LOCUS       c00135_gnlPro..        14896 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FCHBOAHN_135.
ACCESSION   c00135_gnlPro..
VERSION     c00135_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 08:04:02
            Original ID  :: gnl|Prokka|FCHBOAHN_135
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14896
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14896
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2586:9722]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2587..9722
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14896
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14896
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(474..821)
                     /locus_tag="ctg135_1"
                     /transl_table=11
                     /translation="MNIINKIEQEQLKADVTPFNVGDTIKVHTRVIEGGKERIQIFQGI
                     VIAKRGSGINEAFTVRKISYGEGVERVFPLHTPRIAKIEVVNRGKVRRAKLHYLRGRIG
                     KDAMIVKSANR"
     CDS             complement(931..2469)
                     /locus_tag="ctg135_2"
                     /transl_table=11
                     /translation="MFKSGLAVLFLLASWFSASCAYELLPAHVAVVYNGKSELSRRMAR
                     EYARVRGVPEGNLVSLDCPTTSEISRKEYEDTIRVPLLEAARKQRWWVPSGIASSPLMN
                     RKIFVLVLMADLPMKIRHETPAPLPGKGVNQMQTDRAAVDSELALLAVGGYERKSWQVN
                     PYFNKREDFVGSGLPSFLVCRLDGLTPDTCMRLVAEPANVEKKGLWGWAVVDRGGPYAQ
                     GDRWLDDVFERVREAGIPAYLDDWPQTLPEKFPLSRDTALYCGWYAGNANGPFSDPSFR
                     FRPGAIAMHLHSFSAADFKVPGRGWSSALLEKGAAVTVGNVYEPFLGACHRFDIFVDRL
                     LDGYTVAEASWMSMPVLSWQGLVFGDPLYRPYARMKDMDVEPTEEDRYFQGWWASSVQF
                     GDRWKDRSARLMESARKAPFSCLYEALALECLYRKEPARAGELLSSALDGAADARTRAR
                     LLLEILMAERARGGNKAFLQRADGIRGLMSSSAFLPALEEWLARVAPPPDPPEK"
     CDS             2587..3057
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg135_3"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1e-25, bitscore:
                     80.1, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYCRPPPCIPYNHHTHMIQQIDHIGIAVKSLDATVPYYRDALGLG
                     EPHIEEVPTQKVRVAMFDVAGVHIELLEPTSPESAIAKAIEKKGEGIHHIAFKTNDIAG
                     NISQAKEAGLTVLNDPPVPGAHNTQVTFLHPKCTFGVLTEFCQHPGGCECGK"
     CDS             3089..4654
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg135_4"
                     /sec_met_domain="CT_Vparvula (E-value: 1.3e-216, bitscore:
                     709.8, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIDPKLIDDLNSRRKKVILSGGQEKIDKRHEKGEMTARDRMGYL
                     FEEGTFSEIGMHVRHNCHNFGMGKKEIPGDGVVSGFGLVDGRPVACAASDFLAQGGSLG
                     YMHAMKIADAQKYALKAGIPMVTVNDSGGARLQEGVAALSGYAQVFYNNVLASGVVPQI
                     SMILGPCAGGAAYSPALTDFIIMRNSGNAGMYITGPKVIEQVTYEKCTMDDIGSAAIHA
                     TVSGNVHFVADSDAHAMDILKRLLSFLPSNNTEEPPHKLDTPLDLSADEGMSDLIPGDN
                     RTPLDVQPIISRLVDNGDFLEVHKDFAKNVVVGFGRICGVVVGIIANQPNVKAGCLDID
                     SSDKAARFIRFCNAFNIPLVNLVDVPGFLPGKNQERGGIIRHGAKLIFAYSQATVPKVT
                     LIMRKAYGGAYIAMCCKDLGADAVFAWPGAEIAVMGAEGAVPVLYGRELKAVEDPAEKA
                     KRQGELLEEYREAFYNPYVAAGMGQITEVINPEETRAKIAFALRTLLNKKEVRPAKKHG
                     NIPL"
     CDS             4676..5122
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg135_5"
                     /sec_met_domain="OAD_gamma (E-value: 3e-11, bitscore: 33.8,
                     seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLTTLAFAQGIANVMNNLNYQIVGIMVVMMCLGGLAVILTISGS
                     IAAAIQNRAKAKTAAPVAAPAAAPAAAGKPGMTPEMLAILSAAVDSAMTELTPEMVAVI
                     SAAVDAGLDGMSHRIVEIKQSPGSGYAAAGRAEIFASHRIRPSR"
     CDS             5197..5604
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 58.7; E-value:
                     1.3e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg135_6"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.9e-19, bitscore:
                     58.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLRITVDGKVFDVSVELLDQVSSTTAAPAPAPVAAPAPAASAP
                     VATPAPAPAPAPAPAPAAAGAGDVPSPLAGKVVSLDVAAGAPVKAGDQILTLEAMKMNT
                     IIYAPASGTLTAFCVNPGDTVQEGQALAKIG"
     CDS             5722..7347
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg135_7"
                     /sec_met_domain="OAD_beta (E-value: 9.3e-160, bitscore:
                     521.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVFSLSWQMVGMWGIAILLLYLGVAKQYEPLLMVPIAFGALIAN
                     IPDNGMLITQLNQQVISSNEQGEVTSTSLNNVGYLRVHVAPLQQTPAKVPANLTTPEAR
                     AQYLETMQQPMQVYPGSQLTVSKIKSVRESQEKAKADAARLGDDSLTVDPNLKDFQNVT
                     EDNGNEPVFLLTNGEGTTVVRQQGVNYFDTSGNRVPVDLKTQKLEPLVVSAAGKYVAVG
                     QHTQELLVTSIHGGLYDWIGLGIKAEIFPPIIFLGVGALTDFGPLLAAPRTLLLGAAAQ
                     VGVAATFFMALFMGFNPNEAASIGIIGGADGPTSIFLTMKLAPHLLGAVAVAAYTYMSL
                     VPLIQPPIMALLTTKKERLIRMKSLRTVSKSEKLFFAVLVTIVTILLIPDASPLIGMLM
                     LGNFLRECKVTERLVQASQNEIINIVTIFLGTSVGLTMQGDRFLQAETLLIILLGIVAF
                     GVATAGGVIAAKLMNLIWRKNPVNPLIGSAGVSAVPMAARVSHNVGQKYDPSNYLLMHA
                     MGPNVAGVIGTAVIAGYYIATLAK"
     CDS             7385..8164
                     /locus_tag="ctg135_8"
                     /transl_table=11
                     /translation="MNSAASFSTPPEEEGPCGDWTYHEWAEAFSTNDLARSLPPGHIAV
                     CRVQTGGRGRFNRKWIGEEGGLWASFTVPLSAPADTAAGVHWGHLPLVAGLALFNMLRG
                     MGLDSVRLRWPNDLLAGKSKLAGILVERPAENMAVIGIGINVFNDVASIAGEIKDPPAR
                     LADLVRDCPSLHAVMASLGSHLNQVLSVFSHGGVSALQEGLSRAWAGERPVSILTDDET
                     VRGIFTGIDDQGNPVLSLPAGAVRTIPAHLINRLLEE"
     CDS             8226..9722
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: AcetylCoA_hydro"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: AcetylCoA_hyd_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg135_9"
                     /sec_met_domain="AcetylCoA_hyd_C (E-value: 7.9e-47,
                     bitscore: 148.9, seeds: 181, tool: rule-based-clusters)"
                     /sec_met_domain="AcetylCoA_hydro (E-value: 5.6e-44,
                     bitscore: 140.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYKVLTPEEAASLIKHGHHIGLSGFTPAGTAKAVTAALAKIAEA
                     EHEKGNPFQVSVFTGASTGDSCDGILSRAKAIRYRAPYTTNVDFRKAVNNGEIAYNDIH
                     LSQMAQEVRYGFMGNVDIAIIEACEVTADGKIYLTAAGGIAPTICRLADKIIVELNAAH
                     SKSAMGLHDVYEPLDPPYRREISIFKPSDRIGKPYIQVDPKKIVGVVETNWPDEARSFA
                     AADPLTDKIGQNVADFLAADMKRGIIPSTFLPLQSGVGNIANAVLGALGRDKTIPAFEM
                     YTEVIQNSVIGLIREGRVKFGSACSLTVTNDCLEGIYRDMDFFRDKLVLRPSEISNSPE
                     VIRRLGVISINTAIEADIYGNVNSTHIGGTKMMNGIGGSGDFTRNAYISIFTCPSVAKD
                     GKISAIVPMVSHHDHTEHDVNIIITEQGVADLRGKSPKERAQTIIENCVHPDYKNILWD
                     YLKLSDGKAQTPQSIRAALGMHAELARSGDMKNVDWAQYK"
     CDS             9841..10542
                     /locus_tag="ctg135_10"
                     /transl_table=11
                     /translation="MNWMIYPAARAFIKVCAVLFGAGATAAALIHLFMPFFLRSPRTAA
                     PFLLLGTGAELLSILSLSFLMFWGARVLLASRGSKITRNLSMLAFLPALYALLIPFAGM
                     PASSQYTEMDRVWEAFLLLASVISFFSFPYTAGYGAAGRRLFLAWGISAAGCGLQSALF
                     FLAVLLRQFLTTAVPSLAAPVAWLAVLLSCGLEIMLAALSVILARRLFKEVMSIASMPE
                     SIDPSMPGNLP"
     CDS             complement(10820..11683)
                     /locus_tag="ctg135_11"
                     /transl_table=11
                     /translation="MKGIVLAGGSGTRLHPVTLSVSKQLLPVYDKPMVYYPISVLMLAG
                     IREILVISTPRDLPLYRDLLGDGSRFGVSFEYREQPRPEGLAQAFIIGEEFIGKDSVAL
                     VLGDNIFYGRGLTEKLRRAAELTSGATIFGYQVHDPQRFGVVEFNEEGKAVSIEEKPLR
                     PKSDIAVTGLYFYDNRVVEIAKRIPKSSRGELEITSVNQEYLKQGLLRVEKLARGYTWL
                     DTGTHDTLLEASMFVRTLEHHQGFKVACLEEIAFNNGWISQETLRSQAGAMNNNGYGRY
                     LDELVK"
     CDS             complement(11693..12745)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GDP_Man_Dehyd"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg135_12"
                     /sec_met_domain="GDP_Man_Dehyd (E-value: 1e-97, bitscore:
                     317.3, seeds: 258, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVIVTGGAGFIGSNLVRLLLERGHEVLNIDALTYAGNIHSLDGS
                     ADSPAYLFLHADVRDASLMRRTLREYAPDWVMHLAAESHVDRSIDDPGNFMTTNVMGTF
                     SMLQSALEYYRSLEGEKKERFRFHHISTDEVYGSLGKEGLFTESTPYRPHSPYSASKAS
                     SDHLVRAWHDTYGLPVLITNCSNNYGPYQFPEKLIPVVILKALGGAPIPVYGKGENVRD
                     WLYVGDHCEALLTVVSCGKPGETYNIGGNNEKTNLELVELLCSHLDELRPRPDGRSYRE
                     QISFVQDRPGHDLRYAIDASKIRRELGWTPRQDHSSGFRKTIQWYLDHEEWWRGILSGE
                     YRLERLGTNG"
     CDS             complement(12877..13821)
                     /locus_tag="ctg135_13"
                     /transl_table=11
                     /translation="MTSGGDAAGMNPAIKAAVDHARQLGMNPYVVYDGLEGLIDGKIKE
                     ATRELTNDMIYRGGTLLRSSRSKRFFDYEFRKQAYEHLKKRNIDKLIIMGGDGSFRALN
                     DFFNDFEVPFAGIPATIDNDIAGTDYCLGVDTAQNVILDCIDSVRDTARSHHRAFVIET
                     MGRDCGYLAMTTALCSAADICIVPEIPYDLESIYKRLQPVINEEGSCIIAVVAEGTRVA
                     QYLTRWLTERAGMDTRLTVLGHVQRGGSPTARDRLMGTRFATRAVEALNNGDINQIMVY
                     HDGQYGYASLDSVAGQQYSVNQDIINLCRELSC"
     CDS             13950..14681
                     /locus_tag="ctg135_14"
                     /transl_table=11
                     /translation="MNDTAAAILKATAALRDGTEKLRFESPVHVTYNPLTYAWGPHEQY
                     VRTYGNGEKGHLFLGMNPGPFGMAQTGVPFGEVDAVVNWLHIRGEVGRPEHTHPKRPVE
                     GFGCPRSEVSGRRLWGLFAEAFGTAENFFRHNYVANYCPLIWMGATGANITPDKLPAEQ
                     RAAVDAVCMEHLLSLITILNPHTLVGVGAYATQKLRDAASRLPGKSFTIGTLLHPSPAS
                     PIANKLWPERPIQQLKELGIL"
ORIGIN
        1 gaccggaaga tgcggaggac acaccggctc ccgcacctgc ggaaaaataa ttatccacgc
       61 agccctgctc ccgcttaccc ccctccgggg gccatgctga aaaccgccgt ttcctttccc
      121 cttcccggaa agcaggttgg ggcagggcct gatggaatgt cacacgctaa gttcctggtt
      181 tggcttcgcg tatgaaattt tccggtttct gctccattct ccggaagcca tccaggcccg
      241 gacggaggaa aatccgaaaa acgtatttgc gccggaccgg aaatagccgc ccctctccac
      301 cttccccacc ccggaaaaac gctctcatcc ccatatggct cccggggaaa tatcctgaag
      361 cggctgtcgt ccctgtggac ccctttccca ttcaggaaaa acaatactcc ggaaataaaa
      421 aacccggcgc cgcctcacgg cgggccgggc cagcaaaata gcaattcttc cgattaccgg
      481 ttggcagact tcacaatcat ggcatccttg ccgatgcggc cgcgcagata gtgaagtttg
      541 gcgcggcgga ctttgccgcg gttcacgact tcaatcttgg caatgcgggg agtatgcagg
      601 gggaatacgc gttccacgcc ttcaccgtag gaaattttgc ggacggtgaa agcttcattg
      661 atgccggaac cgcgcttggc gatcacaatg ccctggaaaa tctggatacg ttccttgccg
      721 ccttcaataa cacgagtgtg aaccttgatg gtatcaccta cgttaaatgg ggtcacatcc
      781 gccttgagtt gctcttgctc gattttgttg ataatgttca tcttgtgtta tctattgctg
      841 gtgaatatca gtaaaaggaa aacttacggg acgcagaata tgagccataa tcccctaaaa
      901 ggcaatccaa atttgccgta cgtccttaat ttatttttcc ggcgggtccg gcggcggagc
      961 caccctggca agccattcct ccagcgccgg aagaaaagcg gaggaagaca tgaggccccg
     1021 gatgccgtcc gcccgctgca gaaaagcctt gttgccgccc cgggcccgtt ccgccatcag
     1081 gatttccagc agcaggcgcg cacgggtgcg ggcgtcagcc gcgccgtcca gggcggagga
     1141 aaggagctct ccggcgcggg ccggttcctt ccggtacagg cattccagcg ccagagcttc
     1201 ataaaggcag gaaaaagggg ccttccgggc ggactccatc aaacgcgcgg aacggtcctt
     1261 ccagcggtct ccgaactgca cggaggaagc ccaccacccc tggaaataac ggtcttcttc
     1321 cgtcggctcc acgtccatat ccttcatgcg ggcgtatgga cggtacaggg ggtctccgaa
     1381 caccaacccc tgccaggaca gcacaggcat gctcatccag gaagcctccg ccacggtata
     1441 gccgtccagg aggcggtcca caaaaatatc aaagcggtgg caggcgccca ggaacggctc
     1501 atacacgttt cccaccgtca cagcagcccc cttctccagc agggcggaac tccatcccct
     1561 gccggggacc ttgaaatcgg cggcgctgaa ggaatgcaga tgcatggcta tcgccccggg
     1621 ccggaagcgg aacgaaggat ccgaaaacgg tccgttcgca ttccccgcat accacccgca
     1681 gtaaagagcc gtatcccggc tcaaggggaa tttttccggc agggtctggg gccagtcatc
     1741 cagataagcg ggaatgcccg cctcccttac gcgctcgaac acgtcgtcca gccaccggtc
     1801 cccctgggca taggggccgc cccggtccac aacggcccac ccccataaac cttttttctc
     1861 cacgttcgcc ggttccgcca ccagccgcat gcaggtatcg ggcgtcagtc cgtccaggcg
     1921 gcataccaga aacgaaggaa ggccggaacc cacaaaatcc tcccttttat taaaataggg
     1981 attcacctgc caggacttcc tttcataacc gcccaccgcc agcagagcca attcggaatc
     2041 caccgcagcg cgatccgtct gcatctggtt gacgcctttc ccgggaaggg gagcgggcgt
     2101 ttcatgccgt atcttcatcg gcaggtccgc catcagcacc agcacaaaaa tcttccggtt
     2161 catcaagggg gaggacgcaa tgccggaagg cacccaccac cgttgtttcc gcgccgcctc
     2221 cagcagcggg acgcggatcg tatcctcata ctccttccgc gaaatctcgc tggtcgtggg
     2281 gcaatccagg gaaacgagat tcccttccgg aacgccgcgc acccgcgcat actccctggc
     2341 catgcggcgg ctcagctcgg attttccgtt ataaaccacg gccacatgag cgggcagcag
     2401 ctcataggca cacgaggcgg aaaaccacga cgccagcaga aataacacgg ctaatccact
     2461 cttgaacatg cccctaccat acctcatctt ccggggcaat caagcaggtg aaaggggcgg
     2521 ccacgaattc gccatttttc cgcttttcgc ttcacatcct aaaaaaatac gctttaataa
     2581 ctcttgatgt attgcaggcc tcccccctgc attccctata accatcacac gcatatgatt
     2641 cagcaaattg accatatcgg catcgccgtc aagagccttg acgccaccgt cccctattac
     2701 cgcgatgcgc tcgggctcgg agagccccac attgaggaag ttcccactca aaaggtccgc
     2761 gtcgccatgt ttgacgttgc cggagtccac atcgaactgc tcgaacccac ctctccggaa
     2821 agcgctatcg ccaaggctat tgagaaaaaa ggggaaggca tccaccacat cgctttcaag
     2881 accaatgaca tcgccggaaa tatctcccag gccaaggaag caggccttac cgtgctgaac
     2941 gacccgcccg tccccggcgc tcacaacacg caggtcacct tcctgcatcc caagtgcacc
     3001 ttcggcgtcc tgaccgaatt ctgccagcac cccggcggct gcgaatgcgg caagtaacat
     3061 tctccctatt caccatacca ctataccaat ggctattgat cccaaattga ttgacgatct
     3121 gaacagccgc cgcaagaagg taatcctcag cggcggtcag gaaaagatcg acaagagaca
     3181 tgaaaagggc gaaatgacag cccgcgaccg catggggtac ctctttgagg aaggcacctt
     3241 ctcggaaatc ggcatgcatg tgcgccacaa ctgccacaac ttcggcatgg gcaagaagga
     3301 aatccccggc gacggcgtcg tttccggctt cggcctggtg gacggccgtc cggtggcctg
     3361 cgcggcctcc gacttcctgg cccagggcgg gtccctcggc tacatgcacg ccatgaaaat
     3421 tgcggatgcc cagaagtacg ccctgaaagc cggcatcccg atggtgaccg tgaacgactc
     3481 cggcggcgcg cgcctccagg aaggcgtggc ggccctttcc ggctatgccc aggtgttcta
     3541 caacaatgtg cttgcctccg gcgtggttcc gcaaatctcc atgattctgg gtccctgcgc
     3601 gggcggcgcg gcctactccc ccgccctgac ggacttcatc atcatgcgca attccggcaa
     3661 cgccggcatg tacatcaccg gccccaaggt gattgaacag gtcacgtatg aaaaatgcac
     3721 gatggatgac atcggctccg ccgccattca cgccaccgta tccggcaacg tccatttcgt
     3781 agcggacagc gacgcgcacg ccatggacat cctgaagagg ctgctttcct tccttccttc
     3841 caacaacacg gaagaaccgc ctcacaaact ggacaccccg cttgacctga gcgcagacga
     3901 aggtatgagc gacctgattc ccggcgacaa ccgcacgccg ctggacgtcc agcccatcat
     3961 cagccgcctg gtggacaacg gggacttcct ggaagtgcat aaggacttcg ccaaaaacgt
     4021 cgtcgtcggc ttcggccgca tctgcggcgt agtagtcggc atcatcgcca accagcccaa
     4081 cgtgaaagcc ggctgcctgg atatcgactc ctccgacaag gccgcgcgct tcatccgctt
     4141 ctgcaacgcg ttcaatattc cgttggtgaa cctggtggac gtgcccggct tcctacccgg
     4201 caagaaccag gaacggggcg gcattatccg ccacggcgcc aaactcatct tcgcctattc
     4261 ccaggccacg gtgcccaaag tcaccctgat catgcggaaa gcctacggcg gcgcctacat
     4321 cgccatgtgc tgcaaggacc tgggcgctga cgccgtcttc gcctggcccg gcgcggaaat
     4381 cgccgtcatg ggcgcggaag gcgccgttcc ggtgctctac ggccgtgaat tgaaggctgt
     4441 ggaagacccg gcggaaaaag ccaagcgaca gggagaactc cttgaagaat accgggaagc
     4501 cttctacaac ccgtatgtgg cggccggcat gggacagatc acggaagtca tcaatccgga
     4561 agaaacccgc gccaaaatcg ccttcgccct gcgcaccctg ctgaacaaga aggaagtgcg
     4621 cccggccaag aaacacggca acattccgct ctaacatcca tctcaacgga ttcatatgtt
     4681 actcacaaca ctcgcctttg cacagggcat cgccaacgtc atgaacaatc tgaactatca
     4741 gattgtcggc attatggtgg tcatgatgtg cctgggtggc ctggccgtca ttctgaccat
     4801 cagcggctcc atcgccgccg ccattcagaa cagggccaaa gccaaaaccg ccgctcccgt
     4861 ggccgcgcct gccgccgccc ccgctgcggc gggcaaaccg ggcatgactc cggaaatgct
     4921 cgccatcctc tccgcagcgg tggactccgc catgacggag ctcacgccgg aaatggtggc
     4981 cgtcatctcc gccgccgtgg acgcgggcct ggacggcatg agccaccgca ttgtggaaat
     5041 caagcaatcc ccgggctccg gctatgcggc cgcaggcagg gcggaaatct tcgcctccca
     5101 ccgcattcgg ccttcccgtt gaactacagc attattcacc cttacccccg ccccggcggg
     5161 aaccatttaa cttaatactc cataccatac attatcatga agaaacttcg catcaccgta
     5221 gacggcaagg tatttgacgt atccgtagaa ctcctggacc aggtatcctc cactaccgca
     5281 gccccggccc ccgcacctgt ggccgctccc gctcctgccg catccgcacc cgtggccacc
     5341 ccggctccgg ctccggctcc cgcacctgcg cccgctccgg ccgccgccgg cgcaggagac
     5401 gttcccagcc cgcttgccgg gaaggtcgtc tccctggacg tggcagcagg cgcacccgtg
     5461 aaggccggtg accagattct gacgctggaa gccatgaaga tgaacaccat catctacgct
     5521 cccgcctccg gcacgctcac cgctttctgc gtgaacccgg gcgacacggt tcaggaagga
     5581 caggcactgg ccaaaattgg ttaatcccgg cggcggcagc ccggaaacgc caacagtccc
     5641 gggctccggc tcaaataata aaccgctaca ataacattcc gtatgagtct ttttgattca
     5701 ttaatcacct ttttacaggg gatgggcgtc ttctccctat catggcagat ggtagggatg
     5761 tggggcattg ccattctcct cctgtatctg ggtgtagcca agcaatacga accgctcctg
     5821 atggttccca ttgctttcgg cgccctcatc gccaacattc cggacaacgg aatgctcatc
     5881 acccagctga accagcaggt catctcctcc aatgaacagg gggaagtaac ctccacgtcc
     5941 ctgaacaacg tgggctacct gcgcgttcat gtggctcctc tgcagcagac gcccgccaag
     6001 gtgccggcca atctgaccac gccggaagcc cgcgcccagt atctggaaac catgcagcag
     6061 cccatgcagg tttatcccgg cagccagctg accgtttcca aaatcaagtc cgtgcgggaa
     6121 tcccaggaaa aagccaaagc tgacgccgcc cgcctgggag acgacagtct gacggtggat
     6181 cccaacctga aggacttcca gaacgtgacg gaggacaacg gcaatgagcc ggtcttccta
     6241 ctcacgaacg gagaaggaac caccgtcgtc cgccagcagg gcgtcaatta ctttgacacc
     6301 agcggcaacc gtgttcccgt ggacctgaaa acgcagaagc tggaacccct ggtggtttcc
     6361 gccgcaggca aatacgtggc cgtaggccaa catacccagg aactgctggt cacctccatc
     6421 cacgggggcc tgtatgactg gatcgggctg ggcatcaagg ctgaaatttt cccgcccatc
     6481 atcttcctgg gcgtaggagc cctgacggac ttcggcccgc tgctcgccgc accgcgcacc
     6541 ctgcttctgg gcgcggcggc ccaggtgggc gtagccgcca cgttcttcat ggccctgttc
     6601 atgggcttca acccgaatga agccgcctcc atcggcatca tcggcggagc tgacggcccc
     6661 acttccatct tcctgacgat gaagctggct ccgcacctgc tgggcgccgt ggccgtggcc
     6721 gcatacacgt acatgtccct ggttccgctg atacagccgc ccatcatggc gttgctgacg
     6781 accaagaagg agcgcctcat ccgcatgaaa tccctgcgga cggtcagcaa gagcgaaaaa
     6841 ctgttcttcg ccgtgctggt aaccattgtc accattctgc tgattccgga cgcatccccg
     6901 ctcatcggca tgctgatgct cggcaacttc ctgcgcgaat gcaaggtgac ggaacgcctg
     6961 gttcaggcct cccagaatga aatcatcaac atcgtcacca tcttcctggg aacctccgtg
     7021 ggtctcacga tgcagggaga ccgcttcctg caggcggaaa cgctgctaat cattctgctg
     7081 ggcattgtcg ccttcggcgt agccactgcg ggcggcgtca tcgccgccaa gctcatgaac
     7141 ctcatctggc gcaagaatcc ggtcaacccc ctcatcgggt ccgcaggcgt ctccgccgtc
     7201 ccgatggcgg cccgcgtctc ccacaatgtg ggccagaagt acgacccctc caactatctg
     7261 ctcatgcacg ccatgggccc gaacgttgca ggcgtgatcg gcaccgcagt catcgcgggc
     7321 tactacatcg ccactctggc gaaataacca gaattgaaaa ttactcccgg cctcggcccg
     7381 tcccatgaat tccgcagcct cattttccac ccctccggag gaggaaggac catgcggcga
     7441 ctggacttat catgaatggg ccgaggcttt ttccaccaat gacctggccc gctccctgcc
     7501 cccggggcat attgccgtct gccgcgttca gacaggaggc cgcggcaggt tcaaccgcaa
     7561 atggataggg gaggaaggcg gcctgtgggc atccttcacc gttcccctgt ccgctcctgc
     7621 ggatacagcg gccggcgtgc actggggcca tttgcccctg gttgcggggc tggccctgtt
     7681 caacatgctc cgcggcatgg ggctggattc cgtgcgcctg cgctggccga acgacctgct
     7741 ggcgggcaaa tccaaactgg cgggaatact ggtggaacgc ccggcggaaa acatggccgt
     7801 catcggcatc ggcatcaatg ttttcaatga tgtagcctcc atcgccgggg aaatcaagga
     7861 ccctccggca aggctggcgg atcttgttcg ggactgccct tccctgcacg ccgtcatggc
     7921 ttccctgggc agtcatttga accaggttct ttccgtcttt tcccacggcg gcgtctctgc
     7981 ccttcaggag ggtctgtccc gggcatgggc cggagaaagg ccggtttcca ttcttacgga
     8041 tgacgaaacc gtccggggta tttttacagg gattgacgat cagggcaatc ctgtgctatc
     8101 ccttccggcc ggcgccgtcc gcaccattcc ggcgcacctg attaacaggc tcctcgaaga
     8161 atgagcctgc cgctccgttt ttacacgggg tttctttctt ttttcatcca acaaaaatca
     8221 ctgacatgag ttacaaggta ctgacaccag aagaagcagc aagcctgatc aagcatggcc
     8281 accatattgg gctgagcgga ttcacgcccg ccggaacggc caaggccgtt acggccgcgc
     8341 tggcaaaaat cgcagaagcg gaacatgaga aggggaaccc tttccaggtg agcgtcttca
     8401 ccggtgcttc caccggcgat tcctgcgacg ggatcctttc ccgggccaag gcaatccgct
     8461 accgcgctcc ctacaccacc aacgttgatt tccgcaaggc ggtgaacaac ggggaaatcg
     8521 cctataatga catccatttg tcccagatgg cccaggaagt gcgctacggg ttcatgggca
     8581 acgtggacat cgccattatt gaagcctgtg aagtcacggc cgacggcaaa atttacctga
     8641 cggccgcggg cgggatcgct cccaccatct gccgcctggc agacaaaatt atcgtggaat
     8701 taaacgccgc ccacagcaag agcgccatgg gcctgcacga cgtttacgaa cccctggatc
     8761 ctccctaccg ccgcgaaatc tccatcttca aacccagcga ccgcatcggc aagccgtaca
     8821 tccaggttga cccgaaaaag attgtgggcg ttgtggaaac caactggccg gatgaagccc
     8881 gttccttcgc cgcagcggat cccctgactg ataaaatcgg gcagaacgtg gccgatttcc
     8941 tggctgccga catgaaacgg ggcatcattc cctccacatt cctgcctctc cagtccggcg
     9001 taggcaacat cgcaaacgcg gtgctgggcg ccctgggccg cgacaagacg attcccgcgt
     9061 tcgagatgta cacggaagtc atccagaact ccgtcatcgg cctgattcgg gaaggccgcg
     9121 tgaaattcgg cagcgcctgc tccctgaccg tgacgaacga ctgcctggaa ggcatttaca
     9181 gggatatgga ctttttccgc gacaaactgg tgctccgtcc ctcggaaata tccaacagcc
     9241 cggaagttat ccgccgtctc ggcgtcatct ccatcaacac cgccattgaa gccgacattt
     9301 acgggaacgt caactccacg cacattggcg gcacgaagat gatgaacggc atcggcgggt
     9361 ccggcgactt cacgcgcaac gcctacatct ccattttcac ctgcccgtcc gttgccaagg
     9421 acggcaagat cagcgccatc gtccccatgg tttcccacca tgaccatacg gaacatgacg
     9481 tcaatatcat tattaccgag cagggggtcg cggacctgcg cggcaagagc ccgaaagaac
     9541 gggcccagac cattattgaa aactgcgtcc acccggatta caaaaacatc ctctgggatt
     9601 acctgaagct gtccgacggc aaagcccaga cgccgcaatc catcagggcc gctttgggca
     9661 tgcacgccga actggccaga agcggagaca tgaagaatgt cgactgggcc cagtataagt
     9721 aattccgcat gccgtcactc gcattggcat ccatgaattc acgttaaccc ctcaggaccg
     9781 cttccgcaaa gggagcggtc cttttccttt ttcccatccc ctctactcct tttcttcacc
     9841 atgaactgga tgatttaccc ggcagccagg gctttcatca aagtctgcgc cgttcttttc
     9901 ggcgcgggcg caacagcagc agccctcatc catctgttca tgcctttttt cctccgctct
     9961 ccccggacag ccgcgccctt cctgcttttg ggaacagggg cggaattgct ctccatcctt
    10021 tccctgtcct tcctcatgtt ctggggcgcc agagttctgc tggcctcccg gggaagcaag
    10081 ataacaagaa atctgagcat gctggccttc ctgcccgccc tgtacgccct cctcattccg
    10141 tttgcgggca tgcccgcctc atcgcaatat acggaaatgg acagggtttg ggaggccttc
    10201 ctccttctgg cgtccgtcat ttctttcttt tccttccctt atacggcggg atacggcgcc
    10261 gcaggcagga gattattcct ggcctggggc atctcggcgg caggatgcgg tttgcagagc
    10321 gccctgtttt ttcttgccgt cctgttgcgt caattcctga ccacagcagt tccctccctg
    10381 gcagcgccag ttgcatggct ggccgttctt ttgtcctgcg gcctggaaat catgctggcg
    10441 gccctttccg tcattctggc gcggcgcctg tttaaagagg tcatgtccat agcgtccatg
    10501 ccggaatcga ttgatccctc catgccgggc aaccttccct gacttccccc ctgccttcat
    10561 gtttgcagcc agttggaagg ggttaccccc agtccgcggc atgaatacgc gaaccgctca
    10621 cggcagcctt cttccaaccc ggctgccgca tcccggcatg aaaggctttt acggctttgc
    10681 gcaaaaagcc gtccggaaat ttccgccggt ggaacggaat ccgtatggaa agcattgccg
    10741 gaaagcaacc cgccccaccc cggaaagccg cgggttcgca ggaacacccc tcccgtttcc
    10801 acgccggcgg cagacagccc tatttcacca attcatccag ataacggcca taaccgttat
    10861 tattcatggc tccggcctgg gagcgcagcg tttcctggga aatccagccg ttattaaagg
    10921 ctatctcctc caggcaggct accttgaacc cctggtggtg ctccagagta cgaacgaaca
    10981 tggaagcctc cagaagggta tcgtgcgtgc ccgtatccag ccacgtataa ccgcgcgcca
    11041 gtttttccac gcgcaacagg ccctgcttca ggtattcctg attcacagag gtgatttcca
    11101 actcgccgcg ggaagacttg ggaatccgtt tggctatctc caccacccgg ttgtcgtaaa
    11161 aatagaggcc cgtcaccgca atatccgatt tgggcctgag cggtttttcc tcaatggaaa
    11221 ccgccttccc ctcctcattg aattccacta ccccgaaacg ctgcgggtca tgcacctggt
    11281 aaccgaaaat ggtcgctccg ctcgtcagtt cggcggcccg cctcagcttc tccgtcaggc
    11341 cgcgcccgta aaaaatattg tcccccagca ccagggcaac ggaatccttt cctatgaact
    11401 cctctccaat aataaaggcc tgagccagcc cctccggcct gggttgttcc ctgtattcaa
    11461 aggaaacgcc gaacctgctg ccgtccccca gcaaatcccg gtacaggggc agatcccggg
    11521 gcgtggaaat aacaaggatt tcccgtattc cggccagcat cagcacagag atgggataat
    11581 aaaccatcgg cttatcataa acgggcagca attgcttgct gacggaaagc gtaacgggat
    11641 gcagacgcgt gccgcttccc ccggccagaa caataccctt catatcaaat tcctagccat
    11701 tggttccaag acgttccagg cggtattccc cggacaggat gccccgccac cattcctcat
    11761 ggtccagata ccactgaatg gtctttctga atccggaaga atggtcctgg cgcggagtcc
    11821 accccaattc cctccgtatt ttggaagcgt caatcgcata gcgcaggtca tgacccggcc
    11881 tgtcctgcac aaaggagatt tgctcccggt agctccggcc gtccggccgg ggccgcagtt
    11941 catccagatg ggaacacagc agctccacca gctccagatt ggttttctcg ttattgccgc
    12001 cgatgttgta cgtttccccc ggttttccgc aggaaacgac cgtcaacaga gcctcgcagt
    12061 gatcccccac atacagccag tccctcacgt tttccccttt gccgtataca gggatggggg
    12121 ccccgcccag cgctttcagg ataacgacgg ggatcagctt ttccgggaac tggtaagggc
    12181 cgtaattgtt ggaacagttg gtgatcagca cgggcagtcc gtacgtatcg tgccaggcgc
    12241 gcaccaggtg gtcgctggag gccttgctgg cggaatacgg ggaatggggg cgatacggcg
    12301 tggactccgt gaacaggcct tcctttccca gggagccgta cacttcatcc gtggaaatgt
    12361 ggtggaagcg gaaacgctcc tttttctctc cctccaggga acggtaatat tccagggcgg
    12421 actgaagcat ggaaaaagtg cccatgacgt tggtggtcat aaaatttccc ggatcgtcaa
    12481 tggaacggtc cacatgggat tccgccgcca ggtgcatcac ccagtccgga gcgtactccc
    12541 gcaaagtgcg ccgcatcagg gaagcgtccc ggacgtcggc gtgcagaaag aggtatgccg
    12601 gagaatccgc cgagccgtcc agtgaatgga tgttgccggc ataggtcagg gcgtcaatat
    12661 tcaggacttc atggccgcgc tccagcagca gcctgaccag attggagccg atgaatccgg
    12721 cgccgcccgt aacgataact ttcatagcac tgttttcagg gaaagatgcg gcgccatcat
    12781 acagcagcgg cgtttttttt caaaacaaat ccgcccatgc cgcgggaacg tggcggcatg
    12841 ggcgggaaaa agcgggttcc gtaaccgctg agacggctag cagctcagct cccgacaaag
    12901 gttgatgata tcctggttca cggagtactg ctgcccggct acggaatcca gggaggcata
    12961 gccgtactgg ccgtcatgat acaccatgat ctggttgatg tccccgttgt tcagagcttc
    13021 cacggcgcgg gtggcaaaac gggtgcccat caggcggtca cgggcggtgg gggaaccgcc
    13081 gcgctgcaca tggcccagca cggtcaggcg ggtatccatg ccggcgcgtt ccgtcagcca
    13141 gcgggtcagg tactgcgcca cgcgggtgcc ttccgccacc acggcaatga tgcagcttcc
    13201 ttcctcattg atgacaggct ggaggcgctt gtaaatggat tccaggtcat acggaatttc
    13261 agggacaatg cagatatccg ccgcgctgca aagagcggtg gtcatcgcca gatagccgca
    13321 gtcccggccc atcgtttcaa tcacgaaagc gcggtgatgg gaacgggccg tatcacgaac
    13381 ggaatcaatg caatccagaa tcacgttctg ggccgtatcc acgcccaggc agtagtccgt
    13441 gccggcaatg tcgttgtcaa tcgtggccgg aataccggca aaaggcactt caaaatcatt
    13501 gaaaaagtcg ttcagggcgc ggaaggaacc gtccccgccc atgatgatga gcttgtcgat
    13561 gttgcgtttc ttcagatgtt cgtaggcctg cttgcggaat tcgtagtcga aaaagcgctt
    13621 ggatcgtgag gaacggagga gagttccgcc cctgtagatc atatcgttgg tcagttcccg
    13681 ggtggcttcc ttgatttttc catcgatcag cccttccaag ccgtcataaa caacgtacgg
    13741 gttcatccca agctggcggg catgatccac tgccgccttg atcgccgggt tcattccggc
    13801 ggcatcaccg ccagatgtca taatggctat tccactcata agtaataagg ttaacttgtc
    13861 cggggggaaa tgttaccggg cggaacaaat aatgcaagcg cggagttttt actggcgcaa
    13921 taaacggcaa cacttcatga tgcggaggca tgaacgacac tgcagcagcc attctgaaag
    13981 ccacggccgc cctccgggac ggcacggaga agctccggtt cgaatccccg gtccatgtta
    14041 cctacaaccc tctcacctat gcatgggggc cgcatgaaca gtatgtgcgc acctacggaa
    14101 acggggaaaa gggccatctg ttcctgggca tgaatcccgg ccccttcggc atggcccaga
    14161 caggcgtccc tttcggggaa gtggacgccg tcgtcaactg gctgcacatc cgcggagaag
    14221 tcggacggcc ggaacatacc caccccaaac gtcccgtgga gggtttcggc tgccccaggt
    14281 cggaagtcag cggccgccgc ctctggggac ttttcgcgga agctttcggc actgcggaaa
    14341 acttcttccg tcacaattac gtggccaatt actgtccgct gatctggatg ggagccaccg
    14401 gagccaacat tacgccggac aaactgccgg cggaacagcg cgccgccgtg gacgcagtat
    14461 gcatggaaca cctgctttcc ctcatcacca tcctgaatcc ccacacgctg gtgggtgtgg
    14521 gtgcctacgc cacgcagaag ctgcgggacg ccgcctcccg gctccccggc aaaagcttca
    14581 ccatcggcac gttgctccac ccaagccccg ccagccccat cgccaacaag ctctggccgg
    14641 aacgccccat ccagcagctt aaggaactgg gcattttata aaaagagcgg aggaggtaga
    14701 gtggaaagct ccgtgacatg gaaggaatca ccagagcgac aggccggaaa tcggcagttc
    14761 atcttgttcc cctccaaaac tacatcgctt tgaaggaata tccggccccc ttcactggct
    14821 tgattcgccc agggacacgg ccttcctgac ggaagaaatg cacgccggca tctaccggga
    14881 cggagaagaa cttaaa
//
