LOCUS       c00058_gnlPro..        17360 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LCPDDLMG_58.
ACCESSION   c00058_gnlPro..
VERSION     c00058_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 08:08:34
            Original ID  :: gnl|Prokka|LCPDDLMG_58
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17360
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17360
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3814:7360](-)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(3815..7360)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..17360
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..17360
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             399..1175
                     /locus_tag="ctg58_1"
                     /transl_table=11
                     /translation="MKKLFFIMAMSVCAFMAQAQTTSGIRVGLNMTSATGKYNDLMADQ
                     DYNNKSYMGYSVHYFIDVPVIGNFSIQPAIGLSMKGITYEYDKFTTKKSHRVDLDSYKK
                     YDVTESRGTSVTQKHNLGYLDVPILFAYALPLSESFRVQLGVGPYFSYGLFGKFKYESD
                     TYLTVSPDKYGENKHTITKDDCPSFGKNDDGDDPKGNINRFDWGIAIQGSIYWKRLFLN
                     VAYQKGLKSANITDEKNEGKDKLALSNLSLGLGFIF"
     CDS             complement(1661..2083)
                     /locus_tag="ctg58_2"
                     /transl_table=11
                     /translation="MYVVQRDRLQLSHFFLQQSFIILLSLLSPIPCNPYKQEVREVVAA
                     HYFMYKNAYCHHFIHLVTWYKPTLFVHQTGQACAMNTIGLYGEHGKLVQPRNNDFPCQS
                     IQNLDTSSVGSCSKFHEILYQVLPLHPASFPFGGEG"
     CDS             complement(2083..3600)
                     /locus_tag="ctg58_3"
                     /transl_table=11
                     /translation="MNTLTNLKYTLAVTAGLCSSFAYAQNHPHIILIMTDQQRADAIGC
                     MGNDAVISPNLDALAAEGTLFMNGYSSCPSSTPARAGLLTGLSPWHHGLLGYGKVSPEY
                     KYEMPQMLKDAGYYTFGIGKMHWHPQRVKHGFEGTLLDESGRVEDENFTSDYRQWFQTK
                     APGKNPDATGIGWNDHTASIYKLPENLHPTYWTGEMACELISNYDPTNKPLFLKVSFAR
                     PHSPYDPPQRYLDMYEDALIPDPAIGDWCGKYAKKLNPEKTAQDAPYGNFGNEYARNSR
                     RHYYANITFIDEQIGRIIQTLKEKDMYNDALIVFISDHGDMMGDHYHWRKTYPYEGSTH
                     VPYIVKWPSVDHVTPGKTDAPVELRDILPTFLDAADVTIPTDMDGRSLLPLAKGMETTW
                     RKYLDLEHATCYSDDNYWCALTDGKIKYIWRIHTGTEELFDLTQDPQELHNAVNDKKYR
                     KQLTEMRNEMIRHLSERGEEFVKDGRLVVKEKTMLYGPNYPGKENKR"
     CDS             complement(3815..7360)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg58_4"
                     /sec_met_domain="PFOR_II (E-value: 4.7e-19, bitscore: 59.7,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 2.6e-83, bitscore: 270.2,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 1.8e-31, bitscore: 100.5,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.5e-12, bitscore:
                     38.6, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 1.2e-12, bitscore: 39.7,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.2e-07, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 6.8e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 4.3e-26, bitscore: 81.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSCRQTGFAMLCEGSVQEVMDMAAVAHLATI
                     KSRVPFVNFFDGFRTSHEIQKIEMLENEDLAGLIDQQALAEFRQRALNPNNPVARGMAE
                     NPDHFFQHRESCNNFYEAVPAIVEEYMNEISKITGRPHGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDYLMSKGEKVGLVSVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGTENAPVIVGGRYGLGSKDTTPAQIIAVFKNLALPMPKNHFTVGIVDD
                     VTFTSLPQEEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNITVYYINATQIAQEIGLGNRTNTILQSAFFRITGVIPV
                     DLAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKQLAVDPAWANLEVEAPAANNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWEQGTAQYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGANFETLKAVGKQFDGMTFRIQVDVLDCLGCGNCADV
                     CPGNPKKGGKALTMKHLESQLSQAANWEYCAKNVKSKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTKNEKGQGPAWANS
                     LFEDFCEFGLGMTLADKKLRARIEAAMKDAIASDTCPAEYKEAFQEWIDGKDDADKSKA
                     AAEKIIPMVEAAKDKCKNCAIIAEFKNYLVKKSQWIIGGDGASYDIGYGGLDHVIASGE
                     DVNILVLDTEVYSNTGGQSSKATPLGAIAKFAASGKRVRKKDLGMIATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLVIAYAPCINHGLKAGMGKSQAEEAKAVECGYWHLWR
                     FNPALEEEGKNPFMLDSKEPKWEGFQDFLKNEVRFASVMKQYPAEAADLFAACEEMAKK
                     RYASYKRMEAMNWSE"
     CDS             complement(7403..8581)
                     /locus_tag="ctg58_5"
                     /transl_table=11
                     /translation="METFYRTHSYLVEHTNAPVRRDLMDEIDWNDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGTDHSCLFINMNNFYFSKYTLVEFAAEFVKRGGKVLLIDQVFKYPEWS
                     HDLRACYEMFPTLKIIFTGSSVMRLKEENPELSGIVKVYYLRGFSFREYLNLQSGNCFR
                     AYTLQEILENHEQIAKTILRNVKPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMIE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPVAPNVSQLATEIQTSRATVMNYIKYLADAR
                     LINMVYPKGEEFPKKPSKLMMHNTNLMYSIYPVKVEEQDVLDTFFMNTLYKDHKLYKGD
                     KGTSFMVDNGLHFRICAEGCKFKNNPNVYYALHKLELGHGNMIPLWLFGFLY"
     CDS             8724..9896
                     /locus_tag="ctg58_6"
                     /transl_table=11
                     /translation="MEALYLFNPENDMALACGDPYYMAPASARRMAAELSMLPAWYAEE
                     GGTVWLDSAQRMKTMERQSFLPLSVNWVLEFVPIYNKVIPWGWNPSLVRRLQEAGFPDT
                     AYPSVERMKRIRQISGRQTAVKVLRRLCRHIGGNIPILGEAFVLSSIEEVKAFVLSHSR
                     ALLKAPWSGSGRGIQYVSGSFPIPLEGWIRHILTTQHEVIGEPFYDKLLDFAMEFFADE
                     WGQVHFIGYSLFETDKRGVYKENLLAADRVIEARISTYVSAEILHQVGRALQVELAEVI
                     KGSYEGYLGVDMMVCRTQNSGYAIHPCVEINLRMNMGVVARLIYDNYVCDGVQGRYVIE
                     YYAKPGEAWHSHLALQEKYPLYLENGKVKSGYLSLTPVENNTSYQAYILI"
     CDS             complement(9935..11308)
                     /locus_tag="ctg58_7"
                     /transl_table=11
                     /translation="MMKHTLLYIAVSGMTLLTSCQLGKHYTRPDLHLPQQLDTLRQQDT
                     LSIADMQWWEIYTDTTLQSLIEKTLDNNKDMKIAAARVKELAAMKRIDFANLFPQLNGG
                     AYAQKEGSNYGGNNYKNDPELGGKLTVTWELDLWGNLRWAKDKSIAQFLGSIEAQRALK
                     MSIVSEVAQAYFELVALDNELNIVRQTLYARKEGVRLAKLRFEGGLTSETSYQQAQVEY
                     ARTATLVPELERKISLKENDIAFLAGEYPHRIQRSILPEEVKLPETLPVGLPSTLLERR
                     PDVREAEQKLIAANASVGIAYTNMFPRLSLTAQYGVESEEFSDFFKSPIHYISGNLLTP
                     LFAMGKYRATLKAKKAAYEQECYSYEKSVLTAFKEARNAIVDFNKIKDIYESRLQLERS
                     SKATMELAQLQYINGVIGYLDVLDAQRSYFDAQIGLSNAIRDKQITLVKLYKALGGGW"
     CDS             complement(11330..14344)
                     /gene_functions="resistance (resist) RND_efflux (Score:
                     957.9; E-value: 4.6e-290)"
                     /gene_kind="resistance"
                     /locus_tag="ctg58_8"
                     /transl_table=11
                     /translation="MLPIDQYPQITPPVVKISASYPGASALTVSQAVATPIEQELNGTP
                     GMLYMESNSSNSGGFSATVTFDISADPDLAAVEIQNRIKLAESRLPAEVIQNGISVEKQ
                     AASQLLTLCLTSTDPKFDEIYLSNFATLNVLDLIRRIPGVGRVSNIGSRYYAMQIWVQP
                     DKLANFGLTVADLQNALKDQNRESAAGVLGQQPVQGLDVTIPITTQGRLSTVSQFEEIV
                     VRANADGSIIRLRDVARISLEAQSYNTESAINKENAAVLAIYMLPGANAMEVAKSVKEA
                     MEEISKNFPEGMSYEIPFDMTTYISESIHEVYKTLFEALILVIIVVYLSLQSWRATVIP
                     LVAVPISLIGTFGFMLIFGFSLNILTLLGLVLAIGIVVDDAIVVVENVERIMEEEKLSP
                     YQATKKAMEGLTGAIIATSLVLAAVFVPVSFLGGITGQLYRQFTVTIVVSVLLSTVVAL
                     TLSPVMCSLILKPEDPNKKKNIIFRRINKWLAIGNHKYVGLIKHIVKHPRRVLSTFGMV
                     LIAILLIHRIIPTSFLPIEDQGYFKIELELPEGATLERTRIVTERAVEYLMENPAVEYV
                     QSVAGSSPRVGTSQARSELTIILKPWEERDSQTIDDIMAQVKKDMSQYPECKVYLSTPP
                     VIPGLGSSGGFEMQLEARGDATFENLVQATDTLMYYASKRKELSGLSSALQADIPQLYF
                     DVDRDKVKFAGVPLADVFSTMKAYTGSVYVNDFNMFNRIYRVYIQAEAPYREHKENINL
                     FFVRGTDNAMIPLTSLGTTSYTTGPGSIKRFNMFNSSVIRGEAADGYSSGQAMEIIEQI
                     AREHLPENIGVEWSGLSFQEKQAGGQTGMVLALVFMFVFLFLAALYESWMVPVAVLLSL
                     PVAALGAYLGVWGCGLENDVYFQIGLVMLVGLAAKNAILIVEFAKEQVDRGIDVVQAAL
                     HASQLRFRPILMTSLAFILGMLPMVIASGPGSASRQAIGTGVFFGMIFAVTVGILLVPF
                     FFVLIYKMKAKMKQK"
     CDS             complement(14498..15697)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg58_9"
                     /sec_met_domain="Biotin_lipoyl_2 (E-value: 1.2e-08,
                     bitscore: 25.7, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLFFTHKEIALKKKRTALVVIGIGLVIGIYLIVSHQPAKMPELP
                     VVAIAPATQDDVEIYGEYVGRVRAQQFVEVRARVEGYLEQMLFAEGTYVTKNQVLFVIN
                     QDQYRAKADKARAQLKKDEAQAQKAKRDLERIRPLYEQNAASQLDLDNATAAYETAEAS
                     VAMSSADLDQAELELGYTIVRSPLAGHISERHVDLGTLVGPGGKSLLATIVKSDTVLVD
                     FSMTALDYLKSKERNVNLGQKDSTRSWQPNVSITLADNTIYPYKGLVDFAEPQVDPRTG
                     TFSVRAEMPNPERVLLPGQFTKVKLLLDVRESATVVPLKSVIIEKGGAYIYVMRKDSTV
                     ERRFIELGPEFQNQVVVERGLAPGEDIVIEGYHKLNPGMKVKVSPAVEDKKTEEEDTIG
                     "
ORIGIN
        1 attgtatata tagtcgttaa ttttagctgc ttggtatcta ttttagtgtg tttagtgtaa
       61 atcttgacaa atgatagttt tttgaatata aaagttgcaa tacatttgca aatgtaaact
      121 tatagagtca attgttacga agtatggaaa agacaattat tgcagcattt taatgctaat
      181 ttcgttaaca tcgtatgcac agggtttaat gtggaatgcg aaggctgctc aatatgagca
      241 gcatgtctag cgtagaggaa tctaaaatgc atccaggttt ctatgcagga ataggagctg
      301 agtatgctat tgatgaaaat tggtctgtcc gtctttcttt attgttcact atgaaaggag
      361 tgaaacaaga ttacaaattt taataaaaat actgcattat gaagaaactg ttttttatca
      421 tggctatgtc cgtatgtgca tttatggcac aagcacaaac tacttccggt attcgcgtgg
      481 ggttaaatat gaccagtgct acagggaagt ataatgatct tatggcagat caagattata
      541 ataataaaag ctatatgggt tacagtgtcc attattttat agatgttcct gtgattggca
      601 actttagtat tcagcctgct attggacttt ctatgaaagg tatcacttat gaatatgata
      661 aatttactac taaaaaatcg catcgggtcg atttggattc ttataagaaa tatgatgtga
      721 cagaatctcg cggcactagt gtcactcaaa aacataatct gggctatttg gacgttccta
      781 ttttatttgc ttatgcttta cctttgtcag aatcgtttag ggttcagttg ggagtgggcc
      841 cttacttctc ttatgggctg tttggtaagt ttaaatatga gtcggataca tatttgacag
      901 tatcccccga caaatatgga gaaaataaac ataccataac caaagatgat tgtccctcct
      961 ttggcaagaa tgatgatggg gacgatccta aaggtaatat taaccgtttt gactggggaa
     1021 ttgccataca gggcagcatc tattggaagc gcttgttttt gaatgttgct tatcaaaaag
     1081 gtctgaaatc ggctaatatt actgacgaga agaatgaagg gaaagataaa ttggctcttt
     1141 ccaatttgtc gttagggtta ggctttatat tttaatttgt gaacagactg caggaactgt
     1201 tggaaaatag aaagatagag gggcttcaga aatttgatga aactcgtgca tcctttcttg
     1261 ctgaaatgaa gaatctgtcg ggtgaaatgg aggttcactt ggaaactcat tttcttgttt
     1321 ttagagataa agcggtgtga atttgatgtt ccatcgcttt tcctatgcta ttggaatgag
     1381 ctctgattag cttgcccgat aagttatgga aaagggaatt tggtttcggg gtcagtcatt
     1441 atagcaagca ggtggcagga tattttttta cacgtacata catatgtgta gaaatctgtt
     1501 tccggtcaca gtcccgtatc gttccgaaag cctttattct tttcggaaaa aacaaggatg
     1561 tttgcaaaaa agatgaagac gtctgataaa aagaacaaga cgtttcgttt caaagatcta
     1621 tatcttccaa cctttagttt aagtctttcc ggctaccggt ttatccttct cctccgaaag
     1681 ggaaggatgc tgggtgtaac ggcaaaactt ggtacaggat ttcgtggaac ttgctgcagg
     1741 atccgacaga acttgtatca agattctgaa tactttggca aggaaagtcg ttgtttcgag
     1801 gctgcacaag tttaccgtgt tcaccgtaca agcctatcgt gttcattgca caggcttgtc
     1861 ctgtctggtg gacaaacaaa gtaggtttgt accatgtaac aaggtggata aagtggtggc
     1921 agtaggcatt tttgtacata aaataatgtg ctgccaccac ctctctaact tcctgtttat
     1981 aggggttgca gggaataggt gacaacagtg acagcagaat tataaaactc tgttgtagga
     2041 aaaagtggga caattggaga cgatccctct gtacaacgta cattatcttt tattttcttt
     2101 ccccggataa ttaggtccat aaagcatggt cttctccttg accaccaatc gaccgtcctt
     2161 cacgaactct tcgccgcgtt cacttaaatg acggatcatt tcattacgca tttccgtcag
     2221 ctgcttcctg tattttttgt cattgacggc attgtgcaat tcctgagggt cttgggttaa
     2281 gtcgaataac tcttcggtac cggtgtggat acgccatata tattttattt tgccgtcagt
     2341 cagtgcgcac caatagttgt catcactgta acaggtggca tgctctagat ccagatactt
     2401 gcgccaggtt gtttccatgc ctttggcaag tggcaacaaa gaacggccgt ccatgtcagt
     2461 ggggatggtc acatcggctg catcaaggaa agtgggaaga atatcacgta actctacagg
     2521 agcgtctgtt tttcccggtg taacgtggtc gacggaaggc catttcacga tgtatggcac
     2581 atgagtggag ccctcgtatg gataagtctt tctccagtga taatggtcgc ccatcatatc
     2641 gccatgatcg gaaatgaaaa cgattaatgc gtcattatac atatcctttt ctttcaatgt
     2701 ttggataatt ctgcctatct gttcgtcaat gaaagtgatg ttggcataat aatgacgtct
     2761 ggaattgcgt gcatattcat tgccaaaatt accgtatgga gcatcttgtg ccgtcttttc
     2821 aggatttagt ttttttgcgt atttgccaca ccagtctccg atagcaggat cgggtattag
     2881 ggcatcctca tacatgtcca gatatctttg tggtggatca tacggactgt gtggacgggc
     2941 aaaagaaact ttcagaaata acggtttgtt ggtcggatcg tagttgctga taagttcaca
     3001 ggccatttct cctgtccaat aggtaggatg gaggttttcg ggcaatttat atatacttgc
     3061 cgtatggtcg ttccagccta taccggtggc gtcaggattc tttccgggag cttttgtttg
     3121 gaaccattgg cggtaatcac tggtgaagtt ctcgtcttcc acgcgtccgc tttcatctag
     3181 cagagtgcct tcgaaaccat gttttacccg ttggggatgc cagtgcattt tcccgattcc
     3241 aaaagtataa taaccagcgt cttttagcat ctgtggcatt tcgtatttat attcgggaga
     3301 tacttttcca tatcccaaca agccatgatg ccaaggagaa agtccggtca gcagaccagc
     3361 acgtgccgga gtgctgcttg gacaagaaga atagccattc ataaataatg ttccctcggc
     3421 agctagtgcg tctaggttag gggagataac agcatcgttt cccatacagc ctatggcatc
     3481 ggctcgctgt tggtctgtca ttatcagtat gatatgagga tggttttgtg cgtatgcaaa
     3541 agaggagcac agtccggctg tgacagccaa tgtgtatttc aggttggtta gagtattcat
     3601 gtttataggt ttttcataat gttatgtggc aaaggtagga aatttttggt aaccttaagc
     3661 cataaatagt gatggtaaaa gtagaaatat ttgaaattga ggtcttattt tgtgcatacg
     3721 tatgcgtggc ctcatatata ctaatggtag aaaaaggtta taaaaaaggc ttgttcttca
     3781 tgaacaagcc ttttttatat gcatgtatta gaaattattc actccaattc attgcttcca
     3841 tacgtttgta agaagcataa cgtttcttgg ccatttcttc gcaagcagca aacagatcag
     3901 cagcttcagc aggatactgc ttcattacag aggcaaaacg aacttcgttc ttcaagaaat
     3961 cctggaaacc ttcccatttc ggttctttag agtcaagcat gaatggattc ttgccttctt
     4021 cttccaaagc agggttgaaa cgccataagt gccagtaacc gcattctaca gccttagcct
     4081 cttcagcctg gctcttaccc atacctgcct tcaaaccgtg gttgatacac ggagcgtaag
     4141 cgataaccaa tgacggaccg ggataagctt ctgcttcacg gatagctttc aaagtctgag
     4201 cttggtcagc acccatagca atctgggcaa catatacata accgtaagta gtagcgatca
     4261 taccaaggtc tttcttacgt acacgcttac ctgaagcggc aaacttagcg atagcaccca
     4321 gcggagtagc cttagatgac tgaccaccag tattagagta aacttcagta tccaatacca
     4381 aaatatttac atcttcgccg gaagcaatca catggtccaa accaccgtaa ccgatatcgt
     4441 aagaagcacc gtcaccaccg ataatccatt ggctcttctt aaccaaataa ttcttgaatt
     4501 ctgcaatgat agcgcagttc ttacatttat ctttagcagc ttccaccatt ggaatgatct
     4561 tttcggcagc ggctttgctc ttgtctgcat cgtccttacc atcaatccat tcctggaatg
     4621 cttctttgta ttctgctgga caagtatcac tggcgatagc atccttcata gcagcttcga
     4681 tacgtgcacg aagtttcttg tcagccaaag tcatacccaa accgaattcg cagaaatctt
     4741 cgaacaatga gttagcccaa gcaggacctt gacccttttc gttcttagta taaggagttg
     4801 aaggaacaga accagagtag atagaagaac atccggtagc gttagcaacc atttcacggt
     4861 caccgaataa ctgggaaatc agtttcacat atggagtttc accacaacct gaacaagctc
     4921 cagagaattc gaacaacgga gtagcgaact gagagttctt cacattggct ttgatatcta
     4981 ctaaatgttg tttgctcttc acgttcttag cgcagtattc ccaattggct gcttgagaca
     5041 actggctttc caaatgtttc attgtaagag ccttgcctcc cttcttcgga ttgcccggac
     5101 aaacatcagc acagttacca caacccagac agtcaagcac gtcaacctgg atacggaatg
     5161 tcattccgtc aaattgttta cctacagctt tcaatgtctc gaagtttgca cccttttgtt
     5221 cttcagcgtc aagtacgaac ggacggatag aagcatgagg acaaacatat gcacacttgt
     5281 tacactggat acagttttca gcattccatt caggtacgaa tgcagctaca ccacgttttt
     5341 cgtattgagc agtaccttgt tcccaagtac cgtcttcgat gcctttgaat gcagataccg
     5401 gcaacaagtc accatcctga gcgttgatag gacgaactac ttcgttgatg aatgcagggt
     5461 cattgttagc agcaggagct tcaacttcca gattagccca agccggatca acagccaatt
     5521 gtttgtattc gccaccacgg tctacggcag catagttctt gttcaccacg tcttcgccct
     5581 tcttgccata agacttaacg atgaatttct tcatctgttc tacagccaag tcaacaggaa
     5641 taacgcctgt gatacggaag aatgctgatt gcaggatggt attggtacgg ttgcccaaac
     5701 cgatttcctg agcaatctga gttgcattga tatagtaaac agtaatgttg ttttgtgcga
     5761 aatatttctt aaccttgttc ggtaagttct tggccagttc ttcaccttcc caaatagtgt
     5821 tcaacaagaa agaaccgttc ttacgtaaac cacgagttac atcgtacatg tgcaaataag
     5881 cttgtacgtg gcaagctacg aagttcggag tatttactaa ataagtagaa cggataggag
     5941 tatcgccgaa acggaggtga gagcaagtga aaccaccaga tttcttagag tcgtatgaga
     6001 aataagcctg acagtgcttg tcggtgttgt caccgataat tttcactgag ttcttgttag
     6061 cacctacagt accgtcagca cctaatccgt agaatttagc ttcaaacata ccttcgccgc
     6121 ctaatgcgat ttcttcttct tgaggaagag aagtgaaagt tacatcgtct acgataccca
     6181 cagtgaagtg gtttttcggc attggcagag ccaaattctt gaatacagcg atgatttgag
     6241 caggagtagt gtctttagaa cctaaaccgt aacgtccacc tacgataacc ggagcgtttt
     6301 ctgttccata gaagcagtct ttaacatcca gatacaaagg ttcgccgttt gctcccggtt
     6361 ctttagtacg gtcaagaact gcgatagtct tggcagtctt aggtacagca gccaagaaat
     6421 gtttagcaga gaacggacgg tataaatgta cagaaaccaa acctactttt tcacctttgc
     6481 tcatcaagta gtcgatagct tcgcgggcag cttctgtaac agaacccatt gcgataatta
     6541 cgcgttcagc gtcttcagca ccatagtaat cgaacaaacc atgagggcgg cctgtgattt
     6601 tgctgatttc gttcatgtat tcttctacga tagccggaac tgcttcatag aagttattgc
     6661 aagattctct gtgctggaag aagtggtcgg ggttttcagc cataccgcgt gcaacagggt
     6721 tgttaggatt caacgcgcgt tgacggaatt ctgccaaagc ctgttgatca atcagacctg
     6781 ccagatcttc attctccagc atttcaattt tttggatttc gtgagaagta cggaaaccat
     6841 cgaagaagtt gacgaatggc acgcgagatt tgatagtagc aagatgagct acagcagcca
     6901 tatccataac ttcttgtaca gaaccttcgc acaacatggc gaaacctgtt tggcggcaag
     6961 acatgacgtc ctgatggtca ccaaagatac acaatgcgtg tgaagccaat gtacgagccg
     7021 atacgtggaa tacgcaaggc aggaattcac cggcaatttt gtacatgtta gggatcatca
     7081 gcaacagacc ctgagatgca gtgtaagtgg tagtcaacgc acctgcctga agagaaccat
     7141 gaacagcacc tgctgcaccg ccttctgact gcatttcttg taccaaaact gtttcgccga
     7201 agatgttttt acgacctgcg gcagcccatt cgtctacgta ttcagccata gtagacgacg
     7261 gagtgatggg atagatagca gctacttcag agaacatata cgagatatgt gctgctgcct
     7321 ggttaccatc acaagtgatg aatttttttt gtttagtcat acaattacta attattaggt
     7381 aataaaatct attctctatc tcttaatata aaaagccgaa aagccataat gggatcatat
     7441 ttccgtgtcc taattccaat ttgtgtaggg cataatacac gtttggatta tttttgaact
     7501 tgcacccttc tgcgcaaata cggaaatgca gtccgttgtc taccataaat gaagtgcctt
     7561 tatcgccttt atatagttta tggtccttat acagggtatt catgaaaaat gtatccagta
     7621 catcctgttc ttcgaccttt accggataaa tggagtacat caggttggtg ttgtgcatca
     7681 tcagtttgga aggtttcttg ggaaattcct ctcccttggg ataaaccata ttgataagac
     7741 gcgcatctgc cagatactta atgtaattca tcaccgtggc acgtgaagtt tgaatctccg
     7801 tggccagctg gctgacgttc ggagcaacgg gtccgtccac agctagcaaa tatagtaatt
     7861 tttttatctt tgaaagatat ttcagctcaa tttgtttgat aagaagtata tctacttcta
     7921 tcatcatatt catggttttt agcagattct ccgaaaagtt acgtttttcc aggaagaatg
     7981 ggtagaaacc gtgatgcaga tagtcttgaa aataatccaa gggcttcacg ttgcgcagga
     8041 tggttttcgc tatctgttcg tgattctcca aaatttcttg taaggtatag gcacggaaac
     8101 aattgccgct ttgcaaattc agatattcgc ggaatgagaa acctctcaga tagtatacct
     8161 tgacaatgcc gctcagttct ggattttctt ctttcagtcg catcacagat gatccggtga
     8221 atataatctt cagagtagga aacatttcat agcaagcacg caggtcgtgg ctccattcgg
     8281 gatacttaaa cacttggtct atcaacaaaa cttttcctcc tcgttttacg aattctgcgg
     8341 caaactccac taatgtatat ttagagaagt aaaagttatt catgttgatg aacagacatg
     8401 agtgatccgt tccgaacttt tcttttgcat attgcaggag gaaagtcgtt ttccctacgc
     8461 cacgagtacc cttgataccg atcagtctgt cattccagtc tatctcgtcc atcaagtccc
     8521 ggcgaacagg agcatttgta tgttccacca gataactgtg tgttctgtaa aaggtttcca
     8581 tggttgcttt tttatcggct gcaaatatag caatactaat tcaaattgca aactggagat
     8641 agcaaaatat tatttttttt tctactaaaa gacggacaag agaaatggtt tgtactctaa
     8701 aacatttatc tttgtgtccg gaaatggaag cgctttattt attcaatccg gaaaatgata
     8761 tggcattagc ttgtggtgat ccttattata tggcacctgc cagtgcacga cgaatggcgg
     8821 ccgagctatc catgttgcct gcatggtatg cagaagaggg aggaactgtg tggctggatt
     8881 ctgctcagcg tatgaaaaca atggaaagac aatctttttt gccgctttcg gtcaattggg
     8941 ttttagaatt cgtacccatt tataataagg tgattccttg gggatggaat ccgtctttgg
     9001 tgcgtcgttt gcaggaagct ggatttcctg atacagcata tccttcagta gagcgtatga
     9061 agcgtatccg tcaaatatcc ggacgtcaga cggctgtaaa agtgttacgc cgcctttgta
     9121 gacatatagg tgggaatatt cccatattgg gggaggcttt tgtattgtcg tcaatagagg
     9181 aagtgaaggc ttttgtgttg tctcattctc gtgctttgtt aaaagcgcca tggtctggta
     9241 gtggaagagg gatacaatat gtttcaggta gttttcccat ccctctggaa gggtggattc
     9301 gacacatact taccactcag catgaggtga taggagaacc tttttatgat aagcttttgg
     9361 attttgccat ggagtttttt gcagacgagt ggggacaggt acattttata gggtattcct
     9421 tatttgaaac ggataagaga ggtgtttata aagaaaactt gttggcggcg gatcgggtta
     9481 ttgaagcgag gatatccact tatgtttctg cggaaatctt acatcaggtt gggagggcgt
     9541 tacaggtaga gttggcagag gtgataaaag ggagttacga aggctatctg ggggtggata
     9601 tgatggtatg ccgtacccaa aatagcgggt atgccattca tccgtgtgtg gaaataaatc
     9661 ttcgtatgaa tatgggagtg gtagcacgct tgatatatga taactatgtg tgtgatggcg
     9721 tgcagggacg atatgttata gaatattatg caaagcctgg tgaggcatgg cattctcatc
     9781 ttgcgcttca agaaaagtat cctttatatc tggagaatgg aaaagtgaag tcgggttatt
     9841 tgtcacttac accggtagag aacaatacgt cctatcaggc atatatctta atttgatttt
     9901 ccggataaag gaagatacag aaaagagggg atggttacca tccaccccct aatgctttat
     9961 acaattttac taatgtaatc tgtttgtctc ttattgcatt gcttaatcct atttgtgcgt
    10021 cgaaatagct acgttgtgca tccaatacat ctagatagcc tattactcca ttgatgtatt
    10081 gcaattgggc cagttccatt gttgctttag aggaacgttc cagttgcagg cgcgattcgt
    10141 agatatcttt tatcttattg aagtccacaa tggcattgcg ggcctctttg aatgcagtca
    10201 gtactgattt ttcatagctg tagcattcct gttcgtatgc ggcttttttg gcctttaggg
    10261 ttgctctgta ttttcccatg gcgaagagag gagttagaag attgccactg atataatgaa
    10321 tgggcgattt gaagaaatca gagaattctt cactttctac gccatattgt gctgtgaggc
    10381 taagtcgtgg gaacatattg gtataggcaa tacctacact ggcattggct gctattaatt
    10441 tctgttctgc ttcacgtaca tcgggacgac gttccagcag agtggagggt agacctactg
    10501 gtaatgtttc aggtagtttt acttcttcgg gtagaatgga acgctgtatg cggtgcgggt
    10561 attcgcctgc taaaaatgca atatcatttt ctttcaatga aattttcctt tctagttcag
    10621 gaactaaagt tgcggtacgt gcatactcca cttgtgcctg ttgataagaa gtttctgaag
    10681 ttagtcctcc ttcaaaacga agttttgcca agcgtactcc ttctttacgg gcatagagtg
    10741 tttgacgaac aatgttcagc tcattgtcta atgcgaccaa ttcaaaatag gcttgtgcca
    10801 cttcggacac aatactcatt ttcaaggcac gttgcgcctc gatgcttccc aggaattgtg
    10861 ctatgctttt gtcttttgcc caacgcaggt taccccatag gtctaattcc caagttacgg
    10921 taagtttacc acccagttcg gggtcatttt tatagttgtt accaccataa ttacttcctt
    10981 ctttttgagc ataagcgcct ccgttcagtt gggggaaaag gttggcaaag tctatgcgct
    11041 tcattgcggc aagttctttt acacgtgccg cagcaatttt catgtctttg ttgttatcca
    11101 acgttttttc tatcaagctt tgcaaggttg tgtccgtata gatttcccac cactgcatat
    11161 cggcaataga taatgtatcc tgttgtcgta acgtatctaa ttgttggggc agatgcaagt
    11221 cgggacgtgt gtagtgctta cctaattggc aagaagtcag caaagtcatt cctgatacgg
    11281 ctatatataa taatgtatgt ttcatcattt ctttcgtctt tttatatcct tatttttgtt
    11341 tcattttcgc tttcatcttg tatatcagta caaagaagaa aggtactaac aaaattccca
    11401 cagttacagc aaagatcatt ccgaagaata cacctgtacc aatagcttga cggctggctg
    11461 aacctggccc gctggcgata accataggta acatacctaa gatgaatgcc aatgaagtca
    11521 tcaaaatagg tcgaaagcgg agttgtgaag catggagtgc agcttgtacc acatctattc
    11581 ctctgtccac ttgttctttg gcaaactcta caataagaat tgcatttttg gcggccagtc
    11641 ctaccaacat caccaatccg atctggaaat agacatcatt ctccaatcca cagccccata
    11701 cacctagata ggcacctaat gcggctacag gtaaagagag taatactgca accggtacca
    11761 tccagctttc gtataaggca gcaaggaaca aaaacacgaa catgaacact aatgccagca
    11821 ccataccggt ctgtccacct gcttgttttt cctggaaaga tagtccgctc cattctacac
    11881 cgatattttc tggtaggtgt tcgcgagcta tttgttcgat aatttccatg gcctgtcctg
    11941 aactgtaacc atctgcggcc tcaccgcgaa tcacagaact gttgaacata ttaaaacgtt
    12001 tgatgctgcc cggacctgtg gtatacgaag tggtacccaa cgaggtgagc ggtatcatgg
    12061 cattgtctgt accccgtaca aaaaataggt tgatattctc cttatgttcc cggtagggtg
    12121 cttctgcttg aatatataca cggtagatac gattaaacat attgaaatcg tttacatata
    12181 ccgaacctgt ataagctttc atggtcgaga atacatctgc taaaggtact cctgcgaatt
    12241 ttactttgtc acggtctaca tcgaaataaa gttgggggat gtccgcttgt aaagccgagg
    12301 ataaacctga taattcctta cgttttgatg cataatacat caatgtatcc gtagcttgta
    12361 ccaaattttc aaaagtggca tctccacgtg cttccagttg catctcgaaa ccacccgaac
    12421 tgcccaatcc cggaataacg ggaggggtgg aaagatatac cttgcattcg gggtattgcg
    12481 acatgtcttt ttttacctgt gccataatat cgtcaatagt ttgcgagtca cgttcctccc
    12541 aaggttttaa gatgatagtc agttcacttc gtgcctgact ggtccctaca cgcggactgc
    12601 ttcctgccac gctttgtaca tattccactg ccggattttc catcaggtat tccacagcac
    12661 gttccgtcac gatacgtgta cgttccaacg ttgcaccttc gggcagttcc aactctattt
    12721 taaaatatcc ttggtcttcg atggggagga agctggtggg aataatgcga tggattaaca
    12781 ggatggcgat caataccatg ccgaatgtgc tcagtacccg acgcgggtgt ttcacaatgt
    12841 gcttgatgag tcctacatat ttatgattgc cgatagccag ccacttattg atacggcgga
    12901 atatgatatt ctttttcttg ttcggatctt ccggtttcag aataagtgaa cacatgactg
    12961 gactcagtgt caaagctact accgtagaca gtaatacaga tactacgatg gttaccgtaa
    13021 actggcgata aagttgtccg gtaattccac ctagaaaact tacgggaaca aatactgctg
    13081 ccagtaccaa agaagtggcg ataatggctc ctgtaagtcc ttccatagct ttcttggtag
    13141 cttggtaggg agatagtttc tcctcttcca tgatacgctc cacattctct actaccacga
    13201 tagcatcgtc caccacaata ccgatggcaa gtaccaatcc caacagggtc aggatattaa
    13261 gcgagaatcc gaaaatcaac ataaatccaa aagttccaat cagtgagata ggtacggcaa
    13321 ctagtgggat aactgttgca cgccagcttt ggagtgaaag gtatactacg atgataacca
    13381 gtatcagggc ttcaaacagt gttttgtaca cttcatgaat ggattccgaa atatacgtag
    13441 tcatatcgaa aggtatctcg taactcattc cttcgggaaa attcttgctg atttcctcca
    13501 tagcttcttt cacgcttttt gctacttcca tagcgttggc tcctggtaac atatagatgg
    13561 ccaataccgc tgcattttct ttgttgatgg cactctcggt attgtatgat tgtgcttcga
    13621 gtgagatgcg ggccacatca cgtaaacgga tgatggaacc atcggcatta gcacggacta
    13681 cgatttcctc aaactggctt acggtagata gacgtccctg agtagtgatg ggaatggtta
    13741 cgtctaatcc ttgtacgggt tgttgtccca gtacaccggc tgctgattct cgattttggt
    13801 cttttagtgc attctgcaag tcggctacag tcagaccgaa attggccagt ttgtcgggtt
    13861 gtacccagat ttgcatggca taatatcggc ttccgatgtt tgaaacacgt cctacgccag
    13921 ggatacggcg gattaggtcc agcacattca gagtggcaaa gttgctaagg tatatttcat
    13981 cgaacttcgg gtcggtagag gtaaggcata gggtcagcaa ttgactggca gcctgtttct
    14041 ctaccgaaat accattttgt ataacttctg ctgggaggcg tgattctgct aacttgatac
    14101 ggttctgtat ttccactgcc gctagatcgg gatctgccga gatatcaaaa gtgacggtgg
    14161 ctgaaaaacc tcccgaattg gaactatttg attccatgta aagcattcct ggggtaccgt
    14221 tcaattcctg ctctatagga gtggctacag cctgtgatac tgtcagggca ctggcacccg
    14281 gataggatgc gctgattttc actaccggcg gagtaatctg cggatattgg tcaatgggta
    14341 gcatcgtgag accgatgata ccgacaatga ctattaatat ggagatgaca gctgaaaata
    14401 ccggtctgtc tataaagaaa ctaactttca taatgtctat tgtttttttg aatgcgtaaa
    14461 ttttcctcca taggggaatt cgtattcggg agtgaaatta tccgatcgta tcttcttcct
    14521 ccgttttttt gtcctctacg gcaggactta ctttcacttt catgcctgga ttcagcttgt
    14581 ggtatccttc tatgacaatg tcttctccgg gggccaagcc tctttccacc actacttgat
    14641 tttggaattc aggacctaat tcaatgaaac gtctctctac tgtagaatct ttgcgcatta
    14701 cataaatata ggcgccgcct ttttctatga taacggactt taacgggact accgtagcac
    14761 tctctctgac atccaataat agttttactt tggtgaactg cccaggaagt aatacccgtt
    14821 ctggattcgg catttcggca cgtacggaga atgtacctgt gcgtggatca acttgcggtt
    14881 cggcaaagtc tactagtcct ttgtatggat aaatagtatt atctgccaaa gtaatggata
    14941 cattgggttg ccaggagcgg gtggagtctt tttgacctaa gttcacatta cgttctttac
    15001 ttttcagata gtctagagca gtcatgctga aatccactaa tacagtatca ctttttacta
    15061 tggtagcaag caatgatttg ccacccggac cgactaatgt tcctaaatct acgtgacgtt
    15121 cactgatatg ccctgctaat ggagaacgaa ctatagtata acctagttcc agttctgctt
    15181 gatcaagatc ggcactactc atagctaccg acgcttctgc tgtttcatat gcagcagtag
    15241 cattgtccaa gtccaactgg ctggcagcgt tttgttcata tagcggacgg atacgttcta
    15301 agtcgcgttt tgctttttgt gcttgtgcct catccttttt caattgggcg cgcgctttgt
    15361 cagctttggc ccgatattga tcttgattga taacaaacag cacttgattt ttagtgacat
    15421 atgtaccttc tgcgaaaagc atttgttcta aatatccctc tactcgggca cgtacttcaa
    15481 cgaattgctg tgcacgtacg cgtcctacat attcaccata tatttccaca tcgtcttgcg
    15541 ttgctggtgc tatggcaact actggaagtt ccggcatctt tgccggttga tgggaaacaa
    15601 tcaggtaaat cccgataact agtccaatac ctattactac aagcgctgtt cttttctttt
    15661 ttagcgcaat ttctttgtgt gtaaaaaata gtttcatact ttagttttgt tattgtttaa
    15721 gatgccatca gtagaaatac aagcagcgtg ccaaactatt gtaaatagtc tttcctattc
    15781 ataatcagtg ctttatttct gtcttttgtt gatagggaaa gtgtggaaaa taggcaacag
    15841 ctgtagaata attccacagt aggcgtaatt aaatttagta gaggattatc gatttggatg
    15901 caaaaatagt aaaatagtgg gtaatcttaa aatatttatt cactattcat tataatgagg
    15961 aagatgttat agtgttagca gatatgtatg caatttaaat tttgcttgag atcgtcgtat
    16021 ctgcaacctt attgttttga aaacacgccc cctttcattt tgaaaagggt tgtgtttttc
    16081 ttttttatga ctgaatatgg tatctgtttg tttatcagga gattatagtc ttctttttca
    16141 ttttggcata gtattcgcta tatacttgtc aaatataaaa ggtataaaaa gatgggagaa
    16201 ttttataatc cagataaatt atataaaggt ggaagccgaa ataatagctt gataaataaa
    16261 aaaatgatat tccgtgtatt gggagtatta ctttttattg aatctgctat gtttctgctt
    16321 tgtgcggcta tttccttatg ttacggcgag caagattatc aatattttct atataccatt
    16381 cttttgaata cattggtcgg tggagttttg ctaatttgta gtagaggtgc tgagaatcga
    16441 ctaacacgac gagatgggta ctgtattgta acttttactt ggtttttgtt tacgttgttt
    16501 ggaatgctac ctttttattt tagtggagga atcccttcag tgacagatgc tttttttgaa
    16561 accatgtcgg gttttactac tacaggagct actatattag atgatataga atctctttca
    16621 catggcctgt tattttggcg tagcctgaca caatggatag gtggcttggg tattgttttt
    16681 tttactattg ctgtgcttcc tattttcggg ggaggaacta tacaactttt ttcagctgag
    16741 gctatcggag tgacgcacga caaaacacat cctcggattg atgtgatggc taagtggctg
    16801 tggatgatat atgctatcct tacagttgta gaaactatgc tgctgatgat aggaggaatg
    16861 agtttttttg acgcggtatg tcattcattc tctacaacgg ctacaggtgg ttattctact
    16921 aaacaagcca gtgtggctta ttggaattct ccgtttatag aatatgtaat agcgatattt
    16981 atgattcttt cgggtattaa tttctctctc tattttatgt gcctgaaagg gaagggcaag
    17041 cgtctatttc aggatgatga attccgttgg tttatgaaat cagtaagtat tctgacgctt
    17101 gttatcacgc ttgccttagt ttttcagaat cattatgatt gggaaaaggc attccgcagg
    17161 gctctgttcc aagtggctac ggcacatacg tcatgcggtt ttgcaacgga tgattataac
    17221 ttgtggccat cttttacatg gatgcttctt atttttgcta tgttgtcggg tggatgtacg
    17281 gggtctacta gtgggggaat caaaaacatg cgccttatga ttctggcgcg taatatcaag
    17341 aatgaattca aacggatgct
//
