tccagcaaca tggcaatacg ttcgcgtgcg gtgtatttac
     3181 cttttttgtg ctgagattcg attctttttt ctccaccacc taaacgagct gtttcgcgaa
     3241 gggcgataag ctcctttact ttttcaagtt ggttactcat tgtactatag atttgttgtt
     3301 agaaatgaac ttatttaatt ggcaattgac gattgagaat tgccaattga atagcatcaa
     3361 ataattgtca attctcaatt gtccattgtt tcttattttc ccggcatgca aagttcggtc
     3421 agaacgctgc atgtcgattt cgggtgaagg aatgctatgt tcaagccttc tgcacctcca
     3481 cgaggagctt tgtcgatcag cttgatacct tttgattcgg cttcgtccaa tgctgcctgt
     3541 acgtcgggaa cagcaaatgc aatgtggtgg ataccttcac ctttcttttc gataaattta
     3601 gcgattgtac tgtcttcact tgtcggctcc agcaactcga tcttagtctg gcctacttta
     3661 aagaatgcag tttttacttt ctggtctgct acttcttcga tgttgtagca ttttagtcct
     3721 aaaacttctt cataatacgg caggcaagct tcgatgctct ttactgcgat acccaaatgt
     3781 tcgatatgtg taagttccat gtcaataata atttagtaat ttaatattgc tttttgttct
     3841 atgttggcaa aggtacactc tttttattaa tagagaaata attcgttaat atttatcagc
     3901 atgatccaga tatgtttaaa aagcatattt ttgaaatcat gtggttaaaa atcaacgata
     3961 agtcgaatat tcaattgcct tccggtcagg taattaggaa ttgcgtactg gtggttgtct
     4021 atattggtaa tccaataata ggaactagtg ttctttatgt cgaacaagtt gaaaatatcc
     4081 aacccgagcc aaatgttctt gagattgcgg aagaatccgc gatccatgat tgcatccgtt
     4141 cccccggcaa gctggtagga gaaaccgagg tccacgcgtt tgtaggtcgg agtacggaaa
     4201 tagccgtcct cgtagcctgt acgtggggct gtgacgggaa ggccgccgga cagtacgcct
     4261 ttcagattca gtttgacacg tttgtatccg gggaaataat cctgaaaaaa gagcgagaca
     4321 ttataacctt ggctgttagg catcggtaca tattcgctcc ctcggatgct ttgctccgct
     4381 ttcattaggg agaagctgat ccaggagtcc gtacccggaa caaattcgcc gaagaatttg
     4441 acatcgagcc ccatcgcatg gccttgcgca cagttctcgc cgtagtatcg gattttgaca
     4501 ttatccaccg tataggggtt caggttatcc aattttttat aatacatatc ggcactgact
     4561 ttgaaatttc tgccggatgc ccggaatgta taatcgcctc ctgcaatgac atggatggaa
     4621 cgctgtgatt tcaggttttt gttcagttgt atgatactgt tgccgtgttc gtcctgcaca
     4681 gttgtacgta attccttata gaacggagac tgataataca gaccggaagc cagccgaaat
     4741 gtcaggttct ggtcgaagtt cggaatgaaa cctattgaag cacgcgggct gaatataaat
     4801 tccctgttat aactccaata gctgccgcgt acaccaccaa ccagcgtgaa cagtccttgt
     4861 ttggtacgaa acttgaatac atcctgcaaa taaccggaaa tacgtgtgct ttccagtttg
     4921 ttatccgaga acaggtttgc gatcacgttg acattcccgc ccccttgcgg taacgagtat
     4981 ccggcggagt cgcgtttttc ccattcgctg atcttgtcgt tgattttctc caactggacg
     5041 gtagcacccc atttcaacgt attgtttttt atgcgagcga caccataatg cccgacattc
     5101 atgatattgg agtgcagacg gttgcgagcg tgctcgttat agcgtgcgat ggataaattc
     5161 tgtatttctc cgcctccttc ttcggctgca tctcccagcc agtaatcacc ggcaatatca
     5221 tatccttcct cttccttact ggtaaaggcg gatgcttgca agccgagttc cgtattgtcg
     5281 ttcaggttat gctttaaagt gagtgctccg aataacgttt cgaacttatc ccgttcctgg
     5341 ccactcatga atactttaaa ttttttggca tttgttgccg ttccaaaaga agtctctcgg
     5401 gtgtggggaa tgaacttata attgtttatg gctaagtttc cgagaaagtt gatctcccat
     5461 ttgggggcaa gctggtatgt catataagtc tgcaaatcaa tgaaattagg atcatattcg
     5521 gcatccgtat cggttgtttt caaaagagat cgtcctgttt tgtaacggaa accggtcacc
     5581 tgtgtgaact tgccggaaga actgcccaca taagcattgg ctcccagcag gctggcggaa
     5641 gccgaacctt cgaatccttt cggttttttg taggtgatgt ccagcacgga actcatcttg
     5701 tccccataac gggcttcgaa tcctccagcg gagaaattga cggcttccgt catgtccggg
     5761 ttgataaaac tcaacccttc ctgttgtccg gaacggatga gcagcggacg gaacacttcc
     5821 agtccgttca catatacgat gttttcgtca tagctgccgc cgcgtacgga gtattgcgaa
     5881 cttaattcgt tattggaagt aacgccagca aatgtaacga ccagactttc aatgcttcct
     5941 ccggcagggt cggggagtag tttgacgcgg tcggcattca gggtttcaag agtggttgtc
     6001 tgctttcgga tggcggtagc tacgacttct cccagttcga gtgatgtata gttcatctgc
     6061 acgttgagac gcatatcttt ggttacttga ggtaggatcc tttcggcctt gttgtagccc
     6121 aggcatgaat agataagcgt caccgagtca ccggtagcaa ccgaaagcga gtagtggcct
     6181 ttttcattac tcatcgtccc gtttaacgtg ttcttgaccc ggatattgac caagtccagc
     6241 ggattaccat ccgcgtcgcg gatataaccg ctgattttgg cacgtccctg cccgaaagca
     6301 cttatcgaaa ataatataaa tagtagcgta gctattgcac gaatcttcat attccatcta
     6361 attattaaat ctacaaacgc gggaaacaac gatttatttt caacgaaagg caatttctca
     6421 ctatctttgt gccttgtata aataattaag gaaagaagat gcctttaaac ctacagaaga
     6481 acttgccagc tgttgagctg ttgaagaaag agtacatctt tgtgatggac tcgttgcgtg
     6541 cgtctgagca ggacattcgt ccgctacgtg tagttgtgct gaacttgatg ccactgaaga
     6601 tcacgacgga gacagacctt gttcgcctcc tgagcaatac ccccttgcaa gtggagctcg
     6661 actttatgaa gataaaaggt catactccca agaacacgcc gatcgagcat atgaaggaat
     6721 tctataaaga ctttgacgag atgcaggatg atttttacga cggcatgatt atcacaggtg
     6781 ctccggtaga gcagatgcct ttcgaggaag tgaactattg ggaggaagtg accgagatat
     6841 tcgattgggc gcgtacgcat gtgacttcta ccttatatat atgctgggcg gcgcaagccg
     6901 ggttgtacca tttttatggt gtccccaaat atgatctgcc agccaagatg ttcggcgtgt
     6961 tccgccatac gttgcgcgag ccctatgtgc cgatcttccg aggcttcgac gacgagttct
     7021 atgtgccgca cagccggcat acggagatac gccgcgagga tgtgatgaaa gttcccgatt
     7081 tgacgctctt gtccgaaagc gaagagtctg gtgtctatat ggcgatggcg cgcggaggac
     7141 gcgagttttt tatcaccggg cattccgaat actcgcctta cacgctgaat gacgagtata
     7201 tgcgcgacgt gaacaaggga ttgcctattg ccgttccccg taactattac cgtaataaca
     7261 atccagccct cggtccggtg gtccgctggc gtggtcatgc caatcttctg ttcaccaact
     7321 ggctgaacta ttatgtctat caggaaaccc cgttccgtat cgaggatatc agcaagttgg
     7381 gtgatttgta atcaagaaat aagaaataat agcatgcaaa caaaatcccg tcctatagaa
     7441 cttctctctc cggctaaaga cctcaattgc gggattgaag cgattaatca cggtgccgat
     7501 gccgtctata tcggtgcgcc caagttcggt gcgcgttctg ctgccggcaa ctctttggaa
     7561 gatatacgtg agctttgcgg gtatgcccac ctgtatggag cccgtatcta tgttacgctc
     7621 aacacgatcc tgaaagaaga tgagttggaa gaagccgaac ggatgatctg ggatctctgg
     7681 cgtgtcggga cggatgccct gatcattcag gatatgggga ttacccggct gaacctgcct
     7741 cctattccgc ttcacgccag cacgcagacg gacaaccgca caccggaaaa ggtccgtttc
     7801 ctcgaagccg caggctttac acaggtggtt ctggcacgtg aattgtcgct gaacgagatt
     7861 cgccggatat cggaagcgac taccgttccg ctggaagtat tcgtgcacgg cgccctctgt
     7921 gtcagctata gcgggcaatg ttatctgagc gccgctttga gtggacgtag tgctaaccgc
     7981 ggagaatgcg cccaatattg ccgcctgccc tatacgatgg ttgatgcgac agggacggag
     8041 atcgtcaccc ataaacactt gctttcgctc aaggacatga accgctccga ccagctggaa
     8101 gccctgttgg atgcaggtgt ttcttccctc aagatcgaag ggcggttgaa agatgtcggc
     8161 tatgtcaaga atatcacggc ttattatcgg aagaagttag atgcagtcct gtcccgccgt
     8221 ccggaatatc gtcgtgcttc tgctggacga agcacttata cgttcgagcc ggtagctgaa
     8281 aagagtttta accgtgggtt caccccgttc cttttggagg gacggacggc ggatattacc
     8341 gcttttaata cacctaagtc gttgggcgaa cctgtcggaa cagtcaagga gatcaaaggt
     8401 aattccttta ccgtggccgg cttgaagcag ttgaacaacg gagatgggct tgtttttttc
     8461 aataggaaag gcgagttgga gggctttcgc gtaaacaggg tggaggcaaa ccgggtgttt
     8521 ccgctggata tgccgcagct tgcccccaag actccgcttt accgcaattt cgaccaggcg
     8581 tttgataaac tgctagccaa gccttcagcc gaacgtaagc tgtccgtgga gatcgagttc
     8641 ttggacaatc ccttcggttt tacgctttgt atggaggatg agacgggagc acggatcatg
     8701 ctgaccgagc cgtttgcaaa agagctggcg cgtcgtgaac agcaggataa tatacggaca
     8761 cagctatcca agttggggaa tacgcctttc gaggcatcga aggtggtggt cggtttgtct
     8821 gaaaactggt tcgttccctc ttctctgctt gccgatatgc gccgtagagg agtggagaag
     8881 ttgctggaag cacgccgtgc ccgctatcct cgtgagacag tgaaacgtgt gcagccgtcc
     8941 gtgtcgatac ctttccccga acgccaactt acttatttgg ggaatgttgc caacgggaaa
     9001 gcccgttcgt tctaccagga tcacggggtg gaacagatcg acccggcatt tgaactgtct
     9061 ccccggaaag atgttccgtt gatgtttacc aaacactgcc tgcgctacag catggggtgg
     9121 tgtcctactt atcagaaaga caagtctccc tacaaggaac cgtattatct gctttataaa
     9181 gatacgcgcc tccggttgca gttcgactgc aagcattgtc agatgttggt atttgaaagt
     9241 tgaaaattat gagaacgcta ttgtcaggac ggataagaat gactgtccgg tgaaagaagc
     9301 catgatccgt ttgacaaaag tattccagca ataaaggagc cgataggtat gtgataacag
     9361 tttcataggg atggaatgat agtttcatgg ggatgaaaaa gaagtttcat ccctatgaaa
     9421 ataaagtttt ctttaagggg aacgggaagg tagtgcaagg ttatatagcc tttcctaata
     9481 actccatata ttttgccacc cctttcgtgt cttctggagc cggactccag ggtgcgaaat
     9541 tttccggagc gagcggagcg aacggccctt ccttgatttc atatatgaca gagccggatt
     9601 ctagaactaa cagcccgtgc catgttcccg cctttatttc ggcgccgtag acaccttctt
     9661 tcggatcgag tatttgtgtt ttggtgattt cccctttgtt gtcaaagagg aatacagcaa
     9721 tgcgacctcg cagcaggagg aatatttcat cttttttagg gttcagatgg cggtgtgggc
     9781 ggaggtaggt tcccggttca agggcattga gcaagcggtt gacgggatcg tccaaatgct
     9841 catgaaagtt gtagttcatg cgtagtcggg gcgactgttt ggcacgcccg gtcgtttcat
     9901 ccaataaagc ttcgtttatg atcttcatgc gaataattga ttactggagg acgaatgtac
     9961 aaaataaata ttggctggta tgccatttct ccgtacattt gcagaaacct gtaaataaaa
    10021 cagaatgaaa cctgctctaa cttattacgc tctactggcc ttatttctgg cattctgttt
    10081 ttcctgtaaa acagattcgg agaagaaaaa gtatgttatt ggcgtctcgc agtgtacgct
    10141 tgaaggttct tggcgtaaat cgatgttgct ggatatgaag gtgcaggcct ccgaatatcc
    10201 gggcgtctcc ctgttagtcg aggatgcggc ggacagtagt ctgttgcagg tggagcagat
    10261 acgcagcctg ataaaacgta aggtcgatct attgattatc tccgccaatg aatcggaacc
    10321 tgtcactcct attgcgattg aggcctaccg tgccggcatt ccgactatcc tggtagaccg
    10381 gaagatcagt tcggacgaat atacgactta tatcggtggt aacaattacg agatcggtcg
    10441 ccaggccggc tttttcgtga accgacaggt gaaagagaaa tatcctaccg tattggaagt
    10501 atggggcttg tccggttctt ctccggcgca ggatcgccat cgcggtttta tggaggtttt
    10561 gaactcccgc atcaaggtga aggaaatatt cgggaaatgg aagccggaaa cggtggagaa
    10621 ggagatagcg gaaatggatt cgctggagga ggtggatgtt gtgtttgccc ataatgatgt
    10681 gatggcaatg gctgcccgca gggcaatcga aaggatgcat cccggattgg cggacaggat
    10741 ttgttttgtg gggatcgatg ccgtttcggg acggggatcg gggctggaag ccgtcatgca
    10801 cggagagttg gccgcttcgg tcttgtatcc gacgggtggg agccttgcta tccgtgtagc
    10861 catgcagata ttgaacggag aagatgtgtc tcggcaatat ttgctctctt ctgccttgat
    10921 cgataagaac aatgccggaa cgctgtttat ccagtccgaa caggtggtcg actatcagca
    10981 ccagatcgag ttgcaacggg agaatttgga gagtatgctt tccaaataca cgttcctcca
    11041 aaactccgtc ggcattatcc ttttgctgat ggggatgttg cttttgtccg ccttgtacgt
    11101 gatccatgtg aaccgggcgg tgaagcggaa gaaccgcgag ctgaaacgta cgaacttgca
    11161 ggtacaacag caaaaagaag aattggctga ggcaaaccgt tatattgaga agtcgacggc
    11221 tcagaaactg caattcttta ccaatatcac acacgagatc aagacgccgt tgacgttgat
    11281 cctcggtccg ctcggcaagc tgtcgaaaga ggctccggaa ggttcttcat tggcagacga
    11341 tatccgtatc attcggaaaa atgcggaaag gttgaagaga gtcgtggacc agttacttga
    11401 ttttcgaaag gtagagagca ataagatgaa tatgcgggtc ggagaggtag atttagttgc
    11461 ttttgtggca gaagtgaaat cttatttcga tacgatggct accaccaagc agatacattt
    11521 cacgtttgag catgactgcc cttctgttaa tatatgggta gacagggata agatggagaa
    11581 gattctggcc aatcttttgt ccaatgcatt caagttcacg ctggacggag gtacggtcac
    11641 gatccgcctg aaggataaag gagatcaggt cgagctttct gtcgaagata atggcaaagg
    11701 cattccgtcg gaaaatattg cttccgtctt tgaccgtttc tttaccggtg accagaacta
    11761 tgtgacgggg acggggatcg gtctgcactt gacgcgtgag ttcgtccaca tgcacaaagg
    11821 cacgatccgg gtggagagtg ttccgcataa gagtactgtc tttacggtca tcctcttgaa
    11881 aggtaaatct cattttgacg aatcttgtat attcgatctt tccgtaaccg agctttccag
    11941 tggtgtcgcc gacttgaaca cggatgaatt gcaggaggtt ttgaaccgta cctacaatta
    12001 tactgttctg gtcgtagaag atgatcttga tatacagagt tacttgcagg cggaattaaa
    12061 acagaacttc cgtgtgttgg ttgccgataa cggcgtgaag gctttggagg tactgatgaa
    12121 cgaagagatc tcgatggtta tcagcgatgt tatgatgccg gaaatgaacg gtttcgatct
    12181 ttgtcgtaag atcaagtcgg atattgtcct gagccatctt ccggttatgc tgttgactgc
    12241 tttgtccgac gacaaacagc agatgtacgg ggctgccagt ggtgcggacg cgtatatcca
    12301 gaaacctttt aacatagaag tcgtgaaact gcgtatcatc aagctgctgg aggaccgtgt
    12361 ccggttgcgt gaggcttatg ctcgcgatgc ctcttcgcct gctgtttccg tgaaggagga
    12421 aaaagcggga agcatggacg atctttttat gaatcgtttc ttgaaactga tcgaagagtc
    12481 ctatgccgat ccggatttca gtattgagaa aggcagtgaa aaattgggct tgtcgcgtgt
    12541 gcatctttac cggaaggtga aggagcttgc cggagtgaca ccgactgatt tcctgcgtaa
    12601 ctatcgtttg aagaaagctg ctgctctact ccgacggaaa gccgggaatg tgaatgaggt
    12661 ggcttatgcg acgggcttcg gttcgcctgc ttatttctcg aaatgtttta aagccgttta
    12721 caatattact ccgacggagt atctggaaaa ggaataatat tcttctcttt aataacgctc
    12781 gttacatttg tgtaacattt gtgcatgtaa ctcgaaaata agagtataat gtaacaagtg
    12841 ttatcaatct tgtagcatta gttatcgtcg catctgctac ctgtctctat ctttgcatcg
    12901 tagataataa attatccttg tcaaataaac tataatgaaa caatgcaaag caacaataag
    12961 aaaccggtcg tagtaggcat aggagaactc ctgtgggaca tgttgccaac aggaaagaaa
    13021 gcaggtggtg ctcctatcaa ttttgtctac catgcgtcgc ggttgggggc ggaaggatat
    13081 gctatcagcg ccgtgggaga cgatgggctg gggcgcgaaa tcctcgaaga actggataat
    13141 aattcgatcc ggtatctgat cgagaaagtc ccttatccga ccggaacggt acaggttact
    13201 ctgcaggatg gtgtccctga ctatattatt aatgaacgtg tagcttggga tcatctttct
    13261 ccgacgtcaa atgcgattga tttggccgaa cgggcggatg ccatttgctt cggtacgtta
    13321 ggacagcgtt ccgcacagtc gagagagacg atacaagcga ttctttcttt tgccccggac
    13381 gatgcttatc gttgttttga catcaatttg cgtcagcatt attatacgaa agagttgatc
    13441 gaagagtcgc tttatctagc aaatatgttg aaggtgaatg acggggagtt ggtcgtcctg
    13501 cgggatatgt ttcatttgga aggaacggac aaggaggtgg ctcattggtt tatagaacac
    13561 tataatctcc gcttggtggt tctgacggcc ggaggagctt atagtacgat atataccgct
    13621 aatgaagaat cgattttgca aaccccggaa gtgcaggtgg cggatacggt tggagcaggt
    13681 gatgcttttt ccggagcatt ggtcatttcg ttgctgaaag gggcttcgct aagggaagcg
    13741 catgaatttg ccgtccgcac agctgcttat gtctgtacga aagagggggc atggccggca
//
